Acknowledgements
BRUCE
We are grateful to all the patients and their families whose precious support allowed the conduct of this study. We are most grateful to Drs. Henry Brem, Alessandro Olivi, Antonino Chiocca, and Jeffrey Bruce for actively participating in an Advisory Board that helped determine the clinical design of this study. We also sincerely thank the members of the Safety Board, Prof. Riccardo Soffietti, University of Turin and Prof. Colin Watts, University of Birmingham, United Kingdom who reviewed the data and assisted in the evaluation of the safety profile throughout this study. We are grateful to Gandino Mencarelli, Riccardo Pracella and Amy Amata Soriano for the technical support.