Introduction
Colorectal Adenoma/Carcinoma, CRC) syndrome, MIM 120435, hereditary colorectal cancer, Lynch Syndrome, tumors
LYNCH SYNDROME, TUMORS
Lynch Syndrome (LS, MIM 120435), the most common hereditary colorectal cancer (CRC) syndrome, affects approximately one million people in the United States (Previous studies, such as the Colorectal Adenoma/Carcinoma Prevention Program-2 (CAPP-2) study found that the chronic use of aspirin, a non-steroidal anti-inflammatory drug (NSAID), had favorable efficacy as a chemoprevention for all LS-related tumors (At the time of publication of the original trial data, immune cell enrichment analysis based on mRNAseq data from normal colorectal mucosa using 