Other clinical outcome assessment (COA) instruments
Depression, Dementia
To be able to assess the range of psychometric properties of the ADCS-ADL-MCI as detailed further below, several additional COA questionnaires were used that had been completed by patients, their caregivers, or clinicians at various time points. These questionnaires included the Global Deterioration Scale (GDS), the Informant Beck Depression Inventory (BDI), the NYU Delayed Paragraph Recall Test, and the Symbol Digit Modalities Test. Further, the Clinical Dementia Rating – Sum of Boxes (CDR-SB), the 11-item Alzheimer's Disease Assessment Scale – Cognitive Subscale (ADAS-Cog), and the Mini-Mental-State Examination (MMSE) were collected at screening and months 6, 12, 18, 24, and 36, while the Quality of Life – Alzheimer's Disease (QoL-AD) was assessed at baseline and months 6, 12, 24, and 36. Finally, the Mild Cognitive Impairment – Clinician Global Impression of Change (MCI-CGIC) was assessed at months 6 and 12, while 