Mutation of the major Sp1 binding site ( -110 bp ) decreased tissue-specific promoter activity , and these results , together with transactivation experiments , demonstrate that Sp1 plays a critical role in the tissue-specific expression of CD14 in monocytic cells .
mutation of the major sp1 binding site ( -110 bp ) decreased tissue-specific promoter activity , and these results , together with transactivation experiments , demonstrate that sp1 plays a critical role in the tissue-specific expression of cd14 in monocytic cells .
O O O B-DNA_domain_or_region B-protein_molecule O O O B-DNA_domain_or_region I-DNA_domain_or_region O O O O O O O O O O O O B-other_name I-other_name O O O B-protein_molecule O O O O O O O O O B-protein_molecule O B-cell_type I-cell_type O