Spaceflight
Spaceflight referred to transportation through space on a vehicle called a spacecraft. Some more advanced pre-warp cultures possessed limited spaceflight capabilities, although they were mostly bound to their own solar system because their space vessels were sublight, meaning they weren't as fast as the speed of light. Spaceflight was a vital component of space exploration.

Warp-capable civilizations, such as the Federation or the Klingon Empire, were capable of interstellar spaceflight, and in fact both superpowers were interstellar nations.

While underground on Minara II, Doctor Leonard McCoy made the comment that living so far underground wasn't natural. Captain James Kirk then stated "And space travel is?" ()

According to certain reports, the Sarpeidon natives did not possess spaceflight capabilities, which is why the crew of the  was surprised to find that their homeworld had been evacuated. ()

In 2285, while Spock's katra inhabited his body, giving him the appearance of madness, Doctor McCoy was attempting to charter a spaceflight to the Genesis Planet at a bar in San Francisco. When a Federation Security agent overheard his conversation, he offered to give the doctor a ride home. Dr. McCoy did not see the logic in such an offer, since he was trying to charter a spaceflight. ()

The two major planets of the Beta Renner system, Antica and , contained the major lifeforms Anticans and Selay who had become deadly enemies since achieving spaceflight. ()

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Missions and expeditions