Patients.
tumor, tumors
TUMOR, DISEASE, SOLID TUMOR, MAY, ONCOLOGY, TUMORS
Patients with an Eastern Cooperative Oncology Group (ECOG) performance status of at least 1 were eligible for enrollment if they were at least 18 years old with a metastatic solid tumor previously treated with standard-of-care therapy. Measurable disease by RECIST, version 1.1, was required with at least 2 tumors. In the initial dose–determination cohort, tumors ranging from 0.25–65 cc that were amenable to SBRT were allowed, and tumors measuring more than 65 cc were treated with partial irradiation. Patients in this cohort were enrolled between January 12, 2016 and March 3, 2017. An expansion cohort of patients with at least 1 tumor of more than 5 cm (more than 65 cc) was later opened to further explore SBRT+P in this advanced, solid tumor patient population. In the expansion cohort, patients were enrolled between December 27, 2017 and November 20, 2019. Data lock occurred on May 16, 2021.