Further studies indicated that inhibition of GTP-cyclohydrolase I ( an enzyme involved in de novo synthesis of an important cofactor for NOS activity , tetrahydrobiopterin ) prevented the generation of NO in A/R -tolerant cells .
further studies indicated that inhibition of gtp-cyclohydrolase i ( an enzyme involved in de novo synthesis of an important cofactor for nos activity , tetrahydrobiopterin ) prevented the generation of no in a/r -tolerant cells .
O O O O O O B-protein_molecule I-protein_molecule O O O O O O O O O O O O O B-protein_molecule O O O O O O O O B-inorganic O B-other_name O O O