These data provide the first demonstration in vivo that activation of a protein phosphatase can inactivate I kappa B , and suggest one possible explanation for mechanism-based toxicities associated with FK-506 and CsA by demonstrating that these drugs can inhibit the calcineurin -dependent activation of a virtually ubiquitous transcription factor .
these data provide the first demonstration in vivo that activation of a protein phosphatase can inactivate i kappa b , and suggest one possible explanation for mechanism-based toxicities associated with fk-506 and csa by demonstrating that these drugs can inhibit the calcineurin -dependent activation of a virtually ubiquitous transcription factor .
O O O O O O B-other_name I-other_name O O O O B-protein_family_or_group I-protein_family_or_group O O B-protein_molecule I-protein_molecule I-protein_molecule O O O O O O O B-other_name I-other_name O O B-other_organic_compound O B-other_organic_compound O O O O O O O O B-protein_molecule O O O O O B-protein_family_or_group I-protein_family_or_group I-protein_family_or_group O