Chest imaging and [89Zr]-rituximab PET
rheumatoid arthritis
RHEUMATOID ARTHRITIS, LIVER, FIBROTIC NON-SPECIFIC INTERSTITIAL PNEUMONIA
Physiological [89Zr]-rituximab blood pool activity was observed (large vessels, cardiac chambers). Liver activity was stable in all patients, whereas spleen activity was variable. [89Zr]-rituximab expression in the lungs manifested as diffuse and patchy areas at different locations. Most active areas on [89Zr]-rituximab were not colocalized with HRCT abnormalities. However, in some cases with clinical response, [89Zr]-rituximab uptake correlated with HRCT findings (Fig. [89Zr]-rituximab PET/CT and HRCT of a 65-year-old patient with fibrotic non-specific interstitial pneumonia associated rheumatoid arthritis (case 3). [89Zr]-rituximab PET (top left) axial PET image (top right) fused [