INTRODUCTION
VITREOUS HUMOR, SKIN CONDITION
Hyaluronic acid (HA) is an endogenous component widely distributing in the extracellular matrix of human body, with high concentrations in connective tissues such as skin, synovial fluid, and vitreous humor.With the emergence of HA dietary supplements, some researchers investigated the absorption and metabolism mechanisms of orally ingested HA. Studies showed that orally ingested high‐molecular‐weight HA (HMM‐HA, MW≥100 kDa) does not undergo significant degradation in gastric fluid,In recent years, clinical trials were carried out to reveal that oral administration of HA can effectively improve skin condition. Kajimoto et al., Sato et al.,However, previous studies have not further explored the effects of oral hyaluronic acid on different age groups and skin types. For example, young skin has relatively sufficient HA content, and oily skin has better moisture retention ability than dry skin. It is worth exploring whether oral administration of HA has the same positive effect on these types of skin. Therefore, a randomized, double‐blind test on 129 Shanghai healthy female panelists were carried out to investigate the clinical benefit of oral administration of HA.