Treatment of B lymphocytes with the cytokine IL-4 ( IL-4 ) , in the absence of prior activation , induces a weak up-regulation of VDR expression but fails to generate vitamin D-responsive element ( VDRE ) -reactive nuclear protein complexes or to initiate the genomic transcription of 25-hydroxyvitamin D3 24-hydroxylase .
treatment of b lymphocytes with the cytokine il-4 ( il-4 ) , in the absence of prior activation , induces a weak up-regulation of vdr expression but fails to generate vitamin d-responsive element ( vdre ) -reactive nuclear protein complexes or to initiate the genomic transcription of 25-hydroxyvitamin d3 24-hydroxylase .
O O B-cell_type I-cell_type O O B-protein_family_or_group B-protein_molecule O B-protein_molecule O O O O O O O O O O O O O O B-protein_family_or_group O O O O O B-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region O B-DNA_domain_or_region O O O O O O O O O O O O B-protein_molecule I-protein_molecule I-protein_molecule O