The effect of Rho on AP-1 is independent of the mitogen-activated protein kinase pathway , as a dominant-negative MEK and a MEK inhibitor ( PD98059 ) did not affect Rho -induced AP-1 activity .
the effect of rho on ap-1 is independent of the mitogen-activated protein kinase pathway , as a dominant-negative mek and a mek inhibitor ( pd98059 ) did not affect rho -induced ap-1 activity .
O O O B-protein_molecule O B-protein_molecule O O O O B-protein_family_or_group I-protein_family_or_group I-protein_family_or_group O O O O B-protein_molecule B-protein_molecule O O B-protein_molecule O O B-other_organic_compound O O O O B-protein_molecule O B-protein_molecule O O