Conclusion
postoperative sequelae
The results showed in this split-mouth randomized clinical trial assessed that pre-operative administration of prednisone is adequate to reduce postoperative sequelae by improving patient comfort after M3M surgery with conventional/moderate surgical difficulty.Patients undergoing third molar surgery under local anesthesia may benefit from a single administration of low-dose prednisone. Furthermore, this administration route is simple, convenient, and comfortable for both patient and surgeon.The digital analysis performed in our study allowed a more objective evaluation of the facial swelling, reducing costs and possible bias.However, the authors believe that further multicenter randomized controlled trials are necessary to validate this treatment's efficacy and to extend the results at all types of M3M.