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This method of reducing the code size is simple and inexpensive , and it required no changes to compilers , assemblers , or linkers . The above simple sampling procedure would work fine if the group size was static . The sample code size is not necessarily representative and there are several errors due to the automated and vast nature of the task of identifying and crediting authors . However , no study considered individually could be regarded as conclusive : the sample sizes were too small , and there were in some cases unanticipated increases in non-cardiovascular deaths , although these were not statistically significant . The volume of vaccine , patient age , and muscle size are also important determinants . First , spending by school district size is higher only for those school districts with under 1,000 enrollment , other factors being equal .