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The two references to the Apocalypse in Botticelli 's inscription remind us that just before the half millennium there was an outbreak of that fear of universal destruction which had afflicted men 's minds five hundred years earlier , and from which we are not altogether free as the year 2000 approaches [ nb - originally published in 1960 . We examined the effects of THC on the replication of MHV68 and HVS , two rhadinoviruses related to KSHV and to lesser extent to EBV . On the contrary , during the interviews our greater fear was that households would over-report the presence of mentally challenged family members . " Golding , " Cubism , A History and an Analysis , 1907-1914 " : " [ I ] n the spring of 1911 Braque introduced a new element into one of his paintings which was of vital significance . For each ' examined case ' a matched control , who did not meet the criteria for disability due to mental health problems , was identified .