A naturally occurring mutation ( -175 T-C ) in the area bound by HMG-I results in overexpression of gamma-globin in adult red blood cells ( HPFH ) and up-regulation of the gamma-globin promoter in in vitro expression assays ; HMG-I does not bind to this mutant sequence .
a naturally occurring mutation ( -175 t-c ) in the area bound by hmg-i results in overexpression of gamma-globin in adult red blood cells ( hpfh ) and up-regulation of the gamma-globin promoter in in vitro expression assays ; hmg-i does not bind to this mutant sequence .
O O O B-other_name O O O O O O O O O B-protein_molecule O O O O B-protein_family_or_group O B-cell_type I-cell_type I-cell_type I-cell_type O B-cell_type O O O O O B-protein_family_or_group O O B-other_name I-other_name I-other_name I-other_name O B-protein_molecule O O O O O B-DNA_domain_or_region I-DNA_domain_or_region O