Procedures
tumor, Tumor, Cancer
ADVERSE EVENT, TUMOR, TUMOR, ADVERSE EVENTS, ADVERSE EVENT, CANCER
Patients in cohort 1 received intravenous camrelizumab 200 mg every 3 weeks plus oral apatinib 250 mg daily, and patients in cohort 2 received apatinib monotherapy in the first two weeks to modify the immune-resistant microenvironment, and then they were administered camrelizumab plus apatinib. The doses were chosen on the basis of previous published phase I studies in advanced cancersBaseline assessment was done within 14 days before treatment, which included thoracic contrast-enhanced CT and abdominal-pelvic and head neck contrast-enhanced CT or MRI scans; electrocardiogram or echocardiography; biochemical, hematological, virological, endocrinological, and urine and feces examinations; and archival tumor tissue assessments. Tumor response was assessed by investigators, according to RECIST version 1.1, used CT and MRI scans every 6 weeks for the first 12 cycle, and every 12 weeks thereafter. Complete or partial response was confirmed by subsequent scans at least 28 days apart. Routine blood and hepatic, renal function examinations, hematological, biochemical, endocrinological, and urine and fecal examinations were done every cycle. Adverse events were monitored before each drug administration and at each examination throughout the treatment process, and at 30 days (30, 60, and 90 days for serious adverse events) after the last dose of the study drug. Adverse events were graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events version 5.0.