In this study , we investigated the ability of the major envelope glycoprotein of HIV , glycoprotein 120 ( gp120 ) , to regulate intercellular adhesion molecule-1 ( ICAM-1 ) expression in glial cells , because ICAM-1 is important in mediating immune responsiveness in the CNS , facilitating entry of HIV -infected cells into the CNS , and promoting syncytia formation .
in this study , we investigated the ability of the major envelope glycoprotein of hiv , glycoprotein 120 ( gp120 ) , to regulate intercellular adhesion molecule-1 ( icam-1 ) expression in glial cells , because icam-1 is important in mediating immune responsiveness in the cns , facilitating entry of hiv -infected cells into the cns , and promoting syncytia formation .
O O O O O O O O O O B-protein_family_or_group I-protein_family_or_group I-protein_family_or_group O B-virus O B-protein_molecule I-protein_molecule O B-protein_molecule O O O O B-protein_molecule I-protein_molecule I-protein_molecule O B-protein_molecule O O O B-cell_type I-cell_type O O B-protein_molecule O O O O B-other_name I-other_name O O B-body_part O O O O B-virus O O O O B-body_part O O O O O O