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Furthermore , antipsychotic switching processes are often characterized by medication overlap with cross-titration , which amounts to short-term ( and at times prolonged ) antipsychotic polypharmacy , thus making true monotherapy treatment episodes relatively rare and possibly not representative of the complex treatment regimens in real-world practice . The authors found the first - and second-generation antipsychotics to be highly heterogeneous groups with regard to effectiveness in a real-world setting , and reported that patients treated with clozapine or olanzapine had substantially lower discontinuation rates of their initial treatment than patients treated with haloperidol . Radioactive images were analyzed and quantitated by a phosphoimager . Human embryonic stem cells ( hESC ) offer a renewable source of a wide range of cell types for use in research and cell-based therapies to treat disease . Wounded cells phosphorylated the extracellular signal-related kinases 1/2 ( phospho-ERK1 / 2 ) . Due to scarce numbers of chronic users for other individual NSAIDs , we could not estimate their respective duration-response relationship .