2.7. Secondary outcomes
PATHOLOGY, HYPERTENSION
Secondary outcomes will involve the change in DBP, mean arterial pressure, heart rate (HR), heart rate variability (HRV), 8-item Morisky medication adherence scale (MMAS-8), and 12-item health survey (SF-12) among the 3 groups at different time points.The measurement of DBP and HR will be the same as SBP, at baseline, every week, and follow-up. Mean arterial pressure indicates the function of the heart and the resistance of the peripheral aorta, and it can be calculated according to this formula:Analysis of HRV can reflect the activity, homeostasis, and associated pathology of the cardiac autonomic nervous system.The data will be analyzed in the frequency domain from a 5-minute recording, involving low frequency (LF), high frequency (HF), LF/HF ratio, total power, very low frequency, normalized low frequency (LF norm) and normalized high frequency (HF norm).The MMAS-8, consisting of 8 brief questions, is the most commonly used scale to investigate medication adherence in people with hypertension.