However , in contrast to the wild-type endotoxin , it failed to induce significant production of tumor necrosis factor-alpha and macrophage inflammatory protein-1alpha by monocytes and did not induce the phosphorylation and nuclear translocation of mitogen-activated protein kinase .
however , in contrast to the wild-type endotoxin , it failed to induce significant production of tumor necrosis factor-alpha and macrophage inflammatory protein-1alpha by monocytes and did not induce the phosphorylation and nuclear translocation of mitogen-activated protein kinase .
O O O O O O O O O O O O O O O O B-protein_molecule I-protein_molecule I-protein_molecule O B-protein_molecule I-protein_molecule I-protein_molecule O B-cell_type O O O O O O O B-other_name I-other_name O B-protein_family_or_group I-protein_family_or_group I-protein_family_or_group O