Comparison of the predictive performance of the risk stratification from the radiomic model and KRAS status for lung metastasis
RS
LUNG METASTASIS, REGRESSION, METASTASIS
Furthermore, we tested whether the KRAS status predicted and stratified by our radiomic model could represent or substitute the actual KRAS status in predicting metastasis. The association of the risk stratification (high radiomic score group or low radiomic score group) with metastasis occurrence was investigated. Then, whether a significant association with lung metastasis existed was explored by Kaplan‒Meier survival analysis, Cox regression analysis and time-dependent c-index. Finally, the predictive performances of the model stratifying risk or actual KRAS status for lung metastasis were compared by integrated discrimination improvement (IDI) and net reclassification index (NRI). The flow chart is shown in Fig. 
Flow-chart. RS radiomic score