5. Conclusions
coronary heart disease
DILATION, CORONARY HEART DISEASE
In this study, we demonstrated that EPA 460 mg and DHA 380 mg twice a day for 5 weeks improved vascular function assessed using flow-mediated dilation in hypertriglyceridemic patients without clinical symptoms of coronary heart disease and who were not receiving other drugs. Vascular function improvement was concomitant with an enrichment of HDL with EPA and DHA that did not affect the stability of these lipoproteins. The significant increase in the EPA-to-AA ratio in HDLs may contribute to the enhancement of the anti-inflammatory effects of these lipoproteins.