To investigate the molecular basis for the critical regulatory interaction between NF-kappa B and I kappa B/MAD-3 , a series of human NF-kappa B p65 mutants was identified that functionally segregated DNA binding , I kappa B -mediated inhibition , and I kappa B -induced nuclear exclusion of this transcription factor .
to investigate the molecular basis for the critical regulatory interaction between nf-kappa b and i kappa b/mad-3 , a series of human nf-kappa b p65 mutants was identified that functionally segregated dna binding , i kappa b -mediated inhibition , and i kappa b -induced nuclear exclusion of this transcription factor .
O O O O O O O O O O O B-protein_molecule I-protein_molecule O B-protein_molecule I-protein_molecule I-protein_molecule O O O O B-protein_family_or_group B-protein_subunit I-protein_subunit I-protein_subunit O O O O O O O O O B-protein_molecule I-protein_molecule I-protein_molecule O O O O B-protein_molecule I-protein_molecule I-protein_molecule O O O O O B-protein_family_or_group I-protein_family_or_group O