Introduction
stroke, acute ischemic stroke, AIS
STROKE
To date, there is a paucity of effective neuroprotective treatments for acute ischemic stroke (AIS), other than reperfusion therapy such as intravenous thrombolysis and mechanical thrombectomy, which is limited by a strict therapeutic time window and requirement for a highly developed stroke system of careIn theory, compared with the supine or lying-flat position, the steeper head-down position (i.e., fully supine with TrendelenburgIn this work, we undertook the prospective, multicenter, randomized, open-label, blinded-endpoint trial to explore the effect of HDP, initiated within 24 h of symptom onset, in moderate AIS patients with LAA who were not eligible for intravenous thrombolysis or endovascular therapy.