Introduction
depression, traumatic
The antidepressant efficacy of repetitive transcranial magnetic stimulation (rTMS) may be related to the connectivity of the stimulation targetWhile the sgACC approach has been employed most commonlyRSNM enables precise individualized mapping of the DMNOf note, much of the existing knowledge about individualized brain mapping has been based on studies of healthy individuals. It remains unclear whether this generalizes to patients with neuropsychiatric illnesses and brain injuries. Inter-individual variability may be particularly prominent in traumatic brain injury-associated depression (TBI-D), which is associated with altered FC in the DLPFC, sgACC, DAN, and DMNAs a first step to addressing these questions, we explored the differences between potential target sites generated using individualized RSNM (RSNM-based targets), standard anatomical methods (structural targets), and the point of maximal anti-correlation with the group-mean location of the sgACC (sgACC-derived targets). We also explored the connectivity changes induced by stimulation of RSNM-based targets in a recent pilot clinical trial