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Plasma cholesterol levels greater than 200 mg / dl or less than 120 mg / dl - includes patients with diagnoses such as familial hypercholesterolemia , familial combined hyperlipidemia , sitosterolemia , lipoprotein lipase , hepatic lipase or apo-CII deficiency , and dysbetalipoproteinemia . ( 3 ) Diabetes mellitus is one of the conditions that leads to incomplete metabolism of VLDL , causing increased remnant VLDL or IDL observed in dysbetalipoproteinemia ( see Dysbetalipoproteinemia ) . Elevated triglycerides also impart high risk when associated with a high ratio of LDL to HDL cholesterol or when due to one of two inherited conditions - - familial combined hyperlipidemia or dysbetalipoproteinemia . A genetic test subsequently confirmed that he had familial dysbetalipoproteinemia , a condition that occurs in about 1 in 10,000 people . Plasma LDL-C levels greater than 130 mg / dl or less than 70 mg / dl - includes patients with diagnoses such as familial hypercholesterolemia , familial combined hyperlipidemia , lipoprotein lipase , hepatic lipase , or apo-CII deficiency , sitosterolemia , dysbetalipoproteinemia , abetalipoproteinemia and hypobetalipoproteinemia .