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His argument runs as follows : no matter how creatively you manipulate your mattress , once it 's back on the bed you will have performed one of the four operations I , R , P , Y shown in the figure . Of these material elements - for example - fire , the keen and swift , cooperates by its upward tendency as earth by its lingering below ; for we must not imagine that the fire , once it finds itself at the point where its ascent must stop , settles down as in its appropriate place , no longer seeking , like all the rest , to expand in both directions . The discovery begins to shed light on how the virus , once it has breached the cell membrane , uncoats and converts its genetic material , RNA , into DNA for replication . He was blowing air out his anus , as usual - he knew that this document would be devastating to their case , once it was out . The commoness of the gene , once it was introduced as a mutation , was a balancing act depending on how bad the malaria situation was among a population .