The LOOP Study
stroke
STROKE, HEART FAILURE, DIABETES MELLITUS, MAY
The LOOP Study was a randomized, controlled, multicenter trial that investigated long-term continuous AF screening in individuals aged 70 to 90 years and with ≥1 additional stroke risk factor (arterial hypertension, diabetes mellitus, heart failure, or previous stroke). A total of 6004 participants were enrolled at 4 centers in Denmark (from January 31, 2014, to May 17, 2016) and randomized to either ILR screening or usual care (the control group) in a 1:3 ratio. During ILR monitoring, oral anticoagulation (OAC) was recommended when any new-onset ILR-detected AF episode ≥6 minutes was confirmed by ≥2 senior cardiologists. The trial design and the primary reporting of the LOOP Study have been published previously.The LOOP Study was approved by the Regional Scientific Ethics Committee for the Capital Region of Denmark (H-4-2013-025) and conducted in accordance with the Declaration of Helsinki. Oral and written informed consent was obtained from all study participants at inclusion.