Discussion
memory loss
This study demonstrated a clinical synergistic effect between remimazolam and propofol. When the two drugs are combined, each drug's dose should be reduced. Both remimazolam and propofol have rapid distribution and metabolism. When the dose of one medicine is too small, with quick distribution and metabolism, the process will lead to a rapid decrease in the drug plasma concentration resulting in a rapid reduction in the amount of the drug that can exert a synergistic effect. This is why the EDAccording to the results of this study, if the anesthesia strength produced by 1 mg/kg of propofol is to be achieved, only 0.33 mg/kg of propofol and 0.05 mg/kg of remimazolam are needed for the combined administration. During the maintenance period of anesthesia, the two drugs may be continuously infused. It is also recommended to keep the infusion at this ratio.Drug synergy has been attributed to pharmacodynamic or pharmacokinetic interactions [The protein binding rates of remimazolam and propofol are 92% [Remimazolam shows slightly higher potency in the α1 subunit of the γ-aminobutyric acid subtype A (GABA-A) receptor. The α1 subunit has been implicated in the sedative, anterograde memory loss, and anticonvulsant effects of benzodiazepines [The results of group A also demonstrated a synergistic effect between remimazolam and opioid analgesics [Remimazolam is less effective at suppressing the pharyngeal reflex [This study has the following limitations: (1) this is a single-center study with limited representation, (2) there may be stronger interaction ratios around 0.5ED