Discussion
CF, cystic fibrosis, CFTR dysfunction
ADHESION, CYSTIC FIBROSIS
This study demonstrated the prescription of CHS to cause significantly increased FeNO in patients with CF. There was a noticeable difference between the results of FeNO before and after the intervention.Although in recent years, the use of complementary and alternative medicine has been considered among health care providers and some of the patients with CF use one of the complementary and alternative medicine methods due to its effectiveness upon symptoms reduction in CF patients [The ingredients of CHS also contain flavonoid components which have been shown to stimulate CFTR in various studies, and that include Quercetin, Kaempferol, Apigenin and Genistein in honey [As mentioned, one of the causes of FeNO reduction in patients with cystic fibrosis is the underlying CFTR dysfunction [Today, due to the presence of thick secretions in the lungs of patients with CF and the resulting many lung problems, the use of drugs that facilitate the clearance of pulmonary secretions is very important. The excretion of concentrated and purulent airway secretions in patients with CF is a common problem. Analysis of sputum in these patients sdorhows that its high adhesion is towing to macromolecules that include mucosal glycoproteins, modified DNA, and protein polymers [In our study, CHS caused FeNO changes in CF patients according to its ability to dilute thick and viscous secretions especially in the airways.In general, the results of the present study showed that CHS can be introduced as a complementary treatment with positive effects in increasing the amount of NO in exhaled air and not having significant side effects in CF patients. However, more studies and experiments are recommended to ensure this conclusion.