To overcome this problem , we have exploited the observation that activated human T cell blasts can be stimulated via the CD28 surface molecule in the absence of antigenic challenge ; thus , we have been able to observe the response of normal T cells to CD28 activation in isolation .
to overcome this problem , we have exploited the observation that activated human t cell blasts can be stimulated via the cd28 surface molecule in the absence of antigenic challenge ; thus , we have been able to observe the response of normal t cells to cd28 activation in isolation .
O O O O O O O O O O O O B-cell_type I-cell_type I-cell_type I-cell_type O O O O O B-protein_molecule O O O O O O B-other_name I-other_name O O O O O O O O O O O O B-cell_type I-cell_type I-cell_type O B-protein_molecule O O O O