Strengths and limitations
This study comes with several strengths, including the overall strengths of the COVID STEROID 2 trial, that is, a relatively large, international pragmatic trial with blinding and limited missing data.The study also has limitations, including those general to the COVID STEROID 2 trial, that is, the evolving pandemic and changes in care during and after the trial (i.e., recommendations in favour of interleukin‐6 receptor antagonists introduced after randomisation concluded