Strengths and limitations
MCI, cognitive impairments, AD dementia
This study has some limitations. First, although we recruited and included additional patients in an independent trial, it was still a small Asian population. Therefore, it is necessary to verify the results through an international, large-scale trial. Comprehensive longitudinal studies are required. Second, our study performed brain MRI, amyloid PET, and Despite these limitations, this study’s findings are meaningful. We found that the machine learning model achieved a high level of external validation accuracy in several algorithms. Moreover, our proposed machine learning method showed high accuracy and stability compared with statistical linear models in external validation. Therefore, our results suggest that this novel method can be a potential indicator for identifying cognitive impairments, such as AD dementia and/or MCI.