2.13. Statistical Analysis
SECONDARY
Data will be analyzed in STATA 17 (StataCorp, College Station, TX, USA). Primary analyses will be according to intention-to-treat (ITT) principle with multiple imputations or other appropriate statistics. Additional prespecified analyses will be undertaken that include completers and the per-protocol analyses. Repeated measures mixed effect models will be used to assess changes in the family of primary outcomes (gut microbiota beta-diversity (weighed UniFrac distance) and mean glucose iAUC (75 g OGTT)) between the groups and in our secondary outcomes (waist circumference, body weight, FPG, 2 h-PG and Matsuda ISI