Introduction
pulmonary toxicity, vascular endothelial dysfunction
TESTICULAR CANCER
The introduction of bleomycin, etoposide and cisplatin combination chemotherapy (BEP) has improved the long-term survival of patients with metastatic testicular cancer to more than 90% (Hanna and Einhorn Endothelial damage of the small vessels in the lung plays an important role in the development of bleomycin-induced pulmonary toxicity (Sleijfer Evidence mounts that engaging regularly in moderate-to-vigorous intensity aerobic physical exercise is beneficial for vascular endothelial function by increasing nitric oxide availability (Thompson et al. Based on these data, we hypothesized that structured physical exercise during BEP-chemotherapy attenuates pulmonary toxicity and vascular endothelial dysfunction in patients with metastatic testicular cancer. This exploratory analysis aimed to investigate the effect of a physical exercise intervention performed during or after BEP-chemotherapy on pulmonary function and markers of vascular endothelial dysfunction, measured before and post-chemotherapy, post-intervention, and 1-year post-intervention.