3. Results
anxiety, abdominal pain, IBS-D, abdominal complaints, depressive
Both groups did not differ in clinical parameters or daily TRP consumption (We did not notice significant differences in the TRP intake in both groups; however, the urinary levels of the following TRP metabolites: 5-HIAA, KYN, and QA were higher in the IBS-D group (All IBS-D patients in both subgroups showed similar severity of abdominal complaints as well as anxiety and depressive symptoms before nutritional intervention (After nutritional intervention, TRP intake was reduced from 20.8 ± 2.10 mg/kg b.w. to 17.5 ± 2.62 mg/kg b.w. (16.2%) in Group IIA and from 21.7 ± 2.16 mg/kg b.w. to 13.09 mg/kg b.w. (39.7%) in Group IIB.In both IBS-D subgroups, a significant reduction in somatic and mental symptoms was obtained after dietary treatment (In subgroup IIB we also noticed higher number of IBS-D patients in whom the main abdominal symptoms were reduced after nutritional intervention: abdominal pain 40.5% vs. 63.2% (chi2 = 4.05, In Group IIA, no significant changes in the results of urinary excretion of TRP and its metabolites were found, while in Group IIB, 5-HIAA levels, as well as KYN and QA levels, were significantly reduced, and KYNA levels increased (Small percentage reducing TRP intake showed an inverse correlation with the degree of GSRS score improvement in both groups of IBS-D patients. After nutritional intervention the intensity of abdominal symptoms shows a positive dependence on the average amount of TRP intake in both sub-groups of IBS-D patients, The values of BMI and the caloric value of diet and the results of routine laboratory tests did not change significantly after nutritional intervention in both groups. The diet was well tolerated in both groups. However, the limited consumption of some products as part of the Polish diet, such as white bread, pasta, processed meat, and others, was not gladly accepted. The patients did not report any side effects. The compliance and cooperation between patients and dietitians were correct.