INTRODUCTION
depressive disorder, psychiatric, chronic suicidality, MDD, suicidality
DISORDERS
Major depressive disorder (MDD) is one of the most prevalent and disabling psychiatric disorders globally, affecting 1 in 6 adults in their lifetime (The spatio-temporal profile of neural circuit dynamics, and information processing within the brain, is predominantly defined by the dynamic balance of excitatory and inhibitory transmission of neurons (Ketamine, an NMDA receptor noncompetitive antagonist, has shown considerable therapeutic potential in alleviating MDD and suicidality at subanesthetic, low doses (0.5–3.0mg/kg; One of the most common techniques to acquire information from EEG data is to transform the signals from time domain to frequency domain and describe the signals using well-known frequency bands: delta, theta, alpha, beta, and gamma (This present study aimed to identify changes in the spectral properties of EEG in patients with chronic suicidality (and diagnosed with MDD) after a 6-week low-dose oral ketamine treatment and determine if there was an association between EEG spectral output and clinical symptoms. Considering previous findings (