The mechanisms by which these promoters of cell growth exert their inhibitory effects vary , but in most instances they involve a disruption of the IFN-alpha/beta-induced transcription complex ISGF3 such that the DNA-binding component of this complex ( the 48-kDa ISGF3gamma protein ) does not bind to the interferon-stimulated response element ( ISRE ) .
the mechanisms by which these promoters of cell growth exert their inhibitory effects vary , but in most instances they involve a disruption of the ifn-alpha/beta-induced transcription complex isgf3 such that the dna-binding component of this complex ( the 48-kda isgf3gamma protein ) does not bind to the interferon-stimulated response element ( isre ) .
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