Thus , the use of DNase I allowed us , for the first time , to correlate the AIR-1 locus defect with class II promoter occupancy alterations and distinguish these alterations from the ones observed in phenotypically similar but genetically distinct MHC class II-negative cells .
thus , the use of dnase i allowed us , for the first time , to correlate the air-1 locus defect with class ii promoter occupancy alterations and distinguish these alterations from the ones observed in phenotypically similar but genetically distinct mhc class ii-negative cells .
O O O O O B-protein_molecule I-protein_molecule O O O O O O O O O O O B-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region O B-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region O O O O O O O O O O O O O O O O B-cell_line I-cell_line I-cell_line I-cell_line O