Introduction
periodontitis, CVD, tooth loss, Periodontitis, heart failure
ENDOTHELIAL DYSFUNCTION, CVD, PERIODONTITIS, PERIODONTITIS, HEART FAILURE, INFLAMMATORY DISEASE, INFLAMMATORY RESPONSE
Periodontitis is a chronic, multifactorial, inflammatory disease caused by infectious biofilm that, if not prevented and treated appropriately, might destroy the tooth-supporting tissues and cause tooth loss [Recently some cohort clinical trials have shown that the growth differentiation factor 15 (GDF-15), a biomarker released in cardiac and blood wall tissues in response to heart volume expansion or abnormal pressure load, is associated with early diagnosis and bad outcomes in patients with CVD and heart failure [In periodontitis patients, previous reports have shown that upregulated GDF-15 levels sustain the inflammatory response of periodontal ligament fibroblasts against Finding mediators that might improve the predictive accuracy of systemic inflammatory risk and assessing the impact of periodontal therapy on early indicators of CVD and endothelial dysfunction are of increasing interest. In this regard, the purpose of the present randomized clinical trial (RCT) was to evaluate the effect of NSPT performed either through Q-SRP or FMD on GDF-15, GPx-1, hs-CRP, and SP-D concentrations in patients with periodontitis at 6-month follow-up after treatment. In addition, it was analyzed the impact of both NSPT protocols on serum GDF-15, GPx-1, hs-CRP, and SP-D, and if patients who harboured high baseline GDF-15 and related biomarkers levels benefited more from the efficacy of NSPT. The null hypothesis to invalidate was that, at the 6-month follow-up, there were no significant changes in serum GDF-15, GPx-1, hs-CRP, and SP-D among enrolled patients treated with different NSPT and that baseline biomarkers did not impact the efficacy of NSPT.