Aim 4. Genetic relation of ARFID with psychiatric, metabolic/anthropometric, neurodevelopmental, and other relevant phenotypes
ASD, anxiety, phobic, ARFID, psychiatric, autism spectrum disorder, obsessive–compulsive disorder, OCD
To test a conceptualization that ARFID has specific genetic associations with psychiatric, metabolic/anthropometric, and neurodevelopmental phenotypes we will apply: (a) approaches as in Aim 3b, and (b) GSEM to examine genetic, psychiatric, neurodevelopmental, and metabolic/anthropometric factors associated with ARFID. We predict that high sensory sensitivity will be related to autism spectrum disorder (ASD), high levels of phobic avoidance to anxiety and obsessive–compulsive disorder (OCD), and high levels of low interest/appetite to AN. Deliverables: (a) dissection of converging and diverging relations among ARFID and other traits informing and refining its etiology; (b) genetic assessment of ARFID’s relation to other phenotypes, informing nosology.