Sample size calculation
Sample sizes for the trial, Note that these are the correct values of The same 5000 sample sizes for 5-year trials obtained from steps 1 and 2 above are used for each of the different treatment effect options, to minimise the computation time required for the simulations, and similarly for the 5000 3-year trial sample sizes. The distribution of sample sizes is therefore the same for all treatment effects, within each mean trajectory, for each of the trial lengths.