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Mesothelin is a cell surface glycoprotein that is normally expressed on mesothelial cells lining the pleura, peritoneum and pericardiumAdoptive cell therapy using T cells engineered to express chimeric antigen receptors (CARs) has shown remarkable efficacy in several hematologic malignanciesCAR-T cell constructs include only one (CD3ζ) of the six distinct T cell receptor (TCR) subunits tethered to a co-stimulatory domain (for example, CD28 or 4-1BB) and are expressed as standalone signaling receptors in transduced T cells, physically and functionally removed from native TCRs