In exerting their antiproliferative effects , GCS diffuse into target cells where they bind their cytoplasmic receptor , which in turn translocates to the nucleus where it inhibits transcription of cytokine genes through direct binding to the glucocorticoid response elements ( GRE ) , which are located in the promoter region of cytokine genes or , alternatively , through antagonism of the action of transcription factors required for optimal transcriptional activation .
in exerting their antiproliferative effects , gcs diffuse into target cells where they bind their cytoplasmic receptor , which in turn translocates to the nucleus where it inhibits transcription of cytokine genes through direct binding to the glucocorticoid response elements ( gre ) , which are located in the promoter region of cytokine genes or , alternatively , through antagonism of the action of transcription factors required for optimal transcriptional activation .
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