Transfection of a cDNA containing the human CIITA coding sequence under the control of an heterologous promoter restores expression of human MHC class II genes in the hybrids and is responsible for de novo expression of mouse MHC class II genes in both the mouse plasmacytoma cell line and the hybrids .
transfection of a cdna containing the human ciita coding sequence under the control of an heterologous promoter restores expression of human mhc class ii genes in the hybrids and is responsible for de novo expression of mouse mhc class ii genes in both the mouse plasmacytoma cell line and the hybrids .
O O O O O O B-DNA_domain_or_region B-protein_molecule O O O O O O O B-DNA_domain_or_region I-DNA_domain_or_region O O O B-DNA_family_or_group I-DNA_family_or_group I-DNA_family_or_group I-DNA_family_or_group I-DNA_family_or_group O O O O O O O O O O O B-DNA_family_or_group I-DNA_family_or_group I-DNA_family_or_group I-DNA_family_or_group I-DNA_family_or_group O O O B-cell_line I-cell_line I-cell_line I-cell_line O O B-cell_line O