The role of alterations of the MTS1 tumor suppressor gene on chromosome 9p21 , which encodes p16 , the inhibitor of cyclin-dependent-kinase- 4 and 6 , in tumorigenesis is not yet clear .
the role of alterations of the mts1 tumor suppressor gene on chromosome 9p21 , which encodes p16 , the inhibitor of cyclin-dependent-kinase- 4 and 6 , in tumorigenesis is not yet clear .
O O O O O O B-DNA_domain_or_region O O O O B-DNA_molecule I-DNA_molecule O O O B-protein_molecule O O O O O O O O O O B-other_name O O O O O