In contrast , engagement of the TCR by class II MHC/superantigen , either with or without CD28 ligation , resulted in the induction of NF-AT , AP-1 , and NF-kappaB as well as IL-2 production .
in contrast , engagement of the tcr by class ii mhc/superantigen , either with or without cd28 ligation , resulted in the induction of nf-at , ap-1 , and nf-kappab as well as il-2 production .
O O O O O O B-protein_family_or_group O B-protein_molecule I-protein_molecule I-protein_molecule O O O O O B-protein_molecule O O O O O O O B-protein_family_or_group O B-protein_molecule O O B-protein_complex O O O B-protein_molecule O O