Despite stimulation with LPS , disruption of the NF-kappaB signaling pathway in precursor B cells led to the loss of inducible Oct-2 DNA binding activity in vitro and the suppression of Oct-2 -directed transcription in vivo .
despite stimulation with lps , disruption of the nf-kappab signaling pathway in precursor b cells led to the loss of inducible oct-2 dna binding activity in vitro and the suppression of oct-2 -directed transcription in vivo .
O O O B-lipid O O O O B-protein_complex O O O B-cell_type I-cell_type I-cell_type O O O O O O B-protein_molecule O O O O O O O O O B-protein_molecule O O O O O