Recently , a multivalent guanylhydrazone ( CNI-1493 ) developed as an inhibitor of macrophage activation was shown to suppress TNF production and protect against tissue inflammation and endotoxin lethality [ Bianchi , M . , Ulrich , P . , Bloom , O . , Meistrell , M . , Zimmerman , G . A . , Schmidtmayerova , H . , Bukrinsky , M . , Donnelley , T . , Bucala , R . , Sherry , B . , Manogue , K . R . , Tortolani , A . J . , Cerami , A . & Tracey , K . J . ( 1995 ) Mol . Med . 1 , 254-266 , and Bianchi , M . , Bloom , O . , Raabe , T . , Cohen , P . S . , Chesney , J . , Sherry , B . , Schmidtmayerova , H . , Zhang , X . , Bukrinsky , M . , Ulrich , P . , Cerami , A . & Tracey , J . ( 1996 ) J . Exp . Med . , in press ] .
recently , a multivalent guanylhydrazone ( cni-1493 ) developed as an inhibitor of macrophage activation was shown to suppress tnf production and protect against tissue inflammation and endotoxin lethality [ bianchi , m . , ulrich , p . , bloom , o . , meistrell , m . , zimmerman , g . a . , schmidtmayerova , h . , bukrinsky , m . , donnelley , t . , bucala , r . , sherry , b . , manogue , k . r . , tortolani , a . j . , cerami , a . & tracey , k . j . ( 1995 ) mol . med . 1 , 254-266 , and bianchi , m . , bloom , o . , raabe , t . , cohen , p . s . , chesney , j . , sherry , b . , schmidtmayerova , h . , zhang , x . , bukrinsky , m . , ulrich , p . , cerami , a . & tracey , j . ( 1996 ) j . exp . med . , in press ] .
O O O B-other_organic_compound I-other_organic_compound O B-other_organic_compound O O O O O O B-other_name I-other_name O O O O B-protein_family_or_group O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O