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[lemma="half-life" | □] □ □
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Because aortic dissection is more common in elderly patients ( ie , aged 70-80 y ) , this group of patients has different comorbidities . Chronotropic incompetence ( failure to achieve 85 % of age-predicted maximum heart rate ) is more common in elderly patients ( 407 ) , and both it and a hypotensive response to exercise are ominous features , as shown in other age groups . This benzodiazepine hypnotic has an extremely long half-life in elderly patients ( often days ) , producing prolonged sedation and increasing the incidence of falls and fractures . In elderly patients ( over 65 years of age ) , the Cmax was similar to that of patients 65 years of age or younger , but the clearance in elderly patients was reduced by approximately 13 % . Age : A variety of neurological conditions common in elderly patients ( multiple cerebral infarcts , Alzheimer disease , parkinsonism ) may exacerbate the manifestations of PSE ; however , the condition usually is prominent in patients with advanced liver disease , which may not manifest in very elderly persons because they do not survive .