Introduction
Gastric cancer, malignancy
GASTRIC CANCER
Gastric cancer (GC) is the fifth most common malignancy worldwide. The highest incidence of GC exists in East Asian countries, especially in China and JapanIn the second-line therapy setting, ramucirumab was the only molecular-targeted drug in a global phase III clinical trialThymidylate synthase is a well-established target enzyme for GC therapy. The mechanism underlying 5FU resistance has been investigated with a focus on the level of the thymidylate synthase (TS) ternary complex formed with fluoro-deoxyuridine monophosphate (FdUMP)