The B cell-associated surface molecule CD40 plays a key role in T cell-dependent B cell maturation , as individuals with defects in either CD40 or its ligand are impaired in immunoglobulin isotype class switching and germinal center formation .
the b cell-associated surface molecule cd40 plays a key role in t cell-dependent b cell maturation , as individuals with defects in either cd40 or its ligand are impaired in immunoglobulin isotype class switching and germinal center formation .
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