Sample size
diabetic macular edema
DIABETIC MACULAR EDEMA
The sample size was carried out using G*Power 3 software. A calculated minimum sample of 60 patients with diabetic macular edema was needed. However, to avoid missed or lost to follow-up patients, we enrolled 70 patients (divided into two groups, each of them including 35 patients). Group (I) received ranibizumab intravitreal injection, and group (II) received ranibizumab intravitreal injection plus additional topical bromfenac 0.09% twice daily for six months.