Conclusions
dyspnea, COPD
COPD, OXIDATIVE STRESS
In conclusion, our results suggest that sequential NIPPV + IMT treatment alleviated dyspnea and improved exercise tolerance and quality of life in COPD patients, which might be related to reduced levels of oxidative stress mediated by SOCS5/JAK2/STAT3 signaling pathway. Our proposed a new and more effective therapeutic strategy for COPD patients and elucidated its potential pathways of action, providing a direction for the clinical treatment of patients with COPD.