However , the reduced expression of these proteins was not the result of a global TCR/CD3 -signaling defect because CD3 cross-linking induced an equivalent increase in intracellular-free calcium ions , as well as NFATp dephosphorylation , translocation to the nucleus , and DNA binding in both normal and anergic T cells .
however , the reduced expression of these proteins was not the result of a global tcr/cd3 -signaling defect because cd3 cross-linking induced an equivalent increase in intracellular-free calcium ions , as well as nfatp dephosphorylation , translocation to the nucleus , and dna binding in both normal and anergic t cells .
O O O O O O O O O O O O O O B-other_name B-protein_complex O O O B-protein_molecule O O O O O O B-atom I-atom I-atom O O O O B-protein_molecule O O O O O B-cell_component O O B-other_name I-other_name O O B-cell_type O B-cell_line I-cell_line I-cell_line O