Bioinformatic and prognostic detection of complement factor D during tendon repair
inflammation
INFLAMMATION, PROLIFERATIVE
In total, 769 unique proteins were identified from the biopsies as representative of the inflammatory stage of healing, whereas 1423 proteins were detected from microdialysates representing the proliferative healing phase of DCT repair. After combining proteomic profiles from both phases, CFD was detected to be significantly associated with patient outcome in both the inflammatory and proliferative healing stages, although with opposing effects. Interestingly, elevated CFD levels were detected during the inflammatory phase (Prognostic significance of CFD and its potential role in tissue regeneration based on the inflammation-related proteomic file. At the inflammatory healing stage, higher CFD expression was observed in good outcome patients (In the next step, all the differentially expressed proteins considered as healing-related biomarkers between good and poor outcome patients at both phases were used for the detection of biological processes or pathways based on GO annotation and KEGG database. At the inflammation stage, two highly enriched protein-protein interaction networks were detected, which were associated with extracellular matrix (ECM) organization (