We show here that at levels relevant to human disease , production of the human p75TNF-R in transgenic mice results in a severe inflammatory syndrome involving mainly the pancreas , liver , kidney , and lung , and characterized by constitutively increased NF-kappaB activity in the peripheral blood mononuclear cell compartment .
we show here that at levels relevant to human disease , production of the human p75tnf-r in transgenic mice results in a severe inflammatory syndrome involving mainly the pancreas , liver , kidney , and lung , and characterized by constitutively increased nf-kappab activity in the peripheral blood mononuclear cell compartment .
O O O O O O O O B-other_name I-other_name O O O O B-protein_molecule B-protein_molecule O O O O O O O B-other_name I-other_name O O O B-body_part O B-body_part O B-body_part O O B-body_part O O O O O O B-protein_complex O O O B-cell_type I-cell_type I-cell_type I-cell_type O O