Transient transfections of CAT reporter gene constructs containing various Fc gamma RIC promoter sequences into U937 cells revealed that a 20-bp region surrounding the transcription start site ( -7 to +13 ) was capable of mediating transcription initiation and that an IFN-gamma responsive element ( GIRE ) was present within 74 bp upstream of the transcription initiation site .
transient transfections of cat reporter gene constructs containing various fc gamma ric promoter sequences into u937 cells revealed that a 20-bp region surrounding the transcription start site ( -7 to +13 ) was capable of mediating transcription initiation and that an ifn-gamma responsive element ( gire ) was present within 74 bp upstream of the transcription initiation site .
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