Study design
This four-arm, multicentre RCT was registered in the Clinical Trials Registry (ChiCTR2200057685) and approved by the Fujian Provincial Hospital Human Research Ethics Committee (K2021-04-004). All procedures were carried out in compliance with ethical norms for human experimentation as well as the Helsinki Declaration of 1975 and its subsequent amendments. Written informed consent was obtained from all participants through an authorised surrogate decision-maker.