However , the components of the NF-kappaB complexes were different in monocytes and B cells , because p50 is part of the NF-kappaB complex induced by CD40 triggering in both monocytes and B cells , whereas p65 was only induced in B cells . In contrast , although the Janus kinase 3 tyrosine kinase was associated with CD40 molecules in both monocytes and resting B cells , Janus kinase 3 phosphorylation induction was observed only in CD40 -activated monocytes , with subsequent induction of STAT5a DNA binding activity in the nucleus .
however , the components of the nf-kappab complexes were different in monocytes and b cells , because p50 is part of the nf-kappab complex induced by cd40 triggering in both monocytes and b cells , whereas p65 was only induced in b cells . in contrast , although the janus kinase 3 tyrosine kinase was associated with cd40 molecules in both monocytes and resting b cells , janus kinase 3 phosphorylation induction was observed only in cd40 -activated monocytes , with subsequent induction of stat5a dna binding activity in the nucleus .
O O O O O O B-protein_complex O O O O B-cell_type O O O O O B-protein_subunit O O O O B-protein_complex O O O B-protein_molecule O O O B-cell_type O B-cell_type I-cell_type O O B-protein_subunit O O O O B-cell_type I-cell_type O O O O O O B-protein_molecule I-protein_molecule I-protein_molecule B-amino_acid_monomer O O O O B-protein_molecule O O O B-cell_type O B-cell_type I-cell_type I-cell_type O B-protein_molecule I-protein_molecule I-protein_molecule O O O O O O B-protein_molecule O O O O O O O B-protein_molecule O O O O O B-cell_component O