Lessons learned and future research
RECRUITMENT, ENCEPHALITIS
Further research is required to establish whether early IVIG is of therapeutic benefit in the treatment of childhood encephalitis, irrespective of the underlying aetiology. The IgNiTE study demonstrated the feasibility of conducting a randomised controlled trial to investigate this important question. Future studies should anticipate the recruitment challenges discussed above and consider strategies such as incorporating a pilot phase, using less strict entry criteria, allowing a wider time frame in which participants can be enrolled, and adopting approaches to optimise consent rates in eligible patients.