Participants
Hypertensive, diabetes mellitus
DIABETES MELLITUS, SECONDARY HYPERTENSION
Hypertensive patients aged between 40 and 70 years, of both genders, in regular use of antihypertensive drugs, were selected from our outpatient clinic (Rio de Janeiro city, Brazil) and admitted to a randomized, crossover, placebo-controlled study. The exclusion criteria were secondary hypertension, use of beta-blockers or statin, diabetes mellitus or hormone replacement therapy. The local Ethics Committee approved all procedures, and all the participants signed the informed consent. This trial was registered at ClinicalTrials.Gov (NCT04020796).