Findings in context
type 2 diabetes of actually upgraded adherence, diabetes
TYPE 2 DIABETES, DIABETES
A robust and strong protective effect against type 2 diabetes of actually upgraded adherence to the MedDiet was found in the PREDIMED trial among men and women at high cardiovascular risk. The use of yearly repeated measures of adherence to the diet in a large randomized trial represents the novelty of our study. Participants who exhibited a higher adherence during the trial –regardless of their randomized group– had a substantially lower risk of type 2 diabetes. Even after adjusting for the randomized group, a highly significant inverse linear dose–response relationship was noted for each 2-point improvement in MEDAS and higher adherence to the MedDiet linearly resulted in lower risk of diabetes, regardless of the provision of extra virgin olive oil or nuts in the intervention program. In addition, an objective multi-metabolite signature of adherence to the MedDiet measured in plasma [