Intervention description {11a}
stroke
STROKE, CORTEX
High‐frequency rTMS will be applied to the ipsilesional motor cortex in 400 bursts of 100 Hz triplets with a mean inter‐burst interval of 3 s (20 min treatment duration, 1,200 pulses per day) for five consecutive workdays (6,000 pulses total), followed by 40 min task‐specific hand/arm‐physiotherapy. The physiotherapy will be applied at all study centers according to a uniform standard operating procedure, which is based on standard treatment procedures in stroke care. Stimulation will be provided in a dedicated room by a GCP‐qualified trial physician or trial technician under supervision of a medical doctor. For the primary endpoint, FMA-UE raters will be trained to improve inter-rater reliability.This trial has one Experimental Condition and the Control Conditions 1 and 2. The three conditions will be randomized 1:1:1. All conditions target the hand representation of the ipsilesional motor cortex.