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Carbon 3 is free of this compound and can be combined with sulfhydryl groups in the tissues , but its use should be carefully restricted to situations under clinical surveillance [ 17 , 23 ] . Although clinical trials are governed by extensive regulations to ensure that they are ethical and as safe as possible , individuals considering clinical trials should carefully weigh the possible risks of participation against the potential benefits . In analogy it is more like Clinical Faculty . The drip is continued for 1-3 days , until clinical or laboratory investigations demonstrate thrombus resolution . In early December , because clinical pertussis had been identified among children , we undertook a school survey to review progress of the outbreak . Furthermore , the clearance of fluvoxamine is decreased by about 50 % in elderly compared to younger patients ( see Pharmacokinetics under CLINICAL PHARMACOLOGY ) , and greater sensitivity of some older individuals also cannot be ruled out . The yield from sporadic cases is likely to be low , because clinical diagnosis is unreliable in this setting . It is important not just from a patient and public safety angle but because clinical practice itself has changed . Fluconazole , 400 mg / d , is considered the drug of choice , and should be continued for 1 to 3 months after the active infection has resolved.9 Ketoconazole , 200 to 400 mg / d , and itraconazole , 400 mg / d daily , have also been used for this infection , although clinical comparisons with fluconazole have not been reported . The number of isolates available for examination will always be less than the number of clinically notified cases because clinical surveillance case definitions include culture negative cases .