Discussion
obesity, Obesity, age-related neurodegenerative disorders, inflammation, Chronic adipose tissue, cognitive dysfunction, Alzheimer’s disease, Inflammation, metabolic syndrome
OBESITY, OBESITY, INFLAMMATION, RESPIRATORY FAILURE, INFLAMMATION, CARDIAC COMPLICATIONS, METABOLIC SYNDROME, COMPLICATIONS
In this study, we successfully described the profiles of cognition and inflammation before and after bariatric surgery. Among adults with obesity, cognition was significantly improved in 3 months after LSG. QLB, as an adjunct to the general anesthesia, significantly promoted cognitive improvement in MoCA. Significant reductions of pro-inflammatory cytokines and an increase of BDNF were also observed during the postoperative follow-up. There were possible correlations between cognition and changes in peripheral inflammatory cytokines, especially pro-inflammatory cytokines in postoperative 3 months.Obesity itself is sufficient to impair cognition [On the other hand, according to the analysis of 122 studies from 1946 to 2020, PNB is associated with decreased occurrence of numerous complications after total hip and knee arthroplasties, such as cognitive dysfunction, respiratory failure, and cardiac complications [Chronic adipose tissue inflammation and associated increases of circulating pro-inflammatory adipokines are typically displayed in patients with obesity. Inflammation has been regarded as a critical mechanism of cognitive dysfunction in human [Brain-derived neurotrophic factor (BDNF), as a member of the neurotrophin family, originally supports the development, maintenance, and plasticity of the central and peripheral nervous systems. BDNF signaling also contributes to the development of the metabolic syndrome and obesity under a circumstance with chronic positive energy balance. At the same time, the reduction of BDNF enforces the susceptibility to Alzheimer’s disease and other age-related neurodegenerative disorders [Noteworthy, the addition of dexmedetomidine may partially participate in the changes of cognition and inflammation induced by TAPB or QLB in this study. Dexmedetomidine is a selective There are also some limitations in our study. Some bias might affect inflammatory cytokines assessments, especially BDNF measurements, such as physical exercise [