Background
sepsis, ARDS
SECONDARY, CRITICAL ILLNESS, SEPSIS, ARDS, ACUTE RESPIRATORY DISTRESS SYNDROME
Two acute respiratory distress syndrome (ARDS) trials showed no benefit for statin therapy, though secondary analyses suggest inflammatory subphenotypes may have a differential response to simvastatin. Statin medications decrease cholesterol levels, and low cholesterol has been associated with increased mortality in critical illness. We hypothesized that patients with ARDS and sepsis with low cholesterol could be harmed by statins.
