Similarly , a kinase-deficient mutant of NIK ( NF-kappaB -inducing kinase ) , which represents an upstream kinase in the TNF-alpha and IL-1 signaling pathways leading to IKKalpha and IKKbeta activation , blocks Tax induction of NF-kappaB .
similarly , a kinase-deficient mutant of nik ( nf-kappab -inducing kinase ) , which represents an upstream kinase in the tnf-alpha and il-1 signaling pathways leading to ikkalpha and ikkbeta activation , blocks tax induction of nf-kappab .
O O O B-protein_family_or_group I-protein_family_or_group O B-protein_molecule O B-protein_complex O O O O O O O O O O O O O O O O O O B-protein_molecule O B-protein_molecule O O O B-protein_molecule O O B-protein_complex O