In this work , we show that human peripheral blood T cells that are stimulated through the TCR and expanded with IL-2 are unresponsive to IFN-gamma , as determined by a lack of activation of jak kinases and the transcription factor , STAT1 ( alpha ) , a signal transducer and activator of transcription .
in this work , we show that human peripheral blood t cells that are stimulated through the tcr and expanded with il-2 are unresponsive to ifn-gamma , as determined by a lack of activation of jak kinases and the transcription factor , stat1 ( alpha ) , a signal transducer and activator of transcription .
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