Costimulation results in the activation of a signaling pathway that leads to the simultaneous induction of the two transcription factors , AP-1 and NF-kappa B .
costimulation results in the activation of a signaling pathway that leads to the simultaneous induction of the two transcription factors , ap-1 and nf-kappa b .
O O O O O O O O O O O O O O O O O O B-protein_family_or_group I-protein_family_or_group O B-protein_molecule O B-protein_molecule I-protein_molecule O