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Low sequence identity is found for the EpsH family , with an overall percent identity of only 25 ( particularly low considering its hydrophobic nature ) . The strongly hydrophobic nature of EpsH family proteins seems more reminiscent of transporters than of proteases , but there is abundant precedent for protein sorting processes that depend on proteolytic cleavage and other processing by highly hydrophobic proteins . To clarify the question of how continued khat consumption might affect the further development of psychotic symptoms , the number of relapses related to khat intake would be of tremendous importance . The hydrophobic nature of EpsH marks it as a probable membrane protein . Case controls were asked about consumption in the week prior to the interview and for consumption at the age of symptom onset reported by his / her examined case-pair ( Table 2 ) . This pool shows great concordance of expression with individual normal hESC lines , as the correlation coefficients ( r2 ) with normal lines average 0.87 , or 0.93 for genes expressed at high confidence levels . Given the importance of PPIs , we suggest that submission of PPIs to repositories be made mandatory by scientific journals at the time of manuscript submission as this will minimize annotation errors , promote standardization and help keep the information up to date . However , although a perfect design is not possible in a rather complex field situation , the importance of such studies is evident from the fact that little or no information from post-war Somalia is available . Consensus on the importance of continuous treatment with antipsychotics has been accompanied , however , by an ongoing debate over whether the newer " atypical " antipsychotics are superior to the older " typical " antipsychotics in the treatment of schizophrenia [ 8-13 ] . However , THC has been also proposed to influence cellular function by other mechanisms due to its hydrophobic nature and likely association with lipid structures such as cell membranes [ for review , see [ 17,18 ] ] . Khat consumption ( average number of bundles / day ) was assessed for the week before the interview and for the week prior to the onset of symptoms in examined cases . Khat consumption ( number of bundles / week ) was assessed for the week prior to the interview . There were no significant differences between the genotypes.SBP , systolic blood pressure ; DBP , diastolic blood pressure ; HDL , high-density lipoprotein ; HR , heart rate ; LDL , low-density lipoprotein . Some methodological shortcomings of the study are related to the nature of field work in this specific post-conflict setting , which involved restricted freedom of movement due to the security situation and limited resources .