Study procedure
T2DM
DISEASE
This double-blind randomized clinical trial was conducted on T2DM patients who were referred to Motahari hospital in Shiraz city, Iran. In the beginning, a participant's disease was diagnosed with the help of an endocrinologist. Then, the study procedure was explained to the participants and informed written consent was obtained from all. After that, the participants entered a two-weeks run-in period. During the run-in time, they had to stop taking any soy product, probiotics food or probiotics supplements. After the run-in time, the patients were randomly allocated to 4 groups using the software as follows; group 1; received soymilk (240 cc) + probiotics capsule, group 2; received soymilk + placebo capsule, group 3; received conventional milk (240 cc) + placebo capsule, and group 4; received probiotics capsule. Also, each participant's energy intake was calculated using the estimated energy requirement formula, and the weight stability diet was written for all of them. Energy distribution for all subjects consisted of 55% carbohydrate, 18% protein, and 27% fat. In group 4, the energy that groups 1 and 2 received through soymilk was compensated through other food groups. All patients were asked to maintain their usual diet and physical activity throughout the study period.