Author contributions
MH, MM
WB, MS, DD, LGH, GJ and HRS designed study protocol. SK, KD, FT, RFS and HRS served as a site principal investigator. SK, JSH, DD, KD, FT, MH, RFS, JSW and HRS contributed patients, collected and reviewed patient data and data queries. MM performed accompanying experimental investigations. KD and SKS performed central MRD diagnostic by qPCR. MH and FT performed central MRD diagnostic by NGS. JL, DE, RFS and JSH performed data analysis and interpretation. SKS, MH, MS, LGH, SK participated in data analysis and interpretation and edited the manuscript. JSH and HRS drafted the manuscript. All authors read, revised and accepted the submitted manuscript.