1. Introduction
(1) Background: While goat milk formula (GMF) is an alternative to cow milk formula (CMF), infants’ preferences for one over the other have not been formally assessed. Specifically, our aim in this study was to determine whether infants experience fewer feeding behavior problems with whole milk-based GMF than with conventional whey-based CMF. (2) Methods: This was a multicenter, double-blind, randomized controlled trial with two-arm parallel assignment conducted in six pediatricians’ offices in or near Paris, France, between June 2018 and 31 December 2021. Overall, 64 healthy infants (≤4 months old), predominantly formula-fed, were randomly assigned to either the whole milk-based GMF (During the first weeks of life, changes in infant formula for bottle-fed infants are frequent [Although breastfeeding is the most appropriate way to feed infants in the first months of life, most infants are no longer breastfed after 6 months [Goat milk is an alternative source of protein for infant formula. Hence, goat milk formula (GMF), either based on whole goat milk or whey based, offers an alternative to whey-based cow milk formula (CMF) [Taste development in early life is complex and still poorly described [Several randomized and non-randomized trials have compared growth—i.e., changes in weight, length, and head circumference—in children fed a CMF or a GMF. A recent double-blind, randomized controlled trial (RCT) by He et al., comparing a whey-based GMF, a conventional CMF, and breastfeeding in the first 4 months of life, found similar levels of growth between the CMF and GMF groups [Accordingly, in the present study, we compared the feeding behavior and quality of life of infants fed either whole milk-based GMF or whey-based CMF and measured degrees of GI discomfort for these study groups.