Ethics approval
This randomized, double-blind, controlled study conformed to the standards of the Declaration of Helsinki and was approved by the Biomedical Research Ethics Committee of Peking University First Hospital (Ethical Committee no. 2020-426) on 5 January 2021. Written informed consent was obtained from all participants before enrollment. The current study adhered to the CONSORT guidelines and was registered prior to patient enrollment at the Chinese Clinical Trial Registry (