Data collection
Routinely measured physiological data were collated through the 10-day study period. Medications administered to the patient each day were recorded, as were details of energy and protein prescribed and received (from feed, propofol and additional glucose), enabling total calories and grams of protein delivered, the percentage of target calories and protein delivered, and nutritional delivery to be compared between the two arms. Where possible functional milestones (days before Bed-to-Chair transfer and Sit-to-Stand times; 6-Minute Walk Distance and Short Physical Performance Battery) were collected at ICU/hospital discharge. Length of mechanical ventilation, ICU and hospital stays, and hospital discharge destination were collected and noted from medical records. Follow-up data (health-related quality of life; employment and primary care usage) were collected at 3-,6- and 12-months post-ICU discharge if relevant staff were available given COVID-19-related limitations. Data were collected initially into a paper Case Report Form and then transferred in anonymised form to a secure database.