A critical issue concerns the mechanism by which CD14 , which has no transmembrane domain , transduces its signal following LPS binding .
a critical issue concerns the mechanism by which cd14 , which has no transmembrane domain , transduces its signal following lps binding .
O O O O O O O O B-protein_molecule O O O O B-protein_domain_or_region I-protein_domain_or_region O O O O O B-lipid O O