However , plasma membrane-proximal elements in these proinflammatory cytokine pathways are apparently not involved since dominant negative mutants of the TRAF2 and TRAF6 adaptors , which effectively block signaling through the cytoplasmic tails of the TNF-alpha and IL-1 receptors , respectively , do not inhibit Tax induction of NF-kappaB .
however , plasma membrane-proximal elements in these proinflammatory cytokine pathways are apparently not involved since dominant negative mutants of the traf2 and traf6 adaptors , which effectively block signaling through the cytoplasmic tails of the tnf-alpha and il-1 receptors , respectively , do not inhibit tax induction of nf-kappab .
O O B-DNA_family_or_group I-DNA_family_or_group I-DNA_family_or_group O O B-protein_family_or_group I-protein_family_or_group O O O O O O O O O O O O O O O O O O O O O O B-protein_family_or_group I-protein_family_or_group O O B-protein_molecule O B-protein_molecule O O O O O O O B-protein_molecule O O B-protein_complex O