Circadian oscillation of metabolic enzymes
Using publicly available data, we examined whether metabolic enzymes of AZA/6-MP were under circadian regulation. Several key enzymes in the metabolic pathway such as hypoxanthine guanine phosphoribosyl transferase and xanthine dehydrogenase had robust circadian oscillation based on time of day. Hypoxanthine guanine phosphoribosyltransferase activity had a period of 24.0 with a q-value < 0.01, and xanthine dehydrogenase had a period of 25.0 with a q-value < 0.01 (Figure Circadian oscillation of metabolic enzymes. Using publicly available data from the Circadian Expression Profiles Database (