Patient Eligibility
cancer, tumor
ONCOLOGY, CANCER, TUMOR, SOLID TUMORS
Eligible patients were ≥18 years of age and provided written informed consent; had histologically confirmed advanced solid tumors, refractory to or intolerant of existing cancer therapies, with no surgical, radiation, or systemic anticancer therapies available after at least one prior systemic anticancer therapy; had accessible tumor biopsies; and agreed to use a highly effective form of contraception.Key exclusion criteria included: an Eastern Cooperative Oncology Group (ECOG) performance status ≥2; severe bone marrow (hemoglobin <9.0 g/dL, neutrophil count <1.5 × 10