This transcription factor is activated via the selective phosphorylation , ubiquination and degradation of its inhibitor protein I-kB thereby allowing translocation of NF-kappa B into the nucleus where it upregulates the transcription of a variety of adhesion molecules ( e . g . ICAM-1 , VCAM-1 ) , cytokines ( TNF , IL-1 , IL-6 ) and enzymes ( iNOS ) .
this transcription factor is activated via the selective phosphorylation , ubiquination and degradation of its inhibitor protein i-kb thereby allowing translocation of nf-kappa b into the nucleus where it upregulates the transcription of a variety of adhesion molecules ( e . g . icam-1 , vcam-1 ) , cytokines ( tnf , il-1 , il-6 ) and enzymes ( inos ) .
O B-protein_family_or_group I-protein_family_or_group O O O O O B-other_name O B-other_name O B-other_name O O B-protein_molecule I-protein_molecule I-protein_molecule O O O O B-protein_complex I-protein_complex O O B-cell_component O O O O O O O O O B-protein_family_or_group I-protein_family_or_group O O O O O B-protein_molecule O B-protein_molecule O O B-protein_family_or_group O B-protein_family_or_group O B-protein_molecule O B-protein_molecule O O B-protein_family_or_group O B-protein_molecule O O