Intraperitoneal chemotherapy
bloating, allergic reaction, diarrhea, abdominal pain, fever, infection, skin rash, hypotension, shivering, chills, shortness of breath
ADVERSE REACTIONS, ALLERGIC REACTION, INFECTION, CATHETER INFECTION, DECUBITUS, COMPLICATIONS
The IPC will be performed on an outpatient basis, concomitantly with four cycles of conventional chemotherapy. Paclitaxel (PTX) (40 mg/mThe intraperitoneal PTX infusion must be preceded by an intravenous infusion of dexamethasone (20 mg) and diphenhydramine (50 mg), both intravenously, 30–60 min before PTX. Also, the PTX solution will be preceded by an infusion of 500 mL of saline heated in an oven at a temperature of around 37°C (1 h infusion), followed by PTX diluted in 500 mL of saline solution heated to 37°C (1 h infusion). During the infusion, the patient must change positions every 15 min in the following order: right lateral decubitus, left lateral decubitus, supine decubitus, ventral decubitus, and Patients will be evaluated before each intraperitoneal infusion, and treatment will be discontinued if inflammatory or infectious peritonitis is suspected, catheter infection is present, or performance deterioration status is noted for ECOG 2. During all the infusions, the presence of infusion-related symptoms will be assessed. Among potential complications, common adverse reactions include mild abdominal discomfort, bloating, diarrhea, and chills. Potentially serious symptoms include any suspected allergic reaction or infection, skin rash, moderate to severe abdominal pain, shortness of breath, hypotension, fever, and chills accompanied by shivering. In these cases, the infusion will be stopped immediately, and the patient will be evaluated by the medical team.The peritoneal catheter will be removed during the second SL, or earlier if the patient is withdrawn from the study.