Introduction
death, neurodegenerative disease, Parkinson's disease, PD, white matter lesions
EVENTS, PARKINSON'S DISEASE, NEURODEGENERATIVE DISEASE
Parkinson's disease (PD) is a chronic progressive neurodegenerative disease in the elderly, which is characterized by prominent death of dopaminergic neurons in the substantia nigra pars compacta and wide spread presence of alpha synuclein, an intracellular proteinFalls are frequent and recurrent events in individuals with PD, with 45-68% of people with PD falling annually and two-thirds of them experiencing more than onceNon-pharmacological treatment, such as exercise and physical therapy, demonstrates many benefits for individuals with PD including improvements in stability and balance, gait and independenceThe Pro-kin system is designed for balance training, which provides visual feedback of center of gravity in real time, making it possible to adjust balance according to system feedback.The Pro-kin training system has been reported for the balance function treatment of individuals with white matter lesions