Software
REGRESSION
For PopPK modeling, analyses were performed using nonlinear mixed effects modeling methodology as implemented in the NONMEM software system, version 7.3 (ICON Development Solutions, Ellicott City, MD). For exposure–response analysis, time-to-event analyses were performed using the Cox proportional hazards regression (PHREG) procedure within SAS (version 9.4). Graphical analysis of the data or output from the models was performed using R software (version 3.6.1).