Conclusion
infection, HIV infection
INFECTION, HIV INFECTION
We identified two env epitopes that were targeted in some persons prior to infection. Reactivity to one epitope was associated with natural control of HIV infection and appeared to reduce VL via antibody-mediated suppression of viral replication. In contrast, reactivity to the other epitope was not present in HIV controllers and appeared to increase VL, possibly via ADE early in infection. These findings enhance our understanding of humoral mechanisms impacting controller status and VL and could inform the design of antibody-based approaches for HIV treatment.