tokens: The immune system is closely integrated with the neuroendocrine system , and infection induced increases in cytokines such as IL-1 , IL-6 and TNF have numerous effects on the central nervous system .
folded_tokens: the immune system be closely integrate with the neuroendocrine system , and infection induce increase in cytokine such as il-1 , il-6 and tnf have numerous effect on the central nervous system .