Selective phosphatase inhibitors for protein phosphatase 1 ( PP1 ) and 2A ( PP2A ) that do not inhibit calcineurin , such as okadaic acid and calyculin A , also inhibited NFAT activation with IC50s of 87 nM and 4 nM , respectively , suggesting that okadaic acid and related inhibitors may block NFAT activation through the inhibition of PP1 , instead of PP2A .
selective phosphatase inhibitors for protein phosphatase 1 ( pp1 ) and 2a ( pp2a ) that do not inhibit calcineurin , such as okadaic acid and calyculin a , also inhibited nfat activation with ic50s of 87 nm and 4 nm , respectively , suggesting that okadaic acid and related inhibitors may block nfat activation through the inhibition of pp1 , instead of pp2a .
O O O O B-protein_molecule I-protein_molecule I-protein_molecule O B-protein_molecule O O B-protein_molecule O B-protein_molecule O O O O O B-protein_molecule O O O B-other_organic_compound I-other_organic_compound O B-other_organic_compound I-other_organic_compound O O O B-protein_molecule O O B-other_name O O O O O O O O O O O B-other_organic_compound I-other_organic_compound O O O O O B-protein_molecule O O O O O B-protein_molecule O O O B-protein_molecule O