2.4. Statistical analyses
Data are expressed as mean ± SD. Sample size calculations were performed using predicted changes to measures of physical performance following statin withdrawal. Using a one-tailed model with p = 0.05, alpha = 0.8 (beta = 0.2) and aiming for a 20% mean increase in several muscle function tests using observed SD from preliminary data from 9 participants, required total n values were found to range from 15 to 30. Using FAll statistical analyses were performed using JMP software (SAS Institute, Cary, NC). In cases of missing data for any given measure, participants were removed from that analysis. Between group differences for variables not measured repeatedly over time were analyzed by ANOVA followed by Tukey post-hoc tests. A repeated measures factorial design was used to assess differences between groups and over time using the “Full factorial mixed design” add-in for JMP [