The mechanism of this effect is that Bcl-2 prevents the nuclear translocation of NFAT ( nuclear factor of activated T lymphocytes , a transcription factor activated by microtubule damage ) by binding and sequestering calcineurin , a calcium-dependent phosphatase that must dephosphorylate NFAT to move to the nucleus .
the mechanism of this effect is that bcl-2 prevents the nuclear translocation of nfat ( nuclear factor of activated t lymphocytes , a transcription factor activated by microtubule damage ) by binding and sequestering calcineurin , a calcium-dependent phosphatase that must dephosphorylate nfat to move to the nucleus .
O O O O O O O B-protein_molecule O O O O O B-protein_molecule O B-protein_family_or_group I-protein_family_or_group I-protein_family_or_group I-protein_family_or_group I-protein_family_or_group I-protein_family_or_group O O B-protein_family_or_group I-protein_family_or_group O O B-protein_complex O O O O O O O O O O O O O O B-protein_molecule O O O O B-cell_component O