The visualization of heavy and light chain genes in B-lymphoid cells showed that the three Ig genes are differentially and nonrandomly distributed in different nuclear subvolumes : the kappa genes were found to be preferentially confined to an outer nuclear volume , whereas the gamma and lambda genes consistently occupied more central positions within the nucleus , the lambda genes being more interior when compared with the gamma genes .
the visualization of heavy and light chain genes in b-lymphoid cells showed that the three ig genes are differentially and nonrandomly distributed in different nuclear subvolumes : the kappa genes were found to be preferentially confined to an outer nuclear volume , whereas the gamma and lambda genes consistently occupied more central positions within the nucleus , the lambda genes being more interior when compared with the gamma genes .
O O O O O O O O O B-cell_type I-cell_type O O O O B-DNA_family_or_group I-DNA_family_or_group O O O O O O O O O O O B-DNA_family_or_group I-DNA_family_or_group O O O O O O O O O O O O O O O O O O O O O O O O O B-cell_component O O B-DNA_family_or_group I-DNA_family_or_group O O O O O O O B-DNA_family_or_group I-DNA_family_or_group O