Inhibition of HIV-1 and HSV-2 
PD, HSV-2
For anti-HIV percent inhibition in vaginal fluid, median values at baseline were similar between the time point groups (p = 0.75). In addition, at post treatment visits, median HIV-1 and HSV-2 inhibition by vaginal fluid was similarly high whether obtained at 4 hours post dosing (Group 1) versus 24 hours post dosing (Group 2) (p = 0.83). As shown in Ex vivo PD modeling of anti-viral effect in vaginal fluid. 