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These cases were either de novo cases ( 2 patients ) of multiple sclerosis ( MS ) , exacerbation of pre-existing MS ( 4 patients ) , 2 cases each with encephalopathy or myelitis and two with optic neuritis and one with ischemic optic neuropathy . Around 1430 its quality was improved by caking it with alcohol or urine and grinding it into grains in ball mills . In a soil heavy with clay or sand and with little organic matter , plants may find it difficult to thrive . Most students do not , however , want meetings every week as this may cause scheduling problems with work or family and a feeling of overload .