At present , it is unclear whether the lack of PU . 1 expression and activity in human multiple myeloma cell lines represents a malignancy-associated defect in these cells or exemplifies a normal developmental regulation in terminally differentiated B cells .
at present , it is unclear whether the lack of pu . 1 expression and activity in human multiple myeloma cell lines represents a malignancy-associated defect in these cells or exemplifies a normal developmental regulation in terminally differentiated b cells .
O O O O O O O O O O B-protein_molecule I-protein_molecule I-protein_molecule O O O O B-cell_line B-cell_line I-cell_line I-cell_line I-cell_line O O O O O O O O O O O O O O B-cell_type I-cell_type B-cell_type I-cell_type O