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The study measures a range of student health indicators , from dietary intake and physical activity to bone mass and heart disease . We are applying three-dimensional , nonlinear , finite-element codes that assign material properties to bone and the soft-tissue structures associated with joints . It also indirectly accelerates osteoclastic activity , increases urinary calcium excretion , and contributes to bone loss . Thus , TNF increases the total number of osteoclasts at any given time , which leads to bone destruction . In fact there has never been any proof that an HIV kills these cells , or indeed that even when they seem in low numbers in a person 's blood , cells have not instead migrated out of the blood to bone marrow and elsewhere .