Introduction
In the last decades, public and private organisations tried to improve automobile safety and decrease unsafe driving practices by addressing impaired driving [Driving performance must be captured in a reliable, repeatable, and sensitive manner to study the effect of interventions (e.g., sleep deprivation, medication, or distractions in the car). Limiting the environmental variables (e.g., interaction with other road users) and standardising road conditions (e.g., length, number of lanes, or speed limit) supports the creation of a standardised test. Many on-the-road driving studies are performed on a highway where subjects stay in a single lane and thus limit their interactions with other drivers. While this standardised procedure results in reliable and repeatable results, one could argue that this costly and time-consuming measurement can be easily replaced with a driving simulator.Simulated driving is a widely used alternative for on-the-road driving. Besides cost-effectiveness, high levels of drugs and alcohol can be tested in a laboratory setting with medical assistance nearby. This makes the driving simulator an attractive and safer method to study healthcare interventions on driving behaviour. Moreover, in 2017, the United States Food and Drug Administration (FDA) started accepting driving simulator studies for the registration of (new) drugs in some conditions [Driving performance is often quantified by measuring a single measure describing the swaying/waving of the car and expressed with the standard deviation of the lateral position (SDLP). This measure is sensitive to CNS modulators (e.g., sleep deprivation, alcohol, and drugs [