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Faculty , fellows , and trainees have published work on sleepiness , its measurement , insomnia , snoring , obstructive sleep apnea , other forms of sleep-disordered breathing , restless legs syndrome , periodic leg movements during sleep , REM sleep behavior disorder , sleep in patients with epilepsy , effects of asthma on sleep , interactions between sleep and immunity , hormones and sleep , cognitive problems associated with sleep disorders , behavioral effects of sleep disorders , effects of alcohol on sleep , sleep laboratory methods , questionnaires used to screen for sleep disorders , and many other topics . In the study , 34 participants with late-stage diffuse high grade glioma , a type of brain tumor , underwent diffusion MRI before beginning a new treatment involving chemotherapy , radiation therapy or a combination . Dr. O'Brien 's research focuses on sleep in children , sleep-disordered breathing , cognitive and behavioral consequences of sleep apnea , sleep in children with craniofacial disorders , William 's Syndrome , and sleep during pregnancy . Through the UM Center for Sleep Science , the clinical Sleep Disorders Center members also collaborate with some of the nation 's leading scientists dedicated to basic research on how the brain produces sleep , and on critical interactions between sleep and breathing , pain , immunity , inflammation , and memory . His clinical interests include the evaluation and treatment of sleep-disordered breathing , narcolepsy , parasomnias , and restless leg syndrome . In order for chemotherapy to treat a tumor , it must penetrate this barrier . Modern researchers recognize that the C , R , E , and T occur in all patients with systemic sclerosis ; thus we classify the disease based on the extent of involvement of the skin – limited versus diffuse . Further , phosphorylation of hsp27 has been shown to correlate with smooth muscle contraction , while phosphorylation of hsp20 ( another member of the small heat-shock protein family ) correlates with smooth muscle relaxation . If you feel there is a change in your breathing , inform your physician . The studies showed the nanoparticles traveled to the tumor , resulting in less Photofrin exposure throughout the body and enhanced exposure within the tumor .