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Patients could continue with medications they received prior to enrollment for as long as necessary , and decisions about medication changes , if any , reflected those made by physicians and their patients , as they naturally occur in usual practice . In late adulthood , beginning about age sixty five , we decide how , or even whether , to continue making a contribution to the social world at large . More importantly , the behavior of cells and their phenotypic state changes as culture conditions and the stress to which they are subjected is altered , and permanent genomic changes frequently occur as passage numbers increase [ 5-7 ] . Based on our data , we divide wound healing into an immediate period of 2 hours when calcium and MAPK signaling occur to initiate a rapid migratory response , and the subsequent ' post-initial ' coordinated movement of epithelial sheets when cell migration is maintained . Infections among Swedish travellers correlate well with national studies conducted in the countries visited . Our results indicate that some probe sets should not be considered as unique measures of transcription , because the individual probes map to more than one transcript dependent upon the biological condition . There are two on the margins , who blow on their sea-shells , and two pairs in front and behind , who are making love to each other . The connections between tissue stem cells and aging are still controversial , but it has been demonstrated that changes in mitochondrial properties correlate with reduced competence of adult stem cells [ 27 ] .