Background
ischemia/reperfusion injury
SYSTEMIC INFLAMMATORY RESPONSE, COMPLICATIONS
There are some serious complications after cardiopulmonary bypass (CPB) in patients undergoing cardiac surgery. The lungs are sensitive and fragile organs that are susceptible to ischemia/reperfusion injury and systemic inflammatory response [Penehyclidine hydrochloride is a new type of long-acting selective cholinergic blocker with antimuscarinic and antinicotinic activities. It exerts its anticholinergic activity by selectively acting on M1 and M3 receptors distributed in the alveolar walls, airway smooth muscle, and submucosal glands. It can relax airway smooth muscle, dilate bronchioles, reduce mucus secretion and airway resistance, increase lung compliance, and improve respiratory function [Dexmedetomidine is an α2 adrenergic agonist that selectively acts on parts of the brain or spinal cord. It can promote sedation and analgesia, and is widely used in anesthesia, procedural sedation, and sedation in intensive care [Penehyclidine hydrochloride and dexmedetomidine are commonly used as auxiliary anesthetics, and both have possible organ protective activity when the body is injured or under pathological conditions. However, the effects of combined use of penehyclidine hydrochloride and dexmedetomidine on patients undergoing cardiac surgery with CPB have not been studied. The current study investigated whether penehyclidine hydrochloride combined with dexmedetomidine had a positive effect on pulmonary function of patients undergoing heart valve surgery with CPB.