Our results suggest that the bulk of protein-DNA interactions that underlies the developmental control of globin genes takes place in the gamma- and beta- globin gene promoters , and that GT motifs of the beta-globin locus LCR may play a role in the developmental regulation of human beta-globin gene expression , perhaps by increasing the probability of interaction of the LCR holocomplex with the fetal or the adult globin gene .
our results suggest that the bulk of protein-dna interactions that underlies the developmental control of globin genes takes place in the gamma- and beta- globin gene promoters , and that gt motifs of the beta-globin locus lcr may play a role in the developmental regulation of human beta-globin gene expression , perhaps by increasing the probability of interaction of the lcr holocomplex with the fetal or the adult globin gene .
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