References
REGRESSION, LENS
Comparison of CBD plasma concentrations at timepoints 2 (2.5 weeks after CBD ingestion) and 3 (5 weeks after CBD ingestion) stratified by sex (female—F and male—M). Box plots show the median, interquartile range (box), and total range (whiskers). Average values are connected by lines (N = 62).A graphical representation of the results of a linear regression analysis of pairs of dependent and independent variables: The concentration of CBD is represented by the dependent variable on the y axis, while the proportion of adipose tissue in female (F) and male (M) participants is represented by the independent variable on the x axis (N = 62).Comparison of CBD plasma concentrations at timepoints 4 (after washout), 5 (2.5 weeks after placebo capsule ingestion), and 6 (5 weeks after placebo capsule ingestion), stratified by sex (female—F and male—M). Box plots show the median, interquartile range (box), and total range (whiskers). Average values are connected by lines (N = 31).The Mann–Whitney test was used to compare the concentrations of CBD, 7-OH-CBD, and 7-COOH-CBD (ng/mL) in females (F) and males (M) at three different timepoints (4—after washout, 5—2.5 weeks after placebo capsules ingestion, and 6—5 weeks after placebo capsule ingestion). Box plots show the median, interquartile range (box), and total range (whiskers). Statistical significance is defined as A graphical representation of the results of a linear regression analysis of pairs of dependent and independent variables: The concentration of CBD is represented by the dependent variable on the y axis, while the proportion of adipose tissue in female (F) and male (M) participants is represented by the independent variable on the x axis (N = 31).Research design. DehydraTECH™2.0 CBD (225 to 300 mg split over three times daily for the initial 2.5 weeks and 375 to 450 mg split over three times for the following 2.5 weeks). Participants repeated tests for a further five weeks under varied circumstances after a two-week washout. Three times in each study arm, participants visited the laboratory on a total of six occasions, each after an overnight fast.Descriptive statistics for the CBD concentrations and metabolites 7-OH-CBD and 7-COOH-CBD in plasma and urine samples and plasma ratio. The findings only apply to samples taken after ingesting CBD at two different timepoints after 2.5 and 5 weeks. Timepoints 5 and 6 for Group I and timepoints 2 and 3 for Group II. In the following text, we will refer to them as timepoint 2 (2 or 5—after 2.5 weeks) or timepoint 3 (3 or 6—after 5 weeks). N = 62.Abbreviations: CBD, cannabidiol; 7-OH-CBD, 7-hydroxy-CBD; 7-COOH-CBD, 7-carboxy-CBD; IQR, interquartile range.Descriptive statistics for the CBD concentration and metabolites 7-OH-CBD and 7-COOH-CBD in plasma and urine samples at timepoints 4–6 (2.5 and 5 weeks after placebo capsules ingestion). The results refer only to Group II participants (N = 31) for which samples were collected while taking placebo capsules.Abbreviations: CBD, cannabidiol; 7-OH-CBD, 7-hydroxy-CBD; 7-COOH-CBD, 7-carboxy-CBD; IQR, interquartile range.Antropometric summary and descriptive statistics of participants.Data presented as minimum, maximum, median, and interquartile range (IQR).Quantitative and qualitative transitions used for analysis of CBD and its metabolites.Abbreviations: CBD—cannabidiol; 7-OH-CBD—7-hydroxy-CBD; 7-COOH-CBD—7-carboxy-CBD; Q1—precursor ion; Q3—product ion (a—quantifying, b—qualifying); RF—focusing lens voltage; CE—collision energy; RT—retention time.Quantitative and qualitative transitions used for analysis of CBD and its metabolites.Abbreviations: CBD—cannabidiol; 7-OH-CBD—7-hydroxy-CBD; 7-COOH-CBD—7-carboxy-CBD; LOD—limit of detection; LOQ—limit of quantification; R