Introduction
obesity, Binge-eating disorder, weight loss
OBESITY
Binge-eating disorder (BED) is a prevalent (Kessler et al., Despite the high morbidity associated with BED, it remains underrecognized, and most people with BED go untreated (Coffino, Udo, & Grilo, In contrast to the growing evidence base for treatments with acute efficacy for BED, there is a dearth of controlled research examining maintenance treatments for responders to initial interventions. This gap in the literature appears particularly critical for pharmacological approaches for BED, which – in contrast to certain specific psychological treatments (Grilo et al., This report describes a prospective, randomized, double-blind, placebo-controlled test of the efficacy of naltrexone/bupropion maintenance treatment following successful acute treatments for BED comorbid with obesity. Naltrexone/bupropion combination is an FDA-approved medication for the treatment of obesity (Yanovski & Yanovski, We hypothesized that participants receiving naltrexone/bupropion would maintain reductions in binge-eating frequency and weight loss attained with acute treatment while participants receiving placebo would show increases in binge-eating frequency and in weight. We hypothesized that initial acute treatment condition (naltrexone/bupropion or BWL therapy) would moderate these maintenance treatment outcomes.