Discussion
postoperative edema, pain, burns, trismus, platelet aggregation
TRISMUS
The results of the current study showed significantly lower BOP with Anaheal (bromelain) compared to placebo in patients who underwent pocket elimination surgery, four weeks after completion of the treatment course. Moreover, none of the patients in the Anaheal group had a GI score of 2. Also, Anaheal had a positive effect on PI, but without statistically significant difference with placebo.When compared to or used in conjunction with other anti-inflammatory medications, bromelain has been utilized in dentistry for its anti-inflammatory properties, particularly following third molar extraction [Experimental and clinical research has shown that bromelain offers a variety of benefits, such as speeding up the healing of wounds, debriding burns, and reducing pain. In addition to anti-inflammatory effects, it also possesses anti-edema, anti-coagulant, and platelet aggregation inhibitory features [The efficacy of bromelain has previously been assessed following mandibular third molar surgery. Bhoobalakrishnan et al. showed that in the treatment of postoperative edema, discomfort, and trismus, bromelain was equivalent to diclofenac [Consistent with our findings, Banihashemrad et al. showed lower but non-significant GI after periodontal surgery of pocket elimination by Widman flap technique [To our knowledge, this study is among the pioneers for the evaluation of bromelain effects after pocket elimination surgery, but it was not without limitations. We did not have an NSAID arm in our study to compare the effects of bromelain with. In addition, the sample size was relatively small which might account for the nonsignificant differences as P-values are largely dependent on sample size. Also, the small sample size can limit the generalizability of our findings. Further, we did not control the post-intervention results in terms of pre-intervention values.