Interventions
ADVERSE EVENTS, EVENTS
Participants followed a low-calorie diet of 800 kcal/day (meal replacement products, Cambridge Weight Plan) for eight weeks [The exercise intervention was designed to meet the WHO recommendations on physical activity: a minimum of 150 min/week of moderate-intensity or 75 min/week of vigorous-intensity aerobic physical activity or an equivalent combination to reach adequate exercise volume (duration × intensity). Participants randomized to exercise were encouraged to attend supervised group sessions twice a week and perform exercise individually twice a week. Exercise was targeted at 80% of maximal heart rate, and heart rate monitors were worn at all exercise sessions to assess adherence. Participants not randomized to exercise were instructed to maintain habitual physical activity until the end of the trial. Details on the exercise intervention have been reported elsewhere [Study medication, liraglutide 6 mg/mL (Saxenda), or volume-matched placebo was injected subcutaneously via pens by the participants, commencing at 0.6 mg/day with weekly increments of 0.6 mg/day after consultation, eventually reaching 3.0 mg/day. Participants who had unacceptable adverse events at the targeted dose received the maximally tolerated dose at which they did not have such events. Participants remained enrolled if the medication was discontinued [