During normal T-cell activation , IkappaBalpha is rapidly phosphorylated , ubiquitinated , and degraded by the 26S proteasome , thus permitting the release of functional NF-kappaB .
during normal t-cell activation , ikappabalpha is rapidly phosphorylated , ubiquitinated , and degraded by the 26s proteasome , thus permitting the release of functional nf-kappab .
O O B-other_name I-other_name O B-protein_molecule O O O O O O O O O O B-protein_complex I-protein_complex O O O O O O O B-protein_complex O