Jesus Christ
Jesus Christ was a central figure in the Human religion of Christianity. According to the Bible, he was the son of God, born to a virgin named Mary, the savior of his people. The teachings of Christ, a philosophy of total love and brotherhood, would become the foundation for the Christian faith. (; ) He was also a figure in the religion of New Eden, where the inscription INRI was also used to refer to him. ()

His words were well known and occasionally quoted, for example by James T. Kirk, Spock, Montgomery Scott, Harry Mudd, Kathryn Janeway, Tom Paris, and The Doctor. (; ; )

The imperial Roman planet 892-IV began spreading the word of the "" during their 20th century. At that time, the crew of the  visited that planet, where they misconstrued it as "sun" worship. Uhura later discovered that this was not the sun in the sky, but the Son of God, prompting Kirk to muse, "Caesar and Christ. They had them both. And the word is spreading only now." ()

In Captain Janeway's  holo-program, there was a crucifix depicting Jesus Christ in Leonardo's workshop. ()

In a ward of Sisters of Hope Infirmary, a hospital in 1893 San Francisco, there was a small statue of Jesus. () 
 
Jesus' name was prone to be used as a proclamation or an intensifier. For example, upon seeing the  during his first warp flight, Zefram Cochrane exclaimed "Sweet Jesus". The same expression was used by Leonard McCoy while attempting to save Klingon Chancellor Gorkon. The phrase "for Christ's sake" was used by Douglas Pabst while stressing to Benny Russell how unbelievable the concept of a Negro captain of a space station in the future was. (; ; ) Another phrase was "thank Christ", as used by Jett Reno when she was rescued from a crashed ship after more then ten months, in 2259. ()

In an alternate timeline in 1944, Carmine said, "Jesus, he looked like some kind of demon," having come face-to-face with Ghrath. ()

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Humans
Biblical figures
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