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Using rigorous study designs and analytical methods , scientists have established with a high degree of certainty the causal role of tobacco in disease and death . If diagnosed early , this type of porphyria can be treated with a high carbohydrate diet and the addition of heme through an I.V. The Classical and Renaissance Venus 's physicality and sexuality , though , are treated with a high degree of civilized restraint . The town is cormpassed with a high and thick wall , in which there are many towers and forts ; there is also a broad and deep dry ditch , set thick with thorns , cast round three sides of the town , and the river is instead of a ditch on the fourth side . In spite of the lack of archeological data about the location of the items found , most documents can be attributed with a high degree of certainty .