Statistical analysis
Continuous variables following a normal distribution, as age, are presented as mean and SD and mean differences were analyzed by the Student T test. Continuous variables that did not follow a normal distribution, such as lesion size, are presented as median and interquartile range (IQR). Differences were analyzed by the Mann-Whitney test followed by the post Dunn test. The difference in proportions were analyzed using the Fisher exact test. The GraphPad Prism was used to perform the statistical analysis. The Kaplan-Meier survival curve was performed to compare the healing time proportion in the two groups and the log-rank test was used to compare the curves.