Cox regression analysis for OS
BRAIN METASTASIS, LIVER METASTASES, BRAIN METASTASES, LUNG METASTASES, REGRESSION, LIVER METASTASIS, BONE METASTASES
In patients with stage II-IV CRNENs, univariate and multivariate Cox regression analyses were used to identify independent prognostic factors of OS. After univariate analysis, variables with a P<0.05 including sex, age, histology, grade, stage, surgery, chemotherapy, radiation, liver metastases, brain metastases, bone metastases, and lung metastases were further investigated in multivariate Cox analysis. After multivariate analysis, age≥75 (HR: 2.03, 95%CI: 1.5-2.76), grade III-IV (HR: 4.66, 95%CI: 2.92-7.42), stage ([stage III vs stage II] HR: 2.22, 95%CI: 1.25-3.94; [stage IV vs stage III] HR: 3.99, 95%CI: 2.03-7.83), liver metastasis (HR: 1.61, 95%CI: 1.03-2.51), brain metastasis (HR: 4.57, 95%CI: 1.66-12.58). In terms of treatment, surgery can significantly prolong the OS of patients with CRNENs (HR: 0.62, 95%CI: 0.44-0.86), but not chemotherapy or radiation (