Biomarkers
ovarian cancer, TNF‐α
OVARIAN CANCER, RECURRENCE
There were no significant differences between arms for any of the biomarkers at baseline with the exception of the exploratory biomarker TNF‐α with lower levels observed in the exercise arm (Baseline serum biomarkers.17.42 (14.79,20.04)
Effect of exercise versus attention‐control on baseline to 6‐month changes in prespecified and exploratory serum biomarkers.
The baseline, 6‐month and 6‐month change from baseline are least squared means and 95% confidence interval from linear mixed effects model analysis with baseline values, site, recurrence prior to baseline, chemotherapy at baseline, and two stratification factors for randomization (stage and age) held constant.Of the exploratory biomarker analyses, significant between‐group differences were observed for baseline to 6‐month changes for VEGF (exercise group 39.9 (12.3, 67.6) pg/mL; attention‐control −17.4 (−47.0, 12.3) pg/mL; between group difference When stratified by recurrence of ovarian cancer during the study, in the group who did not experience a recurrence, the exercise intervention effect for serum leptin was not significant (