3.12. Role of AF-2 domain
RECRUITMENT
The H-12 forms a large portion of the AF-2 surface since stabilization of H-12 allows the receptor to heterodimerize with the retinoid X receptor (RXR) and allows the recruitment of coactivators for PPAR regulated target gene transcription [Forasartan showed interactions with two critical residues: Ser84 of H-3 and His244 of H-10, both of which play essential roles in the agonist-induced activation of PPARα [