2.1. Participants
tremor, rigidity, PD, bradykinesia, Parkinson, dyskinesias
MOVEMENT DISORDER, DISEASE, ASSOCIATED DISEASE, RECRUITMENT
A longitudinal crossover study, with a control group and an experimental group, was carried out. Participants with PD were recruited by consecutive non-probability sampling from September to October 2021. The inclusion criteria were: male and female patients diagnosed with PD, who, during the recruitment period, were attending the Neurology Department of the Burgos University Hospital, in any of the stages of severity of the disease, who had tremor and rigidity as a consequence of the disease in at least one of the UL. Patients whose tremor was a consequence of another associated disease according to the neurologist’s judgment or/and those with scores less than or equal to 26 on the Montreal cognitive assessment (MoCA) were excluded [The diagnosis of PD was established following the criteria established by the International Parkinson and Movement Disorder Society. The prerequisite for the application of these criteria is the presence of bradykinesia in combination with resting tremor, rigidity or both. In addition, at least two of the four supporting criteria had to be met: resting tremor, dramatic improvement with dopaminergic therapy, occurrence of dyskinesias as a consequence of levodopa or olfactory loss, or cardiac sympathetic denervation on myocardial scintigraphy [Each participant signed a written informed consent approved by the Clinical Research Ethics Committee of the Health Area of Burgos and Soria (Spain) with reference number CEIM-2119/2019 before participating in the present study (ClinicalTrials.gov test number: NCT04815382). Likewise, the study was conducted in accordance with the ethical principles set forth in the Declaration of Helsinki [