Introduction
inflammation, PWH, CVD, HIV (PWH
CVD, INFLAMMATION, CARDIOVASCULAR DISEASE
Persons with HIV (PWH) have an increased risk of cardiovascular disease (CVD) compared to HIV-seronegative individuals (SN).Despite the critical role that inflammation plays in HIV outcomes such as CVD, the role of lipid mediators of inflammation (Bioactive lipid families. Illustration summarizing the bioactive mediator families evaluated in the present study together with their parent fatty acid and overall classification of their biological activities.It is now appreciated that lipid mediators mainly from the omega-3 essential fatty acids eicosapentaenoic acid, n−3 docosapentaenoic acid and docosahexaenoic acid and termed as specialized pro-resolving mediators (SPM) are central to the reprogramming of immune responses to limit inflammation.Studies investigating the mechanisms of aspirin in the general population, where it used to reduce CVD risk, demonstrate that, To address some of the gaps in knowledge related to the role of lipid mediators (and their biosynthetic pathways) and in particular SPM in PWH, we compared levels of lipid mediators of inflammation in peripheral blood of PWH on suppressive ART and SN from well-characterized study populations.