Studies presented here show that overall NF-kappa B signal transduction begins with a parallel series of stimuli-specific pathways through which cytokines ( tumor necrosis factor alpha ) , oxidants ( hydrogen peroxide and mitomycin C ) , and phorbol ester ( phorbol 12-myristate 13-acetate ) individually initiate signaling .
studies presented here show that overall nf-kappa b signal transduction begins with a parallel series of stimuli-specific pathways through which cytokines ( tumor necrosis factor alpha ) , oxidants ( hydrogen peroxide and mitomycin c ) , and phorbol ester ( phorbol 12-myristate 13-acetate ) individually initiate signaling .
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