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It has not been yet explained to most of the natives whom it affects as it should have been , and a vast number of natives have no explanation of it at all , but have commenced to feel its cruel effects . " Leslie , after her first anguish was over , found it possible to go on with life after all , as most of us do , no matter what our particular form of torment has been . Although the respective secretaries of state have discretion to switch funds within their block , it must be consistent with overall government policy . " People of all ages and in a variety of organizations have been enriched by his wisdom , common sense and humor . To illustrate the above themes , we will discuss how our view of mutation has evolved through experimental analysis .