tokens: Down-regulation of IRS-1 is linked to its serine phosphorylation dependent on PI 3-kinase activity and appears required for differentiation to occur , as IRS-1 is not modified and continues to accumulate in a nondifferentiating myoblast cell line .
folded_tokens: down-regulation of irs-1 be link to its serine phosphorylation dependent on pi 3-kinase activity and appear require for differentiation to occur , as irs-1 be not modify and continue to accumulate in a nondifferentiating myoblast cell line .