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" ( b ) Necessity of certificate of probable cause for appeal . We have found that insulin-like growth factor I ( IGF-I ) , rescues neurons from cell death , so we believe that IGF-I could be used to interrupt the death pathway . Before reopening the time for appeal , the existing rule requires the district court to find that the moving party was entitled to notice of the entry of judgment and did not receive it " from the clerk or any party within 21 days of its entry . " This change broadens the type of notice that can preclude reopening the time for appeal . The $ 50 is for everyone who registers for the one credit hour class , and also for those who come along as an anthropology club activity even if they do not need the one credit and thus do not register for the class . Our central hypothesis is that IGF-I present within bone interacts with the IGF-IR in neuroblastoma , contributing to bone metastasis in childhood neuroblastoma . For the reasons explained in the Note accompanying Rule 4 , that rule makes the time for appeal in bankruptcy cases the same as that which obtains in other civil cases and thus supersedes Section 25 . In both cases the PAH remained extractable by organic solvents but were not available for biotransformation along one of the biological degradation pathways ( mineralization , humification ; Fig. 1 ) . We speculate that high glucose probably kills cells in a number of steps , and that IGF-I blocks one or more of these distinct steps . To facilitate the processing of your application , we ask that your recommenders send the letters of recommendation directly to us by fax ( 734-764-8180 ) or U.S. Mail .