5. Conclusions
stroke
CVD, EVENTS, STROKE
Our win ratio analyses incorporating priority of individual components of a composite outcome showed that the marine n−3 fatty acid supplementation had suggestive but statistically nonsignificant beneficial effects for the primary hierarchical composite major CVD outcome in all participants; however, significant beneficial effects were found among the participants with lower dietary fish intake. These benefits principally came from preventing CHD events rather than stroke events. Thus, n−3 fatty acid supplementation appears to prevent fatal and non-fatal CHD events rather than stroke, especially in people whose usual dietary fish intake is relatively low. These results justify a future RCT to assess whether n–3 fatty acid supplementation decreases the risk of CVD events, focusing on people who eat little or no fish.