Introduction
hemolysis, sickle cell disease, PD
DISEASE, HEMOLYSIS, ADHESION, SICKLE CELL DISEASE
P-selectin is a cell adhesion molecule expressed by platelets and endothelial cells [In sickle cell disease (SCD), polymerization of sickle hemoglobin leads to rigid, sticky, sickled red blood cells (RBCs) that are prone to hemolysis, creating a procoagulant and proinflammatory environment that contributes to vaso-occlusive crises (VOCs), one of the clinical hallmarks of the disease [Inclacumab is an investigational mAb that is also directed against human P-selectin [Here, we report results from a phase 1, open-label, single-ascending-dose study of inclacumab designed to characterize the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and immunogenicity of inclacumab at doses up to and exceeding those previously evaluated in healthy individuals.