Limitations of the study
Our study was limited by the relatively small sample size. We could not replicate our findings in an independent cohort of participants, simply because no similar study has ever been performed in humans. Furthermore, while meaningful and significant transcriptomic changes were observed, they have not yet been validated at the proteomic level. It is crucial to recognize that discrepancies between the different omics levels of molecular organization are common and should be expected. In addition, our analysis excluded 17.5% of protein‐coding genes (as mentioned in the Results section) because of their low count in many samples. Pathway analysis with these genes (using g:Profiler) identified some important pathways, such as steroid biosynthesis, which is missing in this report (Table 