End Points
initiation to disease progression or, death
DISEASE, DISEASE PROGRESSION, SECONDARY
The primary end point was the objective response rate (ORR), defined as the proportion of patients with complete response (CR) or partial response (PR) according to RECIST v1.1. The secondary end points included PFS, defined as the time from treatment initiation to disease progression or death from any cause; overall survival (OS), defined as the survival time until death from any cause; duration of response (DoR), defined as the time from the first evidence of response to disease progression or death; disease control rate (DCR), defined as the proportion of patients who achieved CR, PR, or stable disease; and safety evaluation.Efficacy analysis was performed in the intention-to-treat (ITT) population. Safety analyses were performed on all patients who received at least one dose of study treatment.