Discussion
Obesity, CVDs, stroke, atherosclerosis, hyperlipidaemia, atherosclerotic, CVD, cardiovascular lesions, Behcet’s disease, Behcet’s illness, cardiac infarction, T2DM
CARDIAC INFARCTION, HYPERGLYCEMIA, OBESITY, CARDIOVASCULAR DISEASES, CVD, STROKE, DISEASE, HYPERLIPIDAEMIA, CHRONIC INFLAMMATORY DISEASE, REMISSION, INSULIN RESISTANCE, VOGT, REGRESSION, ATHEROSCLEROSIS, TYPE 2 DIABETES, ENDOTHELIAL DYSFUNCTION
Increased risk for cardiovascular lesions (CVD) in patients with pre-existing chronic inflammatory diseases at younger ages observed in some studies raised the assumption about endothelial dysfunction as a common initial lesion in the development of atherosclerosis [There are few studies examining S. irisin as a biomarker for diagnosing subclinical atherosclerosis in Behcet’s illness. In our study, we intended to investigate this topic.We did not find a significant relationship between serum irisin level and disease activity score, nor did we find a relationship between CIMT and disease activity score. The BSAS score of the included patients had a mean value of 5.6, and a range of 3 to 9 indicates that they are in remission and have been on treatment for more than six months. These results concur with Icli et al.’s findings [Subclinical atherosclerosis can begin early in life and be unnoticed until a cardiac infarction or stroke [Hyperglycemia and hyperlipidaemia are known to accelerate the atherosclerotic process by direct endothelial dysfunction augmenting cytokine release with increasing lipid peroxidation and causing oxidative damage [There were no documented cases of Q-T dispersion; therefore, the atherosclerotic changes in our patients are asymptomatic and a sufficient narrowing of coronaries may be required for symptoms to appear; our results agreed with [Obesity is a condition characterized by excessive fat buildup and is frequently accompanied with insulin resistance (IR), type 2 diabetes (T2DM), and cardiovascular diseases (CVDs) [The non-significant difference for ankle brachial pressure index between those of BMI 25 and those of BMI > 25 was cleared by the controlled blood glucose level, controlled blood lipid, and blood pressure in our patients.In the same instance, serum irisin levels did not differ significantly between those with a BMI 25 and those with a BMI > 25 (The regression analysis of factors affecting CIMT in a patient with Behcet’s disease revealed that the most influential factors on the disease were the patient’s age and ESR level. The patient’s age is one of the risk factors for atherosclerosis and can be determined by CIMT level [For characteristics that indicate subclinical atherosclerosis, male gender and decreasing S levels are predictive. Irisin, and decreasing ankle brachial pressure index agreed with Vogt et al. [Icli et al. [We also found a very strong correlation between CIMT, an indicator of subclinical atherosclerosis, and decreased irisin levels in BD patients.With a sensitivity of 94.30% and specificity of 93.33%, the declining level of S. irisin in patients can be utilized as a predictor of subclinical atherosclerosis. This finding agreed with Ankle Brachial Index Collaboration, 2008 [