Ethics approval and consent to participate
The present study was approved by the Research Committee of Iran University of Medical Sciences with the code: IR.IUMS.REC.1399.1417. It was also registered in the Clinical Trial Registration Center of Iran, with the code: IRCT20180427039436N9 in 14/04/2021. Written informed consent was obtained from the participants who were completely informed of the study purposes and procedures. In addition, the participants were assured about the confidentiality of their information. All the experiment protocol for involving human data was in accordance with the guidelines of the Declaration of Helsinki in the manuscript.