Prime Directive (disambiguation)
See the following articles with topics similar to Prime Directive:
 Prime Directive, the legal document
 Temporal Prime Directive, the legal document

Real world
 Prime Directive (game), a game from Star Fleet Battles
 Prime Directive (novel), the novel by Judith and Garfield Reeves-Stevens
 Prime Directive: The Official Star Trek Podcast, original title for Star Trek: The Pod Directive