Primary and Secondary Outcomes
Delirium, Confusion
Abbreviations: HR, hazard ratio; ICU, intensive care unit; OR, odds ratio; WBC, white blood cell count.SI conversion factors: To convert albumin to grams per liter, multiply by 10; blood lactate to millimoles per liter, multiply by 0.111; creatinine to micromoles per liter, multiply by 88.4; creatine kinase–MB fraction to micrograms per liter, multiply by 1; platelet count to ×10Maximum Confusion Assessment Method for the ICU score and mean laboratory values were calculated over the treatment period for each patent before applying statistical summaries.Delirium tested by logistic generalized linear mixed-effects model with random site effect. Other outcomes tested by the van Elteren test stratified by site.Mean differences are reported.ORs are reported.HRs are reported.