Trial setting and population
acute metabolic disorders, liver or heart disease, prediabetes
PREDIABETES
The trial was conducted in the HIV clinics of four hospitals in Dar es Salaam, of which three were public hospitals (Amana, Mwananyamala and Temeke Hospitals) and one was a not-for-profit hospital (Shree Hindu Mandal Hospital). These hospitals serve largely urban populations.There is no consensus on how to define prediabetes [Individuals were invited for screening if they were aged 18 years or older, on ART, regularly attending their HIV clinic for at least 6 months, were not pregnant, did not have a history or clinical evidence of acute metabolic disorders, or kidney, liver or heart disease, and had no contraindication to metformin. Two methods were used to screen individuals to assess their eligibility: (1) purposeful sampling, whereby individuals known or suspected to have prediabetes or individuals with a high BMI (>30 kg/mIndividuals were considered eligible if they had: (1) BMI >30 kg/m