2.2. Anti-Glycation Activity of Peppermint Leaf Dry Extract and Its Polyphenolic Components
obesity, inflammation, hypertension
OBESITY, HYPERCHOLESTEROLEMIA, CARDIOVASCULAR DISEASE, HYPERLIPIDEMIA, HYPERTENSION, INFLAMMATION, IMPAIRED GLUCOSE TOLERANCE, DISORDERS, HYPERGLYCEMIA, INSULIN RESISTANCE, ADIPOSITY, METABOLIC SYNDROME, OXIDATIVE STRESS, TYPE 2 DIABETES
Excessive consumption of simple sugars, glucose and fructose, is one of the reasons for the epidemic of obesity, type 2 diabetes, metabolic syndrome, and cardiovascular disease. Non-enzymatic and enzymatic oxidation of monosaccharides leads to excessive production of RCS, carbonyl stress and related oxidative stress. The consequence is inflammation and malfunction of many tissues and organs, including the liver, kidneys, blood vessels and nervous tissue. These disorders mutually reinforce each other and the accompanying pathologies accumulate with increasing age, which is associated with the progression of cardiometabolic factors such as insulin resistance, impaired glucose tolerance, hyperglycemia, hyperlipidemia, hypercholesterolemia, hypertension and central adiposity [Along with HSA, BSA is the most commonly used in model studies of compounds with antiglycation, anti-AGE and anti-RCS potential. ICThe anti-AGE effect of polyphenols is related to their protective action against chemical modifications of substrates involved in the glycation reaction, such as binding to groups involved in the initiation of glycation or inhibiting the oxidation of simple sugars and ketoamines (Amadori products). A key component of this effect is the ability to capture glycation- or oxidation-initiating factors (RCS, ROS) [