Conclusions:
cough, Cough
Airborne ethyl butyrate is a tussigenic agent in humans. Our findings provide opportunities for future research directions in normal and disordered cough responses to volatile compounds.Cough involves a well-coordinated sequence of respiratory maneuvers necessary for adequate airway protection. Specifically, the respiratory act of coughing includes initial inspiration, laryngeal compression to permit the buildup of air pressure, and expulsion to forcefully eject material from the airway (Traditional research methods of eliciting cough include inhalation challenges via aerosol delivery of tussigenic agents, primarily capsaicin and citric acid (While the majority of available human cough methodologies rely almost exclusively on aerosolized, nebulized, and distilled deliveries of tussigenic agents, there is growing interest in the use of alternative stimuli for more clinically feasible airway provocation challenge tests (Ethyl butyrate (EB) is a volatile ester that is found naturally in foods such as kiwi fruit and blue cheese (Breath control techniques are a major component of behavioral speech therapy for CHS (