p27Kip1 directly inhibits the catalytic activity of cyclin/cdks ( cyclin-dependent kinase ) complexes and/or interferes physically with cyclin/cdks activation by CAK .
p27kip1 directly inhibits the catalytic activity of cyclin/cdks ( cyclin-dependent kinase ) complexes and/or interferes physically with cyclin/cdks activation by cak .
B-DNA_domain_or_region O O O B-other_name I-other_name O B-protein_complex O B-protein_family_or_group I-protein_family_or_group O O O O O O B-protein_complex O O B-protein_molecule O