PO-B was originally characterized as a transcriptional regulatory factor of the pro-opiomelanocortin ( POMC ) gene ; however , it has become increasingly clear that this protein may be active in tissues outside the pituitary , since it is present in diverse cell types , including differentiated HL-60 promyelocytic leukemia cells .
po-b was originally characterized as a transcriptional regulatory factor of the pro-opiomelanocortin ( pomc ) gene ; however , it has become increasingly clear that this protein may be active in tissues outside the pituitary , since it is present in diverse cell types , including differentiated hl-60 promyelocytic leukemia cells .
B-protein_molecule O O O O O B-protein_molecule I-protein_molecule I-protein_molecule O O B-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region O O O O O O O O O O O O O O O O O O B-body_part O O O O O O O O O O O O B-cell_type I-cell_type I-cell_type I-cell_type O