Hence , the PRL -induced biphasic expression of the IRF-1 gene appears to be controlled by separate PRL -responsive elements : elements in the first 0 . 2 kb of the IRF-1 promoter region act during early activation , and elements between 0 . 2 and 1 . 7 kb act in concert with the proximal 0 . 2-kb region during S phase progression .
hence , the prl -induced biphasic expression of the irf-1 gene appears to be controlled by separate prl -responsive elements : elements in the first 0 . 2 kb of the irf-1 promoter region act during early activation , and elements between 0 . 2 and 1 . 7 kb act in concert with the proximal 0 . 2-kb region during s phase progression .
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