Detailed overview of the qualifying and co-occurring mutational profile for individual patients.
cancer histotype, tumour, TTP
TTP, TUMOUR
Includes select clinical outcomes—best response, progression-free survival ≥ 6 months, time to progression 2 to time to progression 1 ratio, TTP2/TTP1 ≥ 1.3) by treatment group; clinical parameters—cancer histotype, no. of prior lines of treatment, prior platinum; and biomarkers of interest—genomic alteration type, tumour mutational burden, and PD-L1 status. HR homologous recombination repair, NLR neutrophil-lymphocyte ratio, PFS progression-free survival, TTP time to progression, TMB tumour mutational burden.We next used flow cytometry to assess a broad range of circulating immune biomarkers in peripheral blood at baseline, weeks 4 and 8, binned into good responders (OTR or PFS >6 months and OS ≥2 years), and poor responders. Figure 