Data generating mechanisms
We use the data generating mechanisms described by Freidlin et al.Comparison of type I error rates for tests based on different summary measures in proportional hazards non-inferiority scenarios.DRMST(3): difference in restricted mean survival time to 3 years, DS(3): difference in 3-year survival probability, HR: hazard ratio, PH: proportional hazards, S(3): 3-year survival.Monte Carlo standard errors can be computed as Comparison of power for tests based on different summary measures in proportional hazards non-inferiority scenarios.S(3): 3-year survival probability; PH: proportional hazards; HR: hazard ratio; DRMST(3): difference in restricted mean survival time to 3 years; DS(3): difference in 3-year survival probability.Monte Carlo standard errors can be computed as Scenario where type I error was >3%.For all scenarios, we simulate 10,000 repetitions, which should give a Monte Carlo standard error around 0.15% for type I error and below 0.5% for power across scenarios.