Acknowledgements
The funders did not play a role in the study design, collection, analysis, and interpretation of the data nor in the writing of or decision to submit this manuscript.Bayer AG provided aspirin and matching placebo for ASPREE. The authors acknowledge the dedicated and skilled staff in Australia and the United States for the conduct of the trial. The authors are also most grateful to the ASPREE participants who so willingly volunteered for this study and the general practitioners and medical clinics that supported the participants in the ASPREE study.