Trial design
WEST
This randomized controlled single-center, double-blind, parallel trial was approved by the Biomedical Ethics Committee of West China Hospital of Sichuan University on 18/12/2019 (2019 − 928), and written informed consent was obtained from all subjects participating in the trial. The trial was registered prior to patient enrollment on the Chinese Clinical Trials Registry on 20/01/2020 (ChiCTR2000029247). Our study was conducted based on a prespecified protocol from January to October 2020 in accordance with the Helsinki Declaration-2013 [