These results indicate that CTLA-4 signaling inhibits events early in T cell activation both at IL-2 transcription and at the level of IL-2 -independent events of the cell cycle , and does not simply oppose CD28 -mediated costimulation .
these results indicate that ctla-4 signaling inhibits events early in t cell activation both at il-2 transcription and at the level of il-2 -independent events of the cell cycle , and does not simply oppose cd28 -mediated costimulation .
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