Supplementary Information
anaphylaxis, breast cancer
ADVERSE REACTIONS, SENTINEL LYMPH NODE, ANAPHYLAXIS, BREAST CANCER
The online version contains supplementary material available at 10.1245/s10434-023-13824-6.Open Access funding enabled and organized by CAUL and its Member Institutions“Gold standard” lymphatic mapping for sentinel lymph node (SLN) biopsy involves the combination of blue dye (BD; patent blue, methylene blue, or isosulphan blue) and radioisotope (RI) labelled with technetium-99m.Methods for nodal identification have been variable in terms of type and number of tracers used since the advent of SLN biopsy as the principal procedure for axilla staging in breast cancer. Use of BD has been widespread since its introduction nearly three decades ago; some units even use BD alone. Some units, however, have abandoned BD from combination with RI due to potential anaphylaxis.Indocyanine green (ICG) fluorescence imaging utilises the green fluorophore dye, ICG, with a near-infrared camera to visualise subcutaneous lymphatic flow in real-time for axillary dissection of SLNs.For a new technology to be adopted into clinical practice, it should ideally be as effective as the current “gold standard” and at a reasonable cost. This study compared the clinical efficacy and costs between novel ICG-RI and “gold standard” BD-RI for SLN biopsy in early breast cancer in terms of number of SLNs identified, rate of failed mapping, identification of metastatic SLNs, and adverse reactions to dye tracer.