In this study , a combined pharmacologic and genetic strategy using two PKC ( NF-kappa B ) inhibitors , pentoxifylline ( PTX ) and Go-6976 , and a stably expressed anti- Tat single-chain intracellular antibody ( sFv intrabody ) was employed to obtain cooperative inhibition of both HIV-1 LTR -driven gene expression and HIV-1 replication .
in this study , a combined pharmacologic and genetic strategy using two pkc ( nf-kappa b ) inhibitors , pentoxifylline ( ptx ) and go-6976 , and a stably expressed anti- tat single-chain intracellular antibody ( sfv intrabody ) was employed to obtain cooperative inhibition of both hiv-1 ltr -driven gene expression and hiv-1 replication .
O O O O O O O O O O O O B-protein_molecule O B-protein_complex I-protein_complex O O O B-other_organic_compound O B-other_organic_compound O O B-other_organic_compound O O O O O B-protein_molecule B-protein_molecule O O O O B-protein_molecule I-protein_molecule O O O O O O O O O B-virus B-DNA_domain_or_region O O O O B-virus O O