Authors’ contributions
P.T. and E.I. wrote the main manuscript text. P.T., and P.G. recruited the patients, collected and analysed the data. P.T., G.D. and K.T. prepared the tables. P.T., E.I. and A.V prepared the figures. G.D., A.V. and K.T. inserted the idea of the study and had the supervision of the whole project in its entirety. All authors reviewed and commented on the manuscript.