Randomization.
obesity, cardiovascular disease, diabetes
OBESITY, CARDIOVASCULAR DISEASE, CHRONIC RESPIRATORY DISEASE, HYPERTENSION, DIABETES
A stratified block randomization with age (<60 years versus ≥60 years) and the presence of risk factors (any versus none of cardiovascular disease, chronic respiratory disease, hypertension, diabetes, obesity, or smoking) as the stratification factors was used. Subject randomization codes were generated by an independent statistician using Statistical Analysis Software (SAS) version 9.4 (SAS Institute, Inc., Cary, NC, USA), and subjects were assigned to the treatment groups by the investigators via an interactive web-response system.