Inclusion criteria
choroideremia
DISEASE, CHOROIDEREMIA
Participants were male (assigned by the investigators), ≥18 years of age and willing and able to provide informed consent. Participants could be of any race or ethnicity; they self-reported this information; and they were not obligated to disclose it. Because of occasional clinical misdiagnosis of choroideremia, participants must also have had a documented, genetically confirmed diagnosis of choroideremia before randomization. Participants must have had active disease clinically visible within the macular region in the study eye and a BCVA of 34–73 ETDRS letters (worse than or equal to 6/12 or 20/40 Snellen acuity, but better than or equal to 6/60 or 20/200 Snellen acuity in the study eye) to be eligible for participation in the trial. This range excluded both the participants for whom visual acuity readings were so poor that they became unreliable and participants for whom visual acuity readings were so good that there would be no potential for a three-line gain without hitting a ceiling of 6/5 or 20/16 Snellen acuity.