We have previously shown that NFAT is targeted to inactive calcineurin at a region distinct from the calcineurin active site ( Aramburu , J . , Garcia-Cozar , F . J . , Raghavan , A . , Okamura , H . , Rao , A . , and Hogan , P . G . ( 1998 ) Mol . Cell 1 , 627-637 ) ; this region is also involved in NFAT binding to activated calcineurin , since binding is inhibited by an NFAT peptide spanning the calcineurin docking site on NFAT .
we have previously shown that nfat is targeted to inactive calcineurin at a region distinct from the calcineurin active site ( aramburu , j . , garcia-cozar , f . j . , raghavan , a . , okamura , h . , rao , a . , and hogan , p . g . ( 1998 ) mol . cell 1 , 627-637 ) ; this region is also involved in nfat binding to activated calcineurin , since binding is inhibited by an nfat peptide spanning the calcineurin docking site on nfat .
O O O O O B-protein_molecule O O O O B-protein_molecule O O O O O O B-protein_molecule O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O B-protein_family_or_group O O O B-protein_molecule O O O O O O O B-peptide I-peptide O O B-protein_molecule O O O B-protein_family_or_group O