Three of these mutants contained targeted disruptions of potential functional motifs : the acidic activation domain , a putative GTP -binding motif and two leucine charged domains ( LCD motifs ) .
three of these mutants contained targeted disruptions of potential functional motifs : the acidic activation domain , a putative gtp -binding motif and two leucine charged domains ( lcd motifs ) .
O O O O O O O O O O O O O B-protein_domain_or_region I-protein_domain_or_region I-protein_domain_or_region O O O B-nucleotide O O O O B-amino_acid_monomer O O O B-protein_domain_or_region I-protein_domain_or_region O O