Upon recurrence , however , the tumors sustained either deletion of p16 alone or codeletion of both p16 and p15 or amplification of CDK4 .
upon recurrence , however , the tumors sustained either deletion of p16 alone or codeletion of both p16 and p15 or amplification of cdk4 .
O O O O O O B-tissue O O O O B-protein_molecule O O O O O B-protein_molecule O B-protein_molecule O O O B-protein_molecule O