3.3. Secondary Outcomes
diarrhea, constipation
Stool consistency: The numbers of patients with Bristol Stool Scale scores reflecting diarrhea, normal stool consistency, and constipation after 6 weeks treatment were 7 (16%), 34 (79%), and 2 (5%) with blueberry and 12 (28%), 24 (56%), and 7 (16%) with placebo treatment (Breath tests: The effects of blueberry and placebo treatments on the mean AUC of breath hydrogen and methane concentrations over the first 2 h after the fructose challenge were not significantly different (The effects of both treatments on the reported GI and CNS symptoms during the fructose breath tests were not significantly different and there were no significant carry-over or period effects (