Expression of the MAP kinase-specific phosphatase , MKP-1 , which blocks ERK activation , inhibited IL-2 promoter and NF-AT -driven transcription stimulated by a calcium ionophore and PMA , and in addition , MKP-1 neutralized the transcriptional enhancement caused by active Raf-1 and MEK1 expression .
expression of the map kinase-specific phosphatase , mkp-1 , which blocks erk activation , inhibited il-2 promoter and nf-at -driven transcription stimulated by a calcium ionophore and pma , and in addition , mkp-1 neutralized the transcriptional enhancement caused by active raf-1 and mek1 expression .
O O O B-protein_family_or_group I-protein_family_or_group I-protein_family_or_group O B-protein_molecule O O O B-protein_family_or_group O O O B-protein_molecule O O B-protein_family_or_group O O O O O B-other_organic_compound I-other_organic_compound O B-other_organic_compound O O O O O B-protein_molecule O O B-other_name I-other_name O O O O O O O O