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It ranks high among the least pertinent things I have ever said , because Hughes 's true seriousness is based on exactly that : his ability to transmit the highest level of aesthetic enjoyment through the popular media , one of which , of course , is the best seller . It was about 36 celsius and high elevations . His endowments of this spot alone might at any time have placed him high among the benefactors of the convent . But if the five kids from Hyde Park High were nervous , they did n't show it . There was no shortage of problems : high unemployment , high rates of alcoholism , high dropout rates for high school students , and chronic health problems like diabetes . Leaving the high elevations of the mountains and hills and entering the flat plains , the river slows down . The " auld slave-driver " knew that his name did not stand high among his peers , and his imagination was keen enough to supply the details of the gossip of which his cousin gave so pleasant a summary . We have characterised the function of TFB in high detail by using a range of assays that measure the discrete steps of transcription initiation , such as RNAP-recruitment , closed-to-open complex formation , abortive initiation and productive transcription .