Since the AES proteins are part of a set of transcriptional repressors encoded by the Enhancer of split [ E ( spl ) ] genes , and since these repressors are activated to suppress cell differentiation in response to Notch receptors signalling , the AES peptides may represent a novel class of self-antigens that deserve further consideration as tumor Ag in epithelial cancers .
since the aes proteins are part of a set of transcriptional repressors encoded by the enhancer of split [ e ( spl ) ] genes , and since these repressors are activated to suppress cell differentiation in response to notch receptors signalling , the aes peptides may represent a novel class of self-antigens that deserve further consideration as tumor ag in epithelial cancers .
O O B-protein_family_or_group I-protein_family_or_group O O O O O O O O O O O B-DNA_family_or_group I-DNA_family_or_group I-DNA_family_or_group I-DNA_family_or_group I-DNA_family_or_group I-DNA_family_or_group I-DNA_family_or_group I-DNA_family_or_group I-DNA_family_or_group I-DNA_family_or_group O O O O O O O O O O O O O O B-protein_family_or_group I-protein_family_or_group O O O B-peptide I-peptide O O O O O O B-protein_family_or_group O O O O O B-protein_family_or_group I-protein_family_or_group O B-other_name I-other_name O