In primary T lymphocytes we show that CD28 ligation leads to the rapid intracellular formation of reactive oxygen intermediates ( ROIs ) which are required for CD28 -mediated activation of the NF-kappa B / CD28 -responsive complex and IL-2 expression .
in primary t lymphocytes we show that cd28 ligation leads to the rapid intracellular formation of reactive oxygen intermediates ( rois ) which are required for cd28 -mediated activation of the nf-kappa b / cd28 -responsive complex and il-2 expression .
O B-cell_type I-cell_type I-cell_type O O O B-protein_molecule O O O O O O O O B-inorganic I-inorganic I-inorganic O B-inorganic O O O O O B-protein_molecule O O O O B-protein_molecule I-protein_molecule O B-protein_molecule O O O B-protein_molecule O O