The mutant , containing a serine -to- alanine substitution in the DNA-binding domain of the protein , bound to several known ZEBRA -binding sites and activated transcription from reporters bearing known ZEBRA -responsive promoters but did not disrupt latency in EBV -infected cell lines .
the mutant , containing a serine -to- alanine substitution in the dna-binding domain of the protein , bound to several known zebra -binding sites and activated transcription from reporters bearing known zebra -responsive promoters but did not disrupt latency in ebv -infected cell lines .
O O O O O B-amino_acid_monomer O B-amino_acid_monomer O O O B-protein_domain_or_region I-protein_domain_or_region O O O O O O O O B-protein_molecule O O O O B-other_name O O O O B-protein_molecule O O O O O O O O B-virus O O O O