The mechanism of PG490 inhibition of cytokine gene expression differs from cyclosporin A and involves nuclear inhibition of transcriptional activation of NF-kappaB and the purine-box regulator operating at the ARRE/NF-AT site at a step after specific DNA binding .
the mechanism of pg490 inhibition of cytokine gene expression differs from cyclosporin a and involves nuclear inhibition of transcriptional activation of nf-kappab and the purine-box regulator operating at the arre/nf-at site at a step after specific dna binding .
O O O B-other_organic_compound O O B-DNA_family_or_group I-DNA_family_or_group O O O B-other_organic_compound I-other_organic_compound O O B-other_name I-other_name O B-other_name I-other_name O B-protein_complex O O B-DNA_domain_or_region I-DNA_domain_or_region O O O B-DNA_domain_or_region I-DNA_domain_or_region O O O O O B-other_name I-other_name O