Author Contributions
Conception and design of the research: M.E.S., A.A.-Á. and G.B.; acquisition of data: A.A.-Á., R.C.-S., I.P.-T., O.G.-M. and J.F.-G.; participation in patient enrolment, patient UCI, procedures, and sample collection: A.A.-Á., R.C.-S., R.M.-V., S.C.-A., L.M.-P. and J.F.-G.; statistical analysis and interpretation of data: M.E.S., A.A.-Á., H.S.-O. and R.G.; writing of the manuscript: M.E.S., A.A.-Á., I.P.-T. and G.F.-Á.; critical revision of the manuscript for intellectual content: M.E.S., I.P.-T., G.F.-Á. and V.G.-L. All authors have read and agreed to the published version of the manuscript.