Study design and population
PD, renal anemia, organic dysfunction, Kidney Anemia
RENAL ANEMIA
This trial evaluated the efficacy and safety of roxadustat in regulating iron metabolism in PD patients through 24 weeks of observation. The eligible patients who agreed to participate in the study were numbered according to the time of visit to the hospital, and were divided into roxadustat group and ESA group with a ratio of 2:1 by random number table. This study was approved by the Ethics Committee of the Affiliated Hospital of Xuzhou Medical University (XYFY-KL39-01) and completed Chinese Clinical Trial Registration (registration number: ChiCTR2200057231), and all the enrolled patients signed an informed consent form. Eligible patients ranged in age from 18 to 75, had received stable PD for > 6 weeks, did not receive ESAs, roxadustat, and iron supplementation within 6 weeks before enrollment, and met the clinical diagnosis criteria of renal anemia as stipulated in the Chinese Expert Consensus on the Diagnosis and Treatment of Kidney Anemia (2018 Revision). Exclusion criteria included severe organic dysfunction of the heart, liver, lung, and brain, a change in the dialysis method, transfusion, and intravenous iron.