Microvascular invasion (MVI)
MVI can be predicted with good performance (AUROC > 0.75) and is the only feature where every ROI set resulted in models that contain features from all feature groups. Figure For all targets except MVI, the models obtained using the Proposed pipeline that are most relevant for follow-up study involve only shape features or first-order features, and so MVI is the only target where texture features appear to be informative. MVI is a histopathological finding related to both vessel co-option (invasion of existing vessels) and angiogenesis and is a process occurring at the capillary length-scale, i.e., somewhat smaller than the CT voxel size, and so spatial variability in the structure of the vascular invasion processes may give rise to variations in pixel intensity that appear as altered image texture. Further study in the larger cohort is needed to further explore this hypothesis.Since the models discovered by the Proposed pipeline for this target involve features from all feature groups, this target benefits the least from using the Proposed pipeline. This is evidenced by the AUROC increase, smaller 