We found that expression of a constitutively active form of calcineurin could substitute for Ca2+ ionophore and synergize with PMA to activate the GM-CSF promoter , and conversely that mutant-activated Ras could substitute for PMA and cooperate with Ca2+ ionophore .
we found that expression of a constitutively active form of calcineurin could substitute for ca2+ ionophore and synergize with pma to activate the gm-csf promoter , and conversely that mutant-activated ras could substitute for pma and cooperate with ca2+ ionophore .
O O O O O O O O O O B-protein_molecule O O O B-atom O O O O B-other_organic_compound O O O B-protein_molecule O O O O O B-protein_molecule I-protein_molecule O O O B-other_organic_compound O O O B-atom O O