In a previous study , we demonstrated that bufalin , which is an active principle of Chinese medicine , chan'su , caused apoptosis in human leukemia U937 cells by anomalous activation of mitogen-activated protein kinase ( MAPK ) via the signaling pathway of Ras , Raf-1 , and MAPK kinase-1 .
in a previous study , we demonstrated that bufalin , which is an active principle of chinese medicine , chan'su , caused apoptosis in human leukemia u937 cells by anomalous activation of mitogen-activated protein kinase ( mapk ) via the signaling pathway of ras , raf-1 , and mapk kinase-1 .
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