Accuracy of the score
SENSITIVITY
To assess the decisions for the necessity of a dose reduction (yes or no) derived from the dichotomized score, we calculated the sensitivity and specificity in the derivation and validation sets. Sensitivity was defined as the probability that a patient needing dose reduction had been correctly identified, i.e., score ≥ 1. Specificity was defined as the probability that a patient needing no dose reduction had been correctly identified, i.e., score = 0.All analyses were performed with SAS 9.4. Strict blinding regarding individual information on treatment allocation and outcome was ascertained as only one unblinded statistician performing the statistical analyses had access to the data set and all results were displayed to authors only on an aggregated basis.