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Four-drug ARV regimens might help improve response , but this has not been demonstrated . In addition , BChE has been demonstrated to be involved with the metabolism of cocaine and , therefore , may be important in preventing neurotoxicity from this drug . To further demonstrate interactions between antiretrovirals and psychotropic agents , Dr. Greenblatt described a four-part study involving trazadone and ritonavir at a dose of ritonavir high enough to inhibit cytochrome P450 ( CYP ) 3A but not to induce it . It has been demonstrated that if the farmers of the country adopted the Wisconsin milking methods they would increase their profits one hundred million dollars a year . Police on foot , bicycles , squad cars , horses and motorbikes have swamped the one-mile ( 1.6-km ) route between downtown and the fence-ringed Staples Center in a dual mission to protect property and discourage potential troublemakers demonstrating on issues ranging from forest logging to the death penalty . An increased ejection fraction has been demonstrated in children and adults using both drugs . In NHGRI s opinion , raw human genomic DNA sequence , in the absence of additional demonstrated biological information , lacks demonstrated specific utility and therefore is an inappropriate material for patent filing . A few phenomena demonstrate the different arrangement , motion , and interaction of particles in the three states of matter ( Idea e ) ( e.g ., the motion of gas particles , course 2 , chapter 14 , pp . Although it has been demonstrated that a linear relationship exists between relaxation times and water content , only relative measurements are available .