However , the two SH2 domains of SHP1 did not facilitate its recognition of ZAP-70 and Syk as substrates in intact cells .
however , the two sh2 domains of shp1 did not facilitate its recognition of zap-70 and syk as substrates in intact cells .
O O O O B-protein_domain_or_region I-protein_domain_or_region O B-protein_molecule O O O O O O B-protein_molecule O B-protein_molecule O O O O O O