Efficacy assessments
Pain, fatigue, pain
REMISSION, DISEASE, DISEASE
RA disease activity was assessed using the CDAI, the Simple Disease Activity Index (SDAI), and the Disease Activity Score 28-CRP (DAS28-CRP), all of which have previously been validated for use in RA. CDAI is based on the sum of tender and swollen joint counts (TJC and SJC) of 28 joints, patient global assessment (PtGA) of disease activity measured on a visual analogue scale (VAS, range 0–100 mm), and physician global assessment (MDGA, VAS 0–100 mm) [PROs used in the study included measures of disease activity, physical function, pain, and fatigue. The Routine Assessment of Patient Index Data 3 (RAPID3) is a validated composite index of RA disease activity based on 3 PROs included in the American College of Rheumatology Core Set PRO components: Patient Physical Function/Disability, Patient Pain, and PtGA. Each domain is scored from 0 to 10, for a total score of 30 and disease activity categories include remission with a score ≤ 3, score > 3 and ≤ 6 for LDA, score > 6 and ≤ 12 indicative of moderate activity, and high activity defined by a score > 12 [