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The use of this microarray method to distinguish undifferentiated and differentiated hESC cultures has been demonstrated [ 27 ] . The first cell row on the wound edge was not evaluated because it included damaged cells . Some researchers have claimed [ 8 ] that atypicals are of comparable efficacy to typical antipsychotics of medium or low potency , because lower-potency antipsychotics have a more favorable EPS profile , and thus provide greater tolerability and better outcomes . Despite the ongoing scientific debate about amphetamine-induced psychosis it remains unclear whether the use of amphetamine-like substances including khat may actually cause a psychotic disorder in an otherwise healthy individual , or trigger the onset of schizophrenia in an individual with high vulnerability to the disease [ 24,25 ] . This conclusion is based on our failure to find H-Ras mutations in any tumors arising in bitransgenic ( MMTV-Wnt1 / MMTV-Neu ) or p53-deficient ( MMTV-Wnt1 / p53 - / - ) mice ( Table 2 ) . Furthermore , the retrospective third-person assessment of the onset of psychotic signs , as well as the retrospective and subjective assessment of khat use , will have introduced some error variance in the data . Although the mismatch increases as the number of interactions in the gene control network increases , it stays within a limit of 2 in this particular example , showing the potential of our approach to discover the operating gene control network hidden in a larger one ( see Table 1 and 2 provided in the supplementary material ) . One advantage of this assay is that it also readily distinguishes male and female samples , and in theory can be used to examine relatedness between samples and the larger database sets that have been generated for other purposes . Moreover , to help the user identify the most representative EST probe in each dataset , i.e. the probe with the highest number of experiments , it also provides the number of valid data points for every probe . To facilitate comparisons among lines , the hESC research community has begun to develop a number of tools . In 2001 a change in phage type distribution in S. Enteritidis infections among Swedish travellers returning from some countries in southern Europe was observed , and a previously rare phage type ( PT 14b ) became one of the most commonly diagnosed that year , continuing into 2002 and 2003 . A second study limitation is the small sample size of the ziprasidone treatment group , which limited the statistical power of the analyses . The change in phage type distribution observed among Swedish travellers returning from some countries in Southern Europe in 2001 was not observed among inhabitants in the countries visited . However , unlike aspirin , some , but not all patients , treated chronically with naproxen maintain suppression of thromboxane throughout the whole dosing interval at a level compatible with effective platelet inhibition [ 10,11 ] . This concept has been applied successfully to identify critical functional residues for the CAAX prenyl protease [ 39 ] , a protein-sorting and modification enzyme useful for comparison because it , like EpsH , has multiple transmembrane segments . Consensus on the importance of continuous treatment with antipsychotics has been accompanied , however , by an ongoing debate over whether the newer " atypical " antipsychotics are superior to the older " typical " antipsychotics in the treatment of schizophrenia [ 8-13 ] . The majority of DHA studies have focused on its role in the cerebral cortex . Trained and annually certified examiners used this form to collect medication prescription information , which was used to identify an absence of a prescription for each index antipsychotic for more than 30 consecutive days . The fourth sensitivity analysis assessed the robustness of the medication gap used to signal medication discontinuation ( > 30 days ) by repeating the analyses with the more customary " longer-than-14-day " medication gap . Should experimental findings verify the proposed proteolytic activity , we believe members of the EpsH family should be called " exosortase " . The mechanisms underlying this failure have wide relevance for the understanding of the molecular basis of the wound-healing response . Results were essentially unchanged when the Cox Proportional Hazards regression model was repeated ( a ) using 1 medication episode per patient ( n = 1028 ) , the one with which the patient was treated first , ( b ) using 1703 treatment episodes , including episodes where patients simultaneously initiated 2 or more treatment episodes , ( c ) using the time elapsed between medication initiation and patients ' enrollment in the study , as a proxy for potential " sponsor-related physician bias , " ( d ) using a medication gap > 14 days to assess robustness of the > 30-day medication gap used to signal medication discontinuation , and ( e ) using ITT analysis , with 2488 treatment episodes , thus not requiring initiators to have continued in the study for at least 1 year following medication initiation . The third sensitivity analysis assessed " sponsor-related physician bias " by including the new covariate just described : the time elapsed between medication initiation and the patient 's enrollment date in the study .