tokens: Several mutations disrupted the endonuclease and helicase activities ; however , only one amino-terminal-charge cluster mutant protein ( D40A-D42A-D44A ) completely lost AAV hairpin DNA binding activity .
folded_tokens: several mutation disrupt the endonuclease and helicase activity ; however , only one amino-terminal-charge cluster mutant protein ( d40a-d42a-d44a ) completely lose AAV hairpin dna binding activity .