Discussion
diabetes
DIABETES
To our knowledge, this study is the first report on effects of the time of the day of MLE intake on postprandial glucose metabolism in young adults. The main finding was that acute intake of MLE in the evening, but not in the morning, significantly suppressed the iAUC and postprandial glucose concentrations. Our results reveal that MLE intake in the evening was effective in improving glucose tolerance, which is associated with diabetes development. They also provide novel evidence regarding the timing of MLE intake to elevate its antidiabetic effect from a chrononutrition perspective.Increasing evidence suggests that the postprandial glucose response to dinner is higher than that to breakfast [DNJ, derived from MLE, has been used in several countries to treat diabetes because of its effects on lowering blood glucose concentrations. Several studies have reported that MLE that contains DNJ possesses glucose-lowering and antidiabetic properties [There are some clinical implications from our results. First, regarding the dose of MLE, we decided to administer 6.0 mg of DNJ with a test meal in this study based on previous studies [