Pretreatment with the broad serine /threonine kinase inhibitor staurosporine partly blocked the calyculin A -induced STAT3 phosphorylation , whereas inhibitors of serine /threonine kinases , such as mitogen-activated protein kinase-1 extracellular-regulated kinase-kinase , mitogen-activated protein p38 kinase , and phosphatidylinositol 3-kinase , did not .
pretreatment with the broad serine /threonine kinase inhibitor staurosporine partly blocked the calyculin a -induced stat3 phosphorylation , whereas inhibitors of serine /threonine kinases , such as mitogen-activated protein kinase-1 extracellular-regulated kinase-kinase , mitogen-activated protein p38 kinase , and phosphatidylinositol 3-kinase , did not .
O O O O B-amino_acid_monomer B-amino_acid_monomer O O B-other_organic_compound O O O B-protein_molecule I-protein_molecule O B-protein_molecule O O O O O B-amino_acid_monomer B-amino_acid_monomer O O O O B-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule O B-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule O O B-protein_molecule I-protein_molecule O O O O