Patients
irritable bowel syndrome
IRRITABLE BOWEL SYNDROME
Of 452 IBS‐D patients assessed for eligibility, 224 patients were randomized to four groups as follows: control (Flow diagram of 2 × 2 factorial design and randomized trial with two restricted diets.We recruited another 340 IBS‐D patients. After determination of eligibility, 202 patients were randomized to IgG positive food dietary restriction combined with probiotic or placebo: IgG res diet + placebo (Flow diagram of IgG positive restricted diet combined with placebo or probiotics.There were no significant differences among the first four groups or between the latter two groups with regard to; demographic data, anthropometric measurements, clinical characteristics, IBS‐D‐SSS at baseline, and TIgG titer at baseline. (Table Patient characteristics at baseline.
Abbreviations: ANOVA, analysis of variance; BMI, body mass index; IBS‐D‐SSS, diarrhea‐predominant irritable bowel syndrome Symptom Severity Scale; IgG diet, the restricted diet based on food IgG antibodies; TIgG titer, total positive IgG antibody titers. CSF diet, cold/spicy/fried restricted diet.one‐way ANOVA test.independent Chi square test.Kruskal−Wallis test.Mann–Whitney 