Thus HIV-1 gp41 -induced IL-10 up-regulation in monocytes may not involve NF-kappaB , MAPK , or PI 3-kinase activation , but rather may operate through activation of adenylate cyclase and pertussis-toxin-sensitive Gi/Go protein to effect p70 ( S6 ) -kinase activation .
thus hiv-1 gp41 -induced il-10 up-regulation in monocytes may not involve nf-kappab , mapk , or pi 3-kinase activation , but rather may operate through activation of adenylate cyclase and pertussis-toxin-sensitive gi/go protein to effect p70 ( s6 ) -kinase activation .
O B-virus B-protein_molecule O B-protein_molecule O O B-cell_type O O O B-protein_complex O B-protein_family_or_group O O B-protein_molecule I-protein_molecule O O O O O O O O O B-protein_complex I-protein_complex O B-protein_molecule I-protein_molecule I-protein_molecule O O B-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule O O