Methods
death, non-acute promyelocytic leukemia
DISEASE, REGRESSION, EVENT, REMISSION
Patients between 18 and 64 years of age, registered between April 2005 and September 2020 with non-acute promyelocytic leukemia, who attained complete remission after intensive induction and received at least one consolidation cycle with intermediate (IDAC) or high-dose cytarabine (HiDAC), defined as 1–1.5 g/mPatient selection for the present analysis. Overall survival (OS) was defined as time from diagnosis to death from any cause. If no death was observed, OS time was censored on date of last follow-up. Relapse-free survival (RFS) was defined as time from date of first complete remission until relapse or death from any cause, whichever occurred first. If no relapse or death was observed, RFS time was censored on date of last follow-up. To assess the impact of allogeneic hematopoietic cell transplantation in sensitivity analyses, we also calculated OS and RFS with censoring on the date of allogeneic hematopoietic cell transplantation, if this occurred before the first event of interest. For estimation of adjusted survival of IDAC- and HiDAC-treated patients according to Kaplan–Meier propensity score weights for the average treatment effect were estimated, because both groups differed significantly in some important characteristics (age, sex, cytogenetic risk group, ECOG performance status, disease status, HCT-CI, number of induction cycles). A sufficient balance was reached with these propensity score weights. To assess the differential impact of IDAC versus HiDAC, multivariable Cox regression models with interactions of IDAC/HiDAC and the variable of interest were fitted. These models were adjusted for the parameters also used for estimation of the propensity score weights. Missing values in variables were imputed with simple imputation methods, if they were used for calculation of the propensity score or for adjustment of the multiple regression models. Missing values in categorical variables were imputed with the most frequent category of the observed values, missing values in continuous variables were imputed with the median of the observed values.