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The best known is http://www.linuxrouter.org . He kept a painstaking record of his journey to California on one of the least known of the overland routes , crossing northern Mexico on the wild , little-used trail through Chihuahua and across the deserts of southern Arizona . You are invited to form the sole happiness of one of the most known men of the age , of one whose principles , whose temper , whose thoughts , you have been long acquainted with , and will , I believe , confess their universal constancy . The best known Gorgon , Medusa , was killed by the hero Perseus . Diamond , in addition to other advantageous properties , is the hardest known material , has the highest thermal conductivity of any other substance and is transparent to a wide variety of electromagnetic radiation . Perhaps the best known ( and frequently rated in the top 5 nightclubs in the United States ) is Toad 's Place . The most known disease of the cell cycle is the cancer , when some defect of the regulatory network cause uncontrolled cell proliferation . While , the hash-based signature may be the least known of the signature algorithms , it is rapidly becoming popular because it is less computationally intensive than the other algorithms . Two instantiations of our boosting technique have yield better compression algorithms than some of the best known ones , i.e ., LZ77 , LZ78 , PPMC and the ones derived from the BWT . This breakthrough has started to be applied to either an improved analysis of the mechanisms of defence taking place at intra-hepatic level and an analysis of the transcriptome of the liver-stages , the least known of the whole malaria cycle . The Rhesus Macaque often called the Rhesus Monkey , is one of the best known species of Old World monkeys .