INTRODUCTION
DRUG-DRUG INTERACTION
Tebipenem pivoxil hydrobromide (TBP-PI-HBr) is a novel prodrug of tebipenem (TBP), a carbapenem that undergoes rapid conversion to the active moiety TBP after oral administration. TBP exhibits broad spectrum In a Phase 1 single- and multiple-ascending dose study of TBP-PI-HBr, plasma concentrations of TBP increased in a linear and dose proportional manner, and the half-life of approximately 1 h was constant across a range of doses from 100 to 900 mg (A systematic review of potential drug-drug interactions with gastric acid-reducing medications found potentially clinically meaningful interactions only with some oral cephalosporins (