Numerical example: evaluation of the mutagenicity
We adopt the mutagenicity data set in Hauschke et al. [Summary statistics for the number of micronuclei per animal and 2000 scored cells for the vehicle control, four doses of hydroquinone and the positive control of 25 mg/kg cyclophosphamideThrough comparing the difference between a dose group and a vehicle control with the difference between the positive control and the vehicle control, the non-inferiority test can also be adopted to verify the safety in toxicological experiments. Therefore, the above mutagenicity data can be evaluated by such non-inferiority test. Hothorn and Hauschke [Upper 95% confidence limits for From Table 