The requirement for TNF is further confirmed by the observation that the inability of the intermediate CD4 ( + ) CD8 ( - ) CD3 ( - ) thymocytes to replicate the virus is associated with a defect in TNF production during their interaction with TEC and correlates with the absence of nuclear NF-kappaB activity in these freshly isolated thymocytes .
the requirement for tnf is further confirmed by the observation that the inability of the intermediate cd4 ( + ) cd8 ( - ) cd3 ( - ) thymocytes to replicate the virus is associated with a defect in tnf production during their interaction with tec and correlates with the absence of nuclear nf-kappab activity in these freshly isolated thymocytes .
O O O B-protein_family_or_group O O O O O O O O O O O B-cell_type B-protein_molecule O O O O O O O B-protein_molecule O O O O O O O O O O O O O O B-protein_family_or_group O O O O O B-cell_type O O O O O O B-other_name B-protein_complex O O O B-cell_type I-cell_type I-cell_type O