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The group of Moshe Oren is studying the regulation of p53 protein stability , which is the major mechanism responsible for the in vivo modulation of p53 function . A searchable protein database , ARABI-COIL ( http://www.coiled-coil.org/arabidopsis ) , was established that integrates information on number , size , and position of predicted coiled-coil domains with subcellular localization signals , transmembrane domains , and available functional annotations . Podocytes therefore forms the final barrier to protein loss , which explains why podocyte injury is typically associated with marked proteinuria . Such a substitution would likely have little or no effect on the protein product , but in the appropriate location , this alteration will seriously impact the phenotype .