A truncation mutant of LEF-1 ( HMG-88 ) , which contains the HMG box but lacks the trans-activation domain , did not activate transcription from nucleosomal DNA , indicating that bending of DNA by the HMG domain is not sufficient to activate transcription in vitro .
a truncation mutant of lef-1 ( hmg-88 ) , which contains the hmg box but lacks the trans-activation domain , did not activate transcription from nucleosomal dna , indicating that bending of dna by the hmg domain is not sufficient to activate transcription in vitro .
O B-protein_family_or_group I-protein_family_or_group O B-protein_molecule O B-protein_molecule O O O O O B-protein_domain_or_region I-protein_domain_or_region O O O B-protein_domain_or_region I-protein_domain_or_region O O O O B-other_name O B-DNA_family_or_group I-DNA_family_or_group O O O O O O O O B-protein_domain_or_region I-protein_domain_or_region O O O O O B-other_name O O O