Randomization and masking
CRF
CRF
Participants were randomly assigned to receive either adjunctive Aggrenox treatment along with standard of care (SOC) (Aggrenox group) or SOC (control group) alone in a 1:1 ratio using random permuted blocks. The randomization sequence was concealed from study staff and was integrated into the REDCap electronic data capture system built to record the study’s patient data by the study biostatistician. Patients were assessed daily while hospitalized and outcomes were examined through days 14, 28, and/or discharge. A COVID-19 baseline electronic case report form (eCRF; as available on the WHO website for COVID-related studies) was completed at admission and the daily core CRF were completed on subsequent days for the duration of hospitalization. Patients and health care providers were not masked to study group assignment.