Outcomes
death, Chronic Illness, overdose, fatigue
ADVERSE EVENTS, BLEEDING REQUIRING TRANSFUSION, CHRONIC ILLNESS
The coprimary outcomes were change in fatigue, as measured using the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F)Prespecified serious adverse events (SAEs) included death, hospitalization or emergency department visit, bleeding requiring transfusion or hospitalization, medication overdose requiring an emergency department visit or hospitalization, and acute suicidal intent. The relatedness of adverse events and SAEs with study interventions, especially with medications prescribed for symptom management, was reviewed by study nephrologists and an external adverse events committee. Lastly, patient satisfaction surveys completed anonymously were collected at end of study participation.