Strengths and weaknesses of the study
The current study represents the first randomized trial to measure the impact of targeting high-normal extracellular potassium levels on TBK. The study was open labelled, i.e., the patients were not blinded to treatment regimen, or the hypothesis of the main trial. The TBK and p-K measurements were all, however, analyzed by technicians blinded to study group assignments. Due to the low sample size and heterogeneous study population, larger studies with a number of subgroups are needed to confirm the generalizability of the findings.