Treatment regimen
toxicity, Gastrointestinal Tumors
GASTROINTESTINAL TUMOR
Dosage and schedule were selected according to the results of Phase I study of FTD/TPI Plus Irinotecan and Bevacizumab in Advanced Gastrointestinal Tumors (Varghese AM et al.) [FTD/TPI will be administered at a dose of 25 mg/mThe dosage is calculated according to body surface area (BSA) as displayed in Table Calculation of dosing for FTD/TPI in mg according to BSA used in the TRITICC trial(!) At a total daily dose of 50 mg, patients should take 1 × 20 mg tablet in the morning and 2 × 15 mg tablets in the eveningIrinotecan will be administered at the same time as FTD/TPI on day 1 of each cycle at a dose of 180 mg/mTreatment will be administered until radiological progress or inacceptable toxicity.