tokens: In a previous study , we demonstrated that bufalin , which is an active principle of Chinese medicine , chan'su , caused apoptosis in human leukemia U937 cells by anomalous activation of mitogen-activated protein kinase ( MAPK ) via the signaling pathway of Ras , Raf-1 , and MAPK kinase-1 .
folded_tokens: in a previous study , we demonstrated that bufalin , which is an active principle of chinese medicine , chan'su , caused apoptosis in human leukemia u937 cells by anomalous activation of mitogen-activated protein kinase ( mapk ) via the signaling pathway of ras , raf-1 , and mapk kinase-1 .
labels: O O O O O O O O B-other_organic_compound O O O O O O O B-other_name I-other_name O B-other_name O O O O B-cell_line I-cell_line I-cell_line I-cell_line O O O O B-protein_family_or_group I-protein_family_or_group I-protein_family_or_group O B-protein_family_or_group O O O O O O B-protein_molecule O B-protein_molecule O O B-protein_family_or_group O O