It is demonstrated here with human T lymphocytes and monocytes that different stimuli , including tumor necrosis factor alpha and phorbol 12-myristate 13-acetate , cause rapid degradation of I kappa B-alpha , with concomitant activation of NF-kappa B , followed by a dramatic increase in I kappa B-alpha mRNA and protein synthesis .
it is demonstrated here with human t lymphocytes and monocytes that different stimuli , including tumor necrosis factor alpha and phorbol 12-myristate 13-acetate , cause rapid degradation of i kappa b-alpha , with concomitant activation of nf-kappa b , followed by a dramatic increase in i kappa b-alpha mrna and protein synthesis .
O O O O O B-cell_type B-cell_type I-cell_type O B-cell_type O O O O O B-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule O B-other_organic_compound I-other_organic_compound I-other_organic_compound O O O O O B-protein_molecule I-protein_molecule I-protein_molecule O O O O O B-protein_molecule I-protein_molecule O O O O O O O B-protein_molecule I-protein_molecule I-protein_molecule O O O O O