Here , Stuart Schreiber and Gerald Crabtree review recent findings that indicate CsA and FK506 operate as prodrugs : they bind endogenous intracellular receptors , the immunophilins , and the resulting complex targets the protein phosphatase , calcineurin , to exert the immunosuppressive effect .
here , stuart schreiber and gerald crabtree review recent findings that indicate csa and fk506 operate as prodrugs : they bind endogenous intracellular receptors , the immunophilins , and the resulting complex targets the protein phosphatase , calcineurin , to exert the immunosuppressive effect .
O O O O O O O O O O O O B-other_organic_compound O B-other_organic_compound O O B-other_name O O O B-protein_family_or_group I-protein_family_or_group I-protein_family_or_group O O B-protein_family_or_group O O O O O O O B-protein_family_or_group I-protein_family_or_group I-protein_family_or_group B-protein_family_or_group O O O O B-other_name I-other_name O