Dantrolene prevents myocardial structural and molecular damage
INTERSTITIAL FIBROSIS
Analysis of the myocardial structure showed an increase in interstitial fibrosis in the HF group compared to the normal controls. Whereas the fibrotic tissue was twofold higher in the untreated HF group compared to normal hearts, the HF+DS group displayed lower fibrotic tissue thereby confirming that DS therapy was delaying the progression of HF, keeping the myocardial architecture intact (