□ □
[□] □
□* □
As ACSH has pointed out many times , even if a substance is toxic at high doses , trace amounts are not therefore dangerous . The morning-after pill contains a high dose of the most common ingredient in regular birth-control pills . The book provides detailed , site-specific information on applications and techniques of brachytherapy in the head and neck , central nervous system , breast , thorax , gastrointestinal tract , and genitourinary tract , as well as on gynecologic brachytherapy , low dose rate and high dose rate sarcoma brachytherapy , vascular brachytherapy , and pediatric applications . High dose animal testing is used by every public health agency around the world , from EPA to European bureaus to the World Health Organization - - and even by industry when it likes the results ( for example when these studies prove the safety of drugs , cosmetics , or other pesticides ) . In a 24 month oral carcinogenicity study in mice dosed with 10 mg / kg / day drospirenone alone or 1 + 0.01 , 3 + 0.03 and 10 + 0.1 mg / kg / day of drospirenone and ethinyl estradiol , 0.1 to 2 times the exposure ( AUC of drospirenone ) of women taking a contraceptive dose , there was an increase in carcinomas of the harderian gland in the group that received the high dose of drospirenone alone . In patients with an activated renin-angiotensin system , such as volume - and / or salt-depleted patients receiving high doses of diuretics , symptomatic hypotension may occur . Because the high doses of chemotherapy can destroy the bone marrow , marrow is taken from the patient 's bones before treatment . First , all of the bone marrow in the body is destroyed with high doses of chemotherapy with or without radiation therapy . This may be intrathecal chemotherapy alone or combined with either radiation therapy to the brain or high doses of systemic chemotherapy to treat or prevent leukemia in the brain . A review by the National Toxicology Program found that only 6 % of all chemicals analyzed caused cancer at the high dose only ( Rall 1994 ) .