Conclusion
The contribution of artefenomel exposure to Day 28 PCR-adjusted ACPR could not be demonstrated. The main reason was likely the higher than anticipated efficacy with ferroquine alone which reduced the power of the study to identify the contribution of artefenomel to the drug combination, rather than a true lack of contribution. More rapid parasite clearance was demonstrated with the artefenomel/ferroquine combination compared to ferroquine alone, clearly showing the contribution of both drugs to parasite clearance. The combination was generally well tolerated, and the safety profile was consistent with the known profiles of the two compounds.