We report that a constitutively active form of calcineurin partially substitutes for the Ca2+ co-stimulus required to activate the IL-2 promoter elements IL-2A ( which binds the factors OAP and Oct-1 ) and IL-2E ( which binds NF-AT ) , and completely substitutes for the Ca2+ co-stimulus required to stimulate an NF-kappa B -dependent element .
we report that a constitutively active form of calcineurin partially substitutes for the ca2+ co-stimulus required to activate the il-2 promoter elements il-2a ( which binds the factors oap and oct-1 ) and il-2e ( which binds nf-at ) , and completely substitutes for the ca2+ co-stimulus required to stimulate an nf-kappa b -dependent element .
O O O O O O O O B-protein_molecule O O O O B-atom O O O O O B-DNA_domain_or_region I-DNA_domain_or_region O B-DNA_domain_or_region O O O O O B-protein_molecule O B-protein_molecule O O B-DNA_domain_or_region O O O B-protein_family_or_group O O O O O O O B-atom O O O O O B-protein_complex I-protein_complex O O O