Study design
This is a single-blind, randomized controlled clinical trial with two parallel groups. Ethical approval was obtained from the Ethics Committee for Clinical Trial of Hebei General Hospital, China (ethics approval no. 2019-48, ethics approval date: 29/04/2019). Informed consent was signed by each participant (or legal representative). The clinical trial registration number was ChiCTR-2,000,038,243 (First trial registration: 15/09/2020).