Given the reported long-range cis-inactivating effect of the XIST gene in early embryonic development and the lack of requirement of X-chromosome-specific elements for propagating the inactive state , there exists the possibility of cis inactivation of autosomal material after de novo translocation to an inactive X chromosome ( Xi ) in differentiated cells .
given the reported long-range cis-inactivating effect of the xist gene in early embryonic development and the lack of requirement of x-chromosome-specific elements for propagating the inactive state , there exists the possibility of cis inactivation of autosomal material after de novo translocation to an inactive x chromosome ( xi ) in differentiated cells .
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