DISCUSSION
inflammation
INFLAMMATION
This study evaluated the safety of Barbatimão gynecological ointment, comparing one group with and one without silver nanoparticles in a healthy cervix. To release an herbal medicine for use and sale, it needs some phases such as phase I, performed with groups of 20 to 100 healthy individualsThe main results obtained in this study were the absence of adverse health-damaging effects and decreased inflammation in the cervix. We observed that before its use the inflammation rate was 51.2%, while after its use, there were no cases, promoting an anti-inflammatory action. When the groups were analyzed independently, there were no statistically significant differences between the groups with or without silver nanoparticles before or after using it. The tannins present in the Barbatimão act in the healing process and reduction of inflammation through the protective layer formed by the tannin-protein complex on the injured skin or mucosaThe healing, antibacterial, anti-inflammatory, antifungal, antiparasitic and antiviral activities of Barbatimão have been reported through in vitro, in vivo, and popular use studiesThrough the vaginal secretion culture, we could determine the presence of microorganisms, pathogenic or not, of the vaginal microbiota. The majority were found in In microbiological tests the broad antimicrobial spectrum of the hydroethanolic extracts of Barbatimão was confirmed, and they observed the activity of all extracts against The toxic effect of Barbatimão was tested in a study in rats, where it was demonstrated that the concentrations deemed toxic were 800 mg/kg and 1600 mg/kg during 30 days of use