Expression of the gene encoding human inosine- 5'-monophosphate dehydrogenase ( IMPDH ) type II , an enzyme catalyzing the rate-limiting step in the generation of guanine nucleotides , is increased more than 10-fold in activated peripheral blood T lymphocytes and is required for T cell activation .
expression of the gene encoding human inosine- 5'-monophosphate dehydrogenase ( impdh ) type ii , an enzyme catalyzing the rate-limiting step in the generation of guanine nucleotides , is increased more than 10-fold in activated peripheral blood t lymphocytes and is required for t cell activation .
O O O O O B-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule O O B-protein_family_or_group O O O O O O O O B-nucleotide I-nucleotide O O O O O O O B-cell_type I-cell_type I-cell_type I-cell_type I-cell_type O O O O B-other_name I-other_name I-other_name O