In CsA -treated leukocytes stimulated by calcium ionophore , the degree of reduction in CN activity was accompanied by a similar degree of inhibition of each event tested : dephosphorylation of nuclear factor of activated T cell proteins , nuclear DNA binding , activation of a transfected reporter gene construct , IFN-gamma and IL-2 mRNA accumulation , and IFN-gamma production .
in csa -treated leukocytes stimulated by calcium ionophore , the degree of reduction in cn activity was accompanied by a similar degree of inhibition of each event tested : dephosphorylation of nuclear factor of activated t cell proteins , nuclear dna binding , activation of a transfected reporter gene construct , ifn-gamma and il-2 mrna accumulation , and ifn-gamma production .
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