References
death, CKD, chronic kidney disease, DVT, septic shock, COPD
DEEP VENOUS THROMBOSIS, TUMOR NECROSIS, CVD, PULMONARY EMBOLISM, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, COPD, SEPTIC SHOCK, DVT
(Proinflammatory interleukins show decreases with a significant delta when evaluating the pretreatment and posttreatment levels. With Vit C, there is a decrease in IL-6 (Intrinsic and extrinsic pathway for induction of apoptosis. Intrinsic and extrinsic pathway for induction of apoptosis. (1) The extrinsic pathway of apoptosis can be activated by TNF-dependent Apo2L/TRAIL receptors. (2) In some extional cases, Apo2L/TRAIL can be intrinsically pathway activated by Bid. (3) The intrinsic pathway can be activated by DNA or microtubule damage, involving the interaction of some proteins such as BAX and BAK. (4) Apoptosis can also be promoted by activation of p53. Abbreviations: Apaf-1 = apoptotic protease-activating factor 1, Apo2L/Trail = Recombinant human apoptosis ligand 2/inducing tumor necrosis factor-related apoptosis ligand 2, FADD = the fas-associated death domain protein, GR = glutathione reductase, GSH = glutathione, GSSG = oxidized glutathione, HDemographic characteristics of patients in each group of treatment.Vit C: vitamin C; Vit E: vitamin E; NAC: N-acetylcysteine; MT: melatonin; TX: treatment; COPD: chronic obstructive pulmonary disease; CKD: chronic kidney disease; CVD: cerebral vascular dis-ease; DVT: Deep venous thrombosis; PE: Pulmonary embolism. Values are expressed as median (p25–p75); Statistical test: Kruskal–Wallis test, ¥ one-way ANOVA, § chi-squared test, and * Fisher’s exact test.Demographic characteristics of patients according to treatment group.Vit C: vitamin C; Vit E: vitamin E; NAC: N-acetylcysteine; MT: melatonin.Levels of cytokines in patients from the different treatment groups.Vit C: vitamin C. Vit E: vitamin E. NAC: N-acetylcysteine. MT: melatonin. MCP-1: chemotactic protein from monocytes 1: range test signaled by Wilcoxon. Values are expressed in pg/mL.Canonical correlation analysis between cases and controls with septic shock pretreatment.The canonical correlation revealed a significantly high correlation between the first (0.9529), the second (0.8643), and third (0.8218). Lambda test with an F = 0.001; the Lawley–Hotteling trace and Loy’s largest root yielded the same statistical significance.