Sisko
Sisko could refer to:

People
 Benjamin Sisko, commanding officer of Deep Space 9
 , his mirror universe counterpart
 Jake Sisko, Benjamin Sisko's son, and a news reporter
 Jennifer Sisko, The first wife of Benjamin Sisko; died at the Massacre of Wolf 359
 , her mirror universe counterpart
 Joseph Sisko, Benjamin Sisko's father
 Judith Sisko, daughter of Joseph Sisko, and half-sister to Benjamin
 Kasidy Yates-Sisko, a freighter captain, and Benjamin Sisko's second wife
 Sarah Sisko, Benjamin Sisko's biological mother
 Sisko family, an overview of the family tree

Other
 Chicken à la Sisko, a chicken dish created by Benjamin Sisko
 Personal log, Benjamin Sisko, Benjamin Sisko's personal diary
 Program Sisko 197, a program to sabotage and disable all major computer systems aboard Deep Space 9
 Sisko's attack ship, the Jem'Hadar ship captured in 2373
 Sisko's Creole Kitchen, Joseph Sisko's restaurant on Earth
 Sisko's house, a home Sisko planned to build on Bajor
 Sisko's lightship, a lightship built by Sisko

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