The crux of transcriptional activation is how the locus control region communicates with the gene-proximal regulatory elements .
the crux of transcriptional activation is how the locus control region communicates with the gene-proximal regulatory elements .
O O O B-other_name I-other_name O O O B-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region O O O B-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region O