Exercise intervention effects
death, hypertension-induced adverse
ELEVATED BLOOD PRESSURE, EVENTS, HYPERTENSION
This randomized controlled 16-week intervention trial supports the hypothesis that the cerebrovasculature is sensitive to exercise adaptation early in hypertension, independent of blood pressure changes, and exercise may help counteract hypertension-induced adverse remodelling. In this study, young adults with elevated blood pressure showed on average an increase in ICA and MCA M1 lumen diameter following supervised aerobic exercise. The increase in ICA lumen diameter over the course of the exercise intervention was associated with local increases in CBF.Risk of vascular events and death increases at both extremes of brain arterial diameter sizes (There were no significant differences in voxel-wise CBF at rest between the exercise intervention group and the control group. Previous studies investigating relations between physical activity and CBF show mixed results. A In the whole trial, no significant changes in blood pressure were seen in response to exercise (