AMR
The following assumptions were used for the AMR sub-sample size calculations:The AMR sub-sample size is based on the following assumptions.95% AMR prevalence of 12% in the control group for Non-inferiority margin of 10 percent-points in AMR prevalence.80% power, one-sided 2.5% type 1 error rate for each pairwise comparison against placebo control.Coefficient of variation of 0.3 in AMR among clusters.