Discussion
postoperative hip pain, blood loss, postoperative blood loss, coagulation dysfunction, pain, Opioid abuse, THA
BLOOD LOSS, PERIOPERATIVE COMPLICATION
Currently, there remains controversy regarding the perioperative use of TXA in THA, and few studies investigated the effect of TXA on postoperative hip pain in patients undergoing THA. Opioid abuse is currently a medical concern due to pain after total hip replacement [In order to promote the rapid recovery process of patients after surgery, pain management is an important part that cannot be ignored. THA is one of the most common joint replacement surgeries in orthopedics, and numerous studies have been focused on reducing the amount of opioids used during the perioperative period [Previous studies [Since the generation and perception of pain is a complex physiological process, above studies have drawn different conclusions. In clinical treatments, pain is a multifactorial associated symptom. In previous studies [As the most common perioperative complication of THA, blood loss has received extensive attention. Standardized blood management has great benefits for early postoperative rehabilitation and functional exercise of patients. As an antifibrinolytic drug, TXA has been confirmed to reduce postoperative blood loss and the rate of blood transfusion in many studies over the past decade [The strength of this study is that it is a prospective randomized controlled trial to compare the VAS score three days after surgery between the two TXA methods, combined with CRP, IL-6 and ESR levels for a comprehensive assessment. However, this study also has some limitations. First, all patients were treated with oral tramadol sustained-release tablets if the conventional analgesic treatment was not effective, but not all patients were sensitive to this drug; second, patients with coagulation dysfunction, such as taking aspirin, were not included. It has been confirmed that TXA is also safe and effective in patients taking aspirin for a long time [