To examine the molecular basis of constitutive NF-kappaB DNA-binding activity in HIV1 -infected cells , we analyzed the phosphorylation and turnover of IkappaBalpha protein , the activity of the double-stranded RNA-dependent protein kinase ( PKR ) and the intracellular levels of NF-kappaB subunits in the PLB-985 and U937 myeloid cell models .
to examine the molecular basis of constitutive nf-kappab dna-binding activity in hiv1 -infected cells , we analyzed the phosphorylation and turnover of ikappabalpha protein , the activity of the double-stranded rna-dependent protein kinase ( pkr ) and the intracellular levels of nf-kappab subunits in the plb-985 and u937 myeloid cell models .
O O O O O O O B-protein_complex O O O B-cell_type I-cell_type I-cell_type O O O O O O O O B-protein_molecule O O O O O O B-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule O B-protein_molecule O O O O O O B-protein_complex O O O B-cell_line O B-cell_line I-cell_line I-cell_line I-cell_line O