CD40 ligation on MM by CD40L -transfected murine L-cells or by a soluble CD40L fusion protein up-regulated their expression of intercellular adhesion molecule-1 and MHC class I and class II molecules and their secretion of IL-6 , IL-8 , tumor necrosis factor-a , and granulocyte macrophage colony-stimulating factor and also induced a rapid activation of the transcription factor nuclear factor kappaB .
cd40 ligation on mm by cd40l -transfected murine l-cells or by a soluble cd40l fusion protein up-regulated their expression of intercellular adhesion molecule-1 and mhc class i and class ii molecules and their secretion of il-6 , il-8 , tumor necrosis factor-a , and granulocyte macrophage colony-stimulating factor and also induced a rapid activation of the transcription factor nuclear factor kappab .
B-protein_molecule O O B-tissue O B-protein_molecule O O O O O O O B-protein_molecule O O O O O O B-protein_molecule I-protein_molecule I-protein_molecule O O O O O O O O O O O O B-protein_molecule O B-protein_molecule O B-protein_molecule I-protein_molecule I-protein_molecule O O B-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule O O O O O O O O B-protein_family_or_group I-protein_family_or_group B-protein_complex I-protein_complex I-protein_complex O