Hypermethylation within the promoters of some genes appear to be an early event in the pathogenesis of neoplasia ( ER , P15 ) , while other genes seem to become methylated during the progression of leukemias ( HIC1 , c-abl ) .
hypermethylation within the promoters of some genes appear to be an early event in the pathogenesis of neoplasia ( er , p15 ) , while other genes seem to become methylated during the progression of leukemias ( hic1 , c-abl ) .
B-other_name O O B-DNA_domain_or_region O O O O O O O O O O O O O B-other_name O B-DNA_domain_or_region O B-DNA_domain_or_region O O O O O O O O O O O O O B-other_name O O O O O O