We reasoned that selective IFN responsiveness of the first STAT family member ( Stat1 ) and Stat1 -dependent immune-response genes such as intercellular adhesion molecule-1 ( ICAM-1 ) , IFN regulatory factor-1 ( IRF-1 ) , and Stat1 itself in airway epithelial cells provides a basis for detecting cytokine signaling abnormalities in inflammatory airway disease .
we reasoned that selective ifn responsiveness of the first stat family member ( stat1 ) and stat1 -dependent immune-response genes such as intercellular adhesion molecule-1 ( icam-1 ) , ifn regulatory factor-1 ( irf-1 ) , and stat1 itself in airway epithelial cells provides a basis for detecting cytokine signaling abnormalities in inflammatory airway disease .
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