Image acquisition
BRAIN
Brain MRI scans were collected from PwMS at baseline and at week 24 with Siemens 3-Tesla scanners (Siemens Healthcare GmbH, Erlangen, Germany) following optimized clinical practice protocols in place at the two investigating centers: (1) Hospital Universitari Vall d'Hebron, three-dimensional (3D) T1-weighted (repetition time [TR] = 2300 ms; echo time [TE] = 2.98 ms; inversion time [TI] = 900 ms; voxel size = 1 × 1 × 1 mm) fluid-attenuated inversion recovery (FLAIR; TR = 6000 ms; TE = 394 ms; TI = 2100 ms; voxel size = 1 × 1 × 1 mm) sequences acquired in a Siemens Trio Tim; (2) University of California San Francisco, 3D T1-weighted (TR = 2300 ms; TE = 2.98 ms; TI = 900 ms; voxel size = 1 × 1 × 1 mm) FLAIR (TR = 5000 ms; TE = 389 ms; TI = 1,800 ms; voxel size = 1 × 1 × 1 mm) sequences acquired in a Siemens Skyra.