Minimization
All patients underwent both AVS and MTO. The order that each participant underwent each investigation was determined by a minimization program within the study data center (Robertson Centre for Biostatistics, University of Glasgow), designed to maintain a balance with respect to study site, sex and age (<55 or ≥55 years). Both AVS and MTO were performed with the patient taking non-interfering medications such as doxazosin, verapamil and hydralazine, according to Endocrine Society consensus guidelines