State of the art
MAY, RECRUITMENT
The PIpELINe trial is an investigator-initiated study, and the sponsor is the University Hospital of Ferrara. The sponsor received a research grant from the Italian Health Minister (Ricerca Finalizzata 2018, GR 2018-12367114). The study was approved on May 22th, 2019 by the Ethic Committee of the coordinating center (Comitato Etico Area Vasta Emilia Centro, Bologna, Italy). The study was registered on December 3rd, 2019, with the ClinicalTrials.gov Identifier NCT04183465. The enrollment phase started on March 27th, 2020. The date of the start of the recruitment was warmly recommended by the Italian Health Minister that partially supported the conduction of the study. It was concomitant to the first wave of the COVID-19 pandemic. The pandemic dramatically affected the recruitment in the 2020 and in the first 6 months of the 2021, due to reduction in the hospital admission for MI [