INTRODUCTION
RSV, Infection, lower respiratory tract disease, LRTD
ADENOVIRUS, RESPIRATORY SYNCYTIAL VIRUS (RSV), INFECTION
Despite near-universal pre-exposure, respiratory syncytial virus (RSV) can cause severe lower respiratory tract disease (LRTD) among older adults (Infection with RSV does not confer long-lasting immunity (Ad26.RSV.preF is a recombinant, replication-incompetent adenovirus type 26 (Ad26)-based RSV vaccine encoding a conformation-stabilized RSV pre-fusion F (preF) protein. A combination regimen consisting of Ad26.RSV.preF and a recombinant RSV preF protein has demonstrated a promising vaccine efficacy of 80.0% for the prevention of RSV-mediated LRTD in older adults (aged ≥65 years) (