Thalamic MRS measures of brain injury and Bayley Scales of Infant Development-III (BSID-III) outcomes.
death, NDI, brain injury
BSID-III 10 A global pattern of brain injury was the neuroimaging finding with the highest positive predictive value and highest specificity for predicting adverse 2-year outcomes, with all 34 affected infants either dying or developing severe NDI. The presence of any injury on MRI (i.e., global injury score > 0) had the highest sensitivity (0.83) for predicting the dichotomous outcome of death or NDI, while a lactate/NAA ratio in the top quartile in the thalamus (0.14 to 7.59) or peripheral white matter (0.27 to 5.13) demonstrated the highest specificity (0.87 and 0.81, respectively) for death or NDI (Fig. 