Introduction
obesity, death, ischemia/reperfusion, Stroke, stroke, stroke-related brain damage, ischemic stroke
OBESITY, STROKE, HYPERLIPIDEMIA, STROKE, INFLAMMATION, ABDOMINAL OBESITY, ISCHEMIC STROKE, EVENTS, OXIDATIVE STRESS, HYPERTENSION, PATHOGENESIS
Stroke is a leading cause of death worldwide [Following a stroke, a cascade of molecular events including increased extracellular glutamate concentration, increased intracellular calcium levels, and oxidative stress are initiated [Stroke causes changes in the patients’ lifestyle and ultimately affects their quality of life [Curcumin has many pharmacological activities that are relevant to the treatment of stroke [Studies showed that apoptosis during ischemia/reperfusion plays an important role in stroke-related brain damage [Abdominal obesity, hyperlipidemia, hypertension, inflammation, and oxidative stress are considered risk factors for ischemic stroke; treatment of them is mandatory for both prevention of stroke and reducing the risk of mortality in patients with ischemic stroke [Curcumin, as a strong anti-inflammatory agent, inhibits the activation of NF-KB and ensuing expression of various inflammatory cytokines, including TNF-α, IL-8, IL-6, and IL- 1, and reduces the expression of CRP and inflammatory enzymes such as cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS) [Curcumin reduces triglycerides by decreasing the activity of lipoprotein lipase [Curcumin regulates the Janus Kinase enzyme (JNK), which has been shown to play an essential role in the pathogenesis of obesity [Despite its high therapeutic potential, curcumin is limited for medical purposes due to its low aqueous solubility, low bioavailability, and rapid degradation [It seems that curcumin has several unique properties to improve the health condition of patients with ischemic stroke. However, to the best of our knowledge, there has been no clinical trial investigating the efficacy of curcumin on these patients to date. Thus, the purpose of this study was to investigate the effects of supplementation with curcumin-piperine combination in patients with ischemic stroke in the rehabilitation stage.