Ethical consideration
Ethical clearance was obtained from the Ethical Review Board (ERB) of the Nepal Health Research Council (NHRC) (Ref. 3322). Similarly, the clinical trial was registered to clinicaltrilregistry.gov (Identifier: NCT04985396, registered on 02/08/2021). Formal permission was obtained from the Nepal Orthopaedic Hospital, Kathmandu, Nepal to conduct the study at their site. We constituted a Data and Safety Monitoring Board (DSMB) consisting of two orthopaedic surgeons and one statistician. The DSMB members prepared study-stopping rules and reviewed all the possible effects reported. The respondents were informed about the purpose of this study. The signing of informed consent was taken from eligible participants. Voluntary informed participation and freedom of refusal at any time during the study were strongly applied so that participants could withdraw from the study at any time without giving a reason and without fear. Privacy and confidentiality of collected information were ensured at all levels.