Discussion
pain
RECURRENCE, BREAST CANCER, ADVERSE EVENTS, PCM, PATHOGENESIS
With the increasing amount of biomedical data, the traditional drug discovery campaign has been revolutionized with the aid of artificial intelligence techniques to accelerate the process and reduce the cost (Although the pathogenesis of PCM remains largely unclear, there have been numerous reports implicating that the overactivation of immunoinflammatory pathways plays an important role in the development of PCM (We want to remind the reader that a third arm (a placebo group) added to the clinical study might be useful to fully reveal the therapeutic effects of the herbal drug combination. Unfortunately, we were unable to add a third arm due to some ethical concerns. This is because PCM is a rather acute, severe, and intense clinical manifestation of breast. Without any treatment, the serious inflammatory condition of PCM may quickly advance into breast cancer. Therefore, this is a limitation of our clinical study, and we hope to design more delicate clinical trials in the future to demonstrate the therapeutic effects of herbal drug combination. Nevertheless, the detailed analysis of three indicators, including symptom score, pain score, and score of life quality, between the EG treated with herbal drug combination and the CG treated with methylprednisolone in the clinical study suggests that the herbal drug combination might be more effective in reversing the clinical conditions of PCM compared to the methylprednisolone treatment (see In this study, our results revealed that the herbal drug combination identified by knowledge graph could suppress a few key immunoinflammatory cytokines, enhance the systematic immune levels, and significantly reduce the recurrence rates of PCM patients. Note that recurrence has become one major obstacle after surgical resection for PCM treatment in clinical practice. On the other hand, hormone therapy may increase the risk of side effects for PCM patients. Therefore, our approach of herbal drug combination may provide a new avenue for PCM treatment with less recurrence rate and reduced incidence rate of adverse events.