Intervention
Patients were randomized on a 1:1 basis to receive either standard of care (SOC) or standard of care plus hemoadsorption (HA). Randomization sequence was generated using the Excel (Microsoft, Redmond, USA) Rand () function with a 1:1 ratio and permuted blocks of variable sizes. The allocation group was stored within numbered sealed envelopes.All patients were managed according to local protocol and international guidelines. This included 24 h of targeted temperature management with a central temperature target at 35–36 °C, hemodynamic management targeting a mean arterial pressure > 70 mmHg, glycemic control, avoidance of hyperoxia (PaOFor patients allocated to the intervention group, HA was performed as a stand-alone therapy, using a CytoSorb