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Updates are classified into high priority , software , and hardware . KP1 : The first few amino acids are part of the distal part of the signal peptide cleavage recognition site . " So , Tau mutations may also be involved in other dementia disorders . Since the same feature was observed in cis amide bonds in small molecule structures found in the Cambridge Structural Data Base , a new set of parameters for the refinement of protein structures containing non-Pro cis peptide bonds is proposed . To this end it is necessary to use and expand physical and psychological models , and to acquire new model data by physical measurements and psychological studies .