Discussion
stroke, anti-hypoxic/ischemic injury
STROKE
Changes in the hypothalamic-pituitary-adrenal (HPA) axis, the sympathetic nervous system, and the levels of several hormones, including natriuretic peptides, melatonin, and IGF-1, occur after a stroke [BNP, Corin, and NEP are all important components of natriuretic peptides (NPs) [LCZ696 (sacubitril/valsartan), the first of the new angiotensin receptor-neprilysin inhibitor (ARNI) drug class, contains equimolar amounts of sacubitril and valsartan [Elevated natriuretic peptide levels are associated with worse clinical outcomes in stroke, which might demonstrate the relatively low level of protection brought on by this endogenous effect [BNP levels are valuable predictors of stroke outcome [BDNF plays an important role in neuroprotection and is involved in the anti-hypoxic/ischemic injury pathway [