Pharmacokinetics
MF concentrations in both plasma and skin reached a steady state by day 28, which continued to day 42 for arm 1, with a median skin to plasma concentration ratio of 1.46. Fast plasma clearance of PM was observed on the first and last days (days 1 and 14) of treatment in the intensive PK cohort, with maximum plasma values reached 1 hour after treatment (arm 1). PM plasma exposure was higher on day 14 compared to day 1, suggesting time-varying drug clearance. The median skin to plasma concentration ratio of PM was 0.44, which was calculated based on patients with plasma samples collected between 0.5 and 2.5 hours after the day 14 dose administration (around C