Author contributions
N.P., J.C., C.N., L.A.M., and M.C.A. wrote the main study protocol and designed it. B.A., N.P., and J.C. performed the data analysis. A.S.I, and R.O. conducted the molecular analysis. B.Y., C.J.A., A.S.O, E.D., M.A., G.G.P., and M.C.A. supervised the study data collections. B.Y. and A.S.O. wrote the original draft of the manuscript that was edited by A.F., H.W.S., C.A., A.D., E.M.O., N.P. and J.C. All authors read and approved the final manuscript.