One of the latter elements , the IgH 3' enhancer , is of particular interest : ( 1 ) it is B cell-specific and active only in late B cell development ; ( 2 ) in rodent plasmacytomas and in some human Burkitt's lymphomas it is part of a locus control region ( LCR ) that is involved in deregulation of the c-myc oncogene as a result of translocation into the IgH locus ; and ( 3 ) it has been implicated in the mechanisms that control Ig gene class switch recombination .
one of the latter elements , the igh 3' enhancer , is of particular interest : ( 1 ) it is b cell-specific and active only in late b cell development ; ( 2 ) in rodent plasmacytomas and in some human burkitt's lymphomas it is part of a locus control region ( lcr ) that is involved in deregulation of the c-myc oncogene as a result of translocation into the igh locus ; and ( 3 ) it has been implicated in the mechanisms that control ig gene class switch recombination .
O O O O O O O B-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region O O O O O O O O O O O O O O O O O B-other_name I-other_name I-other_name I-other_name O O O O O B-tissue I-tissue O O O B-tissue I-tissue I-tissue O O O O O B-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region O B-DNA_domain_or_region O O O O O O O O B-DNA_domain_or_region O O O O O O O O B-DNA_domain_or_region I-DNA_domain_or_region O O O O O O O O O O O O O O B-DNA_family_or_group I-DNA_family_or_group I-DNA_family_or_group O O O