To determine whether enhancer elements in addition to the highly conserved octamer ( OCTA ) -nucleotide motif are important for lymphoid-specific expression of the immunoglobulin heavy-chain ( IgH ) gene , we have investigated the effect of mutating the binding site for a putative additional lymphoid-specific transcription factor , designated NF-microB , in the murine IgH enhancer .
to determine whether enhancer elements in addition to the highly conserved octamer ( octa ) -nucleotide motif are important for lymphoid-specific expression of the immunoglobulin heavy-chain ( igh ) gene , we have investigated the effect of mutating the binding site for a putative additional lymphoid-specific transcription factor , designated nf-microb , in the murine igh enhancer .
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