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From there , they boarded American Airlines Flight 11 , which crashed into the north tower of the World Trade Center . Wednesday 34th Street west of Madison Avenue was blocked to traffic , ostensibly because icicles were falling from the radio tower of the Empire State Building , and anything falling from that height could flatten a pedestrian like a moth in a keyboard . The office tower of the MRISC Building is integrated with the Cancer Facility for Women and provides clinical evaluation space and chemotherapy / infusion services , plus the headquarters for the Women 's Health Initiative .