Trial design and ethics
This single-center prospective, randomised, double-blinded study was approved by the Ethics Committee of the Second Affiliated Hospital of Anhui Medical University, Anhui province, China (Chairperson Prof. Yanghua Tian) on December 2, 2021 (Ref YX2021-114) in accordance to the principles of the Declaration of Helsinki. The trial was registered in clinicaltrials.gov (NCT05240482) and carried out at the Second Affiliated Hospital of Anhui Medical University from 20 February to 6 July 2022. Written informed consent was obtained from all participants. The time period of this trial consisted of a 72-h follow-up after bariatric surgery in the hospital and a follow-up period of an additional 3 months after discharge.The LSG was performed by the same bariatric surgical team, basically referring to the International Sleeve Gastrectomy Expert Panel Consensus Statement [