Background
NAFLD, obesity, cardiac dysfunction, ASCVD, CVD, left ventricular systolic dysfunction, T2DM
OBESITY, ASCVD, LEFT VENTRICULAR SYSTOLIC DYSFUNCTION, CVD, NONALCOHOLIC FATTY LIVER DISEASE, ATHEROSCLEROTIC CARDIOVASCULAR DISEASE, TYPE 2 DIABETES MELLITUS
The prevalence of Nonalcoholic fatty liver disease (NAFLD) is increasing in parallel with the worldwide increase in obesity and type 2 diabetes mellitus (T2DM) [The relationship between NAFLD and CVD is complex [Global longitudinal strain (GLS) is one of the most sensitive and accurate echocardiographic measures for assessing LV mechanics and determining subclinical left ventricular systolic dysfunction [To the best of our knowledge, no previous study has compared the effects of empagliflozin and pioglitazone on subclinical cardiac dysfunction that is associated with NAFLD. The present study was designed to compare the impact of these two agents on echocardiographic indices in individuals with T2DM and NAFLD who did not have established atherosclerotic cardiovascular disease (ASCVD).