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We look for active oversight of risk parameters by senior management ; we look at internal audit and funding , liquidity and credit controls . The Carter Center , with support from Lions Clubs International and the Conrad N. Hilton Foundation , has been fighting trachoma in Africa since 1998 through implementation of the SAFE Strategy : Surgery to reverse in-turned lashes due to scarring from frequent trachoma infections ; Antibiotic treatment for active trachoma infections ; Facial cleanliness ; and Environmental improvement to reduce the number of trachoma-spreading flies in endemic communities . We have employed modeling and electrostatically accurate solution molecular dynamics to build complete molecular models for active enzymes in the cascade . As part of this effort , we are interested if the physical presence of certain general transcription factors , co-activators or proteasome constituents could serve as sensitive physical markers for active genes and also define their boundaries . All close contacts — especially young children — must be evaluated for TB so they may be treated promptly for active disease or given prophylaxis as indicated .