Tyloxapol inhibits activation of the transcription factor nuclear factor-kappa B ( NK-kappa B ) , reduces resting secretion of the cytokine interleukin-8 ( IL-8 ) in cultured human monocytes , and inhibits lipopolysaccharide ( LPS ) -stimulated release of tumor necrosis factor-alpha ( TNF-alpha ) , IL-1 beta , IL-6 , IL-8 , granulocyte-macrophage colony-stimulating factor ( GM-CSF ) , and the eiconsanoids thromboxane A2 and leukotriene B4 ( LTB4 ) .
tyloxapol inhibits activation of the transcription factor nuclear factor-kappa b ( nk-kappa b ) , reduces resting secretion of the cytokine interleukin-8 ( il-8 ) in cultured human monocytes , and inhibits lipopolysaccharide ( lps ) -stimulated release of tumor necrosis factor-alpha ( tnf-alpha ) , il-1 beta , il-6 , il-8 , granulocyte-macrophage colony-stimulating factor ( gm-csf ) , and the eiconsanoids thromboxane a2 and leukotriene b4 ( ltb4 ) .
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