Functional studies using human endothelial cells demonstrated that overexpression of CBP rescued cAMP inhibition of NF-kappaB -mediated transcription and transcription mediated by a chimeric protein , GAL4-p65 ( 286-551 ) , which contained the GAL4 DNA binding domain fused to the carboxyl-terminal region of p65 ( amino acids 286-551 ) .
functional studies using human endothelial cells demonstrated that overexpression of cbp rescued camp inhibition of nf-kappab -mediated transcription and transcription mediated by a chimeric protein , gal4-p65 ( 286-551 ) , which contained the gal4 dna binding domain fused to the carboxyl-terminal region of p65 ( amino acids 286-551 ) .
O O O O B-cell_type I-cell_type O O O O B-protein_molecule O B-nucleotide O O B-protein_complex O O O O O O O B-protein_family_or_group I-protein_family_or_group O B-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule O O O O B-protein_domain_or_region I-protein_domain_or_region I-protein_domain_or_region I-protein_domain_or_region O O O B-protein_domain_or_region I-protein_domain_or_region O B-protein_subunit O B-protein_domain_or_region I-protein_domain_or_region I-protein_domain_or_region O O