Outcomes
ADVERSE EVENTS
The primary outcome was cytokine CHA. Plasma cytokine clearance was calculated according to the following formula [Secondary endpoints included blood cytokine levels upon admission to the ICU and on days 2–4 and 5–7 after ICU admission, ICU mortality, 28-day all-cause mortality, VAI [Safety and feasibility outcomes included the number of patients with serious adverse events and reactions in both arms.