Introduction
critically ill, end-stage liver disease, liver insufficiency, brain dysfunction, liver cirrhosis, coma, Sequential organ failure
DISORDER, CRITICALLY ILL, HEPATIC ENCEPHALOPATHY, BRAIN DYSFUNCTION, LIVER CIRRHOSIS, SECONDARY, COMA, REGRESSION
Hepatic encephalopathy (HE) is a severe brain dysfunction secondary to liver insufficiency or portal shunt, in which clinical symptoms vary greatly from slight mental disorder to coma [By far, there is no specific survival prediction model for patients with HE in the ICU. The severity scores of critically ill patients commonly used in ICU include the Sequential organ failure assessment (SOFA) score, the model for end-stage liver disease (MELD) score, and so on. The model for the MELD score was first proposed by Malinchoc et al. to predict the mortality of end-stage liver disease undergoing jugular intrahepatic portosystemic shunt [Currently, prognostic systems based on risk scores have been widely used in critically ill patients [This study aimed to determine the risk factors related to the 90-day survival of patients with liver cirrhosis and HE in ICU and to establish a new prognostic nomogram based on the results of the multivariate Cox regression. The new nomogram was compared with that of the separate SOFA model, and its performance was verified in the validation cohort.