Discussion
obesity, Hyperleptinemia, cardio - metabolic disease
OBESITY, CHRONIC HEART FAILURE, INSULIN RESISTANCE
Our results, in a Free fatty acids generated during lipolysis are important intracellular signaling molecules inhibiting leptin secretion. Yet, the effect has been shown to involve leptin transcription (While the reduction in leptin levels was detected within 135 minutes ANP levels are reduced in patients with obesity (Interestingly, cross sectional studies in patients with chronic heart failure, a condition with elevated ANP and BNP concentrations, have shown increased leptin levels (Hyperleptinemia and leptin resistance are a common finding in patients with obesity and insulin resistance, and a reduction in circulating leptin levels has been suggested recently to be an effective way to increase leptin sensitivity and restore its functional homeostasis in hyperleptinemic individuals, resulting in anti-obesogenic and antidiabetic effects (Limitations of our analysis include the small sample size consisting of male participants, the While ANP has already been implicated in a number of metabolic functions, a physiological link to leptin regulation further highlights the important role of this cardiac hormone in metabolic regulation and validates this facet of the heart - adipose axis. Given the well-established blood pressure-lowering, heart failure-protective and beneficial metabolic effects of ANP, agonists of the ANP system appear to be ideal targets for combating cardio - metabolic disease.