2.5. Statistical Analysis
We analyzed all available data by treatment allocation, following the principles of intention to treat.All statistical analyses were performed using SPSS (version 26, IBM, Armonk, NY, USA), with a significance set at We used baseline characteristics as the mean and compared them to the standard deviation or the frequency count between the groups using Student’s Repeated-measures ANCOVA with years of education as a covariate was used to determine whether differences in all outcome measures existed between values (two levels for the time factor: pre- and post-trial) for each group (group factor: DOTP and placebo groups). When the interaction was significant, we examined the effect of time on each group. When the interaction was not significant, we tested the main effects of time and group. We calculated outcome measures of pre- and post-trials with a 95% confidence interval. The effect sizes (Cohen’s 