Funding
This work was partially supported by the Institute of Health Carlos III (Spain) and co-funded by FEDER (PI15/01437), as well as the Spanish Ministerio de Ciencia, Innovación y Universidades, under the Programa Estatal de Investigación, Desarrollo e Innovación Orientada a los Retos de la Sociedad (Ref.: RTI2018-097290-B-C31).