tokens: By negatively regulating GRK mediated receptor phosphorylation , beta-arrestin mediated processes such as Src recruitment and clathrin mediated internalization , which are required for GPCR mediated ERK activation , are inhibited , thus dampening further ERK activation .
folded_tokens: by negatively regulate grk mediated receptor phosphorylation , beta-arrestin mediate process such as src recruitment and clathrin mediate internalization , which be require for gpcr mediate erk activation , be inhibit , thus dampen further erk activation .