Introduction
wart
HYPERSENSITIVITY RESPONSE, WART, RECURRENCE, HPV INFECTION, WARTS, MUMPS, PLANE WARTS
Two therapeutic options are used for treatment of warts: the first is the destructive method, like chemical cautery, cryotherapy, electrocauterization, surgical excision, and laser ablation, which are painful and with common recurrence [Intralesional (IL) immunotherapy with different skin test antigens like Candida, mumps, or trichophyton antigen induce a delayed type of hypersensitivity response to various antigens and the wart tissue leading to production of Th1 cytokines which activate cytotoxic and natural killer cells to eradicate HPV infection. This clears not only the local warts but also distant warts [Zinc is important for immune regulation as it stimulates the leucocytes and natural killer cells, zinc was found to be deficient in patients with multiple or recurrent warts [Different concentrations of Candida antigen (1/100 and 1/1000) and zinc sulphate were not previously compared regarding their efficacy in treatment of warts. This study compared the efficacy and safety of intralesional (IL)injection of different concentrations of Candida Ag (1/100 and 1/1000) and zinc sulfate 2% in patients with multiple palmar, plantar, and plane warts.