General efficacy of sirolimus within the first year.
pain
Among the 132 patients, 107 had completed 12 or more months of sirolimus treatment, 61 of whom having terminated the 2-year treatment. Among the 132 patients, 112 (85%) had a clinical improvement on sirolimus, whereas 10 patients (7.5%) never reported an improvement during the first year. Another 10 patients (7.5%) did not experience sufficient benefit within the first year.At the 12-month time point, 77% of the patients with continuous daily pain (Some patients reported an initial increase in pain compared with baseline within the first 3 months: transitory increase in continuous pain (11% and 6% of patients with and without baseline pain, respectively), increased frequency of pain exacerbations (24% and 7% of patients with and without baseline pain exacerbation), and an increase in pain exacerbation intensity (7% and 7% of patients with and without baseline pain exacerbation) (At the 12-month time point, 73% of patients with baseline functional limitation (