tokens: Although linker regions in transcription factors are known to modulate DNA binding specificity , our studies suggest that the human HSF1 linker plays no role in determining HSF1 binding preferences in vivo but is a critical determinant in regulating the HSF1 monomer-trimer equilibrium .
folded_tokens: although linker region in transcription factor be know to modulate dna binding specificity , we study suggest that the human hsf1 linker play no role in determine hsf1 binding preference in vivo but be a critical determinant in regulate the hsf1 monomer-trimer equilibrium .