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The disadvantages and shortcomings of drugs in offensive operations become positive features of the defensive posture . The disadvantaged party may not have the resources to obtain good forensic DNA information , or the knowledge to use it . The disadvantages include the high cost of production in vivo , the slow rate of action , the lack of effect on adult Japanese beetles , which also cause obvious and distressing damage , and the need for large areas to be treated for effect ( see below ) . The disadvantage of this approach is that a new MRM would have to be distinguished at the API level ( and hence have to be explicitly selected by signalling applications at the API ) , which leads to several of the same problems as in the off-path NTLP case . The disadvantaged are the rural poor who live in marginal and fragile areas typically characterized by low rainfall , rough terrain , high altitudes , poor soils and poor access to roads , markets and services . The disadvantage is that your benefit is permanently reduced . The disadvantage is that it can only be used on windows 95 platforms . The disadvantages of this approach are that the destination must have an up to date version of Ant correctly pre-installed , and Ant does n't allow you to handle failures well - and a good installer is all about handling when things go wrong , from files being in use to jar versions being different . The disadvantage of visiting too many parks is that one would be spending a lot of time packing and unpacking as well as traveling among destinations , thus cutting into the time for wildlife photography and viewing . The disadvantage is that the user must `` sketch '' each proof by listing the rules involved . The disadvantages include the special expertise required to perform the procedure , time and expense .