Potential targets of Polymyxin-B hemadsorption based on the derivation cohort
coagulopathy
COAGULOPATHY
By comparing the characteristics in each quintile group based on the estimated individual treatment effects, we found that patient severity scores (i.e., APACHE II and SOFA scores), parameters indicating coagulopathy (e.g., platelet, PT-INR, and FDP), and lactate could be the key determinants of treatment effects of PMX-HA (Table Kaplan–Meier curves of patients in all and targeted population of the validation cohort. Legend: Shown are unadjusted Kapan–Meier curves of patients in PMX-HA use on the targeted subpopulation of the derivation cohort had statistically significant higher treatment effects on 28-day survival (+ 9.2% [95% CI + 1.0% to + 17%], 