Introduction
Neuroinflammation, cognitive or perceptual impairment, Delirium, trauma
INFLAMMATORY RESPONSES
Delirium is a dysfunction of attention, thought and consciousness accompanied by changes in cognitive or perceptual impairment. Patients often have an acute onset and the condition is fluctuating [Neuroinflammation is a possible pathophysiological mechanism of POD. Stress reactions caused by trauma, surgery and anesthesia often activate the immune system non-specifically and are characterized by increased neutrophil counts [In addition to improving hemodynamic parameters, hypertonic saline (HS) has potential immunomodulatory effects to modulate local and systemic inflammatory responses [