Active Raf-1 phosphorylates and activates the mitogen-activated protein ( MAP ) kinase /extracellular signal-regulated kinase kinase 1 ( MEK1 ) , which in turn phosphorylates and activates the MAP kinases/extracellular signal regulated kinases , ERK1 and ERK2 .
active raf-1 phosphorylates and activates the mitogen-activated protein ( map ) kinase /extracellular signal-regulated kinase kinase 1 ( mek1 ) , which in turn phosphorylates and activates the map kinases/extracellular signal regulated kinases , erk1 and erk2 .
O B-protein_molecule O O O O B-protein_family_or_group I-protein_family_or_group I-protein_family_or_group I-protein_family_or_group I-protein_family_or_group I-protein_family_or_group O O O O O O B-protein_molecule O O O O O O O O O B-protein_family_or_group I-protein_family_or_group I-protein_family_or_group I-protein_family_or_group I-protein_family_or_group O B-protein_molecule O B-protein_molecule O