Prospective cohort study
allergic sensitisation, asthma, wheeze
DISEASE, ASTHMA

Secondary outcomesThe sensitivity and specificity of new VOC sensing techniques (e.g. SIFT-MS and VOC sensors) for a diagnosis of asthma or transient wheeze in preschool children. Assessment at the start of the study in relation to the current gold standard in breath research (GC–MS) and at the age of 6 years in relation to the final diagnosis.Identification of other potential discriminating biological parameters (such as allergic sensitisation, immunological markers, epigenetics, transcriptomics, microbiome) between asthma, transient wheeze, and healthy controls, and the subsequent identification of underlying disease pathways and relation to the discriminative VOCs in exhaled breath. Assessment of data collected at the start of the study and at the end in relation to the final diagnosis at the age of 6 years.Identification of discriminative exhaled VOCs (based on GC-