The consequent decrease in the nuclear levels of c-Jun and JunD leads to diminished binding of c-Jun /c-Fos and JunD /c-Fos heterodimers to the AP-1 consensus sequence in the TNF promoter and , thus , to decreased transactivation of the TNF gene .
the consequent decrease in the nuclear levels of c-jun and jund leads to diminished binding of c-jun /c-fos and jund /c-fos heterodimers to the ap-1 consensus sequence in the tnf promoter and , thus , to decreased transactivation of the tnf gene .
O O O O O O O O B-protein_molecule O B-protein_molecule O O O O O B-protein_molecule O O B-protein_molecule O O O O B-DNA_domain_or_region I-DNA_domain_or_region I-DNA_domain_or_region O O B-protein_molecule O O O O O O O O O O B-protein_molecule O O