Author contributions
HAD
LT and ADF conceived and designed the research; LT, LGI and ADF performed the experiments; LT and ADF analyzed the data; LT and ADF interpreted the results of experiments; LT prepared the figures; LT, and ADF drafted the manuscript; LT, LGI, BKA, SSC, HAD, IBM, ADF edited and revised the manuscript; LT, LGI, BKA, SSC, HAD, IBM, ADF approved the final version of the manuscript.