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ZO-1 and F-actin expression revealed a continuous layer of basal cells , including a junction of basal cells with surface epithelial cells in Slc26a4 - / - mice , as observed in normal mice ( Fig. 1c ,1 d ,1 e ,1 f ,6,7 ) . Content validity was assured by the involvement of clinical experts at all levels of the translation process . " The composition is classically simple , a large shallow space with a cluster of figures on the left balanced by a wall and a window on the right . With the reduction of painting to nothing but the canvas itself , and the rising popularity of performance and video art , it truly seemed for a brief moment that painting indeed may have been in its final death throes as part of an epochal change . Proceeding down the list of matched genomes , the relative counts of YES and NO states were scored at each point for the probability P that the current count y of YES genomes , or greater , could have been encountered by chance among the N genomes encountered so far , as calculated from the binomial distribution .