Safety
toxicity, pain
ADVERSE EVENTS
The safety findings were consistent with the known toxicity profile of radium-223. Five serious adverse events were observed, only 1 of which was possibly related to radium-223 (leg pain). No grade 4 or 5 adverse events were reported. Grade 3 adverse events were reported in 17 patients (9 in the 55-kBq/kg group and 8 in the 88-kBq/kg group).