We report that two 20-epi analogues , MC1627 and MC1288 , induced differentiation and transcription of p21 ( Waf1 , Cip1 ) , a key VDR target gene involved in growth inhibition , at a concentration 100-fold lower than that of 1 , 25 ( OH ) 2D3 .
we report that two 20-epi analogues , mc1627 and mc1288 , induced differentiation and transcription of p21 ( waf1 , cip1 ) , a key vdr target gene involved in growth inhibition , at a concentration 100-fold lower than that of 1 , 25 ( oh ) 2d3 .
O O O O B-other_organic_compound I-other_organic_compound O B-other_organic_compound O B-other_organic_compound O O O O O O B-DNA_domain_or_region O B-DNA_domain_or_region O B-DNA_domain_or_region O O O O B-protein_family_or_group O O O O O O O O O O O O O O O B-lipid I-lipid I-lipid I-lipid I-lipid I-lipid I-lipid O