Baseline serum levels and correlation with baseline disease activity
PsA, tumor necrosis, Psoriasis, psoriasis, PsO
TUMOR NECROSIS, PSORIASIS, PSORIASIS, PSORIATIC ARTHRITIS, ADHESION, PSORIATIC ARTHRITIS, DISEASE
Baseline serum concentrations of IL-6, IL-10, IL-17A, IL-17F, IL-22, TNFα, and IFNγ were significantly higher in the COSMOS biomarker cohort compared with healthy controls (Fig. Baseline levels of serum cytokines (IL-10, TNFα, and IFNγ), Th17 effector cytokines (IL-17A, IL-17F, and IL-22) and acute phase proteins (CRP, SAA, and IL-6) in participants with TNFi-IR PsA from COSMOS and in healthy controls. 
Correlation of baseline cytokine biomarker levels with baseline clinical activity measures in participants with TNFi-IR PsA in the COSMOS biomarker cohortStatistics based on Spearman linear regressionBolded text highlights significant correlation between biomarker and clinical activity (BSA, body surface area; CRP, C-reactive protein; DAPSA, Disease Activity index for Psoriatic Arthritis; DAS28-CRP, 28- Disease Activity Score with C-reactive protein; IL, interleukin; PASDAS, Psoriatic Arthritis Disease Activity Score; PASI, Psoriasis Area and Severity Index; PsA, psoriatic arthritis; PsO, psoriasis; SAA, serum amyloid A; sICAM, soluble intercellular adhesion molecule-1; SJC, swollen joint count; sVCAM, soluble vascular cell adhesion molecule; TJC, tender joint count; TNF, tumor necrosis factor; TNFi-IR, tumor necrosis factor inhibitor-inadequate response