These data provide the molecular basis for the notion that ( 1 ) part of the anti-atherogenic effect of aspirin may be due to the prevention of the adhesion of sensitized T cells to stressed EC ; ( 2 ) that part of the atherosclerosis-promoting effect of CyA may be due to its potential as an inducer of Hsp60 expression and its inability to down-regulate adhesion molecule expression on EC ; and ( 3 ) that down-regulation of MCP-1 expression by aspirin may result in decreased recruitment of monocytes into the arterial intima beneath stressed EC .
these data provide the molecular basis for the notion that ( 1 ) part of the anti-atherogenic effect of aspirin may be due to the prevention of the adhesion of sensitized t cells to stressed ec ; ( 2 ) that part of the atherosclerosis-promoting effect of cya may be due to its potential as an inducer of hsp60 expression and its inability to down-regulate adhesion molecule expression on ec ; and ( 3 ) that down-regulation of mcp-1 expression by aspirin may result in decreased recruitment of monocytes into the arterial intima beneath stressed ec .
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