3.1. Group A (the Gene Therapy Group)
necrotic lesions, ulcerations, venous by-pass, necrosis
ULCERATION, ULCERATIONS, NECROSIS
This group consisted of eight people, including five men and three women aged 59–78 years. Four people had necrosis of the toe, three people had ulceration of the foot or ankle (one case ending in major amputation), and one person had multiple necrotic lesions and ulcerations.Prior to bicistron plasmid administration, four patients had an ‘in situ’ femoropopliteal venous graft, two patients had an ‘in situ’ femoropopliteal / sagittal venous graft, and the remaining two patients had an ‘in situ’ femoropopliteal venous by-pass with profundoplasty and/or iliac axis debridement.Lesion healing in up to 12 weeks occurred in four patients (50% of the group), and above 12 weeks, there were no such cases.The ABI increased from values in the range of 0.20–0.55 to values in the range of 0.5–0.9, with an average of 0.25.TcPO2 increased from values in the range of 25–46 mmHg to values in the range of 58–91 mmHg, by an average of 30.4 mmHg.The rest of the data on the amount of classical and endovascular procedures performed in the patients, the patency of the by-pass immediately after the procedures and after 3 months, and the presence of stationary ulceration are shown in 