Subgroup analysis
septic, CRPA, carbapenem-resistant Acinetobacter, septic shock
PSEUDOMONAS AERUGINOSA, SEPTIC SHOCK, SECONDARY, SUPERINFECTION, INFECTION SITES
A total of 137 participants in the HD group and 144 participants in the LD group who survived for more than 72 h constituted the per-protocol population. The results are similar to those obtained in the intention-to-treat analysis; no difference was observed in 14-day clinical response, 14-day mortality, and 28-day mortality (Additional file Forest plots for subgroup analysis of infection sites and bacteria. CRE = carbapenem-resistant Enterobacteriaceae. CRAB = carbapenem-resistant Acinetobacter baumannii. CRPA = carbapenem-resistant Pseudomonas aeruginosa. Results for subgroup infected at other sites and subgroup infected with multiple bacteria are not applicable since a denominator value of zero is illegalSubgroup analysis of participants with septic shock showed that the primary and secondary outcomes did not differ markedly (Table Subgroup analysis results for patients with septic shockData are n (%) or median (IQR). n: sample size. HD: high dose. LD: low dose. RR: relative risk. HR: hazard ratio. RD: Risk Difference. *: Superinfection and original Bacterial persistence co-exist in 2 patients, so the sum of the parts of bacterial clearance is greater than 100% 