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Changes within the large intestine may result in chronic constipation , fecal impaction , and bowel obstruction . Acid in the large intestine may lead to pain , which leads to opiate release , which leads to cribbing . The cause of ulcerative colitis remains unknown , but in theory , the immune system in the mucosa of the large intestine may be triggered by the many antigens from food products and billions of bacteria that live there . The large intestine may be a reservoir for L. monocytogenes in humans . Intestinal obstruction involving the small or large intestine may plague a patient with progressing ovarian cancer . Sections of the small or large intestine may be removed . In affected males , the urinary opening ( meatus ) may appear on the underside of the penis ( hypospadias ) ; the testes may fail to descend into the scrotum ( cryptorchidism ) ; and / or portions of the large intestine may protrude through an abnormal opening in muscles of the groin ( inguinal hernia ) . The large intestine may be a reservoir for Listeria monocytogenes in humans .