Study design and participants
MCI
RECRUITMENT
The CANN trial was a 12-mo randomized placebo-controlled parallel study with 2 intervention arms. There were 2 recruitment sites, the UEA (Norwich, UK) and SUT (Melbourne, Australia), with MRI analyzed centrally at the University of Illinois (Urbana Champaign, Urbana, IL, United States). Participants were asked to attend 3 clinical visits, at 0 mo (baseline), 3 mo, and 12 mo, to undergo cognitive assessment and provide clinical measures and biological samples. MRI assessment was conducted at baseline and 12 mo in a subset of Participants recruited were aged ≥55 y, with either SCI or MCI [