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[!tag=NNP] [□] □ □
[!tag=NNP] □* □ □
Numerous types of chromosomal abnormalities have been observed , involving [ 1p , 1q , 2q , 3p , 4p , 5q , i ( 5p ) , +7 , +8 , 8p , 9p , 9q , 10q23-25 , 11p , 11q , +11 , 13q , 14q , 17p , 18q , 21q , and Y ] . On September 20 , 1961 , President John F. Kennedy wrote the Archivist of the United States to ask him to consult with White House staff and representatives of Harvard University concerning establishment of a Presidential library in Cambridge , Massachusetts . On September 6 , 1955 , however , it was desecrated and destroyed again by the Moslem Turks ; it has been restored again , but not to the former magnificence . Christopher Columbus landed on the island of Cuba on October 28 , 1492 , during his initial westward voyage . On June 16 , 1998 , Pyongyang publicly offered to negotiate an end to its development as well as export of ballistic missiles .