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Figure 5 presents the probability of discontinuing the medication during the 1 year following initiation for each atypical antipsychotic compared to perphenazine , and Table 5 presents the hazard ratios ( HR ) and 95 % confidence intervals of time to all-cause medication discontinuation of each atypical agent versus perphenazine using the Cox Proportional Hazards regression model . This contrasts sharply with the report by D'Cruz et al. [ 3 ] of mutations affecting mostly K-Ras and also N-Ras , but never H-Ras , in mouse mammary tumors induced by an MMTV-c-Myc transgene . This average is greater than we reported elsewhere for cortices of similar baboons [ 27 ] . We were unable to statistically address the small sample size problem and suggest , therefore , that the ziprasidone-related findings be interpreted with caution . Sampling fraction and sub-network size . In global gene-expression studies , such as the data presented here , NTERA-2 closely mimics hESC lines , showing an average r2 with the hESC pool of 0.84 for all genes and 0.88 for genes at high confidence . On average , patients were moderately and chronically ill with mild depressive symptoms , poor quality of life , and 20.7 years of illness duration . Another important difference between the experiments is the size of the wounds , which were very large ( 1000 – 1200 μ m ) in the study by Ramaesh et al [ 59 ] , encompassing up to half the cornea and encroaching on the limbal region . The last line shows the extrapolation from the present network to the true network size assuming random sampling . It has recently been suggested that ARK may be due to corneal epithelial fragility combined with an abnormal wound-healing response [ 12 ] , resulting in degeneration of the cornea . This pool shows great concordance of expression with individual normal hESC lines , as the correlation coefficients ( r2 ) with normal lines average 0.87 , or 0.93 for genes expressed at high confidence levels . On average , cases with psychotic symptoms had started to use khat earlier in life than matched controls and had been using khat 8.6 years before positive symptoms emerged . It is not clear whether the keratopathy is a direct result of reduced PAX6 gene dosage in the cornea itself , or due to recurrent corneal trauma secondary to defects such as dry eye caused by loss of PAX6 in other tissues . Table 5 presents the hazard ratios and 95 % confidence intervals for time to medication discontinuation of each atypical agent versus haloperidol with prophylactic anticholinergic agents , using the Cox Proportional Hazards regression model . From the boxplots it is apparent that with decreasing subnet size the clustering coefficient will tend to decrease , reflecting the increasingly sparse network with a correlated structure . There is ingrowth of blood vessels into the cornea , sporadic appearance of goblet cells [ 8,9 ] , and infiltration by inflammatory cells [ 10 ] . ( A ) The degree distribution for the full network and the average for the subnets ( averaged over the ensemble ) generated by sampling 80 % , 60 % , 40 % and 20 % of the nodes in the Saccharomyces cerevisiae protein interaction network . Table 5 presents the hazard ratios ( HR ) and 95 % confidence intervals of time to all-cause medication discontinuation of each atypical agent versus all the typicals using the Cox Proportional Hazards regression model . a Calculated via a t-test for age , size , and estrogen-receptor protein , via Fisher 's exact test otherwise .