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Site-directed mutagenesis in the mouse , colloquially known as gene knockouts , provides a powerful method for testing the influence of specific genes of interest on a wide variety of physiological and behavioral traits . Butrint and its setting should be carefully preserved as a major historical and natural attraction ; investment should be concentrated in and around the busy little Ionian port of Saranda , the ferry link to Corfu . " Unfortunately the hot spots on the southern coast have n't fared as well , with falls generally less than 10mm . " These were not designed as words for the politically squeamish , but they mark a key moment in the unfolding of the crisis .