Results
TMA, Normal rectosigmoid colon
The experimental design and computational workflow are graphically described in Graphical abstract of study design and workflow. The panel illustrates the schematic of experimental design and workflow used in this study. Normal rectosigmoid colon biopsies were collected from 18 LS participants [placebo N=6, low dose (LD, 220 mg) N=6, high dose (HD, 440 mg) N=6]. Participants (N=18) provided a pre- and post-exposure biopsy samples (N=36 samples) for tissue micro array (TMA), which was used for image mass cytometry (IMC) and analysis. This figure was generated using Immune mass cytometry isolated discrete immune cell populations following tissue segmentation. Using data-driven exploration, unsupervised clustering by the Phenograph algorithm generated clusters of 165 cell populations (Chemopreventive naproxen increases activation of cytotoxic T-lymphocytes in the mucosa. 