Conclusions
OA, pain
This randomized, double-blind, placebo-controlled study evaluates for the first time the effect of continuous oral SPMs consumption on an adult population of symptomatic knee OA patients. SPMs supplementation reduced pain and improved the quality of life of OA patients. Our results do not support a long-lasting residual effect of SPMs after treatment, suggesting the need for continuous SPMs supplementation to maintain some of the clinical benefits. The results from this study support the favorable safety record of SPMs-enriched oil consumption.