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Over the long term , however , the pinching maneuvers may contribute to development of osteoarthritis in the thumb , index , and middle fingers . Over the long term this will also help to lower the cost of pharmaceuticals and primarily in the fact that it will help to give a little bit more certain atmosphere for conducting the business transactions necessary for the smaller companies to get the capital to do the studies later on . We believe this bill in the long term will serve the province of Manitoba well . Far more important than when students study algebra is what they study and whether they are taught in a way that helps them learn it and use it for the long term . Aneshensel and Huba suggest that the immediate effect of alcohol is to relieve depressive symptoms but that the long term effects is increased depression .