Nonetheless , a membrane-proximal region of human IL-2R beta ( Asn240-Leu335 ) was critical for JAK3 activation , and the amount of JAK3 present in activated IL-2 receptor complexes increased with time , suggesting that stabilization of JAK3 binding to the receptor complex relies on both IL-2R beta and IL-2R gamma .
nonetheless , a membrane-proximal region of human il-2r beta ( asn240-leu335 ) was critical for jak3 activation , and the amount of jak3 present in activated il-2 receptor complexes increased with time , suggesting that stabilization of jak3 binding to the receptor complex relies on both il-2r beta and il-2r gamma .
O O O B-protein_domain_or_region I-protein_domain_or_region O O B-protein_molecule I-protein_molecule O B-protein_domain_or_region O O O O B-protein_molecule O O O O O O B-protein_molecule O O O B-protein_molecule O O O O O O O O O O B-protein_molecule O O O B-protein_complex I-protein_complex O O O B-protein_molecule I-protein_molecule O B-protein_molecule I-protein_molecule O