Authors’ contributions
MR
HS, MBK, OH, and CEW conceived the study. CEW obtained funding for the study. MR and HS conducted the data analysis and interpretation of the clinical data. KSS performed the analyses of the 16 rRNA gene sequencing data. AS conducted the analyses of the metagenomic data. KSS and AS analyzed the metabolomic data and produced the figures and tables included in the manuscript. KSS, AS, and CEW interpreted the generated data and wrote the original draft of the paper. MR, OH, and HS critically revised the paper. The authors read and approved the final manuscript.