Introduction
ALL
ACUTE LYMPHOBLASTIC LEUKEMIA, ADULT ALL
The introduction of targeted therapies like the BCR::ABL1 tyrosine kinase inhibitors in Philadelphia-chromosome(Ph)-positive acute lymphoblastic leukemia (ALL), of immune-oncologic therapies like antibodies targeting CD19, CD20 and CD22, as well as chimeric antigen receptor T (CAR-T) cellular therapies in pre-B ALL, is transforming the therapeutic landscape in adult ALL [Single-arm and later randomized trials confirmed the efficacy of inotuzumab and blinatumomab as single-agent therapies in relapsed-refractory (R-R) ALL [To improve the results, we combined low intensity chemotherapy (mini-Hyper-CVD) with inotuzumab. We have previously reported that this regimen resulted in an overall response rate of 80% and a median OS of 11 months. A post hoc analysis from that study showed improved survival with the combination compared with single-agent inotuzumab (median OS, 9.3 vs. 5.6 months; 