Distribution of CP and PoS, and calibration of a cutoff
RECRUITMENT
For the investigated simulation settings, the CP, as well as the PoS, tended toward small values in case the null hypothesis was true, and toward large values when the alternative hypothesis was true (scenario 1 shown in To define the cutoff for stopping for futility for each method, we assessed the distributions of PoS and CP for the scenario that the assumptions of Kunz’s design were correct and patient recruitment per month was Poisson distributed with mean 