Factors associated with different dose-tapering patterns
schizophrenia, schizophrenia-spectrum psychotic disorder
REGRESSION
Univariate logistic regression analyses of factors associated with each trajectory revealed that a history of relapse was significantly associated with the category of conservative reducer (odds ratio (OR): 4.64, 95% confidence interval (CI): 1.25–17.25, Univariate logistic regression analyses for factors related to designated trajectoriesAbbreviations: All 6 FR patients were with the diagnosis of schizophrenia.Statistics with Multivariate logistic regression analyses for factors related to designated trajectoriesAbbreviations: Statistics with Multivariate analysis showed that the relationship between history of relapse and being a conservative reducer was more pronounced (OR: 11.20, 95% CI: 2.012–62.37, Only 6 failed reducers were identified in this cohort, all with a diagnosis of schizophrenia yet no other variable was found to be significantly associated with relapse during dose tapering. Multivariate logistic regression analyses showed that the model composed of younger age, lower baseline antipsychotic dose, higher baseline PANSS score, higher personal social functioning, better quality of life, and having a full-time job was significantly associated with relapse during drug tapering (LR χUnivariate logistic regression also failed to find any demographic or clinical variable with a significant impact on the chance of being a sequential reducer. The model with the lowest probability as checked by LR Chi2, composed of a lower baseline PANSS score, lower medication satisfaction, with a diagnosis of other schizophrenia-spectrum psychotic disorder, and higher quality of life, was still not significantly predictive for indicating a sequential reducer (LR χ