Ethics
Prior to their inclusion in the study, informed consent was obtained from all participants. The study was conducted in accordance with the principles and all the subsequent amendments of the declaration of Helsinki. The Swedish Ethical Review Authority in Uppsala approved this study with diary number 2018–568 and diary number 2019–00133. Additionally, the clinical trial has been registered at ISRCTN under the number 73,435,627; 10.1186/ISRCTN73435627.