Introduction
epileptic, seizures, convulsive seizure
EPILEPTIC, GENERALISED CONVULSIVE STATUS EPILEPTICUS
Generalised convulsive status epilepticus (GCSE) is a diagnostic and therapeutic emergency and is defined as a convulsive seizure lasting more than 5 min, or as consecutive seizures without recovery of consciousness between seizures [Experts therefore considered that interventions should be proposed as treatment adjuncts to the recommended first- and second-line ASMs, for better controlling the epileptic process (namely, anti-epileptic activity) and to improve recovery (i.e. neuroprotective activity) in GCSE patients admitted to the ICU, as these represent GCSE cases at high risk of poor outcomes [We conducted a multicentre, double-blind, randomised controlled, and pragmatic trial to assess whether the addition of intravenous VPA to the recommended stepwise anti-epileptic strategy in patients admitted to the ICU for GCSE, would increase the number of living patients discharged from hospital by day 15 after GCSE onset [