Ethics approval and consent to participate
CLI
CRITICAL LIMB ISCHEMIA
This project under the title “Safety assessment for transplantation of adaptive human placental mesenchymal stem cells in patients with Critical limb ischemia (CLI): clinical trial phase 1” was approved by Ethical Committee of Shahid Beheshti University of Medical Sciences (IR.SBMU.REC.1400.025) (Approval date: 12/12/2021, consent to participate date: 19/04/2022). Written informed consent was obtained from each patient or the patient’s legally authorized surrogate before the conduct of study-specific procedures. All procedures were conducted in accordance with the relevant approved regulations, guidelines, and the Declaration of Helsinki. The trial was registered as IRCT20210221050446N1 at the Iranian Registry of clinical trials.