Because the Nef protein does not affect the surface expression of the CD3 -TCR complex , we conclude that the Nef protein down-regulates the transcriptional factors NF-kappa B and AP-1 in T cells in vitro through an effect on the TCR-dependent signal transduction pathway .
because the nef protein does not affect the surface expression of the cd3 -tcr complex , we conclude that the nef protein down-regulates the transcriptional factors nf-kappa b and ap-1 in t cells in vitro through an effect on the tcr-dependent signal transduction pathway .
O O B-protein_molecule O O O O O O O O O B-protein_molecule O O O O O O O B-protein_molecule O O O O O B-protein_molecule I-protein_molecule O B-protein_molecule O B-cell_type I-cell_type O O O O O O O O B-other_name I-other_name O O