Incubation of B-chronic lymphocytic leukemia ( B-CLL ) cells with phorbol esters resulted in the phosphorylation of two major PKC substrates , MARCKS ( myristoylated , alanine-rich C kinase substrate ) and MRP ( MARCKS -related protein ) , and of a third protein , with an apparent m . w . of 60 , 000 that was the most prominent protein kinase C substrate in these cells .
incubation of b-chronic lymphocytic leukemia ( b-cll ) cells with phorbol esters resulted in the phosphorylation of two major pkc substrates , marcks ( myristoylated , alanine-rich c kinase substrate ) and mrp ( marcks -related protein ) , and of a third protein , with an apparent m . w . of 60 , 000 that was the most prominent protein kinase c substrate in these cells .
O O B-cell_line I-cell_line I-cell_line I-cell_line I-cell_line I-cell_line I-cell_line O B-other_organic_compound I-other_organic_compound O O O O O O O B-protein_family_or_group I-protein_family_or_group O B-protein_family_or_group O B-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule O O B-protein_molecule O B-protein_family_or_group O O O O O O O O O O O O O O O O O O O O O O O O O O B-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule O O O O