References
Boxplots of Apolipoprotein D (ApoD) and Apolipoprotein E (ApoE) protein levels as a function of the instrumental activities of daily living (IADL) index. Comparisons were made for both dried blood samples (DBS) and plasma microsamples. The Y-axis corresponds to the z-scores obtained for each of the proteins. Mann–Whitney Generic workflow from plasma and DBS samples to LC-MS analysis. Generic representation of the sample preparation workflow before LC-MS analysis. After transferring to a 96-deep-well plate, multi-step sample preparations were performed on an AssayMap Bravo (Agilent Technologies, Lexington, KY, USA). A bottom-up approach was used to perform protein quantification by MS. To obtain optimal results, protein samples were extracted/denaturated/reduced and alkylated before the protein digestion with trypsin. Clean samples were then injected on the LC-MS instrument.Demographic and clinical characteristics of the population. Minimum, maximum and median values observed in the population were reported, as well as the 25th and 75th percentiles (25–75 P).Abbreviations: Instrumental Activities of Daily Living Scale (IADL), Body Mass Index (BMI), Mini-Mental State Examination (MMSE).Protein correlation of plasma microsampling and DBS. Significant 