We hypothesized that activation of the protein kinase A signaling pathway may inhibit NF-kappaB -mediated transcription by phosphorylating proteins , such as cAMP response element-binding protein ( CREB ) , which compete for limiting amounts of the coactivator CBP .
we hypothesized that activation of the protein kinase a signaling pathway may inhibit nf-kappab -mediated transcription by phosphorylating proteins , such as camp response element-binding protein ( creb ) , which compete for limiting amounts of the coactivator cbp .
O O O O O O B-protein_molecule I-protein_molecule I-protein_molecule O O O O B-protein_complex O O O O O O O O B-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule O B-protein_molecule O O O O O O O O O O B-protein_molecule O