Primary outcome and objectives
MAPT
ALZHEIMER
The primary outcome measure was the change in cognitive composite score after a 1, 3, and 5-year follow-up. We used a composite of four measures, close to the PACC (Preclinical Alzheimer Cognitive Composite), well established to show sensitivity to decline in early stages of AD [The main objectives were to assess according to amyloid blood status: (1) the cognitive effect of MAPT interventions at 12 and 36 months and (2) the long-term impact at 60 months after 2-year interruption of these interventions.