Eligibility and exclusion criteria
PD, bone loss, diabetes
CHRONIC INFLAMMATORY DISEASE, DISEASES, BONE LOSS, DIABETES
The inclusion criteria for subjects included presence of at least 18 scorable teeth (not including third molars), ≥ 4 teeth with PD ≥ 6 mm and CAL ≥ 5 mm, radiographic bone loss extending one-third of the root length, no periodontal treatment performed in the past. The exclusion criteria were as following: smoking, history of diabetes or chronic inflammatory disease, any diseases that compromise wound healing, history of radio- or chemotherapy, history of nonsteroidal anti-inflammatory drug (NSAIDs) intake > 3 days or use of antibiotics or corticosteroids 3 months prior to the study, a diet rich in omega-3 PUFAs or supplementation with omega-3 PUFAs.