Outcome justification
aggressive intravascular fluid, STEC infections
The rationale for selection of the MAKE30 as the primary outcome is twofold: (1) the kidneys are the major target organ through which STEC infections cause adverse outcomes and (2) the kidneys are the organ system most likely to benefit from the proposed intervention. Several prior cohort studies demonstrated that RRT use, a component of the MAKE30, is reduced with the use of aggressive intravascular fluid administration in STEC-infected children [