Liver histology
NASH, fibrosis, steatohepatitis
FIBROSIS, STEATOHEPATITIS
At least a 1-point improvement in fibrosis stage was observed in 32.3% (10/31), 31.6% (12/38), 29.7% (11/37), and 32.5% (13/40) of patients in the TXRParticipants’ histological response at week 48 in all groups based on NASH CRN staging. (A) Proportion of patients with change in fibrosis stage and (B) proportion of patients with steatohepatitis resolution. Abbreviations: CRN, clinical research network; CVC, cenicriviroc; TXRThe proportion of patients with paired biopsy results at week 48 with at least 2-point improvement in fibrosis (NASH CRN staging) regardless of steatohepatitis status or without worsening of steatohepatitis at 48 weeks of treatment was considered not to be clinically meaningful (Supplemental Table S2, At week 48, no consistent changes in liver collagen morphometry were observed in combination treatment groups, with the highest response in the TXR