Authors’ contributions
MM, ARF
ARF
WB and AF conceptualised the study. KB, WB and AF drafted the manuscript. MM and KB coordinated and supervised the study, contributed to sample collection and assessment of clinical data and approved the final manuscript as submitted. WB developed the analytical techniques, supervised the analyses, contributed to sample collection, drafted and reviewed the manuscript, and approved the final manuscript as submitted. AS prepared the samples, and carried out the mass spectrometry analyses. CW critically revised the manuscript making important contributions, and approved the final manuscript as submitted. CFP supervised the project as the head of department, revised the manuscript for important intellectual input and approved the final manuscript as submitted. ARF, the co-coordinator of the project, was responsible for concept and design, contributed to sample collection and the assessment of clinical data, revised the manuscript and approved the final manuscript as submitted.