Endpoints
ADVERSE EVENTS, ADVERSE EVENT
The primary endpoint was the percent change from baseline to week 12 in LDL-C levels. Secondary endpoints included proportion of participants achieving ≥50% LDL-C reductions and proportion of participants with LDL-C <1.8 mmol/L at week 12 and 24, the change from baseline to week 12 in non-HDL-C, apolipoprotein B and lipoprotein(a) levels, as well as the change from baseline to week 24 in lipid levels.Safety endpoints were assessed by adverse events, vital signs, electrocardiogram, and laboratory measurements. Adverse events were coded and classified using Medical Dictionary of Regulatory Activities (MedDRA, version 24.0). The severity and causality of adverse events were assessed by investigators based on pre-specified criteria. Immunogenicity was assessed by detecting anti-drug antibodies and neutralizing antibodies.