Two explanations for hyporesponsiveness of the human iNOS promoter to LPS +/- IFN-gamma were found : ( 1 ) multiple inactivating nucleotide substitutions in the human counterpart of the enhancer element that has been shown to regulate LPS / IFN-gamma induced expression of the mouse iNOS gene ; and ( 2 ) and absence of one or more nuclear factors in human macrophages ( e . g . , an LPS -inducible nuclear factor-kappa B/ Rel complex ) , that is ( are ) required for maximal expression of the gene .
two explanations for hyporesponsiveness of the human inos promoter to lps +/- ifn-gamma were found : ( 1 ) multiple inactivating nucleotide substitutions in the human counterpart of the enhancer element that has been shown to regulate lps / ifn-gamma induced expression of the mouse inos gene ; and ( 2 ) and absence of one or more nuclear factors in human macrophages ( e . g . , an lps -inducible nuclear factor-kappa b/ rel complex ) , that is ( are ) required for maximal expression of the gene .
O O O O O O B-DNA_domain_or_region B-protein_molecule O O B-lipid O B-protein_molecule O O O O O O O O O O O O O O O O B-DNA_domain_or_region I-DNA_domain_or_region O O O O O O B-lipid O B-protein_molecule O O O O B-DNA_domain_or_region B-protein_molecule O O O O O O O O O O O O B-protein_family_or_group I-protein_family_or_group O B-cell_type I-cell_type O O O O O O O B-lipid O O O O B-protein_family_or_group O O O O O O O O O O O O O O O O