1. Introduction
pulpitis, postoperative pain, Pain, fever, tissue injury, edema, arthritis, pain
EDEMA, PULPITIS, ARTHRITIS, MENSTRUAL PAIN
Pain is an unpleasant sensory experience, which is often associated with possible or actual tissue injury [Postoperative administration of analgesics is often imperative to decrease postendodontic pain especially in teeth with irreversible pulpitis [A high level of postoperative pain is a common concern for both patients and dental clinicians, and it can underline patients' trust in treatment. Thus, analgesics, particularly nonsteroidal anti-inflammatory drugs (NSAIDs), are commonly prescribed before and after endodontic treatment [Ibuprofen is among the most commonly prescribed NSAIDs for arthritis, menstrual pain, postoperative pain, edema, and fever. Approximately 80% of ibuprofen is absorbed through the gastrointestinal system when taken orally, and the analgesia onset occurs 30 minutes after use. It is metabolized in the liver and has a half-life of 1.8 to 2 hours. Also, it is mainly excreted in urine and slightly through the bile [Ketoprofen is another NSAID that has a similar structure to ibuprofen since it has a P-phenylpropionic group [Analgesics can be used through oral, injection, inhalation, and transdermal routes. Oral medication intake is associated with possible hepatic primary metabolism, resulting in subsequent elimination of a large part of medication prior to its systemic absorption [Transdermal patch is a relatively novel form of medication delivery. The patch adheres to the skin and releases a certain dose of drug that passes through the skin and underlying tissues to reach the blood vessels [Considering the limited number of studies on the efficacy of analgesic transdermal patches for postendodontic pain control, this study aimed to compare the efficacy of ketoprofen transdermal patch (KTP) and ibuprofen tablets for pain control after endodontic treatment of mandibular first and second molars with irreversible pulpitis.