Treatment and procedures
Patients were randomized 1:1 to receive subcutaneous dupilumab 300 mg (loading dose of 600 mg on day 1) or matching placebo every 2 weeks for 24 weeks. Patients on a stable regimen of low-to-moderate potency TCS and TCI before screening were allowed to continue their use throughout the trial. Patients on stable doses of antidepressants for 3 months before enrollment were eligible, provided they planned to keep medication unchanged throughout.