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The PN used in this clinical study was Conjuran® (PharmaResearch, Gangneung-si Kangwon-do, Republic of Korea). A prefilled syringe containing 2 ml of viscoelastic PN solution 20 mg/ml that was extracted from salmon. It was approved as a medical device in Korea for physical viscosupplementation in patients with knee OA. The HA used in this study was Hyruan Plus