Introduction
cancer, sarcoma, fibrosarcoma
VIRUS, PROLIFERATION, CANCER, MUTANT, SARCOMA, FIBROSARCOMA
The epidermal growth factor family of trans-membrane receptors (ERBB family) members are effective mediators of normal cell growth and development [Neratinib, a potent oral, irreversible, pan-ERBB inhibitor targets EGFR, HER2, and HER4 at the intracellular tyrosine kinase domains [The MAPK pathway, the prominent downstream effector of ERBB signaling, is comprised of rat sarcoma virus (RAS), rapidly accelerated fibrosarcoma (RAF), mitogen-activated protein kinase kinase (MEK) and extracellular signal-regulated kinase (ERK). This pathway is involved in proliferation, survival and differentiation and as a result, deregulation of this pathway contributes to cancer [Additionally, the mutant RAS pathway amplifies the ERBB kinase activity both in vitro and in vivo [