Landscape of gene mutation, tumour mutational burden, microsatellite instability, and drug sensitivity analysis
tumour
TUMOUR, NONSENSE MUTATION, MICROSATELLITE INSTABILITY
The miscellaneous mutation was the most common variant classification in PCa, followed by the nonsense mutation (Fig. Gene mutation, tumour mutational burden and microsatellite instability, along with drug sensitivities analyses. (TMB and MSI, as one of the metrics to predict the benefit of immunotherapy, were utilized to guide clinical practice. To explore the relationship between them with the risk signature, the TMB and MSI score in both risk group were compared. It indicated that the high-risk group had higher TMB and MSI score (Bicalutamide and docetaxel were regarded to be the first-line drug in PCa treatment regimens. Thus, their half-maximal inhibitory concentration (IC