Studies of the mechanisms that enable EBV to infect nonactivated , noncycling B cells provide compelling evidence for a sequence of events in which EBV binding to CD21 on purified resting human B cells rapidly activates the NF-kappaB transcription factor , which , in turn , binds to and mediates transcriptional activation of Wp , the initial viral latent gene promoter .
studies of the mechanisms that enable ebv to infect nonactivated , noncycling b cells provide compelling evidence for a sequence of events in which ebv binding to cd21 on purified resting human b cells rapidly activates the nf-kappab transcription factor , which , in turn , binds to and mediates transcriptional activation of wp , the initial viral latent gene promoter .
O O O O O O B-virus O O O O B-cell_type I-cell_type I-cell_type O O O O O O O O O O B-virus O O B-protein_molecule O O B-cell_type I-cell_type I-cell_type I-cell_type O O O B-protein_complex B-protein_family_or_group I-protein_family_or_group O O O O O O O O O O O O O O O O O B-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region O