Introduction
cerebral demyelination, Mesenchymal stem cells, toxicity, long-term disability, neuronal degeneration, neurological deficits, disability, non-traumatic
DEGENERATION, INFLAMMATION, DISEASE, DISEASE MODELS, EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS (EAE), DEMYELINATION, MULTIPLE SCLEROSIS (MS)
Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system (CNS) characterized by inflammation, multifocal demyelination, and neuronal degeneration. MS is the most common non-traumatic cause of disability in young adults and the incidence has increased over the past decades [Remyelination, which may restore saltatory axon potential conduction and prevent axonal degeneration, frequently fails in patients with MS. As the disease progresses, lack of myelin and neuronal degeneration results in neurological deficits and long-term disability [Mesenchymal stem cells (MSCs) exhibit self-renewal potential and have multipotent properties [Previous studies have shown that MSCs may have neuroprotective properties [MS occurs exclusively in humans, but different aspects of the disease may be mimicked in disease models. The two most common experimental models for MS in rodents are the cuprizone model and the experimental autoimmune encephalomyelitis (EAE) model. The cuprizone model has the advantage of inducing cerebral demyelination via toxicity to oligodendrocytes without major involvement of the adaptive immune system [