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Deposition of the prion protein ( an abnormal isoform of a native cellular sialoglycoprotein ) in the central nervous system is a reliable marker for infection , and immunohistochemical detection of this marker is a useful adjunct to histopathology . The elder aunt , Mrs. Goldbrook , did not share her sister 's character as a human rest-cure ; most people found her rather disturbing , chiefly , perhaps , from her habit of asking unimportant questions with enormous solemnity . It was important that she make a stunning first impression . I took a few steps back . It certainly was not turning out a comfortable or auspicious dinner party .