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All studies also include arachidonic acid ( ARA ) to prevent any possible negative effects on growth reported in early studies [ 20 ] . Each column corresponds to a patient labeled according to survival ( = recurrence ; defined as distant metastases or death within 5 years of diagnosis ) , Elston grade 3 , and lymph node status , where gray symbols indicate missing values . Therefore , DNA microarrays represent a fundamental tool to unravel biological complexity on a genome-wide scale . Furthermore , many individuals classified as " chronic users " of naproxen in this general population may not have been compliant with the required dosing regimen ( twice a day ) all throughout the period of prescribed drug intake further diluting the benefit of an " aspirin effect " . Top : surface view showing the position of the cleft formed by the two largest subunits and the position of the four intein insertion sites ( indicated by different colours ) on the surface of the cleft , near the active site / " wall " region . Consensus on the importance of continuous treatment with antipsychotics has been accompanied , however , by an ongoing debate over whether the newer " atypical " antipsychotics are superior to the older " typical " antipsychotics in the treatment of schizophrenia [ 8-13 ] . Although taxonomic filtering was used to minimize the bias introduced by the presence of multiple strains of the same species in the dataset , the resulting probabilities largely ignore the common ancestry of species with similar complements of proteins and should not be taken literally ; calculated " probabilities " are used only for comparison among different proteins from the same genome . These data are not suitable for inclusion in a sequence database , as they have been randomly permuted and no longer represent true biological sequences . For each variant , we plot against x the number of queries with P-value less than or equal to x. Initiation was defined as the start of an antipsychotic that was not prescribed during the previous 60 days or more . Using each profile-positive genome in turn , we scored every protein in that genome for its correlation between a phylogenetic profile and the list of related sequences in other genomes as measured by BLAST comparison . The following question was used to determine whether a person severely disabled due to mental health problems resided in the household : " Are there any members of your household who currently have mental problems that are so severe that the person has been unable to provide income or has been unable to help in the household for at least four weeks ? The analytical sample for the present study included treatment episodes of patients who were initiated at any time during the 3-year study or the 4 months prior to enrollment on any oral antipsychotic and had at least 1 year of follow-up in the study following initiation on the medication . To that end , we performed an additional sensitivity analysis in which the time from patient 's enrollment in US-SCAP to the time of patient 's initiation on the index medication was used as a covariate in the Cox Proportional Hazards regression model . The data are presented as percentage change in the fluorescence intensity at each time point ( F ) to the first time point ( F0 ) reading ; the term ( ( F - F0 ) / F0 ) 100 was used to represent this percentage change . This is indicated by the observation that the B group had significantly greater DHA concentration than the other groups , denoted in the table by " B > all " . We therefore asked whether we could detect H-Ras mutations in mammary tumors induced by an MMTV-Wnt1 transgene in a p53-null background ; a failure to find such mutations would imply either that p53 is somehow required for such mutations to occur or , more likely , that an inherited deficiency of p53 conferred a growth advantage to Wnt1-expressing mammary cells that would outweigh any selective advantage provided by a secondary somatic mutation in H-Ras . Our scheme takes into account the interaction between genes as well as that between genes and the tool and thus is able find a very small set and can discover novel genes . We showed that wound healing was delayed for 2 hours in mutant cells , but that once healing began , the cells moved as fast as wild-type . Figure 5 presents the probability of discontinuing the medication during the 1 year following initiation for each atypical antipsychotic compared to perphenazine , and Table 5 presents the hazard ratios ( HR ) and 95 % confidence intervals of time to all-cause medication discontinuation of each atypical agent versus perphenazine using the Cox Proportional Hazards regression model . Available patient characteristics at baseline – the time of initiation on the index drug – were fewer than characteristics assessed at the time of patients ' enrollment in the study , because the assessments were not set to coincide with time of initiation or discontinuation of any medication .