Author contributions
RECRUITMENT
Z.Zho., X.Y. and L.X. designed the trial and wrote study protocol. Y.H, Z.Zha., G.H., Z.X., B.L. and X.T. did the investigations, including the recruitment, follow-up, and data collection. J.H., B.L. and Y.H. contributed to data management and statistical analysis. Z.Zho., R.D.L., X.L., J.H., X.Y., Y.X., Z.L., X.W. and B.L. contributed to the interpretation of the data. R.D.L., J.H., X.L., X.Y., B.L. and Y.H. wrote the manuscript. All authors have read and approved the article. All authors contributed to the critical review and final approval of the manuscript. Z.Zho. is guarantor of this work and, as such, had full access to all data in the trial and take responsibility for the integrity of the data and the accuracy of the data analyses.