CONCLUSIONS : Our results establish that PI 3-kinase can both positively and negatively regulate T-cell function , and uncover a previously unrecognized function for PI 3-kinase in T cells as a selective negative regulator of TCR -signalling events and therefore as a determinant of T-cell homeostasis .
conclusions : our results establish that pi 3-kinase can both positively and negatively regulate t-cell function , and uncover a previously unrecognized function for pi 3-kinase in t cells as a selective negative regulator of tcr -signalling events and therefore as a determinant of t-cell homeostasis .
O O O O O O B-protein_molecule I-protein_molecule O O O O O O B-other_name I-other_name O O O O O O O O B-protein_molecule I-protein_molecule O B-cell_type I-cell_type O O O O O O B-protein_family_or_group O O O O O O O O B-other_name I-other_name O