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An alert child repeatedly changes the direction of gaze to fixate on different targets , whereas the child with impaired vision appears to look past the examiner with inaccurate and less frequent eye movements . They also found that HGPS is associated with significant changes in the shape of the nucleus ; these structural defects worsen as HGPS cells age in culture . Associated with the Safer Communities movement was a significant change to traditional policing , and the development of a police community involvement program . SWC analyzes ongoing and emerging issues and trends relevant to gender equality benefits for policy makers in both government and the private sector and promotes concrete changes in policies and programs affecting women . It also offers recommendations that are more in the nature of suggested directions than concrete changes . Analysis of the correlated motions in the enzyme , cofactor , and substrate reveals significant changes in the correlations during the reaction and identifies the correlated motions most relevant to hydride transfer . The words have changed . There are also lots of reasons for them to be pessimistic in view of a changing work environment , a tough and competitive worldwide technology skills market , and a hard-nosed business environment where you often are expected to hit home runs your first time at bat . Their study of 239 patients concluded that their patients had significant clinical improvement in symptoms , which correlates with objective changes in voiding during a 12-month follow-up study . Batterings ' , conditions at the prison had changed little . He had discovered one day that by opening every door in his place ( always excepting the outer one , which he only opened unwillingly ) and by placing himself on this particular spot , he could actually see to a greater or less extent into each of his five rooms without changing his position . The look and feel of Lucid Chat can also be changed from this administrative module . The joyful look with which she recognised him changed almost in the same moment ; his face wore an expression that alarmed her ; it was stern , hard-set in trouble , and his smile could not disguise the truth . Most notable is the changing structure of the broiler ( young chickens raised for slaughter ) , pork , and beef sectors . Changes and additions to it were made as funds became available . This is especially true when dealing with rapidly changing investment markets , where information must not only be kept confidential , but must also be accurate and timely . When WebMaster released the second version of ConferenceRoom , it marked a significant change in the underlying architecture of the server .