CNI-1493 blocked neither the lipopolysaccharide ( LPS ) -induced increases in the expression of TNF mRNA nor the translocation of nuclear factor NF-kappa B to the nucleus in macrophages activated by 15 min of LPS stimulation , indicating that CNI-1493 does not interfere with early NF-kappa B -mediated transcriptional regulation of TNF .
cni-1493 blocked neither the lipopolysaccharide ( lps ) -induced increases in the expression of tnf mrna nor the translocation of nuclear factor nf-kappa b to the nucleus in macrophages activated by 15 min of lps stimulation , indicating that cni-1493 does not interfere with early nf-kappa b -mediated transcriptional regulation of tnf .
B-other_organic_compound O O O B-lipid O O O O O O O O O B-protein_family_or_group O O O O O B-protein_molecule I-protein_molecule I-protein_molecule I-protein_molecule O O B-cell_component O B-cell_type O O O O O B-lipid O O O O B-other_organic_compound O O O O O B-protein_complex I-protein_complex O O O O B-protein_family_or_group O