Secondary outcomes
renal damage, RIFLE, VFDs
REGRESSION, EVENT, END STAGE RENAL DISEASE, SECONDARY
We used zero-inflated negative binomial (or zero-inflated Poisson) mixed models to assess the effect of exposure to the POINCARE-2 strategy on the cumulative number of MVFDs and VFDs. Logistic regression models adjusted for potential confounders were computed to examine the effect of the strategy on the occurrence of at least one unexpected harmful event or renal damage. We conducted all secondary analyses on complete cases only. We excluded from the RRTFDs analysis patients who were already at the worst stage of the RIFLE classification (i.e., “end stage renal disease”) at Day2.We used SAS 9.4 (SAS Institute, Inc) and R v4.0.3, with a level of significance set at 0.05.