Background
compulsions, obsessive thoughts, chronic mental disorder, Obsessive-compulsive disorder, psychiatric, DSPD, repetitive behaviors, OCD
DISORDER, PATHOPHYSIOLOGY, DELAYED SLEEP PHASE, DISORDERS
Obsessive-compulsive disorder (OCD) is a chronic mental disorder characterized by obsessions, compulsions, or both. It presents with recurring, unwanted, and intrusive thoughts, images, or urges (obsessions) that may lead to repetitive behaviors and mental acts suppressing the distress caused by obsessive thoughts (compulsions). OCD is one of the most common psychiatric disorders, and its lifetime prevalence is 2.3% among the general population [Currently, the first-line treatment of OCD includes selective serotonin reuptake inhibitors (SSRIs), clomipramine, and cognitive-behavioral therapy (CBT) [The pathophysiology of OCD is not yet fully understood. Although, hormonal dysregulation and delayed sleep phase disorder (DSPD) in patients with OCD point to the possible role of abnormal circadian rhythms [Agomelatine is a selective melatonin receptor (MTWe conducted this randomized, double-blinded, placebo-controlled, parallel-group clinical trial to assess the efficacy and safety of agomelatine augmentation of sertraline in the treatment of patients with moderate to severe OCD.