Integration of the signals generated by TCR and CD28 engagement occurs along this pathway , which then bifurcates to induce I kappa B phosphorylation and NF-kappa B activation on the one hand , and JNK activation and c-Jun phosphorylation on the other .
integration of the signals generated by tcr and cd28 engagement occurs along this pathway , which then bifurcates to induce i kappa b phosphorylation and nf-kappa b activation on the one hand , and jnk activation and c-jun phosphorylation on the other .
O O O O O O B-protein_molecule O B-protein_molecule O O O O O O O O O O O B-protein_molecule I-protein_molecule I-protein_molecule O O B-protein_molecule I-protein_molecule O O O O O O O B-protein_molecule O O B-protein_molecule O O O O O