Participants
ALLERGY TO ACETAZOLAMIDE, DISEASE
Healthy men and women aged 40 to 75 years who responded to word-of-mouth propaganda or were known to the study staff were invited to participate in this study. Participants had to live below 800 m and be free of any disease or need of medication. Subjects reporting either heavy smoking (>20 cigarettes/day), a history of smoking >20 pack-years, cessation of smoking less than 10 years ago, regular use of alcohol or a known allergy to acetazolamide or other sulfonamides were excluded.