Introduction
stroke, subacute stroke stage, post-stroke
STROKE, CORTEX
The randomized controlled trials (RCTs) of transcranial direct current stimulation (tDCS) applied to the primary motor cortex (M1) concurrently with rehabilitation therapy at the subacute stroke stage (> 7 days to 3 months) [Many factors may influence the tDCS effects on post-stroke motor recovery [Here, we stratified stroke patients by the paretic UE severity and CST integrity, utilizing a double-blind, randomized, sham-controlled design to elucidate the effects of multi-session task-concurrent bihemispheric tDCS on domain-specific FMA-UE and FMA-Lower Extremity (FMA-LE), Action Research Arm Test (ARAT). Moreover, we explored neural correlates underlying bihemispheric tDCS on the targeted sensorimotor network using resting-state functional magnetic resonance imaging (fMRI) in these subacute stroke patients. Our previous study demonstrated that a single-session bihemispheric tDCS simultaneously modulated bilateral corticospinal excitability in subacute stroke patients with preserved MEPs, in which electrophysiological changes were predicted by the baseline contralesional-to-ipsilesional transcallosal inhibition ratio between the M1s [