Exposure–efficacy analysis
REGRESSION
Patients with at least one postdose value and the appropriate PK exposure information for bosutinib were included in the exposure‐response analysis of key efficacy outcomes, which were cumulative MMR and cumulative CCyR (any on‐treatment response). Exposure‐response analysis was performed using binominal logistic regression to assess the relationships between key efficacy outcomes and specific metrics of bosutinib exposure (linear and log‐transformed) based on lowest deviance value (cumulative area under the concentration–time curve up to time to initial response [cAUC], average concentration calculated as the ratio of cAUC over the respective timeframe [