Analysis of targets that could mediate these phenotypic changes indicated that c-Maf likely plays a key role in myeloid cell development through dual mechanisms ; inhibition of a select set of c-Myb regulated targets , such as Bcl-2 and CD13/APN , coupled with the activation of as yet undefined differentiation-promoting genes .
analysis of targets that could mediate these phenotypic changes indicated that c-maf likely plays a key role in myeloid cell development through dual mechanisms ; inhibition of a select set of c-myb regulated targets , such as bcl-2 and cd13/apn , coupled with the activation of as yet undefined differentiation-promoting genes .
O O O O O O O O O O O B-protein_molecule O O O O O O O O O O O O O O O O O O O B-protein_molecule O O O O O B-protein_molecule O B-protein_molecule O O O O O O O O O B-DNA_family_or_group I-DNA_family_or_group O