Conclusions
LEPTOSPIROSIS, CKD STAGE 4
This RCT did not significantly improve the renal function of patients with AIN of unknown aetiology, up to 2 years of follow-up as designed. In the exploratory analysis, there was a slower progression to CKD stage 4 in prednisolone-treated groups. Leptospirosis was accorded as a possible cause for this AIN and adding doxycycline did not have any favourable effect on the outcome. In conclusion, empirical steroid therapy practised by physicians on AIN of unknown aetiology is a potential treatment to delay the progression of CKDu. An adequately powered steroid trial using patients reaching < 30 ml/min/1.73m