4.2. Synchrony
migraine, CM, TOD, migraines
MIGRAINE, MINOR, MIGRAINES
After analyzing the effect of TOD on exercise, we subsequently classified both exercise times as in-sync or out-of-sync with chronotype to adjust for preference. Interestingly, adherence to the exercise prescription during IS exercise was significantly higher than OOS exercise. To our knowledge, this is the first study to evaluate adherence to an exercise program for people with CM in this way and represents a clinically impactful tool to improve exercise prescription. These findings suggested that people with CM are more likely to comply with an exercise prescription if the exercise is prescribed at a time befitting their temporal preference. Previous studies have shown that people who adhere to exercise are able to manage their migraines in a more capable and confident manner [When evaluating migraine burden, only IS exercise was capable of eliciting improvements, while OOS exercise had no effects. MIDAS scores improved after the month of IS exercise, but scores slightly increased after OOS exercise, with the same pattern being observed in HIT-6. Additionally, the number of migraine days experienced during the month of IS exercise decreased compared to baseline, while a minor increase was seen during OOS exercise. To our knowledge there are no previous studies investigating the effects of IS or OOS exercise 