Transfection studies of LTR reporter constructs indicated that mutation of the DSE sites abrogated the LTR -mediated synergy induced by Ctx and TNFalpha , whereas the synergy induced by Ctx and IL-1beta was unaffected , suggesting TNFalpha and IL-1beta cooperate differently with the cAMP /PKA activation pathway to induce HIV-1 expression in U1 cells .
transfection studies of ltr reporter constructs indicated that mutation of the dse sites abrogated the ltr -mediated synergy induced by ctx and tnfalpha , whereas the synergy induced by ctx and il-1beta was unaffected , suggesting tnfalpha and il-1beta cooperate differently with the camp /pka activation pathway to induce hiv-1 expression in u1 cells .
O O O B-DNA_family_or_group I-DNA_family_or_group I-DNA_family_or_group O O O O O B-DNA_domain_or_region O O O B-DNA_domain_or_region O O O O B-protein_molecule O B-protein_molecule O O O O O O B-protein_molecule O B-protein_molecule O O O O B-protein_molecule O B-protein_molecule O O O O B-nucleotide B-protein_molecule O O O O B-virus O O B-cell_line I-cell_line O