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In addition , industry has committed to developing a system to more closely evaluate the benefit in patients with LVEF 30-35 % , NYHA Class IV in CRT-D , or NIDCM of 3-9 months duration . ( This issue was illustrated by the impressive performance of ritonavir-boosted TMC-114 in enfuvirtide-naive patients receiving enfuvirtide.41 ) New thinking about how to design trials combining 2 new agents is needed as quickly as possible ; doing so will maximize the benefit for patients with limited treatment options . If voluntary contributions are used to purchase annuities to provide part of the benefit at retirement , the part of the total benefit provided by voluntary contributions is not subject to the IRC 415 ( b ) ( 1 ) limitation . Cilostazol has shown some benefit in open-label trials , and a recent double-blinded randomized trial showed that it significantly increased the mean brachial artery diameter ; however , the patient 's subjective symptoms did not appear to improve ( Rajagopalan , 2003 ; Dean , 2001 ) . " In order to bear down and focus on their own personal responsibilities , people may need a longer conversation , and they may need assurances that they can expect some benefit in return for taking more responsibility . In order to increase the benefit for both parties , the University agrees to offer other appropriate employment to faculty members whose programs are discontinued , and the faculty members agree to be flexible in accepting alternative assignments . The benefit for them is that they get a first look at our top tier of candidates before we send them out to their competitors . And , most of all , it results in a school where the collaboration involving families is real and the benefit for each student is evident .