Secondary analyses of overall differences in outcomes
Overall weight and HbA1c: Mean and SD for weight and HbA1c for each of the three drugs were examined, with statistical differences across all three determined using mixed effects models with drug (3 level factor) as the fixed effect and participant ID as the random effect.Overall side effects: This analysis was descriptive examining the proportions reporting experiencing each of the 16 side effects the patients were asked about for each of the three drugs.Overall Tolerability: We report proportions not tolerating therapy (i.e. not completing at least 12 weeks of therapy) for each drug. As specified in the SAP, we compared tolerability using both a Mantel-Haenszel approach and a mixed effects model. Results were similar using both approaches, but for clarity we just present the p values based on the mixed effects model with tolerability as the outcome, drug and period as fixed effects, and participant ID as the random effect.