CONCLUSIONS
hyperglucagonemia, cirrhosis, metabolic dysfunction, diabetes
INSULIN RESISTANCE, CIRRHOSIS, DIABETES
In this study, we found insulin resistance and hyperglucagonemia in patients with MAFLD without diabetes, as well as in patients with MAFLD and cirrhosis. Patients with MAFLD showed significant glucoregulatory disturbances and insulin resistance in response to a standardized meal, indicating distinct postprandial metabolic dysfunction and a condition of pre‐diabetes in these patients. Moreover, we found increased FGF21 concentrations in MAFLD that were positively associated with age, fasting glucose, and BMI. Additional studies are needed to investigate postprandial metabolic dysfunction in patients with MAFLD.