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To deal with inheritance and subtpying , a formal set of rules for state machine and algebra refinement have been established , in order to determine when one specification is a subtype of another ( that is , considering the total behaviour of an object , not just looking at its type signatures ) . Exemestane is 90 % bound to plasma proteins and the fraction bound is independent of the total concentration . The total settlement could reach $ 500 million , the Mississippi attorney general said last week . Similarly , when the salinities of saltwater and blood increase , cells increase their levels of free amino acids so that the total concentration of dissolved molecules within the cells increases . " " In an effort to distribute funding to as many hams as possible , expense reimbursement will be $ 25 per day for a maximum of four days for a total reimbursement per radio amateur of $ 100 , " Hobart said . As a measure of the influence of the work of IMO the total ship loss rate has been reduced significantly since IMO met for the first time in 1959 and the amount of pollution caused by ships has been estimated to have been cut by 60 % in the last twenty years .