Introduction
HEAT
Electronic nicotine delivery systems (ENDS), which heat a solution containing nicotine and typically propylene glycol and glycerin without causing combustion, generate aerosol containing substantially fewer and lower levels of toxicants relative to tobacco cigarette smokeThe continued growth of ENDS use and the multitude of available brands, styles, and flavors has resulted in concerns about the products’ potential abuse liability (AL)Multiple methodologies have been employed to assess a product’s AL in humans, most of which involve comparing the product of interest to comparators with known levels of abuse liability. One such methodology is based on a standard approach for pharmaceutical AL assessment that has been adapted for tobacco products