Baseline data
MAY
The mean age was 15.4 years in the test group and 16.8 years in the placebo group. The most common orthodontic treatment indication was moderate-to-severe crowded dental arches and 18 patients had 2–4 premolars extracted. All the patients had pre-adjusted fixed orthodontic appliances (0.022 slot size, MBT prescription, 3M™ Victory Series™ Low Profile Brackets, Unitek, CA, USA) in the maxilla and 22 were under treatment with bi-maxillary braces. In total, three patients in each group were bonded just in the maxilla. The trial was performed during the period between February 2021 and May 2021. For various Covid-19-related reasons, only 28 subjects (21 females and 7 males) completed the study protocol, giving a dropout rate of 18%. A flow chart is presented in Flow chart of the trial according to CONSORT 2010.