We report here that PML is expressed at low levels or not expressed in normal circulating human monocytes , lymphocytes , and polymorphonucleate cells , but is markedly induced by interferon ; that PML and PML/RAR alpha expression is augmented by interferon in the NB4 APL cell line , which carries the t ( 15 ; 17 ) , and in APL blasts from patients ; that interferon inhibits growth and survival of NB4 APL cells in cooperation with RA ; that interferons alone have minimal maturation effect on NB4 cells ; and , finally , that interferon gamma , but not alpha or beta , induces maturation and growth suppression of NB4 cells with de novo retinoid resistance , and partially restores RA response .
we report here that pml is expressed at low levels or not expressed in normal circulating human monocytes , lymphocytes , and polymorphonucleate cells , but is markedly induced by interferon ; that pml and pml/rar alpha expression is augmented by interferon in the nb4 apl cell line , which carries the t ( 15 ; 17 ) , and in apl blasts from patients ; that interferon inhibits growth and survival of nb4 apl cells in cooperation with ra ; that interferons alone have minimal maturation effect on nb4 cells ; and , finally , that interferon gamma , but not alpha or beta , induces maturation and growth suppression of nb4 cells with de novo retinoid resistance , and partially restores ra response .
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