Conclusion
T2D
TYPE 2 DIABETES
In adults with T2D, pre-meal WP reduced PPG by coordinating an enhancement in β-cell function with a reduction in insulin clearance. This enabled an efficient postprandial insulinemic profile to be achieved without requiring further β-cell stimulation.Trial registry ISRCTN ID: ISRCTN17563146
For most people with controlled type 2 diabetes (T2D), controlling postprandial glycemic (PPG) excursions are fundamental to achieving optimal glycemic control (Nutritional therapies are central to the care of T2D (It is well appreciated that major determinants of PPG include the rate of gastric emptying and the secretion of insulin (While much research has focused on the gastrointestinal responses following pre-meal WP supplementation, its effects on insulin kinetics and β-cell function remain unknown. We, therefore, examined the mechanisms by which pre-meal WP reduces PPG in people with T2D using a validated model of insulin kinetics and β-cell function. It was hypothesized that a pre-meal WP bolus would amplify the secretion of insulin, while modestly reducing the metabolic clearance rate of insulin (MCRi) (