Ethics approval and consent to participate
The animal study was approved by Ethical Committee of Nanchang Royo Biotech Co., Ltd (reference number RYE2019121702). All experiments were performed in accordance with relevant guidelines and regulations. The study is reported in accordance with ARRIVE guidelines ( The clinical experiment was approved by the Institutional Review Board (IRB) of the Second Affiliated Hospital of Nanchang University, registered in the Chinese Clinical Trial Registry (registration number: ChiCTR1900022522), which was conducted according to the ethical principles of the Declaration of Helsinki and Good Clinical Practice guidelines. All participants in clinical experiment also provided a signed written informed consent.