We show in this work that mutations in either the purine -rich region of the CLEO element or the NF-kappa B site result in reduced PMA / Ca2+ activation of a 620-bp human GM-CSF promoter- luciferase reporter construct in Jurkat T cells by 65% and 50% , respectively .
we show in this work that mutations in either the purine -rich region of the cleo element or the nf-kappa b site result in reduced pma / ca2+ activation of a 620-bp human gm-csf promoter- luciferase reporter construct in jurkat t cells by 65% and 50% , respectively .
O O O O O O O O O O B-nucleotide O O O O B-DNA_domain_or_region O O O B-protein_molecule I-protein_molecule O O O O B-other_organic_compound O B-atom O O O B-DNA_molecule I-DNA_molecule B-protein_molecule O B-protein_molecule O O O B-cell_line B-cell_type I-cell_type O O O O O O O