Through systematic DNA footprinting of the TNF ( encoding tumour necrosis factor , TNF ) promoter region , we have identified a single nucleotide polymorphism ( SNP ) that causes the helix-turn-helix transcription factor OCT-1 to bind to a novel region of complex protein-DNA interactions and alters gene expression in human monocytes .
through systematic dna footprinting of the tnf ( encoding tumour necrosis factor , tnf ) promoter region , we have identified a single nucleotide polymorphism ( snp ) that causes the helix-turn-helix transcription factor oct-1 to bind to a novel region of complex protein-dna interactions and alters gene expression in human monocytes .
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