Discussion
tumor, radionecrosis
BRAIN METASTASES, TUMOR, TUMOR RECURRENCE, PROGRESSION
Retrospective studies have shown a potential benefit in the incidence of local tumor failure and radionecrosis of fSRS in the treatment of patients with brain metastases. However, prospective randomized studies are necessary to confirm these results. The primary endpoint of this trial is progression after (f)SRS according to RANO on a T1gd contrast MR. Progression can be either tumor recurrence or radionecrosis, or a mixture of both options, which is often hard to differentiate in clinical practice. Therefore, this composite primary endpoint is used.