Prophylaxis
febrile neutropenia
-11, FEBRILE NEUTROPENIA
Anti-fungal agents were concomitantly used in eight patients, mostly as a prophylactic for patients with an absolute neutrophil count <500/μl; namely, fluconazole was used in four patients and voriconazole, micafungin, caspofungin was used for one patient each as antifungal prophylaxis. Dose modification for venetoclax was defined in the protocol when moderate and strong CYP3A inhibitors such as azoles were concomitantly administered. Granulocyte-colony stimulating factor (G-CSF) was used in five patients during venetoclax treatment, and two of them used it during febrile neutropenia (Concomitant use of G-CSF and neutrophil counts. (A–C) Time courses of neutrophil counts in Pt-10, -11 and -14 who received prophylactic G-CSF. (D, E) Pt-01 and -09 received G-CSF as treatment for febrile neutropenia. G-CSF, granulocyte-colony stimulating factor; Peg, pegfilgrastim; FN, febrile neutropenia; PRN, pro re nata; QD, quaque die (once a day or daily); VEN, venetoclax; Pt, patient; Scr, screening.