Ethics of human subject participation
This manuscript forms part of a PhD thesis. The study was conducted according to the guidelines laid down in the Declaration of Helsinki, and all procedures involving research study participants were approved by the North-West University Health Research Ethics Committee (NWU-00452–19-A1) and was registered on the clinicaltrials.gov (NCT05168085). Permission was sought from the South African National and Provincial Department of Health, the local clinics in the study area and the community leaders to do the study. Written informed consent was obtained from all parents/legal guardians.