In the present study , analysis of the interleukin-2 ( IL-2 ) gene activation shows that naive human helper T cells ( cord blood CD4+ T cells , adult CD4+CD45RO- T cells ) regulate IL-2 transcription by a mechanism involving both a silencer and an activator acting on the purine-rich IL-2 promoter elements ( NF-AT binding sites ) .
in the present study , analysis of the interleukin-2 ( il-2 ) gene activation shows that naive human helper t cells ( cord blood cd4+ t cells , adult cd4+cd45ro- t cells ) regulate il-2 transcription by a mechanism involving both a silencer and an activator acting on the purine-rich il-2 promoter elements ( nf-at binding sites ) .
O O O O O O O O B-protein_molecule O B-protein_molecule O O O O O B-cell_type I-cell_type I-cell_type I-cell_type I-cell_type O B-cell_type I-cell_type I-cell_type I-cell_type I-cell_type O B-cell_type I-cell_type I-cell_type I-cell_type O O B-protein_molecule O O O O O O O B-DNA_family_or_group O O B-DNA_family_or_group O O O B-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region O B-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region O O