We show that a constitutively active mutant of human Toll transfected into human cell lines can induce the activation of NF-kappaB and the expression of NF-kappaB -controlled genes for the inflammatory cytokines IL-1 , IL-6 and IL-8 , as well as the expression of the co-stimulatory molecule B7 . 1 , which is required for the activation of naive T cells .
we show that a constitutively active mutant of human toll transfected into human cell lines can induce the activation of nf-kappab and the expression of nf-kappab -controlled genes for the inflammatory cytokines il-1 , il-6 and il-8 , as well as the expression of the co-stimulatory molecule b7 . 1 , which is required for the activation of naive t cells .
O O O O O O O O B-protein_molecule B-protein_molecule O O O O O O O O O O B-protein_complex O O O O B-protein_complex O O O O B-protein_family_or_group B-protein_family_or_group B-protein_molecule O B-protein_molecule O B-protein_molecule O O O O O O O O B-protein_family_or_group I-protein_family_or_group B-protein_molecule I-protein_molecule I-protein_molecule O O O O O O O O B-cell_type B-cell_type I-cell_type O