Estimand strategies for handling intercurrent events
EVENTS
In line with the new In short, in case of treatment failures (comprising all intercurrent events that required additional injections of corticosteroid into the index shoulder or surgery of the index shoulder that were definitely, probably or possibly related to the study treatments, including development of a full-thickness rotator cuff tear) subjects' data were handled using a combination of the While-on-Treatment StrategyIn contrast, intercurrent events that required additional injections of corticosteroid into the index shoulder or surgery of the index shoulder that were unlikely related or unrelated to the study treatments (e.g., accidents that affected the index shoulder) were handled using a combination of the While-on-Treatment Strategy and a Hyopthetical StrategyIn line with recommendations in the literature