The cyclin-dependent kinase ( cdk ) inhibitor p21 ( WAF1/CIP1 ) has a vitamin D3-responsive element ( VDRE ) in its promoter , and 1 , 25 ( OH ) 2D3 enhances the expression of p21 ( WAF1/CIP1 ) and induces differentiation of selected myeloid leukemic cell lines .
the cyclin-dependent kinase ( cdk ) inhibitor p21 ( waf1/cip1 ) has a vitamin d3-responsive element ( vdre ) in its promoter , and 1 , 25 ( oh ) 2d3 enhances the expression of p21 ( waf1/cip1 ) and induces differentiation of selected myeloid leukemic cell lines .
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