Study timeline.
SCES, EAW
Timeline of study phases for NCT04782947. After baseline outcome measures are assessed, temporary implantation occurs followed by 5 days of mapping. After removal of the temporary implant, participants are given 2 weeks rest and then receive the permanent implant. Permanent implant mapping occurs for 2 weeks, focusing mainly on voluntary limb movement and extensor activity to facilitate standing. Following this, phase I of the study begins, consisting of 24 weeks training 3 days per week. Each training day consists of one hour of spinal cord epidural stimulation (SCES) combined with exoskeleton-assisted walking (EAW), followed by one hour of SCES combined with standing task-specific training (StTST). After 1 week of re-assessing outcome measures (Post-assessments 1), 4 weeks of re-mapping is conducted to optimize standing, and walking function for the next phases of the study. Following this, phase II of the study begins, consisting of 24 weeks of the same training as phase I. In the final week of the study, outcome measures are re-assessed a final time (post-assessments 2).