Author contributions
N.J.S. designed the study, enrolled patients, collected and analyzed the data and wrote the manuscript; M.M., M.B. and M.A. performed the CyTOF analyses; F.O., L.N., W.M., W.Q. and X.H. performed statistical analyses; G.M-B., Y.A., N.D., C.D.D., G.B., N.J., M.O., E.J., G.C.I., P.B., F.R., R.D. and R.A. enrolled patients; G.G-M., J.C. and H.K. designed the study and enrolled patients; R.K-S. and K.P.P. performed analyzed hematopathology samples. All authors reviewed and edited the manuscript and approve of the final version.