In order to further understand the apparent glucocorticoid resistance in major depressive disorder , circadian variation in cortisol concentration , dexamethasone suppression and glucocorticoid receptor binding in mononuclear leukocytes , polymorphonuclear leukocytes and cultured skin fibroblasts were measured in rigidly defined major depressive disorder patients and non-depressed psychiatric controls .
in order to further understand the apparent glucocorticoid resistance in major depressive disorder , circadian variation in cortisol concentration , dexamethasone suppression and glucocorticoid receptor binding in mononuclear leukocytes , polymorphonuclear leukocytes and cultured skin fibroblasts were measured in rigidly defined major depressive disorder patients and non-depressed psychiatric controls .
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