Future studies
anxiety
The trial showed that using melatonin as a premedication was less effective at reducing preoperative anxiety than midazolam, further adding to the knowledge base within the perioperative anaesthetic field of effective anxiolytic paediatric premedications. However, given the findings of the MAGIC trial, there still remains a clinical need to develop or repurpose another premedication with a more favourable side-effects profile. A recent 2022 systematic review evaluated the sedative effects of various commonly used premedications, including: dexmedetomidine, midazolam, clonidine, ketamine, and melatonin, in managing preoperative anxiety in children (aged <7 yr).