Sample Size
DRY EYE, GROUP B
In the pre-experiment, 10 patients who applied Vitamin A palmitate eye gel got an effective rate of 60% in improving dry eye while 10 who applied 0.1% sodium hyaluronate eye drop got 30%. We let the inspection level α = 0.049, inspection efficiency 1- β = 0.80. Considering the possible loss of follow-up rate as 20%, the total sample size of this study was 80 and 40 in each group.In this study, 80 patients (80 eyes) were randomly divided into Group A and Group B by the envelope method. Vitamin A palmitate eye gel was applied in Group A three times/day, one drop each time. Group B was given 0.1% sodium hyaluronate eye drop three times/day, one drop each time. The effect was evaluated 1 month after drug administration. During the treatment, other topical eye drugs were not allowed.The following data of subjects were collected at baseline and after 1 month of treatment. In consideration of the actual situation, clinical data were collected three days before or after one month was allowed. Generally, gel or eye drops were not used on the day of measurement, and the measurement time was at the same time of the day at baseline or post treatment.