Abstract
In this ongoing study, substantially increased ancestral SARS-CoV-2 neutralizing responses were observed 1 month after a third 10-µg BNT162b2 dose given to 5 to 11-year olds versus neutralizing responses post-dose 2. After dose 3, increased neutralizing responses against Omicron BA.1 and BA.4/BA.5 strains were also observed. The safety/tolerability profile was acceptable. (NCT04816643)A third BNT162b2 10-µg vaccine dose administered approximately 6 months after the second dose to 5- to 11-year olds increased neutralizing titers, including against Omicron BA.1 and BA.4/BA.5 strains. The safety and tolerability profile of the third BNT162b2 10-µg dose was acceptable.