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Thus , although mtDNA mutations are quite common in somatic cells , the functional consequences may be greater in stem cells . She is horrified , the only character responding sympathetically to the execution . In Braque 's l'Estaque landscapes of the previous year , the two-dimensional surface of the picture is retained partly by allowing the eye no way of escape beyond the mountains , buildings and trees , and here the same effect is achieved by the concrete treatment of the sky , which is as elaborately and solidly painted as the rest of the canvas , and which is fused with the landscape below by the extension into it of all the main compositional lines ... Alternatively , we have also provided data on embryonal carcinoma and karyotypically abnormal hESC lines , which are potential reference materials . However , the small perspectival wedge on the right is so surrounded by the ample thigh , the fall of the coattail ( which almost but not quite comes into contact with the chair ) , and the triangle of wall seen beyond the chair that its spatial implications are quite different from those of the more simply constructed section to the left - - although this area , too , is made more complicated by the inexplicable white form that appears under the sitter 's projecting hip , where the wooden rail must be attached to the caning . In contrast , the karyotypically normal subline SA02.5 , which was subcloned from SA02 , carries only two alleles on chromosome 13 . However , the third most common was PT 14b , a phage type hitherto uncommon in Sweden with only 20 to 40 cases reported annually prior to 2001 . Each late passage line or karyotypically abnormal subline ( BG01V , SA02 ) is identical to the early passage line , showing no evidence of overgrowth by contaminating cells . In the first place , in a style in which one of the fundamental problems had always been the reconciliation of solid form with the picture plane , the letters written or stenciled across the surface are the most conclusive way of emphasizing its two-dimensional character ; Braque has stressed this when he said of the letters : ' they were forms which could not be distorted because , being quite flat , the letters existed outside space and their presence in the painting , by contrast , enabled one to distinguish between objects situated in space and those outside it . Although the proposed method is tested on a SRBCT data set , it is quite general and can be applied to other cancer data sets .