Factors involved in high fecal secBA levels
colorectal motility, colon cancer
FUNCTIONAL CONSTIPATION, COLON CANCER
We found high fecal secBA levels to be associated with fewer “normal” bowel movements and a higher intake of animal fat. A randomized controlled-feeding trial of healthy young adults showed that consuming a high-fat diet for 6 months increased fecal secBA levels [High-secBA cluster members, who presumably produced more secBAs, were at increased risk of colon cancer [Our study had some limitations. First, its cohort was relatively small and consisted mostly of female. Fecal BA levels were not significantly different between males and females (data not shown), but sex differences in colorectal motility and the prevalence of functional constipation have been reported [