tokens: In an attempt to reduce the incidence of NSAID induced gastrointestinal lesions , the following approaches have been proposed : ( i ) use of the prostaglandin analogue misoprostol , which is an antiulcer drug which has been proven to be as effective in the prevention of NSAID induced gastric and duodenal ulcers as in the reduction of serious upper gastrointestinal complications ; ( ii ) histamine H2 receptor antagonists ( H2 antagonists ) , e.g. ranitidine , cimetidine and famotidine , which are useful in the prevention of NSAID induced duodenal ulcers during long term treatment , but not in the prevention of NSAID induced gastric ulcers ; ( iii ) proton pump inhibitors , e.g omeprazole , and pantoprazole , whose efficacy in preventing NSAID associated ulcers has been recently demonstrated ; and ( iv ) barrier agents , e.g. sucralfate , which can not be recommended as prophylactic agents to prevent NSAID induced gastropathy .
folded_tokens: in a attempt to reduce the incidence of nsaid induce gastrointestinal lesion , the follow approach have be propose : ( i ) use of the prostaglandin analogue misoprostol , which be a antiulcer drug which have be prove to be as effective in the prevention of nsaid induce gastric and duodenal ulcer as in the reduction of serious upper gastrointestinal complication ; ( ii ) histamine h2 receptor antagonist ( h2 antagonist ) , e.g. ranitidine , cimetidine and famotidine , which be useful in the prevention of nsaid induce duodenal ulcer during long term treatment , but not in the prevention of nsaid induce gastric ulcer ; ( iii ) proton pump inhibitor , e.g omeprazole , and pantoprazole , whose efficacy in prevent nsaid associate ulcer have be recently demonstrate ; and ( iv ) barrier agent , e.g. sucralfate , which can not be recommend as prophylactic agent to prevent nsaid induce gastropathy .