[□] □ □
[□=□] □ □
[!□] □ □
Further dose intensification may be achieved by enhancing the activity of chemotherapeutics or increasing the susceptibility of the tumor cells to chemotherapy toxicity by decreasing endogenous glutathione concentrations , or by inhibiting enzymes which deactivate chemotherapeutics . Then we propose a new technological issue which would greatly enhance these activities . Fundamental to this definition is the premise that funds raised by student organizations are to be used to expand or enhance the activities of those organizations and not to financially subsidize an individual 's personal interests or needs . Since prohibitin is known to repress the transcriptional activity of E2F family members and enhance the activity of p53 protein , we decided to examine the effect of prohibitin on gene expression .