RA receptor activation appears critical to regulating important aspects of hematopoiesis , since transducing a COOH-terminally truncated RARalpha exhibiting dominant-negative activity ( RARalpha403 ) into normal mouse bone marrow generates hematopoietic growth factor-dependent cell lines frozen at the multipotent progenitor ( EML ) or committed promyelocyte ( MPRO ) stages .
ra receptor activation appears critical to regulating important aspects of hematopoiesis , since transducing a cooh-terminally truncated raralpha exhibiting dominant-negative activity ( raralpha403 ) into normal mouse bone marrow generates hematopoietic growth factor-dependent cell lines frozen at the multipotent progenitor ( eml ) or committed promyelocyte ( mpro ) stages .
B-other_organic_compound O O O O O O O O O B-other_name O O O O B-protein_molecule I-protein_molecule I-protein_molecule O O O O B-protein_molecule O O B-tissue I-tissue I-tissue I-tissue O B-cell_line I-cell_line I-cell_line I-cell_line I-cell_line O O O O O O O O O O O O O O O O