Limitations
vessel failure
TARGET-FFR was a single-center study with a relatively homogeneous PCI practice, including high rates of lesion predilatation and high-pressure stent postdilatation. A larger multicenter trial incorporating a wider range of PCI strategies and techniques may have had a different outcome. The study was not powered for clinical outcomes and the incidence of target vessel failure at a median follow-up of 3 years remained low.