Study design
We assessed changes in estimated glomerular filtration rate (eGFR), urinary retinol-binding protein/creatinine (uRBP/Cr), and urinary βWe Beyond these polymorphisms, we used a stepwise approach to prioritize sets of polymorphisms to interrogate to decrease the burden of multiple comparisons. We surmised that polymorphisms previously and strongly associated with at least one drug-related phenotype, or that have been significantly genome-wide associated with any trait, are most likely to be true associations. We explored all polymorphisms from the Pharmacogenomics Knowledgebase that were associated with any drug at levels of evidence of 1 (preponderance of evidence shows an association, replicated in multiple cohorts, and preferably with strong effect size) or 2 (moderate evidence of association, replicated but some studies may not show statistical significance, or with small effect size) (accessed 10 February 2021) [