Lastly , we demonstrated that p38 kinase activity played a central role in IL-1beta production and that it was rapidly up-regulated following infection .
lastly , we demonstrated that p38 kinase activity played a central role in il-1beta production and that it was rapidly up-regulated following infection .
O O O O O B-protein_molecule O O O O O O O B-protein_molecule O O O O O O O O O O