Mature human lymphocytes are unique targets of 1 alpha , 25-dihydroxyvitamin D3 ( 1 alpha , 25 ( OH ) 2D3 ) in that vitamin D receptors ( VDR ) are not constitutively expressed , and specific cellular activation signals are required for both the up-regulation of VDR and establishment of reactivity to the lipophilic ligand .
mature human lymphocytes are unique targets of 1 alpha , 25-dihydroxyvitamin d3 ( 1 alpha , 25 ( oh ) 2d3 ) in that vitamin d receptors ( vdr ) are not constitutively expressed , and specific cellular activation signals are required for both the up-regulation of vdr and establishment of reactivity to the lipophilic ligand .
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