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They found a single mutation in a gene called MET , which is known to be involved in brain development , regulation of the immune system and repair of the gastrointestinal system . However , the name could not be found in more recent works on the subject , and Tumanova 's book is known to be outdated . An enzyme called COX-2 ( cyclooxygenase-2 ) is known to be involved in the cause of pain , inflammation , and stiffness related to arthritis . Perhaps more money on education would mean less money would be needed for prisons ; we could try to reverse the trend toward growing inequality which is known to be associated with rising crime . Some wild male sand goby exhibited morphological abnormalities in the uro-genital papilla ( UGP ) , an organ which shows secondary sexual characteristics and is known to be involved in gamete deposition . Professor Holton and Miss Dukas have kindly provided us with the information , recorded in Chapter II , concerning the correspondence with persons active in quantum physics which is known to be included in the collection . 56 , 72 , and 73 ) , and because viscosity is known to be affected by food processing procedures or , following ingestion , by the digestive system in ways that are unpredictable ( Refs .