Manufacture and characteristics of gavo-cel product
A single apheresis was sufficient to manufacture a gavo-cel product meeting the protocol-specified doses for all patients infused on the study. The median time from leukapheresis to gavo-cel production start was 11 d (range, 3–260 d). The median transduction efficiency was 49% (range, 33–80%), and the median vector copy number in the manufactured product was 2.47 per cell (range, 1.19–6.67).The median T cell fold expansion during the manufacturing process was 30.9 (range 22.8–43.1) (Extended Data Fig. The polyfunctionality of selected gavo-cel products (