Statistics
For statistical calculations, we used SigmaStat/SPSS (Systat Software Inc., San Jose, CA, USA) software. Descriptive statistics were calculated for all variables of interest. Means and standard deviations were calculated for continuous outcomes. Frequency and percentage were calculated for categorical outcomes. The Fisher exact test was used to compare frequencies. Student’s t-test was used to compare the mean values between the two groups. Paired t-test was used to compare paired data, which was obtained at baseline and six weeks. Wilcoxon signed rank test was used to compare the VTI data. The study has adequate power to detect a difference after 32 patients’ enrollment. Power analysis was performed [G*Power Statistical Power Analyses Software [