The lack of Jak3 expression correlated with impaired B cell signaling , as demonstrated by the inability of IL-4 to activate Stat6 in the EBV -transformed cell line from the patient . These observations indicate that the functions of gamma c are dependent on Jak3 and that Jak3 is essential for lymphoid development and signaling .
the lack of jak3 expression correlated with impaired b cell signaling , as demonstrated by the inability of il-4 to activate stat6 in the ebv -transformed cell line from the patient . these observations indicate that the functions of gamma c are dependent on jak3 and that jak3 is essential for lymphoid development and signaling .
O O O B-protein_molecule O O O O B-other_name I-other_name I-other_name O O O O O O O B-protein_molecule O O B-protein_molecule O O B-virus O O O O O O O O O O O O O O B-protein_subunit I-protein_subunit O O O B-protein_molecule O O B-protein_molecule O O O B-other_name I-other_name O O O