Whereas different anti-CD4 mAb or HIV-1 gp120 could all trigger activation of the protein tyrosine kinases p56lck and p59fyn and phosphorylation of the Shc adaptor protein , which mediates signals to Ras , they differed significantly in their ability to activate NF-AT .
whereas different anti-cd4 mab or hiv-1 gp120 could all trigger activation of the protein tyrosine kinases p56lck and p59fyn and phosphorylation of the shc adaptor protein , which mediates signals to ras , they differed significantly in their ability to activate nf-at .
O O B-protein_family_or_group I-protein_family_or_group O B-virus O O O O O O O B-protein_family_or_group I-protein_family_or_group I-protein_family_or_group B-protein_molecule O B-protein_molecule O O O O B-protein_molecule I-protein_molecule I-protein_molecule O O O O O B-protein_family_or_group O O O O O O O O O B-protein_molecule O