The 271C --> T substitution represents a considerable change in chemical nature ( Arg91 --> Cys ) , one which may affect the antigenic determinants of DARC , and thus be of clinical significance .
the 271c --> t substitution represents a considerable change in chemical nature ( arg91 --> cys ) , one which may affect the antigenic determinants of darc , and thus be of clinical significance .
O B-nucleotide O B-nucleotide O O O O O O O O O B-amino_acid_monomer O B-amino_acid_monomer O O O O O O O O O O B-protein_molecule O O O O O O O O