Introduction
deaths, infections, ARDS
COVID-19 (CORONAVIRUS DISEASE 2019), VIRUS, ARDS, INFECTIONS
The Coronavirus Disease 2019 (COVID-19) pandemic caused by the SARS-CoV-2 virus has inflicted a significant health burden. As of September 2023, there were more than 770 million confirmed infections with 6.9 million deaths worldwidePulmonary surfactant, synthesized and secreted by alveolar type II cells (AT-II), consists of a unique mixture of biomolecules (phospholipids, proteins, and cholesterol) and has a specific biophysical property that lowers alveolar surface tension during expirationEffective exogenous surfactant delivery to improve the alveolar epithelial barrier function remains challenging in adults. Previous replacement studies of nebulized surfactant in ARDS were limited by poor alveolar deposition