5. Conclusions
sepsis, decreased organ damage
SEPSIS, OXIDATIVE STRESS, SEPTIC SHOCK
Patients treated with antioxidants such as Vit C, Vit E, NAC, or MT, in addition to standard therapy, show reduced levels of proinflammatory cytokines and improved regulatory function in Il-2, IL-12, and IFN. There is improvement of the antioxidant capacity and reduction in biomarkers of oxidative stress with evidence of decreased organ damage measured by SOFA score. Combining antioxidants such as Vit C, MT, and NAC associated with standard therapy is a potential perspective in investigation through randomized clinical trials since it could improve other clinical conditions and pathophysiological mechanisms that converge in septic shock. Regarding the damage mechanisms involved, there is no evidence of improvement with the use of anticytokine biologicals and anti-apoptosis therapy, which evidences the need of research studies to follow for the comprehensive management of sepsis.