Ophiucus system
The Ophiucus system was an inhabited planetary system in the Alpha Quadrant. Inhabited planets in this system included Ophiucus III and Ophiucus VI.

In 2256, during the first , the  routed an attack of this system by Klingon warships. (; ; )

In 2259, the location of this system was labeled on a stellar cartography chart that was seen on the 's ready room viewscreen. This system's symbol had a blue color, indicating that it was affiliated with the . () 

In 2399, the location of Ophiucus was labeled in a Federation star chart that was in Fleet Admiral Kirsten Clancy's office at Starfleet Headquarters. This system was located in or near to Federation space. () 

In 3190, the location of Ophiucus was labeled on a star chart used by Commander Paul Stamets for tracking the movement of the Dark Matter Anomaly through the galaxy. ()

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ja:オファイカス星系
Star systems