Starbase 22
Starbase 22 was a Federation starbase administered by Starfleet. This base was located in the Beta Quadrant.

During the first , on stardate 4851.5, a cloaked Klingon raider, on a suicide mission, tailed the  into spacedock at this base, where it ignited its antimatter supply. The subsequent explosion destroyed most of the ships docked there. This assault, along with two other similar assaults at Starbase 12 and Starbase 19, resulted in the destruction of one-third of Starfleet's ships. ()

In 2259, the location of this starbase was labeled on a stellar cartography chart that was seen on the 's ready room viewscreen. () 

In 2399, the location of Starbase 22 in neutral space was labeled on a Federation star chart that was in Fleet Admiral Kirsten Clancy's office at Starfleet Headquarters. () 

In 3190, the location of Starbase 22 was labeled on a star chart used by Commander Paul Stamets for tracking the movement of the Dark Matter Anomaly through the galaxy. ()

Apocrypha
In the novel Ex Machina,  had been rebuilt by 2273 and was the first stop of the  following her encounter with V'ger.

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