Randomization
Participants were randomly allocated(1:1) into the COMB arm or MET according to the computer-generated random numbers applying the block randomization method. In the COMB arm, metformin (850mg BID) was given orally to all patients who received metformin, and beinaglutide was given subcutaneously 5 minutes before a meal to all patients who received beinaglutide, starting at 0.1mg TID and increasing to 0.2mg TID two weeks later. After 12 weeks of treatment, the two groups were stopped and followed up for 4 weeks.