Multivariable models
microvesicular steatosis, NASH, lobular inflammation
INFLAMMATION, INFLAMMATION
In a multivariable model evaluating independent risk factors for NASH improvement at 96 weeks of follow-up, based on biopsy results, including treatment assignment group, sex, LTL, age of enrollment, waist circumference, fasting glucose and alkaline phosphate baseline levels, the only variable that neared statistical significance was fasting glucose level (Odds Ratio (OR), 0.96, 95% CI 0.92–1.01, p = 0.09) in addition to treatment assignment group (vitamin E) (Table Predictors of NASH improvement* at 96 weeks.*Based on biopsy.Predictors of leukocyte telomere length at baseline.Leukocyte telomere length association with lobular inflammation multivariable analysis.Predictors of Lobular Inflammation Worsening at 96 Weeks (n = 131).Predictors of lobular worsening at 96 weeks.Lastly, we ran a final model of lobular inflammation worsening at 96 weeks but included specifics from the biopsy report that were predictive of lobular improvement in biariate analysis. Specifically, we included presence of acidophil bodies and microvesicular steatosis at baseline (both which were significantly associated with lobular inflammation in univariate analysis). In a multivariable model adjusting for all the previous covariates mentioned in the previous lobular inflammation model, neither were associated with lobular inflammation worsening (results not shown).