Drug exposure
There were no statistically significant differences between measured drug concentrations in plasma (or end-tidal air) between the connected and disconnected subjects within the treatment groups (Targeted and measured drug concentrations during the experimentMean (SD) targeted and measured drug concentrations in plasma or end-tidal gas in the propofol, dexmedetomidine, sevoflurane and S-ketamine groups. No statistically significant differences were observed in the measured concentrations between the responsive and unresponsive subjects (two-tailed 