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The amendment also states that a notice of appeal filed before the disposition of any of the posttrial tolling motions becomes effective upon disposition of the motions . This project , sponsored by The National Institutes of Health ( NIH ) , the National Institute of Neurological Disorders and Stroke ( NINDS ) , and the ALS Association , was a focused effort to fast-track new therapeutic strategies against ALS into the clinic . Both Rule 4 ( b ) ( 4 ) and the Advisory Committee Note to the 1998 amendment make it clear that an extension can be granted for either excusable neglect or good cause , regardless of whether a motion for an extension is filed before or during the 30 days following the expiration of the original deadline . Following the drug screening effort for new therapies against ALS , Dr. Andrea Vincent , Ph.D ., obtained a grant from the ALS Association to study the protective drug effects . Their research will be supported by state-of-the-art information technology which will allow them to explore and collaborate like never before . The subdivision applies to appeals from " an order regarding release or detention " of a criminal defendant before judgment of conviction , i.e ., before sentencing . It also permits the parties to stipulate against transmission of designated parts of the record without the fear that an inadvertent stipulation may " diminish " the record . Therapies targeted against this interaction will provide new strategies to halt disease progression . The Center seeks to facilitate interaction between researchers from across the University , enhance collaborative studies and speed the translation of basic science findings into clinically useful therapies for metabolic diseases including obesity , type 2 diabetes and related metabolic disorders . That sentence , like the parallel provision in Rule 4 ( a ) ( 4 ) , was intended to toll the running of time for appeal if one of the posttrial motions is timely filed . Subdivision ( a ) governs appeals from bail decisions made before the judgment of conviction is entered at the time of sentencing . Civil Rules 50 , 52 , and 59 , are being revised to require filing before the end of the 10-day period . On Sunday , Sept. 10 in Ann Arbor , the renowned marathon runner Bill Rodgers , a four-time winner of both the New York City and Boston marathons , 1976 Olympian and member of the U.S. Track & Field Hall of Fame joined the marathon fight against diabetes , by acting as master of ceremonies for our fourth annual Race for Reason .