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At slightly higher doses ( in the range of 50-200 ppb , commonly found in drinking water from contaminated wells in New Hampshire and elsewhere in the U.S. ) arsenic has the exact opposite effect , strongly and almost completely inhibiting hormone-stimulated gene expression by these receptors . If sampling demonstrates that arsenic exceeds the MCL , a CWS will be triggered into quarterly monitoring for that sampling point `` in the next quarter after the violation occurred . In metallurgy the inclusion of 0.5 - 2 % arsenic improves the sphericity of lead shot ( McKee and Wolf ) . Toxic releases from manufacturing facilities are a public health threat in the Commonwealth , where risk score for cancer cases attributed to manufacturing releases such as arsenic is the seventh highest in the nation . While other endocrine disrupters interfere with the binding process , arsenic alters the complex so it ca n't turn on genes , says Hamilton .