Background
death, Sepsis, intra-abdominal sepsis, inflammation, non-trauma, organ dysfunction, peritonitis, sepsis
SEPSIS, INFLAMMATION, EMERGENCY, PERITONITIS, SEPSIS
Sepsis is an increasing cause of death worldwide [Severe complicated intra-abdominal sepsis (SCIAS) represents a subset of IAS sepsis but is perhaps the most challenging clinical situation. Sartelli and the World Society of Emergency Surgery have defined IAS as severe when associated with organ dysfunction [Patients with SCIAS require early hemodynamic support, source control, and antimicrobial therapy [In patients with SCIAS, repeat laparotomy may be necessary to eliminate persistent peritonitis or new infectious foci [Pharmacologic approaches do not currently offer hope in SCIAS as studies of promising agents directed to combat post-infective inflammation have not shown evidence of significantly improved patient outcomes, and when suggested as having a role, have been incredibly expensive [The use of the OA for non-trauma general surgery is increasingly being reported in uncontrolled series as an option for patients with SCIAS [