Moreover , since inhibition of protein synthesis leads to accumulation of I kappa B alpha /MAD-3 mRNA without stimulating I kappa B alpha /MAD-3 gene transcription , we suggest that low cytoplasmic levels of I kappa B alpha /MAD-3 mRNA are maintained by a translation-dependent degradation mechanism .
moreover , since inhibition of protein synthesis leads to accumulation of i kappa b alpha /mad-3 mrna without stimulating i kappa b alpha /mad-3 gene transcription , we suggest that low cytoplasmic levels of i kappa b alpha /mad-3 mrna are maintained by a translation-dependent degradation mechanism .
O O O O O O O O O O O B-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule O O O O B-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule O O O O O O O O B-other_name I-other_name O B-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule O O O O O O B-other_name I-other_name I-other_name O