Statistical analysis
Statistical analysis was performed with R (version 4.1.2) in RStudio (version 2022.02.3 Build 492). Linear mixed-effects models (R package nlme version 3.1–157) were used to analyze the effect modification by GRS (exposure-by-GRS interaction) on lung function measurements, BAL immune cell proportion as well as BAL immune mediators. Participant ID were included in our model as random effects, and random intercepts were included in the models. A p-value of < 0.05 was considered statistically significant. Meth PC