Abbreviations:
obesity, non-cancer, malignancy, Breast cancer, cancer, cardiometabolic disease, breast Cancer, cardiotoxicity, metabolic abnormalities, eating and reduced sedentary
OBESITY, CVD, INFLAMMATION, BREAST CANCER, CANCER
Breast cancer is the most commonly diagnosed malignancy in women worldwide, representing 25 % of annual new cancer casesThe direct toxic effects of breast cancer treatment on the heart (cardiotoxicity) are well characterised as a contributor to elevated CVD riskExcess accumulation of fat within ectopic regions (e.g. visceral, intermuscular, or hepatic) triggers adverse metabolic effects and inflammation. In non-cancer populations, ectopic fat is more strongly linked to CVD risk than the total quantity, which is dominated by subcutaneous fatDiet and physical activity interventions play important roles in the treatment of metabolic abnormalities and body composition. Intermittent fasting is a pattern of eating involving voluntary abstinence from food alternated with periods of TRE has positive cardiometabolic health effects, including reduced body fat (whole body, visceral, liver and intermuscularAppropriate nutrition and healthy eating practices can also reduce the burden of chemotherapy symptoms and improve health across the cancer continuum. Dietary intake and physical activity are inextricably linked to cardiometabolic disease risk through reciprocal contributions to energy balance and obesity. Outside of sleep, time spent not being physically active is considered sedentary time, defined as any waking behaviour done while sitting, reclining or lying down that expend ≤ 1·5 metabolic equivalents. Sedentary time has consistently shown to be higher in cancer survivors than controlsThe purpose of the Impact of Metabolic health Patterns And breast Cancer over Time in Women (IMPACT-Women) trial is to evaluate the effect of a multimodal behavioural intervention involving TRE, healthy eating and reduced sedentary time on ectopic AT and cardiometabolic profile 