Sacroiliac joints
edema, bone marrow edema
EDEMA, BONE MARROW EDEMA
At week 16, the mean (SD) SI joint total edema score decreased from baseline by 1.23 (2.81) in the secukinumab group vs 0.37 (1.90) in the placebo group. This reduction in BME observed at week 16 was sustained through week 104 (−1.49 [3.33] with secukinumab vs −0.40 [2.28] with placebo at week 52; −1.73 [3.49] with secukinumab at week 104) (Fig. The mean change in SI joint bone marrow edema score by MRI in the overall population and in patients with baseline score > 2 through week 104. Data presented are as observed. The secukinumab group includes patients who continued on secukinumab to week 104. The placebo group includes only patients randomized to placebo who remained on placebo to week 52. At each time point, only patients with a value at both baseline and that time point are included. MRI, magnetic resonance imaging; 