DISCUSSION
mild/moderate AGA, mild/moderate
PROLIFERATION, VASODILATION
AGA affects up to 50% of females and 80% of males.Minoxidil is currently the first‐line drug for the treatment of mild/moderate AGA. As an effective vasodilator, which is conducive to hair growth. The mechanism of this action may be related to various ways: potassium ion channels open, stimulate the proliferation and differentiation of hair follicle epithelial cells, promoting angiogenesis and vasodilation to increase local blood supply, directly accelerating the transformation of hair follicles from the resting phase to the anagen phase.PRP is a platelet‐concentrated plasma prepared by extracting autologous blood, with a higher concentration of platelets than blood. The regenerative potential of PRP is related to the levels of growth factors secreted and released by concentrated platelet α particles. PRP enriched with a variety of growth factors including platelet‐derived growth factor (PDGF), transforming growth factor (TGF), vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), fibroblast growth factor (FGF), insulin‐like growth factor (IGF), and so forth. These growth factors affect the differentiation, proliferation, and survival of cells.The clinical efficacy of concentrated platelets depends mainly on the number of platelets and the concentration of growth factors.In this study, all enrolled patients received injections of automated method‐prepared PRP. The results showed that the average hair density and hair counts of all patients after 3 months of treatment were significantly higher than that of pretreatment (There are still some limitations in this study. On the one hand, due to the small sample size of this experiment, AGA patients of different severity have not been grouped and stratified compared, and for a short follow‐up period, the long‐term efficacy of PRP injection therapy could not be assessed. On the other hand, there is no unified standard for PRP preparation, concentration, injection method, course of treatment, and treatment interval of PRP, which may lead to bias in the efficacy evaluation. Therefore, further expansion of the sample size and longer follow‐ups are still needed to explore and determine the method to achieve optimal hair regrowth conditions.In conclusion, our study provides further evidence that PRP injection is safe and effective for the treatment of mild/moderate AGA, and PRP prepared by automatic blood cell separators has high purification quality and high platelet concentration. The injection of automated method‐prepared PRP combined with topical 5% minoxidil therapy was superior to PRP monotherapy in terms of patient satisfaction and clinical efficacy for the treatment of mild/moderate male AGA, it is worthy of clinical promotion.