Author Contributions
D.B., C.L.O., C.D. and M.M. contributed to the study design. C.L.O. performed all aspects of the clinical trial. DNA sequencing was performed by DNASense, while cytokine activity was analyzed by M.G. and U.K.G. at Turku University, and protease activity was analyzed by A.V.S. and F.J.B. at ACTA University. DNASense, V.F.D.V., L.M. and C.L.O. performed the biostatistical analyses. DNA sequencing and statistical analyses performed by DNASense were executed as a pay-for-service. C.L.O. and D.B. wrote the first draft of the manuscript. C.D., M.M., V.F.D.V., L.M., U.K.G. and F.J.B., critically revised the manuscript. All authors have read and agreed to the published version of the manuscript.