Metabolic profile changes after surgery
±, weight loss
INFLAMMATION
Twelve months after mRYGB, a dramatic reduction was observed in weight with 34.2 ± 6.1% of total weight loss (TWL) at the expense of a fat mass of 36.1 ± 5.1%. As expected, a significant metabolic improvement after surgery was found with a decrease in fasting plasma glucose, HOMA-IR, HbA1c levels, and lipid profile (Following MTT, AUC for glucose significantly decreased after the intervention (pre 1677 vs post 1049 mmol/L, Insulin, glucose, and C-peptide response to MTT at baseline and 1 year post-surgery. These figures show mean and standard deviation of insulin, glucose and C-peptid (expressed in mmol/L) at each time point after meal tolerance test (MTT). Baseline represented in blue and follow-up in red.As markers of systemic inflammation, IL-6 showed a trend to decrease after surgery, but without reaching statistical significance, and fasting plasma succinate was significantly reduced after surgery at 79.74 ± 28.8 vs. 50.97 ± 15.3 µmol/L, 