tokens: In addition , and in support of a mediating role of STATs in the activation of the p21 promoter , overexpression of Stat3 potentiated the cytokine effect on the p21 promoter ; whereas a dominant negative Stat3 , or a mutation of the STAT response element on the promoter , significantly reduced the cytokine effect .
folded_tokens: in addition , and in support of a mediate role of stats in the activation of the p21 promoter , overexpression of stat3 potentiate the cytokine effect on the p21 promoter ; whereas a dominant negative stat3 , or a mutation of the stat response element on the promoter , significantly reduce the cytokine effect .