Acute functional dyspepsia
Acute functional dyspepsia, also known as heartburn, indigestion or sour stomach, was a condition of the upper esophageal tract becomes irritated and inflamed, causing considerable discomfort. Among other things, the condition could be caused by eating too many spicy or acidic foods. Symptoms included: burning sensation in the throat or  (sometimes described as chest pain), nausea or a foul taste in the mouth, perspiration.

Captain James T. Kirk hoped that by steering the  towards the supposed stomach area of the cosmic cloud creature, they could "give it enough indigestion" to cause it to change its course away from the planet Mantilles. ()

After repairing the  on  in 2286, Montgomery Scott mentioned in his report to Admiral Kirk that he replaced the Klingon food packs because "they was givin' me sour stomach," to which Kirk replied, "Oh, is that what it was?" ()

In 2370, during her examination of "Jayden" (Data), Talur asked him if he had experienced indigestion. ()

In 2371, Harry Kim mentioned that he couldn't drink wine after a certain time in the evening because it gave him acid heartburn. ()

Later that year, Garak commented that Julian Bashir risked indigestion by rushing his food, and proceeded to offer a sociological analysis of why Humans should eat this way when there was plenty of food for all. ()

In 2374, several of the crewmembers of the  developed acute functional dyspepsia after eating Neelix's version of Rodeo Red's Red-Hot, Rootin'-Tootin' Chili in the mess hall.  Tom Paris diagnosed it after several crewmembers complained of chest pain, and he replicated antacid to relieve their pain. ()

Soon after, when Flith suggested he and Liam Bilby have Krellan food, Bilby declined, saying the last time he had some it gave him heartburn. ()

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Medical conditions