Method
Cancer
DRUG SIDE EFFECTS, CANCER
Throughout the treatment, all patients were monitored for their menstrual status. Patients with inclusion criteria who did not experience cessation of menstruation were recruited in the study. Menopausal status in the three groups was evaluated by examining the trends in serum estradiol and FSH levels as well as the changes in menopausal symptoms over a one-year period.Since all patients had normal menstruation periods before the start of the study, estradiol levels were not measured at baseline. In all three groups, serum estradiol and FSH levels were measured after 3, 6, 9, 12 months of drug administration. Menopausal symptoms and drug side effects were assessed using the Heinemann questionnaire at start of the study and the following 3, 6, 9, and 12 months.At the outset of this study, we provided patients with sufficient explanation about the procedures involved and a written informed consent was obtained from all eligible participants. We emphasized that patients could withdraw from the study whenever they wanted. The prescribed drugs were free of charge. This study was approved by the Ethics Committee of Motamed Cancer Research Institute (IR.ACECR.IBCRC.REC.1397.003).