The Guinea Pig model of heart failure (HF)/(sudden cardiac death) SCD shows a remodeled and hyperactive ryanodine receptor 2 (RyR2).
(In our previous report, we noted HF-associated changes in both expression and phospho-proteome of key ion channels, transporters, and excitation contraction-coupling proteins. In particular, hyperphosphorylation of several RyR2 sites was noted in failing hearts when compared to normal (