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The goal of my laboratory is to understand how the regulated localization of signaling proteins contributes to the generation of distinct signals required for T cell activation . Thus , the second major research focus of my laboratory exploits mouse models to elucidate the role of γ - H2AX , other biochemical modifications of chromatin , and chromatin-associated proteins in the repair of chromosomal DSBs . Based on this success , a major focus of my laboratory is to continue to exploit gene-targeted mutation and RAG-deficient blastocyst complementation to investigate and understand the molecular mechanisms that promote TCR β locus accessibility . A major focus of my laboratory is determining the structural elements and molecular mechanisms that underlie the kinetics , stoichiometry and stability of serine protease-serine protease inhibitor ( serpin ) interactions .