Ethics
The BRIDGES 2 trial was approved by the ethics committee of the University of Göttingen and the ethics committee of Syiah Kuala University in Banda Aceh (reference 113000211117). The trial has been registered with ISRCTN registry at All potential participants were informed that their participation in the study was voluntary, and that even after enrolment they could elect to withdraw from the study at any time. Those who agreed to participate had to sign the informed consent form.All methods were carried out in accordance with relevant guidelines and regulations.