Discussion
overfeeding of fats, prediabetes
ADVERSE EFFECTS, SAID, INSULIN SENSITIVITY, PREDIABETES
The aim of this randomized controlled trial was to examine the effects of long-term almond consumption on insulin sensitivity and glucose metabolism in males and females with prediabetes. So far, the hypoglycaemic effects of almonds are inconsistent [A major question is how the inconsistent results regarding possible hypoglycaemic effects of almonds as presented in the literature [Besides those two options, we postulated that changes in body weight could be an explanation for the inconsistent results. In line with Lovejoy et alAs the adverse effects of long-term almond consumption cannot only be ascribed to body weight, we need to examine other possible explanations. Considering the nutrient composition of almonds, it is surprising that we found these adverse effects on glucose metabolism. Theoretically, it could relate to the overfeeding of fats due to the almond consumption, resulting in fat accumulation in the liver [As said, already a number of studies could not show a beneficial effect of almonds on insulin sensitivity and glucose metabolism. To the best of our knowledge, we are the first study that showed adverse effects upon almond consumption. Though unexpected, findings are consistent between the different approaches used, In conclusion, our findings suggest that long-term almond consumption may negatively affect insulin sensitivity and glucose metabolism in subjects with prediabetes. These adverse effects could not be explained by the observed increase in body weight alone. Nevertheless, almonds have been consistently shown to positively affect other cardiometabolic risk factors [