Outline of application
toxicity, tumor, chemotoxic, Tumor
ADVERSE EVENTS, TUMOR, TUMOR
We have illustrated the use of continuous outcomes to indicate the degree of severity of toxicity in the context of oncology trials for finding the MTD for chemotoxic agents. One typical example is a continuous toxicity score measured based on grade information from multiple adverse events [In the following, we develop a re-design of a dose escalation trial based on a molecularly targeted endpoint, utilizing the dose-response dataset resampled from Friedman et al. [Dose-response relationship of tumor AGT activity versus Figure Tumor AGT activity (fmol/mg) of patients assigned to dose 40 Tumor AGT activity (fmol/mg) of patients assigned to dose 60 Tumor AGT activity (fmol/mg) of patients assigned to dose 80 Tumor AGT activity (fmol/mg) of patients assigned to dose 100 In the following, we employ 3PND and EWOC to determine the optimal dose of 