By using the yeast two-hybrid system , we also show that EVI1 ( contained in its entirety in MDS1/EVI1 and AML1/MDS1/EVI1 ) physically interacts with SMAD3 , which is an intracellular mediator of TGF-beta1 signaling .
by using the yeast two-hybrid system , we also show that evi1 ( contained in its entirety in mds1/evi1 and aml1/mds1/evi1 ) physically interacts with smad3 , which is an intracellular mediator of tgf-beta1 signaling .
O O O O O O O O O O O B-protein_molecule O O O O O O B-DNA_domain_or_region O B-protein_molecule O O O O B-protein_molecule O O O O O O O B-protein_molecule O O