Cumulative incidence of death and effect of IA on death
death, neutropenia, leukaemia’ or’infection, AML, MDS, infection, MDS leukaemia
INFECTION, AML, NEUTROPENIA
We found that from 12 months onwards after diagnosis of AML or high-risk MDS leukaemia was the most likely cause of death. However, in the first 12 months after diagnosis of AML or high-risk MDS the probability of dying from an infection or other COD was higher than the probability of dying from another cause. By estimating the cumulative incidence with a competing risk model we were able to estimate the cumulative incidence for each COD and study the effect of prognostic factors on these CODs (’leukaemia’,’infection and other COD’, and’miscellaneous’). With regard to IA, patients with IA up until their final chemotherapy cycle had an increased risk of dying from ‘leukaemia’ or’infection and other COD’. This is in concordance with a study that reported that IA was associated with a higher risk of death in patients with AML as compared to patients without IA [The predisposing host risk factor for IA in patients with AML or MDS is prolonged and severe neutropenia [