Nevertheless , in the two leukemia cell lines transient overexpression of p16 reestablished the normal regulation of thymidine kinase , paralleled by an increase of the underphosphorylated form of retinoblastoma protein and decrease of free E2F bound to its motif in the thymidine kinase promoter .
nevertheless , in the two leukemia cell lines transient overexpression of p16 reestablished the normal regulation of thymidine kinase , paralleled by an increase of the underphosphorylated form of retinoblastoma protein and decrease of free e2f bound to its motif in the thymidine kinase promoter .
O O O O O B-cell_line I-cell_line I-cell_line O O O B-protein_molecule O O O O O B-protein_family_or_group I-protein_family_or_group O O O O O O O O O O B-protein_family_or_group I-protein_family_or_group O O O O B-protein_molecule O O O O O O B-protein_family_or_group I-protein_family_or_group O O