Although IL-2 -induced phosphorylation of IL-2R beta , JAK1 , and STAT5 all required the presence of JAK3 , IL-4 -mediated phosphorylation of JAK1 , STAT6 , and insulin receptor substrates 1 and 2 did not .
although il-2 -induced phosphorylation of il-2r beta , jak1 , and stat5 all required the presence of jak3 , il-4 -mediated phosphorylation of jak1 , stat6 , and insulin receptor substrates 1 and 2 did not .
O B-protein_molecule O O O B-protein_molecule I-protein_molecule O B-protein_molecule O O B-protein_molecule O O O O O B-protein_molecule O B-protein_molecule O O O B-protein_molecule O B-protein_molecule O O B-protein_family_or_group I-protein_family_or_group O O O O O O O