T-cell receptor ( TCR ) /CD3 engagement results in the activation of nuclear factor of activated T cells ( NFAT ) , activator protein-1 ( AP-1 ) , and nuclear factor kappaB ( NFkappaB ) , whereas the CD28 responsive complex ( CD28RC ) is activated in response to the CD28 signal .
t-cell receptor ( tcr ) /cd3 engagement results in the activation of nuclear factor of activated t cells ( nfat ) , activator protein-1 ( ap-1 ) , and nuclear factor kappab ( nfkappab ) , whereas the cd28 responsive complex ( cd28rc ) is activated in response to the cd28 signal .
B-protein_family_or_group I-protein_family_or_group B-protein_complex I-protein_complex I-protein_complex I-protein_complex O O O O O O O O O B-cell_type I-cell_type I-cell_type O B-protein_family_or_group O O B-protein_molecule I-protein_molecule O B-protein_molecule O O O B-protein_complex I-protein_complex I-protein_complex O B-protein_complex O O O O B-protein_complex I-protein_complex I-protein_complex O B-protein_complex O O O O O O O B-protein_molecule O O