Author contributions
L.F.L.C. and A.G.V. designed the study and obtained funding. L.F.L.C., M.D.M., L.E.L.C., N.E., C.R.C., C.S. and M.H. recruited and followed-up study volunteers. A.S.A., M.T.R., A.S.G. and M.C.L. collected, processed and analysed clinical samples. A.S.A., E.M.M. and M.D.M. collected and managed the database. L.F.L.C., J.M.P.F. and A.S.A. performed data analyses. A.S.A., A.G.V and L.F.L.C. drafted the original manuscript. All authors participated in reviewing and editing the manuscript.