Background
tumor
TUMOR
Arginine methylation is an important posttranslational modification of proteins involved in diverse cellular processes such as gene regulation, ribonucleic acid (RNA) processing, mRNA splicing, deoxyribonucleic acid (DNA) repair, and signal transduction [GSK3368715 is a potent, reversible, S-adenosylmethionine (SAM)-uncompetitive inhibitor that binds to the protein substrate binding pocket of type I PRMTs. Inhibition of type I PRMTs reduces intracellular ADMA and leads to accumulation of MMA and SDMA [Genetic loss of the With or without MTAP loss, overexpression of PRMTs may represent a targetable vulnerability in many tumor types [