Targeted mutational analysis demonstrated that a tandem NF-kappa B /Rel binding motif is critical for the gamma 3 ECS responsiveness to both CD40L and IL-4 , while a STAT-6-binding site is additionally required for IL-4 inducibility .
targeted mutational analysis demonstrated that a tandem nf-kappa b /rel binding motif is critical for the gamma 3 ecs responsiveness to both cd40l and il-4 , while a stat-6-binding site is additionally required for il-4 inducibility .
O O O O O O O B-protein_complex I-protein_complex O O O O O O O B-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region O O O B-protein_molecule O B-protein_molecule O O O B-DNA_domain_or_region I-DNA_domain_or_region O O O O B-protein_molecule O O