tokens: Studying intracellular signaling pathways , which may be involved in malignant transformation of Ret-9bp expressing NIH3T3 cells , we could demonstrate Ret-9bp dependent phosphorylation of insulin receptor substrate-2 ( IRS-2 ) with consecutive activation of phosphatidylinositol 3-kinase ( PI 3-kinase ) and protein kinase B ( PKB / AKT ) .
folded_tokens: study intracellular signaling pathway , which may be involve in malignant transformation of ret-9bp express nih3t3 cell , we could demonstrate ret-9bp dependent phosphorylation of insulin receptor substrate-2 ( irs-2 ) with consecutive activation of phosphatidylinositol 3-kinase ( pi 3-kinase ) and protein kinase b ( pkb / AKT ) .