Microtubule disruption totally abolished the ability of exogenous 1 , 25 ( OH ) 2D3 to suppress its own synthesis and to induce 24-hydroxylase mRNA and activity , without affecting either total 1 , 25 ( OH ) 2D3 uptake or maximal 1 , 25 ( OH ) 2D3 -VDR binding .
microtubule disruption totally abolished the ability of exogenous 1 , 25 ( oh ) 2d3 to suppress its own synthesis and to induce 24-hydroxylase mrna and activity , without affecting either total 1 , 25 ( oh ) 2d3 uptake or maximal 1 , 25 ( oh ) 2d3 -vdr binding .
O O O O O O O O B-lipid I-lipid I-lipid I-lipid I-lipid I-lipid I-lipid O O O O O O O O B-RNA_molecule I-RNA_molecule O O O O O O B-other_name B-lipid I-lipid I-lipid I-lipid I-lipid I-lipid I-lipid O O B-other_name B-lipid I-lipid I-lipid I-lipid I-lipid I-lipid I-lipid B-protein_family_or_group O O