In this work , we report that these anergic T cells are defective in their ability to up-regulate protein binding and transactivation at two critical IL-2 DNA enhancer elements : NF-AT ( nuclear factor of activated T cells ; a sequence that binds a heterotrimeric NFATp , Fos , and Jun protein complex ) and Activator Protein-1 ( AP-1 ) ( that binds Fos and Jun heterodimers ) .
in this work , we report that these anergic t cells are defective in their ability to up-regulate protein binding and transactivation at two critical il-2 dna enhancer elements : nf-at ( nuclear factor of activated t cells ; a sequence that binds a heterotrimeric nfatp , fos , and jun protein complex ) and activator protein-1 ( ap-1 ) ( that binds fos and jun heterodimers ) .
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