tokens: We demonstrate that loss of p16 causes upregulation of this DNA precursor pathway enzyme via activation of E2F by a mechanism involving retinoblastoma protein .
folded_tokens: we demonstrate that loss of p16 causes upregulation of this dna precursor pathway enzyme via activation of e2f by a mechanism involving retinoblastoma protein .
labels: O O O O O B-protein_molecule O O O O B-other_name I-other_name I-other_name B-protein_family_or_group O O O B-protein_molecule O O O O B-protein_family_or_group I-protein_family_or_group O