Drug addiction
Drug addiction was the condition of being dependent on certain drugs. Voluntary addiction to drugs was a recurrent theme in many cultures. These individuals were identified as drug addicts. () 

Earth tobacco was a deadly drug capable of destroying the internal organs. It was nonetheless used because it was highly addictive. ()

In 2154, T'Pol became addicted to Trellium-D. When asked by Dr. Phlox when she realized she was addicted, she explained that two days previous, she experienced agitation, anxiety and withdrawal symptoms upon being unable to access 's supply in the cargo bay. ()

The entire Ornaran population was addicted to felicium, originally introduced as a vaccine to a plague that hit them in the 22nd century. Until the 24th century, they continued to confuse the withdrawal pains for the continued existence of this plague. ()

In 2370, a hologram of Dr. Phlox explained to  (William T. Riker) that if  hadn't agreed to Vulcan neuro-pressure treatments from T'Pol, he would've become addicted to sedatives instead. ()

The Jem'Hadar were addicted to ketracel-white as a means of control, as according to Weyoun 4, "The Founders' ability to control the Jem'Hadar has been somewhat overstated. Otherwise we never would have had to addict them to the white." () In 2372, one named Goran'Agar believed himself cured of his addiction, surmising that something about the planet Bopak III had cured him. This prompted him to ask for a stranded Julian Bashir to help him break the addiction of his fellow Jem'Hadar. In reality, his own body was secreting the drug. () Dr. Bashir's initial analysis of a Jem'Hadar youth revealed that his body was addicted to a specific isogenic enzyme, without it he would continue to experiencing a variety of symptoms associated with withdrawal, such as feeling sick when he ate or having pains in his head and . ()

In 2373, Miles O'Brien expressed his desire to wean pregnant surrogate mother Kira Nerys off caffeine rather than poisoning her with Quark's attempted decaffeinated raktajino, Quarktajino. Hearing this, Nerys complained that he made her sound like an addict. Jadzia Dax added that the major only drank two a day. O'Brien clarified that he didn't want his son to be born with a caffeine habit. ()

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Medical conditions