Limitations
This study has several limitations. First, this was a post hoc analysis of the AMATERASU RCT, and the number of patients in the p53-immunoreactive subgroup was very small. Second, because analyses assessed a post hoc hypothesis, observer error or bias could have influenced results. Thus, the findings must be considered exploratory and interpreted with caution, although the main results of this study were remarkable and remained significant even after Bonferroni correction. Third, mutations of the 