Pharmacokinetics (PK)
PK blood samples were collected predose, at 1, 2, 4, 8, and 10 h post dose on day 1 and day 10 and at 24 h and 48 h after the last dose of JNJ-54175446. The maximum plasma concentration (Cmax), minimum observed plasma concentration (Cmin) and the area under the plasma concentration-time curve (AUCτ) was measured during dosing interval (τ). Just prior to the beginning or at the end of a dosing interval of any dose other than the first dose, the observed plasma concentration (Ctrough) was determined. Average plasma concentration (Cavg) was measured at steady state over the dosing interval and time to reach the maximum plasma concentration (tmax) was measured.