Conclusions
depression, anxiety, cognitive defusion
This study was the first to investigate the effects of web- and mobile-based ACT interventions on nurses’ anxiety and depression symptoms by using an RCT with a large sample size. Our findings are promising, demonstrating the effectiveness of the intervention on nurses’ health outcomes and providing new ideas for hospital administrators to prevent and intervene in nurses’ psychological issues. In addition, we comprehensively explored the psychological mechanism of web- and mobile-based ACT interventions and found that psychological flexibility, cognitive defusion, and values are the key mediating variables. This finding supports the We acknowledge the participants of our study.This study was funded by the Surface Project of the National Natural Science Foundation of China (grant 32071084) and the Fundamental Research Funds for the Central Universities (grant 2022JC016).Authors' Contributions: Y Lu and YH contributed to investigation and data curation. Y Lu contributed to the conceptualization, formal analysis, and writing of the original draft. Y Li, YH, XZ, JW, and LW contributed to the methodology, writing, reviewing, and editing. FC contributed to funding acquisition, resources, supervision, validation, writing the review, and editing. All authors approved the final draft of the manuscript.Conflicts of Interest: None declared.Web- and mobile-based acceptance and commitment therapy intervention program for anxiety and depression symptoms in nurses.Screenshot of the Rain Classroom WeChat mini program.Effects of the web- and mobile-based acceptance and commitment therapy intervention based on complete case data.Comparison of baseline general information for completed and missed samples.CONSORT-eHEALTH checklist (V 1.6.1).