tokens: Significantly , two proximal GATA-1 binding sites ( -118 / -113 and -98 / -93 ) and a region located within -518 to -315 bp of the mouse ALAS2 promoter were essential for transcriptional activation during chemically induced differentiation of MEL cells , implying their importance in conferring erythroid specificity to the ALAS2 transcriptional activation .
folded_tokens: significantly , two proximal gata-1 binding site ( -118 / -113 and -98 / -93 ) and a region located within -518 to -315 bp of the mouse alas2 promoter be essential for transcriptional activation during chemically induce differentiation of mel cell , imply they importance in confer erythroid specificity to the alas2 transcriptional activation .