Three mutants ( -201/-184 NXS , -165/-148 NXS , and -147/-130 NXS ) had effects on viral replication that were much more severe than the effects predicted from their performance in transfection analyses , and the effects of two LS mutations ( -201/-184 NXS and -183/-166 NXS ) were not predicted by their effects in transfection .
three mutants ( -201/-184 nxs , -165/-148 nxs , and -147/-130 nxs ) had effects on viral replication that were much more severe than the effects predicted from their performance in transfection analyses , and the effects of two ls mutations ( -201/-184 nxs and -183/-166 nxs ) were not predicted by their effects in transfection .
O O O B-virus I-virus O B-virus I-virus O O B-virus I-virus O O O O B-other_name I-other_name O O O O O O O O O O O O O B-other_name I-other_name O O O O O O B-other_name I-other_name O B-virus I-virus O B-virus I-virus O O O O O O O O O O