Author’s contributions
MM
RECRUITMENT
LLL was involved in drafting the manuscript. NP, KS, KMS, AM, SY, YK, YB, LC, MM, TBS, TA, CO, NT, HC, SR, KL, JZ, TP, JS and DG have made substantial contribution to conception and design and helped to draft the manuscript. AJ and WH provided central coordination, management and helped to draft the manuscript. SY designed translational sub studies and helped draft the manuscript. AM and VG were involved in the statistical consideration of the study and helped draft the manuscript. NP, KS, KMS, YK, YB, LC, MM, TBS, TA, CO, NT, HC, SR, KL, JZ, TP, JS, DG provided study data through recruitment of patients. LLL, NP, KMS, NT, JZ, DG, TP, SY and AJ are members of the Trial Management Committee. All authors have read and approved the final manuscript.