VAS and SNOT-22 assessments
pain, throat, nasal obstruction
DISEASE
Patients completed six individual VAS assessments daily (nasal obstruction, nasal discharge, mucus in the throat, loss of sense of smell, facial pain, and overall symptoms) using an electronic diary (eDiary) and a recall period of 24 h. For each VAS, patients rated their symptom on a scale from ‘none’ (0) to ‘as bad as you can imagine’ (100). Results were transformed linearly to a 0–10 range for reporting (higher scores indicated greater symptom severity); the psychometric properties were unaffected by this transformation.Patients also completed SNOT-22 assessments every 4 weeks using the same electronic device and a recall period of 2 weeks. A total of 22 symptoms were rated on a 0–5 scale, with a final total score of 0–110 (higher scores indicated greater disease impact on HRQoL). Endpoints from SYNAPSE relevant to this analysis are listed in Additional file 