Background
chronic disorder, OA, blood loss, pain, end-stage, knee arthroplasty, TKA, Knee osteoarthritis
CHRONIC DISORDER, KNEE OSTEOARTHRITIS, BLOOD LOSS
Knee osteoarthritis (KNEE OA) is a chronic disorder characterized by articular cartilage degeneration, which frequently results in deformity and pain in the knee joint of patients. Patients with end-stage KNEE OA will ultimately pursue knee arthroplasty as the only viable option. Yet, TKA can also trigger significant blood loss, in addition to its advantage of greatly improving the pain and function of patients, and blood loss is attributed to the release of surrounding soft tissues, multiple intraoperative osteotomies and synovectomy [Hemostatic materials are extensively utilized clinically in orthopedic surgery and are effective for perioperative hemostasis. At present, the clinical hemostatic materials for orthopedic surgery are mainly categorized into 3 types: bone wax, hemostasis-osteogenesis integrated materials, and biodegradable materials [Oxidized regenerated cellulose (ORC) is a type of biodegradable topical hemostatic material. In 1942, Yackel et al. first prepared oxidized cellulose and studied its property and characteristics [To this end, this prospective randomized control trial (RCT) was designed to analyze the effectiveness and safety of ORC in patients receiving TKA. We hypothesized that the use of ORC, a biodegradable local hemostatic material, is effective in diminishing perioperative blood loss, especially postoperative hidden blood loss, in patients receiving TKA, and also has a good safety profile.