Least-squares mean change in Sleep NRS score over time to week 24 in PRIME (a) and PRIME2 (b).
Data are presented as mean values ± SE. Each of the imputed complete data were analyzed by fitting an ANCOVA model with the corresponding baseline value, intervention group, documented history of atopy (atopic/non-atopic), stable TCS/TCI use (yes/no), region and baseline antidepressant use (yes/no) as covariates. 
