ADAMTS13 activity
ADAMTS13
ITTP, EVENT, RECURRENCE
Mean ± SE ADAMTS13 activity increased steadily from 7.06 ± 6.12% at screening to 39.37 ± 7.80% at the end of Week 1, then dropped to 28.18 ± 6.76% at Week 2 (1 week after the end of TPE), and increased again to 49.5 ± 10.15% by the Week 5 visit. The participant who had iTTP recurrence had an ADAMTS13 activity level of < 1% at the time of the recurrence. ADAMTS13 activity level at the end of treatment exceeded 10% in all participants. Twenty of 21 participants achieved a sustained ADAMTS13 level of ≥ 10%, which was defined as two consecutive weekly visits at which ADAMTS13 activity was ≥ 10%, and the median time to achievement was 13.68 (95% CI 5.95–24.76) days (25% quartile 5.95 [95% CI 4.44–6.92] days; 75% quartile 33.53 [95% CI 13.69–46.90] days; Fig. Kaplan–Meier curve of recovery of A disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) activity level to ≥ 10%. The x indicates a censored event