Statistical analysis
SPSS 26.0 (Chicago, IL, USA) statistical software was used to process the data, and general data were statistically described using frequency and percentage. Chi-squared test was used for binary variables. After the continuous variables were tested by Shapiro-Wilk test, the data with normal distribution were used independent-sample t-test between the two groups, expressed as the mean ± SD. Data conversion was performed on the data with non-normal distribution, and the data with normal distribution after the conversion adopted the independent sample t test, and the data without the normal distribution after the conversion adopted the Mann–Whitney U test, which was expressed as median (IQR (range)). Multiple measurements at different time points were compared using ANOVA of repeated measurements. All tests were calculated with two tails, 