Digital quantitation and AI analyses of treatment-induced changes in steatosis, ballooning, and liver fibrosis
NASH, steatosis, fibrosis
LIVER FIBROSIS, STEATOSIS, FIBROSIS
Paired liver biopsies from 144 patients (TXRChanges in steatosis and liver fibrosis as assessed by NASH CRN scoring and by digital quantification from baseline to week 48. (A) In-depth analyses of fibrosis changes in different zones of liver lobule demonstrated that TXRTreatment-induced fibrosis changes in different zones of liver lobules and colocalization analysis of steatosis and fibrosis changes from baseline to week 48. (A) Digital quantification of fibrosis dynamics as a percentage change of fibrosis area in different zones of the liver lobule. The periportal and pericentral areas are set at 100 µm from the portal tract and the central vein, respectively, and the region in between is the Zone 2 area. There were no notable changes in the number of ballooned hepatocytes from baseline to week 48 with any of the 4 treatment regimens, irrespective of whether patients had a high or low number of ballooned hepatocytes. (Supplemental Figure S5A, 