Interview-based Clinical Outcome Assessments
depression, hypo/mania, syndromal
RECURRENCES
Independent evaluators who were unaware of treatment assignments conducted interviews with the youth and at least one parent at the time of randomization (covering the 4 prior months), every 4 months in year 1, and then every 6 months for up to 4 years (median follow-up of 98 weeks, range 0-255 weeks). To quantify the severity and polarity of symptoms at each follow-up interview, evaluators administered the YMRS (hypo/mania) and CDRS-R (depression) interviews covering the prior 1- and 2-week intervals, respectively. Next, evaluators rated each week of the preceding 4- or 6-month interval using the Adolescent Longitudinal Interval Follow-up Evaluation (A-LIFE) Psychiatric Status Ratings (PSRs) [PSR data were used to define the time to recovery from pretreatment symptoms (all PSR scales ≤ 2 (mildly symptomatic) for ≥ 8 consecutive weeks) and among those who recovered during follow-up, time to new mood episodes or recurrences (≥ 2 weeks with PSR depression ratings of 4 (syndromal, moderate severity) or higher, or ≥ 1 week PSR hypo/mania ratings of 5 (syndromal) or higher). Interrater reliabilities for weekly depression and hypo/mania PSRs were 0.88-0.99 (intraclass rs) across raters at three sites.