Treatment
toxicity, Toxicity, Cancer
DISEASE PROGRESSION, DISEASE, CANCER
Before the first chemotherapy, several tests including physical examination, full blood count, clotting screen, urea and electrolytes, creatinine clearance, liver function tests, ECG, and chest CT scan were carried out for evaluating the disease. At the beginning of each treatment cycle, a complete blood count, liver function tests, and a chemistry panel were retested. Radiographic studies were repeated after every 2 cycles of treatment.Irinotecan (Jiangsu Hengrui MedicineCo. Ltd.) was administered at 100 mg/mPatients were given a minimum of one therapy cycle until evident disease progression or severe toxicity occurred. The grading of all toxicity was in alignment with the National Cancer Institute Common Toxicity Criteria (CTCAE) 4.0. Dose adjustments were based on maximum toxicity observed from the prior cycle as previously described.