Discussion
glioblastoma, ovarian cancer, EEP, high-grade glioma
GLIOBLASTOMA, OVARIAN CANCER, DISEASE
Lisavanbulin is a water-soluble lysine prodrug of the active synthetic small molecule avanbulin, which can be administered intravenously in the absence of solubilizing excipients, and has high oral bioavailability. Study CDI-CS-001 showed that the RP2D of 30 mg/mWhen administered as a 48-hour IV infusion, the RP2D was determined to be 70 mg/mSignals of efficacy were observed following treatment with lisavanbulin as a 48-hour IV infusion. In the ovarian cancer cohort, three patients had best response of stable disease, with lesion size reductions after two cycles of treatment (EEP). In the glioblastoma cohort, one patient with partial response was treated for 16 cycles, and one patient with stable disease as best response was treated for 10 cycles, corresponding to a disease control rate of 25% after eight cycles of treatment, and an objective response rate of 12.5% in the EEP.In a Phase 1 study with continuous daily oral administration of lisavanbulin, two of 28 patients with recurrent or progressive glioblastoma or high-grade glioma achieved long-lasting objective responses (CDI-CS-002, NCT02490800 [