Statistical analysis
Statistical analyses were performed using the SAS software (version 9.4; SAS Institute, Inc., Cary, NC, USA). Descriptive statistics were applied to the demographic parameters and safety data. Formal comparisons between the dose cohorts were not performed in this study. Forsythin and metabolite plasma concentrations, along with PK parameters, were summarized and compared among the different dose cohorts using descriptive statistics. To examine dose proportionality for In the food effect study, This study was registered at 