Translational analyses
tumor, MP
TUMOR, CYTOTOXICITY
Exploratory analyses aimed to evaluate peripheral and tumor profiles relating afami-cel, including its circulating persistence and pharmacodynamic immune markers, and the tumor microenvironment before infusion and after infusion. This included immunophenotyping and cytotoxicity of afami-cel manufactured product (MP), serum cytokine profiling and spatial protein and gene expression profiling of the tumor microenvironment.