Methods
This observational cohort study using data from an ongoing clinical trialPatients with a COWS score of 8 or higher received 8 mg of sublingual buprenorphine in the ED and were discharged with a prescription for 16 mg/day. Individuals with COWS scores of 4 to 7 received uniform instructions for unobserved induction, up to 12 mg the first day, and then 16 mg/day. In the extended-release buprenorphine group, on the basis of dose equivalency to 16 mg of sublingual buprenorphine, patients received 24 mg of injectable CAM2038 in the ED during the index visit and follow-up.