PCOS and current therapeutic options
obesity, metabolic disorder, PCOS, hirsutism, weight loss
OBESITY, METABOLIC DISORDER, INSULIN RESISTANCE, HIRSUTISM, POLYCYSTIC OVARY SYNDROME 1
Polycystic Ovary Syndrome (PCOS) is a hormonal and metabolic disorder affecting up to 20% of women worldwide, depending on the diagnostic criteria used [As the exact pathomechanisms of PCOS have not yet been established, therapeutic options mainly focus on specific symptoms. For obesity, insulin resistance and other metabolic symptoms, lifestyle changes, weight loss and off-label use of metformin are most commonly recommended and prescribed. Combined oral contraceptives (COCs) are most frequently used to alleviate hormonal symptoms (oligo-/amenorrhea, hirsutism) [