In vivo studies
Female BALB/c nude mice at 6 to 8 weeks of age were obtained from Shanghai Lingchang Biotechnology Co. Ltd. The mice were housed in SPF-class independent ventilation cage (4 animals per cage). They were reared at 20–26 °C with a humidity of 40–70%, 12/12 dark/light cycles, and had free access to food and water ad libitum. Ba/F3 cells expressing EGFR A767_V769dup (5 × 10