Discussion
malaria, vomiting, Abdominal pain, headache, anorexia
MALARIA, EVENTS, ANOREXIA
Progress towards the elimination of malaria in Madagascar depends on the involvement of the health system in rapid and effective case management. This requires not only the rapid diagnosis of suspected cases, but also the effectiveness of antimalarial drugs administered in each confirmed case. The main objective in this multisite, randomized, controlled, parallel-group trial in children with uncomplicated The treatment responses reported in this study demonstrate the good efficacy of ASAQ and AL. They are consistent with those of previous studies conducted in Madagascar [
Parasite clearance in the ASAQ arm at both study sites, antimalarial therapeutic efficacy, Madagascar 2018.
Parasite clearance in the AL arm at both study sites, antimalarial therapeutic efficacy, Madagascar 2018.Our results demonstrated that both assessed treatment regimens (ASAQ and AL) were well tolerated. The events observed during the assessment were expected and have already been described with this type of antimalarial. Abdominal pain, vomiting, headache and anorexia were the symptoms frequently reported by patients who took the artemisinin derivative in both groups. The tolerability of the treatment regimens was similar in our study. In contrast, in Cote d’Ivoire for example, it was shown that AL is more tolerable than ASAQ [At both sites, the uncorrected and corrected efficacy was lower in the AL group than in the ASAQ group. It is known that AL administration unaccompanied by fatty foods, as recommended by the manufacturer, may account for this difference that has been found in various studies, because both the effectiveness and tolerability of AL are better when the drug is taken with higher fat foods [