A dominant-negative mutant of NF-kappaB p50 that binds DNA but fails to interact with Ets proteins inhibits the synergistic activation of the HIV-1 and HIV-2 enhancers by NF-kappaB ( p50 + p65 ) and Ets-1 , suggesting that physical interaction between Ets and NF-kappaB proteins is required for the transcriptional activity of the HIV-1 and HIV-2 enhancers .
a dominant-negative mutant of nf-kappab p50 that binds dna but fails to interact with ets proteins inhibits the synergistic activation of the hiv-1 and hiv-2 enhancers by nf-kappab ( p50 + p65 ) and ets-1 , suggesting that physical interaction between ets and nf-kappab proteins is required for the transcriptional activity of the hiv-1 and hiv-2 enhancers .
O O O O B-protein_subunit I-protein_subunit O O O O O O O O B-protein_family_or_group I-protein_family_or_group O O B-other_name I-other_name O O O O O O O B-protein_complex O B-protein_subunit O B-protein_subunit O O B-protein_molecule O O O O O O B-protein_family_or_group O B-protein_complex O O O O O B-other_name I-other_name O O O O O O O