Developing mucoadhesive tablets
Mucoadhesive tablets were produced in the laboratory of Mazandaran medical university (Faculty of pharmacy). 10-mg atorvastatin mucoadhesive tablets were prepared with different proportions of the medicine and bioadhesive polymers such as HPMC or CMC. Tablets were prepared by direct compression method after weighing and complete mixing of medicine, polymer, and other excipients such as Avicel as a filler, Colloidal silicon dioxide as a glidant, and Magnesium stearate as a lubricant.In the present study, atorvastatin was manufactured by Tehran Chemical Company, Avicel was produced by Saba Chemical Company, Magnesium stearate was developed by Axin Chemical Company in Iran, and Aerosol was manufactured by Avonic Company in Germany.