Tolerability and safety
fatigue, abdominal pain, toxicity, constipation, decreased appetite
ADVERSE EVENTS
Most patients (22/23 [95.7%]) reported at least one treatment-emergent AE. The most frequently-reported AEs were fatigue (10/23 patients, 43.5%), constipation (8/23, 34.8%), decreased appetite (7/23, 30.4%), and abdominal pain (6/23, 26.1%) (see Online Resource 2). One AE led to a dose reduction, but none led to treatment discontinuation. There were 16 SAEs reported by nine patients (39.1%), none of which were considered related to study treatment. No grade 5 toxicity occurred. Related AEs reported for patients in Phase 2a and in those treated at 70 mg/m
Treatment-emergent related adverse events by system organ class, preferred term and worst severity; safety population treated with lisavanbulin 70 mg/m