Introduction
anxiety, inflammation, psychiatric, depression, T2DM, Infection
INFLAMMATION, DISEASE, TYPE 2 DIABETES MELLITUS, INSULIN SENSITIVITY, INFECTION
Edited by: Jun Wang, Institute of Microbiology (CAS), ChinaReviewed by: Lin Jin, Kunming Institute of Zoology (CAS), China; Yipeng Wang, Soochow University, China; Xueqing Xu, Southern Medical University, ChinaThis article was submitted to Microbiome in Health and Disease, a section of the journal Frontiers in Cellular and Infection MicrobiologyPrevious studies have demonstrated that patients with type 2 diabetes mellitus (T2DM) often had the problems of fecal microbiota dysbiosis, and were usually accompanied with psychiatric comorbidities (such as depression and anxiety). Here, we conducted a randomized clinical study to analyze the changes in gut microbiota, serum metabolism and emotional mood of patients with T2DM after consumption of a high-fiber diet. The glucose homeostasis of participants with T2DM was improved by the high-fiber diet, and the serum metabolome, systemic inflammation and psychiatric comorbidities were also altered. The increased abundances of Accumulating studies have demonstrated that there were intimate correlations between type 2 diabetes mellitus (T2DM) and gut microbiota. By modulating the structure of gut microbiota, a specially designed high-fiber diet was proved to be able to provide obvious beneficial effects for patients with T2DM (The clinical symptoms of anxiety and depression were often observed in patients with T2DM, and the reason might lie in that the diabetic nutrient restrictions and the imbalanced gut microbiota influence the patient’s emotional state (Nowadays, personalized nutritional interventions based on transcriptomics, proteomics, and metabolomics techniques could provide additional benefits for patients with T2DM. Consumptions of functional foods and bioactive ingredients could enhance the anti-oxidant properties, the anti-inflammatory activities, the anti-cholesterol activities, and the insulin sensitivity of patients with T2DM (In this study, the profiles of fecal microbiota samples from patients with T2DM altered by a high-fiber diet were studied, and the relations between the microbial communities and the host’s clinical features were also determined and analyzed.