The signal transduction events involved in gp120 -mediated enhancement of ICAM-1 appear to involve activation of both protein kinase C and tyrosine kinase , because inhibitors of protein kinase C and tyrosine kinase abrogate gp120 -mediated ICAM-1 expression in both astrocytes and microglia .
the signal transduction events involved in gp120 -mediated enhancement of icam-1 appear to involve activation of both protein kinase c and tyrosine kinase , because inhibitors of protein kinase c and tyrosine kinase abrogate gp120 -mediated icam-1 expression in both astrocytes and microglia .
O O O O O O B-protein_molecule O O O B-protein_molecule O O O O O O B-protein_molecule I-protein_molecule I-protein_molecule O B-amino_acid_monomer O O O O O B-protein_molecule I-protein_molecule I-protein_molecule O B-amino_acid_monomer O O B-protein_molecule O B-protein_molecule O O O B-cell_type O B-cell_type O