Responsiveness
To evaluate the extent to which the EoE-IQ detects change, correlations were calculated between change in EoE-IQ average score from baseline to week 24 and changes as assessed by the PGIS, PGIC, and other supporting PRO and clinical measures (DSQ, EoE-SQ, EoE-EREFS, and peak and categorized peak esophageal intraepithelial eosinophil count).ANOVAs were performed for differences in change in average EoE-IQ score from baseline to week 24 by responsiveness groups defined by (1) PGIS changes (improved: ≥ 1-point improvement; no change: 0-point change; worsened: ≥ 1-point worsening), (2) PGIC score (better: “A little better,” “Moderately better,” “Very much better”; no change: “No change”; worse: “A little worse,” “Moderately worse,” “Very much worse”), and (3) peak esophageal intraepithelial eosinophil count (responder: ≤ 6 eos/hpf; nonresponder: > 6 eos/hpf).In addition, standardized effect size (SES) statistics were calculated for within- and between-group changes. An SES of 0.20 to < 0.50 is considered to be small, 0.50 to < 0.80 to be moderate, and ≥ 0.80 to be large [