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The research projects ongoing in his laboratory can be summarized as follows : 1 ) characterization of the structure of the IFN receptor and the interaction with kinases of the JAK family which are responsible for the activation of the system ; 2 ) characterization of interaction of the beta Long subunit of the IFN alpha receptor with transcription factors Stat 1 and 2 . As macromolecular recognition processes are thought to be based on the complementarity of molecular shapes and charge distributions ( 35 ) , conservation of active site regions , that allows to identify genomic sequences as kinases of certain type may correspond to the conservation of substrate specificity . Moreover , the outcome of AICAR on proliferation and survival was dependent on p53 activation and the presence of LKB1 , the major upstream kinases of AMPK . These in turn control the activation of Ser / Thr kinases of the protein kinase C family . We have recently identified a number of putative regulatory genes , including cyclin-dependent kinases of Toxoplasma .