[lemma=of] □ □
[lemma=of] □ □ □
[lemma=of] [□] □
All numbering requests ( such as designation of routes , changes in existing numbered routes , or deletion of routes ) were submitted by the State highway agencies to AASHO and its successor , the American Association of State Highway and Transportation Officials , for review and action . Oxidative stress may contribute to COPD through many biological actions , including cellular injury , oxidation and nitration of proteins , changes in gene expression , stimulation of mucous secretion , inactivation of antiproteases , expression of proinflammatory mediators , remodeling of blood vessels , and enhancement of apoptosis ( 22 ) . Agency 's inclusion of new respirator requirements in the comprehensive substance-specific standards promulgated under section ( 6 ) ( b ) of the OSH Act , e.g ., fit testing protocols , respirator selection tables with assigned protection factors , use of PAPRs , changing filter elements whenever an employee detected an increase in breathing resistance , and referring employees with breathing difficulties , either at fit testing or during routine respirator use , to a physician trained in pulmonary medicine ( see , e.g ., 29 CFR 1910.1025 ( OSHA 's Lead Standard ) ) . Any increase in the number or severity of cases , change in the type of diarrhea , rise in diarrhea-specific mortality , or change in the demographic breakdown of the cases should be reported . A process is defined as A series of actions , changes or functions that bring about an end or result .