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The major hormones modulating linear growth ( growth hormone , thyroid hormones and gonadal steroids ) have different effects on bone maturation . Regarding the note in bold at the bottom of the major and minor proposals , there could be only 6 here . " The award was established to honor those who have made a major contribution to the field of human-computer interaction . The various provisions of the CFS described above have made a major contribution in this regard . One change is that both the major and minor proposals now say that two courses used to fulfill requirements in another major or minor may count toward meeting requirements of the LACA major or minor . Their review of the major rheumatic diseases integrates the cellular , biochemical , and molecular biological mechanisms that are important in rheumatic disease pathogenesis .