Conclusions
AKI, critically ill
CRITICALLY ILL, SEPTIC SHOCK
In conclusion, the ideal timing for RRT initiation in the setting of severe AKI, despite the publication of high quality randomized controlled trials on this topic, remains a complex and partially unanswered question. Early initiation of RRT is associated with higher mortality in patients whose AKI was diagnosed solely on the basis of elevated serum creatinine. Our study shows that among critically ill patients with septic shock, mortality following early or delayed initiation of RRT is different, depending on the criteria used to diagnose AKI. This highlights a need for further research into the clinical and biological markers of AKI severity, and the indications for RRT. Future studies should aim to identify predictive factors of the need of RRT, in order to better select populations included in future trials about the timing of RRT.