Conflict of interest
WL
Authors LH, TL, WL, ZW, BL, MX are employed by Akeso. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.The authors declare that this study received funding from Akeso Biopharma, Inc. The funder had the following involvement with the study design, datacollection, data analysis, data interpretation, and writing of the report.The reviewer QY declared a shared affiliation with the author JW to the handling editor at time of review.