To elucidate the role of retinoic acid ( RA ) in anti- CD40 + interleukin-4 ( IL-4 ) -mediated B-cell activation , the effect of 10 ( -12 ) to 10 ( -6 ) mol/L RA was studied in anti-CD40 ( 1 microgram/mL ) + IL-4 ( 5 ng/mL ) -mediated proliferation and Ig synthesis by human peripheral blood mononuclear cells ( PBMC ) and B cells in healthy donors .
to elucidate the role of retinoic acid ( ra ) in anti- cd40 + interleukin-4 ( il-4 ) -mediated b-cell activation , the effect of 10 ( -12 ) to 10 ( -6 ) mol/l ra was studied in anti-cd40 ( 1 microgram/ml ) + il-4 ( 5 ng/ml ) -mediated proliferation and ig synthesis by human peripheral blood mononuclear cells ( pbmc ) and b cells in healthy donors .
O O O O O O O O O O O B-protein_molecule B-protein_molecule O B-protein_molecule O B-protein_molecule O O O O O O O O O O O O O O O O O O B-other_organic_compound O O O B-protein_molecule O O O O O B-protein_molecule O O O O O O O B-other_name I-other_name O B-cell_type I-cell_type I-cell_type I-cell_type I-cell_type O B-cell_type O O B-cell_type I-cell_type O B-multi_cell I-multi_cell O