Abstract
deaths, bacterial infections, infections
BACTERIAL INFECTIONS, INFECTIONS

All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.There is a crucial need for novel antibiotics to stem the tide of antimicrobial resistance, particularly against difficult to treat gram-negative pathogens like Drug-resistant bacterial infections caused an estimated 4.95 million deaths worldwide in 2019 [Historically, antimicrobial drug development has focused on discovering broad-spectrum agents that can be used as empiric therapy to treat serious infections [