4. Discussion
obesity, obese, overweight, hypertension, TG, Nitraria, dyslipidemia
OBESITY, OBESE, ABNORMAL MENSTRUATION, HYPERTENSION, COMPLICATIONS, DYSLIPIDEMIA
In the present study, we have reported the tolerability, acceptability, and safety of the short-term daily intake of NRE infusion in adults. Importantly, our results indicate that NRE might offer potential benefits for improving lipid profiles, particularly in overweight and obese individuals, highlighting the importance of conducting future controlled, randomized, large-scale clinical trials to validate and further explore these findings. Our study is the first to provide valuable insights into the potential antihyperlipidemic benefits of NRE in human volunteers.The results obtained from this study suggest that the administration of NRE did not negatively affect the hepatic and renal balance. Moreover, there were no statistically significant deviations observed in any other hematological parameters, providing further evidence for the safe daily consumption of NRE infusion. Participants exhibited high compliance, with no reported problems or complications related to the daily ingestion of 2000 mg of NRE. However, a subset of overweight and obese participants did report experiencing transient laxative and diuretic effects for a limited duration. Furthermore, the antihypertensive effect of NRE is not well explored. In fact, few studies mentioned that the fruits and leaves of Nitraria have been used as a nutritional food and traditional herb for the treatment of hypertension and abnormal menstruation [Overall, the findings of this study establish the safety and tolerability of NRE in healthy adults following a 10-day consumption period. Additionally, we investigated the impact of the continuous intake of Our findings revealed that a higher dosage of NRE resulted in a decrease in TG levels and an increase in HDL levels (The therapeutic effects of NRE can largely be attributed to the presence of various active compounds, including alkaloids, flavonoids, and coumarins. According to the previous study, the phenolic profile of Active compounds such as alkaloids, flavonoids, and coumarins have demonstrated significant cardioprotective effects [Numerous in vitro and in vivo studies have reported the impact of isorhamnetin on obesity, highlighting its ability to reduce adipogenesis, restrict body fat accumulation, and improve glycemia and serum lipid profile [In this study, the observed decrease in TG levels may be attributed to multiple mechanisms. Firstly, NRE may potentially inhibit the absorption of TG into the body while promoting its degradation and elimination through feces. Additionally, NRE may stimulate the transfer of TG to HDL. Numerous studies have highlighted the cardioprotective properties of HDL, including its ability to safeguard LDL from oxidative modification [At present, fibrates are widely prescribed as oral hypolipidemic agents in clinical practice for managing dyslipidemia [In our study, we also evaluated the levels of TC and LDL as lipid biomarkers. No statistically significant changes in these lipid parameters were observed after daily consumption of NRE in both groups of participants, compared to their baseline levels. The inconsistent results may be attributed to this study group’s relatively lower baseline TC and LDL levels. Additionally, participants were instructed to maintain their regular diet without any restrictions, which suggests that the dietary components of their lifestyle may have had a more pronounced impact on plasma cholesterol levels than the NRE intervention, potentially introducing confounding effects. Furthermore, the lack of distinct differences in lipid biomarkers could also be attributed to the relatively short duration of the treatment period.A more extensive and prolonged study, encompassing a larger number of participants from both genders within the same age range, is nevertheless warranted in order to achieve a more precise evaluation of the benefits conferred by NRE. Investigations of the benefic effects of 