In T lymphocytes , the hematopoietic cytokine interleukin-2 ( IL-2 ) uses phosphatidylinositol 3-kinase ( PI 3-kinase ) -induced signaling pathways to regulate E2F transcriptional activity , a critical cell cycle checkpoint .
in t lymphocytes , the hematopoietic cytokine interleukin-2 ( il-2 ) uses phosphatidylinositol 3-kinase ( pi 3-kinase ) -induced signaling pathways to regulate e2f transcriptional activity , a critical cell cycle checkpoint .
O B-cell_type I-cell_type O O B-protein_family_or_group I-protein_family_or_group B-protein_molecule O B-protein_molecule O O B-protein_molecule I-protein_molecule O B-protein_molecule I-protein_molecule O O O O O O B-protein_molecule O O O O O B-other_name I-other_name I-other_name O