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This finding may not apply to other topical verapamil preparations ; however , the authors make a strong case against the use of topically applied verapamil without EMDA . The deadlines shown below are applicable to all parties involved in a capacity release process ; however , they are only applicable if 1 ) all information provided by the parties to the transaction is valid and the Replacement Shipper has been determined to be credit worthy , pursuant to Section 16 of these General Terms and Conditions , before the capacity release bid is tendered and 2 ) there are no special terms or conditions of the release . Renal biopsyIn general , kidney biopsy is not necessary in the initial evaluation ; however , if prerenal and postrenal causes have been ruled out and an intrinsic renal disease other than prolonged ischemia , nephrotoxin , or postinfectious glomerulonephritis is suspected , renal biopsy may be valuable in establishing diagnosis , guiding therapy , and providing prognosis . Looking Forward 's increasing tuition models assumed that the student loan system would grow in step with tuition increases ; however , despite recent federal and provincial announcements , student aid continues to be cut and a strong new student loan system has not been established .