A 40-fold stimulation of chloramphenicol acetyltransferase activity mediated by four tandem repeats of the SNE could be induced within 2 h ( and up to 250-fold within 6 h ) after addition of TPA in DNA-transfected U-937 cells , indicating that the stimulation appeared likely to be a true protein kinase C -mediated signal transduction event rather than a differentiation response .
a 40-fold stimulation of chloramphenicol acetyltransferase activity mediated by four tandem repeats of the sne could be induced within 2 h ( and up to 250-fold within 6 h ) after addition of tpa in dna-transfected u-937 cells , indicating that the stimulation appeared likely to be a true protein kinase c -mediated signal transduction event rather than a differentiation response .
O O O O B-protein_molecule I-protein_molecule O O O O B-DNA_domain_or_region I-DNA_domain_or_region O O B-DNA_domain_or_region O O O O O O O O O O O O O O O O O O B-other_organic_compound O B-cell_line B-cell_line I-cell_line O O O O O O O O O O O B-protein_molecule I-protein_molecule I-protein_molecule O O O O O O O B-other_name I-other_name O