Normal human pulmonary alveolar macrophages ( PAM ) are less sensitive to 1 , 25 ( OH ) 2D3 than PBM , despite similar vitamin D receptor content ; however , both PBM and PAM respond to exogenous 1 , 25- ( OH ) 2D3 by inhibiting 1 , 25 ( OH ) 2D3 synthesis and inducing 1 , 25 ( OH ) 2D3 degradation through enhancement of 24-hydroxylase mRNA levels and activity .
normal human pulmonary alveolar macrophages ( pam ) are less sensitive to 1 , 25 ( oh ) 2d3 than pbm , despite similar vitamin d receptor content ; however , both pbm and pam respond to exogenous 1 , 25- ( oh ) 2d3 by inhibiting 1 , 25 ( oh ) 2d3 synthesis and inducing 1 , 25 ( oh ) 2d3 degradation through enhancement of 24-hydroxylase mrna levels and activity .
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