Conclusions
overweight or obesity
METABOLIC SYNDROME
In this interim subgroup analysis of body composition in the PREDIMED-Plus RCT, we found evidence that a 3-year weight-loss intervention with energy-reduced MedDiet and PA may mitigate age-dependent changes in body composition by reducing total and visceral fat and delaying loss of lean mass in middle-aged and older adults with overweight or obesity and metabolic syndrome. These changes are likely of public health and clinical relevance. Given the metabolic relevance of specific body components, especially visceral fat and lean mass, the benefits of this lifestyle intervention could be very promising. However, continued follow-up is warranted to confirm the long-term consequences of these changes on health.