Authors’ contributions
MH, MP
MEA
MH and SF performed most of the experiments and data acquisition and also wrote the manuscript. SK carried out the synthesis of the BCc1 and Hep-S nanomedicine. AF, SL, SM, MM, JH, MB, HZ, AN, MP, PK, and SY collected the data and selected the patients. MHN contributed to the conception and design of the BCc1 and Hep-S nanomedicine. MEA and HJ designed the study. All authors read and approved the final manuscript.