Change in outcomes over time
Pain, Fatigue
DISEASE
LSM changes in CDAI, SDAI, DAS28-CRP, RAPID3 and HAQ-DI demonstrated statistically significant improvements from baseline within each treatment group (T2T and RC) as early as month 3 and were sustained through month 12 (Least squares mean (LSM) change from baseline in disease outcomes through 1 year. In the overall population, the absolute mean change in disease measures and PROs from baseline to months 3–12 ranged from -5.3 to -6.5 for TJC28, -4.6 to -6.0 for SJC28, -14.5 to -21.2 mm for Pain, and -14.6 to -19.8 mm for Fatigue. Over time, no significant differences in levels of these parameters were observed between the treatment groups (Figure S