Random allocation
The allocation of patients to the IP or PI group was conducted in a 1:1 ratio using the permutation random block method, with stratification based on the need for additional maxillary third molar extraction alongside mandibular third molar extraction. The block size was kept confidential to maintain blinding. The allocation sequence for the randomization method was generated by the biostatistician (T. I.). Patients, care providers, outcome assessors, and biostatisticians were blinded. Randomization was performed on all eligible patients who provided consent, met the inclusion criteria, and did not meet any exclusion criteria.