We find that the dissociation constant of rapamycin to the FK506 binding protein FKBP ( Kd = 0 . 2 nM ) is close to the dissociation constant of FK506 to FKBP ( Kd = 0 . 4 nM ) and to their effective biologic inhibitory concentrations .
we find that the dissociation constant of rapamycin to the fk506 binding protein fkbp ( kd = 0 . 2 nm ) is close to the dissociation constant of fk506 to fkbp ( kd = 0 . 4 nm ) and to their effective biologic inhibitory concentrations .
O O O O O O O B-other_organic_compound O O B-other_organic_compound O O B-protein_molecule O O O O O O O O O O O O O O O B-other_organic_compound O B-protein_molecule O O O O O O O O O O O O B-other_name I-other_name I-other_name O