Background and rationale
deaths, ALS
AMYOTROPHIC LATERAL SCLEROSIS, AMYOTROPHIC LATERAL SCLEROSIS 1, RARE DISEASE
Amyotrophic lateral sclerosis (ALS) is a chronic non-communicable neurodegenerative rare disease that affects approximately 40,000 individuals in Europe, leading to around 11,000 deaths each year [The ongoing “Safety and efficacy of tauroursodeoxycholic acid as add-on treatment in patients affected by amyotrophic lateral sclerosis” (TUDCA-ALS) study takes advantage of the results of a recent proof-of-concept phase IIb study [