When introduced into interleukin 3 ( IL-3 ) -dependent mouse pro-B lymphocytes , E2A-HLF prevents apoptosis induced by growth factor deprivation , suggesting that IL-3 mediates cell survival through activation of a transcription factor whose activity can be constitutively replaced by the chimeric oncoprotein .
when introduced into interleukin 3 ( il-3 ) -dependent mouse pro-b lymphocytes , e2a-hlf prevents apoptosis induced by growth factor deprivation , suggesting that il-3 mediates cell survival through activation of a transcription factor whose activity can be constitutively replaced by the chimeric oncoprotein .
O O O B-protein_molecule I-protein_molecule O B-protein_molecule O O O B-cell_type I-cell_type O B-protein_molecule O B-other_name O O B-protein_family_or_group I-protein_family_or_group O O O O B-protein_molecule O B-other_name I-other_name O O O O B-protein_family_or_group I-protein_family_or_group O O O O O O O O B-protein_family_or_group I-protein_family_or_group O