Strategies to improve adherence to interventions {11c}
The patient is contacted weekly by telephone and visits the clinic bi-weekly. Issues related to the course of the study (adherence to medication, side effects, other issues) are discussed and possibly resolved. The patient may contact the investigator at any time by e-mail or telephone to discuss additional issues related to the study.Medication is provided for no longer than for 2 weeks when they visit the coordinating center. On the third to fifth visit, medication is provided to the patients after they returned their previous stash of medication (oxycodone tablets and/or cannabis). The returned medication will be destroyed.Patients who drop-out of the study prior or after randomization or prior or after treatment initiation will be replaced by another patient such that we will have three groups of 20 patients that will successfully complete the study. As indicated above, all patients that started on treatment will be included in the intention-to-treat analyses.