The mutant alleles encode cell-surface IFNgamma receptors that lack the intra-cytoplasmic domain , which , through a combination of impaired recycling , abrogated signalling and normal binding to IFNgamma exert a dominant-negative effect .
the mutant alleles encode cell-surface ifngamma receptors that lack the intra-cytoplasmic domain , which , through a combination of impaired recycling , abrogated signalling and normal binding to ifngamma exert a dominant-negative effect .
O O O O B-protein_family_or_group I-protein_family_or_group I-protein_family_or_group O O O B-protein_domain_or_region I-protein_domain_or_region O O O O O O O B-other_name I-other_name O B-other_name I-other_name O O O O B-protein_molecule O O B-other_name I-other_name O