Simulated spatial transcriptomics data
To evaluate our method SpaCET, we constructed simulated (synthetic) ST data based on scRNA-seq data. For both intra- and inter-dataset validation, each simulated ST data contains 1200 spots. The simulated ST data, derived from the scRNA dataset with malignant cells, has three different malignant cell fractions, i.e., 0% (500 spots), 50% (200 spots), and 100% (500 spots). For a spot, 1–3 cell types and 3–10 cells were randomly selected from the scRNA-seq dataset using Dirichlet distribution