Authors’ contributions
RA, MM
LY, BA, JH, MC, JDD, JM, JS and PM contributed to the design of the trial. LY, BA, JH, MC, PM, JDD, FdV, ME, PC, RD, JM, JS, SM, BS, PL, SW, RA, NF, KM, CR, LT, MW and MM were members of the project team and contributed to trial conduct interpretation of the study findings. HJC, CB, AM, SB, BG and the OpenSAFELY Collaborative supported data management, linkage and extraction within the OpenSAFELY platform. BA, SM, JDD, FdV and SW analysed the data collected during the study. All authors contributed to editing of the manuscript. The authors read and approved the final manuscript.