We demonstrate that the NF-microB-binding site plays a critical role in the IgH enhancer , because mutation of the microB DNA motif decreased transcriptional activity of the IgH enhancer in cells of the B-cell lineage but not in nonlymphoid cells .
we demonstrate that the nf-microb-binding site plays a critical role in the igh enhancer , because mutation of the microb dna motif decreased transcriptional activity of the igh enhancer in cells of the b-cell lineage but not in nonlymphoid cells .
O O O O B-DNA_domain_or_region I-DNA_domain_or_region O O O O O O B-DNA_domain_or_region I-DNA_domain_or_region O O O O O O O O O B-other_name I-other_name O O B-DNA_domain_or_region I-DNA_domain_or_region O O O O B-cell_type I-cell_type O O O B-cell_type I-cell_type O