Data availability
Data supporting the current study are part of a registered clinical trial (NCT01515462). All the data generated in this study have been deposited in the San Raffaele Open Research Data Repository 10.17632/25v78pp9pg.1. These data are available under restricted access for the sensitive nature of the clinical data, access can be obtained by request to the corresponding author (Prof. Alessandro Aiuti, San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute, Milan, 20132 Italy.). We intend to reply to any requests within two weeks and we will share the deposited data only for research purposes. The non-clinical data generated in this study are also provided in the Source Data file. Additional requests should be directed to the corresponding author. 