Finally , we demonstrate that a failure to degrade IkappaB-alpha in cytosols of TNF -treated T cells pretreated with PAO is due to its interference with the phosphorylation of IkappaB-alpha and not due to its inhibitory effect on proteasomal degradation .
finally , we demonstrate that a failure to degrade ikappab-alpha in cytosols of tnf -treated t cells pretreated with pao is due to its interference with the phosphorylation of ikappab-alpha and not due to its inhibitory effect on proteasomal degradation .
O O O O O O O O O B-protein_molecule O O O B-protein_family_or_group O B-cell_type I-cell_type O O B-other_organic_compound O O O O O O O B-other_name O B-protein_molecule O O O O O O O O B-other_name I-other_name O