Discussion
acute myeloid leukemia, tumor, inflammation, Comorbidity, malnutrition
ACUTE MYELOID LEUKEMIA, CANCER PROGRESSION, TUMOR, PROLIFERATION, INFLAMMATION, DISEASE, INVASIVE CANCER, MYELODYSPLASTIC SYNDROMES, MALNUTRITION, HEMATOLOGICAL MALIGNANCY
DRI, HCT-CI, and CAR were the components of the developed OS nomogram. Previous studies using multivariate analysis also demonstrated significant associations between these prognostic variables and OS in patients following haplo-HSCT. Our results reconfirmed the conclusions of these investigations. In this research, we found that CAR was negatively correlated with OS following haplo-HSCT. Furthermore, we proposed a nomogram for stratifying patients at the time of haplo-HSCT by incorporating CAR into the established DRCI scoring system. The nomogram outperformed the DRCI in predicting OS in haplo-HSCT cohorts, which gave clinicians more flexibility in making personalized decisions about the medical management of patients after haploidentical HSCT.DRI, which originated from the underlying hematological malignancy, cytogenetics for acute myeloid leukemia and myelodysplastic syndromes, and disease status at the time of transplantation, is a validated tool commonly used to predict survival outcomes following HSCT. This score is available for patients receiving HSCT independently of age, the pretreatment intensity regimen, and the graft source (The HCT-CI is a modified version of the Charlson Comorbidity Index (According to studies, malnutrition and systemic inflammation are significantly associated with worse outcomes in patients who underwent HSCT (The cutoff of CAR has differed among studies (The precise mechanism underlying the role of CAR in cancer progression is uncertain and potentially complex. Our investigation demonstrated that high CAR was significantly related to DRI. (P = 0.0015), suggesting that higher CAR is correlated with more invasive cancer behavior in patients following haplo-HSCT. This might be explained by the possibility that tumor cells release cytokines that induce CRP elevation or that CRP elevation is a substituted marker for the active release of cytokines that promote tumor cell proliferation (There are some limitations to this study, despite our nomogram incorporating CAR having significantly better predictive accuracy than DRCI. First, This research is retrospective rather than prospective, which might have resulted in data bias. Furthermore, the study relied on clinical data from our single center database, and there was no external validation. Third, during the duration of the study, nutritional interferences, for example, using intravenous supplementation for patients with decreased food intake, was an integral element of the standard treatment. However, In this study, it was not possible to analyze the influences of these interferences on inflammatory and nutritional conditions and transplantation outcomes. Thus, the results of our research require additional confirmation 