Pyrimethamine induces HIV-1 transcription in vivo
To assess the potential of HIV-1 latency reversal in PLWH induced by pyrimethamine and VPA alone and in combination, we measured cell-associated unspliced (CA US) HIV-1 RNA by reverse transcription quantitative polymerase chain reaction (RT-qPCR) in CD4Addressing the primary end point of the study, we found that, overall, the absolute change in CA US HIV-1 RNA from baseline during the 6-week study period between the treatment groups was different (