In addition , pretreatment of the cells with the proteasome inhibitor N-Ac-Leu-Leu-norleucinal inhibits this ligand-induced degradation and , in agreement with previous studies , stabilizes a hyperphosphorylated form of the human I kappa B alpha protein .
in addition , pretreatment of the cells with the proteasome inhibitor n-ac-leu-leu-norleucinal inhibits this ligand-induced degradation and , in agreement with previous studies , stabilizes a hyperphosphorylated form of the human i kappa b alpha protein .
O O O O O O O O O B-protein_complex O B-other_organic_compound O O O O O O O O O O O O O O O O O O B-protein_molecule B-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule O O