In contrast , induction of differentiation but not of proliferation was followed by a 25- to 30-fold increase in the nuclear level of the tumor suppressor proteins p53 ( wild type ) , pRb , and p130/Rb2 and of the p53-dependent cyclin kinase inhibitor p21/Cip1 .
in contrast , induction of differentiation but not of proliferation was followed by a 25- to 30-fold increase in the nuclear level of the tumor suppressor proteins p53 ( wild type ) , prb , and p130/rb2 and of the p53-dependent cyclin kinase inhibitor p21/cip1 .
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