This defect in maturation resulted in a transgene dose-dependent reduction in peripheral T lymphocytes , with the CD8 lineage being more severely affected .
this defect in maturation resulted in a transgene dose-dependent reduction in peripheral t lymphocytes , with the cd8 lineage being more severely affected .
O O O O O O O O O O O B-cell_type I-cell_type I-cell_type O O O B-cell_type I-cell_type O O O O O