Acknowledgements
J-.P.W., F.K., and J.A.B.
The authors thank the participants for their time and commitment to the study. The authors also thank Isobel Townsend, Drusus Johnson-Bonson, Matthew Farrow, Robert Edinburgh, and Oliver Chrzanowski-Smith for their help on occasional trial days. The authors would also like to thank William Trim and Jariya Buniam for occasional assistance with biochemical analysis. J.T.G, A.H., P.J.R., J.M.B., L.J.C.v.L., F.K., D.T., and J.A.B. designed the research. A.H., J.T.G, R.G.D., J-.P.W., F.K., and J.A.B. conducted the research. P.J.R., and J.M.B., provided essential reagents or materials. A.H., and J.T.G analysed data, performed statistical analysis, and wrote the initial draft of the manuscript. All authors contributed to manuscript editing. J.T.G had primary responsibility for the final content.