An inhibitory , "dominant-negative , " form of the calcineurin catalytic ( A ) subunit was prepared , which lacks the calmodulin -binding domain , autoinhibitory domain and most of its catalytic core but possesses the regulatory ( B ) subunit binding domain .
an inhibitory , "dominant-negative , " form of the calcineurin catalytic ( a ) subunit was prepared , which lacks the calmodulin -binding domain , autoinhibitory domain and most of its catalytic core but possesses the regulatory ( b ) subunit binding domain .
O O O O O O O O O B-protein_molecule O O O O O O O O O O O B-protein_molecule O O O B-protein_domain_or_region I-protein_domain_or_region O O O O O O O O O B-protein_subunit I-protein_subunit I-protein_subunit I-protein_subunit I-protein_subunit O O O