Analysis of correlations between RSN-FC and single voxel MRS metabolites
To explore possible interactions between neurochemical brain balance and RSN-FC, we also investigated associations of FC alterations between conditions with the respective changes of metabolite signals measured by single voxel sv-MRS analysis. The change in metabolite spectral signals across experimental conditions was calculated subtracting the metabolite signlas of the GHB condition from signals of placebo condition (e.g. [ΔGABA] = [GABA at placebo condition] – [GABA at GHB condition]).For internetwork connectivity, the change of correlation-