Unlike full-sized NOTCH1 , two such truncated forms of the protein either lacking a major portion of the extracellular domain ( DeltaE ) or consisting only of the intracellular domain ( ICN ) were found to activate transcription in cultured cells , presumably through RBP-Jkappa response elements within DNA .
unlike full-sized notch1 , two such truncated forms of the protein either lacking a major portion of the extracellular domain ( deltae ) or consisting only of the intracellular domain ( icn ) were found to activate transcription in cultured cells , presumably through rbp-jkappa response elements within dna .
O O B-protein_molecule O O O O O O O O O O O O O O O B-protein_domain_or_region I-protein_domain_or_region O B-protein_molecule O O O O O O B-protein_domain_or_region I-protein_domain_or_region O B-protein_domain_or_region O O O O O O O O O O O O B-protein_molecule O O O O O