Posttreatment MRI protocol
Post-sonication MRI of the brain was conducted with the same clinical Siemens 3.0-Tesla Magnetom Prisma MRI unit (Siemens, Erlangen, Germany) by using a 20-channel head coil. Pre- and post-contrast MRI of the brain was performed immediately after completion of each sonication treatment session and again at 24 h following each FUS treatment. MRI was repeated at 48 h post intervention following one or more of the three treatment sessions in 6 out of 8 subjects (Fig. 