4. Discussion
Anxiety, mood disorders, abdominal pain, IBS-D, IBS, weakness, Depression
CHRONIC DIARRHEA
The results obtained indicate that reducing the amount of TRP content in a low-FODMAP diet improves its effectiveness in the treatment of IBS-D patients. This effect is probably related to the decrease in serotonin secretion in the gastrointestinal tract. Serotonin as a neurotransmitter strongly stimulates motility and intestinal secretion, and its excess can be the cause of chronic diarrhea and abdominal pain [Our study was not a randomized controlled trial and has several limitations. TRP intake data was taken from nutritional information provided by subjects, who recorded the kind and amount of food they consumed. We assumed that the information provided was honest and reliable. It was the input for the food calculator that gave data on the TRP content in the meals the subject had. In addition, mood disorders were diagnosed of the basis on the Hamilton Anxiety and Depression Scale and no other examination was done. Another weakness of the study is the non-blinded nature of the experimental design however modification of the diet and its use took place in close cooperation with the patients, therefore its blinding was impossible.The results may also inspire further research to determine of impact the optimal intake of TRP on the somatic and mental state of the patients with different types of IBS. Furthermore, the results did not challenge the precision of the low FODMAP diet in the treatment of IBS patients, but indicate the desirability of modulating the intake of TRP. However, the results inspire further research to determine the effect of optimal TRP use on the somatic and mental state of patients with different types of IBS. 