Abnormalities of retinoblastoma protein ( pRB ) and mutations of RB gene have been reported in up to 70% of MM patients and 80% of MM-derived cell lines .
abnormalities of retinoblastoma protein ( prb ) and mutations of rb gene have been reported in up to 70% of mm patients and 80% of mm-derived cell lines .
O O B-protein_family_or_group I-protein_family_or_group O B-protein_family_or_group O O O O O O O O O O O O O O B-multi_cell B-multi_cell O O O B-cell_line I-cell_line I-cell_line O