tokens: The coordinate increase in cyclin D1 and p21 had the effect of decreasing the specific but not absolute activity of cyclin D1 / cdk4 . p53 was not involved since CSF-1 induction of p21 was unaffected by dominant negative p53 expression .
folded_tokens: the coordinate increase in cyclin d1 and p21 have the effect of decrease the specific but not absolute activity of cyclin d1 / cdk4 . p53 be not involve since csf-1 induction of p21 be unaffected by dominant negative p53 expression .