Binding experiments , using COS-7 cells transiently transfected with PML-RAR and the normal RAR alpha , show that AM580 has a lower affinity than ATRA for both receptors .
binding experiments , using cos-7 cells transiently transfected with pml-rar and the normal rar alpha , show that am580 has a lower affinity than atra for both receptors .
O O O O B-cell_line I-cell_line O O O B-protein_molecule O O O B-protein_molecule I-protein_molecule O O O B-other_organic_compound O O O O O B-other_organic_compound O O O O