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Previous research has established the absence of target medication for more than 14 days as a valid indicator of drug discontinuation [ 4,21 ] . The B group DHA was significantly greater than the others in three regions but , uniquely , less than a supplemented group ( P + ) in the corpus callosum . The three topologies tested are colour-coded as follows : red , T1 topology , i.e. the placement of the clade before the divergence of the Streptophyta and Chlorophyta ; blue , T2 topology , i.e. the placement of the clade as sister to the Streptophyta ; and green , T3 topology , i.e. the placement of the clade as sister to the Chlorophyta . PEP-CTERM and LPXTG-mediated processes would differ , as the cell envelopes of Gram-negative and Gram-positive bacteria differ , however , the similarity of the observed triad of conserved residues in EpsH and sortase suggests that , like sortase , EpsH may be involved in the proteolysis ( transpeptidation ) of the associated proteins . It was perhaps expected therefore that the links between Pax6 and cell behavior would be pleiotropic , with a complex etiology intractable to mechanistic investigation . Thus , we decided to use the more unspecific terms ' cases with psychotic symptoms ' or ' psychotic symptoms ' rather than ' schizophrenia ' or ' drug-induced psychosis ' . If so , tumors might arise earlier in MMTV-Wnt1 / MMTV-Neu bitransgenic mice than in mice carrying a single transgene , and any cells that acquired H-Ras mutations would not have a selective growth advantage ; hence H-Ras mutations would not be detected in our tests of tumor genotypes . Measures of identity and stability are generally of less concern to researchers growing hESCs than are the potency and undifferentiated state of the cells . On average , cases with psychotic symptoms had started to use khat earlier in life than matched controls and had been using khat 8.6 years before positive symptoms emerged . For example , we have estimated that at least 20 % of the population must carry a genetic abnormality before it can be detected by a SNP array ( data not shown ) . Tissue height of stria vascularis was normal ( Fig. 5 ) , consistent with the similar numbers of 18S rRNA molecules in isolated preparations ( see above ) . Therefore we suppose that retrospective assessment of khat intake is more valid than that of food intake . Larger wounds in Pax6 + / - corneal epithelia healed faster than smaller wounds ( presumably because larger wounds were closer to the source of proliferating limbal stem cells ) , and extrapolation from figure 2 in that study [ 59 ] suggested that wounds smaller than 500 μ m in diameter would heal more slowly than wild-type . Khat consumption ( average number of bundles / day ) was assessed for the week before the interview and for the week prior to the onset of symptoms in examined cases . Local interviewers found that rates of severe disability due to mental disorders were 8.4 % among males ( above the age of 12 ) and differed according to war experiences ( no war experience : 3.2 % ; civilian war survivors : 8.0 % ; ex-combatants : 15.9 % ) . The observation that tissue masses were lost in the spiral limbus region is consistent with the finding of a reduced number of 18S rRNA molecules in the spiral ganglia preparation ( see above ) . As described above , in the whole-eye culture system , the corneal epithelial migration is modulated by the presence of an inflamed stroma , which would be expected to accelerate cell migration over extended periods of healing . The position of the six RNA polymerase intein insertion sites mapped onto the crystal structure of the RNA polymerase II of Saccharomyces cerevisiae . We therefore asked whether we could detect H-Ras mutations in mammary tumors induced by an MMTV-Wnt1 transgene in a p53-null background ; a failure to find such mutations would imply either that p53 is somehow required for such mutations to occur or , more likely , that an inherited deficiency of p53 conferred a growth advantage to Wnt1-expressing mammary cells that would outweigh any selective advantage provided by a secondary somatic mutation in H-Ras . But assuming that this error is somehow the same for the whole sample , our finding that the group of society that engages most in khat chewing ( males above the age of 12 ) most often suffers severe impairment due to mental disorders shows evidence that khat is related to mental health problems .