Trial design
fatigue
This superiority RCT followed after a non-inferiority RCT, in which patients received either face-to-face or blended CBT. Blended CBT was non-inferior to face-to-face CBT with respect to its positive effect on fatigue severity.Consort flow diagram.*Non-inferiority RCT (RCT1).Only participants who adhered to the initial treatment period of 20 weeks were included in the booster trial. Adherence was defined as (a) having started treatment and (b) having finished the initial treatment period with a face-to-face session and assessment at T20.