Clinical observations
lethargy, respiratory abnormalities, hunched, infection, inappetence
INFECTION, MINOR
NHPs exhibited clinical signs of infection, including lethargy and hunched posture, not eating, stool abnormalities, and respiratory abnormalities following infection. All (100%) animals exhibited inappetence within a week following the challenge, and 94% of animals in each treatment group exhibited stool abnormalities within the first eight days following the challenge. High proportions of animals in all groups (88% of IGIV-treated, 94% of 7.5 U/kg ANTHRASIL-treated, 100% of 15 U/kg ANTHRASIL-treated and 94% 30 U/kg ANTHRASIL-treated) had activity abnormalities. Relatively few animals exhibited respiratory abnormalities (44% of IGIV-treated, 19% of 7.5 U/kg ANTHRASIL-treated, 25% of 15 U/kg ANTHRASIL-treated and 19% of 30 U/kg ANTHRASIL-treated animals). The abnormalities were persistent in non-survivors. In contrast, only sporadic observations of inappetence and minor stool abnormalities were noted in the surviving animals a week after infection.