tokens: This effect required ( i ) IR activation since it was abrogated by IR mutation at tyrosines 1162 and 1163 and ( ii ) NF-kappaB activation since it was abolished by overexpression of dominant negative IkappaB-alpha ( A32 / 36 ) and mimicked by overexpression of the NF-kappaB c-Rel subunit .
folded_tokens: this effect require ( i ) ir activation since it be abrogate by ir mutation at tyrosine 1162 and 1163 and ( ii ) nf-kappab activation since it be abolish by overexpression of dominant negative ikappab-alpha ( a32 / 36 ) and mimic by overexpression of the nf-kappab c-rel subunit .