In combination with TNF-alpha , IL-10 stimulated activating protein-1 ( AP-1 ) and nuclear factor ( NF ) -kappa B binding activities and cooperated to increase HIV-1 steady-state mRNA levels and enhance long terminal repeat -directed transcription through activation of the NF-kappa B binding sites , suggesting the IL-10 effect occurs at least in part at the transcriptional level .
in combination with tnf-alpha , il-10 stimulated activating protein-1 ( ap-1 ) and nuclear factor ( nf ) -kappa b binding activities and cooperated to increase hiv-1 steady-state mrna levels and enhance long terminal repeat -directed transcription through activation of the nf-kappa b binding sites , suggesting the il-10 effect occurs at least in part at the transcriptional level .
O O O B-protein_molecule O B-protein_molecule O B-protein_molecule I-protein_molecule O B-protein_molecule O O B-protein_complex I-protein_complex I-protein_complex I-protein_complex I-protein_complex I-protein_complex I-protein_complex O O O O O O B-virus O O O O O B-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region O O O O O O B-protein_complex I-protein_complex O O O O O B-protein_molecule O O O O O O O O B-other_name I-other_name O