Introduction
HEAT, COLD, BROWN
Brown adipose tissue (BAT) is comprised of specialised cells that can generate heat in response to cold exposure or adrenergic stimuli.Glucocorticoid (GC) dependent signalling plays a complex role in the differentiation of adipose tissues. The glucocorticoid receptor (GR) interacts with adipogenic transcription factors such as C/EBPβ or PPARγ2Here, we demonstrate that one week of high-dose GC treatment in healthy male volunteers does not change BAT activity despite increases in resting energy expenditure (REE). In line with these physiological measurements, we found no relevant changes in the transcriptome of human BAT. However, we could observe a higher expression of genes implicated in oxidative phosphorylation, calcium cycling and beta-oxidation in skeletal muscle.