Introduction
malaria, malaria infections
MALARIA, REGRESSION, DISEASES
Pregnancy greatly changes the physiology of a woman and increases vulnerability to diseases such as malaria by lowering the immune system [Mothers from malaria endemic areas pass on immune IgG to their children [A study in Papua New Guinea randomized mothers into two groups of Sulfadoxine- Pyrimethamine-Azithromycin and SP-chloroquine as malaria prophylaxes and found no difference in cord antibody levels (total IgG) between the two groups [In this study, we determined if use of either DP or SP prophylaxis has any effects on cord levels of IgG. We further examined if placental malaria has any effect on expression of IgG in cord blood. Using cox regression, we modelled if cord blood levels of total IgG against Rh4.2, PfSEA, Etramp5Ag1, AMA1, EBA175 and GLURP181 adjusted for maternal wealth category index, gestational malaria prevalence, gravidity and birth weight have any effects on the risk of malaria infections in the first birth year.