Conflict of interest
WL, HL
BX reports institutional research funding (investigator fees for this study to his institution) from F. Hoffmann-La Roche Ltd; and consultant/advisory roles for Novartis, Roche, and AstraZeneca. WL, QZ, QL, XW, HL, TS, YY, HZhe, and JF all report institutional research funding (investigator fees for this study) from F. Hoffmann-La Roche Ltd. HZhu and HM are employees of F. Hoffmann-La Roche Ltd. AS is an employee of Roche Products Limited. AK is an employee of Roche Products Limited and holds stock in F. Hoffmann-La Roche Ltd. All authors received research funding in the form of third-party writing assistance for this manuscript, provided by F. Hoffmann-La Roche Ltd.