[□] □ □
[□=□] □ □
[□ | □] □ □
Financial difficulties are compounded by the limitations on parents ' options to increase the family income through work . " The risks are compounded as the data spreads , " she said . In NBIA , the challenges of gene therapy are compounded by the need to deliver the correct gene across the blood-brain barrier and into the brain . Some of the legal issues are compounded by the lack of technical solutions . ASD , unlike other serious illnesses , are compounded by the fact that appropriate resources to treat the malady are either unavailable or insufficient . In a corporate environment - - where these pressures are compounded by the need to prove ourselves to our superiors - - anything short of forging ahead seem unacceptable .