INTRODUCTION
metabolic inflexibility, overweight, metabolic dysfunction
OBESE, DISEASE
According to the Centers for Disease Control (CDC), more than 42% of adults are classified as obese, and approximately 74% of US adults are classified as overweight (body mass index of 25.0 to <30 kg/mObesity is associated with physiological disruption, specifically metabolic dysfunction such as impaired ability to use fat or metabolic inflexibility (Kelley et al., More recent work on short‐term (1–2 weeks) CR (700–1000 kcal/d intake) in Ow or Ob women suggests improved body weight and body composition CR (Jakobsdottir et al., Accordingly, the purpose of this single‐arm trial was to document the effects of a 3‐day very low‐calorie CR diet (<600 kcal/d) on body weight/composition, measures of cardiometabolic health as well as circulating regulatory factors that regulate hunger, satiety, and metabolism. We hypothesized that the 3‐day CR diet would induce favorable changes in body weight, body composition, metabolic function, via increased fat use, blood pressure, and blood glucose/lipid profile. This study could provide evidence on the acute efficacy of a novel 3‐day CR on body weight/composition, but also identify the potential underlying physiological mechanisms through which such dietary intervention may elicit cardiometabolic improvement. Collectively, this may provide a preliminary data for study of this diet with IF.