In conclusion , three different cell-specific pathways lead to NF-kappaB activation by IL-1beta : a pathway dependent on ROI production by 5-LOX in lymphoid cells , an ROI- and 5-LOX -independent pathway in epithelial cells , and a pathway requiring ROI production by NADPH oxidase in monocytic cells .
in conclusion , three different cell-specific pathways lead to nf-kappab activation by il-1beta : a pathway dependent on roi production by 5-lox in lymphoid cells , an roi- and 5-lox -independent pathway in epithelial cells , and a pathway requiring roi production by nadph oxidase in monocytic cells .
O O O O O B-other_name I-other_name O O B-protein_complex O O B-protein_molecule O O O O O B-other_name I-other_name O B-protein_molecule O B-cell_type I-cell_type O O B-other_name I-other_name B-protein_molecule O O O B-cell_type I-cell_type O O O O O O O O B-other_organic_compound O O B-cell_type I-cell_type O