Discussion
cancer, insidious, CNV
REGRESSION, RECURRENCE, METASTASIS, CANCER, PANCREATIC CANCER, MALIGNANT TUMOR
As a highly malignant tumor, surgery is the main treatment for pancreatic cancer. However, due to the insidious onset of pancreatic cancer, lack of specific markers, and the susceptibility to early metastasis, patients with PCa often deprived of surgery once they are detected. At the same time, the postoperative recurrence rate is extremely high and the overall survival rate remains lowExtensive data show that CNV is strongly associated with cancer developmentTo further explore the role of disulfidptosis signature in PCa, we obtained five key genes from DEGs between the two disulfidptosis subtypes by screening with Lasso–Cox regression analysis: UCA1, FNDC3B, MYBL2, NHS, CCDC15. Predictive risk signature based on these five key genes were constructed. Among them, UCA1 regulates the growth and metastasis of PCa through the adsorption of miR-135aBased on these findings, we attempted an immune correlation analysis in the risk signature using the CiberSort algorithm. B cells, T cells, and monocytes were found to be more abundant in the LDR group, while regulatory T cells, activated NK cells, M0 macrophages, activated dendritic cells, and neutrophils were more abundant in the LDR group. An increased proportion of tumor-infiltrating regulatory T cells is associated with shorter survival in patients with PCaHowever, this study still has some shortcomings and limitations. Firstly, although this study has been validated using several independent cohorts, more independent cohorts and larger sample sizes are needed for subsequent validation. Secondly, we did not further investigate this gene set in other cancer types due to limited conditions. Also, the clustering algorithm used in this study is relatively homogeneous, and subsequent iterative validation of more personalized grouping algorithms, such as multidimensional scaling (MDS)-based clustering