tokens: Ligand binding to the receptor complex leads to tyrosine phosphorylation and activation of Janus kinases ( Jak ) , phosphorylation of the signal transducing subunit gp130 , followed by recruitment and phosphorylation of the signal transducer and activator of transcription factors STAT3 and STAT1 and the src homology domain ( SH2 ) - containing protein tyrosine phosphatase ( SHP2 ) .
folded_tokens: ligand binding to the receptor complex lead to tyrosine phosphorylation and activation of janus kinase ( jak ) , phosphorylation of the signal transducing subunit gp130 , follow by recruitment and phosphorylation of the signal transducer and activator of transcription factor stat3 and stat1 and the src homology domain ( sh2 ) - contain protein tyrosine phosphatase ( shp2 ) .