Trial Design
ONCOLOGY
This multicenter, single-blind, parallel-arm, randomized controlled trial (RCT) (Fig. Study designThe study was conducted in accordance with the guidelines of the Declaration of Helsinki and approved by the Ethics Committee of the Leiria Hospital Center, District Hospital of Santarém, District Hospital of Figueira da Foz, and Portuguese Oncology Institute of Coimbra (protocol code TI 36/2021, 18 November 2021). This study is reported according to Consolidated Standards of Reporting Trials (CONSORT) guidelines.