No significant difference was detected in the activation of MAPK kinase-1 that is induced by bufalin in wild-type or Bcl-2-overexpressed U937 cells ; however , the activation of MAPK by bufalin was significantly attenuated in the cells overexpressing Bcl-2 .
no significant difference was detected in the activation of mapk kinase-1 that is induced by bufalin in wild-type or bcl-2-overexpressed u937 cells ; however , the activation of mapk by bufalin was significantly attenuated in the cells overexpressing bcl-2 .
O O O O O O O O O B-protein_family_or_group O O O O O B-other_organic_compound O O O B-cell_type B-cell_line I-cell_line O O O O O O B-protein_family_or_group O B-other_organic_compound O O O O O O O B-protein_molecule O