1. Introduction
obesity, obese, overweight
OBESITY, OBESE
These authors contributed equally to this work.Exosome release varies depending on the physiological state of the cell, so they could play a fundamental role in obesity, the biggest pandemic in today’s societies. The beneficial effects that physical activity has both on weight and cardiovascular parameters may be mediated by exosomes released in response to exercise. Thus, we aimed (I) to study the influence of a 12-week CT intervention on exosome cargo modifications in men with obesity and (II) to determine whether changes in exosomes after the intervention were related to changes in cardiometabolic health parameters in our cohorts. An experimental, controlled design was performed in twelve (nine with valid data) adult male obese patients (mean values: 41.6 years old, 97.6 kg and 32.4 kg/mThe worldwide prevalence of obesity has almost tripled in the last 40 years, with 39% and 13% of adults now considered to be overweight and have obesity, respectively [Adipose tissue releases a wide range of adipokines as indicators to the organs of the functional status [The benefits of exercise on health and obesity are well-recognized and identified across many organ systems [To the best of our knowledge, there is a lack of studies in obese persons addressing the effects of CT intervention (chronic exercise) not only on cardiometabolic health parameters (cardiovascular score), but also on exosome changes in obese populations. Therefore, we hypothesized that the well-known beneficial effect of CT in obese (weight and fat losses or reduction of blood pressure and cardiometabolic risk score) [