Author contributions
H.H. and M.N. conceived the research idea and designed the study; K.W. performed the clinical study; K.W. and T.P.M.S. processed the samples in the laboratory; P.A.dJ., K.W. and I.A. performed data analysis; K.W. and P.A.dJ. wrote the first draft of the manuscript; All authors contributed to manuscript revision, read and approved the submitted version.