Tat also superactivates the HIV-1 promoter through a TAR -independent mechanism , including tumor necrosis factor alpha-induced and protein kinase C ( PKC ) -dependent activation of NF-kappa B , and inhibitors of Tat and NF-kappa B cooperatively down-regulate this Tat -mediated LTR superactivation .
tat also superactivates the hiv-1 promoter through a tar -independent mechanism , including tumor necrosis factor alpha-induced and protein kinase c ( pkc ) -dependent activation of nf-kappa b , and inhibitors of tat and nf-kappa b cooperatively down-regulate this tat -mediated ltr superactivation .
O O O O B-virus O O O B-DNA_domain_or_region O O O O O O O O O O O O O B-protein_molecule O O O O B-protein_complex I-protein_complex O O O O B-protein_molecule O B-protein_complex I-protein_complex O O O B-protein_molecule O B-DNA_domain_or_region O O