Ethics approval and consent to participate
The consent-form, as well as the complete EVA-Tyrol-Study protocol, has been approved by the local ethics-committee Innsbruck (AN2015–0005 345/4.13). The study was conducted according to the guidelines of good clinical practice (GCP) and the declaration of Helsinki.Informed consent was approved and signed by all participants and additionally, if the participants were aged under 18 years, by the legal representative (parents/guardians).