Conflict of interest
JR-M: Advisory boards and Consulting for BMS, Amgen, Novartis. Rainier, Janssen, Pierre-Fabre. Speaker honoraria from Roche, BMS, Novartis, MSD, Janssen, Pfizer, Astra-Zeneca. Travel, accommodations, expenses: Astellas, Novartis, Roche, BMS, Pfizer, MSD, Astra-Zeneca. Corporate-sponsored research: Astra- Zeneca, BMS, Amgen, Roche, Novartis, MSD, Janssen, Pfizer, Astellas, GSK, PharmaMar, lpsen, Tesaro, Abbvie, Aprea Therapeutics, Eisai, Bayer, Merck, IOVANCE, Nektar. JG-D: Advisory boards and Consulting for Janssen, Pierre-Fabre, BMS, Amgen, Novartis. Speaker honoraria from Pfizer, Janssen, Roche, BMS, Novartis, MSD, Astra-Zeneca. Travel, accommodations, expenses: Astellas, Novartis, Astra-Zeneca. Funding for research: Astra- Zeneca, BMS, Amgen, Roche, Novartis, MSD, Janssen, Pfizer, Astellas, GSK, PharmaMar, lpsen, Tesaro, Abbvie, Merck.The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.