Discussion
tumor, T stage, colorectal cancer, gastroesophageal junction malignancies, liver metastases, Malignant tumors, gastric cancer
BRAIN METASTASIS, TUMOR, COLORECTAL CANCER, LIVER METASTASES, LUNG METASTASIS, MALIGNANT TUMOR, LUNG METASTASES, GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA, LYMPH NODE METASTASIS, REGRESSION, BONE METASTASES, GASTRIC CANCER
The survival of patients with metastatic Siewert type II GEJA is influenced by multiple factors, such as pathological type, age, metastatic pattern, degree of differentiation, and treatmentIn this retrospective study, a nomogram that can predict the risk of liver metastases resulting from GEJA was constructed. And its accuracy was verified by the ROC curve, C index, and calibration curve. Through univariate and multivariate logistic regression, we finally identified age, tumor size, N stage, T stage, bone metastases, and lung metastases as factors affecting liver metastases in gastroesophageal junction adenocarcinoma.We found that the likelihood of liver metastases in GEJA patients decreased with increasing age. A previous study found that colorectal cancer incidence increases with age, but metastatic spread decreases with ageWe found that tumor size was also an important factor affecting the happening of liver metastases in GEJA patients, and the larger the tumor size, the higher the risk of liver metastases. It has been previously reported that the risk of lymph node metastasis increases with increasing tumor size in patients with Siewert type II T1-T3 GEJAAs shown in Fig. T staging of gastroesophageal junction malignancies is based on the degree of invasion. However, to our surprise, we found that the higher the T stage, the lower the risk of liver metastases in GEJA patients. We also found that the risk of liver metastases in gastric cancer decreased with increasing T stage. Nevertheless, more evidence is needed to confirm the relationship between the T stage and liver metastases in GEJA patients.Malignant tumors can metastasize to other organs in the body through blood spread. Therefore, it is not surprising that there is a correlation between bone metastases and lung metastases, and liver metastases. However, we found no correlation between brain and liver metastases in our study (Therefore, age, tumor size, T stage, N stage, lung metastasis, and brain metastasis all affect the occurrence of liver metastases in GEJA patients. The nomogram we constructed can accurately predict the likelihood of liver metastases in GEJA patients and better guide clinical practice.