Conflicts of interest
Yousuke Nakai receives research fund from Taiho Pharma. Hiroyuki Isayama receives research fund from Yakult Honsha Co., Ltd. MU receives lecture fees, honoraria, or other fees from Yakult Honsha Co., Ltd. and research fund from Yakult Honsha Co., Ltd. Tatsuya Ioka receives lecture fees, honoraria, or other fees from Taiho Pharma and Ono pharmaceutical Co., Ltd. Masashi Kanai receives profit from shares of Therabiopharma Inc. and lecture fees, honoraria, or other fees from Chugai Pharmaceutical Co., Ltd. and research fund from Molecular health.