Author contributions
MP
RECRUITMENT
MB developed the study, conceived and planned the experiments, design and wrote the article. CP, BM, and AV conceived and developed the study. MS and BV processed patient samples, performed the experiments and statistical analysis of data and contributed to the writing and revision of all drafts. IG and MVer did the PCR analyses in the standardized national laboratories. EL helped designing flow cytometry panels, analyzing flow cytometry data, interpreted results and provided feedback on the manuscript. JM and JS participated in the analysis and interpretation of the data, contributed to the writing and revision of all drafts. MJ, RC, IF, MF, MVen, GB, RM, MO, MP, and CF led recruitment, treatment, and data collection in their study centers. All authors contributed to the article and approved the submitted version.