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The responsibility for the human subject must always rest with a medically qualified person and never rest on the subject of the research , even though the subject has given his or her consent . Click here ( PDF , German , 1.6MB ) for a leaflet on the subject . No little Gradgrind had ever known wonder on the subject , each little Gradgrind having at five years old dissected the Great Bear like a Professor Owen , and driven Charles 's Wain like a locomotive engine-driver . In seconds it had completely alleviated my concern on the subject .