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Mammary tumors reported in the MMTV-Neu monotransgenic line used here have usually acquired mutations in the Neu coding domain of the transgene , enhancing the enzymatic activity of its product ; about 70 % of these tumors exhibit point mutations , small deletions , or insertions in the extracellular portion of the receptor in or near the cysteine-rich domain encoded by nucleotides 1492 – 2117 of rat Neu cDNA [ 17 ] . Another important difference between the experiments is the size of the wounds , which were very large ( 1000 – 1200 μ m ) in the study by Ramaesh et al [ 59 ] , encompassing up to half the cornea and encroaching on the limbal region . Some researchers have claimed [ 8 ] that atypicals are of comparable efficacy to typical antipsychotics of medium or low potency , because lower-potency antipsychotics have a more favorable EPS profile , and thus provide greater tolerability and better outcomes . If the head of household was not available , another adult member of the household was asked to answer to the questions .