Power analysis
When enrolling The SMART design also allows us to address several questions relating to the embedded dynamic treatment regimens (DTRs). We expect to have sufficient numbers in even the smallest groups in Stage 2 to derive meaningful insights for future trials: We have at least 90% chance to have 26 individuals to enter the smaller of the re-randomized groups in Stage 2 in each of the initial arms, assuming a 50% non-adherence rate in the first-line treatment and accounting for 10% attrition (90% chance of at least 20 individuals with 40% non-adherence rate in first-line treatment; computations used specialized R-code provided by [