Acknowledgements
The authors would like to thank Do Thi Hau, Ngo Hong Thuy, Pham Thi Thu Trang, and Do Thu Huong at National Children’s hospital for patient care, samples collection, and technical assistance; Bui Thi Phuong Anh at ANABIO R&D for assistance in study protocol preparation; Nguyen Tue Nam at LiveSmile Foundation for assistance in sample analysis and data sorting; Mai Thanh Trung for drawing Fig. 