Added value of this study
inflammation, PWH
INFLAMMATION
In a randomized trial of aspirin intervention in 110 PWH, we comprehensively assessed the levels of pro-inflammatory and pro-resolving lipid mediators before and after aspirin intervention. Our results show that, in the interval tested, 12 weeks of aspirin administration did not increase levels of pro-resolving lipid mediators of inflammation in PWH. In addition, utilizing a well-characterized and well-matched cohort of HIV-seronegative individuals, our study also is the largest and most comprehensive study to characterize data on alterations of lipid mediators of inflammation by HIV status.