We further showed that Ro 09-2210 was unable to inhibit c-jun induced expression of AP1 -dependent reporter constructs ( IC50 > 500 nM ) , but was able to potently inhibit ras-induced AP1 activation ( IC50 = 20 nM ) .
we further showed that ro 09-2210 was unable to inhibit c-jun induced expression of ap1 -dependent reporter constructs ( ic50 > 500 nm ) , but was able to potently inhibit ras-induced ap1 activation ( ic50 = 20 nm ) .
O O O O B-other_organic_compound I-other_organic_compound O O O O B-DNA_domain_or_region O O O B-protein_molecule O O O O O O O O O O O O O O O O O B-protein_molecule O O O O O O O O