Furthermore , we show that whereas the expression of the fusion protein AML1/MDS1/EVI1 completely abrogates the growth-inhibitory effect of TGF-beta1 and allows 32Dcl3 cells to proliferate , expression of the normal protein MDS1/EVI1 has the opposite effect , and it strengthens the response of cells to the growth-inhibitory effect of TGF-beta1 .
furthermore , we show that whereas the expression of the fusion protein aml1/mds1/evi1 completely abrogates the growth-inhibitory effect of tgf-beta1 and allows 32dcl3 cells to proliferate , expression of the normal protein mds1/evi1 has the opposite effect , and it strengthens the response of cells to the growth-inhibitory effect of tgf-beta1 .
O O O O O O O O O O O O B-protein_molecule O O O O O O B-protein_molecule O O B-cell_line I-cell_line O O O O O O O O B-DNA_domain_or_region O O O O O O O O O O O O O O O O O B-protein_molecule O