Among upstream signaling molecules of ERK , Shc was constitutively associated with Grb2 and was not tyrosine -phosphorylated by GM-CSF and FMLP , and Sos1 and c-Raf-1 were not phosphorylated by GM-CSF , IL-3 , TNF , and FMLP in monocytes , whereas all these signaling molecules were affected and/or utilized by GM-CSF in MO7e cells .
among upstream signaling molecules of erk , shc was constitutively associated with grb2 and was not tyrosine -phosphorylated by gm-csf and fmlp , and sos1 and c-raf-1 were not phosphorylated by gm-csf , il-3 , tnf , and fmlp in monocytes , whereas all these signaling molecules were affected and/or utilized by gm-csf in mo7e cells .
O B-protein_family_or_group I-protein_family_or_group I-protein_family_or_group O B-protein_molecule O B-protein_molecule O O O O O O O O B-amino_acid_monomer O O B-protein_molecule O B-peptide O O B-protein_molecule O B-protein_molecule O O O O B-protein_molecule O O O O O O B-peptide O B-cell_type O O O O O O O O O O O B-protein_molecule O B-cell_type I-cell_type O