A cdk2 inhibitor , Olomoucine , as well as a dominant-negative cdk2 construct prevented HLA class I -mediated inactivation of Rb ; in contrast , dominant-negative cdk4 and cdk6 constructs had no effect .
a cdk2 inhibitor , olomoucine , as well as a dominant-negative cdk2 construct prevented hla class i -mediated inactivation of rb ; in contrast , dominant-negative cdk4 and cdk6 constructs had no effect .
O B-other_organic_compound I-other_organic_compound O B-other_organic_compound O O O O O B-DNA_molecule I-DNA_molecule I-DNA_molecule O B-protein_family_or_group I-protein_family_or_group I-protein_family_or_group O O O B-protein_molecule O O O O O O O O O O O O O