2.6. Outcome measure
bleeding, Catheter occlusion, catheter occlusion, pain, blood coagulation
GASTROINTESTINAL BLEEDING, BLEEDING, SUBCUTANEOUS HEMATOMA
Main outcome indicator: activated partial thromboplastin time (APTT) at 10 min after tube locking. Secondary outcome indicators: APTT at 7 d after initial tube locking, prothrombin time (PT) at 10 min after tube locking and 7 d after first tube locking, international normalized ratio (INR), fibrinogen (FIB), thrombin time (TT), catheter indwelling time, catheter occlusion rate, and CRBSI rate. Safety evaluation index: bleeding around the puncture site and subcutaneous hematoma rate, gastrointestinal bleeding rate, rate of ionized calcium < 1.0 mmol/L.Judgment criteria are as follows. Four indexes of blood coagulation include the blood of patients was drawn by venipuncture of peripheral blood before tube locking, 10 minutes after tube locking, and 7 d after the first tube locking, respectively, then comparing APTT, PT, INR, FIB, and TT. Catheter occlusion standard: (i) Partial occlusion. Infusion can be performed but blood cannot be withdrawn, the infusion rate is slowed down, local pain is present, there is resistance to flushing, or exudation occurs. (ii) Complete occlusion. It cannot be infused, withdrawn blood, or is unable to flush. When any of the above occurs, it is indicated by catheter occlusion [