Author contributions
DO, IC, CJ, MMG, CJB, and AJP conceptualized the study, and DO supervised the study. DLC, LB, EJ, and JH performed the laboratory work. HZ, IC, and DO performed the in silico analysis. JT and DFK reviewed and improved the in silico analysis. AJP acquired funding. HZ, IC, and DO wrote the original draft of the manuscript. All authors critically reviewed and approved the final version of the manuscript. All authors had full access to all the data in the study and had final responsibility for the decision to submit for publication. HZ and IC are listed as co–first authors on the basis of their equal contributions to the work.