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It may well be that the destocking inducements did not outweigh the negative impacts on the herder , thus explaining the continued over-stocking . Other people have trouble , but can learn with a bit of trial-and-error practice . I 'll not send along the bank statement , but I fear that now Yale will , every year , forward the statement to me - - for the rest of my life . Issues such as zoonotic diseases ( those from animals ) , globalization , migration and increased travel , climate change , anti-microbial resistance , trend to resist vaccines all have , or could have a dramatic impact on the health care system and the health of Canadians . The study will ( 1 ) evaluate the significance of biofilm formation in scouring-related sites ; ( 2 ) determine the effect of sediment biofilms on the sediment-water mixture , in terms of the entrainment and initiation of sediment motion , rate of sediment transport , and the near-bed velocity distribution ; and ( 3 ) assess the environmental problems that may arise from a sediment biofilm area that is subjected to scouring . Mr. Gonggrijp 's argument seems to be that the hackers could not have really broken in , as the system was reasonably well protected . So , the alternative answer to your question might be that the frequency of O alleles has always been sort of high , and that it has not necessarily risen over the course of human history .