Whereas in chronic myelogenous leukemia ( CML ) the granulocytes ( PMN ) were uniformly of monoclonal origin , a striking heterogeneity of clonal development was found in PMN from patients with other MPD , with up to 50% of them expressing a polyclonal pattern of X inactivation .
whereas in chronic myelogenous leukemia ( cml ) the granulocytes ( pmn ) were uniformly of monoclonal origin , a striking heterogeneity of clonal development was found in pmn from patients with other mpd , with up to 50% of them expressing a polyclonal pattern of x inactivation .
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