Using these drugs as probes , chemists and biologists have uncovered several intracellular signalling molecules bridging the generation of second-messenger Ca2+ ions and the transcriptional activation of IL-2 , among which are calmodulin , calcineurin and the nuclear factor of activated T cells ( NF-AT ) .
using these drugs as probes , chemists and biologists have uncovered several intracellular signalling molecules bridging the generation of second-messenger ca2+ ions and the transcriptional activation of il-2 , among which are calmodulin , calcineurin and the nuclear factor of activated t cells ( nf-at ) .
O O O O O O O O O O O O O O O O O O O B-atom B-atom O O O B-other_name I-other_name O B-protein_molecule O O O O B-protein_molecule O B-protein_molecule O O B-protein_molecule I-protein_molecule I-protein_molecule B-cell_type B-cell_type I-cell_type O B-protein_molecule O O