Study procedures and schema
sarcoma, Cancer
TRANSLOCATION, SARCOMA, CANCER
The baseline investigations consisted of complete hemogram, organ function tests, Lactate dehydrogenase (LDH) and radiological imaging (Contrast Enhanced CT or FDG PET scan). Formalin-fixed paraffin embedded (FFPE) tissue was utilized for performing translocation (x;18) test by Break-Apart Fluorescent In-Situ Hybridization (FISH) assay for the SS18 and its partner genes (SSX1 and SSX2). Translocation positivity was not essential for enrolment if the diagnosis was confirmed by the sarcoma pathologists.The treatment consisted of 12 weeks of GD combination with gemcitabine 900 mg/mQuality of life (QoL) assessment was done by the 30-item questionnaire developed by European Organization for Research and Treatment of Cancer (EORTC)—the Core Quality of life Questionnaire (QLQ C30) [