4.2. Genes Related to CpG Sites Associated with the Percentage of BMI Loss for the MHP Diet and for the LF Diet
obesity, gastric cancer
OBESITY, GASTRIC CANCER
Another finding of this investigation is the biological role of the genes with the methylation sites in the blood associated with the percentage of BMI loss for both diets. Of these genes, those with functions in the cell cycle, the immune system, and metabolism were highlighted.In an experimental study, they analyzed the epigenetic marks related to obesity and studied the blood methylation of the Another study observed that in vitro gastric cancer cell lines infected with It is important to highlight that, in the present investigation, the study of methylation was analyzed in blood, and in some previously mentioned studies, the methylation of these same genes was studied in target tissues, which demonstrates that blood tissue can serve as a rather similar reflection of methylation status, as it has been analyzed in some studies that compared methylation in a target tissue versus identifying methylation in blood, in which methylation data were considered to be more specific if performed in the tissue of interest for the investigation. But blood is a valid option that can provide fairly accurate information on the methylation status whenever adjustments are made to the blood cell composition, since it has the advantage of being a more accessible tissue, which can be taken routinely [