Study measurements
All ASPREE participants completed two baseline visits to finalize their eligibility for the study, and after randomization were assessed annually by trained study staff. At baseline and every annual study visit, participants underwent comprehensive evaluations of physical measures, collection of anthropometric and laboratory measurements, medical morbidities, lifestyle and socio-demographic factors, concomitant prescription medications, and other related health parameters. Full details on the ascertainment of these study measurements have been described in detail previously