We found , however , that PI 3-kinase profoundly influenced the transactivation capacity of ' nuclear factor of activated T cells ' ( NF-AT ) elicited by the TCR : expression of an activated form of PI 3-kinase inhibited TCR -mediated NF-AT responses , whereas expression of a dominant negative mutant of PI 3-kinase potently enhanced TCR -controlled NF-AT induction .
we found , however , that pi 3-kinase profoundly influenced the transactivation capacity of ' nuclear factor of activated t cells ' ( nf-at ) elicited by the tcr : expression of an activated form of pi 3-kinase inhibited tcr -mediated nf-at responses , whereas expression of a dominant negative mutant of pi 3-kinase potently enhanced tcr -controlled nf-at induction .
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