What is already known about this topic?
Nirmatrelvir/ritonavir (Paxlovid) is recommended for treatment of mild-to-moderate COVID-19 in adults at high risk for progression to severe COVID-19. Rebound in SARS-CoV-2 shedding or COVID-19 signs and symptoms has been described after nirmatrelvir/ritonavir treatment, although the drug’s direct contribution to rebound remains unclear.