2.1. Vitamin D Antenatal Asthma Reduction Trial (VDAART)
asthma
ASTHMA
VDAART was a randomized controlled trial of Vitamin D supplementation during pregnancy to prevent asthma in offspring conducted in the United States (St. Louis, Boston, and San Diego; NCT00920621). Eight hundred and seventy women were enrolled at 10–18 weeks of gestation and randomized to receive either a high dose of vitamin D oral supplements (4400 IU cholecalciferol daily, called the treatment or high-dose treatment hereafter) or a placebo dose of vitamin D oral supplements (400 IU cholecalciferol daily) between enrollment and delivery. The study protocol was approved by the institutional review boards at each participating institution and at Brigham and Women’s Hospital. All participants provided written informed consent [