Criteria for discontinuing or modifying allocated interventions
Mechanic bowel obstruction, Neutropenia
NEUTROPENIA, CAVITY, LIVER, ADHESIONS
Patients can withdraw from the trial at any time by expressing their will to the study clinician. Also, different medical conditions may force them to discontinue or modify the study interventions. These include:
Mechanic bowel obstruction.Intraabdominal adhesions that prevent safe access to the abdominal cavity.Neutropenia defined by absolute neutrophil count < 1.5 × 10Thrombocytopenia: platelet count < 100 × 10Renal function insufficiency: by creatinine clearance < 50 ml/min.Liver function insufficiency: AST/ALT > 3× the upper limit of normal or bilirubin > 2× the upper limit of normal.Patients will be withdrawn from the study by the individual decision of the study clinician in consultation with the principal investigator.