A role for changes in immunophilins , causing glucocorticoid resistance in neotropical primates , is supported by the following : the changes in FKBP51 and FKBP52 were observed in cells from other neotropical primates with glucocorticoid resistance ; the elevated level of FKBP51 was reflected in an abundance of FKBP51 in heat shock protein 90 complexes in SML ; when cytosols of SML and L929 cells were mixed , the decrease in GR binding was associated with incorporation of FKBP51 into GR heterocomplexes ; the effect of SML cytosol on GR binding was reproduced with cytosol from COS cells expressing squirrel monkey FKBP51 ; and both the effect of SML cytosol on GR binding and the incorporation of FKBP51 into GR heterocomplexes were blocked by FK506 .
a role for changes in immunophilins , causing glucocorticoid resistance in neotropical primates , is supported by the following : the changes in fkbp51 and fkbp52 were observed in cells from other neotropical primates with glucocorticoid resistance ; the elevated level of fkbp51 was reflected in an abundance of fkbp51 in heat shock protein 90 complexes in sml ; when cytosols of sml and l929 cells were mixed , the decrease in gr binding was associated with incorporation of fkbp51 into gr heterocomplexes ; the effect of sml cytosol on gr binding was reproduced with cytosol from cos cells expressing squirrel monkey fkbp51 ; and both the effect of sml cytosol on gr binding and the incorporation of fkbp51 into gr heterocomplexes were blocked by fk506 .
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