Pharmacokinetics
PK parameters for nofazinlimab were evaluated at pre-infusion, end-of-infusion, and end-of-infusion +30 min/+90 min/+6 h/+24 h/+72 h/+ 168 h/+ 336 h in cycles 1 and 4 and pre-dose in subsequent cycles. For regorafenib, blood samples were collected at 0 h, 3 h, 6 h and 24 h on cycle 1 days 1 and 21. Samples were processed and analyzed at a central laboratory.PK parameters evaluated included area under the concentration–time curve from the time of dosing to day 21 (AUC