tokens: At physiological doses , either insulin like growth factor I ( IGF-I ) or insulin turned out to be as potent as dibutyryl cAMP ( dbcAMP ) in increasing UCP1 gene transcription rate ( 1 h ) and also UCP1 mRNA accumulation ( 3 h ) , their maximal effect ( 15-fold increase ) reached upon treatment for 24 h.
folded_tokens: at physiological dose , either insulin like growth factor I ( igf-i ) or insulin turn out to be as potent as dibutyryl camp ( dbcamp ) in increase ucp1 gene transcription rate ( 1 h ) and also ucp1 mrna accumulation ( 3 h ) , they maximal effect ( 15-fold increase ) reach upon treatment for 24 h.