Ethics approval and consent to participate
Ethics approval for this study was provided by Research Ethics Board at Toronto Western Hospital (Approval no. 14–8710.0) and Mount Sinai Hospital (Approval no. 11–0021-E) on June 23, 2011 and June 22, 2011 respectively. The study was registered in clinicaltrials.gov NCT02152202 on 02/06/2014. The study was also done as per the declaration of Helsinki. The benefits and purposes of the study were explained to the patients, and each participant provided written, informed consent. Confidentiality was maintained at all levels of the study by avoiding identifiers and using codes to identify patients. Participants’ involvement in the study was voluntary. Participants who did not wish to participate in the study or who wished to withdraw at any time were informed that they could do so without restriction.