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Insights into the fundamental degradation and repair processes occurring in the OA joint will be gained when it is possible to decipher the complex interactions between GH , IGF-1 and other cytokines and growth factors in the peripheral circulation and how they interact with each other to cause destruction of cartilage and compromise repair of cartilage in the synovial joint . These ambitious goals will be pursued through the joint coordination of a set of research projects . Once the smokiest of bars , this joint above Burger Tex has built a smoking area outside , and the indoor haze has cleared . The resulting workers state began developing close links with its Yugoslav neighbor , including common price and currency systems and joint economic planning . DOL will still decide whether employers and the contractors who bring workers to their farm are joint employers equally liable for labor law violations on a case by case , but the new rules make it easier for DOL to consider farmers and contractors joint employers .