References
AD, Dementia
INFLAMMATION, OXIDATIVE STRESS
Clinical flowchart of AD patient enrollment.Serum BDNF levels were analyzed at baseline and after 12 weeks of probiotic intervention in active control and treatment groups of AD patients. BDNF = brain-derived neurotrophic factor; * Probiotic supplements modulated inflammation, cortisol, and oxidative stress in AD patients. Serum levels of (The ORs with 95% confidence intervals (95% CI) for the active control or treatment group in a 12-week intervention with probiotic supplements on AD assessment scales have been determined. These ORs with 95% CIs were used as dichotomous variables to assess whether there was a deterioration when comparing scores between before and after the intervention. ORs = odds ratios; ADAS-Cog = Alzheimer’s Disease Assessment Scale-Cognitive Subscale; MMSE = Mini-Mental State Examination; ADL = Activities of Daily Living; CDR = Clinical Dementia Rating.Gut microbiota diversity, the top 7 phyla, and altered genera after a 12-week probiotic intervention in AD patients were analyzed. (The examined age, gender, and baseline and endpoint cognitive functions of AD patients.Data are expressed as mean ± standard deviation. 