We have previously shown that prolonged treatment of the untransformed T cell clone Ar-5 with phorbol esters results in downmodulation of the alpha and beta isozymes of PKC , and abrogates induction of IL-2 mRNA and protein .
we have previously shown that prolonged treatment of the untransformed t cell clone ar-5 with phorbol esters results in downmodulation of the alpha and beta isozymes of pkc , and abrogates induction of il-2 mrna and protein .
O O O O O O O O O O B-cell_line I-cell_line I-cell_line I-cell_line O B-other_organic_compound I-other_organic_compound O O O O O O O O O O B-protein_molecule O O O O O B-RNA_molecule I-RNA_molecule O B-protein_molecule O