Since internal sites of oxidant production have been shown to play a key role in the cytokine -stimulated activation of NF-kappa B , and since tyrosine kinase and phosphatase activities are known to be altered by oxidants , these findings suggest that intracellular redox status controls NF-kappa B activation by regulating tyrosine phosphorylation event ( s ) within the common step of the NF-kappa B signal transduction pathway .
since internal sites of oxidant production have been shown to play a key role in the cytokine -stimulated activation of nf-kappa b , and since tyrosine kinase and phosphatase activities are known to be altered by oxidants , these findings suggest that intracellular redox status controls nf-kappa b activation by regulating tyrosine phosphorylation event ( s ) within the common step of the nf-kappa b signal transduction pathway .
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