Endpoints
ADVERSE EVENTS, SECONDARY
The primary endpoint in arm 1 was the ORR as assessed by the IRC according to RANO-HGG criteria. Secondary endpoints for arm 1 included ORR by RAPNO criteria per IRC; clinical benefit rate (CBR), progression-free survival (PFS), duration of response (DOR) and time to response (TTR), per IRC by RANO-HGG and RAPNO criteria; and safety and tolerability (primary endpoint in arm 2), assessed by the type, frequency and severity of adverse events (AEs) and laboratory abnormalities. Additional planned secondary endpoints not reported in this manuscript are described in detail in the full trial protocol (confidential information redacted) in the 