The cytokines interleukin-1 beta ( IL-1 beta ) and tumor necrosis factor alpha ( TNF-alpha ) are released by mononuclear phagocytes in vitro after stimulation with mycobacteria and are considered to mediate pathophysiologic events , including granuloma formation and systemic symptoms .
the cytokines interleukin-1 beta ( il-1 beta ) and tumor necrosis factor alpha ( tnf-alpha ) are released by mononuclear phagocytes in vitro after stimulation with mycobacteria and are considered to mediate pathophysiologic events , including granuloma formation and systemic symptoms .
O O O O O B-protein_molecule I-protein_molecule O O O O O O O B-protein_molecule O O O O B-cell_type I-cell_type O O O O O B-mono_cell O O O O O O O O O B-other_name I-other_name O O O O