To determine whether BCL-6 mutations represent a tumor-associated phenomenon or reflect a physiologic mechanism , we screened single human tonsillar GC B cells for mutations occurring in the BCL-6 5'-noncoding region and in the Ig variable heavy chain sequences .
to determine whether bcl-6 mutations represent a tumor-associated phenomenon or reflect a physiologic mechanism , we screened single human tonsillar gc b cells for mutations occurring in the bcl-6 5'-noncoding region and in the ig variable heavy chain sequences .
O O O B-protein_molecule O O O O O O O O O O O O O O B-cell_type I-cell_type I-cell_type I-cell_type I-cell_type O O O O O B-protein_molecule O O O O O B-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region O