Assessments of enrolled patients
throat, hypopigmented lesions, rash
STREPTOCOCCAL INFECTION, THROAT INFECTION
Detailed skin examination was carried out by blinded investigators (DA and MFE). Anatomical sites affected were documented. The extent of erythematous papular lesions, hypopigmented lesions and the rash as a whole was calculated at day 0, week 2, week 4, week 6 and at EOS using the rule of hand surface area (1% of body surface area). During the biweekly follow-up, any side effects were monitored and managed accordingly.Streptococcal infection was evaluated at day 0 by measuring anti-streptolysin O titre (ASOT) and anti-deoxyribonuclease B titre (anti-DNase B) and performing throat swab for culture and sensitivity. Streptococcal throat infection was defined by either positive ASOT, anti-DNase B titre, or positive throat culture for group A β-hemolytic streptococci [