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As the mean age at randomisation was 35.6 weeks PMA and the intervention involved targeting either oxygen saturation range for a minimum of two weeks , it is likely that virtually all enrolled infants would have been oxygen-dependent at 36 weeks PMA , rendering the reporting of this outcome in the included trial meaningless . However , it was noted in the results of the included trial ( Pyati 1983 ) that there were no systemic or local adverse reactions to the penicillin during the study period . Three reviewers assessed the methodological quality of potentially eligible trials and two reviewers independently extracted data from the included trial . In light of improved oxygen administration and monitoring techniques since the included trial was conducted , the question of duration of oxygen therapy has been superseded by the question of what are appropriate target oxygen levels . Once the device has been recognized , you can install the bundled software and any of the included trial version software packages that might interest you .