Two pp56 ( lck ) mutants lacking either the entire catalytic domain or the entire NH2 regulatory domain were generated , and their abilities to trigger transactivation of the TCR-regulated nuclear factor of activated T cells ( NF-AT ) region of the IL-2 promoter were compared .
two pp56 ( lck ) mutants lacking either the entire catalytic domain or the entire nh2 regulatory domain were generated , and their abilities to trigger transactivation of the tcr-regulated nuclear factor of activated t cells ( nf-at ) region of the il-2 promoter were compared .
O B-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule O O O O O B-protein_domain_or_region I-protein_domain_or_region O O O B-protein_molecule B-protein_domain_or_region I-protein_domain_or_region O O O O O O O O O O O B-protein_family_or_group I-protein_family_or_group I-protein_family_or_group O B-cell_type I-cell_type I-cell_type O B-protein_molecule O O O O B-DNA_domain_or_region I-DNA_domain_or_region O O O