Results indicated that ( i ) constitutive c-fos transcript levels are significantly higher in patients subsequently responding to IFN-alpha therapy ( p < 0 . 01 ) and positively correlated with the proportion of lymphocytes ( r = 0 . 6895 , p < 0 . 01 ) and negatively with the proportion of immature cells ( r = -0 . 568 , p < 0 . 01 ) contained in the pbmc preparations tested , ( ii ) constitutive mRNA levels of the hybrid bcr/abl , c-myc and p53 are positively correlated with each other , but failed to relate to disease parameters , and ( iii ) acute and chronic in vivo exposure to IFN-alpha is accompanied by upregulation of c-fos and downregulation of c-myc mRNA levels in responder patients .
results indicated that ( i ) constitutive c-fos transcript levels are significantly higher in patients subsequently responding to ifn-alpha therapy ( p < 0 . 01 ) and positively correlated with the proportion of lymphocytes ( r = 0 . 6895 , p < 0 . 01 ) and negatively with the proportion of immature cells ( r = -0 . 568 , p < 0 . 01 ) contained in the pbmc preparations tested , ( ii ) constitutive mrna levels of the hybrid bcr/abl , c-myc and p53 are positively correlated with each other , but failed to relate to disease parameters , and ( iii ) acute and chronic in vivo exposure to ifn-alpha is accompanied by upregulation of c-fos and downregulation of c-myc mrna levels in responder patients .
O O O O O O O B-RNA_molecule I-RNA_molecule O O O O O B-multi_cell O O O B-protein_molecule O O O O O O O O O O O O O O O B-cell_type O O O O O O O O O O O O O O O O O O O B-cell_type I-cell_type O O O O O O O O O O O O O O O O B-cell_type O O O O O O B-RNA_family_or_group I-RNA_family_or_group O O O B-DNA_domain_or_region I-DNA_domain_or_region O B-DNA_domain_or_region O B-DNA_domain_or_region O O O O O O O O O O O O O O O O O O O O O O O O O O B-protein_molecule O O O O O B-other_name O O O B-RNA_molecule I-RNA_molecule O O B-multi_cell B-multi_cell O