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This is particularly true when considering refinement alternatives since they are often techniques which are not specific to particular research or teaching goals and are not necessarily found in discipline-specific literature . Since influenza peaks most often in January and February , vaccination is encouraged through the winter months . This disability has been misunderstood for hundreds of years , but it affects more men then women and it often runs in the family . This process often creates further damage to the relationship between parents , and this , in turn , can be traumatic for , and detrimental to children .