When a therapy proves effective , do clinicians truly know how it works? Even with a therapy as specific as anti-TNF antibody , it is not clear if the benefit is attributable to simple binding and clearance of TNF-alpha or to binding on the cell surface and subsequent deletion of the activated macrophage .
when a therapy proves effective , do clinicians truly know how it works? even with a therapy as specific as anti-tnf antibody , it is not clear if the benefit is attributable to simple binding and clearance of tnf-alpha or to binding on the cell surface and subsequent deletion of the activated macrophage .
O O O O O O O O O O O O O O O O O O O O B-protein_family_or_group I-protein_family_or_group O O O O O O O O O O O O O O O O B-protein_molecule O O O O O B-cell_component I-cell_component O O O O O B-cell_type I-cell_type O