Randomization sequence order.
Participants were randomly assigned in a 1:1:1:1:1:1 ratio to one of six study product application sequences (A-F), with the randomization configuration based on permuted blocks, to keep the allocation balanced. The randomization scheme, including enrollment of replacement participants, was generated and maintained by the MTN Statistical Data Manager Center (SCHARP), and it was configured in the Medidata Balance system prior to site activation. This allowed for participants being assigned to a randomized sequence by the system, only after site staff confirmed them as eligible and willing to enroll in the study.Each participant was followed for approximately 3.5 months and was expected to complete eight visits (including Screening and Enrollment visits). A regular visit was considered missed if the participant did not complete any part of the visit within the visit window. If an interim visit was completed to make up for the missed regular visit, then the missed regular visit was calculated as completed.