Background
CFS, gastrointestinal tract
DISORDERS, CHRONIC FATIGUE SYNDROME, CLOSTRIDIOIDES DIFFICILE INFECTION
Chronic fatigue syndrome (CFS) is a complex and disabling illness of unknown etiology and a heterogenous constellation of symptoms [The human microbiota is an extensive community comprising collectively over 10,000 different microbial species including bacteria, viruses and archaea inhabiting various anatomical regions, especially gastrointestinal tract [There is increasing agreement that the disruption of the gut microbiota impacts brain development, neurological outcomes, and disorders, resulting in long-term behavioral changes [Faecal microbiota transplantation (FMT) is an emerging treatment method to renew dysbiotic gut microbiota. It has well established efficacy and acknowledged position in the treatment of recurrent Clostridioides difficile infection (rCDI) [CSF patients tend to have severely impaired HRQOL and they often remain without sufficient treatment options. Thus, we aimed to investigate the efficacy of reshaping the gut microbiota in CSF patients via FMT to improve HRQOL.