General adiposity poorly reflects the risk of CV outcomes
obesity, overweight, overweight or obesity
OBESITY, MODERATE OBESITY
While used routinely in clinical practice, increasing BMI is not a reliable universal risk factor for CV-related outcomes in patients with overweight or obesity. Data from the ORIGIN trial showed that obesity, categorized using BMI, had a U-shaped association with mortality and CV outcomes, and patients with overweight and moderate obesity (BMI 25–35 kg/m