2.1. Efficacy
PD, SD
DISEASE
Of the 47 patients, 42 (89.4%) had at least one radiological evaluation after regorafenib administration. None of the patients experienced a complete response (CR); three (7.1%) had a partial response (PR), 17 (40.5%) had stable disease (SD), and 22 (52.4%) had progression of disease (PD) as their best response. The resulting objective response rate (ORR) and disease control rate (DCR) were 7.1% and 47.6%, respectively. Five patients were not evaluated as they discontinued treatment prior to their first radiological assessment (see Out of the 47 patients included in the analysis population, 37 (78.7%) provided a biopsy sample before regorafenib administration. Of these 37, three patients underwent post-regorafenib therapy biopsies, none from the same lesion as the pre-biopsy sample. Overall, a total of 40 biopsies were collected, and the majority (29, 72.5%) were collected from the liver. Lesion response was measured on pre-biopsy samples from 28 patients and on pre- and post-biopsies from different lesions from 3 patients. Each lesion’s response was objectively assessed as described in 