Finally , the biological relevance of the observation that T . pallidum lipoproteins -lipopeptides induce both NF-kappa B and cytokine production in monocytes was supported by the ability of the synthetic analogs to promote human immunodeficiency virus replication in chronically infected U1 monocytoid cells ; these observations also suggest a potential mechanism whereby a syphilitic chancre can serve as a cofactor for human immunodeficiency virus transmission .
finally , the biological relevance of the observation that t . pallidum lipoproteins -lipopeptides induce both nf-kappa b and cytokine production in monocytes was supported by the ability of the synthetic analogs to promote human immunodeficiency virus replication in chronically infected u1 monocytoid cells ; these observations also suggest a potential mechanism whereby a syphilitic chancre can serve as a cofactor for human immunodeficiency virus transmission .
O O O O O O O O O B-mono_cell I-mono_cell I-mono_cell O O O O B-protein_complex I-protein_complex O B-protein_family_or_group O O B-cell_type O O O O O O O O O O O B-virus I-virus I-virus O O O O O O O O O O O O O O O O O B-tissue I-tissue O O O O O O B-virus I-virus I-virus O O