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The requirements are to be applied during the design , construction , additions to , and alteration of facilities and elements on passenger vessels to the extent required by regulations issued by Federal agencies under the Americans with Disabilities Act of 1990 ( ADA ) . This site has security measures in place to protect the loss , misuse , and alteration of the information under our control . These later events , which are also observed with ethanol or acetaldehyde exposure , include cytoskeletal disruption ( 48,49 ) , mitochondrial dysfunction ( 50-53 ) , and alteration of membrane protein receptors and subsequent signal transduction ( 31,54 ) . The cardiac manifestations observed in HIV / AIDS include cardiomyopathy ( problems with the heart muscle ) , pericardial effusion ( problems with the fluid surrounding the heart ) , mitral valve prolapse ( heart valve problem ) , bacterial endocarditis ( infection of the heart itself ) , and alterations of contractility ( beating ) of the heart . Upstream of the dams , the increased depth of water , buildup of sediment , decreased levels of dissolved oxygen , and alteration of host fish populations threaten the survival of the mussels .