Author contributions
MR, RNay
VM, RNag, and NM take responsibility for the integrity of the data and the accuracy of the data analysis and drafting of the manuscript. RNag, NM, and VM contributed to concept and design. SP, SS, AG, MR, RNay, and VM contributed in acquisition, analysis, or interpretation of data. NM, RNag, MK, and HN did critical revision of the manuscript for important intellectual content. VM contributed in statistical analysis. VM, NM, and RNag obtained funding and contributed in administrative, technical, or material support. All authors contributed to the article and approved the submitted version.We thank the patients who participated in this study, their families, and all participating investigators as well as their clinical and nursing staff.