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The regulations will take effect 30 days after publication in the Federal Register . The Medical Library Association strongly supports the NIH proposal to provide freely available online access to NIH-funded manuscripts via PubMed Central not later than six months after publication in a peer-reviewed journal . The final rule includes a new 60-day comment period , and becomes effective 90 days after publication in the Federal Register . The regulations shall be effective sixty days after publication in one issue of the Connecticut Law Journal and shall at all times be subject to amendment or revision by the committee . Further , given the provisions of the Export Apple Act , it is found and determined upon good cause , that it is impracticable , unnecessary , and contrary to the public interest to postpone the effective date of this rule until 30 days after publication in the Federal Register . Reply comments are due within 90 days after publication in the Federal Register . 553 , it is also found and determined upon good cause that it is impracticable , unnecessary , and contrary to the public interest to give preliminary notice prior to putting this rule into effect and that good cause exists for not postponing the effective date of this rule until 30 days after publication in the Federal Register because : ( 1 ) Making this change effective prior to that date will facilitate Committee operations ; ( 2 ) this issue has been widely discussed at various industry and association meetings , and interested persons have had time to determine and express their positions ; and ( 3 ) this rule provides a 60-day comment period and any comments received will be considered prior to finalization of this rule .