Methods
BPD
SECONDARY
We performed a secondary post hoc analysis of the NICHD NRN Hydrocortisone Trial, which was a double-masked, placebo-controlled, randomized clinical trial that enrolled 800 infants from 19 academic centers in the US. Participants were enrolled between August 22, 2011, and February 4, 2018, with follow-up between 22 and 26 months of corrected age completed on March 29, 2020. The centers’ institutional review boards approved the trial, with written informed consent provided by a parent or guardian prior to enrollment. The trial protocol is found in The definition used for BPD was physiologic moderate or severe BPD assessed at a PMA of 36 weeks,Data were analyzed from September 13, 2021, to March 25, 2023. The primary outcome for the present analysis used the recently proposed evidence-based BPD grade definition To test model performance, in accordance with the Predictive Approaches to Treatment Effect Heterogeneity (PATH) statement recommendations,To describe the magnitude of effect modification,