Each second messenger is necessary , as inhibition of either one reverses the activation of the IKK complex and IkappaBalpha phosphorylation in vivo .
each second messenger is necessary , as inhibition of either one reverses the activation of the ikk complex and ikappabalpha phosphorylation in vivo .
O O O O O O O O O O O O O O O O B-protein_complex I-protein_complex O B-protein_molecule O O O O