However , a hybrid receptor composed of the extracellular and transmembrane regions of the human type II interleukin-1 fused to the cytoplasmic domain of the human type I IL-1R was capable of transducing a signal across the membrane resulting in a pattern of gene activation identical to that mediated by the type I IL-1R .
however , a hybrid receptor composed of the extracellular and transmembrane regions of the human type ii interleukin-1 fused to the cytoplasmic domain of the human type i il-1r was capable of transducing a signal across the membrane resulting in a pattern of gene activation identical to that mediated by the type i il-1r .
O O O O O O O O O O O O O O B-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule O O O B-protein_domain_or_region I-protein_domain_or_region O O B-protein_domain_or_region I-protein_domain_or_region I-protein_domain_or_region B-protein_molecule O O O O O O O O O O O O O O O O O O O O O O B-protein_domain_or_region I-protein_domain_or_region B-protein_molecule O