tokens: We previously showed that this proteolysis 1 ) can be acutely promoted by the phorbol ester phorbol 12-myristate 13-acetate ( PMA ) , 2 ) requires a metalloprotease activity , 3 ) generates both shed GHBP and a membrane associated GHR transmembrane / cytoplasmic domain remnant , and 4 ) results in down-regulation of GHR abundance and GH signaling .
folded_tokens: we previously show that this proteolysis 1 ) can be acutely promote by the phorbol ester phorbol 12-myristate 13-acetate ( pma ) , 2 ) require a metalloprotease activity , 3 ) generate both shed ghbp and a membrane associate ghr transmembrane / cytoplasmic domain remnant , and 4 ) result in down-regulation of ghr abundance and gh signaling .