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Pulse rate was significantly depressed by the higher doses of OXY following HAL , but was not changed by MEP following either anesthetic . It also prolongs prothrombin time and anesthetic agents ' effects . Therefore , surgical and anesthetic management require careful planning . PCP , developed in the 1950s as an intravenous surgical anesthetic , is classified as a dissociative anesthetic : Its sedative and anesthetic effects are trance-like , and patients experience a feeling of being " out of body " and detached from their environment . As one writer put it , it is “ neither anesthetic bliss nor the repose of a graveyard . Tolterodine tartrate ( Detrol ) also acts as both an antispasmodic and anesthetic . The variants = slot contains a code indicating the inflectional morphology of the entry ; the filler reg in the noun entry indicates that the noun " anesthetic " is a count noun which undergoes regular English plural formation ( " anaesthetics " ) ; inv in the variants = slot of the adjective entry indicates that the adjective " anesthetic " does not form a comparative or superlative . The suture was the most painful step - - an indicator that the cold " anesthetic " had worn off . Available evidence suggests that use of sedative and anesthetic drugs in the dental office by appropriately trained professionals has a remarkable record of safety . Blood pressure was not changed by either anesthetic nor was it influenced by MEP or OXY . In this eutectic mixture , both anesthetics are liquid at room temperature ( see DESCRIPTION ) and the penetration and subsequent systemic absorption of both prilocaine and lidocaine are enhanced over that which would be seen if each component in crystalline form was applied separately as a 2.5 % topical cream .