tokens: Based on this analysis , we propose that the interactions of Sos with the switch 1 and switch 2 regions of Ras have distinct functional consequences : the interaction with switch 2 mediates the anchoring of Ras to Sos , whereas the interaction with switch 1 leads to disruption of the nucleotide binding site and GDP dissociation .
folded_tokens: base on this analysis , we propose that the interaction of so with the switch 1 and switch 2 region of ra have distinct functional consequence : the interaction with switch 2 mediate the anchoring of ra to Sos , whereas the interaction with switch 1 lead to disruption of the nucleotide binding site and gdp dissociation .