FKBP has been shown to catalyze the interconversion of the cis- and trans- rotamers of the peptidyl-prolyl amide bond of peptide substrates ; here we show that rapamycin , like FK506 , is a potent inhibitor of the rotamase activity of FKBP ( Ki = 0 . 2 nM ) .
fkbp has been shown to catalyze the interconversion of the cis- and trans- rotamers of the peptidyl-prolyl amide bond of peptide substrates ; here we show that rapamycin , like fk506 , is a potent inhibitor of the rotamase activity of fkbp ( ki = 0 . 2 nm ) .
B-protein_molecule O O O O O O O O O O O O O O O B-protein_substructure I-protein_substructure I-protein_substructure O B-peptide I-peptide O O O O O B-other_organic_compound O O B-other_organic_compound O O O O O O O B-other_name I-other_name O B-protein_molecule O O O O O O O O O