3.3. Limitations
Chronic kidney disease, pulmonary edema
CHRONIC KIDNEY DISEASE, PULMONARY EDEMA
The study was performed on a small population, which increases the potential bias. Chronic kidney disease was one of the exclusion criteria, which can potentially limit the generalizability of our results. Another important limitation of our study is the heterogeneity of the patients, including the initially lower baseline levels of EVLWI in the GEDVI-oriented de-escalation group. As we did not observe any intergroup difference in the 48 h fluid balance or in the requirement for CVVH, the more prominent pulmonary edema in the EVLWI-oriented group could be an important confounding factor, explaining the decrement of EVLWI and creatinine concentrations during active fluid removal.