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Studies in vitro have shown that chemokine receptors can bind multiple ligands and that each chemokine can bind to multiple receptors . It may act on peripheral nerves , but CB2 receptors have not yet been found there ; it may act in some way to inhibit the release of chemicals like prostaglandins from immune cells that increase sensitivity to pain ; or they may cause immune system cells to release substances that block the pain response . Examples of each type of coupling including receptor structure and interaction with ligand eg nicotinic acetylcholine receptor for ion channels . On the other hand , Inp2p functions as the peroxisome-specific receptor for the class V myosin , Myo2p , thereby linking peroxisomes to the translocation machinery that propels peroxisome movement . Progesterone receptors have been identified in the female reproductive tract , breast , pituitary , hypothalamus , and central nervous system . A second important property of the NMDA receptor is that its opening is blocked by a single magnesium ion ( Mg2 + ) . These drugs have side effects because they affect receptor sites that cause the depressive symptoms , and some that do not . Some members of the Toll-like receptor ( TLR ) family , which is found from plants to insects and humans , directly activate key components of the inflammatory cascade upon interaction with microbial cell wall glycolipids . Lack of iron appears to affect dopamine receptors in the brain .