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Given the importance of PPIs , we suggest that submission of PPIs to repositories be made mandatory by scientific journals at the time of manuscript submission as this will minimize annotation errors , promote standardization and help keep the information up to date . The position of the six RNA polymerase intein insertion sites mapped onto the crystal structure of the RNA polymerase II of Saccharomyces cerevisiae . In tumors induced by components of the Wnt signaling pathway , a high proportion of cells produce proteins ( Sca-1 , Keratin 6 ) associated with early stages of mammary development , whereas few such cells are observed in tumors induced by activators of Ras signaling [ 9 ] . Genes ( closed boxes ) shown on the outside of the map are transcribed in a clockwise direction , whereas those on the inside of the map are transcribed counterclockwise . Some researchers have claimed [ 8 ] that atypicals are of comparable efficacy to typical antipsychotics of medium or low potency , because lower-potency antipsychotics have a more favorable EPS profile , and thus provide greater tolerability and better outcomes . Use of treatment episode as the unit of analysis may create bias , because 1 patient may have been initiated on several medications over time , thus contributing multiple episodes . Whereas the information given by examined cases could be validated by the information of family members , we were well aware of the danger that the matched controls might have under-reported their khat intake . The first term ( see below ) of the summation over all possible YES counts from y up to N dominates when YES genomes are relatively rare , but the full summation is performed . These findings were driven primarily by clozapine and olanzapine , as treatment with risperidone did not differ from perphenazine on 2 of the 3 statistical methods , whereas treatment with quetiapine or ziprasidone did not significantly differ from perphenazine on any of the 3 statistical methods . The lack of comparative analysis of hESC lines matters , because the properties and behavior of each line are uniquely shaped by their histories . The region illustrated in each uppercase panel below is indicated by the dashed box , and in each lowercase panel by the red box . Calcium signaling occurs in the first 2 minutes , whereas ERK1 / 2 signaling is expected to peak about 3 – 10 minutes after wounding [ 34 ] . Available patient characteristics at baseline – the time of initiation on the index drug – were fewer than characteristics assessed at the time of patients ' enrollment in the study , because the assessments were not set to coincide with time of initiation or discontinuation of any medication . Some have reported comparable efficacy [ 12 ] and questioned the claims of superior efficacy of atypicals relative to typicals [ 8,12,13 ] because clinical trials have often established efficacy of the atypicals in comparison to haloperidol , a high-potency typical antipsychotic known to have pronounced treatment-emergent extrapyramidal symptoms ( EPS ) that may contribute to poorer treatment outcomes .