1. Introduction
muscle mass, impaired muscle oxidative, inflammation, muscle dysfunction, COPD
COPD, OXIDATIVE STRESS, INFLAMMATION, CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Chronic obstructive pulmonary disease (COPD) patients manifest muscle dysfunction and impaired muscle oxidative capacity, which result in reduced exercise capacity and poor health status. This study examined the effects of 12-week eccentric (ECC) and concentric (CONC) cycling training on plasma markers of cardiometabolic health, oxidative stress, and inflammation in COPD patients. A randomized trial in which moderate COPD was allocated to ECC (Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation associated with inflammation of the airway [Several studies have shown that exercise training is the cornerstone of pulmonary rehabilitation as it markedly improves functional performance, muscle mass, and exercise capacity in COPD patients [Interestingly, exercise training in COPD patients has been shown to produce positive [Thus, this study aimed to examine the effects of 12 weeks of eccentric (ECC) and conventional concentric (CONC) cycling training on markers of oxidative stress, inflammation, and cardiometabolic health in COPD patients measured at rest. Furthermore, as oxidative stress could be induced by acute exercise, we compared the changes in oxidative stress markers following a standardized submaximal exercise between ECC and CONC, before and after training in COPD patients. 