3. Discussion
menopausal hypoestrogenism
PBM, through the use of LEDs and LASERs, has shown good results in the treatment of wounds, increasing the formation of fibroblast cells, collagen synthesis, and reduction and control of inflammatory cells with a consequent increase in tissue formation.In addition, the instruments used to evaluate the results are often subjective, highlighting the need for additional evaluations through more precise methodologies. This work described a randomized, controlled, double-blind clinical trial protocol based on the comparison of a treatment to be performed in 3 groups for 4 weeks: one group will receive the application of the red LED mask 3 times a week, another group will receive treatment 2 times a week and the control group will perform the simulated application of the LED mask twice a week. To increase participant compliance, a neutral face cream formulation was donated to be used by all patients at night during treatment.The sample should be as homogeneous as possible to minimize individual biases, hence the importance of delimiting the age of participants between 45 and 60 years old, Glogau from 2 to 4, and who are in menopause. It is known that menopausal hypoestrogenism leads to changes in skin metabolism, such as changes in collagen fibers and reduced water content, favoring aging.Other important issues are that this protocol proposes a double-blind study and the randomization will be performed in blocks.Self-assessment has become an important tool to evaluate the results of aesthetic procedures,It is known that most studies that evaluate the face are based on subjective measures (patient satisfaction and photos) or using skin biopsy.In summary, this clinical trial aims to contribute to clarifying the role of PBM application frequency in improving the appearance of the facial skin of menopausal women using qualitative and quantitative methodologies.