Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription .
oncogenic forms of notch1 lacking either the primary binding site for rbp-jkappa or nuclear localization sequences retain the ability to associate with rbp-jkappa and activate transcription .
O O O B-protein_molecule O O O B-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region O B-protein_molecule O B-protein_substructure I-protein_substructure I-protein_substructure O O O O O O B-protein_molecule O O O O