Further , CTLA-4 engagement inhibited progression through the cell cycle by inhibiting the production of cyclin D3 , cyclin-dependent kinase ( cdk ) 4 , and cdk6 when the T cells were stimulated with anti-CD3/ CD28 and with anti-CD3 alone .
further , ctla-4 engagement inhibited progression through the cell cycle by inhibiting the production of cyclin d3 , cyclin-dependent kinase ( cdk ) 4 , and cdk6 when the t cells were stimulated with anti-cd3/ cd28 and with anti-cd3 alone .
O O B-protein_molecule O O O O O B-other_name I-other_name O O O O O B-protein_molecule I-protein_molecule O B-protein_molecule I-protein_molecule B-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule O O B-protein_molecule O O B-cell_type I-cell_type O O O B-protein_family_or_group B-protein_molecule O O B-protein_family_or_group O O