4.2. Inclusion Criteria
ICHD-3, CM
HEADACHE DISORDER
Men or women between 18 and 50 years of age with CM, satisfying the diagnostic criteria of the International Classification of Headache disorders (ICHD-3) [Failure of at least two treatments with intramuscular injections of BoNT-A in the cranial/pericranial muscles performed more than 6 months ago;For women of child-bearing potential, the use of highly effective contraception.Overuse of drugs was defined as taking simple analgesics for ≥ 15 days, or other types of drugs or combinations of types for ≥ 10 days.