Similarly , covalent modification of free sulfhydryl groups with diamide ( reversible ) or N-ethylmaleimide ( irreversible ) results in a complete loss of DNA binding activity .
similarly , covalent modification of free sulfhydryl groups with diamide ( reversible ) or n-ethylmaleimide ( irreversible ) results in a complete loss of dna binding activity .
O O O O O O B-other_organic_compound I-other_organic_compound O B-other_organic_compound O O O O B-other_organic_compound O O O O O O O O O B-other_name I-other_name I-other_name O