Interventions
HED
CON received standard care and was encouraged to maintain habitual physical activity and dietary habits throughout the study. DCON received standard care and dietary intervention. MED received standard care, dietary intervention and an exercise intervention with two aerobic training sessions per week and one combined aerobic and resistance training session per week, totaling 150–165 min of exercise training per week. HED received the standard care and dietary interventions as described above but had twice as much exercise as MED, with a total of four aerobic training sessions per week and two combined aerobic and resistance training sessions per week, totaling 300–330 min of exercise training per week.