Gene inactivation studies on the PU . 1 , Ikaros and GATA-3 genes have revealed that their encoded factors are essential for the earliest commitment step into the B and T lymphoid lineages .
gene inactivation studies on the pu . 1 , ikaros and gata-3 genes have revealed that their encoded factors are essential for the earliest commitment step into the b and t lymphoid lineages .
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