Introduction
cognitive impairment, cognitive deficits, long-term disability, metabolic disorders, schizophrenia, Cognitive impairment
CORTEX, METABOLIC DISORDERS
Cognitive impairment is a core schizophrenia feature and contributes remarkably to poor functional outcomes and long-term disability [Accumulating evidence suggests that metabolic disorders may accompany and act as a critical risk factor for cognitive impairment in schizophrenia [The dorsolateral prefrontal cortex (DLPFC) is a critical brain region for cognitive functions [Here we aim to investigate if metformin administration could improve cognitive functions in patients with schizophrenia. We first conducted a randomized interventional study of 72 participants with schizophrenia to receive antipsychotics plus metformin or antipsychotics alone; we then defined relationships between metformin treatment and cognition improvement. Functional connectivity alterations of DLPFC with other brain regions were analyzed to understand the neural mechanisms related to potential changes in cognition in these subjects. The study explored whether evidence supports the use of metformin to treat cognitive deficits in patients with schizophrenia.