Introduction
cancer, death
CANCER, SOLID TUMORS
Synthetic lethality is an important concept in precision oncology that is exploited to selectively kill cancer cells. It refers to a genetic interaction whereby loss or inactivation of either of 2 genes does not impact cell viability, but simultaneous loss or inactivation of both leads to cell death.A variety of solid tumors harbor alterations in BRCA genes.Senaparib (formerly IMP4297) is a novel oral PARP(1/2) inhibitor that demonstrated strong antitumor activity in preclinical studies, and particularly in BRCA