tokens: We therefore reexamined this issue by using two different experimental approaches that allowed LMP1 -induced effects to be monitored immediately following expression of the viral protein and in the absence of selective pressures ; activation of the NF-kappa B transcription factor and upregulation of the cell adhesion molecule ICAM-1 were used as early indices of LMP1 function .
folded_tokens: we therefore reexamined this issue by using two different experimental approaches that allowed lmp1 -induced effects to be monitored immediately following expression of the viral protein and in the absence of selective pressures ; activation of the nf-kappa b transcription factor and upregulation of the cell adhesion molecule icam-1 were used as early indices of lmp1 function .
labels: O O O O O O O O O O O O O B-protein_molecule O O O O O O O O O O O O O O O O O O O O O O O B-protein_molecule I-protein_molecule B-protein_family_or_group I-protein_family_or_group O O O O B-protein_family_or_group I-protein_family_or_group I-protein_family_or_group B-protein_molecule O O O O O O B-protein_molecule O O