Safety
ascites, bloating, myalgia, dyspnea, nausea, diarrhea, toxicities, anemia, weight gain, pruritus, insomnia, Nausea, palmar-planter erythrodesstheia syndrome, abdominal bloating
ADVERSE EVENTS, ASCITES, ANEMIA
There were no grade 3 or 4 serious adverse events in this study. However four out of eight patients had one of the following adverse events (regardless of attribution to naltrexone), including weight gain, myalgia, insomnia, dyspnea, pruritus, palmar-planter erythrodesstheia syndrome, hot flashes, anemia, ascites, bloating, nausea, diarrhea, and elevated AST. Nausea, abdominal bloating, diarrhea, and elevated AST were at least possibly attributed to study drug. One patient discontinued therapy for grade 2 hot flashes, but there were no discontinuations of naltrexone due to grade 3 or 4 toxicities. One patient chose to discontinue therapy for grade 2 hot flashes.