These complexes are coordinately expressed except during replicative senescence , which is characterized by the down-modulation of site beta -but not site alpha -binding activities .
these complexes are coordinately expressed except during replicative senescence , which is characterized by the down-modulation of site beta -but not site alpha -binding activities .
O O O O O O O B-other_name I-other_name O O O O O O O O B-protein_domain_or_region I-protein_domain_or_region O O B-protein_domain_or_region I-protein_domain_or_region B-other_name I-other_name O