tokens: A proportion of APC wild-type colon carcinomas and melanomas also contains constitutive nuclear Tcf-4 / beta-catenin complexes as a result of dominant mutations in the N terminus of beta-catenin that render it insensitive to downregulation by APC , GSK3 beta , and Axin / Conductin .
folded_tokens: a proportion of apc wild-type colon carcinoma and melanoma also contain constitutive nuclear tcf-4 / beta-catenin complex as a result of dominant mutation in the n terminus of beta-catenin that render it insensitive to downregulation by apc , gsk3 beta , and axin / Conductin .