Interestingly , all of those events were largely indirect and mediated by endogenously secreted tumor necrosis factor alpha ( TNF alpha ) , as they were strongly inhibited by a neutralizing anti- TNF alpha monoclonal antibody .
interestingly , all of those events were largely indirect and mediated by endogenously secreted tumor necrosis factor alpha ( tnf alpha ) , as they were strongly inhibited by a neutralizing anti- tnf alpha monoclonal antibody .
O O O O O O O O O O O O O O B-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule O B-protein_molecule I-protein_molecule O O O O O O O O O B-protein_molecule I-protein_molecule B-protein_molecule I-protein_molecule O O O