Clinical outcomes
Assche, fistula, Crohn’s Disease Activity
INFLAMMATORY BOWEL DISEASE, REMISSION
Sixty percent (6/10) of patients achieved combined remission at 24 weeks. Ninety percent (9/10) and seventy percent (7/10) of patients had a clinical response at 12 weeks and 24 weeks, respectively (Table Efficacy resultsPatient representative of combined remission (male, 34 years old). (There were 17 external fistulas in 10 patients, and 13 were closed and epithelialized at 12 weeks. The external fistula recurred in two patients at 24 weeks (Table Overall, a significant reduction of the PDAI score was observed after MSCs administration. Van Assche scores demonstrated a significant reduction from the 12th week. Although CDAI scores were all less than 220, the reduction was also significant. In addition, IBDQ increased during follow-up (Fig. Treatment outcomes at different time points. PDAI: Perianal Crohn’s Disease Activity Index, IBDQ: Inflammatory Bowel Disease Questionnaire. Van Assche score (Pelvic MRI-Based Score). A two-sided P value of less than 0.05 indicated statistical significance: Wilcoxon signed rank test adjusted for multiplicityDuring the study, no patient received steroids for a flare of CD. No patient received antibiotics or anti-TNF treatment as a rescue treatment for fistula.