Introduction
ARDS
ARDS, SARS-COV-2 INFECTION, ACUTE RESPIRATORY DISTRESS SYNDROME, LEAKAGE
Vascular leakage is a major feature of pathogen-induced acute respiratory distress syndrome (ARDS) [FX06, an innovative drug containing fibrin-derived peptide Bβ15-42, stabilizes vascular endothelial (VE)-cadherin–dependent interendothelial cell junctions [Taken together, those findings indicate that FX06 is well-tolerated by patients and is a potent regulator of vascular leakage during ARDS. We hypothesized that FX06 might limit pulmonary vascular hyperpermeability during ARDS induced by SARS-CoV-2 infection, thereby improving gas exchanges and patients’ outcomes.