Trial Procedures and Interventions
low systolic blood pressure
The study design is presented in eFigure 1 in Lower starting doses were used for patients with low systolic blood pressure (SBP; ≥100 mm and <110 mm Hg) or on low or no dose of angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker at the baseline visit. Full details of the medication manufacture, randomization, blinding, allocation concealment, and titration protocol are in eMethods 2 and eTable 2 in 