However , substitution of the Pro-X-Pro in the BOX1 motif with Ala-X-Ala failed to abolish IL-9 -induced cell proliferation but decreased IL-9 -mediated tyrosine phosphorylation of JAK kinases , insulin receptor substrate-2 , and signal transducer and activator of transcription 3 ( STAT3 ) and expression of c-myc and junB .
however , substitution of the pro-x-pro in the box1 motif with ala-x-ala failed to abolish il-9 -induced cell proliferation but decreased il-9 -mediated tyrosine phosphorylation of jak kinases , insulin receptor substrate-2 , and signal transducer and activator of transcription 3 ( stat3 ) and expression of c-myc and junb .
O O O O O B-protein_domain_or_region O O B-protein_domain_or_region I-protein_domain_or_region O B-protein_domain_or_region O O O B-protein_molecule O O O O O B-protein_molecule O B-amino_acid_monomer O O B-protein_family_or_group I-protein_family_or_group O B-protein_molecule I-protein_molecule I-protein_molecule O O B-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule O B-protein_molecule O O O O B-DNA_domain_or_region O B-DNA_domain_or_region O