Antineoplastic therapy
COLD
Enrolled patients in the MMC group were provided with one dropper (dropper “A”) containing MMC at 0.4 mg/ml (0.04% solution) (Mitolem, Teva, Mexico) and other dropper (dropper “B”) containing saline water at 0.9%. Patients were instructed to apply one drop from the dropper A four times a day by 7 days and one drop from the dropper B by the subsequent 7 days. This cycle of drug and saline drops continued until a full resolution of the lesion was reached. Enrolled patients in the IFNα2b group were provided with two droppers (dropper “a” and “b”) containing solution IFNα2b at 1 million IU/mL (Injection Urifrón, Probiomed, Mexico). Patients in this group were instructed to instill one drop of dropper “a” for the first 7 days and one drop from the dropper “b” the following 7 days. Guidelines were given to all subjects in order to avoid contamination and preserve the cold chain (4ºC). Treatment with IFNα2b solution continued until a full resolution of the lesion was achieved. Treatment failure was defined as lack of response after 3 to 4 cycles of treatment with MMC or failure to achieve complete clinical resolution after up to 6 months of treatment with IFNα2b. Patients who failed to respond to any topical antineoplastic treatment underwent surgical excision.