Introduction
immune-mediated disease of the oral mucosa, tumor necrosis, OLLs, TNF-α, GVHD, OLP
TUMOR NECROSIS, GRAFT VERSUS HOST DISEASE, ORAL LICHEN PLANUS, LYMPHOCYTIC INFILTRATION, GVHD
Oral lichen planus (OLP) is a relatively common chronic mucocutaneous inflammatory immune-mediated disease of the oral mucosa [On the other hand, oral lichenoid lesions (OLLs) are a term used to identify conditions that are clinically and histopathologically similar to OLP but with identifiable, either local or systemic causes such as numerous medications, various dental materials (mercury-containing amalgam restorations), and graft versus host disease (GVHD). Compared to the traditional signs of OLP, OLLs tend to be unilateral with histological examination showing more diffuse lymphocytic infiltration with more eosinophils, plasma cells, and colloid bodies. In addition, it resolves once the cause is removed [Multiple factors [In OLP lesions, ROS exacerbate inflammatory conditions linked to immunological pathways through the activation of NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells), a protein complex that regulates proinflammatory gene transcription, such as interleukin 2 (IL-2), tumor necrosis factor-alpha (TNF-α), MHC class 1 gene, and IL-2 receptor gene [A variety of treatments are used in the management of OLP [Co enzyme Q10 is a lipid-soluble endogenous antioxidant compound due to its ability to scavenge free radicals such as superoxide anion (O2•), hydrogen peroxide (H2O2) and hydroxyl radical (OH•) [