Consideration of alternative trial designs
seizures, epilepsy
EPILEPSY
With failure to recruit to our randomised controlled factorial trial, we needed to consider how to take our programme of work forward. Potentially core to our failure to recruit is the fact that ASMs do not generally modify the natural history of epilepsy but aim to prevent the occurrence of seizures and consequent harm. There has been only one placebo-controlled paediatric RCT of ASMs in RE [