These data suggest that in activated normal T cells , CD28 -derived signals can stimulate proliferation at least in part via NF-kappaB and AP-1 generation , and that this response uses both acidic sphingomyelinase and phosphatidylinositol 3-kinase -linked pathways .
these data suggest that in activated normal t cells , cd28 -derived signals can stimulate proliferation at least in part via nf-kappab and ap-1 generation , and that this response uses both acidic sphingomyelinase and phosphatidylinositol 3-kinase -linked pathways .
O O O O O O B-cell_type I-cell_type I-cell_type O B-protein_molecule O O O O O O O O O O O O O O O O O O O O O B-protein_molecule I-protein_molecule O B-protein_molecule I-protein_molecule O O O