Methods
SEVERE PRE-ECLAMPSIA
This prospective randomized controlled trial was approved by the Ethics Committee of Fujian Maternity and Child Health Hospital(NO.2021KLRD09042) and registered the study at Chinese Clinical Trial Registry on 13/12/ 2021 (Registration number: ChiCTR2100054293). Informed consent was obtained from all patients before enrollment. This manuscript adheres to the applicable CONSORT guidelines. The authors assert that all procedures contributing to this work comply with the ethical standards of the relevant national and institutional committees on human experimentation and with the Helsinki Declaration of 1975, as revised in 2008. During Jan 2022 and Jun 2022, we recruited 120 patients with severe pre-eclampsia who scheduled for elective cesarean section and planned spinal anaesthesia. The eligibility criteria include following: singleton pregnancy; severe pre-eclampsia with blood pressure at 160 − 120/100 − 80 mm Hg; heart rate 60–120 beats/min; gestational age at 35–39 week. We excluded women with BMI > 40 kg/m