Composition of the coordinating centre and trial steering committee {5d}
The Trial Steering Committee monitors the overall conduct of the trial and, through its independent Chair, provides strategic advice to the Trial Management Group. The Trial Steering Committee includes several senior clinical and academic members who are independent from the trial investigators, two lay representatives, and representatives of various stakeholders in STRIDES and meets approximately two to three times per year. Furthermore, the Trial Management Group (which includes the investigators, trial coordinators, members of the PPIE panel, and operational staff from NHSBT) is responsible for overseeing the day-to-day management of the study, liaising with NHSBT, and agreeing protocol amendments prior to submission to the research ethics committee. This Management Group meets monthly throughout the study period.