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Our results indicate that some probe sets should not be considered as unique measures of transcription , because the individual probes map to more than one transcript dependent upon the biological condition . Our data strongly support a model whereby the injury-elicited calcium wave is required for wound healing [ 60 ] , and indicate that the subnormal propagation of the calcium wave in Pax6 + / - corneal epithelia underlies the wound-healing delay . Epithelial sheets react to mechanical injuries via a complex process that relies on coordinated proliferation and migration into the denuded area , matrix deposition and tissue remodeling [ 13-16 ] . By the principle of protein sequence Rosetta Stones [ 41 ] , these fusions suggest a functional relationship between their respective domains and may further support a proposed role for EpsH homologs in the processing and sorting of PEP-CTERM proteins . The principle of using the phylogenetic profile of a DNA cis-regulatory site to identify a DNA-binding protein was demonstrated in the case of the NrdR-box associated with ribonucleotide reductase genes ; leading to the identification of the NrdR-box binding protein [ 45 ] . Heterozygous deficiency in PAX6 leads to ocular surface disease characterized by corneal opacification ( aniridia-related keratopathy ; ARK ) , and the Pax6 + / - mouse model displays all the morphologic defects of human ARK [ 4-7 ] . Increased drug use among psychotic patients may also come from an attempt to counteract nonspecific physical symptoms or side effects of neuroleptics [ 27 ] . Recent data indicate that chronic use of coxibs leads to an increased occurrence of thrombotic cardiovascular events .