Patient population
Headache, temporomandibular disorder, pain, CM, headache, migraine, uncontrolled/untreated psychiatric
HEADACHE DISORDERS, CARDIOVASCULAR DISEASE, TEMPOROMANDIBULAR DISORDER, SYNDROMES, OTHER HEADACHE, MIGRAINE
Adults 18–75 years old (inclusive) with migraine onset at 50 years old or younger were eligible for participation if their migraine diagnosis met the criteria established in the International Classification of Headache Disorders, 3In this study, a migraine day was defined as any day with a headache that meets the CM definition as outlined in the International Headache Society guidelines (section 1.3.1.1) [Adults were ineligible for study participation if previous anti-CGPR treatment(s) failed or if they had confounding and clinically significant pain syndromes, an acute or active temporomandibular disorder diagnosis, other headache type diagnosis, clinically significant cardiovascular disease, or an uncontrolled/untreated psychiatric condition for ≥ 6 months prior. Full inclusion and exclusion criteria are detailed in the protocol.