Here we show that deregulated expression of a single viral gene , ORF 50 , which encodes a transactivator able to selectively upregulate delayed-early viral genes , suffices to disrupt latency and induce the lytic gene cascade in latently infected B cells .
here we show that deregulated expression of a single viral gene , orf 50 , which encodes a transactivator able to selectively upregulate delayed-early viral genes , suffices to disrupt latency and induce the lytic gene cascade in latently infected b cells .
O O O O O O O O O B-DNA_family_or_group I-DNA_family_or_group O B-DNA_domain_or_region I-DNA_domain_or_region O O O O O O O O O B-DNA_family_or_group I-DNA_family_or_group I-DNA_family_or_group O O O O O O O O B-other_name I-other_name I-other_name O B-cell_type I-cell_type I-cell_type I-cell_type O