However , disruption of a membrane-proximal proline-rich sequence motif ( ' box1 ' ) in either subunit of the bipartite IL-4R abolished not only ligand-induced tyrosine phosphorylation of Janus kinases JAK1 and JAK3 , but also IL-4 -triggered activation of STAT5 and concomitant cell proliferation .
however , disruption of a membrane-proximal proline-rich sequence motif ( ' box1 ' ) in either subunit of the bipartite il-4r abolished not only ligand-induced tyrosine phosphorylation of janus kinases jak1 and jak3 , but also il-4 -triggered activation of stat5 and concomitant cell proliferation .
O O O O O B-protein_substructure I-protein_substructure I-protein_substructure I-protein_substructure O O B-protein_substructure O O O O O O O B-protein_molecule I-protein_molecule O O O B-other_name B-amino_acid_monomer O O B-protein_family_or_group I-protein_family_or_group B-protein_molecule O B-protein_molecule O O O B-protein_molecule O O O B-protein_molecule O B-other_name B-other_name I-other_name O