Funding
Open Access funding enabled and organized by Projekt DEAL. The RICH Trial was funded by an unrestricted grant by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation; ZA428/10-1 to AZ). The current work was supported by a rotational position of Dr. von Groote in the Clinical Research Unit 342 (KFO 342), funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation; ZA428/1-1 to AZ) and by the Deutsche Forschungsgemeinschaft (DFG) project number 493624047. Supplies for the measurement of the Proenkephalin A 119–159 biomarker were provided free of charge by SphingoTec GmbH.