Assessment of immune dysfunction in critically ill patients
critically ill, nosocomial infection
CRITICALLY ILL, NOSOCOMIAL INFECTION
In the present study, the potential immune effects of L-citrulline administration and higher plasma L-arginine were explored by measuring validated biological markers. IL-6 is considered a reliable marker of illness severity, and monocytes express HLA-DR molecules, which are responsible for antigen presentation to T cells and are a validated marker of immune function associated with the risk of nosocomial infection acquisition and mortality in critically ill patients [