The transmembrane domains are well conserved , but there is striking sequence divergence of the carboxy-terminal cytoplasmic domain essential for B-cell immortalization and interaction with the tumor necrosis factor receptor signaling pathway .
the transmembrane domains are well conserved , but there is striking sequence divergence of the carboxy-terminal cytoplasmic domain essential for b-cell immortalization and interaction with the tumor necrosis factor receptor signaling pathway .
O O O O O O O O O O O O O O O B-protein_domain_or_region I-protein_domain_or_region I-protein_domain_or_region O O B-cell_type O O O O O B-protein_family_or_group I-protein_family_or_group I-protein_family_or_group I-protein_family_or_group O O O