Introduction
RVF, VIRUS, ZOONOSIS, RIFT VALLEY FEVER
Rift Valley fever (RVF) is a mosquito-borne viral zoonosis that primarily affects domestic livestock (sheep, goats, cattle) and humans in Africa and the Arabian Peninsula.Natural exposure to RVF generates long-lived protective neutralising antibody (nAb) in both humans and livestock, with a modest declining of titres over many years in the absence of re-exposure.Two RVF vaccine candidates have previously been evaluated in humans. The first is an inactivated vaccine, TSI-GSD-200, which had a good safety profile but even after an initial three-dose regime, approximately 10% of vaccinees failed to seroconvert.ChAdOx1 RVF has shown remarkable safety, immunogenicity and 100% efficacy against wild-type RVF virus challenge in sheep, goats, and cattle in Kenya.