Ethics approval and consent to participate
The study shall be conducted according to the principles of the Declaration of Helsinki (version 10.2013) and in accordance with the Medical Research Involving Human Patients Act (WMO), the requirements of International Conference on Harmonization—Good Clinical Practice. The study protocol has been approved by the Medical Ethics Committee Utrecht (METC Utrecht) and the institutional Radiation Protection Committee of the University Medical Center Utrecht (NL75713.041.21, METC 21–053 and METC 21/633 for the biobank) as well as the Central Ethics Committee of I.R.C.C.S., Lazio (1696/22). Written informed consent is obtained from all participants.