Study design
pulmonary embolism, allergy, knee osteoarthritis, DVT
PULMONARY EMBOLISM, ALLERGY, KNEE OSTEOARTHRITIS, DVT
This prospective, two-arm, parallel group, randomized-controlled, open-label trial with 1:1 treatment allocation was performed in a single university hospital. The study was approved by the institutional review board. (Registered on 26/02/2019, registration number 3136). Before participant enrollment, the trial was registered as a randomized controlled trial with the University Hospital Medical Information Network (Registered on 9/11/2018, registration number UMIN000034842).Patients were recruited between February 2019 and March 2021 from the patient population of a single university hospital, and eligible patients gave written informed consent. The inclusion criteria of this randomized controlled trial were patients older than 20 years with medial compartment knee osteoarthritis scheduled for MOWDTO. The exclusion criteria were as follows: previous history of DVT or pulmonary embolism (PE); patients who declared an allergy to TXA by the preoperative interview; patients scheduled for MOWDTO combined with other procedures such as implant removal, anterior cruciate ligament (ACL) reconstruction, osteochondral autograft transfer, and autologous chondrocyte implantation.