c-Fos protein was shown essential for an optimal transactivation of the HIV-1 long terminal repeat ( LTR ) by Tat : incubation of Jurkat cells with antisense , but not sense , c-fos oligonucleotides significantly reduced either the Tat -enhanced expression of an LTR-CAT reporter construct or the levels of gag p24 in the culture supernatants of Jurkat cells and PBMC acutely infected with HIV-1 .
c-fos protein was shown essential for an optimal transactivation of the hiv-1 long terminal repeat ( ltr ) by tat : incubation of jurkat cells with antisense , but not sense , c-fos oligonucleotides significantly reduced either the tat -enhanced expression of an ltr-cat reporter construct or the levels of gag p24 in the culture supernatants of jurkat cells and pbmc acutely infected with hiv-1 .
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