Funding
C.H.
Dz.H. and Lc.W. conceived and designed this study. Ll.Z., Lc.W., Jl.C., Zt.M., Zj.L., Xl.J., Xy.W., C.H., P.C., Y.L., Rc.J., J.W., DS.Z., Yh.S., Y.Z and Cy.Z, enrolled patients and collected the data. Lc.W. and Jy.W. was responsible for statistical analysis, and all authors participated in data interpretation. Manuscript was drafted by Dz.H., Lc.W. and Jy.W. and was reviewed and/or revised by all authors. All authors reviewed the manuscript. The final version was approved to be submitted by all authors.This work was supported and financed by the National Nature Science Foundation of China (Grant No. 82172635, No. 82203628, No.82272686, and No. 82172620).