Additionally , to determine the impact of RXR for erythroid cell development , dominant interfering mutant RXRs , lacking the transcriptional activator functions AF-1 and AF-2 , or AF-2 only , or the entire DNA-binding domain , were introduced into erythroid progenitor cells via recombinant retrovirus vectors and analyzed for RXR -specific effects .
additionally , to determine the impact of rxr for erythroid cell development , dominant interfering mutant rxrs , lacking the transcriptional activator functions af-1 and af-2 , or af-2 only , or the entire dna-binding domain , were introduced into erythroid progenitor cells via recombinant retrovirus vectors and analyzed for rxr -specific effects .
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