Author contributions
MM, ARF
ARF
AF and WB conceptualized the study. KB and AF drafted the first version of the manuscript. MM and KB coordinated and supervised the study, and contributed to sample collection and assessment of clinical data. WB developed the analytical techniques, supervised the analyses, contributed to sample collection, and reviewed the manuscript making important contributions. AS prepared the samples, and carried out the mass spectrometry analyses. CW critically revised the manuscript making important contributions. CF Poets supervised the project as the head of department and revised the manuscript for important intellectual input. ARF, the co-coordinator of the project, was responsible for concept and design, contributed to sample collection and the assessment of clinical data, drafted and revised the manuscript. All authors approved the final manuscript as submitted.