Author contributions
BRUCE
All authors contributed to the revision of the manuscript. As each author’s individual contributions, HY and TA were responsible for the research idea, conducting the clinical trials from which these data were derived, and the interpretation of the data, TakaY, KM, TakuY, and Takuya Kato were responsible for the study concept and design and managing the clinical trials and extracting the related data from the clinical trials’ database, KO and YN contributed to the concept of design and interpretation of the data, and YS and Bruce Crawford contributed to the analysis and interpretation of data and drafting of the manuscript.