Statistical analysis
REGRESSION
All statistical comparisons were made under a modified intention-to-treat principle. Continuous variables are expressed as means (± 1 SD) or medians (interquartile range [IQR]), and discrete variables are presented as percentages. At baseline, the means, medians, and frequencies among treatment groups were compared using the t-test, Wilcoxon test, and chi-square test, respectively. Different correlations between logarithm of CA125 (logCA125) and the logarithm of NT-proBNP (logNT-proBNP), and log-transformed exposures and peakVO2 were assessed by the Pearson test.A linear mixed regression model (LMRM) was used to analyze changes in peakVOWe used the “rwrmed” package to perform mediation analysis using regression with residualsAll analyses were performed with STATA 16.1 [Stata Statistical Software, Release 16 (2019); StataCorp LP, College Station, TX, USA].