Altogether , these results suggest that ATRA /9-cis RA may play a key role in FL hematopoiesis via a dual effect hypothetically mediated by interaction with the RAR/RXR heterodimer , ie , inhibition of HSC/ primitive HPC proliferation and induction of CFU-GEMM/ BFU-E/CFU-M shift from the multipotent / erythroid / monocytic to the granulocytic-neutrophilic differentiation program .
altogether , these results suggest that atra /9-cis ra may play a key role in fl hematopoiesis via a dual effect hypothetically mediated by interaction with the rar/rxr heterodimer , ie , inhibition of hsc/ primitive hpc proliferation and induction of cfu-gemm/ bfu-e/cfu-m shift from the multipotent / erythroid / monocytic to the granulocytic-neutrophilic differentiation program .
O O O O O O B-other_organic_compound B-other_organic_compound I-other_organic_compound O O O O O O B-body_part O O O O O O O O O O O B-protein_complex I-protein_complex O O O O O B-cell_line I-cell_line I-cell_line O O O O B-other_name I-other_name I-other_name O O O O O O O O O O O O O