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The Global Positioning System ( GPS ) provides this precise common time reference . When you lose a friend , you lose yourself ( William Worden ) . " She also regrets that Coppola turned down her offer ( made through fashion designer Marc Jacobs ) of serving as an advisor on the film , as she did n't want any " stuffy professors " involved . Mild elevations in the levels of these substances and in urinary aminolevulinic acid ( ALA ) also occur , but porphobilinogen ( PPG ) levels are in the reference range . Steve Frank ( UC Irvine ) introduced a multilocus model of gene-for-gene interactions which included both costs of resistance and virulence .