PK and PD assessments
PD
Plasma samples to characterize the systemic PK profiles of anti-CTLA-4 and anti-PD-1 components of QL1706 were collected in the dose-escalation stage of phase I. The data used for establishment of the population pharmacokinetic (PopPK) model were from patients not used for the systemic PK analysis. For PD assessment, the PD-1 receptor occupancy of QL1706 on human peripheral blood CD3