Coprimary endpoint analysis
SECONDARY
The co-primary endpoint of cCR was achieved in 33 of 76 patients (43%, 95% confidence interval (CI): 32%, 55%; Fig. The median metastasis-free and overall survival for the entire study cohort was not reached at the time of the data lock (secondary endpoints). To further contextualize the prognostic impact of achieving a cCR as related to metastasis-free survival and overall survival, a post hoc landmark analysis was performed using the time of clinical restaging as ‘time 0’. On landmark analysis from the time of restaging, patients achieving a cCR experienced significantly longer metastasis-free survival and overall survival compared to patients not achieving a cCR (Fig. 