This report indicates that the emergence of CTLs against immunorecessive epitopes following multiple administrations of Ad vectors lacking immunodominant antigens is dependent on haplotype and could present an obstacle to gene therapy in an MHC -diverse human population .
this report indicates that the emergence of ctls against immunorecessive epitopes following multiple administrations of ad vectors lacking immunodominant antigens is dependent on haplotype and could present an obstacle to gene therapy in an mhc -diverse human population .
O O O O O O O B-cell_type O B-protein_domain_or_region I-protein_domain_or_region O O O O B-other_artificial_source I-other_artificial_source O O O O O O B-other_name O O O O O O B-other_name I-other_name O O B-protein_complex O O O O