Limitations
depressive disorder, migraine, pain
MIGRAINE, DISEASES
Our study has some limitations. First, the subjects in the current research were healthy people, but the application of EAS is aimed at patients with different diseases, and the current study is a small sample size study. Therefore, in the future, studies with a large sample size should be conducted with target groups of patients with certain diseases (depressive disorder, migraine, etc.). Second, for the group with real EAS, the needles were inserted into the skin and adjusted until the subjects experienced the deqi sensation. This process itself usually induces some degree of immediate pain due to the operation of twisting needles and the body's biochemical response to tissue damage. For sham EAS, in addition to producing the same psychological placebo effect, sham acupuncture needles produced a certain somatosensory touch that produced a stinging sensation at the same acupoints without penetrating through the skin. These two types of tactile stimulation might also produce a little different brain response, and Group 1 adopts non‐current stimulation, which increases the limitations of this study. In future, it is necessary to study the effect of current stimulation on the non‐acupoint group. Third, the scan time for the fMRI was 3 min and 30 s, and the MRI system was 1.5 T. These factors reduced the power to find changes in brain FC after EAS, so the signal‐to‐noise ratio is relatively low. To get more positive results, a lenient 