Efficacy endpoints
inferior corneal fluorescein
DRY EYE
The coprimary endpoints were the degree of inferior corneal fluorescein staining and ocular discomfort after 12 weeks (day 85) versus that shown at baseline (day 0), pre- to post-CAE change.Corneal fluorescein staining was measured by the Ora CalibraSecondary efficacy measures were changes in additional signs and symptoms of dry eye at all visits (Secondary Endpoints Assessed in the StudyBy region (central, superior, inferior, temporal, nasal, corneal sum, conjunctival sum, and total staining). Corneal sum was the sum of the central, superior, and inferior regions (range 0–12). Conjunctival sum was the sum of the temporal and nasal regions (range 0–6). Total eye score was the sum of all 5 regions (range 0–20). Analyses were for the study eye only.Assessed at baseline only.