Mutations that abolish the binding of each factor to its cognate site are introduced in an infectious HIV-1 molecular clone to study their effect on HIV-1 transcription and replication .
mutations that abolish the binding of each factor to its cognate site are introduced in an infectious hiv-1 molecular clone to study their effect on hiv-1 transcription and replication .
O O O O O O O O O O O O O O O O B-virus B-virus O O O O O O O B-virus O O O O