Conclusions
heart failure, type 2 diabetes mellitus
HEART FAILURE, TYPE 2 DIABETES MELLITUS
The results of the present EmDia trial demonstrated that empagliflozin 10 mg/day improved diastolic function in patients with type 2 diabetes mellitus and elevated left ventricular end-diastolic pressure within 12 weeks of treatment. The beneficial effect of empagliflozin was consistent across all subgroups and also occurred in subjects with heart failure and preserved ejection fraction, supporting the positive effect of empagliflozin reported in the literature regarding the treatment of patients with heart failure and including patients with heart failure with preserved ejection fraction. Because the identified positive hemodynamic, metabolic, and hematological effects of empagliflozin explain only part of its effect on cardiac function, future studies will be important to identify to what extent this mechanism contributes to improved clinical outcome in subjects with heart failure.