Endpoints
INSULIN RESISTANCE
(1) Glucose metabolism indices. Fasting postprandial glucose(FPG) and 2-hour postprandial glucose(2HPG) levels were measured using a glucose meter before treatment and after 24 weeks of treatment in both groups. Patients’ glycosylated hemoglobin (HbAlc) levels were measured using an automatic biochemical analyzer ((2) Biochemical index and insulin resistance index (Homa-IR). The levels of visceral adiponectin were measured by enzyme-linked immunosorbent assay (2). Leptin (Lp) levels were measured by radioimmunoassay. Fasting-insulin (FINS) was measured by a fully automated immunoluminescence analyzer and HOMA-IR (HOMA-IR=FPG*FINS∕22.5) levels were calculated ((3) Cost-Effectiveness Ratio (CER). The economic value analysis contained two aspects: cost determination and efficacy analysis. A cost-effectiveness ratio (CER) was performed, where the lower CER indicates the better economic value (