To investigate whether both lipoxygenase isoforms exhibit a similar regulatory response toward cytokine stimulation , we studied the regulation of the leukocyte-type 12-lipoxygenase of murine peritoneal macrophages by interleukins and found that the activity of this enzyme is upregulated in a dose-dependent manner when the cells were cultured in the presence of the IL-4 or IL-13 but not by IL-10 .
to investigate whether both lipoxygenase isoforms exhibit a similar regulatory response toward cytokine stimulation , we studied the regulation of the leukocyte-type 12-lipoxygenase of murine peritoneal macrophages by interleukins and found that the activity of this enzyme is upregulated in a dose-dependent manner when the cells were cultured in the presence of the il-4 or il-13 but not by il-10 .
O O O O B-protein_family_or_group I-protein_family_or_group O O O O O O B-protein_family_or_group O O O O O O O O B-protein_molecule I-protein_molecule O B-cell_type B-cell_type I-cell_type O B-protein_family_or_group O O O O O O O B-protein_family_or_group O O O O B-other_name I-other_name O O O O O O O O O O B-protein_molecule O B-protein_molecule O O O B-protein_molecule O