Reactive CSF effusions persist up to 11 days after FUS treatment
frontal effusion, sulcal effusion, effusion, hyperintensity
EFFUSION, EFFUSIONS, EFFUSION
Interestingly, CSF effusions were additionally observed following FUS-mediated BBB opening in 8 of 8 subjects (100%). The effusions manifested on post-contrast T2-FLAIR sequences as sulcal and CSF space hyperintensity along the surface of FUS-targeted brain regions (Fig. The maximum effusion dimension varied from 1.2 to 5.3 cm in the eight participants. Effusion size in the frontal region averaged 1.6 cm on day 0 and 2.0 cm on day 1. Effusion size in the parietal region averaged 1.9 cm on day 0 and 2.6 cm on day 1. The temporal progression of effusions varied among individuals over 48 h following FUS treatment (Fig. Correlation of sulcal effusion size progression with FUS cavitation dose. Scatterplot shows progression of sulcal effusion size (fold change at 24 h) values trend with delivered mean cavitation dose. Orange, frontal effusion measurements; Blue, parietal effusion measurements