Increased expression of IFNgamma -induced IP-10 mRNA following the differentiation of U937 cells was mediated largely by augmented transcriptional activity of the gene and was related to differentiation-dependent changes of the proteins bound to IFN stimulus response element ( ISRE ) and kB sites , suggesting that these nuclear proteins may determine the IP-10 mRNA inducibility by IFNgamma .
increased expression of ifngamma -induced ip-10 mrna following the differentiation of u937 cells was mediated largely by augmented transcriptional activity of the gene and was related to differentiation-dependent changes of the proteins bound to ifn stimulus response element ( isre ) and kb sites , suggesting that these nuclear proteins may determine the ip-10 mrna inducibility by ifngamma .
O O O B-protein_molecule O B-protein_molecule O O O O O B-cell_line I-cell_line O O O O O O O O O O O O O O O O O O O O O B-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region B-DNA_domain_or_region O O B-DNA_domain_or_region I-DNA_domain_or_region O O O O B-protein_family_or_group I-protein_family_or_group O O O B-protein_molecule O O O B-protein_molecule O