Statistical analyses
REMISSION
In the original protocol, we calculated our power on an analysis of variance (ANOVA) with repeated measures. It yielded a sample size of All-analyses were conducted using SPSS.25 (IBM). Consistent with CONSORT guidelines, all-data from all randomized participants were analyzed according to the intention-to-treat approach [Responder (ISI change ≥ 8) and remission rates (ISI total score < 8) were calculated for the primary outcome (ISI) to determine clinical significance [