tokens: Here we demonstrate that the mechanism of activation of HIF-1alpha is a multi-step process which includes hypoxia dependent nuclear import and activation ( derepression ) of the transactivation domain , resulting in recruitment of the CREB binding protein ( CBP ) / p300 coactivator .
folded_tokens: here we demonstrate that the mechanism of activation of hif-1alpha be a multi-step process which include hypoxium dependent nuclear import and activation ( derepression ) of the transactivation domain , result in recruitment of the creb binding protein ( cbp ) / p300 coactivator .