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This means that therapeutic failure occurs in many patients , perhaps in most of them , due either to a lack of strength - meaning two drugs - or a lack of adherence under schemes where protease inhibitors are used . Yet with most of the structural funds allocated to member states , regional policy has been an affirmation of national boundaries as much as a counter-force . Warren went to Montreal , far from most of his friends and the community he knew , depressed and increasingly desperate - - in the literal sense of " without hope " . The critical period for chemical control in problem orchards begins at the late swollen bud to green cluster stage , and continues until just before most of the blossoms are open . Yet in most of the city , where poor and working-class people live , there were few signs of the strike .