Primary objective: Effects on reducing secondary spread of influenza virus
cough, ILI, sore throat, fever
SORE THROAT, VIRUS, VIRUS INFECTION, INFLUENZA
The primary endpoint was monthly number of influenza‐positive samples in the control versus intervention periods among ARI‐participant encounters. The predictor of interest was test‐and‐treat at the shelter/cluster‐month level (i.e., intervention vs. control periods). Shelters were analyzed with an intent‐to‐treat (ITT) analysis to preserve the advantages of randomization. Relative risk of influenza virus infection during the intervention period compared with the control period was calculated using a generalized linear mixed model (GLMM) following a Poisson distribution with a log link. The model was adjusted for calendar time with an offset of shelter maximum capacity and random effect for shelter and time. Due to low influenza virus circulation in Year 2, the primary outcome analysis for this study was calculated based on data collected only from Year 1. Influenza‐like illness (ILI) was defined as fever and cough, or fever and sore throat.