5. Conclusions
dysplasia, colorectal adenomas
DISEASE PROGRESSION, DYSPLASIA, DISEASE CHARACTERISTIC
In conclusion, the combined treatment of curcumin and anthocyanins in patients with colorectal adenomas did not directly modulate circulating biomarkers. While the expected changes in biomarker levels were not observed, our study yielded intriguing results, shedding light on the complex interplay between metabolic and inflammatory pathways. The uncovered correlations between adiponectin, BMI, glycemia, inflammatory markers, and leptin provided valuable insights into the intricate regulatory mechanisms within the body. Additionally, the findings of an inverse relationship between adiponectin levels and dysplasia grade post treatment, along with an increase in IL-6 in subjects with high baseline dysplasia grade, warrant further investigation into the potential roles of these biomarkers in disease progression. Our research underscores the importance of understanding the multifaceted interactions between metabolic and inflammatory pathways in patients with colorectal adenomas and may guide the development of novel treatment strategies tailored to individual disease characteristics.