Statistical Analysis
cancer type, CINV, morning sickness, head and neck,
MOTION SICKNESS
We analyzed CR, CC, TC, and TTF in the acute, delayed, and overall phases for all of the following 6 items of CINV risk factors: sex, age, and cisplatin dose (which were defined as allocation adjustment factors) and history of motion sickness, drinking habit, and history of morning sickness during pregnancy (as collected from the symptom diary). For CR, CC, and TC, the point estimates and 95% CIs of the differences between groups were calculated, and a Mantel-Haenszel test was performed. The Kaplan-Meier method was used to calculate median estimates and 95% CIs of TTF in each group, and a log-rank test was used for intergroup comparisons. A forest plot of delayed CR in subgroups was used to analyze the risk difference (RD) for the 6 risk factors, ECOG PS score (0 vs 1 to 2), and each cancer type (head and neck, esophageal, lung, gastric, and gynecological).Two-sided 