Intervention
The first group received a placebo capsule administered one hour before the surgical procedure along with 4 mg (2 ml) of ondansetron intravenously after anesthesia induction. The second group was given 80 mg aprepitant capsules one hour before the surgery, followed by an injection of 2 ml intravenous distilled water after anesthesia induction.All patients undergo Lefort I maxillary advancement osteotomy and Bilateral Sagittal Split Osteotomy mandibular setback surgery with the Dalpont method. Fixation of the maxilla was done by 4 L-shaped plates with 4 holes and fixation of the mandible by 3 screws.The anesthesia method of all patients was similar. Firstly, initial standard monitoring including non-invasive blood pressure (NIBP), heart rate (HR), electrocardiogram (ECG), end-tidal-CO