Association of Whole-Body Hypothermia With Conventional MR Biomarkers and MR Spectroscopic Biomarkers
MR, hypothermia
Abbreviations: MD, mean difference; MR, magnetic resonance; NAA, Odds ratios (calculated as the odds of being in next highest outcome category for the hypothermia group relative to the odds of being in next highest outcome category for the control group) were reported for conventional MR imaging. MDs (calculated as cooling group values minus control group values) were reported for MR spectroscopy.Of the 285 outborn neonates, 74 died, 7 were discharged against medical advice before MR imaging, and 2 parents declined consent. The remaining 202 neonates (70.9%) received MR imaging; of those, data from 187 neonates (85 in the hypothermia group and 102 in the control group) were available for analysis. The MR imaging was performed at a median (IQR) age of 15.5 (12.2-24.0) days in the hypothermia group and 14.0 (11.0-19.0) days in the control group.Among outborn neonates, the mean (SD) absolute levels of thalamic NAA were 8.03 (1.89) mmol/kg wet weight in the hypothermia group and 7.99 (1.72) in the control group (OR, 0.05; 95% CI, −0.62 to 0.71; 