Taxonomic differences of oral microbiome in Low- and High-responders
gram-negative
To find the bacteria taxa that were differentially abundant between the High- and Low responders, Linear discriminant analysis Effect Size (LEfSe) analysis was applied for the HC and PLHIV data separately. Shown in Oral microbial signatures associated with long-term antibody responses in HC and PLWH. We further determined the predictive values of the identified microbial features as a validation and to address how well they could distinguish the outcome of vaccination responses in the participants. The results obtained from area under the receiver operating characteristic curves (AUROC) indicated that these microbial features individually (We considered that there could be functional resemblances beyond the identified bacteria taxa. Striking, we observed functional associations indicating that, among Low-responders of HC as well as of PLHIV, the enriched taxa were mainly of anaerobic, gram-negative (lipopolysaccharide LPS+) bacteria species with known proteolytic activities (Overview of microbial features, enriched in high- and low-responders to COVID-19 vaccine, per study group (HC and PLHIV).Oral microbial signature and KEGG metabolism associated with High 