Stool viral shedding
VIRUS, VIRAL SHEDDING
Viral stool shedding peaked four days after bOPV challenge in all study groups regardless of virus type. For both types 1 and 3 the proportions of both IPV-treated groups who were shedding were similar through 28 days after bOPV challenge (Shedding of poliovirus types 1 and 3 over the 28 days after challenge with bOPV in the three study groups. Shown as percentages of each group shedding with 95% CI bars.At the predefined time-point of Day 36, 7 days after challenge, the relative risk (RR) for type-specific viral shedding (IPV + dmLT/IPV) was 1.17 (CI: 0.56–2.46) for type 1 and 0.97 (CI: 0.56–2.46) for type 3. Percentage reductions were −0.17 (CI: −1.464–0.440) and 0.03 (CI: −0.510–0.394) for poliovirus type 1 and 3, respectively. Confidence intervals for the RR contained 1.0 for treatment with IPV + dmLT compared with IPV alone and estimated risk reduction in shedding of any virus type was modest (<20%), suggesting no significant difference in viral shedding for either poliovirus type with the addition of dmLT.