We therefore reexamined this issue by using two different experimental approaches that allowed LMP1 -induced effects to be monitored immediately following expression of the viral protein and in the absence of selective pressures ; activation of the NF-kappa B transcription factor and upregulation of the cell adhesion molecule ICAM-1 were used as early indices of LMP1 function .
we therefore reexamined this issue by using two different experimental approaches that allowed lmp1 -induced effects to be monitored immediately following expression of the viral protein and in the absence of selective pressures ; activation of the nf-kappa b transcription factor and upregulation of the cell adhesion molecule icam-1 were used as early indices of lmp1 function .
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