Baseline and biochemical clinical data in PCOS
polycystic ovaries, amenorrhea, glucose intolerance/diabetes, overweight, oligomenorrhea
POLYCYSTIC OVARIES, DYSFUNCTION, MENSTRUAL DISTURBANCE, INSULIN RESISTANCE, OLIGOMENORRHEA, HYPERINSULINEMIA
The baseline clinical characteristics of the two randomized treatment groups were matched. Both groups had hyperinsulinemia, and participants were overweight with visceral fat accumulation (BMI 27.75 vs 29.23 kg/m²; waist circumference 93.07 vs 95.78 cm; WHR 0.90 vs 0.91 in the CPA/EE + Met group and GLP-1RA + Met group, respectively). They also showed reproductive dysfunction, including loss of dominant follicles (0% of patients had dominant follicles in both groups), polycystic ovaries (40 vs 30%), menstrual disturbances such as amenorrhea (40 vs 30%) and oligomenorrhea (36.67 vs 43.33%), elevated blood testosterone levels, LH levels, and LH/FSH ratio. Moreover, before treatment, the percentage of participants with glucose intolerance/diabetes was 20% in the CPA/EE+Met group and 36.67% in the GLP-1RA+Met group, while nearly 78 .33 %of participants had insulin resistance (mean HOMA-IR over2 .5) [