Acknowledgements
We wish to thank Takayuki Kifuji and Kazumi Hyoudou for designing the first-in-human study, and Akihide Tsujimoto and Shio Maruyama of Mitsubishi Tanabe Pharma Corporation for performing the pharmacokinetic animal studies. Medical writing assistance was provided under the direction of the authors by Rajgopal Yadavalli, PhD, and Brittany Eldridge, PhD, of Cadent Medical Communications, LLC, a Syneos Health