Ethics

This prospective, randomized study was conducted from April 2019 to September 2020 at the Huadong Hospital affiliated to Fudan University, Shanghai, China. The study was appoved on 6 March 2019 by the Ethics Commission of Huadong Hospital affiliated to Fudan University under the approval number 20,190,030. All patients were informed about the research purposes along with the practical aspects and gave written informed consent prior to inclusion. The trial was registered prior to patient enrollment at Chinese Clinical Trial Registry (