The mechanism of corticosteroid resistance in bronchial asthma has been studied by determining the rank order of potency for different corticosteroids in inhibiting the generation of a 3 kD molecule from peripheral blood monocytes isolated from corticosteroid-sensitive ( CS ) and corticosteroid-resistant ( CR ) asthmatic subjects , which augments leukotriene B4 ( LTB4 ) generation by human neutrophils ( PMN ) stimulated by calcium ionophore .
the mechanism of corticosteroid resistance in bronchial asthma has been studied by determining the rank order of potency for different corticosteroids in inhibiting the generation of a 3 kd molecule from peripheral blood monocytes isolated from corticosteroid-sensitive ( cs ) and corticosteroid-resistant ( cr ) asthmatic subjects , which augments leukotriene b4 ( ltb4 ) generation by human neutrophils ( pmn ) stimulated by calcium ionophore .
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