While the activation of the IL-2 promoter and an NFAT -driven minimal promoter by Tpl-2 was fully blocked by the dominant negative mutant NFAT delta418 , it was only partially blocked by the calcineurin inhibitor cyclosporin A suggesting that the Tpl-2 -mediated NFAT activation is under the control of a combination of calcineurin- dependent and independent pathways .
while the activation of the il-2 promoter and an nfat -driven minimal promoter by tpl-2 was fully blocked by the dominant negative mutant nfat delta418 , it was only partially blocked by the calcineurin inhibitor cyclosporin a suggesting that the tpl-2 -mediated nfat activation is under the control of a combination of calcineurin- dependent and independent pathways .
O O O O O B-protein_molecule O O O B-protein_molecule O O O O B-protein_molecule O O O O O B-protein_family_or_group I-protein_family_or_group I-protein_family_or_group B-protein_molecule O O O O O O O O O B-protein_molecule O B-other_organic_compound I-other_organic_compound O O O B-protein_molecule O B-protein_molecule O O O O O O O O O O O O O O O