3.3. Safety Assessment of NRE Infusion 
in bowel movements, overweight, liver and kidney functions
RENAL, ACID REFLUX, OBESE
Both doses of NRE infusions were found to be well tolerated. Mild undesirable effects were observed in three overweight/obese participants from the high-dose group, including temporary alterations in bowel movements, a diuretic impact lasting for two days, and periodic acid reflux. To assess safety, we examined the effect of daily consumption of NRE on various indicators such as hematological and hemodynamic parameters, liver and kidney function tests, and blood glucose levels. All participants exhibited normal blood biochemical values during the screening phase for study enrollment. The results are presented in Based on our findings, there were no significant differences observed in RBC count, WBC count, Hb level, Ht, and Plt count between the groups receiving two different doses of NRE for 10 days. Furthermore, the hemodynamic parameters, including systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse rate, exhibited no significant differences in healthy participants. However, overweight/obese participants showed a lower SBP in both groups and a lower DBP in the high-dose group after 10 days of intake of NRE, which remained within normal limits (<140 mmHg for SBP and <90 mmHg for DBP).Concerning hepatobiliary indices, including serum AST, BT, BD, sAlb, ALT, ALP, and GGT, no differences were observed post-intervention compared to the baseline measurements. However, there was a significant reduction in ALT levels in the low-dose group of healthy participants, which remained within the normal range (Renal function tests, specifically BUN and sCr, demonstrated no significant differences before and after the intervention in healthy (Our preliminary results suggest the safety of daily consumption of NRE in terms of liver and kidney functions, encompassing both healthy individuals and those who are overweight or obese.