Patient cohort
unresectable CUP
All patients provided written informed consent to the trial and to the accompanying translational research (NCT04131621; EudraCT No. 2018-004562-33). The trial was preregistered on the EU Clinical Trials Register on 22.07.2019 and on the ClinicalTrials.gov registry of the United States National Library of Medicine on 18.10.2019. The preregistered protocol version (V1.7) can be accessed under Adult patients with histologically confirmed disseminated or advanced unresectable CUP diagnosed according to the ESMO clinical practice guidelines