4. Discussion
In this research project, the association between DNA methylation in the blood and the reduction of the BMI percentage with an intervention with two types of diets, a moderately high-protein diet (MHP) and a low-fat diet (LF), was studied in a Spanish population. Likewise, the CpG sites which basal methylation was associated with the reduction of the percentage of BMI after 4 months of dietary intervention were identified and then used to construct a total methylation score that was included in a model together with the two types of diets, and it adequately predicted the percentage of BMI loss.