Introduction
OUD, overdose
DISORDER
Opioid use disorder (OUD) and overdose from opioids remain at epidemic levels in the USA despite the availability of effective treatments [Medications for OUD, including buprenorphine, methadone, and naltrexone, have established clinical efficacy and represent the standard of care in clinical practice. However, only approximately 11% of those who need treatment actually receive medications to treat their OUD condition [Buprenorphine extended-release (BUP-XR; RBP-6000; SUBLOCADEOpioid blockade, craving, withdrawal, and abstinence data from BUP-XR Phase 2 and Phase 3 studies in patients with moderate-to-severe OUD showed that buprenorphine plasma concentrations sustained at 2–3 ng/mL (corresponding to ≥ 70% brain 