Retention of the normal BRCA1 allele in the tumor with the heterozygous germline BRCA1 mutation , 2418delA , indicated that mutational inactivation of both BRCA1 alleles was not required for tumorigenesis .
retention of the normal brca1 allele in the tumor with the heterozygous germline brca1 mutation , 2418dela , indicated that mutational inactivation of both brca1 alleles was not required for tumorigenesis .
O O O O B-DNA_domain_or_region O O O O O O B-other_name I-other_name B-DNA_domain_or_region O O B-other_name O O O B-other_name I-other_name O O B-DNA_domain_or_region O O O O O B-other_name O