Discussions
In this study, baseline electrocardiographic intervals significantly correlated with 6-hour values. QT and QTc at 6 hrs and 336 hrs (Day 14) correlated well with pre-treatment value. Electrocardiographic monitoring at 6 hours may be a most important single point measurement of assessment of the electrocardiographic changes in the heart following use of halofantrine. Halofantrine, a phenantherene methanol has a half-life of 4 days and is metabolized to an active metabolite, N-desbutylhalofantrine by cytochrome P 450 (CYP3A4). Subjects, who were healthy volunteers, were not on any of the drugs known to be associated with prolonged QT interval and the serum potassium levels were within normal limits.Concomitant intake of kolanut with halofantrine was found to significantly decrease Cmax and AUC of both halofantrine and the metabolite desbutylhalofantrine