Registration
MCI, dementia, cognitive impairment
DISEASES, CORTEX, ALZHEIMER
Chinese Clinical Trial Registry (ChiCTR2000039306).Rapid global population aging has led to a considerable increase in the number of people with dementia, which was estimated at 50 million by the World Alzheimer Report 2021 with an expected increase to 152 million by 2050. As diseases progress in older adults, significant resources are invested for treatment, with an estimated cost of care at US$1 trillion annually, which is expected to double by 2030 [Mild cognitive impairment (MCI) is a transitional period before the decline in cognitive function from normal ageing progresses to dementia. Approximately 10%-15% of people with a clinical diagnosis of MCI develop dementia each year [Evidence shows that active cognitive training may delay cognitive aging. Findings from randomised controlled trials [Building on the success of ACTIVE, multi-domain cognitive function training (MCFT) has been developed and tested. We used a brain plasticity-based adaptive cognitive training developed by LTPA (leisure time physical activity). This game-based training was designed to stimulate the cerebral cortex to improve cognitive functioning of patients. As such, older adults with MCI and mild dementia are a crucial population to intervene as evidence has shown that cognitive training can delay rapid cognitive function decline. Therefore, we conducted the first randomised controlled trial to explore and evaluate the efficacy of a short-term MCFT compared to passive information activities (PIA) training in older adults with MCI and mild dementia. We examined the cognitive function, working memory, attention, and coordination among older adults with MCI and mild dementia in the primary analyses. To examine the long-term effects of the MCFT and PIA on cognitive function, working memory, attention, and coordination, we evaluated the patients throughout a one year period.