The data presented here indicate that ( 1 ) the 12-lipoxygenase activity of murine macrophages is upregulated in vitro and in vivo by IL-4 and/or IL-13 , ( 2 ) this upregulation requires expression of the transcription factor STAT6 , and ( 3 ) the constitutive expression of the enzyme appears to be STAT6 independent .
the data presented here indicate that ( 1 ) the 12-lipoxygenase activity of murine macrophages is upregulated in vitro and in vivo by il-4 and/or il-13 , ( 2 ) this upregulation requires expression of the transcription factor stat6 , and ( 3 ) the constitutive expression of the enzyme appears to be stat6 independent .
O O O O O O O O O O B-protein_molecule O O O O O O O O O O O O B-protein_molecule O B-protein_molecule O O O O O O O O O O B-protein_family_or_group I-protein_family_or_group B-protein_molecule O O O O O O O O O O O O O O B-protein_molecule O O