In all patients a marked decrease in IL-2 -producing cells and a significant increase in well-differentiated Th1 cells that produced IFN-gamma but not IL-2 were evident after priming with anti-CD3 and anti-CD28 .
in all patients a marked decrease in il-2 -producing cells and a significant increase in well-differentiated th1 cells that produced ifn-gamma but not il-2 were evident after priming with anti-cd3 and anti-cd28 .
O O B-multi_cell O O O O B-protein_molecule O O O O O O O O B-cell_type I-cell_type O O B-protein_molecule O O B-protein_molecule O O O O O B-protein_family_or_group O B-protein_family_or_group O