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There is always a risk that the system properties being analyzed are not the ones that will ultimately dominate the system 's characteristics . There is always the risk that a virus has got past both the anti-virus software and Sophos . However , there is always the risk that the questionnaires might not have measured all the predisposing variables . It has not yet become riddled with political issues , and although I don ’ t believe this will be a problem in the future , there is always the risk that political fall-outs can occur in a project such as this . There is always the risk that the effect on the surrogate , despite its reasonableness , will not reflect an ultimate clinical benefit , but in these urgent cases , that risk appears acceptable . There is , of course , always a risk that the possibilities of emerging media will help to create a culture of " true belief " .