Selection of subjects
porphyria, malnutrition
BLOOD DISEASES, SCAR, PORPHYRIA, MALNUTRITION
The inclusion criteria included an age range of healthy subjects of 18~50 years for men or women and a body mass index ranging from 19.0 to 26.0 kg·mThe exclusion criteria included subjects with abnormal vital signs; clinical/laboratory tests (blood routine, urine routine and blood biochemical, serology, electrocardiogram (ECG)), cerebrovascular, liver, kidney, respiratory, blood, endocrine, immune, mental, or gastrointestinal diseases; porphyria, malnutrition or blood diseases; scar constitution; analgesic use in the past 2 weeks; long-term drinking of tea and coffee, blood donation within the past three months; and participation in other drug clinical trials within the past three months.A total of 50 healthy subjects were selected, with no restriction regarding gender. They were informed about the purpose, procedure, possible benefits and risks of the study and signed the informed consent form.