Introduction
STRICTURES, ESOPHAGEAL NEOPLASMS, DIGESTIVE SYSTEM NEOPLASM
Endoscopic submucosal dissection (ESD) is a popular intervention for digestive system neoplasms. Moreover, ESD is used to perform en bloc resection of entire oesophageal neoplasms, contributing to a precise pathological assessmentCurrently, endoscopic balloon dilatation, stent placement, oral steroid administration, and endoscopic steroid injection have been used prophylactically for strictures after ESDWe designed a novel gel consisting of a colloidal and fixative solution, to protect artificial wounds after oesophageal ESD. The colloidal solution is composed of poloxamers and sodium alginate, whereas the fixative solution contains calcium chloride. Poloxamers are synthetic nonionic triblock copolymers (PEO–PPO–PEO) of polyethylene oxide, and the most notable features of poloxamers include their temperature-dependent self-assembly and thermo-reversibilityIn this multicentre, randomized, single-blind trial, we investigated the effectiveness and safety of a novel gel designed to protect oesophageal wounds resulting from ESD.