Furthermore , there was no increase in cyclin D-associated kinase activity upon HLA class I ligation , suggesting that cyclin E-dependent kinase activity mediates Rb inactivation , leading to E2F activation and cell proliferation .
furthermore , there was no increase in cyclin d-associated kinase activity upon hla class i ligation , suggesting that cyclin e-dependent kinase activity mediates rb inactivation , leading to e2f activation and cell proliferation .
O O O O O O O B-protein_molecule I-protein_molecule I-protein_molecule O O B-protein_family_or_group I-protein_family_or_group I-protein_family_or_group O O O O B-protein_family_or_group I-protein_family_or_group I-protein_family_or_group O O B-protein_molecule O O O O B-protein_molecule O O B-other_name I-other_name O