The pre-leukemic phase of Friend erythroleukemia results from activation of the erythropoietin receptor ( EpoR ) by the spleen focus forming virus ( SFFV ) envelope glycoprotein , followed by the emergence of leukemic clones characterized by overexpression of Spi-1 and mutation of the p53 tumor suppressor gene .
the pre-leukemic phase of friend erythroleukemia results from activation of the erythropoietin receptor ( epor ) by the spleen focus forming virus ( sffv ) envelope glycoprotein , followed by the emergence of leukemic clones characterized by overexpression of spi-1 and mutation of the p53 tumor suppressor gene .
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