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Lower : three surface views from a different orientation ; the middle image has all of the subunits other than the second largest subunit as a semi-transparent surface so that the position of the two intein insertion sites on the interface between RPB1 and RPB2 ( red and blue regions ) can be seen . CLOE represents a simple and effective data mining approach that can be easily used for meta-analysis of cDNA microarray experiments characterized by very heterogeneous coverage . The cell layer was then overlaid with a lysis solution containing SDS and pronase resulting in gentle cell lysis and liberation of cellular and viral DNA . Cell cultures were incubated for 48 h. For every protein found in the three analyzed complexes , and represented by at least one EST probe in both datasets , we selected the most representative human and mouse probes .