Discussion
cancers, death, fibrosis
FAP, CANCERS, METASTASIS, GALLBLADDER CANCER, FIBROSIS, MALIGNANCIES, TUMOUR, LIVER METASTASIS, DIGESTIVE SYSTEM CANCERS
Recent PET/CT studies with FAP inhibitors have been well developed, revealing strong PET signals across dozens of major cancers, especially digestive system cancers [Our study demonstrated that [The liver is the main site of metastasis and a major cause of death in digestive system malignancies, leading to short PFS and extremely poor prognosis [In addition to liver metastasis, [The expression of FAP is also widely reported to be avid in tissue modelling, wound healing, and inflammation-induced fibrosis [Altogether 2 primary tumour lesions demonstrated false-negative uptake of [We know that sensitivity and specificity are equally important when Youden’s index is used to obtain the best cut-off value. Previous study adopted cut-off value based on the highest Youden’s index [There are several limitations to this study. First, a small patient cohort limited the statistical significance for some kinds of cancers, such as oesophageal, pancreatic, and gallbladder cancer. Second, although being the ideal reference standard, histopathological examination was not available in all lesions because of ethical and technical reasons. Third, further prospective studies with larger populations in head-to-head comparisons of [Despite these limitations, to the best of our knowledge, this article might be the first application of a new 