Body temperature and activity
Animals were considered to have a significant increase in body temperature (SIBT) when six consecutive measurements were above animal baseline body temperature (2 standard deviations of baseline adjusted temperatures over the average baseline adjusted body temperature). Recovery from elevated temperature (return to baseline temperature) is defined as the observation of 6 consecutive temperature measurements below the SIBT.A minority of animals (38%) in each of the placebo, 7.5 U/kg and 15 U/kg ANTHRASIL-treated groups and 25% in the 30 U/kg ANTHRASIL-treated group exhibited SIBT before treatment. Neither the proportion of animals exhibiting SIBT prior to treatment nor the time between treatment initiation and return of temperature consistent with baseline was significantly different between groups.