Association Between TILs and iGESs
TILs
INFILTRATION
We found that 166 of 202 iGESs (82.2%) were significantly correlated with TILs in both studies, 179 in the CALGB 40601 trial and 174 in the PAMELA trial (eTable 3 in the To further study the association between TILs and iGESs, we compared the differences in immune cell infiltration, using our CIBERSORT-derived signatures to perform a multiclass significance analysis of microarrays by TIL levels (ie, low, medium, and high) and by IgG signature levels (ie, low, medium, and high) in the CALGB 40601 and PAMELA trials. The standardized mean differences between the iGESs in 1 class vs the overall mean expression are represented in 