We propose that mutations of MDS1/EVI1 either by gene truncation resulting in the transcription repressor EVI1 or by gene fusion to AML1 lead to an altered cellular response to growth and differentiation factors that could result in leukemic transformation .
we propose that mutations of mds1/evi1 either by gene truncation resulting in the transcription repressor evi1 or by gene fusion to aml1 lead to an altered cellular response to growth and differentiation factors that could result in leukemic transformation .
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