Statistical analysis
acute adenoidal infections
The sample size was determined on the basis of the primary endpoint, which was to evaluate the impact of the topical administration of Rinogermina nasal spray on the reduction of the number of acute adenoidal infections, and was computed using published data reporting a 15% reduction of acute exacerbation in children receiving topic probiotic treatment [The results are given as absolute numbers and percentages, or as arithmetical mean values ± standard deviation. The dichotomous outcomes were analyzed using contingency table analysis, and continuous variables using non-parametric tests.A 