Authors’ contributions
SK was responsible for the research idea, study concept, and design, and had the primary responsibility of studying and writing the paper. YT and NN composed the study protocol and constructed the study management team. YK constructed the statistical analysis plan. MA compiled the datamanagement system. NT and HK participated in composing the study protocol and enrolling patients. SM was also responsible for the research idea, the study concept, and designing and organizing the study as a principal investigator as well as supervising the writing of the paper. All authors read and approved the final manuscript.