Study design.
obesity
OBESITY
Seventeen men and women with obesity were admitted as inpatients to the Metabolic Clinical Research Unit at the NIH Clinical Center. They completed fMRI and PET scans on the third day of a 5-day inpatient eucaloric baseline diet, after which they were randomized to either a 30% reduced-calorie diet achieved by selective restriction of dietary fat (RF diet) or carbohydrate (RC diet). Neuroimaging was repeated on the fifth day of the reduced-energy diet, after which, on days 12–14 of the inpatient stay, participants consumed food ad libitum from vending machines. After a 2- to 4-week washout period, participants were readmitted as inpatients to complete the 5-day eucaloric baseline diet, and neuroimaging was repeated on the fifth day of the alternate 30% reduced calorie diet. During the final 3 inpatient days, participants again consumed food ad libitum from vending machines.