Medical intervention
Cardiac arrest
BLOOD, COLD, CARDIAC ARREST
All patients underwent cardiac surgery applying standard protocols by Prof. Dong-Jin Wang. The ascending aorta was cannulated with a patient size-appropriate cannula. Venous cannulations were chosen with separate cannulas in the superior and inferior vena cava. Based on an active clotting time of more than 480 s, heparin (200–400 U/kg) was used to achieve anticoagulation. Systemic temperature was kept in a range of 32–34 °C. The CPB circuit was primed with 1500–2000 ml of sodium acetate Ringer’s injection, 10–30 g of albumin, and 2.5 g of magnesium sulfate injection (concentration: 10%). The initial volume of the antegrade cold blood cardioplegia solution (4:1 ratio) was needed for the cessation of all cardiac electrical activity but never less than 20 ml/kg. Cardiac arrest was maintained, after 30 min of initiated antegrade infusion, by the retrograde infusion of 10 ml/kg of blood cardioplegia solution every 15 min. The antegrade strategy would be following implemented if retrograde infusion had been used 3 times. All patients were transferred to the intensive care unit (ICU) after surgery and then were extubated within postoperative 24 h. Patients in two groups would be given colchicine or placebo for the first postoperative days after tracheal extubation. Blood samples for cTnT, cTnI, CK-MB, MYO, BNP measurement and other markers were obtained at admission and then on the first postoperative day (POD1), the second postoperative day (POD2), the third postoperative day (POD3), the fourth postoperative day (POD4), and the fifth postoperative day (POD5).