Our results provide the first evidence that both GATA-1 and C/EBPbeta synergistically transactivate the promoter of an eosinophil-specific granule protein gene and that FOG may act as a negative cofactor for the eosinophil lineage , unlike its positively regulatory function for the erythroid and megakaryocyte lineages .
our results provide the first evidence that both gata-1 and c/ebpbeta synergistically transactivate the promoter of an eosinophil-specific granule protein gene and that fog may act as a negative cofactor for the eosinophil lineage , unlike its positively regulatory function for the erythroid and megakaryocyte lineages .
O O O O O O O O B-protein_molecule O B-protein_molecule O O O B-DNA_domain_or_region O O B-DNA_family_or_group I-DNA_family_or_group I-DNA_family_or_group I-DNA_family_or_group O O B-protein_molecule O O O O O O O O B-cell_type I-cell_type O O O O O O O O O O O O O