Conclusions
RECRUITMENT
The current study did not demonstrate a significant benefit of adding MBCT to SPD to support discontinuation in general practice. Considering the low engagement in this specific context, this should not be taken as a generalized negative recommendation against MBCT to support ADM discontinuation, but it does raise some important questions about recruitment strategies, shared decision making, and (alternative) methods of treatment delivery.Given the apparent difficulties with tapering ADM, it seems essential that those who prescribe them do so very carefully, preferably for a restricted period of time, revising patients regularly, and taking an active role in informing the patient about possible tapering (ideally already before initiation of ADM use), and supporting the process of discontinuation. The mental health nurse might play a role in the latter. In a recent scoping review, deprescribing intervention activities included identification of appropriate patients for deprescribing, patient education, GP education, and development and use of a tapering schedule [