Using a combination of bacterial motility assays in platelet extracts with Escherichia coli expressing the Shigella IcsA protein and in vitro analysis of reconstituted systems from purified proteins , we show here that the bacterial protein IcsA binds N-WASP and activates it in a Cdc42 -like fashion .
using a combination of bacterial motility assays in platelet extracts with escherichia coli expressing the shigella icsa protein and in vitro analysis of reconstituted systems from purified proteins , we show here that the bacterial protein icsa binds n-wasp and activates it in a cdc42 -like fashion .
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