Randomization and blinding
A randomized, double-blind clinical trial was carried out where patients and dentists were unaware of which methodology was used to select the antibiotic as part of the periodontal therapy. In detail, after consent form approval, dental clinic staff responsible for the prescription of the periodontal antibiotic treatment assigned each patient a code, which was previously generated randomly by another research team member. Depending on the method of treatment selection, this code consisted of a patient number and a letter A or B. Thus, 32 patients were randomly assigned to one method treatment group, while the other 32 were assigned to the other group.