CDA, PIRA, and RAW in ocrelizumab-treated patients
Disability
EVENTS, CDA, REMISSION, EVENT
Of the 97 patients included in the analysis, 23 (23.7%) experienced CDA, i.e., a confirmed increase in EDSS according to the definition laid out in the methods section. Three patients had a RAW event (3.1% of the total population of 97 patients, three patients one relapse each), and 20 patients had a PIRA event (20.6% of the analyzed 97 patients). As depicted in Fig. Disability change. In order to visualize EDSS changes, the total cohort (n = 97) was stratified into four groups: "stable" are patients without EDSS worsening (n = 71), "RAW" were patients with relapse-associated worsening in EDSS (n = 3), "PIRA -SIR" were patients with progression independent of relapses without superimposed relapses (n = 16), "PIRA + SIR" were PIRA patients with superimposed relapses (n = 4). There were no patients with a combination of PIRA and RAW in the cohort (i.e., no superimposed relapses altered the EDSS in any patient). n = 3 patients experienced relapses with complete remission, i.e., without detectable long-term EDSS worsening, and are depicted as blue dots within the stable group. EDSS worsening was defined as an increase of 1.0 EDSS points if the previous EDSS was ≤ 5.5 or 0.5 EDSS points if the previous EDSS was > 5.5 and if the new EDSS was confirmed at least 12 weeks thereafter. Significance was calculated using Kruskal–Wallis test and Dunn's multiple comparison test. *Figure Kaplan-Meyer-estimates of CDA events in real-world ocrelizumab cohort. The figure depicts the probability of patients having experienced RAW or PIRA events in the observed cohort over time. CDA shows the probability of at least one of the two having occurred. Table 