Subject terms
T2D, weight loss
TYPE 2 DIABETES
Diet-induced weight loss is associated with improved beta-cell function in people with type 2 diabetes (T2D) with remaining secretory capacity. It is unknown if adding exercise to diet-induced weight loss improves beta-cell function and if exercise volume is important for improving beta-cell function in this context. Here, we carried out a four-armed randomized trial with a total of 82 persons (35% females, mean age (s.d.) of 58.2 years (9.8)) with newly diagnosed T2D (<7 years). Participants were randomly allocated to standard care (Results from a randomized clinical trial show that adding exercise to diet-induced weight loss can improve beta-cell function, measured as late-phase disposition index, in people with newly diagnosed type 2 diabetes.