We thus propose that during an in vivo chronic response , a narrow range of avidity of the TCR -CD8 complex conditions long-term clonotype persistence , and that the level of CD8 contribution is adjusted to keep clonotypes with variable TCR affinities within this avidity window .
we thus propose that during an in vivo chronic response , a narrow range of avidity of the tcr -cd8 complex conditions long-term clonotype persistence , and that the level of cd8 contribution is adjusted to keep clonotypes with variable tcr affinities within this avidity window .
O O O O O O O O O O O O O O O O O O B-protein_family_or_group O O O O O O O O O O O O B-protein_molecule O O O O O O O O B-protein_family_or_group O O O B-other_name I-other_name O