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Secondly , we found no clear trend with ibuprofen duration – albeit that could , in part , be explained by some misclassification of exposure due to over the counter use of ibuprofen . The RNA polymerase protein sequence is shaded in red and the intein sequence in blue . Panels ( a ) and ( b ) show the full study and validation cohorts , respectively , as described in the paper ; the treated and untreated sub-cohorts of the validation cohort refer to adjuvant hormonal therapy , as all patients received surgery and radiotherapy . The fold changes are shown on the log2 scale , so the dashed line at zero corresponds to no differential expression , positive values correspond to up-regulation in treated cells , and negative values correspond to down-regulation in treated cells compared with untreated control cells ( see additional file 1 on fold change calculation and gene matching ) . Wounds in our system are smaller and more physiological , rarely larger than 200 μ m , so there is therefore no immediate contradiction between our work and this new study ; however , the situation appears to be more complicated than that presented by either paper , and there is clearly more work needed . For this reason , we counted only those persons as positive screening cases when their existence in the household could be validated ( e.g . Initiation was defined as the start of an antipsychotic that was not prescribed during the previous 60 days or more . In fact , we find four examples of fusion proteins with both EpsH-like and CAAX prenyl protease-like domains . When comparing each of the atypicals to the typicals ( combined ) , and to typicals of high - , medium - , or low-potency level ( separately ) , only clozapine , olanzapine , and to a lesser extent risperidone were consistently associated with significantly longer time to medication discontinuation ( p < .05 ; Table 3 ) . To that end , we performed an additional sensitivity analysis in which the time from patient 's enrollment in US-SCAP to the time of patient 's initiation on the index medication was used as a covariate in the Cox Proportional Hazards regression model . When excluding clozapine , which was not included in Phase 1 of CATIE , both studies found olanzapine-treated patients to have the longest time to medication discontinuation , followed in descending order by risperidone , quetiapine , and ziprasidone . Larger wounds in Pax6 + / - corneal epithelia healed faster than smaller wounds ( presumably because larger wounds were closer to the source of proliferating limbal stem cells ) , and extrapolation from figure 2 in that study [ 59 ] suggested that wounds smaller than 500 μ m in diameter would heal more slowly than wild-type . In summary , after finding representative EST clones for the gene of interest in cDNA microarray datasets of both species , we order all the ESTs in each dataset according to similarity of their expression pattern with that of the chosen ESTs . THC binds to and activates either one of the two cannabinoid receptors ( CB1 and CB2 ) located on the surface of both brain and lymphoid cells [ 17-26 ] . To further assess the robustness of the findings , sensitivity analyses were performed , including the use of ( a ) only 1 medication episode for each patient , the one with which the patient was treated first , and ( b ) all medication episodes , including those simultaneously initiated on more than 1 antipsychotic . For all lobes of the cerebral cortex , and for the cerebellum , supplementation with 0.3 % ( T + ) or 0.6 % ( P + ) DHA did not support tissue DHA concentrations similar to those of the breastfed group . The trends for ARA are very different from those for DHA . The prevalence of ESTs corresponding to other proteins of the same complexes was then determined for both approaches . In addition , with bitransgenic mice , we could ask whether a co-existing MMTV-Wnt1 transgene eliminated the selective advantage conferred by an activating mutation in the coding domain of the MMTV-Neu transgene , and we could ask whether the phenotype of tumor cells in resulting tumors resembled the phenotype of tumors induced by components of the Wnt pathway , the Neu / Ras pathway , or both . We showed that the two phases can be decoupled but that both are required for healing . The screening interview assessed individual socio-demographic information , khat consumption and experiences in the civil war ( subjects were grouped as either active war participants , civilian war survivors , or without any war experiences ) .