2.1. Study Subjects
diabetes mellitus, CKD
DIABETES MELLITUS, CARDIOVASCULAR DISORDERS
In our earlier paper [Exclusion criteria included the existence of cardiovascular disorders, diabetes mellitus, arterial hypertension, or any other illnesses that required pharmacological treatment. These ailments could impact athletes’ ability to perform in sports or put them at risk for subsequent injuries. Additionally, participants were required to stop using any performance-enhancing supplements (such as creatine, β-hydroxy-β-methyl butyrate, caffeine, protein powder, weight gainer, thermogenic, etc.) at least one week before baseline testing and to refrain from doing so for the duration of this study.This study was authorized by the Human Ethics Review Board, First Faculty of Medicine and General University Hospital, Prague, Czech Republic (ethical approval code 764/18 S-IV) and performed in agreement with the principles of the WMA Declaration of Helsinki—Ethical Principles for Medical Research Involving Human Subjects [For eight weeks, participants were randomized by an electronic randomization system to follow either CKD or RD (both requiring a 500 kcal/day reduction in total calorie intake) while engaging in three resistance exercise sessions and three cardio exercises per week (30 min run, heart rate around 130–140 beats/min). From a balanced hypocaloric diet with a reduction of energy intake of 500 to 1000 kcal from the regular caloric intake, a total caloric intake reduction of 500 kcal/day was calculated. Such diets are suggested by the U.S. Food and Drug Administration (FDA) as the “standard therapy” for clinical trials [