Furthermore , expression of SHP-1 phosphatase which is a negative regulator of cytokine receptor signaling , was lost in most IL-2 independent cell lines ( 3/4 ) but not in the leukemic ATLL cells ( 0/3 ) .
furthermore , expression of shp-1 phosphatase which is a negative regulator of cytokine receptor signaling , was lost in most il-2 independent cell lines ( 3/4 ) but not in the leukemic atll cells ( 0/3 ) .
O O O O B-protein_molecule I-protein_molecule O O O O O O B-protein_family_or_group I-protein_family_or_group O O O O O O B-protein_molecule O O O O O O O O O O O B-other_name O O O O O