Study Cohort, Design, and Outcome
TTM, Coma, cardiac arrest
COMA, OUT-OF-HOSPITAL CARDIAC ARREST, CARDIAC ARREST
This study is a targeted analysis of serum p-tau181, Aβ42, and Aβ40 concentrations in participants from the international multicenter Target Temperature Management After Out-of-Hospital Cardiac Arrest (TTM) trial. The trial recruited unconscious (Glasgow Coma Scale score less than 8) adult patients (18 years and older) with out-of-hospital cardiac arrest of presumed cardiac origin from November 11, 2010, to January 10, 2013.To allow for optimal assessment of possible changes in blood levels of p-tau and Aβ, we initially selected 80 participants (discovery cohort) from the TTM trial evenly distributed between good neurological outcome (Cerebral Performance Category scale score 2 or less) and poor neurological outcome (Cerebral Performance Category scale score 3 or greater). Good and poor outcome groups were further divided by low and high levels of serum NfL as stipulated in eTable 1 in The validation cohort was an unselected sample encompassing the full TTM trial, consisting of 717 participants. In the validation cohort, 357 participants had a good neurological outcome and 360 had a poor neurological outcome (