Estimand for the PLUSS primary outcome
ICH, Death, BPD
The addendum to the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) E9 (R1) guidelines [Primary outcome for the PLUSS trial presented in the estimand framework (table layout based on the proposed estimand framework reporting proposed by Kang et al. [Death, or physiological BPD if any of the following criteria are met:1. Receiving mechanical ventilation via an endotracheal tube, CPAP, NIPPV, or nasal high-flow ≥ 2 L/min, regardless of FiO2. An effective FiO3. An effective FiOFor infants receiving oxygen by nasal prongs at < 2 L/min, the effective FiO