DNAm clocks
DNAm clock measures of aging are algorithms that estimate biological age, the state of an organism’s biology represented as the age at which that state would be typical in a reference population. The clocks we analyzed were developed to predict mortality risk. The age values computed by the clock algorithms correspond to the age at which predicted mortality risk would be approximately normal in the reference population used to develop the clock. We computed clock values based on versions of the clock algorithms developed from DNAm PCs (sometimes referred to as ‘PC clocks’)