When the binding of ICSAT to four different ICSs was tested , the relative differences in binding affinities for those ICSs were determined .
when the binding of icsat to four different icss was tested , the relative differences in binding affinities for those icss were determined .
O O O O B-protein_molecule O O O B-DNA_domain_or_region O O O O O O O O O O O B-DNA_domain_or_region O O O