Patients
B-cell deficiency, follicular lymphoma, CLL, mantle cell lymphoma
FOLLICULAR LYMPHOMA, CLL, MANTLE CELL LYMPHOMA, CHRONIC LEUKEMIA LYMPHOCYTIC
From July 6th, 2021 to January 13th, 2022, a total of 94 patients with congenital or acquired B-cell deficiency underwent screening at three study sites in Germany. A total of 54 patients received CoVac-1, 14 patients in the Phase I safety run-in, and 40 patients in the subsequent Phase II part of the trial. 28% of patients were female. Median patient age was 61.8 (range 37–90) years. 93% of study patients suffered from cancer-related, acquired B-cell deficiency, with chronic lymphocytic leukemia (CLL, 30%), mantle cell lymphoma (MCL, 24%) and follicular lymphoma (FL, 20%) as the most common diagnoses. Application of an approved COVID-19 vaccine prior to study inclusion was reported for 83% of patients with a median of two vaccinations per patient (Supplementary Table 