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With the exception of the well-characterized PKA-target sites , little is known regarding the relationship between the phosphorylation of specific sites in the alpha and beta subunits and the corresponding effects on the structure / activity of the holoenzyme . Overall , the members concluded that the methods and assumptions used to project the status of the Medicare program were reasonable , with the exception of the long-range expenditure growth assumption , which they believed to be too low . It is true that we cannot hope too much to enrich ourselves from the acquisition of great art works of paintings and sculptures , with the exception of the Veit-Stoss altar , and the plates of Hans von Kulnback in the Church of Maria in Cracow .... Under the able management of Superintendent Lee the penitentiary has been an d is a model penal institution , and with the exception of the unfortunate escapes of last June , and which under existing conditions could not have been avoided , the results have been satisfactory in every particular .