Efforts to pinpoint the exact site of action and specificity of HePTP in the signaling cascade revealed that HePTP acts directly on the mitogen-activated protein ( MAP ) kinases Erk 1 and 2 and consequently reduces the magnitude and duration of their catalytic activation in intact T cells .
efforts to pinpoint the exact site of action and specificity of heptp in the signaling cascade revealed that heptp acts directly on the mitogen-activated protein ( map ) kinases erk 1 and 2 and consequently reduces the magnitude and duration of their catalytic activation in intact t cells .
O O O O O O O O O O O B-protein_molecule O O O O O O B-protein_molecule O O O O B-protein_family_or_group I-protein_family_or_group I-protein_family_or_group I-protein_family_or_group I-protein_family_or_group I-protein_family_or_group O O O O O O O O O O O O O O O O B-cell_type I-cell_type I-cell_type O