T lymphocyte activation and interleukin-2 ( IL-2 ) production require at least two signals , generated by phorbol ester ( TPA ) and Ca2+ ionophore or costimulation of the T cell receptor ( TCR ) and the CD28 auxiliary receptor .
t lymphocyte activation and interleukin-2 ( il-2 ) production require at least two signals , generated by phorbol ester ( tpa ) and ca2+ ionophore or costimulation of the t cell receptor ( tcr ) and the cd28 auxiliary receptor .
B-cell_type I-cell_type O O B-protein_molecule O B-protein_molecule O O O O O O O O O O B-other_organic_compound I-other_organic_compound O B-other_organic_compound O O B-atom O O O O O B-protein_family_or_group I-protein_family_or_group I-protein_family_or_group O B-protein_family_or_group O O O B-protein_molecule I-protein_molecule I-protein_molecule O