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An approach is needed that allows for : ( i ) uncertainty in the field data that is used for validation ; ( ii ) simultaneous comparison of the outcomes in terms of multiple predicted variables ; ( iii ) assessment of the trajectories by which models arrive at final outcomes as well as those outcomes themselves ; and ( iv ) incorporation of other information that may not be amenable to formal quantitative evaluation but that enables model performance to be constrained . In those patients who refuse surgery or are not surgical candidates the following options may be considered : Radiation therapy may be used as a treatment of recurrent disease or as primary therapy to avoid mutilating surgical resection.Pharmacologic therapy with antiestrogens and prostaglandin inhibitors may also be used.In cases of recurrent extra-abdominal desmoid tumors in which surgery is contraindicated or in cases of recurrence , a chemotherapeutic regimen of doxorubicin , dacarbazine , and carboplatin may be effective.Surgical Care : Aggressive , wide surgical resection is the treatment of choice.Complete surgical excision of desmoid tumors is the only effective method of cure . " Average " values of the climatic input may be satisfactory for most simulations , but the user should also test the effect of extreme conditions . But in the great majority of cases , namely , with all organisms which habitually unite for each birth , or which occasionally intercross , the individuals of the same species inhabiting the same area will be kept nearly uniform by intercrossing ; so that many individuals will go on simultaneously changing , and the whole amount of modification at each stage will not be due to descent from a single parent . The Episcopal Conferences are to review their statutes in order that they may be consistent with the clarifications and norms of the present document as well as the Code of Canon Law , and they should send them subsequently to the Apostolic See for recognitio , in accordance with canon 451 of the Code of Canon Law .