2.9. Analysis
In this study, we used the intention to treat (ITT) principle. We calculated the change scores in each cognitive function (post–pre difference score). R (ver. 4.10) was used to conduct all analyses. A multiple imputation method with predictive mean matching was used to impute data (m = 20). All variables were included in the data imputation process. The multiple imputations were performed using the function of “mice” of the mice package in R [