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Genes expressed aberrantly due to amplification are involved in cell cycle regulation , apoptosis , angiogenesis , transmembrane signaling , and resistance to chemotherapeutic agents . Thus Bmi-1 dependence is conserved between stem cells and distinguishes the cell cycle regulation of stem cells from the cell cycle regulation of at least some types of restricted progenitors . Finally , on an organ and organism level we study the integration of cell cycle regulation in organ growth and function .