A modest ( 20-50% ) reduction in TNF promoter activity was observed with the AP-2 site mutation .
a modest ( 20-50% ) reduction in tnf promoter activity was observed with the ap-2 site mutation .
O O O O O O O B-DNA_domain_or_region I-DNA_domain_or_region O O O O O B-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region O