The aberrant CD4 ( - ) CD8 ( - ) T cells from lpr/lpr and gld/gld mice , which have mutations in the genes encoding Fas and FasL , respectively , have an activated phenotype and constitutively express high levels of fasL mRNA , prompting us to ask what role if any the FLRE and Egr family proteins have in this aberrant expression of fasL .
the aberrant cd4 ( - ) cd8 ( - ) t cells from lpr/lpr and gld/gld mice , which have mutations in the genes encoding fas and fasl , respectively , have an activated phenotype and constitutively express high levels of fasl mrna , prompting us to ask what role if any the flre and egr family proteins have in this aberrant expression of fasl .
O B-cell_type I-cell_type I-cell_type I-cell_type I-cell_type I-cell_type I-cell_type I-cell_type I-cell_type I-cell_type I-cell_type O O O O O O O O O O O O O B-protein_molecule O B-protein_molecule O O O O O O O O O O O O O B-RNA_molecule I-RNA_molecule O O O O O O O O O O B-DNA_domain_or_region O B-protein_family_or_group I-protein_family_or_group I-protein_family_or_group O O O O O O B-protein_molecule O