Here , we report a model of CD28 costimulation using PMA plus the natural ligand CD80 that resulted in very limited stimulation of IL-2 , as evidenced by both cytokine production and IL-2 promoter stimulation .
here , we report a model of cd28 costimulation using pma plus the natural ligand cd80 that resulted in very limited stimulation of il-2 , as evidenced by both cytokine production and il-2 promoter stimulation .
O O O O O O O B-protein_molecule O O B-other_organic_compound O O B-protein_molecule I-protein_molecule I-protein_molecule O O O O O O O B-protein_molecule O O O O O B-protein_family_or_group O O B-protein_molecule O O O