In contrast , mutations in the AP-1 site located at -150 bp almost completely abrogate induction of the IL-2 promoter , and appearance of an inducible nuclear factor binding to this site is sensitive to PKC depletion .
in contrast , mutations in the ap-1 site located at -150 bp almost completely abrogate induction of the il-2 promoter , and appearance of an inducible nuclear factor binding to this site is sensitive to pkc depletion .
O O O O O O B-DNA_domain_or_region I-DNA_domain_or_region O O B-DNA_domain_or_region I-DNA_domain_or_region O O O O O O B-DNA_domain_or_region I-DNA_domain_or_region O O O O O B-protein_family_or_group I-protein_family_or_group I-protein_family_or_group O O O O O O O B-protein_molecule O O