Patients
embolic acute, embolic stroke, ischemic stroke
TRANSIENT ISCHEMIC ATTACK, EMBOLIC STROKE, ISCHEMIC STROKE
The trial included adult (≥18 years) patients who experienced a clinical episode that, in the opinion of the treatment team, included an embolic acute neurovascular episode (eg, ischemic stroke or transient ischemic attack) on the differential diagnosis prompting patient referral for a TTE with agitated saline bubble contrast as part of routine clinical care. Specific subject inclusion and exclusion criteria are included below.Subjects met all the following inclusion criteria to be enrolled in the study:18 years of age or olderPresentation with a clinical condition characterized by neurological signs and symptoms that, in the opinion of the investigator, include embolic stroke or transient ischemic attack in the differential diagnosisScheduled for TTE study with agitated saline contrast (bubble study) within ±30 days of informed consentAbility to successfully perform a Valsalva maneuver.Signed informed consentAbility to comply with the protocolSubjects were not enrolled in the study if any of the exclusion criteria were met:History of RLS/PFO closurePregnancy or lactation at the time of studyHistory of partial or full craniotomy/craniectomy within the past 6 monthsPresence of a physical limitation preventing TCD/Headmount placement