Ketamine-induced dissociative depersonalization relieves negative brain states assessed by anterior insula activity
dissociative depersonalization
We only tested for mediation effects comparing the 0.5 mg/kg and the placebo conditions, as the 0.05 mg/kg dose did not induce significant change in any mediators or in the neural activity of the right anterior insula or amygdala. Similarly, we only included activity in response to threat faces (and not happy faces) in mediation models, because only the response to threat faces showed a significant difference between the 0.5 mg/kg and the placebo condition. Our mediation analysis indicated that an increase in dissociative depersonalization negatively mediated or suppressed the effect of ketamine on task-evoked right insula activation in response to threat faces relative to neutral faces (Fig. 