Exploratory Analysis
To investigate the efficacy of L-citrulline supplementation on maternal cardiovascular function, the association between log change in AAR was plotted against the change in cardiovascular parameter between baseline and 8 weeks. There was no consistent reduction in BP (clinic or ambulatory), PWV or peripheral vascular resistance in participants in whom there was an increase in AAR (Fig. Change in peripheral cardiovascular parameters from baseline to the end of treatment by biochemical change in arginine:ADMA ratio (AAR). 