We showed that the interaction of SS RBC at 2% concentration in the presence of multimers of von Willebrand factor ( vWf ) , derived from endothelial cell-derived conditioned medium ( E-CM ) with cultured human umbilical vein endothelial cells ( HUVEC ) , resulted in a fivefold increased formation of thiobarbituric acid-reactive substances ( TBARS ) and activation of the transcription factor NF-kB , both indicators of cellular oxidant stress .
we showed that the interaction of ss rbc at 2% concentration in the presence of multimers of von willebrand factor ( vwf ) , derived from endothelial cell-derived conditioned medium ( e-cm ) with cultured human umbilical vein endothelial cells ( huvec ) , resulted in a fivefold increased formation of thiobarbituric acid-reactive substances ( tbars ) and activation of the transcription factor nf-kb , both indicators of cellular oxidant stress .
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