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Protein intake was adjusted at 0.6 g / kg / day with calories at 45 kcal / kg / day . Reduced activity was seen at 1 g / kg in mice and at 5 g / kg in rats . Some patients who show excellent tolerance to FOSCAVIR may benefit from initiation of maintenance treatment at 120 mg / kg / day earlier in their treatment . In nonpregnant rats dosed at 135 mg / kg / day for 7 days , systemic exposure ( AUCs ) for losartan and its active metabolite were approximately 66 and 26 times the exposure achieved in man at the maximum recommended human daily dosage ( 100 mg ) . Patients receiving cefotaxime and albumin at 1 g / kg / day experienced a lower risk of renal failure and a lower in-hospital mortality rate than patients treated with cefotaxime and conventional fluid management . Seizures can occur at 60 mg / kg and mild signs such as vomiting , diarrhea , bloating and restlessness can occur at only 20 mg / kg ( ASPCA / APCC Database : Unpublished data ) .