Introduction
AML, aggressive hematologic malignancy
ACUTE MYELOID LEUKEMIA, AML
Acute myeloid leukemia (AML) is an aggressive hematologic malignancy most commonly diagnosed in patients aged 65–74 years [Intensive (7 + 3) chemotherapy usually includes a cytarabine and anthracycline backbone [The Hedgehog signaling pathway is critically involved in embryonic patterning and organ development, including hematopoiesis [