These data , along with previous reports of rare variant translocations in APL , indicate that while dysregulation of RARA by gene fusion may be essential for the APL phenotype , the particular fusion partner may determine clinicopathological aspects , including presentation , response to treatment with all-trans retinoic acid ( ATRA ) , and prognosis .
these data , along with previous reports of rare variant translocations in apl , indicate that while dysregulation of rara by gene fusion may be essential for the apl phenotype , the particular fusion partner may determine clinicopathological aspects , including presentation , response to treatment with all-trans retinoic acid ( atra ) , and prognosis .
O O O O O O O O O O O O B-other_name O O O O O O B-DNA_domain_or_region O B-other_name I-other_name O O O O O B-other_name O O O O O O O O B-other_name I-other_name O O O O O O O O B-other_organic_compound I-other_organic_compound I-other_organic_compound O B-other_organic_compound O O O O O