Conclusions
inflammation, BME, SI joints
INFLAMMATION, NR-AXSPA, JOINT INFLAMMATION
In summary, in this large study of patients with nr-axSpA, the overall level of spinal inflammation or structural damage at baseline was low. Most patients initially randomized to secukinumab or placebo showed no radiographic progression in SI joints and spine over 2 years. Secukinumab reduced SI joint inflammation (BME) in patients with active nr-axSpA which was sustained over 2 years.