We here report that ( i ) like PML-RAR alpha expression , PLZF-RAR alpha expression blocks terminal differentiation of hematopoietic precursor cell lines ( U937 and HL-60 ) in response to different stimuli ( vitamin D3 , transforming growth factor beta1 , and dimethyl sulfoxide ) ; ( ii ) PML-RAR alpha , but not PLZF-RAR alpha , increases RA sensitivity of hematopoietic precursor cells and restores RA sensitivity of RA-resistant hematopoietic cells ; ( iii ) PML-RAR alpha and PLZF-RAR alpha have similar RA binding affinities ; and ( iv ) PML-RAR alpha enhances the RA response of RA target genes ( those for RAR beta , RAR gamma , and transglutaminase type II [ TGase ] ) in vivo , while PLZF-RAR alpha expression has either no effect ( RAR beta ) or an inhibitory activity ( RAR gamma and type II TGase ) .
we here report that ( i ) like pml-rar alpha expression , plzf-rar alpha expression blocks terminal differentiation of hematopoietic precursor cell lines ( u937 and hl-60 ) in response to different stimuli ( vitamin d3 , transforming growth factor beta1 , and dimethyl sulfoxide ) ; ( ii ) pml-rar alpha , but not plzf-rar alpha , increases ra sensitivity of hematopoietic precursor cells and restores ra sensitivity of ra-resistant hematopoietic cells ; ( iii ) pml-rar alpha and plzf-rar alpha have similar ra binding affinities ; and ( iv ) pml-rar alpha enhances the ra response of ra target genes ( those for rar beta , rar gamma , and transglutaminase type ii [ tgase ] ) in vivo , while plzf-rar alpha expression has either no effect ( rar beta ) or an inhibitory activity ( rar gamma and type ii tgase ) .
O O O O O O O O B-protein_molecule I-protein_molecule O O B-protein_molecule I-protein_molecule O O O O O B-other_name I-other_name I-other_name I-other_name O B-cell_line O B-cell_line O O O O O O O B-other_organic_compound I-other_organic_compound O O O O B-other_organic_compound O O B-other_organic_compound I-other_organic_compound O O O O O B-protein_molecule I-protein_molecule O O O B-protein_molecule I-protein_molecule O O B-other_name I-other_name O B-cell_type I-cell_type I-cell_type O O B-other_name I-other_name O B-cell_type I-cell_type I-cell_type O O O O B-protein_molecule I-protein_molecule O B-protein_molecule I-protein_molecule O O B-other_organic_compound O O O O O O O B-protein_molecule I-protein_molecule O O B-other_organic_compound O O B-other_organic_compound O O O O O B-protein_molecule I-protein_molecule O B-protein_molecule I-protein_molecule O O B-protein_molecule I-protein_molecule I-protein_molecule O B-protein_molecule O O O O O O B-protein_molecule I-protein_molecule O O O O O O B-protein_molecule I-protein_molecule O O O O O O B-protein_molecule I-protein_molecule O B-protein_molecule I-protein_molecule B-protein_molecule O O