Study design
MeS
The current study is a prospective, parallel, randomized, double-blind, placebo-controlled clinical trial. The study was conducted on subjects with MeS referred to an endocrine and metabolism research center and an outpatient clinic affiliated to Isfahan University of Medical Sciences, Isfahan, Iran. The ethics committee of Isfahan university of medical science reviewed and approved the study protocol (ID: IR.MUI.RESEARCH.REC1399.595). The clinical trial was registered at the Iranian Registry of Clinical Trial (Code: IRCT20121216011763N49). All methods were conducted based on the approved study plan, as well as with relevant guidelines and regulations.