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The largest group of people affected by the condition is active boys and men in the 10 - to 20-year age group who are participating in organized sports . With the exception of thioridazine , many phenothiazines possess antiemetic activity , including chlorpromazine given in the 10 - to 50-mg dose range orally , intramuscularly , intravenously , and rectally ( pediatric dose for older than 12 years old : 10 mg every 6-8 hours ; for younger than 12 years old : 5 mg every 6-8 hours ) ; thiethylperazine given in the 5 - to 10-mg dose range orally , intramuscularly , and intravenously ; and perphenazine . It is usually given in the 10 - to 50-mg dose range ( pediatric dose : 6 mg every 4-6 hours ) .