Patients
NSCLC, drug-induced lung disease, ILD, Tumors
BRAIN METASTASIS, SMALL CELL CARCINOMA, ADVERSE EVENTS, LEPTOMENINGITIS, BONE METASTASIS, TUMORS, PERICARDIAL EFFUSION, NSCLC, ONCOLOGY, INTERSTITIAL LUNG DISEASE
The eligibility criteria were as follows: age ≥ 20 years and histologically or cytologically confirmed advanced NSCLC with EGFR mutations; an Eastern Cooperative Oncology Group performance status (ECOG-PS) of 0 or 1; acquired resistance to osimertinib; patients who could be treated with 80 mg osimertinib without dose reduction; having at least one or more measurable lesion according to Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1; and provision of written informed consent for study participation.The key exclusion criteria were as follows: unresolved adverse events from previous treatment; a medical history of interstitial lung disease (ILD), drug-induced lung disease, symptomatic brain metastasis, or leptomeningitis; bone metastasis to be treated by surgery or radiation therapy; histologically confirmed small cell carcinoma transformation as a resistance mechanism; uncontrollable pleural, peritoneal, or pericardial effusion; and prior thoracic radiotherapy within the preceding 2 weeks.