tokens: TPO by itself did not activate ERK1 , ERK2 and protein kinase C ( PKC ) , whereas TPO directly enhanced the PKC dependent activation of ERKs induced by other agonists including thrombin and phorbol esters , without affecting the PKC activation by those agonists .
folded_tokens: tpo by itself do not activate erk1 , erk2 and protein kinase c ( pkc ) , whereas tpo directly enhance the pkc dependent activation of erk induce by other agonist include thrombin and phorbol ester , without affect the pkc activation by those agonist .