Introduction
Type 2 diabetes, dietary renal acid, diabetic, low renal acid load diet
TYPE 2 DIABETES, SECONDARY, INSULIN RESISTANCE, METABOLIC DISORDERS, TYPE 2 DIABETES
Type 2 diabetes is one of the most prevalent non-communicable metabolic disorders, that results in a high rate of morbidity and mortality, worldwide [Dietary intake is a determinant of acid production and may influence on acid–base balance in the body [One of the main indicators used to estimate the acid renal load is potential renal acid load (PRAL), which refers to the intestinal absorption of five nutrients, including protein, potassium, calcium, phosphorus, and magnesium. A positive PRAL indicates acid-inducing and a negative score indicates alkali-inducing properties [Several observational studies have been conducted to investigate the relationship between dietary acid load and glycemic control and metabolic indices. A prospective cohort study conducted on middle-aged subjects reported that a high acid-load diet was associated with a higher risk of type 2 diabetes [Although the number of observational studies that assessed the association between dietary acid load and glycemic control and metabolic factors are informative, no well-designed interventional study has been performed to detect the effect of dietary renal acid load on metabolic factors in type 2 diabetic patients. Therefore, in the present study, we aimed to evaluate the effects of a low renal acid load diet (LRALD) on, blood glucose, and insulin resistance as primary outcomes and anthropometric variables, blood pressure and lipid profiles as secondary outcomes in patients with type 2 diabetes.