A point mutation of a potential phosphatidylinositol 3-kinase ( PI3-K ) binding site ( Y731EAM to Y731EAC ) in 70Z/3 disrupted the association of PI3-K with 70Z/3 , but did not reduce the induction of NFAT activity , suggesting that the interaction between Cbl and PI3-K is not required in the 70Z/3 -mediated induction of NFAT .
a point mutation of a potential phosphatidylinositol 3-kinase ( pi3-k ) binding site ( y731eam to y731eac ) in 70z/3 disrupted the association of pi3-k with 70z/3 , but did not reduce the induction of nfat activity , suggesting that the interaction between cbl and pi3-k is not required in the 70z/3 -mediated induction of nfat .
O O O O O O B-protein_molecule I-protein_molecule O B-protein_molecule O O O O B-DNA_domain_or_region O B-DNA_domain_or_region O O B-protein_molecule O O O O B-protein_molecule O B-protein_molecule O O O O O O O O B-protein_family_or_group O O O O O O O B-protein_molecule O B-protein_molecule O O O O O B-protein_molecule O O O B-protein_family_or_group O