Moreover , IL-4 costimulation with IL-2 or IL-12 does not alter their own preferential GAS -like DNA binding patterns when C epsilon- , Fc gamma RI- , and SIE GAS motif containing oligonucleotide probes are compared , suggesting that induction of GAS-like DNA-protein binding complexes by IL-2 , IL-4 , and IL-12 is highly selective and represents one important factor in determining specific gene activation .
moreover , il-4 costimulation with il-2 or il-12 does not alter their own preferential gas -like dna binding patterns when c epsilon- , fc gamma ri- , and sie gas motif containing oligonucleotide probes are compared , suggesting that induction of gas-like dna-protein binding complexes by il-2 , il-4 , and il-12 is highly selective and represents one important factor in determining specific gene activation .
O O B-protein_molecule O O B-protein_molecule O B-protein_molecule O O O O O O B-DNA_domain_or_region O O O O O O O O O O O O O O O O O B-polynucleotide I-polynucleotide O O O O O O O B-protein_complex I-protein_complex I-protein_complex I-protein_complex O B-protein_molecule O B-protein_molecule O O B-protein_molecule O O O O O O O O O O O B-other_name I-other_name O