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These rocks have been moved by faulting to up above the main rift valley floor . The ability to up - or down-regulate the actions of parathyroid hormone could help patients with hyperparathyroidism , wherein an excess of the hormone causes so much calcium removal from bone that bone density is severely impaired . ) You will be prompted for your slate password when you connect to the sever to up - or down-load your web site files . The major problems with TABOR stem from the rigidity and fundamental flaws in the formulas , resulting in under-funding of essential services and limiting the government ’ s ability to adjust to up - and down-turns in the economy . Wightman , whose store is in Manhattan , said a UPS service known as Alternative Delivery Location , part of the UPS Corporate Retail Solutions program , requires franchisees to deliver packages , often without specific information as to the contents , to UPS customers who are utilizing the alternate location service . You wrote , " The way in which you describe diabetes leads us to believe that you have not had access to up - to-date information about the disease and some of the issues confronting people with diabetes . Accordingly , the organ specificity of the two different isoenzymes of PK makes it possible to up - and down-regulate glycolytic processes in the organs to a different intensity dependent on the two abiotic factors . Energy costs are down 4.3 percent on a year-on-year basis compared to up 15.1 percent in August . " Consumer spending was steady to up moderately , with a number of Districts noting sluggish auto sales .