Recently , cyclin E-Cdk2- and cyclin A-Cdk2- dependent phosphorylation of a single conserved serine residue ( Ser5 ) in Id2 has been shown to occur during late G1-to-S phase transition of the cell cycle , and this neutralizes the function of Id2 in abrogating E-box-dependent bHLH homo -or hetero dimer complex formation in vitro ( E . Hara , M . Hall , and G . Peters , EMBO J . 16 : 332-342 , 1997 ) .
recently , cyclin e-cdk2- and cyclin a-cdk2- dependent phosphorylation of a single conserved serine residue ( ser5 ) in id2 has been shown to occur during late g1-to-s phase transition of the cell cycle , and this neutralizes the function of id2 in abrogating e-box-dependent bhlh homo -or hetero dimer complex formation in vitro ( e . hara , m . hall , and g . peters , embo j . 16 : 332-342 , 1997 ) .
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