Statistical Analysis
Randomization was performed by a computer-generated random sequence with permuted blocks. The power calculation was based on previous articles investigating the effect of acute administration of fasudil and enalaprilat on IMR.The primary analysis was performed as a within-participant comparison of the primary parameter using a linear mixed-regression model with a patient random intercept, condition, and period as well as their interaction as fixed factors and age and sex as covariates. Secondary end points were analyzed using the Wilcoxon test. Data are presented as median (IQR). All 