Reference standard
cancers
CANCERS
Two fellowship-trained radiologists (J. M. L. and J. H. K., with 20 and 4 years of experience, respectively, after fellowship) who did not participate in the review session reviewed the images to establish the reference standard for FLL detection. This reference standard was based on the most recent follow-up imaging, including a standard dose of liver CT or liver MRI taken within 3 months for patients with LR-3, -4, -5, or -M observations. For both groups, interval cancers identified during follow-up were considered true FLLs that had been missed on CECT. For those with no FLLs or only benign FLLs, remote cross-sectional images were used instead of 3-month follow-up images. A comprehensive description of the reference standard can be found in the supplementary material 