Replacement of the NF-kappa B elements in the HIV-1 LTR by a DNA fragment derived from the 5'-flanking region of IFN-stimulated gene 15 ( ISG15 ) , containing the IFN-stimulated response element , partially restored Tat -mediated activation of LTR in T cells as well as in monocytes .
replacement of the nf-kappa b elements in the hiv-1 ltr by a dna fragment derived from the 5'-flanking region of ifn-stimulated gene 15 ( isg15 ) , containing the ifn-stimulated response element , partially restored tat -mediated activation of ltr in t cells as well as in monocytes .
O O O B-protein_molecule I-protein_molecule O O O B-DNA_domain_or_region I-DNA_domain_or_region O O B-DNA_molecule I-DNA_molecule O O O B-DNA_domain_or_region I-DNA_domain_or_region O B-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region O B-DNA_domain_or_region O O O O B-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region O O O B-protein_molecule O O O B-DNA_domain_or_region O B-cell_type I-cell_type O O O O B-cell_type O