Study design and study sample
We conducted a multicenter RCT using a stepped wedge design, the details of which have been reported previously (The stepped wedge cluster randomized design involved sequential transition of the participating hospitals in a randomized order. Over a period of 16 months, 13 Dutch hospitals (3 academic and 10 nonacademic) consecutively switched from care as usual (the control group) to an intervention period (see All patients provided written informed consent upon inclusion. The study was approved by the institutional review board and medical ethical committee of the Amsterdam University Medical Centers (UMC), location Vrije Univeristeit medical center (VUmc), as well as by the review boards of all participating centers. The study was registered in the Netherlands trial register NL7897.