Thus , changes in the Sp1 binding sites had the most dramatic effects on SIVmac replication in primary macrophage cultures .
thus , changes in the sp1 binding sites had the most dramatic effects on sivmac replication in primary macrophage cultures .
O O O O O B-protein_molecule O O O O O O O O B-virus O O B-cell_line I-cell_line I-cell_line O