Human immunodeficiency virus type 1 ( HIV-1 ) Tat , an early regulatory protein that is critical for viral gene expression and replication , transactivates the HIV-1 long terminal repeat ( LTR ) via its binding to the transactivation response element ( TAR ) and , along with other cellular factors , increases viral transcription initiation and elongation .
human immunodeficiency virus type 1 ( hiv-1 ) tat , an early regulatory protein that is critical for viral gene expression and replication , transactivates the hiv-1 long terminal repeat ( ltr ) via its binding to the transactivation response element ( tar ) and , along with other cellular factors , increases viral transcription initiation and elongation .
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