Main findings
fibroid
MINOR, SECONDARY, FIBROID, COMPLICATIONS
This multicenter RCT comparing PSA with GA for hysteroscopic myomectomy found similar percentages for completeness of fibroid resection in both groups (87.8% and 88.8%). However, significant noninferiority could not be demonstrated. Among secondary endpoint findings, hysteroscopic myomectomy appeared to lead to a considerable shorter hospital admission duration when performed under PSA. Immediately after surgery, women in the GA group reported a lower NRS score than women in the PSA group. However, at discharge and at 24 hours follow-up, NRS score was not significantly different anymore. No significant differences were found for other secondary outcomes. All complications that occurred were minor. Conversion from PSA to GA was not required.This is the first RCT comparing PSA with GA for hysteroscopic myomectomy. To our knowledge, there are no other trials that report on outcomes of PSA for hysteroscopic myomectomy alone. The largest prospective cohort study on PSA with propofol for therapeutic hysteroscopic procedures was performed by Cornelissen and colleagues, who described the results of 455 hysteroscopic procedures [