With these clones , we demonstrated that NFAT activation induced by phorbol 12-myristate 13-acetate and ionomycin was inhibited by both cyclosporin A ( CsA ) ( IC50 = 8 nM ) and FK506 ( IC50 = 160 pM ) , presumably by inhibition of calcineurin activity .
with these clones , we demonstrated that nfat activation induced by phorbol 12-myristate 13-acetate and ionomycin was inhibited by both cyclosporin a ( csa ) ( ic50 = 8 nm ) and fk506 ( ic50 = 160 pm ) , presumably by inhibition of calcineurin activity .
O O O O O O O B-protein_molecule O O O B-other_organic_compound I-other_organic_compound I-other_organic_compound O B-other_organic_compound O O O O B-other_organic_compound I-other_organic_compound O B-other_organic_compound O O O O O O O O B-other_organic_compound O O O O O O O O O O O B-protein_molecule O O