Methods
The study was approved by the Research Ethics Board of The Hospital for Sick Children (SickKids), the Western Institutional Review Board and the Institutional Review Boards of each participating institution. For patient participation in the trial, informed written consent was obtained from participants and from the parents/legal guardians of minors (age specified by each institution). Patient outcomes will not be presented in this report. The trial was registered at clinicaltrials.gov (NCT04614662) on 04/11/2020. The methods relevant to this analysis consisted of the development of symptom management care pathway templates for 14 symptoms, adaptation of the care pathway templates at 10 institutions and a survey of institutional characteristics.