Introduction
deaths, human infection
TYPHOID FEVER, TYPHOID, TYPHOID FEVER
Typhoid fever is an urgent public health problem in resource-limited regions of the world, causing approximately 10.9 million cases and 100,000 deaths annually (Typhoid conjugate vaccines have emerged as an effective method of controlling typhoid fever. We have previously described the efficacy of Vi–polysaccharide–tetanus toxoid glycoconjugate vaccine (ViTT, also known as ViTCV) in a controlled human infection model (CHIM) study (Glycoconjugate vaccines are more immunogenic than plain polysaccharide vaccines and, importantly, are able to confer protection in infants and children (