We conclude that glucocorticoids differentially modulate TNFalpha and IL-10 secretion by human monocytes in a LPS dose-dependent fashion and that the sensitivity of these cells to glucocorticoids is altered by TNFalpha or IL-10 pretreatment ; TNFalpha blocks their effects , whereas IL-10 acts synergistically with glucocorticoids .
we conclude that glucocorticoids differentially modulate tnfalpha and il-10 secretion by human monocytes in a lps dose-dependent fashion and that the sensitivity of these cells to glucocorticoids is altered by tnfalpha or il-10 pretreatment ; tnfalpha blocks their effects , whereas il-10 acts synergistically with glucocorticoids .
O O O B-lipid O O B-protein_molecule O B-protein_molecule O O B-cell_type I-cell_type O O B-lipid O O O O O O O O O O B-lipid O O O B-protein_molecule O B-protein_molecule O O B-protein_molecule O O O O O B-protein_molecule O O O B-lipid O