Ethical approval and consent to participate
malaria infection
Ethical approval for this study and the methods described has been obtained from the ethics review boards of the Ministry of Health in Benin (N°6/30/MS/DC/DRFMT/CNERS/SA), the institutional review board of the London School of Hygiene and Tropical Medicine (N°16,237), and the WHO Research Ethics Review Committee (ERC.0003153). The cRCT is registered on clinicaltrials.gov (NCT03931473). Heads of households will give informed consent prior to their participation in the study. The consent form will be written in French and explained to them in their local language. Where the individual is unable to read or write, their fingerprint will be taken, and a signature obtained from a witness to the informed consent procedure. All personal data will be anonymized prior to data processing. Written informed consent will also be obtained from all human volunteer sleepers for experimental hut trials prior to participation. Sleepers will be offered a free course of chemoprophylaxis spanning the duration of the study and 4 weeks following its completion to mitigate malaria infection risk. Approval for use of guinea pigs for tunnel tests has been obtained from the LSHTM Animal Welfare Ethics Review Board (Ref: 2020–01). The methods described in this paper will be carried out in accordance with relevant guidelines and regulations.