tokens: However , mutations in the HNF-4 binding site on element CIIB and inhibition of HNF-4 synthesis in HepG2 cells by antisense HNF-4 constructs decreased the apoCII promoter activity to 25-40 % of the control , indicating that HNF-4 is a positive regulator of the apoCII gene .
folded_tokens: however , mutation in the hnf-4 binding site on element ciib and inhibition of hnf-4 synthesis in hepg2 cell by antisense hnf-4 construct decrease the apocius promoter activity to 25-40 % of the control , indicate that hnf-4 be a positive regulator of the apocius gene .