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The sum of the square mismatch between the predicted and actual TF time course relative to the one obtained using the actual gene control network shown in Table 1 . Braque had first introduced letters into a still life , probably of early 1910 , but they are blended into the composition and have no function other than that of identifying as a newpaper the object over which they are painted ... Tumors in these mice arise after a latency of similar length , have similar growth characteristics , and metastasize to the lungs with similar frequencies regardless of whether they do or do not contain a mutant H-Ras gene ( data not shown ) . Some scratch marks are visible on the underbelly of the central horse ; however , in painting the riders and horses , Degas 's penmanship changed again . The sum of the square mismatch between the predicted and actual TF time course ( relative to that obtained using noise-free microarray data ) as a function of the amplitude of random noise added to the microarray data . For example , the expression profiles of tumors reflect the transgenic oncogene [ 5 ] ; moreover , those tumors induced by genes that activate the Ras signaling pathway ( for example , polyoma middle T antigen , ErbB2 / Neu , and H-Ras ) are more similar to each other than to tumors induced by components of the Wnt signaling pathway ( Wnt1 , β - catenin , and c-Myc ) with respect both to gene expression patterns ( [ 5 ] , S. Huang et al ., in preparation ) and to cellular composition and histology [ 6-9 ] . We do not have an explanation for these differences in mutation spectrum and do not know whether they reflect differences in mutational rates at Ras loci ( for example , as a consequence of environmental exposures ) , differences in the selective advantage conferred by different mutant Ras proteins in cells expressing different oncogenes , or differences in the genetic backgrounds of the mouse lines used . Comparison of predicted and observed microarray response for arcA .