Randomised controlled trial
asthma-like symptoms

Primary outcome: difference between the intervention group and the usual care group in the percentage of well controlled asthma-like symptoms after 1- and 2-year follow-up. The percentage well controlled asthma-like symptoms will be based on the validated TRACK questionnaire.Secondary outcomes: differences after one year and at the end of the study between the intervention group and usual care group will be assessed with respect to:Number of exacerbationsLung function (spirometry) at 6 years of ageAirway resistance with forced oscillation techniqueQuality of life of children and their parentsPharmacotherapy (frequency and dosage of used medication)Growth velocity over 12, 24 and 36 months (cm/y), change in height SD scores over 12, 24 and 36 monthsPatient reported side-effects of medicationHealthcare resource use and –costs (standard and extra clinical visits, hospital admissions, referrals, laboratory tests, imaging tests)Costs outside healthcare (over-the-counter drugs)Absence of school and work (parents);