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They began with the framework of perspective lines , and they built up the human body through their knowledge of anatomy and of the laws of foreshortening . And in the early 1490 's he received from the same patron who had ordered The Birth of Venus , Lorenzo di Pierfrancesco de ' Medici , a commission of a very different kind , an immense series of illustrations to Dante . ( d ) A schematic representation of the distal region of the mantle tissue where biomineralization takes place , corresponding to the red box in ( c ) . The mantle ( Mt ) continuously secretes these structures . ( d ) Dissected portion of the mantle ( corresponding to the boxed region in c ) . In using this approach to study Homer , I am indebted to the work of Erik Erikson and his followers on identity and the life cycle . ( W and w ) HasSom expressed discontinuously within the anterior zone of the outer fold the mantle . The fold changes are shown on the log2 scale , so the dashed line at zero corresponds to no differential expression , positive values correspond to up-regulation in treated cells , and negative values correspond to down-regulation in treated cells compared with untreated control cells ( see additional file 1 on fold change calculation and gene matching ) . The book is , too , frankly a late middle age project , in which I look at the life and pictures of a person approximately one hundred years my senior whose life also took one unexpected turn after another . ( c ) The mantle tissue that covers the majority of the dorsal surface of the animal is shaded grey .