Immunogenicity
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The immunogenicity results in PPS are shown in Immunogenicity of neutralizing antibody before and 28 days after two-dose vaccination (PPS).Seropositive indicates the GMT level ≥1:8. Seroconversion indicates the GMT changes from <1:8 to ≥1:8 after vaccination, or at least 4-fold increase after vaccination if baseline GMT is ≥1:8.* Adjusted GMT ratios were estimated by the geometric least-square mean estimates based on analysis of covariance (ANCOVA) model.In subgroup analyses by age, we found an increased trend of immune response with age decreasing, where the highest GMT at 28 days after two-dose vaccination was observed in participants aged 3-5 years [240.86 (95%CI: 222.78, 260.42)], followed by participants aged 6-11 years [155.12 (95%CI: 147.88, 162.71)] and 12-17 years [85.67 (95%CI: 81.06, 90.55)] (