With respect to arginine residues , only the two single mutations of R-276 and R-394 to alanine showed a dramatic decrease of agonist and antagonist binding whereas the R272A mutation showed only a slight effect .
with respect to arginine residues , only the two single mutations of r-276 and r-394 to alanine showed a dramatic decrease of agonist and antagonist binding whereas the r272a mutation showed only a slight effect .
O O O B-amino_acid_monomer I-amino_acid_monomer O O O O B-other_name I-other_name O B-amino_acid_monomer O B-amino_acid_monomer O B-amino_acid_monomer O O O O O O O O O O O B-amino_acid_monomer O O O O O O O