Author Contributions
C.B., P.M.H. and R.L. designed the clinical trial and conceived the investigations. E.N. conducted the clinical trial, participated in the planning of the current study, performed laboratory work, and performed the data analysis. E.N. interpreted the data and drafted the manuscript. J.D. was responsible for the generation of microbiota data, and E.P. performed bioinformatic processing of the microbiota data. C.B. has primary responsibility for the current paper. All authors have read and agreed to the published version of the manuscript.