Phase 2: CBD safety clinical outcomes after application on normal oral mucosa
To assess the local and systemic side effects of CBD oral paste after applying it on healthy oral mucosa, 50 healthy subjects (25 males and 25 females, 18–65 years old) were recruited to participate in this study. The subjects were instructed to apply CBD over their lower labial mucosa with a provided calibrated spoon 3 times/day after meals for 7 d. Oral examination, vital signs, and blood tests were performed before and after CBD use. The blood parameters evaluated comprised glucose, hematocrit, sodium, potassium, chloride, total CO