Peripheral blood T-cells exhibited significant proliferation in response to a recombinant fragment of jun-B ( amino acids 1-180 ) in 12 of 17 ( 71% ) recent-onset IDDM subjects , 8 of 16 ( 50% ) ICA-positive first-degree relatives of IDDM subjects who were at risk , 3 of 12 ( 25% ) other autoimmune disease subjects , and 0 of 10 healthy control subjects .
peripheral blood t-cells exhibited significant proliferation in response to a recombinant fragment of jun-b ( amino acids 1-180 ) in 12 of 17 ( 71% ) recent-onset iddm subjects , 8 of 16 ( 50% ) ica-positive first-degree relatives of iddm subjects who were at risk , 3 of 12 ( 25% ) other autoimmune disease subjects , and 0 of 10 healthy control subjects .
B-cell_type I-cell_type I-cell_type O O O O O O O O O O B-protein_molecule O O O O O O O O O O O O B-multi_cell I-multi_cell I-multi_cell O O O O O O O O O O O B-multi_cell I-multi_cell O O O O O O O O O O O O B-multi_cell I-multi_cell I-multi_cell O O O O O B-multi_cell I-multi_cell I-multi_cell O