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It has recently been suggested that ARK may be due to corneal epithelial fragility combined with an abnormal wound-healing response [ 12 ] , resulting in degeneration of the cornea . In the case of mentally challenged participants , background and procedure were also explained to the responsible caretakers whose written informed consent was a prerequisite for their participation . Processing is completed when the LPXTG protein is attached covalently through an amide bond at its new carboxyl terminus to a peptidoglycan precursor , lipid II [ 13 ] . The gene-expression profile of pluripotent hESCs has not been completely defined , but much work has been carried out toward defining common sets in undifferentiated and differentiating hESCs [ 12-14 ] . Of 2327 participants , most completed 1 year of follow-up ( 78.1 % ) , with fewer completing 2 years ( 69.6 % ) , and 3 years ( 65.2 % ) . Two very large , naturalistic , prospective , 3-year studies have been recently completed , reporting findings consistent with US-SCAP . Prophylactic use was defined as a prescription for an anticholinergic medication written on the same date as , or 1 day later than , the initiation date of haloperidol . The first panel ( uppercase ) in each pair is a dorsal view of the anterior end of a juvenile , the second ( lowercase ) is a magnified view of the dissected mantle edge . All interviews were carried out in October and November 2002 . Hence , it is suggested that the failure in Pax6 + / - cells is due to slow or inefficient release of calcium from stores . Clinical interviews were carried out by some of the authors ( MO , MS , CC , BL ) , all trained in the assessment of psychotic disorders and PANSS rating . All participants signed a written informed consent , which was first read and explained to them ( as most of the participants were illiterate ) . Our estimate of testing costs for this characterization scheme is that these can be completed for a single line for approximately $ 2500 .