Hence , Ca2+ binds to calmodulin , leading to the binding of calmodulin to calcineurin ; the activated calcineurin , in turn , may dephosphorylate the cytoplasmic subunit of NF-AT , resulting in its translocation from the cytoplasm into the nucleus to form a competent transcriptional activator .
hence , ca2+ binds to calmodulin , leading to the binding of calmodulin to calcineurin ; the activated calcineurin , in turn , may dephosphorylate the cytoplasmic subunit of nf-at , resulting in its translocation from the cytoplasm into the nucleus to form a competent transcriptional activator .
O O B-atom O O B-protein_molecule O O O O O O B-protein_molecule O B-protein_molecule O O O B-protein_molecule O O O O O O O B-protein_subunit I-protein_subunit I-protein_subunit B-protein_molecule O O O O O O O O O O B-cell_component O O O B-protein_family_or_group I-protein_family_or_group I-protein_family_or_group O