Study treatments and procedures
Tecan
The cohort dosing schedule is presented in Supplementary Table The Friedewald calculation was used for LDL-C measurements, unless TGs were >400 mg dlANGPTL3 was measured in serum sample sets batched by participant using an ELISA (R&D Systems) read for absorbance on a Tecan Sunrise reader.MRI-PDFF imaging sites used a 3T (preferred) or 1.5T (acceptable) MR system with appropriate abdominal coils to perform imaging of the liver, including T2 coronal liver, T2 axial liver and multi-echo fat quantification as per the image acquisition manual. Images were centrally read and reported by Medpace Core Labs. Lipid and lipoprotein results were reported by Medpace Research Laboratories. All other parameters were reported by Sonic Clinical Trials.