Enzymatic assay of alpha-galactosidase in blood leucocytes , skin fibroblasts , Epstein-Barr virus transformed lymphoid cell lines , and hair follicles of the twins and their parents confirmed the heterozygous status of the twins and indicated that Fabry disease had occurred as a result of a de novo mutation .
enzymatic assay of alpha-galactosidase in blood leucocytes , skin fibroblasts , epstein-barr virus transformed lymphoid cell lines , and hair follicles of the twins and their parents confirmed the heterozygous status of the twins and indicated that fabry disease had occurred as a result of a de novo mutation .
O O O B-protein_molecule O B-cell_type I-cell_type O B-cell_type I-cell_type O B-virus I-virus O O O O O O B-tissue I-tissue O O B-multi_cell O O B-multi_cell O O B-other_name I-other_name O O B-multi_cell O O O B-other_name I-other_name O O O O O O O O O O O