Overexpression of wild-type Grf40 in Jurkat cells induced a significant increase of SLP-76 -dependent interleukin ( IL ) -2 promoter and nuclear factor of activated T cell ( NF-AT ) activation upon T cell receptor ( TCR ) stimulation , whereas the COOH-terminal SH3-deleted Grf40 mutant lacked any recognizable increase in IL-2 promoter activity .
overexpression of wild-type grf40 in jurkat cells induced a significant increase of slp-76 -dependent interleukin ( il ) -2 promoter and nuclear factor of activated t cell ( nf-at ) activation upon t cell receptor ( tcr ) stimulation , whereas the cooh-terminal sh3-deleted grf40 mutant lacked any recognizable increase in il-2 promoter activity .
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