Author contributions
AS led the study as chief investigator. AS, CG, JT, and KF obtained funding for the research. AS, PL, CG, JT, JW, JG, and KF contributed to the design of the main REACT Study. JW led the coordination of the REACT study as the trial manager. PL, MW, CG, JW, and AS conceptualised the study design of this article. PL designed the REACT exercise protocol and wrote the original draught with critical input from all other authors. JW, JK, JB, and SM were involved in the collection and processing of data. MW performed formal data analysis. All authors contributed to the article and approved the submitted version.