A loss-of-function mutation in Cbl-b disrupted the interaction between Cbl-b and Zap-70 and nearly completely abrogated the Cbl-b -mediated activation of NFAT .
a loss-of-function mutation in cbl-b disrupted the interaction between cbl-b and zap-70 and nearly completely abrogated the cbl-b -mediated activation of nfat .
O B-other_name I-other_name O B-protein_molecule O O O O B-protein_molecule O B-protein_molecule O O O O O B-protein_molecule O O O B-protein_family_or_group O