[lemma=and | tag=□] □
[lemma=and | tag=VB] □
To be actived , a B-cell must receive costimultion in the form of two disparate signals : signal one occurs when the number of pathogens binding to a B-cell 's receptors exceeds the affinity threshold ; signal two is provided by helper T-cells . For example , he does not make clear why he prefers his time-delay neural network ( TDNN ) method to other available methods or why we should expect it to work well in this case . This overview will focus on the acquired immune system because it is the most complex , and has potentially the most interesting solutions to offer computer science . It has to be the most complex , because any pathogens that manage to evade the previous layers in the body 's defenses will be much harder to detect and eliminate , i.e. they will be much better adapted to evading the body 's defenses . The Title IX / Affirmative Action Coordinator shall establish a complaint file .