Statistical analysis
DEL
All analyses were performed using R statistical (version 4.1.0, R Project for Statistical Computing) and RStudio (version 1.4.1717, R Foundation for Statistical Computing) software. Descriptive statistics were undertaken using frequency and proportions for categorical variables, and median and 95% confidence interval (95% CI) for quantitative variables. Fisher's exact and Mann–Whitney This trial was approved by the institutional review board of Escuela de Medicina del Instituto Tecnologico y de Estudios Superiores de Monterrey (protocol ID: P000329‐IMAP‐CM‐CEIC‐CR003) and was reviewed by appropriate authorities of each participating center. The protocol was conducted in accordance with The Code of Ethics of the World Medical Association and informed consent was obtained from each participant prior to inclusion. The complete study protocol is available from the corresponding author upon reasonable request.