Previous studies have shown that retinoic acid ( RA ) , similar to tumor necrosis factor-alpha ( TNF-alpha ) , can act as a bifunctional regulator of the growth of bone marrow progenitors , in that it can stimulate granulocyte-macrophage colony-stimulating factor ( GM-CSF ) - or interleukin-3 ( IL-3 ) - induced GM colony formation , but potently inhibit G-CSF -induced growth .
previous studies have shown that retinoic acid ( ra ) , similar to tumor necrosis factor-alpha ( tnf-alpha ) , can act as a bifunctional regulator of the growth of bone marrow progenitors , in that it can stimulate granulocyte-macrophage colony-stimulating factor ( gm-csf ) - or interleukin-3 ( il-3 ) - induced gm colony formation , but potently inhibit g-csf -induced growth .
O O O O O B-other_organic_compound I-other_organic_compound O B-other_organic_compound O O O O B-protein_molecule I-protein_molecule I-protein_molecule O B-protein_molecule O O O O O O O O O O O O B-tissue I-tissue O O O O O O O O O O O O O O O O O O O O O O O O O O O O B-protein_molecule O O O