Headache and Accompanying Symptoms
Headache, nausea, pain, phonophobia, throbbing, headache, photophobia
ADVERSE EVENTS
A blinded investigator (LK and CWN) obtained data on headache intensity and characteristics at baseline (T0) and every 10 min after the start of the infusion (T0) until T240 minutes using a standardized questionnaire. Headache intensity was recorded on a numerical rating scale (NRS) from 0–10 (0, no headache; 1, very mild headache [including a pressing or throbbing feeling]; 10, worst imaginable headache). Headache characteristics including localization, pain quality, aggravation by physical activity, and associated symptoms (nausea, photophobia, and phonophobia) were also recorded. After being discharged from the hospital, participants were asked to complete a headache diary every hour until 12 h following the infusion. Apart from headache intensity and characteristics, the diary recorded uptake of analgesics and possible adverse events (AE). Participants were allowed to take medication if the headache became intolerable. The standard rescue medication provided on site was 1000 mg paracetamol and 400 mg ibuprofen.