INTRODUCTION
shock, bacterial endocarditis, liver abscess, intra‐abdominal malignancies, diabetes
INFLAMMATORY RESPONSE, PERIODONTAL INFECTION, SHOCK, LIVER ABSCESS, DIABETES
A liver abscess (LA) is a focal, infectious lesion of the liver caused by microorganisms, such as bacteria, fungi, or amoebas via arterial, venous, biliary tract, and direct dissemination, and is one of the more common acute critical illnesses in the intensive care unit (ICU).The direct hematogenous spread of systemic bacteria, such as bacterial endocarditis or periodontal infections, is known to produce PLAs. Significant risk factors for these processes include immunosuppression, liver transplantation, diabetes, biliary procedures, and intra‐abdominal malignancies.The pathophysiologic mechanism underlying infectious shock due to an unliquefied PLAs is primarilyIt is known that activation of the MyD88‐dependent pathway to induce an inflammatory response is one of the main pathways leading to infectious shock due to a bacterial LA,Urinary trypsin inhibitor, also known as ulinastatin (UTI),It has been shown