Phosphoinositide 3-kinase ( PI 3-kinase ) is activated by a diverse set of receptors that determine T-cell function , including the T-cell antigen receptor ( TCR ) , the costimulatory receptor CD28 , and negative regulators of T-cell activation such as CTLA-4 .
phosphoinositide 3-kinase ( pi 3-kinase ) is activated by a diverse set of receptors that determine t-cell function , including the t-cell antigen receptor ( tcr ) , the costimulatory receptor cd28 , and negative regulators of t-cell activation such as ctla-4 .
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