[word=at] | [tag=FW] | [tag=DT | □]
[word=at] | [tag=FW] | [tag=DT | □=□]
[word=at] | [tag=FW] | [tag=DT | □ & □]
Proceeding down the list of matched genomes , the relative counts of YES and NO states were scored at each point for the probability P that the current count y of YES genomes , or greater , could have been encountered by chance among the N genomes encountered so far , as calculated from the binomial distribution . There is growing interest in naturalistic studies that compare , among other variables , the differences in treatment duration between specific atypical and typical antipsychotics . It has been shown from the analysis of multiple alignments and crystal structures that there is a high correlation between clusters of the most highly conserved residues in an alignment and functional sites ; this relationship has been observed to be strongest for enzyme catalytic sites , rather than protein-protein and protein-DNA interaction sites , and to apply best when the overall conservation observed in the alignment is low [ 38 ] . Overall , however , there is significant correlation between a protein 's degree in the two data sets ( τ ≈ 0.53 ) . Expression of key proteins involved in the generation of the endocochlear potential and the transport of K + was studied using confocal immunocytochemistry and quantitative RT-PCR . This random organization is specifically altered by cells from tumor explants as the cells contract and reorganize the collagen matrix . A total of 331 non-redundant ESTs were clustered using ClustalW and placed into one of five categories according to ( i ) the presence / absence of a signal sequence , whether they are ( ii ) a trafficking protein , ( iii ) a transcription factor , ( iv ) a signaling molecule or ( v ) have no identity with existing sequences in GenBank . Using confocal immunocytochemistry on cryosections , we observed strong expression of the pendrin protein in the apical membrane of vestibular transitional cells in the utricle and ampullae ( Fig. 1g ,1 h ,1 i ) . Representation of S. cerevisiae RNA polymerase II ( PDB : 1I3Q ) ; the second largest subunit is coloured dark grey ( other subunits , including the largest , are coloured light brown ) . The three topologies tested are colour-coded as follows : red , T1 topology , i.e. the placement of the clade before the divergence of the Streptophyta and Chlorophyta ; blue , T2 topology , i.e. the placement of the clade as sister to the Streptophyta ; and green , T3 topology , i.e. the placement of the clade as sister to the Chlorophyta . Following injury , cells directly adjacent to the wound edge rapidly increased [ Ca2 + ] i , but subsequent wave propagation was prevented ( Figure 4A , C ; see Additional file 3 ) .