Authors’ contribution
CDO, ROP
All authors participated in the concept and design of this study protocol. All authors approved this final draft for submission. AHG, GPSJ, BBV, AM, GLR and ROP supervised all the surgical and clinical aspects to be studied in this trial. CDO supervised all radiological assessment aspects to be used in this trial. TJ, RDA, FRK and PBA supervised all clinical and radiation oncology aspects to be considered in this manuscript. LARCC contributing group is responsible to recruit patients from all other institutions. All of them had approved the final version of this manuscript.