Introduction
Sepsis, septic shock
SECONDARY, SEPSIS, SEPTIC SHOCK
Sepsis is common in the intensive care unit (ICU) [NaAscorbate has recently been studied in pre-clinical experiments in a sheep model of septic shock [Accordingly, we conducted a pilot, single-dose, double-blind, randomized controlled trial to evaluate the physiological effect of a single mega-dose of NaAscorbate compared to placebo in patients with septic shock. We aimed to test the primary hypothesis that mega-dose NaAscorbate would significantly increase the total UO in the first 24 h compared with placebo. We also aimed to test the secondary hypotheses that NaAscorbate would increase the cumulative UO over time and decrease the vasopressor dose requirements needed to achieve target blood pressure and would also lower the sequential organ failure assessment (SOFA) score.