Acknowledgements
We thank all the patients for participating in this study. This research was supported by the Guangdong Basic and Applied Basic Research Foundation [2020A1515010020 for Y.M., 2018A0303130243 and 2020A1515011464 for H.Z.] and the National Nature Science Foundation of China [82002409 for Y.M., 81872201 and 82073396 for H.Z., 81872499 for L.Z., and 82072558 for Y.Y.].