Here we have therefore examined the effect of the phorbol ester PMA ( phorbol 12-myristate 13-acetate ) which stimulates PKC and a combination of the adenosine receptor agonist NECA ( 5'- ( N-ethyl ) -carboxamido adenosine ) and forskolin to raise cAMP , on the levels of c-Fos and Jun and on the binding and transcriptional activity of the transcription factor , activator protein-1 ( AP-1 ) .
here we have therefore examined the effect of the phorbol ester pma ( phorbol 12-myristate 13-acetate ) which stimulates pkc and a combination of the adenosine receptor agonist neca ( 5'- ( n-ethyl ) -carboxamido adenosine ) and forskolin to raise camp , on the levels of c-fos and jun and on the binding and transcriptional activity of the transcription factor , activator protein-1 ( ap-1 ) .
O O O O O O O O O B-other_organic_compound I-other_organic_compound B-other_organic_compound O B-other_organic_compound I-other_organic_compound I-other_organic_compound O O O B-protein_molecule O O O O O B-protein_family_or_group I-protein_family_or_group O B-nucleotide O B-nucleotide I-nucleotide I-nucleotide I-nucleotide I-nucleotide I-nucleotide O O B-other_organic_compound O O B-nucleotide O O O O O B-protein_molecule O B-protein_molecule O O O O O B-other_name I-other_name O O B-protein_domain_or_region I-protein_domain_or_region O B-protein_molecule I-protein_molecule O B-protein_molecule O O