Introduction
intravenous/intraarterial, physical disability
ADVERSE EVENTS, STILL, PHYSICAL DISABILITY, CEREBRAL PALSY (CP)
Cerebral palsy (CP) is the leading cause of physical disability in children [Several stem cell transplantation schemes have been applied in CP patients, like intrathecal administration (brain stereotactic surgery, lumbar puncture) and intravenous/intraarterial injection. Still, they reflect some drawbacks, such as procedure-related adverse events (AEs) [As we all know, motor function deficits occur as a result of brain function and structure injury. Although clinical scale evaluation could intuitively reflect the improvements of some symptoms, it is difficult to provide direct evidence for the alterations in brain function and structure. EEG is a commonly used method to evaluate brain function in the clinic. The sleep EEG was a reliable index of the brain structural and functional changes that could reflect the brain cortical reorganization and synapses pruning of neural activity in children and adolescents [Herein, we conducted an open-label randomized controlled clinical trial to evaluate the safety and efficacy of intranasal administration of NSCs for CP for the first time. And we performed FBN analysis based on sleep EEG and VBM analysis based on T1-weighted images before and after treatment to evaluate the effects of NSCs on brain function and gray matter structure.