Small apolar substitutions ( 11 alpha-methyl , 11 alpha-fluoromethyl ) did not markedly decrease the affinity for the vitamin D receptor , but larger ( 11 alpha-chloromethyl or 11 alpha- or 11 beta-phenyl ) or more polar substitutions ( 11 alpha-hydroxymethyl , 11 alpha- ( 2-hydroxyethyl ] decreased the affinity to less than 5% of that of 1 alpha , 25-OH ) 2D3 .
small apolar substitutions ( 11 alpha-methyl , 11 alpha-fluoromethyl ) did not markedly decrease the affinity for the vitamin d receptor , but larger ( 11 alpha-chloromethyl or 11 alpha- or 11 beta-phenyl ) or more polar substitutions ( 11 alpha-hydroxymethyl , 11 alpha- ( 2-hydroxyethyl ] decreased the affinity to less than 5% of that of 1 alpha , 25-oh ) 2d3 .
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