Conclusions
In open clinical studies, minimizing information bias represents a significant challenge. Our findings indicate that implementing blinded evaluations can effectively reduce information bias, thereby ensuring the authenticity and reliability of trial outcomes. We strongly advocate for the appointment of an independent blinded researcher at each trial site and the implementation of a series of standard operating procedures (SOPs) for blinded evaluations. For this purpose, we propose a comprehensive set of SOPs encompassing divisions of labor among researchers, subject management, collection of efficacy and safety indices, and trial drug management. By doing so, we aim to achieve effective blinded evaluations and enhance the quality of open trials to the greatest extent possible.Importantly, our study provides a practical strategy for future clinical trials to mitigate potential biases, thereby strengthening the evidence base for clinical decision-making.