BMI and blood pressure
The BMI was significantly decreased in the tofogliflozin group throughout the follow-up period but did not change significantly during the main UTOPIA study. However, in the conventional treatment group, the BMI decreased significantly from baseline to the end of the UTOPIA Extension study, resulting in a significant intergroup difference in changes throughout the follow-up period (Table Systolic and diastolic blood pressure were significantly decreased throughout the follow-up period in the tofogliflozin group, but no significant intragroup change in blood pressure was observed throughout the follow-up period in the conventional treatment group. Although a significant intergroup difference in the changes in systolic blood pressure was observed throughout the follow-up period, no significant intergroup difference in the changes in diastolic blood pressure was observed throughout the follow-up period.