Randomization and masking
rupture
All eligible patient allocations were randomized at a 1:1 ratio based on an interactive Web response system. Information technology specialists developed the system from an independent clinical research organization. The online central randomization method ensured that the allocation was concealed. In addition, minimization criteria were applied to balance possible factors, including neck width, diameter length, location, and rupture status. Masking the treatment allocation to the investigators was not possible. However, members who followed up with trial subjects were blinded to the assignment.