Limitation
In this study, the combination of propofol and remimazolam tosylate was used, a dose escalation test was conducted in a pre-experimental by the sequential method in the selection of the dose of the two combinations, and the MOAA/S≤1 for remimazolam 0.1 mg/kg+propofol 0.5 mg/kg could be satisfied., the dose was not tested with a large sample size and may not be the optimal dose for the combination of the two drugs. Therefore, the optimal dose needs to be further investigated.