Trial design and ethical clearance
The present study was a prospective, randomized controlled clinical trial and adhered to the Consolidated Standards of Reporting Trials (CONSORT 2010) statement. Ethical approval was obtained from the Ethics Committee of the Medical Faculty of the University of Munich (registration no. 20-681). Informed written consent was obtained from all patients participating in this study. The investigation was conducted as a single-center study at the Department of Conservative Dentistry and Periodontology of the University Hospital, LMU Munich from October 2020 to October 2021.