These data demonstrate that PML-RAR alpha and PLZF-RAR alpha have similar ( inhibitory ) effects on RA-independent differentiation and opposite ( stimulatory or inhibitory ) effects on RA -dependent differentiation and that they behave in vivo as RA -dependent enhancers or inhibitors of RA -responsive genes , respectively .
these data demonstrate that pml-rar alpha and plzf-rar alpha have similar ( inhibitory ) effects on ra-independent differentiation and opposite ( stimulatory or inhibitory ) effects on ra -dependent differentiation and that they behave in vivo as ra -dependent enhancers or inhibitors of ra -responsive genes , respectively .
O O O O B-protein_molecule I-protein_molecule O B-protein_molecule I-protein_molecule O O O O O O O B-other_name I-other_name O O O O O O O O O B-other_organic_compound O O O O O O O O O B-other_organic_compound O O O O O B-other_organic_compound O O O O O