Patients
PONV, colorectal cancer, postoperative adverse reactions, cognitive dysfunction
ADVERSE REACTIONS, INFLAMMATION, COLORECTAL CANCER, BLOOD
In our study, 160 eligible patients who underwent laparoscopic radical resection for colorectal cancer in our hospital from February to November 2022 were randomized. A total of 10 patients (10/160) dropped out of the group for various reasons (7 patients in the lidoc aine group and 3 patients in the control group) (Fig. 
Baseline characteristics of the two groupsASA: American Society of Anaesthesiologists. mean ± standard deviation (SD); median (IQR); n(%)
Study flow diagramThe results for the main study outcomes are shown in Table 
Comparison of perioperative MMSE scores between the two groupsRate of POCD(Postoperative MMSE score decreased by ≥ 2)POCD: postoperation cognitive dysfunction; MMSE: Mini-mental State Examination. median (IQR); n(%)
Comparison of the perioperative MMSE scores between the two groupsIn terms of intraoperative maintenance drugs(Sevoflurane, Propofol, and Remifentanil), We found non-significant trends between the two groups after adjusting the duration of anesthesia and weight(
Comparison of intraoperative medication and adverse reactions between the two groupsmedian (IQR); n(%)By comparing the perioperative inflammation between the two groups, it was found that there was non-significant trends in preoperative white blood cell count between the two groups(
Markers of postoperative inflammation between the two groupsWBC: White Blood Cell; CPR: C-reactive protein. mean ± standard deviation (SD)For the comparison of postoperative recovery, we paid attention to the resuscitation room, postoperative adverse reactions and length of hospital stay of the two groups. The above mentioned results were non-significant trends between the two groups (
Comparison of postoperative recovery between the two groupsPACU: Postanaesthesia care unit; PONV: postoperative nausea and vomitingmedian (IQR); n(%)