Treatment of T cells with the selective PKC inhibitor GF109203X abrogates the PMA -induced IkB alpha phosphorylation /degradation irrespective of activation of Ca ( 2+ ) -dependent pathways , but not the phosphorylation and degradation of IkB alpha induced by TNF-alpha , a PKC -independent stimulus .
treatment of t cells with the selective pkc inhibitor gf109203x abrogates the pma -induced ikb alpha phosphorylation /degradation irrespective of activation of ca ( 2+ ) -dependent pathways , but not the phosphorylation and degradation of ikb alpha induced by tnf-alpha , a pkc -independent stimulus .
O O B-cell_type I-cell_type O O O B-protein_molecule O B-other_organic_compound O O B-other_organic_compound O B-protein_molecule I-protein_molecule O O O O O O B-atom I-atom I-atom I-atom O O O O O O O O O O B-protein_molecule I-protein_molecule O O B-protein_molecule O O B-protein_molecule O O O