Thus , our experiments demonstrate that the C-terminal region of HIV-1 Tat is required to suppress Mn-SOD expression and to induce pro-oxidative conditions reflected by a drop in reduced glutathione ( GSH ) and the GSH : oxidized GSH ( GSSG ) ratio .
thus , our experiments demonstrate that the c-terminal region of hiv-1 tat is required to suppress mn-sod expression and to induce pro-oxidative conditions reflected by a drop in reduced glutathione ( gsh ) and the gsh : oxidized gsh ( gssg ) ratio .
O O O O O O O B-protein_domain_or_region I-protein_domain_or_region O B-virus B-protein_molecule O O O O B-protein_molecule O O O O O O O O O O O O B-peptide O B-protein_molecule O O O B-other_name I-other_name I-other_name B-peptide O B-peptide O O O