Activation of CD4 positive T cells is a primary requirement for human immunodeficiency virus ( HIV ) entry , efficient HIV replication , and progression to AIDS , Utilizing CD4 positive T cell lines and purified T cells from normal individuals , we have demonstrated that native envelope glycoproteins of HIV , gp 160 , can induce activation of transcription factor , activated protein-1 ( AP-1 ) .
activation of cd4 positive t cells is a primary requirement for human immunodeficiency virus ( hiv ) entry , efficient hiv replication , and progression to aids , utilizing cd4 positive t cell lines and purified t cells from normal individuals , we have demonstrated that native envelope glycoproteins of hiv , gp 160 , can induce activation of transcription factor , activated protein-1 ( ap-1 ) .
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