Study design and patients
CRS
CAVITY
SYNAPSE was a Phase III randomized, double-blind, placebo-controlled, parallel-group trial (GSK205687; NCT03085797; Additional file Patient eligibility criteria included having a diagnosis of very severe CRS, characterized by (1) the presence of recurrent, refractory severe bilateral NP symptoms, (2) ≥ 1 prior surgery for NPs (a procedure involving instruments with resulting tissue removal) in the past 10 years, and 3) a current need for surgery (defined as an overall symptoms VAS score > 7 and endoscopic NP score of ≥ 5 [maximum 8], with a score ≥ 2 in each nasal cavity). Inclusion criteria for this study resulted in patients with very severe CRSwNP [