To determine whether it is possible to artificially enhance the opening of the chromatin structure of a minimal beta-globin promoter , we placed a 101bp , erythroid-specific DNase 1 hypersensitive site-forming element ( HSFE ) immediately upstream of the beta-globin promoter and gene .
to determine whether it is possible to artificially enhance the opening of the chromatin structure of a minimal beta-globin promoter , we placed a 101bp , erythroid-specific dnase 1 hypersensitive site-forming element ( hsfe ) immediately upstream of the beta-globin promoter and gene .
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