2.2. Proteomics
Based on paired comparisons and the significance cutoff, a total of 33 differentially expressed proteins (DEPs) of interest were selected (6 upregulated and 27 downregulated proteins), representing the union of statistically significant upregulated and downregulated proteins for each treatment at Weeks 4 and 8 (FDR < 0.05 and absolute fold change [|FCH|] > 1.5). Modulation of these DEPs appeared to be dose dependent both at Week 4 (