Upon ligand-induced Mpl homodimerization , the major signaling events for proliferation are mediated through the JAK2 /STAT5 pathway , while differentiation might occur through a prolonged activation of the MAPK pathway .
upon ligand-induced mpl homodimerization , the major signaling events for proliferation are mediated through the jak2 /stat5 pathway , while differentiation might occur through a prolonged activation of the mapk pathway .
O O B-other_name I-other_name O O O O O O O O O O O B-protein_molecule B-protein_molecule O O O O O O O O O O O O B-protein_family_or_group O O