PATIENTS AND METHODS
hand dermatitis, dermatitis, itching
ALLERGY, HAND DERMATITIS, MAY, SKIN REDNESS, CONTACT DERMATITIS, DERMATITIS
We performed a double-center randomized trial that enrolled workers with hand dermatitis. All workers received personalized training. The intervention was 3 times per day application of the study emollient. The control arm used an emollient of choice without ceramide, as needed. The primary outcome was improvement in hand dermatitis at 1 and 3 months of follow-up.Workers diagnosed with hand dermatitis (itching and burning of the skin with skin redness) at the Allergy Unit of the Occupational Medicine Division at the University of Trieste and University of Padua from January 2016 to May 2021 were asked to participate in the study. The inclusion criteria were contact dermatitis of the hand and agreement to participate in the study; the exclusion criteria were dermatitis that involved other body sites and chronic therapy with immunosuppressant drugs that could interfere with the outcome. Patch test was performed according to patients' compliance following our previous study protocol.All received personalized training with the aim of increasing their awareness of the importance of the adoption of preventive behaviors (regular use of emollients) and of the risk arising from skin exposure to irritants and strong detergents, drawn up on the basis of experiences described in the literature.After training, patients were randomly allocated using a series of causal numbers generated by a computer into 2 groups: 1 treated with a CC and 1 treated with a traditional emollient without ceramides 3 times a day (T0). CC is characterized by the 311Patients were invited to undergo a second and third clinical evaluation after 1 month (T1) and 3 months (T2). During the 3 clinical examinations, the TEWL was recorded to evaluate the skin barrier function.All participants provided written informed consent and the procedure was approved by the ethics committee of the Friuli Venezia Giulia region (CEUR 04-2017 on July 28, 2017).