Analysis of treatment effect on biomarker levels
For the evaluation of treatment effects (pharmacodynamic responses), changes in biomarker levels were compared between the active treatment and placebo groups. A contrast dataset for within-participant changes in biomarkers was generated from log2-transformed data, with the difference between the time point and baseline calculated for each participant and time point (Week 4, 16, 24, and 48). Differences were considered significant if they were  ≥ 1.4-fold with a 