APLs with the PML-RAR alpha or the PLZF-RAR alpha fusion protein are phenotypically indistinguishable except that they differ in their sensitivity to retinoic acid ( RA ) -induced differentiation : PML-RAR alpha blasts are sensitive to RA and patients enter disease remission after RA treatment , while patients with PLZF-RAR alpha do not .
apls with the pml-rar alpha or the plzf-rar alpha fusion protein are phenotypically indistinguishable except that they differ in their sensitivity to retinoic acid ( ra ) -induced differentiation : pml-rar alpha blasts are sensitive to ra and patients enter disease remission after ra treatment , while patients with plzf-rar alpha do not .
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