2.4. Evaluation of Cognitive Function
FTT
The Cognitrax test (Health Solution, Inc., Tokyo, Japan) was used to assess the cognitive function of the participants after the intervention. It consists of a computerized test battery that evaluates multiple cognitive domains, including composite memory, verbal memory, visual memory, processing speed, psychomotor speed, executive function, reaction time, complex attention, simple attention, cognitive flexibility, and motor speed. The Verbal Memory (VBM) and Visual Memory (VIM) tests are adaptations of the Rey Auditory Verbal Learning and the Rey Visual Design Learning Tests. The total number of correct answers on VBM and VIM becomes the memory aggregate score or the memory area score. Psychomotor speed is obtained from the sum of the left and right finger taps of the Finger Tapping Test (FTT) and the sum of the number of correct answers to the Symbol Digit Coding (SDC). FTT is one of the core tests of the Halstead–Reitan Battery, whereas SDC is based on the Symbol 3 Digit Modalities Test, a variant of the Wechsler digit symbol substitution test. Within the Central Nervous System Vital Signs (CNSVSs), the Stroop Test (ST) averages the two complex reaction time scores from simple and complex reaction times to obtain a score in the “reaction time” domain. From this domain, the “information processing speed” is also obtained. The Shifting Attention Test (SAT) measures a subject’s ability to respond quickly and accurately from one instruction to the next. The Cognitive Adaptability domain score is the number of correct answers on the SAT minus the total number of incorrect answers on the SAT and ST. The Continuous Performance Test (CPT) measures sustained attention. The domain score for total attention is the sum of the number of incorrect responses on the CPT, SAT, and ST. We used stimuli from the “stores” of words and shapes in the test (VBM, VIM, SDC). Reaction times were recorded with millisecond precision in the test (VBM, VIM, FTT, ST, SAT, CPT).Cognitrax scores have been standardized according to results from a large population of participants aged 7–90 years [