Study design, setting, and mitigation strategies due to the COVID-19 pandemic
AD
In a four-armed, randomized controlled, single-center, open explorative clinical trial, adult AD patients received HTP, IFDP, EP, or control (nonintervention, waiting list, control). This study followed the standards of the Declaration of Helsinki,A randomization list was generated by a data manager as a computer-generated block randomization with variable block length. The randomization list was concealed by use of a computer interface, implemented in an MS ACCESS database and managed by the study nurse. The study physician contacted the study nurse by telephone, and after entering participants' inclusion information, participants were assigned to the respective study arm, and randomization results were reported to the study physician. The study interventions HTP and IFDP were performed at the Outpatient Clinic for Integrative Medicine at Campus Mitte Charité - Universitätsmedizin Berlin, EP was performed at the Center for Outpatient Rehabilitation (ZAR), Berlin.