Levodopa and naltrexone influence relief reinforcement learning in the wheel of fortune task
pain
To investigate whether pain relief gained in active relief seeking was associated with an impact on choice related to reinforcement learning, one of the 2 choices in the wheel of fortune was associated with a fixed 75% chance of winning pain relief (Participants selected the color of the wheel of fortune associated with a higher likelihood for winning relief in 64% (SD = 28%) of trials in the placebo condition, consistent with a reinforcement learning effect. Thus, participants chose the color associated with the higher likelihood for winning above chance (χHowever, participants’ performance significantly differed between the placebo and the drug conditions (main effect of ‘drug’: 