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Scientists have demonstrated that these recombinant vaccines activate the immune systems of rodents and nonhuman primates , eliciting both antibody-type immunity and killer cell-type immunity against a variety of disease-producing organisms . " Nevertheless , some immunologists wonder if suppressing the generalized activation of the immune system might even be beneficial to people with HIV , although no study has yet shown this . HIV apparently destroys these helper cells and over time , the immune system begins to fail . Soluble interleukin-2 receptor concentrations , CD4 + cell count , cytotoxic T cell count , and gamma interferon – positive lymphocytes have been used to assess the role of the immune system in de Quervain thyroiditis . ADA and PNP deficiencies : These are associated with enzyme deficiencies in the purine salvage pathway ; toxic metabolites are responsible for the destruction of lymphocytes that cause the immune deficiency .