Methods
death
The data presented in this paper were acquired at the Kenya site as part of the Global Network for Women’s and Children’s Health Research ASPIRIN trial. Detailed study methods are described in Hoffman et al. [Map of the study region, located in Busia, Bungoma, and Kakamega counties of western Kenya. Study clusters are outlined in gray. County locations within Kenya are depicted in the inset mapEligible subjects were pregnant nulliparous women carrying singleton pregnancies. An early ultrasound was performed between 6 + 0/7 and 13 + 6/7 weeks gestational age for accurate pregnancy dating. From this ultrasound, the estimated day of delivery was determined using the ACOG algorithm [Infants born to subjects were weighed on platform scales either at a delivery in a health facility, or if born outside of a facility, at the home of the local village elder [For subjects experiencing either a stillbirth or an infant death before the 42-day follow-up period, the assumed cause of death was determined using a previously published algorithm [Statistical analyses were performed using JMP software and SAS version 9.4 (SAS Inc, Cary, NC USA). The 10A signed rank test was used to quantify the comparison of the percentiles generated in this study with those of the INTERGROWTH-21st study. This test was performed twice within each gestational week – once testing the null hypothesis that the Kenya Male median equals the reported median of the INTERGROWTH-21st Male data, and once testing the null hypothesis that the Kenya Female median equals the reported median of the INTERGROWTH-21st Female data. This analysis was non-directional and performed at the alpha = 0.05 significance level.