Study design and patient selection
psychiatric illness, denosumab/bisphosphonates, diabetes
HEART DISEASES, PERIODONTAL DISEASE, PATHOLOGY, BLEEDING DISORDERS, DIABETES
This study was design as single-center, double-blind RCT to study the influence of surgical technique on PS in different bone types. This trial was conducted in patients undergoing the placement of dental implants in maxillary second premolars and molars sites at the Clinic of the School of Dentistry of the University of Granada (Spain) between January 2021 and March 2022.All participants received a detailed description of the study protocol and signed informed consent to participate in the study, which followed the guidelines of the Helsinki Declaration and was approved by the ethics committee (n° 2324/CEIH/2021) of the University of Granada. This clinical trial was registered in the Australian New Zealand Clinical Trials Registry (ACTRN12622001311741) and follows the recommendations of the CONSORT 2010 statement for reporting randomized trials [Study inclusion criteria were as follows: age ≥18 years, ASA I–II status according to the American Society of Anesthesiologists, edentulism in the maxillary second premolar or molar region, smokers of less than 10 cigarettes/day, periodontally healthy or controlled periodontal disease, and patients who sign the consent to participate in the study. The exclusion criteria were as follows: age under 18 years, pregnancy or breast-feeding, ASA III, IV, or V status (diabetes uncontrolled, heart diseases, bleeding disorders, compromised immune system), previous or active treatment with antiresorptive drugs (denosumab/bisphosphonates), use of illicit drugs, irradiated patients, severe psychiatric illness, and poor oral hygiene or untreated periodontal pathology.