Using a structure-function mutagenesis approach , two tyrosine residues ( Tyr427 and Tyr477 ) in the intracellular domain of the murine IL-10 receptor were found to be redundantly required for receptor function and for activation of Stat3 but not for Stat1 or Stat5 .
using a structure-function mutagenesis approach , two tyrosine residues ( tyr427 and tyr477 ) in the intracellular domain of the murine il-10 receptor were found to be redundantly required for receptor function and for activation of stat3 but not for stat1 or stat5 .
O O O O O O O B-amino_acid_monomer I-amino_acid_monomer O B-amino_acid_monomer O B-amino_acid_monomer O O O B-protein_domain_or_region I-protein_domain_or_region O O O B-protein_molecule O O O O O O O O B-other_name I-other_name O O O O B-protein_molecule O O O B-protein_molecule O B-protein_molecule O