RFM/CPAP intervention study
CRAE, stroke, OSA, CRVE, SDB
STROKE
When a sub-group with a wide range of SDB severity were individually stabilised on medical therapy, monitored and given CPAP therapy over a 12 month period, there was no change in group mean evening CRAE or CRVE values or the overnight change in CRAE or CRVE. However, evening CRVE values tended to decrease over the CPAP period, especially for those with more severe SDB (AHI>30 events/hr; see In summary, treatment of OSA with CPAP (combined with medical treatment to control lipid levels and blood pressure) had some effect over 12 months in reducing evening CRVE, and thus perhaps reducing stroke risk. However, this change was not dependent on the amount of CPAP used, and therefore may reflect the impact of all the medical interventions aimed at reducing/stabilising vascular risk factors, rather than the elimination of SDB.