Results
A total of 124 candidates were screened for eligibility (Fig. 
Consolidated Standards of Reporting Trials (CONSORT) flow-chart diagram of the study. Abbreviations: 0.1% loading dose, group receiving 0.1% for the first six months followed by 0.01% for 18 months; 0.01%, group receiving 0.01% for 24 months; N, Number