We propose that BEAD-1 functions as a boundary that separates the TCR alpha/delta locus into distinct regulatory domains controlled by Edelta and the TCR alpha enhancer , and that it prevents Edelta from opening the chromatin of the TCR alpha joining gene segments for VDJ recombination at an early stage of T cell development .
we propose that bead-1 functions as a boundary that separates the tcr alpha/delta locus into distinct regulatory domains controlled by edelta and the tcr alpha enhancer , and that it prevents edelta from opening the chromatin of the tcr alpha joining gene segments for vdj recombination at an early stage of t cell development .
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