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We do not have yet sufficient data to conclude whether maximal androgen blockade from the combined use of an LH-RH agonist and an antiandrogen will prolong the survival in patients with metastatic prostate cancer , nor to conclude whether neoadjuvant androgen ablation therapy improves the disease-free survival of patients after radical prostatectomy . If excess androgens are the primary cause of the hirsutism , androgen receptors are found in the anagen ( active ) phase in the follicles ' dermal papillae and associated sebaceous glands , where stimulation is provided by the more potent androgens testosterone and dihydrotestosterone . " It 's not as abrupt a situation as women with menopause , but there has been a similar term , " andropause " or androgen deficiency in the aging male ( ADAM ) or male menopause , that is linked to a constellation of symptoms in older men that are all very vague , " Nelson said . Results : We show that androgens , such as T and plasma membrane-impermeable bovine serum albumin-conjugated T ( BT ) , cause a rapid ( minutes ) increase in the accumulation of cyclic adenosine 3 ’ ,5 ’ - monophosphate ( cAMP ) and subsequent activation of protein kinase A ( PKA ) in androgen-sensitive LNCaP cells .