PKs
In Parts A + B, at day 7, an 8.6-fold increase in the mean predose concentration of tropifexor in plasma was observed for a 9.0-fold increase in dose. Similarly, for 2 h postdose mean concentrations there was an 11.5-fold increase in mean concentration for a 9.0-fold increase in dose. Mean predose concentrations showed minimal fluctuation over the study duration. In Part C, mean predose concentrations showed minimal fluctuation over the study duration. Mean postdose tropifexor concentrations were only slightly increased relative to mean predose concentrations (data not shown).