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Therefore , it is often not possible to apply conventional in vitro toxicokinetic techniques , and it remains necessary to use carefully controlled in vivo assays of exposure to estimate the effective tissue dose ( s ) integrated over time . Bernard was second in the five-member de Jussieu dynasty of botanists who occupied for nearly a century and a half a pre-eminent place in botanical science . Boitard and Corbie , whose experience extended over forty-five years , state : " Quand une femelle eprouve de l'antipathie pour un male avec lequel on veut l'accoupler , malgre tous les feux de l'amour , malgre l'alpiste et le chenevis dont on la nourrit pour augmenter son ardeur malgre un emprisonnement de six mois et meme d'un an , elle refuse constamment ses caresses ; les avances empressees , les agaceries , les tournoiemens , les tendres roucoulemens , rien ne peut lui plaire ni l'emouvoir ; gonflee , boudeuse , blottie dans un coin de sa prison , elle n'en sort que pour boire et manger , ou pour repousser avec une espece de rage des caresses devenues trop pressantes . Net et al. believed that volcanic ash deposited subaqueously in quiet water conditions became devitrified and altered to clay ( bentonite ) which was then metamorphosed to pyrophyllite to form these deposits . Intracytoplasmic sperm injection ( ICSI ) is a component of infertility treatment often employed when conventional in vitro fertilization is unlikely to be successful . net et al ) I feel very lucky . ) That 's not to imply that it 's a sickness , since it poses no biological threat , nor is it genetic per se , nor is it dangerous to the safety of society like psychopathic behavior ( also chemical based of course .