Study Cohort
HCC
A total of 308 938 patients with HCC between 1999 and 2017 were identified from the NHIRD, after excluding 9173 patients with HCC diagnosis before January 1, 1999. For the comparison of antidepressant use before HCC diagnosis, we identified 21 202 patients with antidepressant exposure within 1 year before HCC diagnosis, and we had a nonuser group of 287 736 individuals. For the comparison of antidepressant use after HCC diagnosis, we identified 66 211 patients with antidepressant prescriptions after HCC diagnosis, and there were 235 083 nonusers in the comparison group (