On the basis of binding , reconstitution and cotransfection experiments , we propose that activation of NF-AT occurs in at least two stages : a CsA -sensitive stage involving modification and/or translocation of the pre-existing NF-AT complex , and a CsA -insensitive stage involving the addition of newly synthesized Fos or Fos/Jun proteins to the pre-existing complex .
on the basis of binding , reconstitution and cotransfection experiments , we propose that activation of nf-at occurs in at least two stages : a csa -sensitive stage involving modification and/or translocation of the pre-existing nf-at complex , and a csa -insensitive stage involving the addition of newly synthesized fos or fos/jun proteins to the pre-existing complex .
O O O O O O O O O O O O O O O O B-protein_molecule O O O O O O O O B-other_organic_compound O O O O O O O O O B-protein_molecule O O O O B-other_organic_compound O O O O O O O O B-protein_molecule O B-protein_molecule I-protein_molecule O O B-protein_complex I-protein_complex O