Adherence to the POINCARE-2 strategy
Independent research nurses collected daily body weight, biological assays, and treatment prescriptions from Day 0 to Day 14 from medical records. To assess contamination during the control period (i.e., whether POINCARE-2 strategy was already partially implemented before the planned implementation date), data concerning components of POINCARE-2 strategy (i.e., body weight, biological assays, and treatment prescriptions) were also collected by independent research nurses for patients included during the control period. Weight was routinely collected daily from Day 0 to Day 14 in the strategy group, and on Day 0, Day 7, and Day 14 in the control group (or more frequently when weighing was performed more frequently as part of routine care during the control period).To assess adherence to the POINCARE-2 strategy once the strategy was implemented, we used fluid balance estimates and furosemide and albumin prescription as indicators of adherence. Fluid balance was assessed by using (i) weight evolution between Day 0 and Day 7, defined as the difference between weight at Day 7 and weight at Day 0; (ii) weight evolution between Day 0 and Day 14, defined as the difference between weight at Day 14 and weight at Day 0; (iii) average fluid balance from Day 0 to Day 7, defined as individual arithmetic mean of daily fluid balance (i.e., difference between individual volume of fluid intake and output) over 7 days after Day 0; and (iv) average fluid balance from Day 0 to Day 14, defined as individual arithmetic mean of daily fluid balance (i.e., difference between individual volume of fluid intake and output) over 14 days after Day 0. Furosemide and albumin prescriptions were assessed using (i) total dose of diuretics from Day 0 to Day 14, defined as the cumulated dose of diuretics administered to a patient over 14 days after Day 0, and (ii) total dose of albumin 20% from Day 0 to Day 14, defined as the cumulated dose of albumin 20% administered to a patient over 14 days after Day 0.