Discussion
colorectal cancer, toxicity, tetany, laryngeal nerve injury, arrhythmias, heart failure, hypocalcemia, PTC
COLORECTAL CANCER, COMPLICATION, LARYNGOSPASM, ARRHYTHMIAS, HEART FAILURE, HYPOCALCEMIA, COMPLICATIONS
This is the first prospective multicenter randomized blank-controlled trial. The study met its primary endpoint and carbon nanoparticles were proven to be safe.The most effective treatment for PTC is complete removal of the primary and metastatic lymph nodes. However, the insensitivity of preoperative imaging may lead to an incomplete lymph node dissection. Although not usually fatal, it can lead to repeated surgeries and more damage to patients. Previous sample- or single-center studies have shown that carbon nanoparticles can effectively detect more lymph nodes in colorectal cancer (Post-thyroidectomy hypocalcemia is the most common complication that seriously affects patients’ quality of life. In a few cases, hypocalcemia can be severe and lead to acute life-threatening conditions, such as tetany, laryngospasm, arrhythmias, and heart failure (Clinically, parathyroid glands may be accidentally removed as LNs owing to variations in position. CNs have high specificity for the lymphatic system as lymph tracers. CNs have been successfully applied in gastric (Although there was a significant difference in the parathyroid hormone level between the carbon nanoparticles and control groups at postoperative one month in the TT subgroup, there was no significant difference in serum CaNo drug-related AE or complications due to the injection of carbon nanoparticles were recorded in this study. There were no significant differences between the two groups with respect to recurrent laryngeal nerve injury in the UL and TT subgroups. None of the patients experienced any discomfort during the study period. The clinical application of CNs has shown no toxicity (This study had several limitations. First, this study could not be double-blind and may be biased when clinicians perform surgery. More, this study adopted competitive enrollment, and experienced surgical centers have more participants, which may lead to selection bias. Experienced surgeons, whether using carbon nanoparticles or not, have less impact on parathyroid blood flow and are less likely to miscut.