Conclusion
The good performance of the best available RDTs allows point of care management of patients at primary care level, as well as community testing aimed at stopping transmission chains. RDT results allow immediate isolation of the vast majority of contagious individuals, without confining unnecessarily those who are not. The almost perfect concordance between saliva PCR and NP PCR results, the ease of administration and the safety of the procedure could trigger change in sampling method using saliva as reference standard, at least in outpatients who have higher viral loads than inpatients. RDT complies with the ASSURED (Affordable, Sensitive, Specific, User-friendly, Rapid and robust, Equipment-free and Deliverable to end-users) criteria, which makes them very useful in primary care practices, and, thanks to its very low price, even more so in resource-constrained settings [