When bound to cyclophilin , cyclosporin A binds and inactivates the key signalling intermediate calcineurin .
when bound to cyclophilin , cyclosporin a binds and inactivates the key signalling intermediate calcineurin .
O O O B-protein_molecule O B-other_organic_compound I-other_organic_compound O O O O B-other_name I-other_name I-other_name B-protein_molecule O