MAD
For the MAD cohorts, across the entire dose range steady‐state concentration was achieved from Day 3 or earlier at predose. Low concentrations of KCL‐286 were detected around 1 ng/mL from 36 or 48 h postdose through to the follow‐up time (nominally 168 h after dose 7). Over the entire dose range investigated there was a trend to subproportional exposure with increasing dose on Day 1 of the MAD being essentially similar to that observed from the SAD up to 100‐mg single dose. A similar relationship was apparent on Day 7 of the MAD, but at plasma exposures approximately half that found on Day 1 (Table 