Efficacy measures
Efficacy assessments were performed on the intent-to-treat (ITT) population, defined as all randomized subjects who received at least one dose of double-blind study medication and had at least one postdose assessment of the primary efficacy variable (SKAMP-C). The SKAMP-C (Wigal and Wigal, The PERMP is a 5-page timed written test that measures the number of math problems attempted and solved correctly in 10 minutes (Wigal and Wigal, Efficacy assessments were collected at predose, 1, 2, 4, 6, 8, 10, 12, and 13 hours postdose. The primary efficacy outcome was the onset of efficacy for AMPH EROS compared with placebo as assessed by the primary outcome measure, SKAMP-C scores (Childress et al, 