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Detection and elimination of pathogens is a consequence of millions of small cells - detectors - interacting through simple , very localised rules , to give rise to a truly efficient distributed system . If an agreement is not reached , the employee and / or the union representative may appeal to the Board for further consideration of the matter . There are millions of lymphocytes , so what we have is a system of highly distributed detection , where there is no centralised control , and little , if any , heirarchical control . These projects are probably more difficult to resolve in a single semester than are empirical projects , so a thorough analysis and formulation of the problem would suffice for a semester project . Each PRINCIPAL will annually include information about the complaint procedure along with the Nondiscrimination Policy statement in the first issue of the school newsletter and in the pupil and staff handbooks , course selection handbooks and other published materials distributed to the public describing school activities and opportunities . Affinity maturation takes place in the lymph nodes , of which there are many distributed throughout the body . And then when the pain would subside , she would be up on her feet , and the people around her would not have the slightest idea about what happened , because she never sought sympathy , she never complained , she kept smiling and she gave us everything that we wanted . Helper T-cells provide distributed censoring of B-cells through a mechanism known as costimulation .