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The fold changes are shown on the log2 scale , so the dashed line at zero corresponds to no differential expression , positive values correspond to up-regulation in treated cells , and negative values correspond to down-regulation in treated cells compared with untreated control cells ( see additional file 1 on fold change calculation and gene matching ) . Remarkably , not all the 5 studied atypicals differentiated significantly and consistently from typicals of various potency levels , as findings were primarily driven by clozapine and olanzapine , and to a lesser extent by risperidone . Included in Figure 2 is a scale showing DHA values ranked from highest to lowest and statistical differences . Patients are labeled according to HRT use , recurrence-free survival ( = recurrence , defined as distant metastases or death within 5 years of diagnosis ) , Elston grade 3 , lymph node status , and ER level measured on the protein level . We hypothesized that if " sponsor-related physician bias " were present , physicians would have quickly switched patients from their current antipsychotic to olanzapine rather than to risperidone ( olanzapine , risperidone , and clozapine were available for all patients at the time of enrollment , unlike quetiapine and ziprasidone that were not yet available to early study enrollees ) . In both studies , treatment with olanzapine , but not with risperidone , quetiapine , or ziprasidone , was associated with significantly longer time to all-cause medication discontinuation when compared with perphenazine . These findings were driven primarily by clozapine , olanzapine , and risperidone , as quetiapine did not consistently differ from haloperidol with prophylactic anticholinergics , and treatment with ziprasidone did not significantly differ from haloperidol with prophylactic anticholinergics on any of the 3 statistical approaches . Each column corresponds to a patient labeled according to survival ( = recurrence ; defined as distant metastases or death within 5 years of diagnosis ) , Elston grade 3 , and lymph node status , where gray symbols indicate missing values . In Parkinson 's disease , elimination of excessive output of the inner segment of the globus pallidus by surgical removal or lesion of the subthalamic nucleus has re-emerged as a treatment for elimination of tremors [ 16 ] . Others also reported [ 12 ] that olanzapine is not more efficacious than haloperidol when haloperidol is provided with prophylactic anticholinergic treatment to help ameliorate EPS . Representative scale bar in ( e ) ( for the second panel in each pair ) is 200 μ m. All animals possessed shells of between 5 and 6 mm ( anterior-posterior ) .