Discussion
lupus disease, mucocutaneous
OXIDATIVE STRESS, CARDIOVASCULAR DISEASE
In the present study, the lupus disease activity revealed a significant decrease 3 months after treatment with NAC. General, mucocutaneous, neurological, musculoskeletal, renal, and vascular symptoms showed a significant improvement in the NAC group. While the anti-dsDNA, ANA, C3, and C4 levels had no significant difference between the two groups after the treatment, CH50 had a significant increase in the NAC group. The findings were consistent with other studies [The oxidative stress contributes significantly to the development of cardiovascular disease [Additionally, the NAC as an adjuvant and a precursor to glutathione can improve lupus disease's clinical outcomes [