Interventions
multiple sclerosis, pain
MULTIPLE SCLEROSIS
The probiotic supplement, as well as the placebo, was provided by the TAKGEN ZIST, Tehran, Iran. During the study, patients were instructed to take one capsule daily after a meal. They received a total of 14 every two weeks. Some patients were given fewer than 14 capsules in specific follow-up periods to monitor their adherence to the supplement. Patients who did not complete their intervention were excluded from the analysis at the end of each two weeks based on the number of capsules remaining. All patients continued their routine treatments for multiple sclerosis during the study. Acetaminophen tablets were permitted for pain relief, up to 2 g daily. However, we advised patients to avoid taking other anti-inflammatory analgesics or NSAIDs.