Reduction of IL-2 production is secondary to the inability to phosphorylate the cAMP response element binding protein , CREB , and induce expression of the immediate early genes such as Fos B that are required to transactivate the IL-2 promoter .
reduction of il-2 production is secondary to the inability to phosphorylate the camp response element binding protein , creb , and induce expression of the immediate early genes such as fos b that are required to transactivate the il-2 promoter .
O O B-protein_molecule O O O O O O O O O B-nucleotide O O O O O B-protein_molecule O O O O O O B-DNA_family_or_group I-DNA_family_or_group I-DNA_family_or_group O O B-DNA_domain_or_region I-DNA_domain_or_region O O O O O O B-protein_molecule O O