By using Jurkat and primary human T lymphocytes , we demonstrate that the simultaneous activation of two second messengers of the TCR -initiated signal transduction , protein kinase C ( PKC ) and calcineurin , results in the synergistic activation of the IkappaBalpha kinase ( IKK ) complex but not of another putative IkappaBalpha kinase , p90 ( rsk ) .
by using jurkat and primary human t lymphocytes , we demonstrate that the simultaneous activation of two second messengers of the tcr -initiated signal transduction , protein kinase c ( pkc ) and calcineurin , results in the synergistic activation of the ikappabalpha kinase ( ikk ) complex but not of another putative ikappabalpha kinase , p90 ( rsk ) .
O O B-cell_line O B-cell_type I-cell_type B-cell_type I-cell_type O O O O O O O O O O O O O B-protein_family_or_group O O O O B-protein_molecule I-protein_molecule I-protein_molecule O B-protein_molecule O O B-protein_molecule O O O O O O O O B-protein_molecule O O O O O O O O O B-protein_family_or_group B-protein_molecule O O B-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule O