Therefore , initiation of the EBV lytic cycle by the ZEBRA protein requires a function in addition to transcriptional activation ; a change of serine 186 to alanine in the DNA-binding domain of ZEBRA abolished this additional function and uncovered a new role for the ZEBRA protein in disruption of EBV latency .
therefore , initiation of the ebv lytic cycle by the zebra protein requires a function in addition to transcriptional activation ; a change of serine 186 to alanine in the dna-binding domain of zebra abolished this additional function and uncovered a new role for the zebra protein in disruption of ebv latency .
O O O O O B-virus B-other_name I-other_name O O B-protein_molecule O O O O O O O B-other_name I-other_name O O O O B-amino_acid_monomer I-amino_acid_monomer O B-amino_acid_monomer O O B-protein_domain_or_region I-protein_domain_or_region O B-protein_molecule O O O O O O O O O O O B-protein_molecule O O O O B-virus O O