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Similar questions are addressed in studies that show how anti-predator behaviors are lost in wild populations of prey animals in places where large predators have been extirpated ( Berger 1997 ) . Obviously Sheffield was talking about the period being audited and Larsen 's reply ( which he admitted making ) must have referred to that period . No. 1016 ( 1989 ) , for the statement that the two-year time limit begins on the date an expenditure was made , which is " the quarter in which any State agency made a payment to any individual facility or entity furnishing Title XIX services under a provider agreement with the Medicaid agency . au lait macules ( CALMs ) , polyostotic fibrous dysplasia ( PFD ) , and endocrine dysfunction with precocious puberty.Pathophysiology : The most widely accepted hypothesis is that a spontaneous mutation in early embryogenesis leads to a mosaic pattern of autonomously functioning clones of cells in the affected child 's organs ( eg , ovarian cysts ) .