Although the CRE site is necessary , optimal induction of bcl-2 expression requires participation of the upstream regulatory element , suggesting that phosphorylation of CREB alters its interaction with the upstream regulatory element .
although the cre site is necessary , optimal induction of bcl-2 expression requires participation of the upstream regulatory element , suggesting that phosphorylation of creb alters its interaction with the upstream regulatory element .
O O B-DNA_domain_or_region I-DNA_domain_or_region O O O O O O B-protein_molecule O O O O O B-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region O O O O O B-protein_molecule O O O O O B-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region O