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Even in premarketing clinical trials of protease inhibitor combinations , which included the most carefully screened , dedicated , educated and conscientious participants who were closely followed in generously staffed settings , between 15 % and 35 % did not achieve or maintain viral loads below the standard threshold for quantification ( 400 copies / ml ) . The local Information System Security Officers ( ISSOs ) or their designee must sign a certification that the equipment has been properly sanitized before it can be surplused , transferred , or donated . Opposition to carve-outs is based on the view that with a comprehensive health care system , the primary care physician is pivotal in the diagnosis of drug abuse and can prescribe unified , coordinated health care . Thus , for people who have been brutalized , terrorized , exploited , manipulated , dehumanized , marginalized , intimidate , and repressed for so long , their empowerment is a signal for liberation ; an opportunity to take charge , and a once and for all opportunity to reorganize how they govern themselves and live their lives . A more general , but flexible app gen such as a language generator requires a greater investment to create telecom languages , but pays off down the road when visual applications are easily created , modified , and maintained .