4.2. Regorafenib Treatment
toxicity
A total dose of 160 mg regorafenib was administered per os once daily following a light meal for 21 days of every 28-day cycle (i.e., 21 days on, 7 days off study treatment) until one of the criteria for treatment discontinuation was met. The dose may have been delayed and/or reduced to 120 mg or 80 mg for toxicity, but it was not to be reduced by more than two dose levels. Following dose reduction, dose re-escalation was considered (up to 160 mg) at the treating physician’s discretion, provided that the toxicity had resolved to baseline.