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The mechanism was not Hebbian but similar in principle : it involved " temporally contiguous " activation of the sensory neurone ( CS ) and a modulatory synapse ( UCS ) , with a presynaptic rather than postsynaptic connection ( as in a classic Hebb synapse ) . Dynamic extent means that the binding lasts as long as the activation of the construct that established it . He noted that interactions between the domains of some sub-units were stronger than others , and he subsequently concluded that inter-domain interactions control the rate of activation of the G proteins . Numerous studies indicate that insomnia is accompanied by excessive activation of the stress-response system not only during waking hours but during sleep as well . Takematsu et al showed that disruption of the epidermal wall of molluscum bodies induces acute inflammatory changes by activation of the alternative complement pathway on exposure to the tissue fluids ; furthermore , the molluscum bodies release proinflammatory cytokines and other neutrophil chemotactic factors on decomposition .