Characteristics of clinical symptoms
PFAPA, fever, abdominal pain, fatigue, PFAPA syndrome, aphthous stomatitis, arthralgias, skin rashes, skin rash, pharyngitis
GENITAL ULCERATION, PERIODIC FEVER, PFAPA SYNDROME, APHTHOUS STOMATITIS, PHARYNGITIS, CERVICAL LYMPHADENOPATHY
Attacks occurred in intervals of every 4 (3–5) weeks: in boys 4 (4–5) weeks, in girls 4 (3–5) weeks (p=0.2252). The mean duration of the attack was 2.8 ± 1.2 days (boys 2.8 ± 0.98 days, girls 2.8 ± 1.3 days; p=0.9823). Complete clinical expression (present of fever and all 3 pathognomonic symptoms) was present in 50.7% of patients (54.9% boys and 46.5% girls). Periodic fever was present in 100% of patients, pharyngitis in 94.4%, aphthous stomatitis in 54.9% of patients and cervical lymphadenopathy in 91.6% of patients. Among the non-pathognomic symptoms, we noticed arthralgias in 19.7% of patients, abdominal pain in 29.6%, skin rash in 7.8%, and accentuated fatigue at the time of the attack in 16.2% of patients. In one patient, we observed genital ulceration as a possible symptom of PFAPA. We found a significant difference in the higher occurrence of skin rashes during the attack in girls than in boys (12.7% vs. 2.8% respectively; p=0.0279). Other clinical symptoms did not show a significantly different distribution between genders (Clinical presentation of PFAPA syndrome in studied patients.NS, non-significant.Percentage is calculated for individual groups by gender and for the whole group. The p-value is calculated between genders. Individual values ​​are given as average± standard deviation for parametric variables and as median (interquartile range) for non-parametric variables.