Data sources and statistical methods
NSCLC, SCLC, death, cancer, lung cancer, tumors, Cancer
SCLC, CANCER, LUNG CANCER, SMALL CELL LUNG CANCER, NSCLC, TUMORS, CANCER
The study cohort is summarized in Fig. We consider non–small cell lung cancers (NSCLC) with stage at diagnosis available. Within the intervention arm (screening), 1634 NSCLC were detected, while 1547 were diagnosed in the control arm (no screening). NSCLC in the intervention arm were categorized into one of four groups for detection method: Screen (detected by CXR at the annual screening exams), Interval (detected between scheduled screening exams or up to 1 year after final screening), Never (participant was randomized to intervention but never participated in any screenings), and Post (cancer diagnosed more than 1 year after final screening). Data were obtained from the Cancer Data Access System (CDAS) under a material transfer agreement and IRB approved protocol (CDAS project PLCO-808).For this study, the primary analyses (4-Year Cohort) was restricted to patients diagnosed during the first 4 years (screening period + 1 year follow-up) of the randomized trial when annual CXR was offered in the intervention arm. We merge together patients whose tumors were detected in the Never and Post group into an Other group because there are only (Prognostic variables on lung cancer cases were recorded including stage, age, sex, smoking history, histology at diagnosis, and time to death or censoring measured from diagnosis of NSCLC. We exclude small cell lung cancer (SCLC) from our analysis because prognostic models are generally constructed separately for SCLC and NSCLC and staging is determined differently for the two diseasesSurvival curves are estimated using the Kaplan–Meier methodStatistical analysis was performed in R version 4.1.1. The R packages gtsummaryDe-identified PLCO data was obtained from the Cancer Data Access System (CDAS) under approved project PLCO-808 (