ASC and MEQ-30
Auditory alterations, Oceanic boundlessness’, Anxiety, MEQ-30
AUDITORY ALTERATION
LMM analysis revealed significant increases on the 5D-ASC subscales ‘Oceanic boundlessness’ and ‘Visual restructuralization’ for all doses compared with placebo. There were significant increases for Dose 2, 3 and 4 compared with placebo on the 5D-ASC subscale ‘Dread of ego-dissolution’, and for Dose 2 and 3 compared with placebo on the 5D-ASC subscale ‘Auditory alterations’. For the 11D-ASC, LMM analysis showed significant increases on the subscales ‘Unity’, ‘Meaning’, ‘Spiritual experience’ ‘Blissful state’, ‘Insightfulness’, ‘Complex imagery’, and ‘Elementary imagery’ for all doses compared with placebo. Additionally, there were significant increases for Dose 3 compared with placebo on the subscale ‘Disembodiment’, and significant increases for Dose 2 and 3 compared with placebo on the subscale ‘Impaired cognition’. No significant differences between any dose and placebo were found for the subscales ‘Anxiety’ and ‘Audio/visual synaesthesia’. Lastly, LMM analysis revealed significant increases in the MEQ-30 total as well as all subscales for all doses with respect to placebo. Results are shown in Retrospective assessment of subjective effects induced by continuous infusions of placebo and different doses of DMT. LMM analysis revealed: (a) a significant increase for all doses compared with placebo in ‘Oceanic boundlessness’ and ‘Visual restructuralization’, for Dose 2, 3 and 4 compared with placebo in ‘Dread of ego-dissolution’, and for Dose 2 and 3 compared with placebo in ‘Auditory alterations’, (b) significant increases for all doses compared with placebo in ‘Unity’, ‘Meaning’, ‘Spiritual experience’ ‘Blissful state’, ‘Insightfulness’, ‘Complex imagery’, and ‘Elementary imagery’, for Dose 3 compared with placebo in ‘Disembodiment’, and for Dose 2 and 3 compared with placebo in ‘Impaired cognition’, and (c) a significant increase for all doses versus placebo on the MEQ-30 total and all subscales. Summary statistics can be found in 