Validation of study paradigm
ADVERSE EVENTS
The details of participant flow from enrollment through analysis are detailed in Supplementary Fig. To avoid the confounding effects of over- or underfeeding on host and microbial metabolism, we evaluated energy balance by real-time assessment of energy intake (personalized to the energy needs of each participantSurveillance of adverse events revealed minimal gastrointestinal or other side effects that did not differ by diet (Supplementary Data 