Background and rationale {6a}
Less invasive surfactant administration (LISA) describes intratracheal surfactant administration via a small diameter tube to spontaneously breathing infants [Observational data from the GNN indicate that in infants with gestational age 25–28 weeks and FiOProphylactic surfactant therapy via an endotracheal tube is not superior to early CPAP and selective surfactant treatment of infants requiring intubation [