Briefly , we found that 1 ) rheumatoid synovial cells highly expressed CD44 ; 2 ) cross-linking of CD44 markedly but transiently augmented VCAM-1 expression and its mRNA transcription much more than did IL-1beta and TNF-alpha ; 3 ) hyaluronan , especially when fragmented , also up-regulated VCAM-1 ; 4 ) CD44 activated the transcription factor AP-1 ; and 5 ) the integrin -dependent adhesive function of RA synovial cells to T cells was also amplified by CD44 cross-linking .
briefly , we found that 1 ) rheumatoid synovial cells highly expressed cd44 ; 2 ) cross-linking of cd44 markedly but transiently augmented vcam-1 expression and its mrna transcription much more than did il-1beta and tnf-alpha ; 3 ) hyaluronan , especially when fragmented , also up-regulated vcam-1 ; 4 ) cd44 activated the transcription factor ap-1 ; and 5 ) the integrin -dependent adhesive function of ra synovial cells to t cells was also amplified by cd44 cross-linking .
O O O O O O O B-cell_type I-cell_type I-cell_type O O B-carbohydrate O O O O O B-carbohydrate O O O O B-protein_molecule O O O B-other_name I-other_name O O O O B-protein_molecule O O O O O B-carbohydrate O O O O O O O B-protein_molecule O O O B-carbohydrate O O O O O O O O O O B-protein_family_or_group O O O O B-other_name O O O B-cell_type I-cell_type O O O O B-protein_molecule O O