The DNA change , 2418delA , is considered a mutation that inactivated one BRCA1 allele because it caused a frameshift and generation of a premature stop codon , resulting in synthesis of a truncated peptide as evidenced by an in vitro protein truncation test .
the dna change , 2418dela , is considered a mutation that inactivated one brca1 allele because it caused a frameshift and generation of a premature stop codon , resulting in synthesis of a truncated peptide as evidenced by an in vitro protein truncation test .
O B-other_name I-other_name O B-other_name O O O O B-other_name O O O B-DNA_domain_or_region O O O O O B-other_name O O O O B-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region O O O O O O B-peptide I-peptide O O O O O O O O O O