Natural history of RP among major genotypes.
RP, nonsyndromic disease
RECRUITMENT, PATHOPHYSIOLOGY, LOCALIZED DISEASE
As enrollment in the vitamin A study was performed without knowledge of the underlying genotypes, it provides an unbiased view of the genetic composition and natural history of RP. Some genetic causes of RP had been discovered by the time the additional participants were recruited for the lutein and DHA trials, but panel-based genetic testing had not yet been implemented. There were recruitment efforts for Starting amplitudes and rates of decline are shown in Specifically, it is worth noting that One limitation of these progression models, such as those in It was also notable that participants with This study did not estimate comparable progression rates by genotype for other outcomes, including visual field, visual acuity, or the mixed-response full-field ERG; comparing group differences and progression rates in these outcomes could be an area for future research. Additional areas of study could be comparison of syndromic versus nonsyndromic disease (In general, it remains a remarkable biological observation that the very particular and localized disease phenotype seen in RP can be caused by defects in so many different genes. While studies such as this one can dissect various important differences between the genotype subgroups in RP, the different genetic forms of RP are, overall, similar enough that it supports the theory of a shared underlying pathophysiology (