Minimizing energy studies of BMT structure reveal that a trans-disulfide of thiamine ( holo drug ) disulfide ( TDS , protodrug ) is allosterically transited to the reactive twisted disulfide of BMT ( allo drug ) by o , o'-bismyristoyl esterification of TDS .
minimizing energy studies of bmt structure reveal that a trans-disulfide of thiamine ( holo drug ) disulfide ( tds , protodrug ) is allosterically transited to the reactive twisted disulfide of bmt ( allo drug ) by o , o'-bismyristoyl esterification of tds .
O O O O B-other_organic_compound O O O O B-other_organic_compound O B-other_organic_compound O B-other_organic_compound I-other_organic_compound O B-other_organic_compound O B-other_organic_compound O B-other_organic_compound O O O O O O B-other_organic_compound I-other_organic_compound I-other_organic_compound O B-other_organic_compound O B-other_organic_compound I-other_organic_compound O O B-other_name I-other_name I-other_name I-other_name O B-other_organic_compound O