Author contributions
WL
LG, QP, and XW conceived the experimental strategy, which was further developed by QZ, WL, XC, and YLZ. ZW researched data, contributed to the discussion, and WW provided statistical support. JH, W-HH, and Y-TY contributed to animal studies. YH, YJZ, and LL prepared the manuscript with input from all co-authors. All authors participated in the preparation and review of the manuscript. LG is the guarantor of this work and, as such, had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. All authors contributed to the article and approved the submitted version.