Introduction
dyscognition, traumatic brain injury, pain, TBI, FMS
VEHICLE ACCIDENT, FMS
Fibromyalgia Syndrome (FMS) is a common, chronic condition clinically characterized by widespread pain, dyscognition and associated symptoms [Current treatment for FMS relies on multidisciplinary interventions, with only a modest role for pharmacological agents [While the etiology of FMS remains incompletely understood, the interaction between genetic predisposition and exposure to various types of triggers is considered to underlie many cases. Among these triggers, traumatic brain injury (TBI), resulting from an external mechanical force, such as an impact during a fall, a rapid acceleration or deceleration during a motor vehicle accident or a blast wave, has frequently been described as an inciting factor [Hyperbaric oxygen therapy (HBOT) is a medical treatment in which 100% oxygen is administered at an environmental pressure greater than one atmosphere absolute (ATA) [In the current study, we have attempted to evaluate the therapeutic effect of HBOT on FMS patients with a clear clinical history of TBI and to compare it to the current standard pharmacological treatment. Our objective was to ascertain the clinical utility of this treatment in this specific subgroup of FMS patients, as well as studying the neuroplasticity effects of the intervention through metabolic brain imaging.