Rs9984273 is associated with COVID-19 hospitalization
ARDS
DISEASE PROGRESSION, DISEASE, ARDS, MINOR
Adhering to our recent clinical and laboratory findings, and the outbreak of the SARS-CoV2, we also explored the role of rs9984273 in COVID-19 through publicly available databases. After all, without a doubt both endogenous and exogenous type I IFNs and steroids play a fundamental role in disease progression and survival concerning COVID-19. Recent genome-wide analyses of COVID-19 patients have revealed that SNP rs2236757 in IFNAR2 has a significant impact on disease severity [Associations of rs9984273 C allele* to disease severity of COVID-19 in meta-analyses*The patients with CC/CT vs TT were compared**Total number of cases and controls. Subjects involved in the calculation were 679 (distribution of cases and controls used in the calculation was not given in the original data)We also tested, whether carrying the minor alleles of rs9984273 C and rs2236757 A, correlated with mortality in our ARDS cohort. We found that patients possessing the minor alleles for both genotypes have significantly decreased mortality than those homozygous with the major allele for both genotypes. The lower mortality among the minor allele carriers (