Using a mitogenically incompetent human G-CSFR mutant in which Pro639 and Pro641 were substituted by alanine , the box 1 PDP motif was found to be required for activation of Jak kinases , tyrosine phosphorylation of the G-CSFR , and recruitment of Stat proteins .
using a mitogenically incompetent human g-csfr mutant in which pro639 and pro641 were substituted by alanine , the box 1 pdp motif was found to be required for activation of jak kinases , tyrosine phosphorylation of the g-csfr , and recruitment of stat proteins .
O O B-protein_molecule I-protein_molecule B-protein_molecule I-protein_molecule O O O B-amino_acid_monomer O B-amino_acid_monomer O O O B-amino_acid_monomer O O B-protein_domain_or_region I-protein_domain_or_region I-protein_domain_or_region I-protein_domain_or_region O O O O O O O O B-protein_family_or_group I-protein_family_or_group O B-amino_acid_monomer O O O B-protein_molecule O O O O B-protein_family_or_group I-protein_family_or_group O