Effect of secretin on inhibitory neural responses
CORTEX, BRAIN
Compared to placebo condition, secretin condition was associated with faster reaction speed in Go trials while including both “go” or “rare go” trials as go trials in the analysis (Brain BOLD signals in no go versus go trials were associated with elevated activity in insula, supplementary motor area, precentral gyrus, postcentral gyrus, anterior and middle cingulate cortex, precuneus, and thalamus in the placebo conditions (Fig. Secretin modulated the inhibition related neural activity (Meanwhile, dampened activity was found in lateral and medial prefrontal cortex and posterior cingulate area in both conditions (Fig. Our findings so far have revealed that secretin (i) stimulates metabolic crosstalk between BAT and caudate, (ii) increases brain BOLD signals in inhibitory control, and (ii) reduces BOLD response to appetizing food pictures (supplementary Fig. 