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The primary function of the national-level affordability criteria is to determine whether affordable compliance technologies are available for all size categories of small systems , or , alternatively , whether EPA should list a variance technology and thus grant flexibility to states to make affordability determinations for variance purposes on a case-by-case basis . If we know the genetic code for a section of the gene of interest , or , alternatively , if we know the amino acid sequence of the enzyme we are looking for , then we can construct synthetically a section of nucleotides which can serve as a probe . One could argue that the center is in New York and London , because that 's where the allocation of capital is determined , or , alternatively , it resides in the central banks of the United States , Japan and Germany , because that 's where the cost of capital is determined . [ 1 ] Initiatives are best described as procedures instituted and controlled by voters to make new laws via the constitution , or , alternatively , by enacting statutes .