Site-directed mutagenesis of binding sites for the repressor proteins BP1 and BP2 in the upstream portion of the beta globin gene flanking region led to a 4-6 fold increase in promoter activity .
site-directed mutagenesis of binding sites for the repressor proteins bp1 and bp2 in the upstream portion of the beta globin gene flanking region led to a 4-6 fold increase in promoter activity .
B-other_name I-other_name O O O O O O O O O O O O B-DNA_domain_or_region I-DNA_domain_or_region O O B-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region O O O O O O O B-other_name I-other_name O