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The third sensitivity analysis assessed " sponsor-related physician bias " by including the new covariate just described : the time elapsed between medication initiation and the patient 's enrollment date in the study . Nevertheless , local changes in the allele intensity ratio ( theta ) are seen in chromosomes 12 , 17 , and a portion of chromosome X of BG01V , chromosome 13 of SA02 , and within the q arm of chromosome 1 in H9 . Both the unsupervised and supervised learning paradigms benefit from the explicit inclusion of these intermediate distance matrices , and particularly so in the latter case , which offers a better balance between sensitivity and specificity in the prediction of protein-protein interactions . The percentages of PT 4 and PT 6 among human S. Enteritidis infections in Austria and Denmark , respectively , have been reported to be decreasing in the last years [ 6 ] . A total of 331 non-redundant ESTs were clustered using ClustalW and placed into one of five categories according to ( i ) the presence / absence of a signal sequence , whether they are ( ii ) a trafficking protein , ( iii ) a transcription factor , ( iv ) a signaling molecule or ( v ) have no identity with existing sequences in GenBank . A request on Enter-Net ( European network for the surveillance of enteric infections – Salmonella and VTEC O157 ) sent by the Norwegian Public Health Institute gave no response on increases of PT 14b in other countries .