Variation between treatment arms
parasitaemia, anorexia, fever
REGRESSION, ANOREXIA
At the study site in Arba Minch, Ethiopia, anorexia between day 3 and day 13 was reported in 87.3% (62/71) of patients receiving placebo, 76.2% (112/147) of patients receiving low dose primaquine, and 83.3% (120/144) patients receiving high dose primaquine. In contrast, in Krong Pa, Vietnam, none (0/21) of the patients receiving placebo or low dose primaquine (0/43) reported anorexia compared with 7.3% (3/41) receiving high dose primaquine. In separate multivariable analyses for the presence of each symptom between day 3 and day 13, after adjusting for treatment category, age, sex, baseline parasitaemia and fever at presentation, the differences in symptom reporting were greater between study sites than between treatment arms within the same study site (Fig. Covariate-adjusted estimate (95% CI) of proportion of patients reporting symptoms at least once between day 3 and day 13 by treatment arm Legend: PQ – primaquine; PQ14 – 14-day course of primaquine; PQ7 – 7-day course of primaquine; Covariate-adjusted site-specific estimated proportions for each treatment arm were generated from logistic regression models adjusted for treatment arm, age, sex, day 0 parasite density and day 0 fever, with all confounders (except treatment arm) set at mean/prevalence values for all trial patients