Interventions
organ dysfunction
At inclusion (before treatment administration), the organ dysfunction severity was evaluated with the SOFA score together with an assessment of plasma concentrations of selected amino acids (arginine, citrulline, glutamate, glutamine, ornithine, proline, and tryptophan (and kynurenine)), interleukin-6 (IL-6), and monocytic human leukocyte antigen-DR expression (mHLA-DR). The same evaluation was repeated on day 3 (during treatment) and on day 7 (after treatment).