4.1. Participants and Ethical Approval
hypertensive
For this study, we selected 62 hypertensive participants (27 women and 35 men) aged between 40 and 70 years. The research was carried out in accordance with the Helsinki Declaration. Before being included in the trial, all participants provided written informed permission, and the trial was approved by the Ethics Committee of the Faculty of Medicine at the University of Split on 15 December 2021 (Class: 003-08/21-03/0003; Registration number: 2181-198-03-04-21-0091). The HYPER-H21-4 trial is registered on ClinicalTrials.gov as NCT05346562. The study’s inclusion and exclusion criteria were described in our prior article [