Taken together , our findings indicate that signaling via CD27 on B cells induces IgE synthesis , in cooperation with IL-4 and CD40 signaling , by promoting the generation of plasma cells through up-regulation of positive regulatory domain I-binding factor-1 .
taken together , our findings indicate that signaling via cd27 on b cells induces ige synthesis , in cooperation with il-4 and cd40 signaling , by promoting the generation of plasma cells through up-regulation of positive regulatory domain i-binding factor-1 .
O O O O O O O O O B-protein_molecule O B-cell_type I-cell_type O B-protein_family_or_group O O O O O B-protein_molecule O B-protein_molecule O O O O O O O B-cell_type I-cell_type O O O B-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule O