tokens: Herein , we show that Smad3 physically interacts with the HMG box domain of LEF1 and that TGFbeta and Wnt pathways synergize to activate transcription of the Xenopus homeobox gene twin ( Xtwn ) .
folded_tokens: herein , we show that smad3 physically interact with the hmg box domain of lef1 and that tgfbeta and wnt pathway synergize to activate transcription of the xenopus homeobox gene twin ( xtwn ) .