Introduction
intracranial hemorrhage, cerebral hypoxia
INTRACRANIAL HEMORRHAGE, EXTREMELY LOW BIRTH WEIGHT, ANEMIA OF PREMATURITY, SECONDARY, CEREBRAL HYPOXIA
Anemia of prematurity is frequent in infants with extremely low birth weight. These infants are among those who most frequently undergo transfusions in neonatal intensive care unitsFollowing RBC transfusions, preterm infants exhibit minimal change in peripheral oxygen saturation (SpOTissue oxygen saturation and response to transfusion may also have long-term implications. A higher burden of cerebral hypoxia has been associated with severe intracranial hemorrhage and abnormal electroencephalography findings.In a secondary prospective observational study (TOP NIRS) of a subset of infants enrolled in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network TOP trial,