Clinical parameters
At the first visit, all demographic data were recorded. At the randomisation visit, a fasting blood sample was taken in order to determine the NTproBNP level, serum sodium level, HbA1c and fasting plasma glucose as well as other biochemical safety parameters (e.g. serum creatinine, eGFR). Twenty-four-hour urine was collected to assess the urine volume, sodium as well as glucose excretion over 24 h. The 24-h urine collections were primarily frozen in order to keep the double-blind aspect of the trial maintained, the analyses were performed after the end of the trial.Office BP and heart rate was assessed after 5 min of rest according to guidelines [