Graphical representation of the relationship between the p-values of the combined test (color coded), the lymphoblastoid cell line expression test (x-axis), and the whole-exome sequencing association test (y axis): We see that the majority of the genes that are associated with a significant combined test statistic show very low p values for the expression test and that the p-value of the combined test increases with the p-value of the association test.
cancer, death
CANCER, HAND INFECTION
The functional characterization of these genes using the Reactome database identified 14 significantly enriched pathways The KEGG analysis identified 16 enriched pathways. These pathways were involved in “cell growth and death” (p53 signaling pathway, cellular senescence), “signaling molecules and interaction” (cytokine-cytokine receptor interaction), cancer, and infection (