(ROI) delineated
amnestic, aMCI, cognitive impairment
The ROIs were manually delineated on the horizontal T1 images for segmentation using the ITK‐SNAP software (Version 3.6.0, Wikodeling for aMCI patients. (a) Drawing ROIs in frontal lobe using ITK‐SNAP. (b) Strategy for frontal lobe extraction from high‐resolution structural MRI. (c) Intensity features and textural features were extracted from the images, and used the LASSO to choose the optimized subset of features to construct the final model. (d) Statistical analysis was used to find radiomic features. aMCI, amnestic mild cognitive impairment; LASSO, least absolute shrinkage and selection operator; MRI, magnetic resonance imaging; ROIs, regions of interest.ROI delineation criteria are as follows: (i) the circular measurement tool was used to delineate the ten consecutive layers in the white matter of frontal lobe; (ii) the size of the bilateral ROI of all subjects remained the same, with an area of about 10 mmOne of the above‐mentioned radiologists randomly selected and drew 50 cases independently. After 1 month, radiologist A repeated the same procedure again. An intra‐class correlation coefficient (ICC) greater than 0.75 is considered to indicate good consistency. In our study, we obtained a good ICC result (see Results section for details).