Switching is hampered by CD30 coengagement , possibly through interference with the CD40 -mediated NF-kappaB -dependent transcriptional activation of downstream C ( H ) genes .
switching is hampered by cd30 coengagement , possibly through interference with the cd40 -mediated nf-kappab -dependent transcriptional activation of downstream c ( h ) genes .
O O O O B-protein_molecule O O O O O O O B-protein_molecule O B-protein_complex O O O O B-DNA_family_or_group I-DNA_family_or_group I-DNA_family_or_group I-DNA_family_or_group I-DNA_family_or_group I-DNA_family_or_group O