In three unrelated Japanese children with combined pituitary hormone deficiency , we identified three point mutations in the Pit-1 gene , Pro24Leu , Arg143Gln , and Arg271Trp , located on the major transactivation region , POU-specific domain , and POU-homeodomain , respectively .
in three unrelated japanese children with combined pituitary hormone deficiency , we identified three point mutations in the pit-1 gene , pro24leu , arg143gln , and arg271trp , located on the major transactivation region , pou-specific domain , and pou-homeodomain , respectively .
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