Eligibility criteria
tumor, skin cancer
TUMOR, CARDIOVASCULAR DISEASE, NEOPLASMS, METASTATIC DISEASE, SKIN CANCER, CERVICAL CARCINOMA, ONCOLOGY
Inclusion criteria were biopsy proven LARC with cT3-4N0-2M0 (any tumor site) or T2N1-2 M0 (only lower rectum) stage; age ≥ 18 years; Eastern Cooperative Oncology Group performance status ≤ 2; adequate hematological count and liver/renal function. Exclusion criteria were as follows: patients unfit for chemotherapy or surgery, metastatic disease not amenable for local radical treatments, pregnant or breast-feeding, severe cardiovascular disease, prior pelvic radiotherapy, patients with other primary neoplasms (except non-melanoma skin cancer or in situ cervical carcinoma), and patients not able to provide informed consent.