Regression analysis
REGRESSION, REGRESSION
Regression analyses were performed using clinical and PRO data collected in study 301 to identify significant predictors for ΔBL FACIT-F score and EORTC QLQ-C30 GH score. Patient clinical and demographic characteristics were analyzed as covariates in the regression analyses. Covariates included for the full models of both PROs were baseline and ΔBL LDH levels, baseline and ΔBL Hb levels, baseline FACIT-F and EORTC QLQ-C30 GH scores, age, sex (male/female), concomitant AA or MDS (yes/no), transfusion (yes/no), treatment group (eculizumab/ravulizumab), reticulocytes/erythrocytes ratio (baseline, defined as high [≥ 2.3%], normal [0.2–2.3%], and low [≤ 0.2%]), ΔBL platelet count, ΔBL neutrophil count, and body mass index. Generalized linear regression models were fit for each outcome and set of covariates. These were conducted using the 