However , the histone deacetylase ( HDAC ) inhibitor trichostatin A readily activates an RXR-RAR reporter construct in the multipotent EML cells but not in the committed MPRO promyelocytes , indicating that differences in HDAC-containing repressor complexes in these two closely related but distinct hematopoietic lineages might account for the differential activation of the RXR-RARalpha403 heterodimers that we observed at these different stages of myeloid development .
however , the histone deacetylase ( hdac ) inhibitor trichostatin a readily activates an rxr-rar reporter construct in the multipotent eml cells but not in the committed mpro promyelocytes , indicating that differences in hdac-containing repressor complexes in these two closely related but distinct hematopoietic lineages might account for the differential activation of the rxr-raralpha403 heterodimers that we observed at these different stages of myeloid development .
O O O B-protein_family_or_group I-protein_family_or_group I-protein_family_or_group I-protein_family_or_group I-protein_family_or_group I-protein_family_or_group B-other_organic_compound I-other_organic_compound O O O B-protein_complex O O O O O B-cell_type I-cell_type O O O O O B-cell_type I-cell_type O O O O O B-protein_complex I-protein_complex I-protein_complex O O O O O O O B-cell_type I-cell_type O O O O O O O O B-protein_complex I-protein_complex O O O O O O O O B-other_name I-other_name O