Incurable disease
An incurable disease was a medical condition for which the cure had yet to be . An incurable disease could also be a terminal illness, but not necessarily.

In 2368, attempting to get William T. Riker to see things from a paralyzed Worf's point of view, Jean-Luc Picard asked Riker whether he would see death as a release if he were diagnosed with an incurable, terminal illness that would leave him in pain for the rest of his life. Riker felt the comparison was unfair, as Worf's condition was neither killing him or causing him physical pain. Picard explained that for Worf, his inability to handle the emotional aspects of his disability were just as debilitating. ()

Incurable conditions 
 The effects of Berthold rays ()
 David McCoy's condition (until shortly after Leonard McCoy turned off his life support system)
 Dorek Syndrome ()
 Iverson's Disease ()
 Some forms of Psoriasis (according to Tuvok's ruse) ()
 Pa'nar Syndrome (until 2154) ()
 Telurian plague ()
 Teplan blight (no cure but a preventative in future generations) ()
 Tuvan Syndrome ()
 Veridium Six poisoning ()
 Xenopolycythemia (to Federation knowledge, prior to 2268) ()
Medical conditions