By using PD-98059 and SB203580 , two potent and selective inhibitors of MEK1 ( a kinase upstream of ERK1/2 ) and p38 , respectively , we have demonstrated that both ERK1/2 and p38 cascades play a key role in the production of IL-8 by monocytes and PMN stimulated with bacterial fractions .
by using pd-98059 and sb203580 , two potent and selective inhibitors of mek1 ( a kinase upstream of erk1/2 ) and p38 , respectively , we have demonstrated that both erk1/2 and p38 cascades play a key role in the production of il-8 by monocytes and pmn stimulated with bacterial fractions .
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