Discussion
hypoalbuminemia, Edema, cancer
HYPOALBUMINEMIA, PROLIFERATION, CANCER, EDEMA, SECONDARY, METASTASES
Dysregulation of the HGF/c-Met signaling pathway can lead to aberrant cell proliferation, drug resistance, and promotion of cell migration and invasion.Edema and hypoalbuminemia are known side effects of HGF/c-Met inhibitors, including ficlatuzumab.With respect to the secondary objectives, this study showed that the addition of ficlatuzumab to the combination of gemcitabine and c-Met pathway activation has been associated with cancer cell proliferation and metastases,