Data availability
De-identified data can be made available under restricted access from the corresponding author (Ravi.Retnakaran@SinaiHealth.ca), for academic purposes, subject to a material transfer agreement and approval of the Mount Sinai Hospital Research Ethics Board. Individual participant data that underlie the results reported in this article can be made available by this mechanism, after de-identification, to achieve the aims in the approved proposal. Access is controlled in this way because of the clinical nature of the data. The study protocol can also be made available in this way. This data access mechanism will be available beginning 9 months and ending 36 months following publication of this article. We will attempt to respond to requests within 3 months, pending Research Ethics Board capacity to do so within this time frame. Source data for figures have been provided with this paper. 