Taken together , these findings suggest that AG-490 inhibits the JAK3 -mediated Type II signaling pathway but not the T cell receptor-derived Type I pathway and possesses therapeutic potential for T cell -derived pathologies such as graft-versus-host disease , allergy , and autoimmune disorders .
taken together , these findings suggest that ag-490 inhibits the jak3 -mediated type ii signaling pathway but not the t cell receptor-derived type i pathway and possesses therapeutic potential for t cell -derived pathologies such as graft-versus-host disease , allergy , and autoimmune disorders .
O O O O O O O B-other_artificial_source O O B-protein_molecule O O O O O O O O B-cell_type I-cell_type O O O O O O O O O B-cell_type I-cell_type O O O O B-other_name I-other_name O B-other_name O O B-other_name I-other_name O