Here we report that binding of human IL-2 to its binding site leads to transcriptional activation of the macrophage CSF ( M-CSF ) gene in Mo resulting in accumulation of M-CSF mRNA and subsequent release of bioactive M-CSF protein as demonstrated by ELISA and inhibition of IL-2 induced release of an activity-stimulating growth of monocyte-type colonies by a neutralizing anti-M-CSF antibody .
here we report that binding of human il-2 to its binding site leads to transcriptional activation of the macrophage csf ( m-csf ) gene in mo resulting in accumulation of m-csf mrna and subsequent release of bioactive m-csf protein as demonstrated by elisa and inhibition of il-2 induced release of an activity-stimulating growth of monocyte-type colonies by a neutralizing anti-m-csf antibody .
O O O O O O B-protein_molecule I-protein_molecule O O O O O O O O O O B-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region B-protein_molecule O O O B-cell_type O O O O B-protein_molecule O O O O O O B-protein_molecule I-protein_molecule O O O B-other_name O O O B-protein_molecule O O O O O O O B-cell_line I-cell_line O O O B-protein_molecule I-protein_molecule O