tokens: By progressive 5 ' - deletion studies , we have identified a 248-bp DNA fragment ( -1018 to -771 , relative to the translation start site ) at the 5 ' - flanking region of the human GnRHR gene that is responsible for the GnRHa mediated down-regulation of human GnRHR promoter activity .
folded_tokens: by progressive 5 ' - deletion study , we have identify a 248-bp dna fragment ( -1018 to -771 , relative to the translation start site ) at the 5 ' - flanking region of the human gnrhr gene that be responsible for the gnrha mediate down-regulation of human gnrhr promoter activity .