Background
obesity, obese, TNF-α, inflammation, periodontitis, MetS, tooth, hypertension, TG
OBESITY, METABOLIC SYNDROME, INFLAMMATORY DISEASE, OBESE, FUNCTIONAL DISTURBANCE, INFLAMMATION, DISEASE, PERIODONTITIS, PERIODONTITIS, OVERWEIGHT AND OBESITY, HYPERTENSION, DISEASES, INCREASED INSULIN
Overweight and obesity increasing globally are considered major challenges to human health services [Metabolic syndrome (MetS) represents an assembly of functional disturbances including obesity, increased waist circumference, increased insulin levels/blood glucose, hypertension and/or low high-density lipoprotein (HDL)/high triglycerides (TG) count. Each is considered a risk factor for the development of other diseases [Periodontitis is a chronic non-communicable, inflammatory disease encompassing tooth supporting gingival tissues and alveolar bone triggered by dysbiosis of oral microbiota and host immune response [Elevated levels of inflammatory biomarkers including high-sensitivity C-reactive protein (CRP) [Periodontitis and MetS share inflammation as a common feature and subjects affected by either disease may display elevated levels of circulatory cytokines. Both TNF-α and IL-6 have been considered important mediators for periodontitis [The aims of the present cross-sectional study were to explore the association between obesity related variables and periodontitis, and assess if MetS is a risk indicator for periodontitis in a sample of obese adults. We hypothesize that MetS deteriorates the periodontal inflammatory status in these subjects.