Treatment and assessments
toxicities, Cancer
CANCER, DISEASE PROGRESSION, ADVERSE EVENT, ADVERSE EVENT
Patients received 12 mg of anlotinib (Chia-tai Tianqing Pharmaceutical Co., Ltd.), orally once daily (2 weeks on and 1 week off), until disease progression or intolerable toxicities. Dose modification was allowed, with two levels of reduction (from 12 mg/day to 10 mg/day and 8 mg/day), for anlotinib-related toxicities according to protocol-specified criteria (generally for grade 3/4 toxicities). If more than 2 levels of dose modifications were required, treatment was terminated.Responses were assessed by CT and MRI per RECIST v1.1 every two cycles during the anlotinib treatment. Adverse events (AEs) were graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE) v5.0.Plasma EBV DNA copy number was determined at baseline and every 3 weeks until disease progression by quantitative reverse transcription polymerase chain reaction with probes against EBV genes.