We conclude that ( 1 ) HTLV-I infection per se does not result in a constitutive phosphorylation of the Jak3 , STAT3 , and STAT5 proteins ; ( 2 ) malignant transformation in at least some cases of ATLL does not require the constitutive , but may require IL-2 -induced , activation of the IL-2R Jak/STAT pathway ; and ( 3 ) there are major differences in T-cell immortalization mechanism ( s ) which appear to involve SHP-1 and target molecules for rapamycin and RAD .
we conclude that ( 1 ) htlv-i infection per se does not result in a constitutive phosphorylation of the jak3 , stat3 , and stat5 proteins ; ( 2 ) malignant transformation in at least some cases of atll does not require the constitutive , but may require il-2 -induced , activation of the il-2r jak/stat pathway ; and ( 3 ) there are major differences in t-cell immortalization mechanism ( s ) which appear to involve shp-1 and target molecules for rapamycin and rad .
O O O O O O B-virus O O O O O O O O B-other_name I-other_name O O B-protein_molecule O B-protein_molecule O O B-protein_molecule O O O O O O O O O O O O O B-other_name O O O O O O O O O B-protein_molecule O O O O O B-protein_molecule B-protein_family_or_group O O O O O O O O O O O B-other_name I-other_name I-other_name O O O O O O O B-protein_molecule O O O O B-other_organic_compound O B-other_organic_compound O