Quantitative sensory testing
HPT, MPS, Neuropathy, pain
HEAT, COLD, NEUROPATHY
In quantitative sensory testing the control group showed a decrease by 45% in heat pain threshold, as a parameter assessing thermal pain (Z-score -0.76 ± 0.37 at baseline vs. -1.10 ± 0.30 after intervention; P=0.02), whereas no such change was observed in the FMD group (Z-score -0.02 ± 0.36 at baseline vs. -0.47 ± 0.41 after intervention; P=0.50). However, the difference did not change between study groups (P=0.55) (Neuropathy Assessment Composite z-Scores. Quantitative sensory testing (QST) parameters are plotted as composite z-scores: z-values of the single tests were clustered to: thermal detection (average values of CDT, WDT, and TSL, demonstrating thermoreceptive Aδ- and C-fiber function), thermal pain (average values of CPT and HPT, representing nociceptive C-fiber function), mechanical detection (average values of VDT and MDT, demonstrating tactile Aβ fiber function), and mechanical pain (average values of MPT, MPS, and PPT, representing nociceptive Aδ and C-fiber function). M-Diet, Mediterranean diet; FMD, fasting-mimicking diet, CDT, cold detection threshold; WDT, warm detection threshold; TSL, thermal sensory limen; CPT, cold pain threshold; HPT, heat pain threshold; PPT, pain pressure threshold; MPT, mechanical pain threshold; MPS, mechanical pain sensitivity; WUR, wind-up ratio; MDT, mechanical detection threshold; VDT, vibration detection threshold. ns, non-significant.