Introduction
hypoparathyroidism, endocrine disease, Hypoparathyroidism
HYPOCALCEMIA, HYPOPARATHYROIDISM, ENDOCRINE DISEASE, HYPOPARATHYROIDISM
Hypoparathyroidism is an endocrine disease caused by insufficient or absent production of parathyroid hormone (PTH) with multiorgan involvement. Under normal physiological conditions, PTH and its downstream hormone calcitriol are the primary regulators of calcium and phosphate and act on the bone, kidney, and intestine.Current consensus guidelines for the long‐term management of chronic hypoparathyroidism have identified six therapeutic goals: (i) prevent signs and symptoms of hypocalcemia; (ii) maintain the serum calcium concentration within or slightly below the normal range; (iii) maintain the calcium × phosphate product below 55 mgPTH replacement therapy is the ideal physiologic treatment for hypoparathyroidism.TransCon PTH (palopegteriparatide) is an investigational once‐daily prodrug with sustained release of active PTH in development as a treatment for adults with hypoparathyroidism.