Virtual screening and docking methods
Based on bioinformatics analysis and enrichment tools, we manifested that ADIPOQ and IL-6 are cut-point nodes in the hub genes network and could be druggable drug design and treatment candidates. Accordingly, we browsed the UniProt database [The molecular docking method was conducted in the PyRx software to determine suitably binding affinity between small molecules and druggable candidates in the dimensional search space. In this study, we authorized binding affinity score < − 5 and RMSD < 2 as suitable affinity [