Tolerability
vertigo
TOLERANCE
A total of 80.6% (87) of the patients were tolerant to the prescribed dose with the distribution of 8% (7/87) on 50 mg BID, 28.7% (25/87) on 100 mg BID, and remaining 63.2% (55/87) on 200 mg BID. A total of 21 (19.4%) patients required either down titration or temporary discontinuing of the prescribed medication, 10 patients due to increase complained of vertigo, 5 patients got symptomatic, 3 patients due to increase in creatinine level, and 3 patients due to increase in potassium level. Tolerance was observed to be unaffected by the demographic and baseline characteristics of the patients, shown in Table Comparison of tolerability and safety measures during 12-weeks of therapy by various baseline and demographic characteristics*Significant at 5%