INTRODUCTION
toxicity
ONCOLOGY, ADVANCED CANCER
Despite progress over the past few decades, most individual treatments for advanced cancer are associated with modest survival benefits (often < 2 months as median).We have previously extracted and compared the time toxicity in clinical trials using trial publications and protocols.Clinical trials, the gold standard to prospectively assess and compare efficacy, provide a unique opportunity to compare the time toxicity of treatments. Oncology clinical trials already collect vast amounts of data. Cooperative group trials additionally often collect measures of resource utilization.