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Left ventricular stroke work index , pulmonary capillary wedge pressure , and central venous pressure all remain unchanged . However , moderate exercise or any factors that increase heart rate and cardiac output increase the mitral valve gradient and thus pulmonary wedge pressure , resulting in exertional dyspnea . That is , they responded to pressure , apparently , from the Kremlin political handlers . Recipients of images or of substitute checks will not have the original pieces of paper to examine , for weight , or texture , or pen pressure , or fingerprints . Physiological changes included sustained increases in mean pulmonary artery pressure , pulmonary vascular resistance , pulmonary arterial wedge pressure , heart rate , hematocrit , and the arterial partial pressure of carbon dioxide . Vowing not to bend to pressure , we continued on . The knot is sometimes sensitive to pressure , and it may gradually thicken and begin to pull one or more of your fingers toward the palm . But the South African regime is highly vulnerable to pressure , especially from the United States , the United Kingdom and West Germany on which it has become dependent . It can feel like uncomfortable pressure , squeezing , or viselike pain . Will Google and other search engines be pressured , and succumb to pressure , to keep closed systems closed ? " Because of grassroots pressure , P & G is now more accountable to the needs of impoverished coffee farmers .