3.2. Immune Activation Induced by Mitazalimab Is Detectable in Blood Transcriptome
Next, the transcriptomic changes induced by mitazalimab treatment were investigated. To this end, the patient cohorts treated with 600 µg/kg or 900 µg/kg mitazalimab were further studied, as no evident changes were seen at 75 µg/kg or 200 µg/kg. In DGE analysis between C1D1 and C1D2, the 600 µg/kg and 900 µg/kg cohorts had 1027 and 485 DEGs, respectively. However, no DEGs were found between the 600 µg/kg and 900 µg/kg cohorts at C1D2 (Of the DEGs in the two dose cohorts, 392 DEGs were in common for both dosing cohorts (To further evaluate the biological effects of mitazalimab, we investigated a set of well-defined immune transcripts. After treatment with either 600 µg/kg or 900 µg/kg, it was found that the genes related to T cells (The potential influence of pretreatment with corticosteroids on the effects of mitazalimab was investigated in patients receiving 600 µg/kg mitazalimab with (