Introduction
cancer,, autoimmune diseases, erosions, pemphigus, infection, Pemphigus, blisters, autoimmune disease
INFLAMMATORY DISEASE, AUTOIMMUNE DISEASES, RECRUITMENT, PEMPHIGUS, INFECTION, SECONDARY, PEMPHIGUS, AUTOIMMUNE DISEASE
Pemphigus is a rare and life-threatening autoimmune disease that manifests as blisters and erosions on skin and/or mucosa. It is mediated by autoreactive B cells targeting desmoglein 1 (DSG1) and/or DSG3, the transmembrane binding proteins of desmosomes in keratinocytes (Tertiary lymphoid structures (TLSs), aggregates of T and B cells, resemble B cell follicles of secondary lymphoid organs (SLOs), such as the spleen and lymph nodes, and have been detected in the peripheral tissues in a variety of inflammatory diseases, including cancer, infection, and autoimmune diseases (Similar to B cell follicles in SLOs, TLSs have high expression of CXCL13, a chemokine responsible for the recruitment of CXCR5-expressing immune cells, such as naive B cells and T follicular helper (Tfh) cells (Here, we investigated TLSs containing DSG-specific B cells and plasma cells in chronic blisters from patients with pemphigus. We demonstrate upregulation of CXCL13, which is mainly produced by CD4