Since one of the two X chromosomes is randomly inactivated at an early stage of female embryonic development , X-linked markers have been used to study the origin and development of various neoplastic disorders in affected heterozygous women ; clonality assays have provided a useful tool to the understanding of the mechanisms underlying the development of neoplasia .
since one of the two x chromosomes is randomly inactivated at an early stage of female embryonic development , x-linked markers have been used to study the origin and development of various neoplastic disorders in affected heterozygous women ; clonality assays have provided a useful tool to the understanding of the mechanisms underlying the development of neoplasia .
O O O O O B-DNA_molecule I-DNA_molecule O O O O O O O O B-other_name I-other_name I-other_name O B-protein_family_or_group I-protein_family_or_group O O O O O O O O O O O B-other_name I-other_name O O B-multi_cell I-multi_cell O B-other_name I-other_name O O O O O O O O O O O O O O O B-other_name O