Expression of MEK1 -interfering mutants inhibited the stimulation of IL-2 promoter -driven transcription and blocked the ability of constitutively active Ras and Raf-1 to costimulate NF-AT activity with a calcium ionophore .
expression of mek1 -interfering mutants inhibited the stimulation of il-2 promoter -driven transcription and blocked the ability of constitutively active ras and raf-1 to costimulate nf-at activity with a calcium ionophore .
O O B-protein_molecule O O O O O O B-protein_molecule O O O O O O O O O O B-protein_molecule O B-protein_molecule O O B-protein_family_or_group O O O B-other_organic_compound I-other_organic_compound O