Unexpectedly , we observed that an RXR -specific , rather than an RAR -specific , agonist induces terminal granulocytic differentiation of MPRO promyelocytes , and this differentiation is associated with activation of DNA response elements corresponding to RAR-RXR heterodimers rather than RXR-RXR homodimers .
unexpectedly , we observed that an rxr -specific , rather than an rar -specific , agonist induces terminal granulocytic differentiation of mpro promyelocytes , and this differentiation is associated with activation of dna response elements corresponding to rar-rxr heterodimers rather than rxr-rxr homodimers .
O O O O O O B-protein_molecule O O O O O B-protein_family_or_group O O O O B-other_name I-other_name I-other_name O B-cell_type I-cell_type O O O O O O O O O B-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region O O B-protein_complex I-protein_complex O O B-protein_complex O O