Participants
endometriosis, necrotic
ENDOMETRIOSIS, NECROTIC, BLIND, SECONDARY AMENORRHEA, MALE INFERTILITY
Infertile women (18-42 years old) who were candidates for IVF with frozen embryos
with no history of severe male infertility, severe endometriosis grades 3 and 4,
primary and secondary amenorrhea were included in the study, those patients
willing to participate. Patients with necrotic and low-quality embryos after
thawing or having no live embryo after the thawing procedure were excluded from
the study.The sample size was calculated on basis of a pilot study. The frequency of
chemical pregnancies calculated was 0.35% in the control group and 0.55% in the
intervention group. In this study, the minimum sample size, keeping an alpha
error of 0.05 and a beta equal to 0.2, was calculated to be 196 people (98
subjects in each group). Due to the probability of sample dropout rate, about
10% were added to the above number and the final sample size was 107 people in
each group.The 214 women were divided randomly into two groups. Random allocation was
performed using a computer generated random list. The researcher who did
sonography as well as the analyst did not know the treatment of patients and
groups. It was not possible for patients to be blind, because the type of drugs
prescribed to them (injectable or oral) were different in the two groups.