We show here that the plasma cell-specific repressor function , designated SIR ( suppressor of immune response genes ) , does not act directly on the transcription of class II genes , but instead on the transcription of the AIR-1 gene , whose product , the class II transactivator ( CIITA ) , is fundamental for the regulation of the constitutive and inducible expression of MHC class II genes .
we show here that the plasma cell-specific repressor function , designated sir ( suppressor of immune response genes ) , does not act directly on the transcription of class ii genes , but instead on the transcription of the air-1 gene , whose product , the class ii transactivator ( ciita ) , is fundamental for the regulation of the constitutive and inducible expression of mhc class ii genes .
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