Our studies now demonstrate that HTLV-1 Tax activates the recently identified cellular kinases IkappaB kinase alpha ( IKKalpha ) and IKKbeta , which normally phosphorylate IkappaB alpha on both of its N-terminal regulatory serines in response to tumor necrosis factor alpha ( TNF-alpha ) and interleukin-1 ( IL-1 ) stimulation .
our studies now demonstrate that htlv-1 tax activates the recently identified cellular kinases ikappab kinase alpha ( ikkalpha ) and ikkbeta , which normally phosphorylate ikappab alpha on both of its n-terminal regulatory serines in response to tumor necrosis factor alpha ( tnf-alpha ) and interleukin-1 ( il-1 ) stimulation .
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