Statistical analysis
SECONDARY
All statistical analyses were performed in SPSS version 24.0 by an independent statistician who was blinded to group allocations. Between-group differences in the demographic characteristics were compared. The Group × Timepoint interaction effect on the outcome measures was tested with a linear mixed model (LMM) for repeated measures. In addition, minimal clinically important differences (MCIDs) were computed for the CCT and control groups. The MCID threshold was set at 0.5 standard deviations [Between-group differences in the mean changes in the secondary measures, i.e., SC-FC coupling, and network-level topological properties were tested with a generalized linear model (GLM) while controlling for age, gender, and years of education. The tests for the main effects and multiple comparisons were two-tailed, and statistical significance was set at 