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Patients with early disease may have normal range of motion with progressive loss of lumbar flexion as the disease progresses . If the creatinine concentration is outside the normal range of 0.5 g / L to 3.0 g / L , the urine sample may be too dilute or concentrated to be reliable . These effects were only seen when large populations were studied and tended to be within the normal range of variation . In the second study , European researchers targeted hemoglobin levels to the normal range of 13 to 15 grams per deciliter for 226 people with chronic kidney disease .