However , p38 MAPK is activated strongly and synergistically by either CD3/CD28 coligation or PMA/Ca2+ ionophore stimulation , which mimics TCR - CD3/CD28 -mediated signaling .
however , p38 mapk is activated strongly and synergistically by either cd3/cd28 coligation or pma/ca2+ ionophore stimulation , which mimics tcr - cd3/cd28 -mediated signaling .
O O B-protein_molecule I-protein_molecule O O O O O O O B-protein_complex O O B-other_name I-other_name I-other_name O O O B-protein_family_or_group O B-protein_complex O O O