Protocol of MD
The MD protocol of this study was based on the recommendations of Bedard et al. [As a result of the above-designed MD protocol, the meal plan consisted of around 50% carbohydrates (the main source for carbohydrates was legumes, vegetables, fruits, and whole-product grains), 35% fats (the main source for fats was healthy oils, nuts/seeds, and fish), and 15% proteins (the main source for proteins was nuts, egg, poultry, low-fat dairy products, legumes, and fish).Based on the total daily requirement and degree of DE-participant’s activity (2000 kcal/d for ♂ and 1600 kcal/d for ♀), a calorie restriction of about 15% from the daily Kilocalories was proposed.During the 6-month research period, weekly consultations with a nutritionist were used to give nutritional counseling. The weekly visit was a chance for the nutritionist to assess patients ' diet adherence. All DE participants were taught how to complete a 24-h recall dietary evaluation of consumed foods, which was examined at each face-to-face nutritional session with the nutritionist.