Phosphorylation of the retinoblastoma protein by cyclin-dependent kinases 4 and 6 prevents its interaction with the transcription factor E2F , which subsequently promotes the expression of S phase regulated genes , such as thymidine kinase .
phosphorylation of the retinoblastoma protein by cyclin-dependent kinases 4 and 6 prevents its interaction with the transcription factor e2f , which subsequently promotes the expression of s phase regulated genes , such as thymidine kinase .
O O O B-protein_family_or_group I-protein_family_or_group O O O O O O O O O O O B-protein_family_or_group I-protein_family_or_group B-protein_molecule O O O O O O O B-other_name I-other_name O O O O O B-protein_family_or_group I-protein_family_or_group O