Significance Statement
renal deterioration, nephropathy
DISEASE, NEPHROPATHY
Mesoamerican nephropathy is a rapidly progressive disease of unknown cause which is uniformly fatal. In this first-in-man study, SVF cells processed at the point of care can be safely injected into the renal artery. A subset of patients remain without renal deterioration 36 months after infusion. To our knowledge, no other therapy has been demonstrated to have an effect in slowing or halting the progression of this disease