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These results indicated a protective effect of THC against destruction of host cells by the virus and suggested that THC may inhibit MHV 68 replication . Initiation and propagation of the calcium wave could be largely decoupled , and both phases of the calcium wave responses were required for wound healing . The NTERA-2 line also has advantages for antibody-based comparisons , as the line is well adapted to culture and grows quickly without feeder layers , attachment matrices , or the addition of any specialized growth factors other than serum . Addition of exogenous epidermal growth factor ( EGF ) to wounded Pax6 + / - cells restored the calcium wave , increased ERK1 / 2 activation and restored the immediate healing response to wild-type levels . The intensity of the calcium response quantitatively controls the subsequent rate of healing in some epithelial cells , and remodeled calcium signaling may underlie disease states such as diabetes , hypertension , heart disease , manic depression and Alzheimer 's disease [ 30-32 ] . The initiation of the calcium wave ( the immediate large calcium rise in cells surrounding the wound ) was normal in Pax6 + / - cells , but the propagation was defective . EpsH is a putative membrane protein based on its eight predicted transmembrane segments and is found within a large exopolysaccharide biosynthesis locus . Congenital aniridia caused by heterozygousity at the PAX6 locus is associated with ocular surface disease including keratopathy . The second abnormal observation was also found at the D13S317 locus in the line SA02 . All participants signed a written informed consent , which was first read and explained to them ( as most of the participants were illiterate ) .