These observations suggest that protein glycation in pancreatic beta cells , which occurs in vivo under chronic hyperglycemia , suppresses insulin gene transcription and thus can explain part of the beta cell glucose toxicity .
these observations suggest that protein glycation in pancreatic beta cells , which occurs in vivo under chronic hyperglycemia , suppresses insulin gene transcription and thus can explain part of the beta cell glucose toxicity .
O O O O B-other_name B-other_name O B-cell_type I-cell_type I-cell_type O O O O O O B-other_name I-other_name O O B-lipid O O O O O O O O O B-other_name I-other_name B-carbohydrate O O