Introduction
MR, hypertension, hypertensive, diabetic nephropathy
HYPERTENSION, DIABETIC NEPHROPATHY
Renin-angiotensin system (RAS) inhibitors, such as angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARBs), are recommended as first-line drugs for hypertensive patients with diabetic nephropathy mainly for their blood pressure (BP)-lowering effects [Esaxerenone is a new nonsteroidal MR blocker that has been approved in Japan for the treatment of hypertension and is now under development by Daiichi Sankyo Co., Ltd. for diabetic nephropathy [In statistics, this type of analysis into the mechanism of an agent is called “mediation analysis” and has been used in medical and psychological research [This 