Statistical analysis
The intent-to-treat (ITT) set encompassed all participants administered the treatment. The per-protocol analysis (PP) set included all participants with high compliance with the study protocol and strictly completed the trial processes per the study protocol. All participants in the PP set completed the drug therapy throughout the study according to the protocol.Data were analyzed with SPSS 22.0 (SPSS, USA). Normally and skewedly distributed continuous variables were presented as mean ± standard deviation and median (range), respectively. Categorical variables were presented as n (%). Kaplan-Meier curve analysis was utilized to estimate PFS and OS.