Introduction
obesity, LGA, pre-eclampsia, hyperinsulinism, weight gain, hyperglycaemia
OBESITY, PRE-ECLAMPSIA, DIABETES IN PREGNANCY, TYPE 1 DIABETES, HYPERINSULINISM, PREGNANCY COMPLICATIONS, ADIPOSITY, NEONATAL HYPOGLYCAEMIA, HYPERGLYCAEMIA, COMPLICATIONS
Type 1 diabetes in pregnancy is associated with perinatal complications including pre-eclampsia, large for gestational age (LGA) and neonatal hypoglycaemia, attributed to sustained maternal hyperglycaemia [LGA is likely to involve altered carbohydrate, protein and fat metabolism and is influenced by multiple factors, including maternal obesity [Using samples from the CONCEPTT RCT, we assessed metabolomic and lipidomic changes associated with modifiable risk factors for suboptimal outcomes (hyperglycaemia, maternal BMI, gestational weight gain, habitual diet) and specific pregnancy complications, including LGA and offspring adiposity, neonatal hypoglycaemia, offspring hyperinsulinism and pre-eclampsia in pregnancies affected by type 1 diabetes.