Subgroups of Interest
stroke, upper limb impairment, infarct
STROKE, INFARCT
We identified the following variables of interest: reported age, sex (male vs female), country of enrollment (UK vs USA), severity of upper limb impairment, time since stroke, paretic side (right vs left) and whether there was cortical involvement of the index infarct. Severe upper limb impairment, time from stroke and age were dichotomized based on whether the baseline value was above or below the median (FMA-UE score of 34, time from stroke 2 years and age 62 years). Presence of cortical involvement was visually confirmed by a trained image analyst using data from the study specific MRI performed before VNS device implantation.