In THP-1 cells , Fc gamma R cross-linking induced NF-kappa B , which is known to bind to the regulatory region of the long terminal repeat ( LTR ) of HIV-1 and to activate HIV-1 transcription . Anti-TNF-alpha antibody but not anti-IL-1 beta antibody strongly inhibited both the induction of HIV-1 - LTR -driven transcription and the induction of NF-kappa B by Fc gamma R cross-linking .
in thp-1 cells , fc gamma r cross-linking induced nf-kappa b , which is known to bind to the regulatory region of the long terminal repeat ( ltr ) of hiv-1 and to activate hiv-1 transcription . anti-tnf-alpha antibody but not anti-il-1 beta antibody strongly inhibited both the induction of hiv-1 - ltr -driven transcription and the induction of nf-kappa b by fc gamma r cross-linking .
O B-cell_line O O B-protein_molecule I-protein_molecule I-protein_molecule O O B-protein_molecule I-protein_molecule O O O O O O O O B-DNA_domain_or_region I-DNA_domain_or_region O O B-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region O B-DNA_domain_or_region O O B-virus O O O B-virus O O B-protein_molecule I-protein_molecule O O B-protein_molecule I-protein_molecule I-protein_molecule O O O O O O B-virus O B-DNA_domain_or_region O O O O O O B-protein_molecule I-protein_molecule O B-protein_molecule I-protein_molecule I-protein_molecule O O