Furthermore , we confirmed the previous report that FK506 suppressed the PMA / ionomycin -induced activation through authentic kappa B site of immunoglobulin ( Ig ) gene , to which NF-kappa B binding was also decreased by FK506 , indicating that both IL-8 kappa B-like site and Ig kappa B site are FK506 -sensitive in spite of the difference of binding factors .
furthermore , we confirmed the previous report that fk506 suppressed the pma / ionomycin -induced activation through authentic kappa b site of immunoglobulin ( ig ) gene , to which nf-kappa b binding was also decreased by fk506 , indicating that both il-8 kappa b-like site and ig kappa b site are fk506 -sensitive in spite of the difference of binding factors .
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