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They have been shown in various tissues to modulate signaling and gene activation in response to short-lived endocannabinoid ligands or THC . Content validity was assured by the involvement of clinical experts at all levels of the translation process . Findings were unchanged following correction for multiple comparisons ( Step 4 ) . Five interviewer teams , each comprising one male and one female interviewer , and four local supervisors did the field work . Current findings are , however , inconsistent with a meta-analysis by Wahlbeck and colleagues [ 35 ] , who reported lack of significant differences in dropout rates between typicals and atypicals other than clozapine . psychotic symptoms ) , interviewing skills , training on the screening-instrument and field work under close supervision of experts . Furthermore , our core findings on differential effectiveness between typicals and atypicals are highly consistent with those found in prior RCTs [ 9-11 ,15,42 ] , in retrospective claims database studies [ 4,21,43,44 ] , and in naturalistic prospective studies [ 4,30 -33,40 ] . Current findings are consistent with several core findings from the CATIE trial [ 14 ] . The local supervisors received additional training on the random sampling method . Several endogenous natural ligands of the CB receptor family termed endocannabinoids have been described . These findings were not statistically significant , likely due to much-reduced statistical power ( change from 85 % power for comparisons versus other atypicals to 58 % power versus ziprasidone ) . Following the random direction until the border of the cluster was reached , all houses on the right side within a range of 15 meters were numbered .