In the second series we observed the following : at the end of the first month of bed rest the number of glucocorticoid receptors and receptor affinity significantly increased ; at the beginning of the third month of bed rest specific glucocorticoid binding significantly decreased and circadian rhythms of adrenocorticotropin and cortisol in blood varied markedly ; at the end of the sixth month of bed rest the number of glucocorticoid receptors returned to prebed rest levels and dissociation constant decreased .
in the second series we observed the following : at the end of the first month of bed rest the number of glucocorticoid receptors and receptor affinity significantly increased ; at the beginning of the third month of bed rest specific glucocorticoid binding significantly decreased and circadian rhythms of adrenocorticotropin and cortisol in blood varied markedly ; at the end of the sixth month of bed rest the number of glucocorticoid receptors returned to prebed rest levels and dissociation constant decreased .
O O O O O O O O O O O O O O O O O O O O O O B-protein_family_or_group I-protein_family_or_group O O O O O O O O O O O O O O O O O B-other_name I-other_name O O O B-other_name I-other_name O O O B-lipid O O O O O O O O O O O O O O O O O O B-protein_family_or_group I-protein_family_or_group O O O O O O O O O O