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In the hours subsequent to this , cell proliferation is initiated ; this last process is also modulated by Pax6 and the role of Pax6 in this regard has been studied previously [ 64 ] . The percentage of compatible predictions was determined as in the previous table using the functional index described in the text . Secondary events also appear to be required for mammary tumorigenesis in MMTV-Neu transgenic mice because the transgene in the tumors usually contains an acquired mutation that activates the Neu protein-tyrosine kinase . ERK1 / 2 activation was shown to be required for rapid initiation of wound healing , but had only a minor effect on the rate of cell migration in a healing epithelial sheet . Extracellular calcium was required for the large initial calcium rise , and intracellular calcium stores were shown to be essential for wave propagation . Our data strongly support a model whereby the injury-elicited calcium wave is required for wound healing [ 60 ] , and indicate that the subnormal propagation of the calcium wave in Pax6 + / - corneal epithelia underlies the wound-healing delay . Further propagation of calcium rise to cells away from the wound is required for the wound response , which is realized by cell-cell signaling via P2Y receptors and involves predominantly calcium from intracellular stores . But this religious temper was complicated by an almost morbid hunger for physical beauty . As described above , in the whole-eye culture system , the corneal epithelial migration is modulated by the presence of an inflamed stroma , which would be expected to accelerate cell migration over extended periods of healing . During Homer 's formative and practicing years to observe meant to report attentively on common interests , to point to conclusions that could be ratified by others .