Most interestingly , the N-terminal SH2 domain had an inhibitory effect , whereas a mutant p85 containing only the two SH2 domains enhanced basal NFAT activity in a Ras -dependent manner .
most interestingly , the n-terminal sh2 domain had an inhibitory effect , whereas a mutant p85 containing only the two sh2 domains enhanced basal nfat activity in a ras -dependent manner .
O O O O B-protein_domain_or_region I-protein_domain_or_region I-protein_domain_or_region O O O O O O O B-protein_subunit B-protein_subunit O O O B-protein_domain_or_region I-protein_domain_or_region I-protein_domain_or_region O O B-protein_family_or_group O O O B-protein_molecule O O O