Overview
Pain
As described in the previous section, we generate data sets from 4 different scenarios, each a series of N-of-1 trials on Chronic Nonspecific Low Back Pain with 1000 participants. For the evaluation of the statistical models, in each scenario, we draw 100 samples each of 5, 10, 25, 50 and 100 participants, to also investigate the influence of the sample size in aggregated N-of-1 trials. Then we apply different statistical models, and evaluate their bias and efficiency in estimating the treatment effect difference in outcomes between treatment groups 1 and 2 across all participants. We compare standard statistical models for the analysis of aggregated N-of-1 trials, COAPM, G-estimation, and Bayesian Networks.