In addition , integrin ligation leads to nuclear translocation of the p50 and p65 subunits of the NF-kappa B transcription factor , to activation of a reporter gene driven by a promoter containing NF-kappa B sites , and to increased levels of mRNAs for immediate-early genes , including the cytokine interleukin ( IL ) -1 beta .
in addition , integrin ligation leads to nuclear translocation of the p50 and p65 subunits of the nf-kappa b transcription factor , to activation of a reporter gene driven by a promoter containing nf-kappa b sites , and to increased levels of mrnas for immediate-early genes , including the cytokine interleukin ( il ) -1 beta .
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