Nevertheless , the simian EBV LMP1s retain most functions in common with EBV LMP1 , including the ability to induce NF- ( kappa ) B activity in human cells , to bind the tumor necrosis factor-associated factor 3 ( TRAF3 ) in vitro , and to induce expression of tumor necrosis factor-responsive genes , such as ICAM1 , in human B lymphocytes .
nevertheless , the simian ebv lmp1s retain most functions in common with ebv lmp1 , including the ability to induce nf- ( kappa ) b activity in human cells , to bind the tumor necrosis factor-associated factor 3 ( traf3 ) in vitro , and to induce expression of tumor necrosis factor-responsive genes , such as icam1 , in human b lymphocytes .
O O O B-virus I-virus B-protein_molecule O O O O O O O B-protein_molecule O O O O O O B-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule O O B-cell_type I-cell_type O O O O B-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule O B-protein_molecule O O O O O O O O O B-DNA_family_or_group I-DNA_family_or_group I-DNA_family_or_group I-DNA_family_or_group O O O B-DNA_domain_or_region O O B-cell_type I-cell_type I-cell_type O