Pharmacokinetics
Plasma was isolated from whole blood collected pre-treatment and at 1.5, 2.5, 4, 8, 10 and 24 h post-FOLFIRI infusion, at cycle 1 day and cycle 3 day 1. The mean AUC (0-t) for AZD8931 at 20 mg bd was 11,395.5 and 12,493.78 ng/mL, at 40 mg bd was 20,795.4 and 22,864 ng/mL, at 80 mg bd was 55,156.75 and 72,049.15 ng/mL and at 160 mg bd was 137,221.39 and 185,184.96 ng/mL, when AZD8931 was administered without and with FOLFIRI, respectively. The mean AUC (0–