When tested for its ability to block calcineurin -dependent signaling in Jurkat cells , expression of this "B-subunit knock-out" ( BKO ) construct suppressed reporter gene activity driven by NF-AT , the pivotal promoter element for interleukin ( IL ) -2 gene induction .
when tested for its ability to block calcineurin -dependent signaling in jurkat cells , expression of this "b-subunit knock-out" ( bko ) construct suppressed reporter gene activity driven by nf-at , the pivotal promoter element for interleukin ( il ) -2 gene induction .
O O O O O O O B-protein_molecule O O O O O O O O O B-DNA_molecule I-DNA_molecule I-DNA_molecule I-DNA_molecule I-DNA_molecule I-DNA_molecule O B-DNA_family_or_group I-DNA_family_or_group O O O B-protein_molecule O O O B-DNA_domain_or_region I-DNA_domain_or_region O B-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule O O O