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Unlike ANA , antithyroid antibodies are independent markers for an increased risk of miscarriage . However , the presence of antithyroid antibodies ( to thyroid antigens thyroglobulin and thyroid peroxidase ) may represent a generalized autoimmune abnormality rather than a specific thyroid dysfunction . Pt is hypothyroid and does have antithyroid antibodies . They are derived from the conventional antibodies within the Camelidae lineage , and are apparently the outcome of more recent adaptive changes occurring in the compartment of heteromeric antibodies . The importance of TNF in particular is demonstrated by studies showing the protective effects of anti-TNF antibodies in various animal models of human diseases ( e.g . In fact , the ability to detect HIV-specific antibodies has led to the production of commercial , easy-to-use saliva test kits . While it would be preferable to measure directly these anti-toxic antibodies , this is not currently possible .