Methods
PROPPR, trauma
A post hoc side-by-side analysis of the PROPPR Trial was performed between December 2021 and June 2022 to compare frequentist vs bayesian statistical techniques. Per institutional policy, this study was exempt from institutional review board approval and the requirement for informed consent due to its retrospective nature and use of publicly available, deidentified data. Manuscript preparation was guided by the Standards for Quality Improvement Reporting Excellence (The PROPPR Trial enrolled trauma patients between August 2012 and December 2013 who were expected to require large volume transfusions at 12 US level I trauma centers and randomized these patients to receive a 1:1:1 or 1:1:2 initial transfusion strategy to assess the effects of blood product ratios on mortality. Primary outcomes were 24-hour and 30-day mortality. The original study was designed to detect a 10–percentage point absolute difference in 24-hour mortality (11% vs 21%) and a 12–percentage point absolute difference in 30-day mortality (23% vs 35%) based on previously documented literature.