The IL-12 nonresponsiveness of the Th2 clones was further evident by the total lack of IL-12 -induced phosphorylation of STAT4 ( signal transducer and activator of transcription-4 ) , a transcription factor that is typically involved in IL-12 signaling .
the il-12 nonresponsiveness of the th2 clones was further evident by the total lack of il-12 -induced phosphorylation of stat4 ( signal transducer and activator of transcription-4 ) , a transcription factor that is typically involved in il-12 signaling .
O B-protein_molecule O O O B-cell_line I-cell_line O O O O O O O O B-protein_molecule O O O B-protein_molecule O B-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule O O O B-protein_family_or_group I-protein_family_or_group O O O O O B-protein_molecule O O