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Previous research has established the absence of target medication for more than 14 days as a valid indicator of drug discontinuation [ 4,21 ] . Influence of removing increasing proportions of fast-evolving sites in the amino acid data set on the robustness of the nodes supporting the Chlorokybus + Mesostigma clade and the three possible positions identified for this clade . The three topologies tested are colour-coded as follows : red , T1 topology , i.e. the placement of the clade before the divergence of the Streptophyta and Chlorophyta ; blue , T2 topology , i.e. the placement of the clade as sister to the Streptophyta ; and green , T3 topology , i.e. the placement of the clade as sister to the Chlorophyta . These include the potential period bias , episode bias , and the potential for preference of the sponsor 's medication ( olanzapine ) over other atypicals by participating physicians . Namely , the 1-year survival rate for patients randomized to olanzapine was significantly higher than it was for patients randomized to typical antipsychotics of high - , medium - , or low-potency levels , and compared to perphenazine .