2.3. Omega-3 Supplementation Decreased Circulating Inflammatory Markers
To investigate intervention effects on inflammatory markers in old adults, we first assessed the circulating levels of IL-6, IL-10, IL-1 receptor antagonist (IL-1RA), c-c motif chemokine ligand-2 (CCL-2), and high-mobility group box-1 (HMGB-1) in fasting serum samples. According to unadjusted within-group comparisons before and after treatment, serum concentrations of IL-6 (Subsequent sex-stratified analyses indicated that additional omega-3 supplementation led to significantly decreased IL-10 in both women (