Secreted TNF-alpha mediated the enhancement of nuclear factor kappa B ( NF-kappa B ) and activator protein-1 ( AP-1 ) binding activity ; in fact , the triggering of HLA-DR antigens in the presence of antihuman TNF-alpha -neutralizing antibodies did not upregulate NF-kappa B and AP-1 .
secreted tnf-alpha mediated the enhancement of nuclear factor kappa b ( nf-kappa b ) and activator protein-1 ( ap-1 ) binding activity ; in fact , the triggering of hla-dr antigens in the presence of antihuman tnf-alpha -neutralizing antibodies did not upregulate nf-kappa b and ap-1 .
O B-protein_molecule O O O O B-protein_complex I-protein_complex I-protein_complex I-protein_complex O B-protein_complex I-protein_complex O O O O O B-protein_molecule O O O O O O O O O O B-protein_family_or_group I-protein_family_or_group O O O O B-protein_family_or_group B-protein_molecule O O O O O B-protein_complex I-protein_complex O B-protein_molecule O