Study design and participants
low back pain, lower limb arthroplasty, malignancy, KOA, infectious disease, Musculoskeletal knee deformity, sciatica
NEUROLOGICAL DISORDER, RECRUITMENT, INFECTIOUS DISEASE
This study was a single-blinded, two-arm, parallel-design, randomized control trial. It was conducted at Sindh Institute of Physical Medicine & Rehabilitation, Karachi, Pakistan, duration of April 2021 and September 2021. This study included participants 40 years and above, subjects with tight hamstring muscles, and American College of Rheumatology clinical and radiological classification criteria for KOA. However, the participants with positive SLR (sciatic nerve test), a neurological disorder that impacts the lower extremity, Musculoskeletal knee deformity e.g., varus, lower limb internal fixation, previous history of lower limb arthroplasty or any type of knee surgery, Previous history of malignancy or any infectious disease which effecting the lower extremity, any assistive device(stick/cane), Previous history of spinal surgery, and subjects having sciatica or low back pain were excluded from the study. The CONSORT flowchart is presented in Fig. 
CONSORT flowchart of the recruitment, randomization and follow up of participant