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Hence , defense expenditure must be qualified by a measure of cost effectiveness . The disorder may be caused by a deficiency of one or more of the enzymes methylmalonyl CoA mutase , methylmalonyl racemase , or adenosylcobalamin synthetic enzymes . Type I diabetes is marked by a deficiency of endocrine beta-cells in the pancreatic islets of Langerhans . These disorders are caused by a deficiency of an enzyme essential to the process of breaking down the complex molecule . The other way that we can err is by a deficiency of indulgence-suppressing what we should put up with . A joint criminal enterprise is an understanding or arrangement amounting to an agreement between two or more persons that they will commit a crime.7 Joint criminal enterprise constitutes an extended form of individual criminal responsibility that covers " actions perpetrated by a collectivity of persons in furtherance of a common criminal design . For now , it sits in storage , its burnished white-and-gold console protected by a sheet of plastic . My teaching partner and I discovered by accident this Sept that the kids were less intimidated by a sheet of paper than the bound journals . In the wilderness of sorrow he was sustained by a vista of the promised land . In both cases , the matching lines are sorted by a measure of how famous they are , so most of the time you will find the most " useful " result right at the top . It is characterized by a deficiency of the enzyme isovaleryl CoA dehydrogenase .