Missing data and intent-to-treat
REGRESSION, EVENT
In the event of missing data, we will examine the data to determine if omission varies by study arm. However, our approach using mixed effects regression modeling will provide accurate estimates and inference in the presence of missing data under certain assumptions. We will check these assumptions and, if necessary, perform sensitivity analyses to quantify the effect of missing outcome data on our results. All outcomes will be analyzed on an intention-to-treat basis.