Methods and materials
Digestive, Diabetes
MAY, KIDNEY DISEASES, PATHOPHYSIOLOGY, DIABETES
The Metformin Influences Gut Hormones in Youth (MIGHTY) studies were designed to evaluate the pathophysiology of Y-T2DM and metformin mechanisms of action. Y-T2DM subjects were recruited from and evaluated consecutively at the Metabolic Clinical Research Unit at the National Institutes of Health Clinical Center (NIH CC), Bethesda, MD, USA (ClinicalTrials.gov registration no. NCT04209075). The protocol was approved by the Institutional Review Board of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Parents provided written informed consent and youth gave assent prior to enrollment. Nine (9) participants were screened and 6 enrolled between February 2020 and May 2021 (