While the binding of IL-2 to its receptor was recently shown to lead to the activation of two kinases , Jak-1 and Jak-3 , subsequent steps in the signaling pathway to the nucleus that lead to the activation of specific genes had not been characterized .
while the binding of il-2 to its receptor was recently shown to lead to the activation of two kinases , jak-1 and jak-3 , subsequent steps in the signaling pathway to the nucleus that lead to the activation of specific genes had not been characterized .
O O O O B-protein_molecule O O O O O O O O O O O O O B-protein_family_or_group O B-protein_molecule O B-protein_molecule O O O O O O O O O B-cell_component O O O O O O O O O O O O O