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The sounds for which the single Gaussian appeared less appropriate are those such as which occurs in two quite different contexts in the digit data . However , these same devices are less appropriate for maneuvering your spaceship through an asteroid field while shooting down imperial battle cruisers . The first two have been used successfully with the freshman and sophomore students in both universities and two-year colleges ; the third level moves away from the dialog format , and thus is less appropriate for this classroom technique . " In September 2006 , REMICADE was approved in the U.S. for the treatment of adult patients with chronic severe ( i.e. extensive and / or disabling ) plaque psoriasis who are candidates for systemic therapy and when other systemic therapies are medically less appropriate . Survey Unit experience suggests that whether to include such a middle option is best assessed on a case by case basis as it may be less appropriate for certain subject matters , also , in some cases it may be necessary to include a ' not applicable ' or ' not experienced ' option instead of or even as well as your ' middle alternative ' .