Virus production occurred with slightly delayed kinetics for viruses containing combined mutations in the AP-1 ( III ) , AP3-L , and DBF sites and in the AP3-L and DBF-sites , whereas viruses mutated in the AP-1 ( I , II , III ) and AP3-L sites and in the AP-1 ( I , II , III ) , AP3-L , and DBF sites exhibited a severely defective replicative phenotype .
virus production occurred with slightly delayed kinetics for viruses containing combined mutations in the ap-1 ( iii ) , ap3-l , and dbf sites and in the ap3-l and dbf-sites , whereas viruses mutated in the ap-1 ( i , ii , iii ) and ap3-l sites and in the ap-1 ( i , ii , iii ) , ap3-l , and dbf sites exhibited a severely defective replicative phenotype .
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