Significantly reduced virus loads in the treated rhesus macaques
throat
VIRUS
Nasal, throat, and rectal swabs were collected at 0, 1, 3, 5, and 7 dpi. Significant reductions in viral load were observed in the nasal and rectal swabs collected from nelfinavir-treated monkeys compared to the control group (Fig. On 8 dpi, all monkeys were euthanized. Tissue samples were collected from nelfinavir-treated and vehicle-treated monkeys to compare virus replication. In kidney samples from nelfinavir-treated monkeys, the virus RNA could not be detected while that in the vehicle-treated monkeys is detectable (Fig. We found that the viral loads in several extrapulmonary tissues, e.g., colon and heart, in nelfinavir treatment group have increasing trends in comparison with the control group. However, no statistical difference was found between the two groups (Fig. 