Dissociation
ADVERSE EVENTS, EVENTS
Dissociation included reports of perceptual disturbances where sounds, visual stimuli, and proprioception seemed exaggerated or altered, or by a sense of derealization or depersonalization. Overall, dissociation was reported in 24.4% of participants. Although no treatment for dissociation was recommended or specified in the study protocol, a few participants (0.8%) received treatment with concomitant medication(s) for dissociation, which primarily (4 of 8 participants) consisted of single doses of a benzodiazepine anxiolytic (alprazolam, diazepam, lorazepam). There were no serious adverse events of dissociation.Almost all (5358/5369, 99.8%) adverse events of dissociation occurred and resolved on the day of dosing. Seven (0.6%) participants had 1 or more dissociation events that resolved after the day of dosing, all within 2 days after dosing. No participant had esketamine dose changed due to dissociation.