Nonresponders had a significant increase both in the number of binding sites and in the apparent dissociation constant compared with responders ( P = 0 . 045 ; P = 0 . 029 ) .
nonresponders had a significant increase both in the number of binding sites and in the apparent dissociation constant compared with responders ( p = 0 . 045 ; p = 0 . 029 ) .
B-multi_cell O O O O O O O O O B-protein_domain_or_region I-protein_domain_or_region O O O O O O O O B-multi_cell O O O O O O O O O O O O O O