Site-directed mutagenesis demonstrated that the two NF-IL-6 motifs could be independently activated by LAM , LPS , or TNF-alpha and that they acted in an orientation-independent manner .
site-directed mutagenesis demonstrated that the two nf-il-6 motifs could be independently activated by lam , lps , or tnf-alpha and that they acted in an orientation-independent manner .
O O O O O O B-DNA_domain_or_region I-DNA_domain_or_region O O O O O B-lipid O B-lipid O O B-protein_molecule O O O O O O O O O