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We address the structural features of the kinase domain and the unique polo-box domain of PLK1 that are most suited for drug development and discuss our current understanding of the therapeutic potential of PLK1 . The concluding sentence , here , is an excellent example of one of the most ingeniously malignant of critical ruses - that of condemning an author , in especial , for what the world , in general , feel to be his principal merit . The TSA attempted to expand its no-fly and selectee lists , despite the fact that passengers often have no reliable way of finding out how to correct errors on their records . This happens because , after successive failures , their leaders , rather than reexamine their fundamental premises , since these provide the rationale for their existence , prefer to implement them more ruthlessly in the conviction that failure was due to insufficient resolve .