Since neither DNA binding nor protein dimerization through the bZIP domain of HLF is required for this effect , we propose mechanisms whereby protein-protein interactions with the amino-terminal region of E2A allow the chimera to act as a transcriptional cofactor to alter the expression of genes regulating the apoptotic machinery in pro-B cells .
since neither dna binding nor protein dimerization through the bzip domain of hlf is required for this effect , we propose mechanisms whereby protein-protein interactions with the amino-terminal region of e2a allow the chimera to act as a transcriptional cofactor to alter the expression of genes regulating the apoptotic machinery in pro-b cells .
O O B-other_name I-other_name I-other_name I-other_name I-other_name O O B-protein_domain_or_region I-protein_domain_or_region O B-protein_molecule O O O O O O O O O O B-other_name I-other_name O O O O O B-protein_molecule O O B-protein_family_or_group O O O O O O O O O O O O O O O O O B-cell_type I-cell_type O