Biomarker analysis
PD, TNF-α
We found that the levels of Eotaxin (CCL11) and MCP-1 (CCL2) were significantly higher when patients were at PR status compared to those at PD (iuPD/icPD) status. On the contrary, the levels of TNF-α and VEGF were significantly lower when patients were at PR status compared to those at PD status (as shown in Fig. Potential biomarkers associated with efficacy. The responses at different time points when the cytokines were measured were showed in the upper panel. Levels of serum cytokines at different treatment cycles from 8 patients were analyzed against the corresponding response status. Among these cytokines, Eotaxin and MCP-1 levels showed a positive relationship with PR status, while TGF-alpha and VEGF levels correlated with PD (iuPD/icPD) status. Unpaired T- test was performed to analyze the difference of serum cytokines between PR and PD groups. 