tokens: Thus , these studies on rat Std promoter function indicate that ( i ) HNF1 and C / EBP are responsible for liver specificity of the rat Std gene ; ( ii ) androgenic repression of the gene requires the presence of all of the OCT-1 and C / EBP elements between positions -231 and -292 ; and ( iii ) AR may exert its negative regulatory effect indirectly through transcriptional interference of OCT-1 and C / EBP rather than through a direct DNA-AR interaction .
folded_tokens: thus , these study on rat std promoter function indicate that ( i ) hnf1 and c / ebp be responsible for liver specificity of the rat std gene ; ( ii ) androgenic repression of the gene require the presence of all of the oct-1 and c / ebp element between position -231 and -292 ; and ( iii ) ar may exert its negative regulatory effect indirectly through transcriptional interference of oct-1 and c / ebp rather than through a direct dna-ar interaction .