A transcription factor , NF-AT , which is essential for early T-cell gene activation , seems to be a specific target of cyclosporin A and FK506 action because transcription directed by this protein is blocked in T cells treated with these drugs , with little or no effect on other transcription factors such as AP-1 and NF-kappa B .
a transcription factor , nf-at , which is essential for early t-cell gene activation , seems to be a specific target of cyclosporin a and fk506 action because transcription directed by this protein is blocked in t cells treated with these drugs , with little or no effect on other transcription factors such as ap-1 and nf-kappa b .
O B-protein_family_or_group I-protein_family_or_group O B-protein_molecule O O O O O O B-other_name I-other_name I-other_name O O O O O O O O B-other_organic_compound O O B-other_organic_compound O O B-other_name O O O O O O O B-cell_type I-cell_type O O O O O O O O O O O O B-protein_family_or_group I-protein_family_or_group O O B-protein_molecule O B-protein_molecule I-protein_molecule O