Subjects
This randomized controlled trial was conducted from January 2021 to June 2022 in the Department of Oral Surgery, Hospital of Stomatology, Wuhan University. The study followed the Declaration of Helsinki on medical protocol and ethics, and the study was approved by the Regional Ethical Review Board of the Ethics Committee of the Hospital of Stomatology, Wuhan University (No. 2020B72). The trial was also registered on the Chinese Clinical Trials Registry on 19/11/2020, with the registration number: 2000040063.The trial design is parallel, and the allocation ratio is 1:1. There were no significant changes to both methods after the trial commencement.