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They have been shown in various tissues to modulate signaling and gene activation in response to short-lived endocannabinoid ligands or THC . This contrasts sharply with the report by D'Cruz et al. [ 3 ] of mutations affecting mostly K-Ras and also N-Ras , but never H-Ras , in mouse mammary tumors induced by an MMTV-c-Myc transgene . Coloured lines indicate corresponding regions of the shell and periostracum in ( a ) and ( b ) . Human embryonic stem cells ( hESC ) offer a renewable source of a wide range of cell types for use in research and cell-based therapies to treat disease . If interested to a single gene , the more exhaustive solution to this problem would be to generate and evaluate a list of candidate partners for every possible pairwise combination of ESTs probes .