Time to enrollment and symptoms at diagnosis/enrollment
fatigue, PET-MF, PPV-MF, insomnia, PMF
Median time from confirmed diagnosis to enrollment was 24.5 months, with PMF patients being enrolled into the trial after a shorter interval than patients with PPV-MF or PET-MF. The most common symptoms listed by physicians as reasons for suspecting MF were abnormal lab results and an enlarged spleen, followed by general weakness and formal constitutional symptoms. At trial enrollment, most patients suffered from fatigue, inactivity, and insomnia (Fig. MPN-SAF questionnaire results at baseline. Mean with SEM (