Midfrontal theta power and response inhibition
PD
Midfrontal theta activity reflects cortical correlates of cognitive control which may be exerted via synchronized activity in a prefrontal-subthalamic network (Since 60 Hz-DBS increased preparatory midfrontal theta activity in contrast to off-DBS state and reduced the probability of reflexive errors compared with both off-DBS state and the 130-Hz condition, our results provide first preliminary evidence that mid-frequency DBS may improve response inhibition by enhancing proactive cognitive control in PD via midfrontal theta oscillations. Needless to say, a causal link between these findings cannot be implied based on the design and findings of our study. Beyond that, no significant correlation between the trial-by-trial outcomes of the behavioral and EEG analysis was detectable. Our interpretation of these findings, hence, needs to be confirmed in the future by larger studies.