Active/interventional group
VIRUS
TAC trough level target range will be adapted by TTV load. TAC is approved for its intended use in this clinical study by all national competent regulatory authorities of the participating countries, and TTV load will be quantified in peripheral blood EDTA plasma by a CE-certified kit (TTV R-GENE®, bioMérieux, France) [The intervention itself is restricted to a novel dosing strategy for TAC according to TTV load. TAC dosing according to the TTV target load is detailed in Fig. Tacrolimus (TAC) dosing during the interventional phase of the TTVguideIT study: In the active/interventional group, the tacrolimus trough level range will be adapted by torque teno virus (TTV) load. The target TTV load ranges from 4.6 log