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The drug was < 4 % bound to plasma proteins , indicating that drug interactions involving binding-site displacement are unlikely ( see Drug Interactions ) . Uncommon adverse events ( < 4 % ) reported in clinical studies included chest pain , syncope , hypotension , impotence , alterations in taste or hearing , confusion , seizures , memory loss , disturbances of libido , bruising and coagulopathy . We discuss the basic issues and possible strategies in order to achieve < 4 % color errors over the wavelength range of 350 nm to 1.7 microns . However , advances in surgical , anesthetic , and critical care techniques have dramatically lowered this figure , and experienced centers now report mortality rates of < 4 % .16 This is no different from the mortality rate for a standard pneumonectomy . United States ( < 4 % vs. 5.9 % ) . The prevalence of serious disease among pups ( resulting in death , euthanasia , return , or extensive treatment ) was < 4 % for all sources and did not differ significantly between pet stores and other sources . After 3 months of treatment ( one complete sperm cycle ) , the difference between placebo - and pregabalin-treated subjects in mean percent sperm with normal motility was < 4 % and neither group had a mean change from baseline of more than 2 % . It is apparent that liquid limits for Keewatin “ muds ” are very low with respect to other arctic or subarctic “ muds ” and that plasticity indices are low ( < 4 % ) or unmeasurable . Metabolism : In humans , the N-oxide is the principal metabolite in the urine ; however , this amounts to < 4 % of the dose . Calculations , based on the amount of carbohydrate and protein removed by these chemical treatments , suggest that the energetic demand for synthesis of the non-protein fraction of EPS by this organism represents only a small fraction ( < 4 % ) of the anabolic ATP expenditure of the culture . Born-Frechet kernel theory is valid for small-scale heterogeneities but restricted to weak perturbations ( < 4 % ) .