Ethics approval and consent to participate
In this randomized trial, written informed consent from participants should be obtained upon enrollment, and all processes of this trial will be executed in accordance with the Declaration of Helsinki and Good Clinical Practice Guidelines. The steering committees of the TBCC and ARO will supervise this study’s advancement. The Regional Research Ethics Committee C of the Institutional Review Board of the National Taiwan University Hospital approved this prospective randomized trial (No. 201902048MINC), which has been registered at ClinicalTrials.gov (NCT04046159).