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In addition , the presence of many tumor cells with myoepithelial features ( for example , expression of smooth muscle actin ) and other observations suggest that in the Wnt pathway oncogenes transform cells positioned early in the developmental program for mammary tissue , whereas oncogenes like ErbB2 / Neu that activate Ras proteins , either transform cells that are more advanced developmentally or drive cells to a more mature epithelial character during oncogenesis . Tissue height of stria vascularis was normal ( Fig. 5 ) , consistent with the similar numbers of 18S rRNA molecules in isolated preparations ( see above ) . The most highly conserved region in the whole alignment is centered on a Cys residue in the motif Cys-Xaa-Gly ( bold type indicates residues found in the catalytic triad of sortases ) . Two very large , naturalistic , prospective , 3-year studies have been recently completed , reporting findings consistent with US-SCAP . This line shows three distinct alleles at passage 29 , consistent with trisomy 13 as shown in the karyotype [ 17 ] . ( F ) Collagen fibrils possessing a rod-like structure with the characteristic ~ 67 nm banding pattern validating the presence of fibrillar collagen in proximity to epithelial cells . Most importantly , the current findings are highly consistent with RCTs [ 14,42 ] and 3 large naturalistic studies conducted outside of the U.S. that included only monotherapy-treated patients [ 30-32 ,40 ] . Previous research has established the absence of target medication for more than 14 days as a valid indicator of drug discontinuation [ 4,21 ] . As many examined cases were not able to give valid information , the primary care taker and other family members were also interviewed . Therefore we suppose that retrospective assessment of khat intake is more valid than that of food intake . The absence of a change in tissue height is consistent with the presence of intermediate cells [ 28 ] .