Exclusion Criteria
ocular dryness
OCULAR INFECTION
Participants were excluded if they had worn contact lenses within 30 days before the study, had history of refractive surgery or any recent ocular surgery, ocular infection, or contraindications to high-dose omega-3 supplementation such as anticoagulant therapy. Patients regularly using treatments for DED, including omega-3 fatty acid oral supplements (eicosapentaenoic acid and docosahexaenoic acid <1200 mg by mouth daily), systemic medications associated with ocular dryness, systemic corticosteroids, or other immunosuppressive agents were permitted to continue these treatments if committed to using them for 12 months. Patients were excluded if they used <90% of run-in supplements (placebo soft gel capsules) on the days between the screening and randomization visits.