2.1. Patients and Study Design
critically ill
CRITICALLY ILL
A randomized, controlled clinical trial was conducted on critically ill patients with COVID-19. The design was a prospective, analytical, follow-up study of cases and controls. The sample of patients studied was made up of 140 consecutive patients over 18 years of age (women, 23.6%) admitted to the ICU with COVID-19. The groups’ distribution comprised a total of 72 patients treated with NAC (treated patients), and 68 patients not treated with NAC (control group patients). The sample size we used in our study is similar to the sample size of other studies similar to ours [