2.1. Data collection
CRC
The date of miRNA sequencing, mRNA sequencing (FPKM value), mutation expression, and corresponding clinical information of CRC were acquired from TCGA. The mRNA sequencing was transformed into log2(TPM+1). A total of 25 m6A modification regulators were selected from previous research including 8 writers (METTL3, METTL14, METTL16, WTAP, VIRMA, ZC3H13, RBM15, and RBM15B), 2 erasers (ALKBH5 and FTO), and 15 readers (YTHDC1, YTHDC2, YTHDF1, YTHDF2, YTHDF3, HNRNPC, FMR1, LRPPRC, HNRNPA2B1, IGFBP1, IGFBP2, IGFBP3, RBMX, LAVL1, and EIF3B).