tokens: MEKs and ERKs inhibited IL-6 activation of Stat3 harboring a mutation at serine-727 , the major site for serine phosphorylation , similar to inhibition of wild-type Stat3 , and inhibited Janus kinases Jak1 and Jak2 upstream of Stat3 in the Jak-STAT signaling pathway .
folded_tokens: mek and erk inhibit il-6 activation of stat3 harbor a mutation at serine-727 , the major site for serine phosphorylation , similar to inhibition of wild-type stat3 , and inhibit janus kinase jak1 and jak2 upstream of stat3 in the jak-stat signaling pathway .