Thus , ligation of CD28 with either CD80 or CD86 leads to shared early signal transduction events such as the tyrosine phosphorylation of CBL and VAV , to NFAT -mediated transcriptional activation , and to the costimulation of interleukin-2 and granulocyte-macrophage colony-stimulating factor production .
thus , ligation of cd28 with either cd80 or cd86 leads to shared early signal transduction events such as the tyrosine phosphorylation of cbl and vav , to nfat -mediated transcriptional activation , and to the costimulation of interleukin-2 and granulocyte-macrophage colony-stimulating factor production .
O O O O B-protein_molecule O O B-protein_molecule O B-protein_molecule O O O O O O O O O O B-amino_acid_monomer O O B-protein_molecule O B-protein_molecule O O B-protein_family_or_group O O O O O O O O O B-protein_molecule O B-protein_molecule I-protein_molecule I-protein_molecule O O