Liraglutide upregulates adaptive prediction error encoding in the subcallosal area and the NAc
INSULIN SENSITIVITY, CORTEX
As our behavioural analysis revealed that liraglutide intervention significantly enhanced the amplitude of adaptive prediction error encoding in the group with impaired insulin sensitivity, we specifically tested for brain regions in which liraglutide (relative to placebo) enhanced the neural encoding of adaptive prediction error to a greater extent in the group with impaired insulin sensitivity than in the group with normal insulin sensitivity. In the vmPFC and the ventral striatum extending to the NAc, the encoding of adaptive prediction errors was indeed enhanced by liraglutide relative to placebo only in individuals with low insulin sensitivity but not in those with high insulin sensitivity (Table Differential effects of liraglutide on neural tracking of the adaptive prediction errorStatistics for dACC, dorsal anterior cingulate cortex; lOFC, lateral orbitofrontal cortex.