Introduction
pneumonia, sleep disorders, fatigue, anxiety, inflammation, viral infection, microvascular thrombosis, infection, psychiatric, depression, obsessive–compulsive disorder
NEURODEGENERATION, PNEUMONIA, INFLAMMATION, DISEASE, VIRAL INFECTION, DISORDERS, INFECTION, CORONAVIRUS, PATHOLOGY, SEVERE ACUTE RESPIRATORY SYNDROME
In the last days of 2019, several cases of pneumonia of unknown etiology were reported to the World Health Organization (WHO) in Wuhan, China, which cause was confirmed to be of the Coronaviridae family a week later and is now called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [In a systematic review of PCS symptoms, Nasserie et al. reported that 72.5% [55–80%] of COVID-19 patients had at least 1 persistent symptom after the initial disease. The most common symptoms were fatigue (median frequency of 40%) and sleep disorders (29.4%) [Several mechanisms have been suggested for PCS. Nalbandian et al. mentioned overlapping categories of severe systemic inflammation, microvascular thrombosis, neurodegeneration, and direct viral infection as possible underlying pathology of neuropsychiatric post-COVID symptoms. They proposed that chronic low-level inflammation in the brain and accumulation of memory T cells can lead to persistent effects of COVID-19 [Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI) that is mostly used to treat depression, anxiety disorders, and obsessive–compulsive disorder [As mentioned above fluvoxamine has a probable influence on major pathways contributing to PCS neuropsychiatric symptoms, especially when taken in active disease, thus acting as a prophylactic agent for COVID-19 and PCS. Besides, its main effect as an SSRI can also lead to reduced stressors during infection, contributing to a lower chance of psychiatric problems after recovery [