Introduction
glucose intolerance, GDM
GDM, GESTATIONAL DIABETES MELLITUS, GLUCOSE INTOLERANCE
Gestational diabetes mellitus (GDM) is characterized by any degree of glucose intolerance with onset or recognition during pregnancy.The degree to which maternal glucose control affects these biomarkers markers is uncertain. A nested study with the ACHOIS randomized trial suggested that cord adiponectin and leptin concentrations in infants born to women with GDM are influenced by treatment that included dietary advice and pharmacotherapy where necessary.A randomized trial that compared women with GDM assigned to biweekly prenatal clinic care with women with GDM assigned to additional daily feedback on their compliance to glycemic control found that while 66% of women receiving routine care were able to achieve their glycemic targets, this increased to 84% for women in the daily feedback group.Our study aimed to assess whether different intensities of glycemic targets for pregnant women with GDM influence the maternal cardiometabolic markers of triglycerides, cholesterol, CRP, leptin, and adiponectin, and infant cardiometabolic, growth, and inflammatory markers of cord plasma C-peptide, leptin, adiponectin, and insulin-like growth factor (IGF). In addition, we assessed whether achieving compliance to different intensities of glycemic control for pregnant women with GDM influenced these cardiometabolic, growth, and inflammatory markers.