Here we show that the activation of the IL-2 promoter by Tpl-2 is inhibited by mutant signaling molecules that inhibit the mitogen-activated protein kinase ( MAPK ) or the calcineurin /NFAT pathways and is promoted by combinations of signaling molecules that activate these pathways .
here we show that the activation of the il-2 promoter by tpl-2 is inhibited by mutant signaling molecules that inhibit the mitogen-activated protein kinase ( mapk ) or the calcineurin /nfat pathways and is promoted by combinations of signaling molecules that activate these pathways .
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