Randomization
A randomization schedule with a 1:1 ratio of assignment to 3RP-NF and HEP-NF, stratified by NF type using a permuted-block design, was constructed by the unblinded biostatistician (E.M.) and managed with REDCap. A clinical research coordinator randomized up to 16 participants as a cohort and subsequently scheduled a treatment session time. Because not all participants could join the same session time, group sizes were uneven (median, 8 [range, 3-8]). Participants were told that they would participate in 1 of 2 stress and symptom management programs (program 1, intervention; program 2, control) to maintain blinding and scientific rigor.