Cytokine measurement
tumor necrosis
TUMOR NECROSIS
Forty-five analytes were quantified in the plasma using Human XL Cytokine Magnetic 45-plex Luminex Assay (898855, R&D Systems) according to the manufacturer’s instructions: C-C motif chemokine ligand 2 (CCL2), CCL3, CCL4, CCL5, CCL11, CCL19, CCL20, CD40 ligand, fractalkine, C-X-C motif chemokine ligand 1 (CXCL1), CXCL2, CXCL10, epidermal growth factor (EGF), fibroblast growth factor (FGF), FMS-like tyrosine kinase 3 ligand (FLT3L), granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), granzyme B, IFN-α, IFN-β, IFN-γ, IL-1α, IL-1β, IL-1RA, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-15, IL-17A, IL-17E, IL-33, programmed death-ligand 1 (PDL1), platelet-derived growth factor (PDGF)-AA, PDGF-AB/BB, transforming growth factor (TGF)-α, tumor necrosis factor (TNF)-α, TNF-related apoptosis inducing ligand (TRAIL) and vascular endothelial growth factor (VEGF). The performance assay standard values for each analyte are detailed in Extended Data Table 