Headache impact
migraine, Headache
MIGRAINE
Mean HIT-6 total scores were similar across treatment groups at baseline (66.0–66.6), indicating a population with severe headache-related life impact. Improvement was observed at the first assessment after the first eptinezumab infusion for those initially treated with eptinezumab and for those switching from placebo to eptinezumab for the extension period (Fig. 
Mean changes from baseline in HIT-6 total score (MMRM; efficacy analysis set). BL, baseline; Epti, eptinezumab; HIT-6, 6-item Headache Impact Test; LS, least squares; MMRM, mixed model for repeated measures At baseline, the proportion of migraine attacks with severe intensity ranged 37.6–47.3% across treatment groups. Reductions in severe migraine attacks with eptinezumab were sustained or further improved with continued treatment (Fig. 
Mean changes from baseline in the percentage of migraine attacks that were severe (MMRM; efficacy analysis set). BL, baseline; Epti, eptinezumab; LS, least squares; MMRM, mixed model for repeated measures