Subgroups analyses
obesity, fatty liver, SE
OBESITY, FATTY LIVER, LIVER, DIABETES MELLITUS, REGRESSION, METABOLIC SYNDROME
Next, to quantify the magnitude of the effect size in the change in the Li mAge in subgroups, we examined specific subgroups of interest in a sex and intervention stratum. For this analysis, we used morbidity/risk data collected in the DIRECT PLUS: fatty liver, diabetes mellitus, metabolic syndrome, obesity, and age dichotomized at 50, as age 50 emerged as the most prominent threshold for changes in brain anatomy in our cohort [Biological aging across the intervention groups in subgroups of health status, men only. Forest plot showing the mean and SE of 18-month change in Li mAge. Data presented as mean and SE across health status and diet subgroups. The presence of DM was defined for participants with baseline fasting plasma glucose levels ≥ 126 mg/dL or hemoglobin-A1c levels ≥ 6.5% or if regularly treated with oral antihyperglycemic medications or exogenous insulin. Liver status was based on MRI-measured live fat, as published before [Finally, we examined the differences between the observed Li mAge at the end of the intervention and the expected mAge using the baseline linear regression of Li mAge ~ age, as previously demonstrated by us [