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Pseudoephedrine is primarily excreted unchanged in the urine as unchanged drug , the remainder is apparently metabolized in the liver . The patent-conferred monopoly lets drug companies charge astronomical sums for their products . In a response to this article , Major and colleagues wrote that although HIV seems to be controlled peripherally by drug therapy , many of the antiretroviral drugs have great difficulty penetrating the blood brain barrier , and cannot get into the brain in significant enough levels to affect the viral loads there . This document was created from RTF source by rtftohtml version 2.7.5 > <title> Ariail Drug Co. v. Because we conclude that we do not have jurisdiction to review the order . ART is a combination treatment of antiretroviral drugs and drugs that prevent cell death . Antiretroviral drugs has also been shown to alter methadone metabolism and increase methadone levels . Antihistamine metabolites and small amounts of unchanged drug are excreted in the urine . A wide range of clinical drug trials and other types of research studies are offered for older adults with Alzheimer 's disease , other types of dementia , behavioral disturbances , depression and other psychiatric disorders . Cognitive testing , medical monitoring and study medicines are offered at no cost to qualified participants of clinical drug trials .