Thus , we postulated that the circadian modification of GR was independent of the diurnal fluctuations in plasma cortisol level or the circadian variations in environmental lighting and that the rhythmicity might be regulated by the ' circadian pacemaker ' located in the human basal brain .
thus , we postulated that the circadian modification of gr was independent of the diurnal fluctuations in plasma cortisol level or the circadian variations in environmental lighting and that the rhythmicity might be regulated by the ' circadian pacemaker ' located in the human basal brain .
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