TTP treatment course
The fresh-frozen plasma (absolute plasma volume) replaced in the PP population by TPE over 3–11 days (median 5 days) ranged between 13.4 and 50.0 L (median 24.6 L) in the overall treatment period. Median normalized plasma volume, which is TPE days multiplied by the ratio of absolute plasma volume by estimated plasma volume, was 7.5. Seven participants in the PP population had an intensive care unit (ICU) admission during the study period; durations of ICU admission ranged from 2 to 8 (median 5) days in the overall study period. All 15 participants in the PP population were admitted to hospital; the duration of hospitalization was 10–56 days (median 37) in the overall study period.