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Fold changes induced by estrogen and tamoxifen treated MCF-7 cell lines for unique genes that are down-regulated ( n = 54 ) or up-regulated ( n = 30 ) by HRT in breast cancer patients . In addition , the presence of many tumor cells with myoepithelial features ( for example , expression of smooth muscle actin ) and other observations suggest that in the Wnt pathway oncogenes transform cells positioned early in the developmental program for mammary tissue , whereas oncogenes like ErbB2 / Neu that activate Ras proteins , either transform cells that are more advanced developmentally or drive cells to a more mature epithelial character during oncogenesis . Lower : three surface views from a different orientation ; the middle image has all of the subunits other than the second largest subunit as a semi-transparent surface so that the position of the two intein insertion sites on the interface between RPB1 and RPB2 ( red and blue regions ) can be seen . Each line has a unique histocompatibility profile , while the two sublines SA02.5 and BG01V are identical to their parental lines . Virtually all clinical developmental studies in infants have examined visual and cognitive outcomes [ 19 ] , and are limited to sampling of blood for assessment of tissue responses to supplementation , rather than the target CNS tissues . Our results indicate that some probe sets should not be considered as unique measures of transcription , because the individual probes map to more than one transcript dependent upon the biological condition . Equally important , by providing data in the same format on a new post-9 August line , it facilitates the direct comparison of lines eligible and ineligible for federal funding to determine which cell line is best suited to the individual researcher 's needs . The FLAME algorithm has intrinsic advantages , such as the ability to capture non-linear relationships and non-globular clusters , the automated definition of the number of clusters , and the identification of cluster outliers , i.e. genes that are not assigned to any cluster .