Research design
NAFLD, napping, sleep-related traits, snoring, insomnia, impairment of liver function, steatosis
STEATOSIS
In this study, we see insomnia, daytime dozing, morningness, ease of getting up, sleep duration, daytime napping and snoring as sleep-related traits. Since the main traits of NAFLD are steatosis of the liver and impairment of liver function, we used the diagnosis of NAFLD, alanine transaminase levels, aspartate aminotransferase and percent liver fat as a description of NAFLD. In this study, we used a two-way Mendelian randomization approach to assess the causal relationship between sleep and NAFLD.First, we screened instrumental variables for MR analysis using sleep-related traits as “exposures” and NAFLD and related liver indicators as “outcomes”, and assessed heterogeneity using Cochran Q analysis. Heterogeneity was assessed using Cochran Q analysis, and finally sensitivity analysis was performed to verify the reliability of the causal results. Then, we performed a reverse MR examination, using the diagnosis of NAFLD and related liver indicators as the “exposure” and sleep-related traits as the “outcome”.