Introduction
cancers, tumor, pembrolizumab, melanoma, toxicity, cancer
CANCERS, TUMOR, MELANOMA, CANCER, ONCOLYSIS, METASTATIC MELANOMA
Oncolytic viruses represent a novel therapeutic modality for the treatment of cancer, and several have been or are currently being investigated as potential immunotherapies in patients with various types of cancers [In preclinical studies, V937 demonstrated rapid oncolysis of in vitro melanoma cell cultures and in vivo melanoma xenografts in immunodeficient mice [Pharmacodynamic effects of oncolytic viruses in the tumor microenvironment, including increased interferon production, CD8The anti–PD-1 monoclonal antibody pembrolizumab is a standard-of-care therapy for patients with advanced melanoma. In the phase 3 KEYNOTE-006 study, which included 834 patients with metastatic melanoma (65% were stage IVM1c), pembrolizumab demonstrated superiority over ipilimumab with respect to the dual primary endpoints of PFS and overall survival (OS), with less high-grade toxicity [