Design
This randomised cross-over study (AB/BA design) forms part of a wider study assessing the possible health effects of using novel nicotine and tobacco-containing products compared with smoking cigarettes and not smoking at all. The current analysis focuses on determining differences in cigarette-related withdrawal relief, product satisfaction, and risk perceptions for NVPs compared with HTPs among cigarette smokers naïve to using these products. Two questionnaires were administered to participants (before and after product use) at each of two laboratory visits at University College London, lasting approximately 1 h each. The wider study also involved the collection of biological samples, not reported here. Participants were reimbursed for time and travel.