Mutations of the CRE site that result in loss of CREB binding also lead to loss of functional activity of the bcl-2 promoter in transient-transfection assays .
mutations of the cre site that result in loss of creb binding also lead to loss of functional activity of the bcl-2 promoter in transient-transfection assays .
O O O B-DNA_domain_or_region I-DNA_domain_or_region O O O O O B-protein_molecule O O O O O O O O O O O O O O O O