The results demonstrate that okadaic acid treatment is associated with induction of a differentiated monocyte phenotype characterized by : ( a ) growth arrest ; ( b ) increases in Mac-1 cell surface antigen expression ; ( c ) down-regulation of c-myc transcripts ; and ( d ) induction of tumor necrosis factor gene expression .
the results demonstrate that okadaic acid treatment is associated with induction of a differentiated monocyte phenotype characterized by : ( a ) growth arrest ; ( b ) increases in mac-1 cell surface antigen expression ; ( c ) down-regulation of c-myc transcripts ; and ( d ) induction of tumor necrosis factor gene expression .
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