[lemma=for | tag=PRP | tag=□]
[lemma=for | tag=PRP | tag=IN]
[lemma=for | tag=PRP | tag=PRP]
Unlike treatment with other antipsychotics , treatment with clozapine requires periodic blood monitoring to assess the risk of developing agranulocytosis . On average , cases with psychotic symptoms had started to use khat earlier in life than matched controls and had been using khat 8.6 years before positive symptoms emerged . Among these proteobacterial , PEP-CTERM positive genomes , the observation of this motif is universal . During the same time period , an increase in the same phage type had also been registered among Norwegian and Finnish travellers returning from Greece [ 17 ] . Pendrin-expressing surface epithelial cells in the spiral prominence region are located in an area where basal cells , which are interconnected by tight junctions , form additional tight junctions with surface epithelial cells [ 29 ] . Furthermore , it seems that it is not the consumption of khat per se but rather specific patterns of it that are related to psychosis , especially early onset in life and the excessive intake ( > two bundles per day ) . In addition , with bitransgenic mice , we could ask whether a co-existing MMTV-Wnt1 transgene eliminated the selective advantage conferred by an activating mutation in the coding domain of the MMTV-Neu transgene , and we could ask whether the phenotype of tumor cells in resulting tumors resembled the phenotype of tumors induced by components of the Wnt pathway , the Neu / Ras pathway , or both . However , unlike aspirin , some , but not all patients , treated chronically with naproxen maintain suppression of thromboxane throughout the whole dosing interval at a level compatible with effective platelet inhibition [ 10,11 ] . We hypothesized that if " sponsor-related physician bias " were present , physicians would have quickly switched patients from their current antipsychotic to olanzapine rather than to risperidone ( olanzapine , risperidone , and clozapine were available for all patients at the time of enrollment , unlike quetiapine and ziprasidone that were not yet available to early study enrollees ) . Results were essentially unchanged when the Cox Proportional Hazards regression model was repeated ( a ) using 1 medication episode per patient ( n = 1028 ) , the one with which the patient was treated first , ( b ) using 1703 treatment episodes , including episodes where patients simultaneously initiated 2 or more treatment episodes , ( c ) using the time elapsed between medication initiation and patients ' enrollment in the study , as a proxy for potential " sponsor-related physician bias , " ( d ) using a medication gap > 14 days to assess robustness of the > 30-day medication gap used to signal medication discontinuation , and ( e ) using ITT analysis , with 2488 treatment episodes , thus not requiring initiators to have continued in the study for at least 1 year following medication initiation . This result has two implications : that the presence of an inherited MMTV-Wnt1 transgene strongly diminishes any selective advantage conferred by secondary somatic mutations in the Neu transgene , and that expression of a wild-type version of the Neu transgene is sufficient to provide the growth advantage that is apparently conferred by secondary somatic mutations of H-Ras in MMTV-Wnt1-induced tumors . Physician perception ( Phy per ) , Patient perception ( Pt per ) . For example , we have estimated that at least 20 % of the population must carry a genetic abnormality before it can be detected by a SNP array ( data not shown ) . The fifth and last sensitivity analysis was an intent-to-treat ( ITT ) analysis , which unlike previous analyses also included initiators on the index drug who did not have data for at least 1 year following initiation . tRNA genes are indicated by the one-letter amino acid code ( Me , elongator methionine ; Mf , initiator methionine ) followed by the anticodon in parentheses . In most cases with psychotic symptoms , a pattern of binge use ( > two ' bundles ' per day ) preceded the onset of psychotic symptoms , in contrast to controls of the same age . Proceeding down the list of matched genomes , the relative counts of YES and NO states were scored at each point for the probability P that the current count y of YES genomes , or greater , could have been encountered by chance among the N genomes encountered so far , as calculated from the binomial distribution . Among the PEP-CTERM domain-containing species we discuss , it is only the members of the Proteobacteria that share these conserved DNA motifs . The three topologies tested are colour-coded as follows : red , T1 topology , i.e. the placement of the clade before the divergence of the Streptophyta and Chlorophyta ; blue , T2 topology , i.e. the placement of the clade as sister to the Streptophyta ; and green , T3 topology , i.e. the placement of the clade as sister to the Chlorophyta . Using an episode-of-care approach provides comprehensive information about the multiple courses of treatment per participant in the longitudinal treatment of the illness [ 20 ] . With the exception of one region , the B group DHA concentration was always among the greatest , while the P - group was always among the lowest .