Ethical approval
The study was conducted after obtaining ethical approval from the Research Ethics Committee of the Faculty of Dentistry, Alexandria University, Egypt (IRB NO:00010556-IORG 0008839). This study was registered in the U.S National Institutes of Health Clinical Trials Registry (NCT05099081). It was also performed in accordance with the principles of the modified Helsinki code for human clinical studies, as revised in 2013, and the CONSORT guidelines for reporting randomised clinical trials. Written informed consent was obtained from each participant.