Development and validation of the nomogram
CSS-associated, NRI
EPITHELIAL OVARIAN CANCER
According to the identified independent prognostic factors, we constructed nomograms for elderly patients with EOC to predict 3-, 5-, and 10-year OS as well as CSS. The total score of all variables was calculated and then the 3-, 5-, and 10-year probability of OS and CSS could be concluded consequently. Figure Nomograms to predict 3-, 5-, and 10-year overall survival and cancer-specific survival for elderly patients with epithelial ovarian cancer. *C-index and calibration curve were carried out to assess the overall performance of the two nomograms. The C-index was 0.713 (95% CI: 0.701–0.725) in the training cohort and 0.751 (95% CI: 0.731–0.771) in the validation cohort for the prediction of OS, respectively. Moreover, the C-index for the prediction of CSS was 0.729 (95% CI: 0.717–0.741) and 0.702 (95% CI: 0.680–0.724) in the training and validation groups (Table The NRI, IDI, and C-index of the nomograms and AJCC Stage system in OS and CSS prediction for elderly patients with EOCCalibration plots of 3-, 5-, and 10-year OS (The receiver operating characteristic curves (ROC) showed that the values of AUC at 3-, 5-, and 10-year for the prediction of OS were 0.738, 0.770, and 0.782 in the training group and 0.745, 0.749, and 0.757 in the validation group, respectively. Meanwhile, the 3-, 5-, 10-year AUC in the training cohort and validation cohort were 0.740, 0.771, 0.775 and 0.750, 0.752, 0.752 for the prediction of CSS (Fig. Time-dependent ROC curves of the nomogram for 3-, 5-, and 10-year predictions. AUC for predicting OS in the training set (Decision curve analysis of the OS-associated and CSS-associated nomograms. DCA curves of 3-, 5-, and 10-year OS in the training cohort (