Recruitment, randomisation, and withdrawal
throat, Anxiety
Between July 30, 2019 and November 9, 2022, 110 participants were randomised across 17 centres; 55 to receive melatonin and 55 to receive midazolam (CONSORT flow diagram. mYPAS-SF, modified Yale Preoperative Anxiety Scale-Short Form; PI, principal investigator; RN, research nurse.Baseline characteristics of randomised participants. Select percentages may not sum to 100 because of rounding. Assessed numbers are given where data were not available for the whole population. ENT, ear, nose, and throat; IQR, inter-quartile range; mYPAS-SF, modified Yale Preoperative Anxiety Scale-Short Form; STAI, State Trait Anxiety Inventory.Boxplots of mYPAS-SF scores at each time point by treatment group. mYPAS-SF, modified Yale Preoperative Anxiety Scale-Short Form.