ROI segmentation and feature extraction
fracture
OSTEOSCLEROSIS
The zone with abnormal density, such as osteosclerosis, cystic change, and subchondral bone fracture, is defined as the region of interest (ROI). These ROIs were manually segmented and outlined in coronal, sagittal, and axial positions in the bone window (window width 1500HU, window level 400U) by a senior radiologist (**) and a senior orthopedic surgeon (**) to produce 3D ROIs (Fig. 