Ethics approval and consent to participate
CMO
The Research Ethics Committee of the Radboud University Medical Centre in Nijmegen (CMO region Arnhem-Nijmegen) judged the study not to be subject to the Medical Research Involving Human Subjects Act, reference number 2021–8221. Additionally, the study was approved by the TNO Institutional Review Board (TNO-IRB, Healthy Living), reference number 2021–054. The study is conducted in accordance with guidelines and regulations of the Declaration of Helsinki. Written informed consent will be obtained from all participants in the study. The study is entered in the ISCRTN registry, reference ISRCTN16929184 on 29/03/2022. Any important modifications to the protocol will be reported to the CMO, TNO-IRB, ISCRTN and the funding body (ZonMw).