We took advantage of our monoclonal model of germinal center B cell differentiation , IgM+ IgD+ CL-01 cells , to define the role of the I gamma 3 evolutionarily conserved sequence ( ECS ) in the germline transcriptional activation of the human C gamma 3 gene .
we took advantage of our monoclonal model of germinal center b cell differentiation , igm+ igd+ cl-01 cells , to define the role of the i gamma 3 evolutionarily conserved sequence ( ecs ) in the germline transcriptional activation of the human c gamma 3 gene .
O O O O O O O O B-cell_type I-cell_type I-cell_type I-cell_type O O B-cell_line I-cell_line I-cell_line I-cell_line O O O O O O O B-protein_molecule I-protein_molecule I-protein_molecule B-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region O B-DNA_domain_or_region O O O B-DNA_domain_or_region O O O O B-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region O