Under these conditions , etoposide produced a biphasic activation of protein kinase C , which consisted in an early transient activation ( from hours 1 to 6 ) of the membrane-bound enzyme followed by a later activation ( hour 48 ) of the total , membrane-bound and cytosolic enzyme .
under these conditions , etoposide produced a biphasic activation of protein kinase c , which consisted in an early transient activation ( from hours 1 to 6 ) of the membrane-bound enzyme followed by a later activation ( hour 48 ) of the total , membrane-bound and cytosolic enzyme .
O O O O B-other_organic_compound O O B-other_name I-other_name O B-protein_molecule I-protein_molecule I-protein_molecule O O O O O O O O O O O O O O O O O B-protein_family_or_group I-protein_family_or_group O O O O O O O O O O O O O O O O O O