2.1. Study Design
periodontitis
PERIODONTITIS, SYSTEMIC DISEASE
The study is a double-blinded, randomized, prospective, split-mouth study. A total of 10 subjects visiting the department of Periodontics, SRM Kattankulathur Dental College and Hospital, presenting with generalized stage III grade B or C periodontitis (AAP 2017) having one or more vertical osseous defects were enrolled in the study. Patients with good oral hygiene compliance, at least 2 periodontal pockets with probing depth (≥6 mm) on contralateral side of the same arch or on the opposite arch after Phase I Therapy and at least 2 intrabony defects in interproximal areas with radiographic evidence of intrabony compartment (≥4 mm) on contralateral side of the same arch or on the opposite arch were included as part of the study. Patients with systemic diseases that might influence periodontal conditions, pregnant/ lactating mothers and those who received any periodontal treatment and medication for the past six months were excluded from the study. All the patients were duly informed about the procedure and informed consent was obtained. The study was approved by the Institutional Ethical Committee of SRM Dental College, Chennai. (Ethical Approval number: 895/IEC/2015). The bilateral sites were randomly assigned into two groups, Group A—AmnioGuard