Author contributions
PATHOLOGY
L.V. coordinated trial procedures, analyzed and interpreted clinical and translational data of the trial and wrote the paper with O.I.I. and M.K. O.I.I. performed and interpreted computational analyses of the DNA- and RNA-sequencing data. H.M.H. and R.S. performed the histological scoring of the pathology slides. S.B. and K.S. performed the statistical analysis of the trial data. M.C. performed computational analyses of the flow cytometry data. N.A.M.B., E.C. and H.G. were responsible for blood sample processing and analysis, supervised by K.E.d.V. and M.K., and H.G. designed the flow cytometry panel. C.E.L. revised RECIST1.1 measurements and, together with colleagues, was involved in taking biopsies. I.K. was responsible for participant care. I.A.M.M. was the clinical projects manager. M.d.M. performed DNA and RNA isolations. J.J.L.v.G. and J.B. coordinated trial procedures in one participating center including the ImaGelato case. M.d.B., M.G.J.v.D., G.S.S., V.C.G.T.-H., C.P.S., S.C.L. and M.K. were the main treating physicians. G.S.S., K.E.d.V., T.N.S., C.U.B., S.C.L. and M.K. wrote the trial protocol. L.F.A.W. supervised computational analyses. A.J., V.C.G.T.-H, C.P.S. and M.K. were the principal investigators of the trial. All authors edited and approved the paper.