These results suggest that phosphorylated pRB is constitutively expressed in MM cells and that IL-6 further shifts pRB from its dephosphorylated to its phosphorylated form , thereby promoting MM cell growth via two mechanisms ; by decreasing the amount of E2F bound by dephosphorylated pRB due to reduced dephosphorylated pRB , thereby releasing growth arrest ; and by upregulating IL-6 secretion by MM cells and related IL-6 -mediated autocrine tumor cell growth .
these results suggest that phosphorylated prb is constitutively expressed in mm cells and that il-6 further shifts prb from its dephosphorylated to its phosphorylated form , thereby promoting mm cell growth via two mechanisms ; by decreasing the amount of e2f bound by dephosphorylated prb due to reduced dephosphorylated prb , thereby releasing growth arrest ; and by upregulating il-6 secretion by mm cells and related il-6 -mediated autocrine tumor cell growth .
O O O O B-protein_family_or_group B-protein_family_or_group O O O O B-cell_line I-cell_line O O B-protein_molecule O O B-protein_family_or_group O O O O O O O O O O B-other_name I-other_name I-other_name O O O O O O O O O O O O B-protein_family_or_group B-protein_family_or_group O O O B-protein_family_or_group B-protein_family_or_group O O O O O O O O O B-protein_molecule O O B-cell_line I-cell_line O O B-protein_molecule O O O O O O