CONCLUSION : These results indicate that ( 1 ) IgE production in asthma and HIE usually is associated with elevated levels of IL-4 , but not IL-13 , in the peripheral blood ; ( 2 ) the increased sera IL-4 levels in asthma and HIE are not sufficient to induce Stat6 activation in PBMCs ; and ( 3 ) evidence of switch recombination to epsilon may be detected in isolated cases of elevated IgE .
conclusion : these results indicate that ( 1 ) ige production in asthma and hie usually is associated with elevated levels of il-4 , but not il-13 , in the peripheral blood ; ( 2 ) the increased sera il-4 levels in asthma and hie are not sufficient to induce stat6 activation in pbmcs ; and ( 3 ) evidence of switch recombination to epsilon may be detected in isolated cases of elevated ige .
O O O O O O O O O B-protein_family_or_group O O O O B-other_name O O O O O O O B-protein_molecule O O O B-protein_molecule O O O O O O O O O O O O B-protein_molecule O O B-other_name O B-other_name O O O O O B-protein_molecule O O B-cell_type O O O O O O O O O O B-other_name O O O O O O O O B-protein_family_or_group O