IL-4 , a product of the T-helper 0 ( Th0 ) and 2 ( Th2 ) subset , was originally described as a B-cell stimulatory factor and has subsequently been found to suppress IL-1 alpha , IL-1 beta , IL-6 , IL-8 , and TNF-alpha gene expression in monocytes stimulated with LPS , and to upregulate IL-1 receptor antagonist ( IL1-RA ) gene expression .
il-4 , a product of the t-helper 0 ( th0 ) and 2 ( th2 ) subset , was originally described as a b-cell stimulatory factor and has subsequently been found to suppress il-1 alpha , il-1 beta , il-6 , il-8 , and tnf-alpha gene expression in monocytes stimulated with lps , and to upregulate il-1 receptor antagonist ( il1-ra ) gene expression .
B-protein_molecule O O O O O O O O B-cell_type O O O O B-cell_type O O O O O O O O B-protein_family_or_group I-protein_family_or_group I-protein_family_or_group O O O O O O O O O O O O O O O O O O O O O O B-cell_type O O B-lipid O O O O B-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region O O