Statistical analysis
malignancy
Mean ± standard deviation or median and interquartile range (IQR), and absolute numbers and relative frequencies (%) were used as descriptive statistics for continuous and categorical variables, respectively. Categorical outcomes were compared using Pearson's chi-squared or Fisher's exact tests, where appropriate. Nonparametric continuous variables were compared using the Mann–Whitney McNemar's test was applied to compare sensitivities and specificities between tests. Observed pathogenic molecular alterations are tabulated and grouped according to high (∼95% to 100%), intermediate (∼30% to 80%), and low (∼<30%) rate of malignancy (ROM).