Discussion
Traumatic cervical SCI, long-term disability
Traumatic cervical SCI may lead to long-term disability for which cost-effective rehabilitation options are critically needed. The DiSCIoser study aims at providing evidence for the clinical/neurophysiological efficacy of BCI-based intervention to promote meaningful cortical sensorimotor plasticity and eventually maximize recovery of arm functions in subacute cervical SCI. This study will generate a body of knowledge that is fundamental to drive optimization of BCI application in SCI as a top-down therapeutic intervention (taking advantage of brain plasticity), thus beyond the canonical BCI use as assistive tool (i.e., neuroprosthetic controller).