After treatment of APL cells with AM580 either alone or in combination with granulocyte colony-stimulating factor ( G-CSF ) , the compound induces granulocytic maturation , as assessed by determination of the levels of leukocyte alkaline phosphatase , CD11b , CD33 , and G-CSF receptor mRNA , at concentrations that are 10- to 100-fold lower than those of ATRA necessary to produce similar effects .
after treatment of apl cells with am580 either alone or in combination with granulocyte colony-stimulating factor ( g-csf ) , the compound induces granulocytic maturation , as assessed by determination of the levels of leukocyte alkaline phosphatase , cd11b , cd33 , and g-csf receptor mrna , at concentrations that are 10- to 100-fold lower than those of atra necessary to produce similar effects .
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