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Despite the ongoing scientific debate about amphetamine-induced psychosis it remains unclear whether the use of amphetamine-like substances including khat may actually cause a psychotic disorder in an otherwise healthy individual , or trigger the onset of schizophrenia in an individual with high vulnerability to the disease [ 24,25 ] . Furthermore , the retrospective third-person assessment of the onset of psychotic signs , as well as the retrospective and subjective assessment of khat use , will have introduced some error variance in the data . As described above , in the whole-eye culture system , the corneal epithelial migration is modulated by the presence of an inflamed stroma , which would be expected to accelerate cell migration over extended periods of healing . Some have reported comparable efficacy [ 12 ] and questioned the claims of superior efficacy of atypicals relative to typicals [ 8,12,13 ] because clinical trials have often established efficacy of the atypicals in comparison to haloperidol , a high-potency typical antipsychotic known to have pronounced treatment-emergent extrapyramidal symptoms ( EPS ) that may contribute to poorer treatment outcomes . No explanation for the sudden increase in this phage type among Nordic travellers to different countries in Southern Europe has been found . All bootstrap values > 50 have been reported except in cases where allelic inteins fall within a well-supported ( 95 – 100 % bootstrap ) group , when some values > 50 have been omitted for reasons of space . This expands the utility of SNPs to detect non-reciprocal translocations , aneuploidy , and partial amplifications or deletions of chromosomes . A medication gap could have resulted from any number of events , including switching to another antipsychotic or discontinuation of the antipsychotic drug . It identifies one or two members in every genome marked YES in the original profile and none in all genomes marked NO . In addition , with bitransgenic mice , we could ask whether a co-existing MMTV-Wnt1 transgene eliminated the selective advantage conferred by an activating mutation in the coding domain of the MMTV-Neu transgene , and we could ask whether the phenotype of tumor cells in resulting tumors resembled the phenotype of tumors induced by components of the Wnt pathway , the Neu / Ras pathway , or both . Content validity was assured by the involvement of clinical experts at all levels of the translation process . Clinical interviews were carried out by some of the authors ( MO , MS , CC , BL ) , all trained in the assessment of psychotic disorders and PANSS rating . This is indicated by the observation that the B group had significantly greater DHA concentration than the other groups , denoted in the table by " B > all " . Spain reported an outbreak of the same phage in a school in January ( unpublished data ) . This measure assessed the number of consecutive days from initiation of the index antipsychotic to the start of the first medication gap larger than 30 consecutive days during the first year following initiation . Consensus on the importance of continuous treatment with antipsychotics has been accompanied , however , by an ongoing debate over whether the newer " atypical " antipsychotics are superior to the older " typical " antipsychotics in the treatment of schizophrenia [ 8-13 ] . To further assess the robustness of the findings , sensitivity analyses were performed , including the use of ( a ) only 1 medication episode for each patient , the one with which the patient was treated first , and ( b ) all medication episodes , including those simultaneously initiated on more than 1 antipsychotic . The match of any one protein from the reference genome to the phylogenetic profile becomes optimized for that protein by automatic selection of the most favorable BLAST E-value cutoff . This conclusion is based on our failure to find H-Ras mutations in any tumors arising in bitransgenic ( MMTV-Wnt1 / MMTV-Neu ) or p53-deficient ( MMTV-Wnt1 / p53 - / - ) mice ( Table 2 ) . A potential small protective effect associated with naproxen has been reported in most epidemiological studies [ 6 ] , but not all [ 9 ] . The analytical sample for the present study included treatment episodes of patients who were initiated at any time during the 3-year study or the 4 months prior to enrollment on any oral antipsychotic and had at least 1 year of follow-up in the study following initiation on the medication . The extensive use of this technology by hundreds laboratories has resulted in the production of an enormous amount of data , many of which have been deposited in public databases [ 5,6 ] . Some of these assays have been previously performed on individual lines , but to our knowledge , no single group has used all of these tests on any single line , and few comparisons between lines have been made publicly available . To address this point , we analyzed the ability of the three methods to predict known physical and functional interactions among mammalian proteins . Figure 1 illustrates the treatment-episodes approach , and the potential for overlap between treatment episodes for any given patient during the 3-year study .