Authors’ contributions
Huan Zhou, Yunqiu Xie, and Hongtao Li contributed to the conception and design. Hongtao Li, Xiangdi Zhao and Jing Xie participated in the writing of the manuscript. Xingyu Zhu, Yue Su, Cuixia He, Jiaxiang Ding, Minhui Zhu, and Yuanyuan Xu were responsible for disposition of biological samples. Ying Wang was in charge of the management of tested drugs, and Rongfang Shan contributed to the study organization and implementation. Bingyan Liu and Yuzhou Ding participated in sample collection. Yuanyuan Liu contributed to quality control throughout the study. All authors read and approved the final manuscript.