Participants
The first enrollment was February 15, 2018, and the last study visit was March 11, 2020. The study goal was to enroll 300 participants, but it was stopped early due to the COVID-19 pandemic. Of 307 individuals screened, 24 were not interested in the study, and 95 were excluded based on exclusion criteria. A total of 188 participants (mean [SD] age, 49.1 [12.5] years; 102 [54%] female) were enrolled and randomized, with 127 participants choosing to use varenicline, including 64 randomized to adaptive treatment and 63 randomized to standard treatment, and 61 participants choosing to use nicotine patches, including 31 randomized to adaptive treatment and 30 randomized to standard treatment. At baseline, the mean (SD) Fagerstrom Test for Cigarette Dependence