Imaging assessments
Computed tomography (CT) of the brain followed by CT angiography from aortic arch to the vertex and CT perfusion was performed on D0. Automated perfusion maps (RAPID) were used to measure the core and penumbra (Tmax). Magnetic resonance imaging (MRI) with DWI and FLAIR sequences was performed on D3 and D9. The volume of hyperintense lesion on FLAIR sequences was measured by a prediction algorithm using an open source toolbox which has high reproducibility compared to expert manual lesion marking [