Effect of recent BCG vaccination
TB, infections
INFECTIONS
Due to its beneficial off-target effects in protecting against unrelated infections (Our findings, that recent BCG vaccination did not alter IgG responses to CoronaVac or ChAdOx1-S, are consistent with a study that reported the lack of an increase in B cell responses to SARS-CoV-2 Prior mycobacterial exposure among placebo-vaccinated participants may have reduced the observed effects of recent BCG vaccination in our study. In animal models, exposure to environmental mycobacteria, such as Being based in a high-tuberculosis (TB) prevalence setting, most study participants had received prior BCG vaccination, over 95% of which was more than 5 years prior, likely as part of routine infant BCG vaccination programmes. Infants whose mothers had also been BCG-vaccinated in the past have been reported to have stronger clinical and immunological off-target effects of BCG vaccination (