Comparing low dose vs high dose
cold sweats, sweats, muscle cramps, ’
To contrast the effect of low-dose tamoxifen (2.5 and 5 mg) to high-dose (10 and 20 mg), we compared the sum of mean Likert score change (from baseline to end of treatment) in the five side effects (‘hot flashes’, ‘night sweats’, ‘cold sweats’, ‘vaginal discharge’ and ‘muscle cramps’) significantly associated with 20 mg tamoxifen in both premenopausal and postmenopausal women. We found a significant difference in the severity of side effects in premenopausal, but not in postmenopausal women. Premenopausal women at low-dose tamoxifen reported 34% less severity of side effects compared to women in the high-dose group (sum of mean Likert score change: 1.61 (95% CI: 1.17–2.04) versus 2.47 (95% CI: 1.98–2.96)) (Fig. 