Pharmacodynamics and Immunogenicity
Total B-cell depletion (CD20 + B-cell level > 0 at baseline and 0 post baseline) occurred in three patients with baseline B cell counts of 20.0, 2.1 and 0.5, respectively.The T-cell activity assessment was not performed due to the termination of the AFM11 clinical programme. No cytokine results were reported. No ADA results were reported, so immunogenicity could not be determined.