Graphical Abstract
fracture, chronic kidney disease, BMD loss of the 1/3 distal radius
LOW BONE MINERAL DENSITY, VITAMIN K DEFICIENCY


In patients with chronic kidney disease on dialysis treatment, low bone mineral density (BMD) is prevalent.Low BMD is associated with an increased risk of bone fracture and mortality.Vitamin K deficiency may contribute to low BMD.
In a 2-year randomised, double-blind, placebo-controlled study of patients on chronic dialysis treatment, an accelerated BMD loss of the 1/3 distal radius but preserved BMD of the lumbar spine were seen with 2 years of MK-7 supplementation compared with the changes in BMD with placebo in an intention-to-treat analysis. BMD at the other sites measured was unaffected.Vitamin K supplementation improved the vitamin K status compared with placebo.
The results of the present study indicate that MK-7 supplementation might modify BMD site-specifically in patients receiving dialysis treatment but, in aggregate, do not support MK-7 supplementation to preserve bone.