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More than 1,750 of the total TBI-injured have sustained moderate enough TBI to have neurosensory complications . Diffuse cerebral swelling following pediatric TBI may be a significant contributor to increased intracranial pressure ( ICP ) , which can result in further ischemia and potential uncal herniation . Recently , increases in the cerebrospinal fluid levels of endothelin-1 were observed early after severe TBI in infants and children . Of significance to intimate violence and TBI is the examination of the type of blow delivered to the head and the resultant type of TBI incurred , with numerous studies on boxers providing correlative information .