These results suggest that 1 ) lipid A myristoyl fatty acid , although it is important for the induction of inflammatory cytokine production by human monocytes , is not necessary for the induction of Mn SOD , 2 ) endotoxin -mediated induction of Mn SOD and inflammatory cytokines are regulated , at least in part , through different signal transduction pathways , and 3 ) failure of the mutant endotoxin to induce tumor necrosis factor-alpha production is , at least in part , due to its inability to activate mitogen-activated protein kinase .
these results suggest that 1 ) lipid a myristoyl fatty acid , although it is important for the induction of inflammatory cytokine production by human monocytes , is not necessary for the induction of mn sod , 2 ) endotoxin -mediated induction of mn sod and inflammatory cytokines are regulated , at least in part , through different signal transduction pathways , and 3 ) failure of the mutant endotoxin to induce tumor necrosis factor-alpha production is , at least in part , due to its inability to activate mitogen-activated protein kinase .
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