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The principle of interval mapping ( Lander and Botstein , 1986 ) is that segregating markers nearest to a target gene remain linked with the target and tend to become homozygous when it becomes homozygous . The sole work on the program was Mahler 's Symphony No. 3 , performed by the American Symphony Orchestra under the direction of Leon Botstein , Bard 's president and the music director of that ensemble . New York State invested $ 5 million , to be distributed over five years by the Empire State Development Corporation Botstein also stipulated that the main theater be flexible , accommodating everything from intimate chamber concerts to expansive opera productions . Princeton , for example , has the Lewis-Sigler Institute for Integrative Genomics , led by former Stanford genetics Professor David Botstein . In his vision to change this , Botstein set the bar high .