Therefore , to evaluate the mechanism of TPA responsiveness of the SNE motifs and of a related 16-bp SEE ( SRF/ ETS element ) motif found in the HCMV and chimpanzee CMV MIE enhancers , we have examined the functional responses and protein binding properties of multimerized wild-type and mutant elements added upstream to the SCMV MIE or simian virus 40 minimal promoter regions in the U-937 , K-562 , HL-60 , THP-1 , and Jurkat cell lines .
therefore , to evaluate the mechanism of tpa responsiveness of the sne motifs and of a related 16-bp see ( srf/ ets element ) motif found in the hcmv and chimpanzee cmv mie enhancers , we have examined the functional responses and protein binding properties of multimerized wild-type and mutant elements added upstream to the scmv mie or simian virus 40 minimal promoter regions in the u-937 , k-562 , hl-60 , thp-1 , and jurkat cell lines .
O O O O O O O B-other_organic_compound O O O B-DNA_domain_or_region O O O O O O B-DNA_domain_or_region O B-DNA_domain_or_region B-protein_family_or_group O O O O O O O O O O O O O O O O O B-other_name I-other_name O B-other_name I-other_name I-other_name O O O O O O O O O O B-virus B-DNA_domain_or_region O B-virus I-virus O O O O O O B-cell_line O B-cell_line O B-cell_line O B-cell_line O O B-cell_line I-cell_line I-cell_line O