Treatments
toxicity, death
DISEASE PROGRESSION
Eligible patients were randomly assigned (1:1) to 2 groups based on different administration schedules of MASCT-I in the first course, by the randomization specialist of Shanghai Canming Medical Technology Co., Ltd, using a central block randomization method. One MASCT-I course consisted of 3 DC subcutaneous injections and 3 active T cell infusions, with each T cell infusion being administered within 18–27 days after each DC injection (Additional file Fig. SIn both groups, 1–2 days after the first apheresis, patients received 1-h intravenous infusion of camrelizumab 200 mg every 3 weeks and oral apatinib 250 mg daily in 28-day cycles.To manage toxicity, treatment interruption of camrelizumab and treatment interruption and/or dose reduction of apatinib (250 mg every 2 days or 125 mg daily) were allowed (see Additional file The triple therapy was discontinued upon disease progression or recurrent, intolerable toxicity, withdrawal of consent, pregnancy, substantial noncompliance with study requirements, interruption of study treatment for more than 3 weeks, initiation of new anti-tumor treatment, loss to follow-up, or death. For patients not tolerate camrelizumab or apatinib, MASCT-I could be continued until disease progression or intolerance to MASCT-I. Patients who had radiological disease progression were permitted to continue study treatment if the investigator judged that the patients would benefit from and were tolerant to the continued treatment.