Patients
Among the patients who volunteered to participate, 136 were selected, considering the inclusion criteria in a simple block randomization method performed by an independent person who was not involved in the trial. At the beginning of the trial, researchers explained the overview, purpose, trial process, probable side effects, how to withdraw, and any questions of patients. Patients were assured that participation in this trial was voluntary and they could withdraw from the trial at any time without any change in their right to regular treatment. Their participation in this trial and the data they provided would remain confidential; finally, they signed and accepted informed consent papers.