Limitations
SECONDARY, LEFT VENTRICULAR DIASTOLIC DYSFUNCTION
The present study is a small, single-center study with a duration of only 6 months, and thus, is restricted in its ability to predict long-term changes in risk. Furthermore, the study is an exploratory analysis based on data from the MIRAD trial. Although the study focuses on left ventricular diastolic dysfunction, all outcomes are either secondary outcomes prespecified as part of trial design or defined post-hoc. As an effect – and in consideration of multiplicity of testing—results must be viewed as hypothesis-generating and in need of corroboration. Finally, the present study contained a large proportion of patients with no signs of either overt systolic or diastolic function, with a long-standing stable clinical condition, which lowers the expected effects size of treatment. Considering the results of PARAGON trial [