Introduction
TYPE 1 DIABETES, NEURODEGENERATIVE DISEASES
Modest structural and functional changes to the brain occur in children and young adults with type 1 diabetes (T1D).We have previously developed machine learning–based strategies to differentiate brain aging from neurodegenerative processes by deriving indices from 10 216 harmonized brain MRI scans assembled for the Imaging-Based Coordinate System for Aging and Neurodegenerative Diseases (iSTAGING) consortium.