Lurbinectedin treatment
neutropenia, leukopenia, febrile neutropenia, hematological toxicity, anemia
LEUKOPENIA, NEUTROPENIA, ANEMIA, FEBRILE NEUTROPENIA
A total of 378 cycles were administered to the 73 treated patients. The median number of cycles per patient was 4 (range, 1–22 cycles), with 31.5% of patients having received ≥ 6 cycles. The median relative dose intensity was 97.7% (range, 64.9–102.9%). Twenty patients had treatment-related dose delays, being hematological toxicity the most common reason: grade 2–4 neutropenia in 13 patients and grade 3 anemia in two patients. Lurbinectedin dose was reduced due to treatment-related reasons in 6.9% of cycles in 20 patients, being hematological toxicity the most common cause: grade 2-4 neutropenia in eight patients and eight cycles; grade 3/4 febrile neutropenia in two patients and two cycles; and grade 3 leukopenia in one patient and one cycle. Of note, the protocol stated that in case of grade 4 neutropenia, lurbinectedin dose had to be reduced instead of continuing at the same dose with granulocyte colony-stimulating factor (G-CSF) prophylaxis.