Randomization
The interactive network response system Clinflash IRT v2.2.10 (Clinflash Healthcare Technology, Jiaxing Clinflash Computer Technology Co. Ltd.) automatically distributed groups randomly according to the order of entry to reduce the test bias caused by sampling error. The random table was generated by the specified person, and the random table was generated by SAS version 9.4 (SAS Institute, Cary, NC) according to the preset number of seeds and the number of blocks. The ratio of the trial group to the control group was 1:1 by using the block randomization design according to central stratification. Any subjects who had completed randomization but withdrew from this clinical trial before the commencement of treatment were retained.