1. Introduction
death, traumatic brain injury, traumas, posttraumatic hyperinflammation, trauma
UTI
Injuries caused by trauma remain one of the most common causes of death in the world, especially emergency severe multiple traumas combined with traumatic brain injury.Ulinastatin (UTI) is a serine protease inhibitor with a molecular weight of 67,000 that is purified from human urine. The primary pharmacological activities of this compound were anti-inflammatory, immunoregulatory, and organ protection.However, because of the unique nature of emergency severe multiple trauma patients and the lack of evidence-based medical studies with large sample sizes, the efficacy of UTI treatment remains unclear. Thus, the present study aimed to test the hypothesis that the administration of UTI would improve the outcome and alleviate posttraumatic hyperinflammation after severe multiple traumas.