Study participants
septic shock
SEPTIC SHOCK, SEVERE SEPSIS
Among 3195 patients from the JSEPTIC-DIC study cohort, we identified 1911 patients with severe sepsis or septic shock who were admitted 34 ICUs where PMX-HA was available. High prevalence of patients on renal replacement therapy (RRT) among those subsequently treated with PMX-HA was reported by previous studies possibly because of easier access to extracorporeal circulation [Among 450 patients from the EUPHRATES trial cohort, we identified 286 patients treated with the standard regimen of PMX-HA treatments or standard of care without PMX-HA who had complete data available for Acute Physiology And Chronic Health Evaluation II (APACHE II) score, Sequential Organ Failure Assessment (SOFA) score, white blood cell (WBC) count, platelet count, prothrombin time-international normalized ratio (PT-INR), and blood lactate concentration.We used the JSEPTIC-DIC study cohort as a derivation cohort to identify targeted subpopulations of PMX-HA and EUPHRATES trial cohort as a validation cohort to verify the derived criteria, respectively (Fig. 