Introduction
Kaposi sarcoma, Kaposi Sarcoma
KAPOSI SARCOMA, DISEASE, KAPOSI SARCOMA, EVENTS
Kaposi Sarcoma (KS) and High HHV-8 VL levels are associated with disease severity and mortality [We performed a randomized clinical trial to test the hypothesis that valganciclovir (ganciclovir prodrug, as an anti-HHV-8 agent) started four weeks before cART initiation, in patients with disseminated Kaposi sarcoma (DKS), would reduce the mortality associated to Severe-IRIS-KS and the incidence of Severe-IRIS-KS events. We also evaluated whether or not in the presence of coinfections serum cytokine levels (IL6, IL10, TNF, and IFN-ɤ,) and C-reactive Protein (CRP) correlated with Severe-IRIS-KS occurrence.