Measurements of major outcomes
irritability, sleep disturbance, anxiety
All patients were required to keep a log of their actual medication administration daily due to possible errors while undergoing an irregular dosing schedule. Patients could contact the study team during the course whenever they felt unsure if any relapse sign might be re-emerging, such as anxiety, irritability, restlessness, oversensitive to interpersonal or perceptual cues, and sleep disturbance (Yang, Shih, Yeh, & Chen, 