2.5. Outcome Measures
INSULIN SENSITIVITY, SECONDARY, OXIDATIVE STRESS
The primary outcome measure was the change in glucose area under the curve (AUC) in response to a 75 g OGTT at week 12. The secondary outcomes included changes in body weight, body composition, systolic (SBP) and diastolic blood pressure (DBP), fasting blood lipids, high sensitive C-reactive protein (hsCRP), fasting glucose and insulin, insulin AUC in response to the OGTT, HOMA-IR, HOMA-β, Matsuda Insulin Sensitivity Index, oxidative stress (plasma F2-isoprostanes) and blood mRNA markers of autophagy (