Finally , we show by both footprint analysis and functional assays that the ability of the G + C-rich region to increase alpha-globin promoter activity from a stably integrated alpha-globin gene is mediated by its multiple binding sites for the transcription factor Sp1 .
finally , we show by both footprint analysis and functional assays that the ability of the g + c-rich region to increase alpha-globin promoter activity from a stably integrated alpha-globin gene is mediated by its multiple binding sites for the transcription factor sp1 .
O O O O O O B-other_name I-other_name O B-other_name I-other_name O O O O O B-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region O O B-DNA_domain_or_region I-DNA_domain_or_region O O O O O B-DNA_domain_or_region I-DNA_domain_or_region O O O O B-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region O O B-protein_family_or_group I-protein_family_or_group B-protein_molecule O