2.2. Patients
PJI
STAPHYLOCOCCUS
The study was based on analysis of outcomes in 45 patients with deep PJI of the hip joint, treated at the Novosibirsk Research Institute of Traumatology and Orthopedics between 2012 and 2018. Informed consent was obtained from all subjects involved in the study. The study design, and patient disposition within intent to treat (ITT) and per protocol populations (PP), are shown in The Informed consent for surgical treatment.Patients of any gender aged from 18 to 70 years.Clinically and laboratory confirmed signs of early post-operative, late chronic, or acute hematogenous PJI, according to previously published classification [Anatomical conditions for cemented endoprosthesis implantation (the possibility of cement pressurization): anatomical bone defects of the proximal femur type I or II according to the Paprosky classification [General somatic condition of the patient being suitable for elective surgery in the form of a one-stage treatment of deep PJI according to the clinical guidelines of 2013 [In vitro determined susceptibility of the isolated staphylococcus bacteria to a staphylococcal phage preparation with a titer of at least 10Eligibility of the patient for the phage therapy protocol within the first ten days after revision surgery.The Patients under the age of 18 and over 70 years.The absence of the main signs of PJI in the patient according to the MSIS criteria [A lack of anatomical conditions for cemented endoprosthesis implantation (the possibility of cement pressurization): pronounced anatomical bone defects of the proximal femur type IIIA, IIIB, or IV according to Paprosky [PJI of non-staphylococcal etiology.Life-threatening conditions requiring urgent surgery before revision arthroplasty.Lack of sensitivity of isolated The Life-threatening conditions requiring urgent surgery within 12 ± 2 days after completed revision arthroplasty;Lack of sensitivity of isolated staphylococcus bacteria to a staphylococcal phage preparation, defined as a bacteriophage titer less than 10