Outcomes
respiratory insufficiency
DISEASE, RESPIRATORY INSUFFICIENCY
The primary objective was the percentage of patients progressing from mild (grade 3 or 4 in the OSCI) to severe (grade 5 or more) disease. Secondary objectives included days of hospitalization, days of admission in the intensive care unit (when required), survival at 28 days, 6 months and 12 months after study inclusion and safety profile.Based on data from our own institution, the likelihood of developing severe respiratory insufficiency was 50% for hospitalized patients (Patients were allocated in a 1:1 ratio to the control or experimental arm.Cases were stratified based on prior treatment with statins and concomitant treatment with strong CYP 3A4 inhibitors.Block randomization with a block size of 4 and 6 was used. Blocks were generated by the study statistician who was also responsible for allocating patients in a blinded manner.