PFS2 in patients in first-line subgroup
DISEASE PROGRESSION, PROGRESSION
Following study treatment in the first-line setting, 130 of 237 patients (54.9%) in the ribociclib arm and 93 of 128 patients (72.7%) in the placebo arm had disease progression while receiving subsequent therapy. The median PFS2 was 16.1 months longer in the ribociclib arm (50.7 months; 95% CI 42.1–58.9 months) versus the placebo arm (34.6 months; 95% CI 29.9–42.6 months [HR 0.64; 95% CI 0.49–0.84]; Fig. Progression free survival 2 in patients who received ribociclib plus fulvestrant as first-line therapy