Data collection
Demographic characteristics (e.g., age, sex, and marital status) were recorded during the first visit. Blinded investigators collected data on neuropsychological and neuroimaging parameters at Fujian Provincial Hospital before and within 2 weeks after the intervention. In addition, the data collection staff received training to standardize neuropsychological measurements and MRI data. To improve test efficiency and reduce unnecessary time delay, we arranged the questionnaire in the following order on the condition that the scale was correctly tested: 1) Complete the overall cognitive assessment first: MoCA, MMSE; 2) Complete the AVLT immediate-term because the AVLT long-term requires a 20-min interval [Before MRI scanning, the participants were provided individual psychological counseling by the imaging physician and were informed of scanning precautions: no magnetic substances in the body, no clothes except underwear, change into provided examination clothes, and removal of all metal ornaments and removable teeth. The participants were told to lie quietly on the scanning bed with their heads still and eyes closed. However, they were instructed to stay awake and not engage in conscious thinking during the scanning. In addition, to reduce the effect of head movement, the participants were required to wear a noise-resistant earpiece dedicated to magnetic resonance to reduce noise effects. The noise-resistant earpiece filled the space between the head and the coil. During data post-processing, head motion correction was based on a rigid body motion model. It was carried out to eliminate subject data with translational motion higher than 3 mm and rotation greater than 3°. The research team conducted water film and coil performance tests before each formal data collection to ensure that all system indicators complied with fMRI BOLD signal acquisition standards and reduced system noise.