These results indicate that Bcl-2 acts downstream of MAPK kinase-1 but upstream of MAPK and suggest that , in the signaling pathway of the apoptotic process induced by bufalin , the transcriptional activity of activator protein-1 may be down-regulated through the inhibition of MAPK activity by Bcl-2 .
these results indicate that bcl-2 acts downstream of mapk kinase-1 but upstream of mapk and suggest that , in the signaling pathway of the apoptotic process induced by bufalin , the transcriptional activity of activator protein-1 may be down-regulated through the inhibition of mapk activity by bcl-2 .
O O O O B-protein_molecule O O O B-protein_family_or_group O O O O B-protein_family_or_group O O O O O O B-other_name I-other_name O O O O O O B-other_organic_compound O O O O O B-protein_molecule I-protein_molecule O O O O O O O B-protein_family_or_group O O B-protein_molecule O