To investigate further , we then purified a number of different kinases , including PKC , PhK , ZAP-70 , ERK , and MEK 1 ( a MKK ) , and showed that Ro 09-2210 was a selective inhibitor of MEK1 in vitro ( IC50 = 59 nM ) .
to investigate further , we then purified a number of different kinases , including pkc , phk , zap-70 , erk , and mek 1 ( a mkk ) , and showed that ro 09-2210 was a selective inhibitor of mek1 in vitro ( ic50 = 59 nm ) .
O O O O O O O O O O O O O O B-protein_molecule O B-protein_molecule O B-protein_molecule O B-protein_molecule O O B-protein_molecule I-protein_molecule O O B-protein_molecule O O O O O B-other_organic_compound I-other_organic_compound O O O O O B-protein_molecule O O O O O O O O O