Network analysis and cluster of the isolated complications.
ascites, CKD, abnormal metabolic syndromes, SAHs, fibrosis, gastrointestinal ulcer bleeding, COPD, splenomegaly, granulomatous, metabolic abnormalities, gastroesophageal variceal bleeding
ASCITES, PORTAL HYPERTENSION, COLORECTAL CANCER, COLORECTAL POLYP, PROLIFERATION, RESPIRATORY FAILURE, GASTROINTESTINAL ULCER BLEEDING, RIGHT HEART FAILURE, FIBROSIS, COPD, SECONDARY, SYNDROMES, MINIMAL HEPATIC ENCEPHALOPATHY, HEPATIC ENCEPHALOPATHY, GRANULOMATOUS INFLAMMATION, METABOLIC SYNDROME, PULMONARY HYPERTENSION
Through network analysis, three major clusters were noted. We named the first cluster as schistosomal abnormal metabolic syndromes (SAMs), and they included metabolic syndrome, CKD, pulmonary hypertension, right heart failure, COPD, and respiratory failure, which were related to chronic metabolic abnormalities. We named the second cluster schistosomal abnormal hemodynamics syndromes (SAHs), and they included minimal hepatic encephalopathy, hepatic encephalopathy, gastroesophageal variceal bleeding, and gastrointestinal ulcer bleeding, which were related to severe portal hypertension and portosystemic shunting. We designated the third cluster schistosomal inflammatory granulomatous syndromes (SIGs), and they included fibrosis, ascites, splenomegaly, colorectal polyp, and colorectal cancer, which were related to fibrosis and proliferation of the portal system, and colorectal mucosa secondary to granulomatous inflammation (Node centrality is shown in Estimated network structure based on the training cohort using the IsingFit model (the Fruchterman–Reingold algorithm was used for node placement). (