LRR After an R0 or R1 Resection
STD, LOCOREGIONAL RECURRENCE, REGRESSION
Totally, 886/912 (97%) patients were included in the LRR analyses (Fig. Except for the mesorectum being more often breached in the EXP group, Table S4, Supplemental Digital Content 1, Univariate and Multivariate Cox Regression Analyses for Locoregional Recurrence Regarding Allocation Group, Distance From the Anal Verge and High-risk Factors at Baseline in Patients Who Underwent an R0 or an R1 ResectionBold values indicate statistical significance Test for interaction is In 61 patients, the distance from the anal verge was unknown.MRF indicates mesorectal fascia.The time from surgery to the detection of an LRR was 1.8 years (interquartile range: 1.2–2.6) in the EXP and 1.2 years (0.6–2.7) in the STD group (Regarding radiation technique, patients from the EXP group developed more often an LRR after 3D-CRT compared with the STD group (11.6% (37/320) vs. 6.0% (18/298); Univariate and Multivariate Cox Regression Analyses of Locoregional Recurrence Regarding Allocation Group and Pathologic Factors After Surgery in Patients Who Underwent an R0/R1 ResectionBold values indicate statistical significance Two patients did not undergo curative surgery; therefore, the initial number of patients included is 857 instead of 859.
In case the variable was unknown for a patient, the patient was set to missing. Therefore, the number of patients included in the multivariate analysis is considerably lower.Post-treatment restaging MRI data was available for 841/859 (97.9%) patients. In total, 632/841 (75.1%) patients were assessed as good responders (80.1% vs. 70.1% (Table S5, Supplemental Digital Content 1, 