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Consumer demand for contraband - - particularly tobacco and alcohol products and expensive items such as luxury automobiles - - is especially high in countries where high-import tariffs and excise taxes add significantly to the price of legitimate sales . In oral mucosa , etiologic agents - - especially tobacco and alcohol , and possibly some viruses - - are known to induce alterations in the genes and gene functions associated with cell cycle regulation , contributing to the development of squamous cell carcinoma and epithelial dysplasias . In Conley , the judge ruled as a matter of law that the jury could not reasonably return a verdict for the plaintiffs , and entered a verdict in favor of the defendants - - Reynolds Tobacco and Philip Morris . Today smokeless tobacco comes in two forms - - chewing tobacco and snuff . The fees the lawyers collected fed the pot for attacking politically unpopular industries - - from tobacco and firearms to HMOs .