Interpretation
HYPERSENSITIVITY REACTIONS
Many of our results are in line with previous findings. Studies evaluating various IV iron preparations for the treatment of IDA in pregnant women have shown consistent improvements in maternal haematological parameters and suggest that hypersensitivity reactions are rare [The oral iron group was highly compliant but, even so, 20 (20%) women in the group had IDA at the 6 and/or 12-week visit(s). Outside a trial setting, it is plausible that compliance would have been lower, probably leading to more severe ID and maybe even IDA in a larger number of women than observed in this trial. Although the ferritin increase in the IV iron group was, initially, rapid, ferritin levels before treatment and at Week 18 of follow-up were similar in most women. This probably indicates that some women needed additional iron treatment, which may be appropriate to administer before ferritin returns to pre-treatment levels.Few previous trials of IV iron in pregnancy have explored PROs [