Drug-drug interactions
DDIs
At baseline, identification of DDIs was modest in both control and intervention (7.8% for both arms, p = 0.532). After introduction of the CDM test, intervention significantly improved their ability to identify DDIs, increasing from 6.5 to 57.1% (p < 0.001) compared to contro which did not change (9.2–9.3%, p = 0.979).After identifying more DDIs, intervention was nearly twice as likely to make a clinical adjustment by typically either stopping the interacting medications or shifting to a different medication (32.5–64.9%, p < 0.001) compared to control (32.9–12.0%, p = 0.002).Here, the fixed effects model confirmed that intervention was 26.9x more likely to identify the DDI (95% C.I. 5.6-130.6) and 15.7x more likely to stop the interacting substance (95% C.I. 5.0–49.0).