Introduction
death, COPD
COPD, COPD EXACERBATION, EVENT, CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death worldwide (7.5–10%)If an acute exacerbation could be predicted and preparations could be made in advance, the individual and social burdens, as well as adverse outcomes, would be reduced. Several prediction models have been proposed for COPD exacerbation. In many cases, there models have not reached a sufficient level of high-quality statistical approachHere, we developed prediction model for subsequent exacerbation event by integrating several information regarding the risk of exacerbation, then sequentially performed externally validation to identify its predictive power and adequacy.