NF-kappaB activation by LMP1 ( 1-231 ) is likely to be mediated by TRAF1 /TRAF2 heteroaggregates since TRAF1 is unique among the TRAFs in coactivating NF-kappaB with LMP1 ( 1-231 ) , a TRAF2 dominant-negative mutant can block LMP1 ( 1-231 ) -mediated NF-kappaB activation as well as TRAF1 coactivation , and 30% of TRAF2 is associated with TRAF1 in EBV-transformed B cells .
nf-kappab activation by lmp1 ( 1-231 ) is likely to be mediated by traf1 /traf2 heteroaggregates since traf1 is unique among the trafs in coactivating nf-kappab with lmp1 ( 1-231 ) , a traf2 dominant-negative mutant can block lmp1 ( 1-231 ) -mediated nf-kappab activation as well as traf1 coactivation , and 30% of traf2 is associated with traf1 in ebv-transformed b cells .
B-protein_molecule O O B-protein_molecule O O O O O O O O O B-protein_molecule B-protein_molecule O O B-protein_molecule O O O O B-protein_family_or_group O O B-protein_molecule O B-protein_molecule O O O O O B-protein_molecule O O O O B-protein_molecule O O O O B-protein_molecule O O O O B-protein_molecule O O O O O B-protein_molecule O O O B-protein_molecule O O O O O