As a first step toward elucidating the function of Cbl in TCR -initiated signaling , we evaluated the ability of wild-type Cbl or a transforming Cbl mutant ( 70Z/3 ) to induce transcriptional activation of a nuclear factor of activated T cells ( NFAT ) element derived from the interleukin 2 ( IL2 ) promoter in transiently cotransfected Jurkat-TAg T cells .
as a first step toward elucidating the function of cbl in tcr -initiated signaling , we evaluated the ability of wild-type cbl or a transforming cbl mutant ( 70z/3 ) to induce transcriptional activation of a nuclear factor of activated t cells ( nfat ) element derived from the interleukin 2 ( il2 ) promoter in transiently cotransfected jurkat-tag t cells .
O O O O O O O O O B-protein_molecule O B-protein_family_or_group O O O O O O O O B-protein_molecule B-protein_molecule O O O B-protein_molecule O O O O O O O O O O B-protein_family_or_group I-protein_family_or_group I-protein_family_or_group I-protein_family_or_group B-cell_type I-cell_type O B-protein_family_or_group O O O O O B-protein_molecule I-protein_molecule O B-protein_molecule O O O O O B-cell_line B-cell_type I-cell_type O