Tralesinidase alfa 300 mg normalizes HS and HS-NRE.
Total HS and HS-NRE concentrations in CSF were measured weekly over the course of Study 250-201 Part 1 (During the course of Study 250-201 Part 2, HS-NRE levels in the CSF were normalized after the first 4 weeks of treatment to levels below the 10 ng/mL higher-end-of-normal cutoff (We observed significant correlations between total HS and HS-NRE levels in both CSF and plasma at different time points (