SHP1 -DeltaSH2 also inhibited events downstream of ZAP-70 and Syk , such as activation of the mitogen-activated protein kinase Erk2 and the transcriptional activation of the interleukin-2 gene .
shp1 -deltash2 also inhibited events downstream of zap-70 and syk , such as activation of the mitogen-activated protein kinase erk2 and the transcriptional activation of the interleukin-2 gene .
B-protein_molecule O O O O O O B-protein_molecule O B-protein_molecule O O O O O O B-protein_family_or_group I-protein_family_or_group I-protein_family_or_group B-protein_molecule O O O O O O B-protein_molecule O O