Effect of treatment on biomarker levels
PsA
In participants randomized to guselkumab, reductions from baseline in levels of the Th17 effector cytokines IL-17A, IL-17F, and IL-22 and the acute phase proteins IL-6, CRP, and SAA were observed, while changes from baseline were not apparent in those who received placebo (Fig. Serum levels of IL-17A, IL-17F, IL-22, CRP, SAA, and IL-6 in participants with TNFi-IR PsA from COSMOS compared with healthy controls over time. Participants randomized to placebo crossed over to guselkumab at Week 16 (early escape; dotted line; 