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The WHO , in a large-scale risk assessment that combined the results of many studies , compared the global burden of illness and premature death from major risk factors , including outdoor air pollution , tobacco smoking , unsafe water and sanitation and others . International cooperation to promote research and development , mobilize investment , create markets or share experiences could form a powerful tool to strike while the iron is hot . In urban areas , pollution alerts are an important tool in warning the public of days with high pollution levels . These were the writers who prompted Nathaniel Hawthorne 's notorious comment , in an 1855 letter to his publisher , that " America is now wholly given over to a d - - - - d mob of scribbling women . Bassi , among the most attractive of the nineteenth-century Italian patriots , is described by the eleventh edition of the Encyclopaedia Britannica as " a gentle , unselfish soul , who , although unusually gifted , had an almost childlike nature . I hope that you will find this edition both stimulating and informative .