Although these heterodimers do not recognize a classical thyroid hormone response element ( TRE ) characterized by direct repeat separated by four nucleotides ( DR+4 ) , PPAR behaves as a dominant negative regulator of thyroid hormone ( TH ) action .
although these heterodimers do not recognize a classical thyroid hormone response element ( tre ) characterized by direct repeat separated by four nucleotides ( dr+4 ) , ppar behaves as a dominant negative regulator of thyroid hormone ( th ) action .
O O B-protein_complex O O O O O B-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region O B-DNA_domain_or_region O O O B-DNA_substructure I-DNA_substructure O O B-nucleotide I-nucleotide O B-DNA_domain_or_region O O B-protein_molecule O O O B-other_name I-other_name I-other_name O B-peptide I-peptide O B-peptide O O O