Study measures
DISEASE
Radiographs of the hands and feet obtained at Weeks 0, 24, 52 and 100 or at early discontinuation (if applicable) were scored in three separate reading sessions. The first reading session, comprising the primary radiographic endpoint analysis, included radiographs from Weeks 0 and 24 or at discontinuation if prior to Week 24; radiographs from Weeks 0, 24, and 52 or at discontinuation if between Weeks 24 and 52 were included in reading session 2; and radiographs from all time points including Week 100 were included in reading session 3 and are the subject of the current analyses. Radiographs were independently evaluated by two central readers with a third reader for adjudication [With a focus on peripheral joint activity, clinical response at Week 8 was assessed with the DAPSA, a validated composite measure commonly used in clinical practice, rather than other composite measures that include additional disease manifestations [