Statistical analyses
fasting TG, SAD
For serum ANGPTL3, lipid, lipoprotein and lipoprotein concentrations, the percentage change from baseline at post-baseline visits were analyzed using a linear mixed model repeated measures (MMRM) approach with fixed effects for treatment, week, treatment by week interaction, baseline value as a continuous covariate and baseline by treatment interaction. As a post hoc analysis, in cases when the statistical assumptions could not be satisfied, especially for the analysis of fasting TG, a non-parametric approach with the Hodges–Lehmann method was used. The sample size chosen for the study was selected without statistical justification but was considered adequate for assessing the study objectives.Not all interventions in the basket trial design were placebo controlled—for example, HPs in the MAD cohorts. Therefore, in an exploratory post hoc analysis, given similarities between the HP SAD and MAD cohorts, data pooled from the placebo groups in the SAD cohorts were used to compare with results from the MAD HPs.