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First of all , a therapy for a symptom or sign that can be tied to a structural or functional abnormality of the body is therapy flat out . Patients may become akinetic and rigid in the terminal stages of the illness.Dystonia is defined as a syndrome of sustained muscle contractions , frequently causing twisting and repetitive movements or abnormal postures.Mild dystonia , in combination with chorea , may give the writhing appearance of choreoathetosis.Sustained dystonic posturing may result in contractures , immobility , and breakdown of skin.Dystonia may be prominent in juvenile HD.Eye movement abnormalities can be seen early in the disease.Initiation of saccadic movements is slow and uncoordinated . In some cases , the elevated blood pressure is due to narrowing of the aorta or a kidney abnormality . For example , abnormalities may develop from poor posture due to loss of muscle strength in the lower extremities or overuse of upper extremities in those who are wheelchair-bound . Laboratory abnormalities were uncommon , with an elevation in liver function tests being the most common abnormality . Abnormality . AB - PURPOSE : We characterize the genetic abnormalities associated with pathological subtypes of renal tumors , which may help diagnosis or prognostication . Ventral midline dysplasia , characterized by optic atrophy , and eye abnormalities have been observed . Assess for musculoskeletal abnormalities in the diabetic foot , such as limited joint mobility , prominent metatarsal heads , and Charcot 's deformities . In 1 prospective investigation of 128 patients admitted because of acute stroke , a swallowing abnormality was detected in 51 % on clinical examination and in 64 % on videofluoroscopy at initial presentation .