Statistical Analyses
dementia, MCI
SECONDARY
Information on sample size determination is reported in the eMethods in Continuous variables are described as median and IQR and categorical variables as numbers and percentages. The main outcome of the study was assessed in the whole group and for the 3 individual cognitive stages (SCD+, MCI, dementia) using tests for equality of proportions. The 3 tests on the individual cognitive stages were adjusted using Bonferroni corrections. Subsequently, we assessed the main outcome also including arm 3, and post hoc pairwise comparisons (ie, arm 1 vs arm 2, arm 1 vs arm 3, and arm 2 vs arm 3) were adjusted using Bonferroni corrections. For the analyses of the secondary end points, differences were assessed using a Kruskal-Wallis rank sum test for continuous variables or test for equality of proportions for categorical variables. In case the number of groups in the comparison was larger than 2, post hoc pairwise comparisons (Dunn all-pairs rank comparison test for continuous variables or pairwise comparisons for proportions) were adjusted using Bonferroni correction. Significance was set at Data analysis was performed from July 2022 to January 2023. The statistical analysis of the main outcome was performed with SPSS version 27. The statistical analyses of the secondary outcomes were performed with R version 4.1.2 (R Foundation for Statistical Computing).