The induced differentiation occurs with down-regulation of c-fos protein and an accompanying up-regulation of RB protein expression , consistent with a possible need for up-regulated RB expression to maintain a given differentiated phenotype and suppress transcriptional activators that might typically be associated with proliferation .
the induced differentiation occurs with down-regulation of c-fos protein and an accompanying up-regulation of rb protein expression , consistent with a possible need for up-regulated rb expression to maintain a given differentiated phenotype and suppress transcriptional activators that might typically be associated with proliferation .
O O O O O O O B-protein_molecule I-protein_molecule O O O O O B-protein_molecule I-protein_molecule O O O O O O O O O B-protein_molecule O O O O O O O O O B-protein_molecule I-protein_molecule O O O O O O O O