Proteomic data processing
To generate spectral libraries, 24 data dependent acquisition (DDA) measurements were performed on the urine samples. DDA spectra were searched using MaxQuant against the UniProt Human Database (December 2014, 88,657 entries) and the indexed retention time standard peptide sequence. A spectral library was generated using the spectral library generation feature from Spectronaut 10 (Biognosys, Schlieren-Zurich, Switzerland) and DIA data from individual samples were analyzed. First, the DIA raw files were converted into HTRMS format using the GTRMS converter tool provided by Spectronaut. The false discovery rate (FDR) was estimated using the mProphe [