AUD, stress proteins, immune cells, and electroencephalography (EEG) changes
Brain injury, sleep disorders, anxiety
RECURRENCE, BRAIN
Prolonged alcohol use significantly decreases leukocyte levels and antibody production. In case of long-term alcohol misuse, alcohol directly acts on tissues involved in stress response, which increases the production of stress-related proteins [In addition to biomarkers, changes in EEG are also important for AUD patients. Brain injury caused by chronic alcohol consumption involves deteriorated brain signaling, physiological and psychological tension through stimulation of the autonomic nervous system, and withdrawal symptoms such as anxiety and sleep disorders [Previous QEEG studies on patients with AUD have primarily focused on the patients’ states rather than post-treatment changes, Moreover, no studies have conducted QEEG before and after an AUD intervention program to observe changes. Brain wave analysis is clinically significant since brain waves are strongly associated with AUD severity and recurrence [