Conclusions
DBPCFC, OFC reduction
The best diagnostic test was BAT to egg in terms of diagnostic accuracy and reduction in number of OFC. Using sIgE to EW followed by BAT required fewer BATs with sustained OFC reduction and diagnostic accuracy.All participants had DBPCFC to baked egg and, if this was negative, also DBPCFC to lightly cooked egg; SPT, sIgE and BAT were performed in parallel. The test with the best diagnostic performance was BAT, followed by sIgE and SPT. Applying 100% sensitivity and 100% specificity cut‐offs allowed 100% accuracy. Using tests sequentially reduced the number of OFCs (and BATs).Abbreviations: BAT, basophil activation test; DBPCFC, double‐blind placebo‐controlled food challenge; EW, egg white; NCT, national clinical trial; OVA, ovalbumin; OVM, ovomucoid; OFC, oral food challenge; OFC+, positive oral food challenge; SPT, skin prick test; sIgE, specific IgE
Marta Krawiec, Suzana Radulovic, Ru‐Xin Foong, Andreina Marques‐Mejias and Irene Bartha shared first authors.