Statistical analysis
SECONDARY
The Statistical analysis was conducted with the SPSS 20.0 package (IBM, Armonk, New York) according to an intention to treat approach. The mean and standard deviation were calculated for each variable. To examine at baseline between group differences patient’s characteristic one-factor ANOVA or Mann Whitney-U test following the normally or non-normally distributed data and Chi-Square test was used. To determine the normal distribution of quantitative data the Kolmogorov-Smirnov test was used.Linear mixed-model with repeated-measures were analyzed, the intervention effect over time were modeled to primary and secondary outcome measures, the significant level was set at (p < 0.05) The normal distribution of residuals was analyzed prior to carrying out the analysis. The random effects were modeled on individuals, and the fixed model on groups (Control group and Intervention group), time (Baseline, postintervention, and one-month follow-up) and group x time. All participants were included at the analysis because the mixed-model estimates values for missing data [