Three HSV/VZV recombinants were generated : ( 1 ) VZV gE protein coding sequences along with the promoter region were inserted into the thymidine kinase ( TK ) gene of HSV-1 strain KOS ; ( 2 ) VZV gE expressed from the HSV-1 ICP4 promoter was inserted into the glycoprotein C ( gC ) gene of HSV-1 strain F ; and ( 3 ) VZV IE62 protein coding sequences under the control of the HSV-1 ICP4 promoter were inserted into the gC gene of HSV-1 strain F .
three hsv/vzv recombinants were generated : ( 1 ) vzv ge protein coding sequences along with the promoter region were inserted into the thymidine kinase ( tk ) gene of hsv-1 strain kos ; ( 2 ) vzv ge expressed from the hsv-1 icp4 promoter was inserted into the glycoprotein c ( gc ) gene of hsv-1 strain f ; and ( 3 ) vzv ie62 protein coding sequences under the control of the hsv-1 icp4 promoter were inserted into the gc gene of hsv-1 strain f .
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