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The route of administration should be the most appropriate having regard to the likely route of human exposure , the acute toxicity and the nature of the substance . A large portion of female patients have metastases to the lower extremities . I just simply want to call the attention of youths and of their youth organization to the significance that this may have , to the significance that this has , to the immense lack of realism that this entails , and to an unquestionable gap , one for which we are all to blame , all of us , all of us who in any way may have some influence over youth , and this includes mass organizations , political organizations , mass means of communications , in short , all the factors that could lead a group of human beings to have a real attitude toward life and toward the future . Several of the banks have extensive nationwide branch networks and all of the banks have exposure to the areas affected by the earthquake , namely Izmit , Bursa and Adapazari . They should have exposure to the presentation and management of gravidas experiencing acute hypertensive crises , espcially those crises complicated by systemic manifestations such as liver dysfunction , thrombocytopenia , and microangiopathic hemolytic anemia . Animals that drank barium over long periods had damage to the kidneys , decreases in body weight , and some died . In some tests , the animals had damage to the nerves in the central nervous system . Jackett C.J ., in Nanda v. Public Service Commission , [ 1972 ] F.C. 277 ( C.A. ) at 297 , interprets " merit " to mean that , the best persons possible will be found for the various positions in the Public Service " having regard to the nature of the service to be performed " . One had damage to the facial nerve that controls movement of the face . In addition , the reason advanced does not bear critical scrutiny having regard to the programme in operation in the Western Cape , KwaZulu-Natal and the significant expansion of the programme in Gauteng . In light of the reputation and goodwill which the Plaintiff has gained internationally and in Jamaica through the operation of numerous McDonald 's restaurants throughout the world and the extensive use and advertisement of the Plaintiffs trade name , trademarks , logos and get-up , which have become distinctive of the business operated and the products and services sold at the restaurants operated by the Plaintiff and its licensees , and having regard to the fact that the Plaintiff has announced and extensively advertised and promoted the opening of their first restaurant in Jamaica , the acts of the Defendants in using signs and advertisements bearing the name " McDonald 's " and using an arched " M " that is a colourable irritation of the Plaintiffs registered trademarks are acts calculated to deceive the Jamaican public and are likely to cause confusion in the minds of the Jamaican public and other persons on the island who are familiar with the restaurants operated by the Plaintiff and its licensees and the food sold and service rendered at those restaurants .