Introduction
cancer, colorectal cancer, CRC, trauma
FUNCTIONAL DISTURBANCE, CANCER, COLORECTAL CANCER, IMMUNOSUPPRESSION
Worldwide, colorectal cancer (CRC) is the third most commonly diagnosed cancer, and the second for mortality [Immunosuppression is commonly observed in patients who underwent trauma and major surgery, which could be characterized by functional disturbances and quantity decline in lymphocytes [Therefore, we tested the hypothesis that deep anesthesia (BIS 35) could control surgical stress response effectively, hence CD4+/CD8 + ratio in the deep general anesthesia group is higher than that in the light general anesthesia group (BIS 55). In addition, it was previously reported that high CD4+/CD8 + ratio correlated with stronger cellular immunity [