Preincubation of endothelial cells with endotoxin [ lipopolysaccharide ( LPS ) , 1 microgram/ml ] led to a 4-fold increase in subsequent adherence of polymorphonuclear leukocytes ( P < 0 . 0001 , n = 10 ) to endothelial cells , an increase that was markedly attenuated when endothelial cells were treated with dexamethasone ( IC50 < 1 nM , P < 0 . 0001 , n = 6 or 7 ) during preincubation with LPS .
preincubation of endothelial cells with endotoxin [ lipopolysaccharide ( lps ) , 1 microgram/ml ] led to a 4-fold increase in subsequent adherence of polymorphonuclear leukocytes ( p < 0 . 0001 , n = 10 ) to endothelial cells , an increase that was markedly attenuated when endothelial cells were treated with dexamethasone ( ic50 < 1 nm , p < 0 . 0001 , n = 6 or 7 ) during preincubation with lps .
O O B-cell_type I-cell_type O O O B-lipid O B-lipid O O O O O O O O O O O O O O B-cell_type I-cell_type O O O O O O O O O O O O B-cell_type I-cell_type O O O O O O O O B-cell_type I-cell_type O O O B-lipid O O O O O O O O O O O O O O O O O O O O O B-lipid O