Together these data demonstrate that the v-abl protein specifically interferes with light-chain gene rearrangement by suppressing at least two pathways essential for this stage of B-cell differentiation and suggest that tyrosine phosphorylation is important in regulating RAG gene expression .
together these data demonstrate that the v-abl protein specifically interferes with light-chain gene rearrangement by suppressing at least two pathways essential for this stage of b-cell differentiation and suggest that tyrosine phosphorylation is important in regulating rag gene expression .
O O O O O O B-protein_molecule I-protein_molecule O O O B-DNA_domain_or_region I-DNA_domain_or_region O O O O O O O O O O O O B-cell_type O O O O B-amino_acid_monomer O O O O O B-DNA_domain_or_region I-DNA_domain_or_region O O