Statistical analysis
The following observed data were used for the analysis of the plasma PK parameters with the noncompartmental PK approach using WinNonlin, version 8.2, software (Pharsight Co., Mountain View, CA, USA): the maximum observed plasma concentration (Cmax), the time to maximum observed serum concentration (Tmax), area under the concentration–time curve from the time of dosing to the last time point with the measurable plasma concentration (AUC0-t) prior to the next dose, AUC from the time of dosing extrapolated to infinity (AUC