4.1. Study limitations
CIPN
First, the small sample size and unplanned nature of the ancillary analysis without statistical power limit the strength and clinical impact of our findings. Second, the study assessment of persistent CIPN was based on a subjective patient questionnaire. Objective evaluation, such as the Semmes-Weinstein monofilament test, should be integrated to the robustness of our finding. Finally, while the degree of persistent CIPN appears to be fixed over time, additional serial assessments of CIPN on individual cases may strengthen our study findings.