Mutation of this motif almost completely , and specifically , abolished the binding of two low-mobility complexes and led to a 95% decrease of constitutive transcriptional activation of a reporter construct IL-1beta ( -170/+108 ) .
mutation of this motif almost completely , and specifically , abolished the binding of two low-mobility complexes and led to a 95% decrease of constitutive transcriptional activation of a reporter construct il-1beta ( -170/+108 ) .
O O O O O O O O O O O O O O O B-protein_complex I-protein_complex O O O O O O O O B-other_name I-other_name O O O O B-protein_molecule O O O O