Exclusion criteria
Cardiomegaly, diarrhea, impaired kidney, liver, h)Hypoxemia, anuria, HUS, ventricular hypertrophy
ELEVATED BLOOD PRESSURE, EFFUSIONS, ANURIA, CHRONIC DISEASE, VENTRICULAR HYPERTROPHY

Presence of advanced HUS, defined by:Hematocrit < 30% ANDPlatelet count < 150 × 10Creatinine > 2.0 mg/dL (177 µmol/L)The presence of only 1 or 2 of these criteria will not result in patient exclusion, regardless of how close the 3rd criterion is to meeting the exclusion criteria.Prior episode of HUS or diagnosis of atypical HUS [Chronic disease limiting fluid volumes administered (e.g., impaired kidney, liver, or cardiac function, chronic lung disease)Evidence of anuria (i.e., no urine output for > 24 h)Hypoxemia requiring oxygen therapyHypertensive emergency defined as:Elevated blood pressure above the 99th percentile for age [ANDEvidence of neurological change (any of the following)SeizureDiplopia or blurred visionSevere vomitingHemiplegiaORSevere chest pain with any of the below:Cardiomegaly on chest X-RAYLeft ventricular hypertrophy on electrocardiogram or echocardiogramPleural effusions on X-ray
Greater than or equal to 10 days since onset of diarrhea or if no diarrhea then the onset of other symptoms [Known pregnancyLanguage barriers impairing appropriate conduct of the study protocol and/or inability to obtain informed consent