[tag=NNS] | [tag=□] □
[tag=NNS] | [tag=NN] □
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This pool shows great concordance of expression with individual normal hESC lines , as the correlation coefficients ( r2 ) with normal lines average 0.87 , or 0.93 for genes expressed at high confidence levels . In tumors induced by components of the Wnt signaling pathway , a high proportion of cells produce proteins ( Sca-1 , Keratin 6 ) associated with early stages of mammary development , whereas few such cells are observed in tumors induced by activators of Ras signaling [ 9 ] . Figure 5 presents the probability of discontinuing the medication during the 1 year following initiation for each atypical antipsychotic compared to perphenazine , and Table 5 presents the hazard ratios ( HR ) and 95 % confidence intervals of time to all-cause medication discontinuation of each atypical agent versus perphenazine using the Cox Proportional Hazards regression model . The association of PEP-CTERM system components with exopolysaccharide biosynthesis and transport genes must be considered against the fact that exopolysaccharide is expressed in a much wider group of organisms than PEP-CTERM . These findings were driven primarily by clozapine and olanzapine , as treatment with risperidone did not differ from perphenazine on 2 of the 3 statistical methods , whereas treatment with quetiapine or ziprasidone did not significantly differ from perphenazine on any of the 3 statistical methods . For example , the expression profiles of tumors reflect the transgenic oncogene [ 5 ] ; moreover , those tumors induced by genes that activate the Ras signaling pathway ( for example , polyoma middle T antigen , ErbB2 / Neu , and H-Ras ) are more similar to each other than to tumors induced by components of the Wnt signaling pathway ( Wnt1 , β - catenin , and c-Myc ) with respect both to gene expression patterns ( [ 5 ] , S. Huang et al ., in preparation ) and to cellular composition and histology [ 6-9 ] . Remarkably , not all the 5 studied atypicals differentiated significantly and consistently from typicals of various potency levels , as findings were primarily driven by clozapine and olanzapine , and to a lesser extent by risperidone . Table 5 presents the hazard ratios ( HR ) and 95 % confidence intervals of time to all-cause medication discontinuation of each atypical agent versus all the typicals using the Cox Proportional Hazards regression model . queries and lists of true positives for performing ROC analysis of translated nucleotide search algorithms . PEP-CTERM proteins could not both remain anchored to the inner membrane by the C-terminal transmembrane domain and basic cluster , and be exported like other components of exopolysaccharide . Most importantly , the current findings are highly consistent with RCTs [ 14,42 ] and 3 large naturalistic studies conducted outside of the U.S. that included only monotherapy-treated patients [ 30-32 ,40 ] . Some of these assays have been previously performed on individual lines , but to our knowledge , no single group has used all of these tests on any single line , and few comparisons between lines have been made publicly available . In addition , with bitransgenic mice , we could ask whether a co-existing MMTV-Wnt1 transgene eliminated the selective advantage conferred by an activating mutation in the coding domain of the MMTV-Neu transgene , and we could ask whether the phenotype of tumor cells in resulting tumors resembled the phenotype of tumors induced by components of the Wnt pathway , the Neu / Ras pathway , or both . Other confounds may have also affected the findings . Coloured lines indicate corresponding regions of the shell and periostracum in ( a ) and ( b ) . It should be noted , however , that the current findings are consistent with CATIE [ 14 ] , in which the ziprasidone-treated patients had the shortest median time to all-cause discontinuation ( 3.5 months in the 18-month trial ) among the 5 treatment comparators , and the highest rate of discontinuation rate for any cause ( 79 % ) . In global gene-expression studies , such as the data presented here , NTERA-2 closely mimics hESC lines , showing an average r2 with the hESC pool of 0.84 for all genes and 0.88 for genes at high confidence . This has been reported in a range of cell systems , mainly in cell lines [ 23-29 ] . Recently , algorithms have been developed that allow oligonucleotide SNP arrays to measure chromosomal copy number at high resolution [ 19,20 ] . Table 5 presents the hazard ratios and 95 % confidence intervals for time to medication discontinuation of each atypical agent versus haloperidol with prophylactic anticholinergic agents , using the Cox Proportional Hazards regression model .