L-citrulline and L-arginine in critically ill patients
We believe that L-citrulline administration along with a significant increase in plasma L-arginine concentrations is not harmful to medical ICU patients the way it is in other patients [Importantly, L-citrulline administration significantly increased plasma levels of L-arginine, suggesting it could be an interesting therapeutic in critical conditions associated with L-arginine deficiency, which itself has been associated with mortality [