Introduction
colorectal cancer, CIPN, Chemotherapy-induced nerve damage
CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY, COLORECTAL CANCER, ADVERSE EFFECT
Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse effect of platinum-based derivatives such as oxaliplatin. CIPN can limit the ability to tolerate treatment and can negatively affect patients’ long-term quality of life and physical functioning.Chemotherapy-induced nerve damage occurs in two phases, acute and long-term, with differences in timing and symptom trajectory.Factors that predispose CIPN, that have been reported previously, include age >65 years,SCOT was an international, multicentre (244 centres), randomised clinical trial that tested non-inferiority of 3 months versus 6 months of adjuvant oxaliplatin-containing chemotherapy in 6088 people with high-risk stage II and III colorectal cancer recruited between March 2008 and November 2013.