First , we show that mutations in the LEF-1 -binding site inhibit the activity of multimerized copies of the HIV-1 enhancer in Jurkat T cells , and that LEF-1 /GAL4 can activate a GAL4-substituted HIV-1 enhancer 80- to 100-fold in vivo .
first , we show that mutations in the lef-1 -binding site inhibit the activity of multimerized copies of the hiv-1 enhancer in jurkat t cells , and that lef-1 /gal4 can activate a gal4-substituted hiv-1 enhancer 80- to 100-fold in vivo .
O O O O O O O O B-protein_molecule O O O O O O B-DNA_family_or_group I-DNA_family_or_group O O B-DNA_domain_or_region I-DNA_domain_or_region O B-cell_line I-cell_line I-cell_line O O O B-protein_molecule O O O O B-DNA_domain_or_region B-DNA_domain_or_region I-DNA_domain_or_region O O O O O O