Discussion
bleeding
BLEEDING, MEDICAL COMPLICATION
The development of pediatric HA-VTE is associated with longer hospital stays, increased medical costs, and subsequent medical complications,We hypothesize that the intervention’s primary lack of success in decreasing HA-VTE rates was due to low rates of thromboprophylaxis acceptance when recommended. Multiple clinical teams cited their concern that initiating pharmacologic prophylaxis would increase their patient’s risk of bleeding; however, prior literatureOther reasons that the intervention may have been unsuccessful include potentially ineffective dosing of thromboprophylaxis. During the study period, we recommended standard weight- and age-based prophylaxis dosing of unfractionated heparin and low-molecular-weight heparin for elevated risk patients deemed clinically safe for pharmacologic prophylaxis; however, recent data have emerged suggesting that HA-VTE associated with a central venous line (CVL) in patients with a history of HA-VTE may be prevented more effectively by using higher doses of pharmacologic prophylaxis.