By contrast , AM580 is not effective as ATRA in modulating the expression of these differentiation markers in the HL-60 cell line and in freshly isolated granulocytes obtained from the peripheral blood of chronic myelogenous leukemia patients during the stable phase of the disease .
by contrast , am580 is not effective as atra in modulating the expression of these differentiation markers in the hl-60 cell line and in freshly isolated granulocytes obtained from the peripheral blood of chronic myelogenous leukemia patients during the stable phase of the disease .
O O O B-other_organic_compound O O O O B-other_organic_compound O O O O O O B-protein_family_or_group I-protein_family_or_group O O B-cell_line I-cell_line I-cell_line O O B-cell_type I-cell_type I-cell_type O O O B-tissue I-tissue O B-multi_cell I-multi_cell I-multi_cell I-multi_cell O O O O O O O O