We found that : ( i ) both CTCF mRNA and protein are down-regulated during terminal differentiation in most cell lines tested ; ( ii ) CTCF down-regulation is retarded and less pronounced than that of c-myc ; ( iii ) CTCF protein is differentially phosphorylated and the phosphorylation profiles depend on the differentiation pathway .
we found that : ( i ) both ctcf mrna and protein are down-regulated during terminal differentiation in most cell lines tested ; ( ii ) ctcf down-regulation is retarded and less pronounced than that of c-myc ; ( iii ) ctcf protein is differentially phosphorylated and the phosphorylation profiles depend on the differentiation pathway .
O O O O O O O O B-protein_molecule O O O O O O B-other_name I-other_name O O O O O O O O O B-protein_molecule O O O O O O O O O B-DNA_domain_or_region O O O O B-protein_molecule O O O O O O O O O O O B-other_name I-other_name O