However , the combined treatment with PDTC and PMA , two agents that synergize on AP-1 activation , resulted in the persistent phosphorylation of ERK-2 .
however , the combined treatment with pdtc and pma , two agents that synergize on ap-1 activation , resulted in the persistent phosphorylation of erk-2 .
O O O O O O B-other_organic_compound O B-other_organic_compound O O O O O O B-protein_molecule O O O O O O O O B-protein_molecule O