Triggering of HLA class II antigens by the anti-HLA-DR monoclonal antibody ( mAb ) L243 significantly ( P < 0 . 05 ) and differentially enhanced the release of tumor necrosis factor alpha ( TNF-alpha ) by the non-Hodgkin's lymphoma cells Ri-I , Ci-I , and Sc-I , which are at a distinct stage of B-cell differentiation , and by the more mature Burkitt lymphoma cell Raji ; in contrast , it did not induce TNF-alpha release by the pre-B leukemia cells Nalm-6 and BV173 .
triggering of hla class ii antigens by the anti-hla-dr monoclonal antibody ( mab ) l243 significantly ( p < 0 . 05 ) and differentially enhanced the release of tumor necrosis factor alpha ( tnf-alpha ) by the non-hodgkin's lymphoma cells ri-i , ci-i , and sc-i , which are at a distinct stage of b-cell differentiation , and by the more mature burkitt lymphoma cell raji ; in contrast , it did not induce tnf-alpha release by the pre-b leukemia cells nalm-6 and bv173 .
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