We found that overexpression of IkappaB-alpha in endothelial cells using a recombinant adenovirus prevented tumor necrosis factor-alpha ( TNF-alpha ) -induced degradation of IkappaB-alpha and suppressed the upregulation of vascular cell adhesion molecule-1 ( VCAM-1 ) , intercellular adhesion molecule-1 ( ICAM-1 ) , and E-selectin mRNA and surface protein expression and the upregulation of transcripts for the chemokines monocyte chemoattractant protein 1 ( MCP-1 ) and growth-related activity-alpha ( GRO-alpha ) by TNF-alpha .
we found that overexpression of ikappab-alpha in endothelial cells using a recombinant adenovirus prevented tumor necrosis factor-alpha ( tnf-alpha ) -induced degradation of ikappab-alpha and suppressed the upregulation of vascular cell adhesion molecule-1 ( vcam-1 ) , intercellular adhesion molecule-1 ( icam-1 ) , and e-selectin mrna and surface protein expression and the upregulation of transcripts for the chemokines monocyte chemoattractant protein 1 ( mcp-1 ) and growth-related activity-alpha ( gro-alpha ) by tnf-alpha .
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