Although a role of p16 in this regulation has been presumed , there is no proof so far that loss of this tumor suppressor gene really affects E2F -mediated regulations .
although a role of p16 in this regulation has been presumed , there is no proof so far that loss of this tumor suppressor gene really affects e2f -mediated regulations .
O O O O B-protein_molecule O O O O O O O O O O O O O O O O O B-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region O O B-protein_molecule O O O