Author contributions
MA MG was involved in the conception, design, and conduct of this study, and, with PM, in the analysis and interpretation of the results. PM, MRC and MAMG wrote the first draft of this manuscript. All authors edited and reviewed the manuscript and provided important intellectual and scientific content. All authors approved the final version of the manuscript. MA, MG is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.