Unlike the proposed role of Cbl as a negative regulator , our results suggest that the Cbl homologue Cbl -b has a positive role in T-cell signaling , most likely via a direct interaction with the upstream kinase Zap-70 .
unlike the proposed role of cbl as a negative regulator , our results suggest that the cbl homologue cbl -b has a positive role in t-cell signaling , most likely via a direct interaction with the upstream kinase zap-70 .
O O O O O B-protein_molecule O O O O O O O O O O B-protein_molecule O B-protein_molecule O O O O O O B-other_name I-other_name O O O O O O O O O B-protein_family_or_group I-protein_family_or_group B-protein_molecule O