2.4. Analysis and Modelling of Meal
POSITIVE
Insulin secretion (pmol × minBasal insulin secretion (pmol × minTotal insulin secretion (nmol × mThe parameters of the model were estimated from glucose and Incremental insulin secretion: was calculated as total insulin secretion − basal insulin secretion × duration of the study.Insulin clearance: was calculated in the fasting state as the ratio between fasting insulin secretion and fasting insulin concentration and during the meal as the ratio between the integral of insulin secretion and that of insulin concentration.Positive areas under the meal curve (AUC) were calculated by trapezoidal integration over the entire meal, only considering values above the baseline.