Whereas the CRE site was essential in mediating the negative activity of the upstream regulatory region in Jurkat but not in HeLa cells , mutation of the Sp1/AP-2 site decreased promoter activity in both cell lines .
whereas the cre site was essential in mediating the negative activity of the upstream regulatory region in jurkat but not in hela cells , mutation of the sp1/ap-2 site decreased promoter activity in both cell lines .
O O B-DNA_domain_or_region I-DNA_domain_or_region O O O O O B-other_name I-other_name O O B-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region O B-cell_line O O O B-cell_line I-cell_line O O O O B-DNA_domain_or_region I-DNA_domain_or_region O B-other_name I-other_name O O O O O