Author contributions
PATHOLOGY
I.C.G.O., S.D.F., H.A.T. and M.A.D. provided a significant intellectual contribution to the study design and research, and performed and supervised the research. I.C.G.O. was the principal investigator of this trial. I.C.G.O., A.P.F., S.P. and E.M.B. assisted in collection of the clinical data. R.B. Jr and R.L. performed all the statistical analyses. I.C.G.O., S.D.F., A.P.F., I.J., T.D.H., M.R., J.R., M.I., T.D., C.L., N.J., T.R., S.P., R.N.A., M.K.W., A.D., C.Y., S.P.P., J.L.M., I.E.M., B.J.O., S.T., M.D., N.G.-T., J.A.W., H.A.T. and M.A.D. provided care for patients enrolled on this trial. S.D.F. and G.M.F. performed the murine-based experiments. L.H. and S.D. assisted in the collection of clinical data and processing of patient samples. F.C.L.C., C.W.H., J.T.H. and M.T.T. performed the pathology and associated figures. I.C.G.O., S.D.F., E.M.B., H.A.T. and M.A.D. wrote the manuscript. All authors reviewed and approved the manuscript.