Statistical analysis
REGRESSION
Participant demographic characteristics were summarised using frequency distributions for categorical variables and means with SDs for continuous variables. The analysis used in this study is part of the pre-planned objectives outlined in the trial protocol and the methods used follow those listed in a prespecified statistical analysis plan. Simple logistic regression analyses were used to compare the nasopharyngeal colonisation prevalence of pneumococcal serotype categories (overall PCV10 vaccine serotypes included serogroups and serotypes 1, 4, 5, 6B, 7A or 7F, 9A or 9V, 14, 18B or 18C, 19F, and 23F, and PCV13 vaccine serotypes included all PCV10 vaccine serotypes and serotypes 3, 6A, and 19A. Serotypes not included in either PCV10 or PCV13 were classified as non-vaccine serotypes for each respective vaccine. New acquisition of a pneumococcal serotype was defined as nasopharyngeal colonisation by a serotype not identified at 9 months of age and identified at 15 months or 18 months of age. The pneumococcal acquisition rates were expressed per 100 children aged 15 months or per 100 children aged 18 months.The putative protective correlates against PCV10 vaccine-serotype colonisation proposed by Voysey and colleaguesThe trial was registered with 