Outcome data
TB, flu-like illness, malaria, hepatotoxicity
HYPERSENSITIVITY REACTIONS, MALARIA, DISEASE, FLU-LIKE ILLNESS, PERIPHERAL NEUROPATHY
Clinical outcome data will be extracted from patient records maintained by the community health teams and the clinic. Outcome variables that will be retrospectively extracted from the child contact file include presence of symptoms (binary, yes/no will be asked for each symptom), gastric aspirate/Xpert/culture results (if applicable), chest X-ray results (if applicable), the TPT or active TB treatment initiation date, the TPT regimen, planned and actual dates of all follow-up visits, TPT completion date, and reasons for early discontinuation including patient preference, pregnancy (adolescents), and severe disease including malaria or side effects including flu-like illness, hypersensitivity reactions, hepatotoxicity, and peripheral neuropathy (if applicable). We will collect information regarding the location of child contact screening, TPT initiation, and all subsequent follow-up visits. We recognize these outcomes are dependent on clinic staff compliance with study tools. Periodic monitoring of study tools will be performed, and additional training will be provided if study tools are not being used optimally.