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In another randomized trial in which patients with standard risk ALL were randomized to receive PEG-L-asparaginase versus native E coli asparaginase in induction and each of 2 delayed intensification courses , the use of PEG-L-asparaginase was associated with more rapid blast clearance and a lower incidence of neutralizing antibodies . The tightening of monetary policy , supported by the exchange rate anchor , produced in the short term an impressive reduction in inflation and a significant improvement in confidence in the ruble . Investigations of adsorption properties of an In atom , an As atom , and an As2 molecule by the first-principles calculations imply that the observed adsorbates are an In atom and an As2 molecule . Other factors impacting further progress in improving AI / AN health status are the increases in population and the rising costs of providing health care . The steady increase of the US economy in the 19th Century was mainly endogenous , relying on the substantial increase in population and the innovation in technologies and social organization modes . The immediate future requirement of food expressed in terms of energy for the world 's population is derived from the growth in population and the need to provide an equitable supply of food for each person . No matter how they come out , however , they are having a ventilating effect on thinking in evolution and the conventional dogma is being challenged .