NB4 cells pulse-exposed ( 30 minutes ) to all-trans retinoic acid ( ATRA ) , washed , and cultured ( 3 days ) with either dimethylsulfoxide ( DMSO ) or hexamethylene bisacetamide ( HMBA ) had a prominent increase in levels of C/EBP epsilon mRNA and an increase in granulocytic differentiation , but exposure to either DMSO or HMBA alone had no effect on base levels of C/EBP epsilon and did not induce differentiation .
nb4 cells pulse-exposed ( 30 minutes ) to all-trans retinoic acid ( atra ) , washed , and cultured ( 3 days ) with either dimethylsulfoxide ( dmso ) or hexamethylene bisacetamide ( hmba ) had a prominent increase in levels of c/ebp epsilon mrna and an increase in granulocytic differentiation , but exposure to either dmso or hmba alone had no effect on base levels of c/ebp epsilon and did not induce differentiation .
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