Here we report that human leukaemia cells carrying the translocation t ( 17 ; 19 ) rapidly died by apoptosis when programmed to express a dominant-negative suppressor of the fusion protein E2A-HLF , indicating that the chimaeric oncoprotein probably affects cell survival rather than cell growth .
here we report that human leukaemia cells carrying the translocation t ( 17 ; 19 ) rapidly died by apoptosis when programmed to express a dominant-negative suppressor of the fusion protein e2a-hlf , indicating that the chimaeric oncoprotein probably affects cell survival rather than cell growth .
O O O O B-cell_type I-cell_type I-cell_type O O O B-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region O O O B-other_name O O O O O O O O O O O B-protein_molecule O O O O B-protein_family_or_group I-protein_family_or_group O O B-other_name I-other_name O O B-other_name I-other_name O