Specific inhibitors of p70 ( S6 ) -kinase ( rapamycin ) , and Gi protein ( pertussis toxin ) , prevented induction of IL-10 production by gp41 in monocytes , while inhibitors of the phosphatidylinositol 3-kinase ( PI 3-kinase ) ( wortmannin ) and mitogen-activated protein kinase ( MAPK ) pathway ( PD 98059 ) did not .
specific inhibitors of p70 ( s6 ) -kinase ( rapamycin ) , and gi protein ( pertussis toxin ) , prevented induction of il-10 production by gp41 in monocytes , while inhibitors of the phosphatidylinositol 3-kinase ( pi 3-kinase ) ( wortmannin ) and mitogen-activated protein kinase ( mapk ) pathway ( pd 98059 ) did not .
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