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The following conditions may be associated with forms of Total Lipodystrophy : Acanthosis Nigricans ( a skin disorder characterized by gray or black darkening and thickening of the skin which occurs frequently in Lipodystrophy patients around the onset of puberty ) , Acromegaly ( gigantism ) , excessive hair growth ( hirsutism or hypertrichosis ) , eruptive yellowish spots on the skin , and thickened skin . The condition occurs frequently in juvenile diabetics and is the leading cause of new blindness among U.S. adults . Acanthosis Nigricans ( a skin disorder characterized by gray or black darkening and thickening of the skin which occurs frequently in Lipodystrophy patients around the onset of puberty ) , is usually present . Well , the notion of human dignity occurs frequently in Catholic moral thinking , especially in some of the social teachings issued in recent years and is , therefore , a notion that I've had to confront regularly and with which I have had to grapple .