Study design and treatment
nausea and vomiting, fever, pain
This was a multicenter, open‐label, single‐arm study designed to confirm the efficacy and safety of MD‐110. The study design is shown in Figure Study design. TC, docetaxel and cyclophosphamide. Medications that affect the efficacy and safety evaluation of MD‐110 were prohibited during the study. Antibiotics, antimicrobials, antipyretic analgesics, and traditional Chinese medicine were permitted for a fever over 37.5°C or pain. Corticosteroids were also permitted to prevent nausea and vomiting caused by TC chemotherapy.