Six-Gene Whole Blood RNA Score
Four responders and 4 non-responders had paired pre- and post-treatment samples available for peripheral blood transcriptional profiling. No clear pattern of change was noted in the 6–gene signature scores in both the responder and non-responder groups (Changes in individual patients’ 6–gene signature scores over the course of satraplatin treatment. Responders (achieving ≥30% decline in serum PSA) are shown in blue, non-responders shown in red.Maximum percentage change to each patient’s 6–gene score was compared to the maximum percentage PSA change and visualized in a paired waterfall plot (Maximum changes in PSA levels (blue) displayed as a waterfall plot, with associated 6–gene signature score changes (red) displayed adjacently. The 6–gene scores were calculated for patients that tolerated at least 2 cycles of satraplatin treatment. (+) denotes a PSA change >100%. (*) no follow up PSA labs available for comparison to baseline PSA.