We show that an inhibitor of protein phosphatases ( PPs ) PP1/PP2A , calyculin A , induces ( i ) phosphorylation of STAT3 on serine and threonine residues , ( ii ) inhibition of STAT3 tyrosine phosphorylation and DNA binding activity , and ( iii ) relocation of STAT3 from the nucleus to the cytoplasm .
we show that an inhibitor of protein phosphatases ( pps ) pp1/pp2a , calyculin a , induces ( i ) phosphorylation of stat3 on serine and threonine residues , ( ii ) inhibition of stat3 tyrosine phosphorylation and dna binding activity , and ( iii ) relocation of stat3 from the nucleus to the cytoplasm .
O O O O O O B-protein_family_or_group I-protein_family_or_group O B-protein_family_or_group O B-protein_molecule O B-protein_molecule I-protein_molecule O O O O O O O B-protein_molecule O B-amino_acid_monomer O B-amino_acid_monomer O O O O O O O B-protein_molecule B-amino_acid_monomer O O O O O O O O O O O O B-protein_molecule O O B-cell_component O O B-cell_component O