Altogether , our data demonstrate that : ( a ) the ability of B cells to release TNF-alpha after triggering of HLA-DR antigens depends on their stage of differentiation ; ( b ) levels of released TNF-alpha seem to correlate with the stage of B-cell maturation but do not correlate with the amounts of cell surface HLA-DR antigens ; ( c ) secreted TNF-alpha regulates the levels of expression of NF-kappa B and AP-1 by an autocrine loop ; and ( d ) intracellular signals mediating TNF-alpha release by B cells are distinct from those regulating homotypic aggregation and proliferation .
altogether , our data demonstrate that : ( a ) the ability of b cells to release tnf-alpha after triggering of hla-dr antigens depends on their stage of differentiation ; ( b ) levels of released tnf-alpha seem to correlate with the stage of b-cell maturation but do not correlate with the amounts of cell surface hla-dr antigens ; ( c ) secreted tnf-alpha regulates the levels of expression of nf-kappa b and ap-1 by an autocrine loop ; and ( d ) intracellular signals mediating tnf-alpha release by b cells are distinct from those regulating homotypic aggregation and proliferation .
O O O O O O O O O O O O O B-cell_type I-cell_type O O B-protein_molecule O O O B-protein_family_or_group I-protein_family_or_group O O O O O O O O O O O O O B-protein_molecule O O O O O O O B-other_name I-other_name O O O O O O O O B-protein_family_or_group I-protein_family_or_group B-protein_family_or_group I-protein_family_or_group O O O O O B-protein_molecule O O O O O O B-protein_complex I-protein_complex O B-protein_molecule O O B-other_name I-other_name O O O O O B-other_name I-other_name O B-protein_molecule O O B-cell_type I-cell_type O O O O O O O O O O