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This prompted , first , surgical intervention [ Kitterman 1972 ] and , later , pharmacological treatment using indomethacin [ Heymann 1976 ] in an attempt to improve the outcome in these infants . Individuals with research interests related to the structural and pharmacological aspects of cell signaling are particularly encouraged to apply . I think it was due to the taste , though , rather than anything pharmacological . This information , appropriate for patient care situations , includes : common , as well as colloquial names , brand names , scientific names , product uses , safety , effectiveness , description of known constituents , pharmacological actions , adverse reactions , possible interactions , any influence on nutrient levels and depletion in the body after use of the substance ( s ) , dosage and administration , and reference citations . The program provides broad-based training in modern research concepts regarding the pathophysiology of these and other neurodegenerative disorders and potential disease-modifying molecular targets that can drive the discovery of pharmacological and gene therapeutic strategies by which the devastating effects of these disorders can be ameliorated .