Conclusion
inflammation, asthma exacerbations, airway inflammation
INFLAMMATION
Airway challenges that induce bronchoconstriction (methacholine) or inflammation and bronchoconstriction (mannitol) did not result in immediate measurable or clinically meaningful acute changes in systemic inflammation or vascular function. These findings suggest that airway inflammation and bronchoconstriction immediately following asthma exacerbations are unlikely to be the sole mechanisms for the increased cardiovascular risk and other factors such as the impact of inhaler medications on cardiovascular health and the real-world impacts of asthma exacerbations need to be further examined.