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Table 5 presents the hazard ratios ( HR ) and 95 % confidence intervals of time to all-cause medication discontinuation of each atypical agent versus all the typicals using the Cox Proportional Hazards regression model . This contrasts sharply with the report by D'Cruz et al. [ 3 ] of mutations affecting mostly K-Ras and also N-Ras , but never H-Ras , in mouse mammary tumors induced by an MMTV-c-Myc transgene . Processing is completed when the LPXTG protein is attached covalently through an amide bond at its new carboxyl terminus to a peptidoglycan precursor , lipid II [ 13 ] . The fact that dozens of families approached the compound of our collaborating partner agencies in order to find help for their mentally ill members ( often they brought them in chains to the compound ) shows the great need for mental health services . LPXTG proteins are cleaved and become bound , covalently but transiently , to the active site cysteine of sortase [ 11 ] . The left side of each coronal section represents the left hemisphere . For random selection the geographical center of each cluster was determined and a random direction was chosen using a compass , a watch and a list of random numbers between 1 and 12 ( a watch was oriented according to the compass , whereby 12 o'clock was adjusted to North ; the random number defined the direction according to the hours on the face of the clock ) . To further assess the robustness of the findings , sensitivity analyses were performed , including the use of ( a ) only 1 medication episode for each patient , the one with which the patient was treated first , and ( b ) all medication episodes , including those simultaneously initiated on more than 1 antipsychotic . But assuming that this error is somehow the same for the whole sample , our finding that the group of society that engages most in khat chewing ( males above the age of 12 ) most often suffers severe impairment due to mental disorders shows evidence that khat is related to mental health problems . Furthermore , antipsychotic switching processes are often characterized by medication overlap with cross-titration , which amounts to short-term ( and at times prolonged ) antipsychotic polypharmacy , thus making true monotherapy treatment episodes relatively rare and possibly not representative of the complex treatment regimens in real-world practice . For example , the expression profiles of tumors reflect the transgenic oncogene [ 5 ] ; moreover , those tumors induced by genes that activate the Ras signaling pathway ( for example , polyoma middle T antigen , ErbB2 / Neu , and H-Ras ) are more similar to each other than to tumors induced by components of the Wnt signaling pathway ( Wnt1 , β - catenin , and c-Myc ) with respect both to gene expression patterns ( [ 5 ] , S. Huang et al ., in preparation ) and to cellular composition and histology [ 6-9 ] . Some have reported comparable efficacy [ 12 ] and questioned the claims of superior efficacy of atypicals relative to typicals [ 8,12,13 ] because clinical trials have often established efficacy of the atypicals in comparison to haloperidol , a high-potency typical antipsychotic known to have pronounced treatment-emergent extrapyramidal symptoms ( EPS ) that may contribute to poorer treatment outcomes . Pax6 + / - mouse corneal epithelia exhibited a 2-hour delay in their response to wounding , but subsequently the cells migrated normally to repair the wound . However , as soon as he is released the patient engages again in ( often excessive ) khat consumption until symptoms relapse and he is restrained again .