tokens: Mutagenesis of the CDE / CHR elements and Sp1 sites in this region , alone or in combination , reduced transcriptional activity by 40-60 % in asynchronously growing cells and abolished cell cycle periodicity in G2-M synchronized cells .
folded_tokens: mutagenesis of the cde / chr element and sp1 site in this region , alone or in combination , reduce transcriptional activity by 40-60 % in asynchronously grow cell and abolish cell cycle periodicity in g2-m synchronize cell .