Our studies show that the mechanism of IL-10 regulation of quiescent CD4 ( + ) T-cell activation is mainly by blocking induction of IL-2 that is critical to downregulation of p27 ( Kip1 ) and upregulation of D cyclins in T-cell activation and entry into the cell cycle .
our studies show that the mechanism of il-10 regulation of quiescent cd4 ( + ) t-cell activation is mainly by blocking induction of il-2 that is critical to downregulation of p27 ( kip1 ) and upregulation of d cyclins in t-cell activation and entry into the cell cycle .
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