Intervention
psychosis
INFLAMMATION
Single intravenous infusion of tocilizumab (4.0 mg/kg; max 800 mg in total) or normal saline given to participants with psychosis and evidence of inflammation. Tocilizumab blocks both IL-6 classic and trans-signalling—the latter being responsible for most of the inflammatory effects of IL-6—providing broad inhibition of IL-6 signalling and a strong test of a casual role for IL-6 in psychosis.