Subgroup analyses
REGRESSION
Subgroup analyses will be limited to minimisation variables: sex and Tanner stage, for the primary outcome only. Tests for statistical heterogeneity (e.g. by including the treatment group by subgroup interaction parameter in the regression model) will be performed prior to any examination of effect estimate within subgroups. The results of subgroup analyses will be treated with caution and will be used for the purposes of hypothesis generation only.