Following neutrophil stimulation with proinflammatory agonists ( such as lipopolysaccharide [ LPS ] , tumor necrosis factor-alpha [ TNF-alpha ] , and fMet-Leu-Phe ) that induce the production of cytokines and chemokines in these cells , NF-kappaB /Rel proteins translocated to nuclear fractions , resulting in a transient induction of NF-kappaB DNA binding activity , as determined in gel mobility shift assays .
following neutrophil stimulation with proinflammatory agonists ( such as lipopolysaccharide [ lps ] , tumor necrosis factor-alpha [ tnf-alpha ] , and fmet-leu-phe ) that induce the production of cytokines and chemokines in these cells , nf-kappab /rel proteins translocated to nuclear fractions , resulting in a transient induction of nf-kappab dna binding activity , as determined in gel mobility shift assays .
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