Methylphenidate normalizes aberrant state dynamics in children with ADHD
TD, ADHD
Next, we tested whether methylphenidate could normalize abnormal state dynamics in children with ADHD. A two-way ANOVA with factors medication (placebo, methylphenidate) and state (S1, S2, S3, S4 and S5) revealed a significant main effect of state (Because the occupancy rate of state S2 was significantly different between children with ADHD under placebo and TD children, we further specifically tested whether medication normalizes the occupancy rate of S2 in children with ADHD. A pairwise These results suggest that methylphenidate administration reduces aberrant latent brain states associated with cognitive control systems in children with ADHD, normalizing them to levels observed in TD children.