INTRODUCTION
skin diseases, atopic dermatitis
INFILTRATION, ATOPIC DERMATITIS, DERMATOLOGIC CONDITION, DERMATOLOGIC DISEASES, SKIN DISEASES
Persimmon (A few dermatologic studies have explored the effect of PLE on inflammatory dermatologic diseases. PLE was reported to have an inhibitory effect on T cell activation via reduction of interleukin (IL)‐2 production in vitro; an additional in vivo animal model of atopic dermatitis resulted in reduced IgE levels, mast cell infiltration, and pro‐inflammatory cytokine expressions, especially Th2 cytokines, after oral administration of PLE, suggesting its role in inflammatory skin diseases such as atopic dermatitis.Although the anti‐inflammatory effect of PLE on inflammatory skin diseases such as atopic dermatitis seems obvious, the effect of PLE on other dermatologic conditions remains unknown. The effect of PLE in vitro was investigated, and it was found that PLE inhibited not only nitric oxide production but also inducible nitric oxide synthase (iNOS) and cyclooxygenase‐2 (COX‐2) expression levels in mouse macrophages. Moreover, it significantly reduced IL‐6 production as well as the expression level of 5α‐reductase in human follicle dermal papilla cells (HFDPCs).