Costing and cost-effectiveness analysis
TB
The endpoint of interest for the costing analysis will be a continuous outcome of household costs from enrolment until treatment completion/discontinuation, and health system costs through the course of the study period. We will calculate the mean difference in costs, comparing the intervention to the SOC arms.The unit cost of diagnosis and treatment will be calculated from measured costs from the patient and health system perspectives. The outcome of interest will be the sum of patient plus health system costs, expressed as unit costs (e.g., cost per test, cost per TB treatment), under the intervention and under the standard of care. This outcome will not be subject to a formal statistical hypothesis test.The modeled incremental cost-effectiveness ratio will be calculated from cost and effectiveness outcomes, including both patient and health system perspectives. The outcome of interest here will be the incremental cost per DALY (disability-adjusted life year) averted. This outcome will not be subject to a formal statistical hypothesis test.All analysis will be conducted using R version 4.1.1 (R Foundation for Statistical Computing, Vienna, Austria) [