Sample size estimation and randomization
INFLUENZA
Taking time of temperature recovery as clinical main efficacy indicator, we calculate two groups’ sample size using mean superiority test formula. According to data of efficacy evaluation about adult influenza treating with RDN and Oseltamivir in the early stage, the per protocol set (PPS) of time of temperature recovery comes: Oseltamivir is 46.50 ± 1.74(h) and RDN is 30.47 ± 1.69(h); so that δ for 15.35 h, 100 participants will be required for each group, and 200 is the total. If the 20% dropout rate is considered, 240 cases were planned to be observed. We adopt the method of center stratified block randomization in trial: there is 10 centers, 4 segments, each center has 24 cases and each group has 12 cases.Randomization will be used for patient allocation [