Together , these data demonstrate that the IL-4R alpha cytoplasmic domain is sufficient to activate JAK-1 and STAT6 and to induce expression of IL-4 target genes , thus identifying a mechanism by which IL-4 signaling can proceed in the absence of JAK-3 and gamma ( c ) .
together , these data demonstrate that the il-4r alpha cytoplasmic domain is sufficient to activate jak-1 and stat6 and to induce expression of il-4 target genes , thus identifying a mechanism by which il-4 signaling can proceed in the absence of jak-3 and gamma ( c ) .
O O O O O O O B-protein_domain_or_region I-protein_domain_or_region I-protein_domain_or_region I-protein_domain_or_region O O O O B-protein_molecule O B-protein_molecule O O O O O B-protein_molecule O O O O O O O O O B-protein_molecule O O O O O O O B-protein_molecule O B-protein_subunit I-protein_subunit I-protein_subunit I-protein_subunit O