The capacity of Syk to reconstitute the MAPK response required the catalytic activity of Syk , an intact autophosphorylation site ( Y518 and Y519 ) , both Src homology 2 domains and it was blocked by the inhibitory N17-mutated dominant-negative Ras construct .
the capacity of syk to reconstitute the mapk response required the catalytic activity of syk , an intact autophosphorylation site ( y518 and y519 ) , both src homology 2 domains and it was blocked by the inhibitory n17-mutated dominant-negative ras construct .
O O O B-protein_molecule O O O B-protein_family_or_group O O O O O O B-protein_molecule O O O B-protein_domain_or_region I-protein_domain_or_region O B-amino_acid_monomer O B-amino_acid_monomer O O O B-protein_domain_or_region I-protein_domain_or_region I-protein_domain_or_region I-protein_domain_or_region O O O O O O B-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule O