Introduction
CF, a multisystem disease, CF respiratory tract, inflammation, CF disease
INFLAMMATION, LUNG DISORDERS, CYSTIC FIBROSIS, DISEASES, GENETIC DISEASE, CYSTIC FIBROSIS LUNG
CF is a chronic and progressive genetic disease that, as a multisystem disease, affects not only the lungs, but also the pancreas, liver, and digestive system [Moreover, the thick and adhesive mucosa which is typical feature of the airways with inflammation in cystic fibrosis might block the diffusion of Nitric Oxide (NO) from the synthetic area in the mucous layer to luminal air [Fractional exhalation of Nitric Oxide (FeNO) in CF patients is plummeted with normal or lung function reduction in comparison with non-CF control subjects, and lately it has been indicated that FeNO is inverse correlation with the lung-clearance index. The reason that FeNO is lowered in CF is still unclear, although hypotheses consist of locally trapped NO in the dense mucous lining characteristic of the CF respiratory tract, reduced production due to lack of NO synthase, rising NO consumption, or inadequacy in ciliary activity [To ease the elimination of Thick lung secretions, medicines that reduce mucous density and plasticity are frequently applied in various lung disorders, and particularly in CF [In addition to taking antibiotics in certain cases, the treatment for cystic fibrosis lung involvement is mucolytics to clear respiratory secretions (DNase and inhaled hypertonic saline) and chest physiotherapy [The upward trend of reduction rate upon antibiotics’ effectiveness makes it vital to address new therapeutic alternatives. Products acquired from plants are of interest regarding their health-improving and antimicrobial characteristics. Traditional and complementary medicines are origins of modern and often natural medicines. Out of various traditional classifications of Persian Medicine (PM) is one of the earliest and most precious ones. There is no CF disease in (PM) history, but because of the production of dense excretions in the body ducts, it is set in diseases category owing to the synthesis of thick and gelatinous secretions [The application of Persian Medicine syrup ingredients of “compound honey syrup” (CHS) included Honey, Honey contains the flavonoid components Quercetin, Kaempferol, Apigenin and Genistein [Cinnamon has anticholinergic, antimicrobial and anti-inflammatory effects [Since there have been no previous clinical trials investigating the effect of CHS on FeNO levels in CF patients. Consequently, we initiated this study with the aim of evaluating the effectiveness of CHS on FeNO levels in children with CF.