Dose modifications and dose delays
toxicity, toxicities, alopecia, Toxicity
ADVERSE REACTIONS, ALOPECIA, ADVERSE REACTION
Toxicity is classified according to NCI-CTCAE version 5.0; the dose modifications are made based on the grading given in the latter. The treatment must not be modified if adverse reactions occur which, according to the investigator's estimation, do not result in severe or life-threatening consequences (e.g. alopecia). Should several different toxicities appear simultaneously, the respective greatest dose reduction decrement should be applied. If an adverse reaction is unequivocally attributable to only one of the cytostatic agents the dosages of the other substances do not need to be modified. A further dose escalation is not permitted.In case permanent discontinuation or treatment interruption of more than two cycles of one of the substances is required due to toxicity, study treatment has to be terminated. The further treatment will be at the treating physician's discretion.