Profile of mood scales (POMS)
tension/anxiety, anger/hostility
TSD
The Profile of Mood Scales (POMS) total score (mean [SD]) at baseline (day -1) was 38.9 [16.2] for group A (JNJ-54175446 early start); 34.4 [15.9] for group B (JNJ-54175446 late start) and 32.4 [15.7] for group C (placebo).The average POMS total score (SD) decreased following TSD and recovery sleep from day 4 to day 5 in group A from 33.9 (17.8) to 15.9 (17.7), in group B from 35.6 (16.9) to 13.0 (20.2) and in group C from 31.1 (10.8) to 9.9 (14.8). Reductions were observed for the individual sub-scales: tension/anxiety, depression/dejection fatigue/inertia, anger/hostility and confusion/bewilderment, but an increase in was found for the positive mood descriptor vigor/activity. These changes were consistent across all treatment groups, indicating that there was no clear interaction between TSD effect and JNJ-54175446 treatment. The average POMS total score (SD) on day 10 was 17.8 (17.5) for group A; 17.5 (20.6) for group B and 10.8 (13.0) for group C.