Treatment
cancer
CANCER
This phase I trial utilized a standard 3+3 dose escalation schema. Four dose levels were evaluated with a cycle defined as a period of 28 days. The dose of riluzole was kept constant at 100 mg PO twice a day (BID). While a dose-escalation phase I trial was not performed with riluzole in cancer patients, we chose the 100 mg BID dose based on the evidence of biologic activity and overall safety in our phase 0 and Phase II trials at 100 mg BID [