In transient cotransfection experiments , dominant negative mutants of the IL-1 signaling pathway , including MyD88 , IRAK , IRAK2 , and TRAF6 inhibited both IL-1 -and LPS -induced NF-kappaB -luciferase activity .
in transient cotransfection experiments , dominant negative mutants of the il-1 signaling pathway , including myd88 , irak , irak2 , and traf6 inhibited both il-1 -and lps -induced nf-kappab -luciferase activity .
O O B-other_name I-other_name O O O O O O B-protein_molecule O O O O B-protein_molecule O B-protein_molecule O B-protein_molecule O O B-protein_molecule O O B-protein_molecule O B-lipid O B-protein_complex B-protein_molecule O O