Objectives {7}
toxicity, PEx
The primary objective of the PEx cohort is to identify the effectiveness, or comparative effectiveness, of alternative interventions that are currently in routine use, or proposed for future use, in the management of PERITs in children and adults with CF, with respect to short-term improvements in lung function. For the purpose of the PEx cohort, “intensive therapy” means therapy comprising the initiation of at least one antibiotic by the intravenous route.Secondary objectives are to identify the effectiveness, or comparative effectiveness, of alternative interventions on:Long-term improvements in lung functionShort and long-term improvements in symptoms, quality of life (QoL) and life expectancyShort and long-term healthcare utilization, including for management of PERITsThe toxicity and comparative toxicity of alternative interventionsThe cost-effectiveness of alternative interventionsThe impact of alternative interventions on the generation or selection of antibiotic resistant bacteria and the impact of this on lung function and QoL