Intranetwork and internetwork functional connectivity modulate the therapeutic effect of rTMS
AD
DYSFUNCTION
Functional changes related to the therapeutic effect of rTMS at the level of brain networks remain relatively poorly understood. In this part of the study, we are aimed to characterize the underlying mechanism of cognitive improvement after rTMS treatment from the perspective of whole‐brain functional networks. We found that the positive network related to improved cognition was characterized by internetwork connectivity between DMN and DAN, while the negative network was involved in intranetwork connectivity within the DMN. Specifically, the DMN, primarily supporting internally directed cognition, is engaged in the resting state, whereas the DAN, involved in external attention, typically shows increased activity during external attention‐demanding processing.Among the large‐scale networks, the DMN was one of the first to be documented as a key network exhibiting dysfunction in AD, which is involved in internally directed and self‐referential cognition.