2. Materials and Methods
2017–3228
RECRUITMENT
A factorial design was conducted for a cross-over randomized controlled trial. The recruitment of participants took place at the Centre Hospitalier Universitaire (CHU) de Québec-Université Laval Research Center between February 2017 and July 2018. A total of twenty-seven hyperinsulinemic adults (comprising 19 men and 8 women, with an average BMI of 31.3 ± 3.3 kg/mThese criteria included having fasting insulin levels above 90 pmol/L, fasting glucose levels below 7.0 mmol/L, and glycated hemoglobin (HbA1c) levels below 6.5%. The recruitment process involved using advertisements or email lists. The research received ethical approval from the ethics committee of the CHU de Québec-Université Laval Research Center (2017–3228 and 2022–6092) and was carried out following the ethical guidelines established in the Declaration of Helsinki. All patients were informed with comprehensive information regarding the trial’s objectives and procedures, and the participants were each provided with signed informed consent forms. Furthermore, the trial was officially registered on 