Ethics
The study was approved by the Regional Danish Committee on Health Research Ethics (Regional Videnskabsetisk Komité)—approval no. H-18044908 and the Danish Data Protection Agency—approval no. VD-2018-453. The study was conducted in accordance with the declaration of Helsinki. The limited size of the study was solely based on the sample size calculation as it is, due to ethical considerations, recommended to avoid exposing more patients to trial examinations than what has been shown to be necessary to reach a conclusion.