5. Conclusions
obesity, T2D, adiposity, prediabetes
OBESITY, ADIPOSITY, INSULIN SENSITIVITY, PREDIABETES
In summary, increased MCP-1 and IL-1ra were predictors of insulin sensitivity, independent of age, sex, and adiposity among Latino youth with obesity and prediabetes. Lifestyle intervention did not lead to relevant changes in pro- and anti-inflammatory markers. Whether changes in these inflammatory markers enhance the reduction of T2D risk factors following lifestyle intervention among high-risk Latino youth may warrant more aggressive interventions. Future rigorous trials are needed to examine the effects of lifestyle intervention on pro- and anti-inflammatory markers and associated changes in insulin sensitivity and β-cell function among high-risk youth populations.