Synergistic induction of the IL-6 gene by IFN-gamma and TNF-alpha , in monocytic cells , involved cooperation between the IRF-1 and NF kappa B p65 homodimers with concomitant removal of the negative effect of the retinoblastoma control element present in the IL-6 promoter .
synergistic induction of the il-6 gene by ifn-gamma and tnf-alpha , in monocytic cells , involved cooperation between the irf-1 and nf kappa b p65 homodimers with concomitant removal of the negative effect of the retinoblastoma control element present in the il-6 promoter .
O O O O B-protein_molecule O O B-protein_molecule O B-protein_molecule O O B-cell_type I-cell_type O O O O O B-protein_molecule O B-protein_molecule I-protein_molecule I-protein_molecule B-protein_molecule O O O O O O O O O O B-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region O O O B-DNA_domain_or_region I-DNA_domain_or_region O