Statistical Analyses: Comparisons of Treatment Groups for Symptomatic Outcomes
depression, hypo/mania
Details of the statistical modeling are described elsewhere [Using repeated measures mixed-effect models, we examined the main and interactive effects of treatment (FFT-HR versus EC) and study assessment visit (every 4 months in year 1 and every 6 months thereafter) as predictors of depression or hypo/mania (mean weekly PSR) severity scores. In mediational analyses, we examined changes in family functioning as measured by the child’s reports on the Conflict Behavior Questionnaire (CBQ) and the Social Adjustment Scale-Self Report as mediators of the association between treatment condition and PSR scores from baseline to post-treatment and end of follow-up. To model mediation effects, PSR scores at follow-up were regressed on treatment group and youth’s CBQ or Social Adjustment Scale scores from the prior 4-6 month assessment interval, with random intercepts and slopes fitted within-subject. Indirect effects were estimated and bootstrapped with 1000 iterations to test the effects of the treatment group on PSR scores 