fMRI data and RSNs
For both conditions (GHB and placebo), the mean frame-wise displacement was below the critical threshold of 0.5 mm and did not differ between the conditions. Using the network template masks for extracting the homolog network best-fitting ICA components from each subject, we examined the differences between conditions (GHB vs. placebo), in both within- (via voxel-wise analysis) and between-network (via correlation analysis) connectivity. No significant drug effects were found within the DMN, the CEN, and the SN (see Spatial distribution of bilateral SN in the ICA at both placebo and GHB conditions. The SN is shown in three planes on average Talairach anatomical scan. The MRS-voxel is shown in all planes (green). After correcting for all voxel-level comparisons, no compact clusters with a statistically significant effect was detected (all RSNs and internetwork connectivity patterns. (A) All RSNs are shown in three planes on average Talairach anatomical scan. (B) The anterior and posterior default mode network (A-DMN, P-DMN), the L-CEN, R-CEN, and the SN are considered. The network graph highlights the connections of the SN with the other RSNs (B).Internetwork connectivity scores.The table reports means ± standard deviations. Significant group differences are shown in bold. The internetwork connectivity is quantified using a correlation Time-course of functional connectivity in two components from the ICA corresponding to the SN and the rCEN, obtained from a single subject at both placebo and GHB conditions. The correlation coefficient was calculated between the time-courses of the two networks. The increase in the dynamic coupling of SN-rCEN is testified by a correlation coefficient changing from 