5. Conclusion
HYDROXYAPATITE
The results of this long-term double-blinded, randomized clinical trial in adults clearly show the non-inferiority of the fluoride-free hydroxyapatite toothpaste to the toothpaste with 1,450 ppm fluoride with regard to the primary endpoint DMFS index. According to the per-protocol analysis, no increase in DMFS index was observed in 89.3% of subjects of the hydroxyapatite group and 87.4% of subjects of the fluoride group. In conclusion, hydroxyapatite was proven to be a safe and efficient anticaries agent in oral care.