IgG antibodies to PfCSP.
Serum antibody responses to PfCSP by ELISA for individual participants 2 weeks after the third immunization and ratios of post-immunization (post) to pre-immunization (pre) values are presented in Net OD 1.0 IgG antibodies to PfCSP by ELISA 14 days after the third immunization with PfSPZ Vaccine or normal saline, by group. Horizontal arms represent medians and are bracketed by the interquartile range. Each point represents the results for a unique participant. Filled circles (⬤) represent participants not infected after CHMI; open circles (○) represent participants who were infected after CHMI (ages 18–35 years only).To compare antibody responses to PfCSP between age groups, the ANOVA on rank test was performed separately for net OD 1.0 and OD 1.0 ratio (fold-change from baseline). The differences in mean antibody response levels between the groups for both net OD 1.0 and OD 1.0 ratio 2 weeks after third vaccination were highly significant (Comparison of Net OD 1.0 anti–PfCSP antibody levels in infants and children with levels in 18–35-year-old adults protected against Using age 11 years as an approximation to distinguish the effects of pre- and postpubertal differences between male and female participants, no difference was detected in median antibody levels between male (OD 1.0 of 13,518, 