Ethics
The study protocol was approved by the local ethics committee, the Guangzhou Women and Children’s Medical Centre Ethics Committee, Guangzhou, China, on March 11, 2022 (reference number 2021-232B00, Chairperson Professor Sitang Gong). The protocol was registered at the Chinese Clinical Trial Registry (Registration number: ChiCTR2200055928, Date of registration: 26/01/2022) before the start of enrollment on 14/03/2022. This study complied with the Consolidated Standards of Reporting Trials (CONSORT) guidelines. All participants provided written informed consent prior to study commencement.