Both PMA and the combination of NECA and forskolin acted together either to increase ( c-Fos ) or decrease ( Jun ) protein levels as well as increasing AP-1 binding , as judged by gel-shift assay , and AP-1 transcriptional activity .
both pma and the combination of neca and forskolin acted together either to increase ( c-fos ) or decrease ( jun ) protein levels as well as increasing ap-1 binding , as judged by gel-shift assay , and ap-1 transcriptional activity .
O B-other_organic_compound O O O O B-nucleotide O B-other_organic_compound O O O O O O B-protein_molecule O O O O B-protein_molecule O B-other_name I-other_name O O O O B-protein_molecule O O O O O B-other_name I-other_name O O B-protein_molecule O O O