Outcomes
UTIs, urosepsis
COMPLICATIONS, SECONDARY, UTI, PYELONEPHRITIS, UROSEPSIS
The primary outcome was the proportion of second line antibiotics prescribed in relation to all antibiotics prescribed for uncomplicated UTIs after one year, calculated as the absolute difference in the mean proportion of the prescriptions between the control and intervention group. According to national guidelines, second line drugs were all antibiotics other than trimethoprim, pivmecillinam, nitrofurantoin, fosfomycin, or nitroxoline, which are first line treatments.The secondary outcome was the proportion of all antibiotics prescribed for the treatment of UTIs after 12 months, calculated as the absolute difference in the mean proportion of all antibiotics prescribed between the intervention and control group. The prescription proportion of all antibiotics was defined as the proportion of first line and second line antibiotics within all UTI cases. Other exploratory outcomes were the proportion of high and low prescribers, the changes of prescribing behaviour over time and factors associated with low performance (defined as >10% of second line antibiotic prescriptions).After publication of the study protocol, we added women with UTIs who were treated with any antibiotic after 12 months as an exploratory outcome to assess whether any changes could be observed with the intervention. For this outcome, we calculated the mean difference in the proportion of UTI cases treated with antibiotics in all UTI cases. Furthermore, we added cases with recurrent UTI and complications (eg, pyelonephritis, urosepsis, and hospital admissions) as exploratory outcomes.