To investigate in vivo regulatory mechanisms that control the population of type 2 T cells and disease susceptibility , we have created lines of transgenic mice in which expression of a chimeric cytokine receptor ( the mouse interleukin 2 receptor beta chain [ IL-2Rbeta ] extracellular domain fused to the cytoplasmic tail of IL-4Ralpha ) is targeted to the T lymphoid lineage using the proximal lck promoter .
to investigate in vivo regulatory mechanisms that control the population of type 2 t cells and disease susceptibility , we have created lines of transgenic mice in which expression of a chimeric cytokine receptor ( the mouse interleukin 2 receptor beta chain [ il-2rbeta ] extracellular domain fused to the cytoplasmic tail of il-4ralpha ) is targeted to the t lymphoid lineage using the proximal lck promoter .
O O O O O O O O O O O B-cell_type I-cell_type I-cell_type I-cell_type O O O O O O O O O B-multi_cell I-multi_cell O O O O O B-protein_family_or_group I-protein_family_or_group I-protein_family_or_group O O B-protein_subunit B-protein_subunit I-protein_subunit I-protein_subunit I-protein_subunit I-protein_subunit O B-protein_subunit O O O O O O B-protein_domain_or_region I-protein_domain_or_region O B-protein_molecule O O O O O B-cell_type I-cell_type I-cell_type O O B-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region O