tokens: D5 / D1 ( CT ) or D5 / D1D ( CT ) tail substitution mutants displayed a rank order of potency and agonist affinities virtually mimicking wild-type ( wt ) D1 receptors , as indexed by both ligand binding and dopamine stimulated cAMP accumulation assays , and , similar to wt D1 receptors , did not exhibit receptor constitutive activity or responsiveness to inverse agonists .
folded_tokens: d5 / d1 ( ct ) or d5 / d1d ( ct ) tail substitution mutant display a rank order of potency and agonist affinity virtually mimic wild-type ( wt ) d1 receptor , as index by both ligand binding and dopamine stimulate camp accumulation assay , and , similar to wt d1 receptor , do not exhibit receptor constitutive activity or responsiveness to inverse agonist .