However , it was only the IL-2 promoter whose activation by Tpl-2 was fully blocked by the dominant negative mutant MEK1S218/222A and the MEK1/MEK2 inhibitor PD098059 .
however , it was only the il-2 promoter whose activation by tpl-2 was fully blocked by the dominant negative mutant mek1s218/222a and the mek1/mek2 inhibitor pd098059 .
O O O O O O B-protein_molecule O O O O B-protein_molecule O O O O O B-protein_molecule I-protein_molecule I-protein_molecule B-protein_molecule O O B-other_organic_compound I-other_organic_compound B-other_organic_compound O