Introduction
a reduced regional CBF, hyper-responsivity, nausea and, pain, tiredness, migraine
MIGRAINE, DISEASE
Not just pain, but also intolerance to sound and light, nausea and vomiting, tiredness, and difficulties with concentration are hallmarks of migraine attacksGiven the correlation between metabolic activity and blood flow, perfusion studies allow for the monitoring of disease activity and treatment response and thus help to deepen our understanding of the disorderDuring the interictal periodThis hyper-responsivity may be favoured by deficient habituation of cortical responses to repeated stimuli, which itself is promoted by a lower interictal pre-excitation level of sensory cortices in episodic migraineThis study investigates the cortical perfusion of episodic migraineurs and healthy controls and the influence of anodal tDCS on interictal CBF in episodic migraineurs. We hypothesised that a therapeutic modification of cortical excitability induces a reduction of hyper-responsivity that manifests as a reduced regional CBF.