Discussion
blood loss, postoperative pain, arthroplasty, DVT
BLOOD LOSS, COMPLICATIONS, DVT
The most important finding of this study was that the intravenous administration of TXA reduced perioperative total blood loss in MOWDTO without increasing the incidence of DVT.This is the first randomized controlled study to examine the effectiveness of intravenous TXA administration in MOWDTO, which was developed as a modification of MOWHTO.Osteotomies around the knee are widely accepted surgical options for osteoarthritic knees and there are several modified procedures to cope with potential shortcomings of MOWHTO. However, some authors have reported that approximately 5 to 7% of patients who underwent MOWHTO experienced complications associated with wound problems [As for potential risks of the use of TXA, previous studies in patients undergoing total joint arthroplasty have shown that TXA administration is not associated with increased incidence of DVT and PE [Regarding the effectiveness of TXA administrations in decreasing postoperative pain, several reports have concluded that it could relieve postoperative pain [There are several limitations in this study. First, the surgical team and anesthesiologists were not blinded. On the other hand, the surgical approach was consistent in both groups, and the total blood loss as a primary outcome could not have been biased by the observer. Second, the control group did not receive placebo. Finally, in the present study, the obtained data are limited to only short-term outcomes and the effects of TXA administration on the clinical outcome or patient satisfaction were not subjected to analysis.