1. Introduction
gastric cancer, cancer, Cancer
GASTRIC CANCER, INFLAMMATORY RESPONSE, INFLAMMATION, CANCER, GASTRIC CANCER, MALIGNANCIES, COMPLICATIONS, CANCER
These authors contributed equally to this work.Objective: The impact of perioperative immunonutrition on patients undergoing radical gastrectomy remains undetermined. This study aimed to assess the influence of enteral immunonutrition support on postoperative immune function and intestinal mucosal barrier function following radical gastrectomy, contrasting findings with a control group to furnish evidence for perioperative enteral nutrition support. Methods: In this prospective randomized trial, 65 patients who underwent radical gastrectomy between June 2022 and June 2023 were included. Participants were allocated to either the study group (receiving enteral immunonutrition) or the control group (not receiving enteral immunonutrition). We compared postoperative rehabilitation and complications between the groups, analyzed the intestinal mucosal barrier function markers on the 3rd and 7th postoperative days, and delved deeper into peripheral blood cell immunity, inflammation, and nutritional indicators. Results: The cohort consisted of 30 patients in the study group and 35 in the control group, with no significant differences in demographic attributes between the two groups. On the 3rd postoperative day, the diamine oxidase, D-lactic acid, and endotoxin levels in the study group were significantly lower than those in the control group (Gastric cancer stands as one of the predominant malignancies of the gastrointestinal system. According to the Global Cancer Statistics 2020, it is the fifth most common cancer globally regarding incidence, and is ranked fourth in mortality [In this pioneering endeavor, we gauge the ramifications of perioperative enteral immunonutrition (EIN) administration on postoperative recovery trajectories following gastric cancer surgery by meticulously assessing indicators reflective of the function of the intestinal mucosal barrier. We juxtapose these findings against a control group receiving enteral nutrition (EN) devoid of immunonutrients. Our overarching objective is to discern the differential impacts of these nutritional support treatments on postoperative inflammatory response, immune function, and intestinal barrier function, thereby crafting an evidence-based foundation for perioperative nutritional interventions in gastric cancer.