During the differentiation of naive CD4 ( + ) T cells isolated from T cell receptor transgenic mice , GATA-3 gene expression was up-regulated in developing Th2 cells , but was down-regulated in Th1 cells , and antigen- or cAMP-activated Th2 cells ( but not Th1 cells ) expressed the GATA-3 protein .
during the differentiation of naive cd4 ( + ) t cells isolated from t cell receptor transgenic mice , gata-3 gene expression was up-regulated in developing th2 cells , but was down-regulated in th1 cells , and antigen- or camp-activated th2 cells ( but not th1 cells ) expressed the gata-3 protein .
O O O O B-cell_type I-cell_type I-cell_type I-cell_type I-cell_type I-cell_type I-cell_type O O B-other_artificial_source I-other_artificial_source I-other_artificial_source I-other_artificial_source I-other_artificial_source O B-protein_molecule O O O O O O B-cell_type I-cell_type O O O O O B-cell_type I-cell_type O O B-cell_type I-cell_type I-cell_type B-cell_type I-cell_type O O O B-cell_type I-cell_type O O O B-protein_molecule O O