Findings
neurodevelopmental impairment
SECONDARY
In this secondary analysis of the Transfusion of Prematures (TOP) randomized clinical trial, mean cerebral saturation (Csat) and mesenteric saturation (Msat) were significantly increased after RBC transfusion in 2 hemoglobin threshold groups, with no statistical difference in the magnitude of increase between groups. Mean pretransfusion Csat less than 50% occurred more frequently in infants who died or developed neurodevelopmental impairment at 22 to 26 months corrected age.