Upon cell activation , displacement of the autoinhibitory domain by calmodulin binding allows NFAT to bind additionally to the calcineurin active site , thus positioning NFAT for immediate dephosphorylation at functional phosphoserine residues .
upon cell activation , displacement of the autoinhibitory domain by calmodulin binding allows nfat to bind additionally to the calcineurin active site , thus positioning nfat for immediate dephosphorylation at functional phosphoserine residues .
O O O O O O O B-protein_domain_or_region I-protein_domain_or_region O B-protein_molecule O O B-protein_family_or_group O O O O O B-protein_molecule O O O O O B-protein_family_or_group O O O O O B-amino_acid_monomer I-amino_acid_monomer O