Adherence to the Seattle protocol

To evaluate adherence to the Seattle protocol, the number of quadrantic biopsies taken per 2 cm of BE was assessed. The mean number of biopsies in the different strata 2–5 cm, 6–10 cm, and ≥ 11 cm was 4.3 (range 1.3–8.0), 3.8 (range 0.8–5.3), and 4.0 (range 3.4–4.3), respectively. Even though adherence to the Seattle protocol was high across different strata and did not drop below the recommended standard, we found variation within the strata and a small but statistically significant decrease in the mean number of biopsies per 2 cm of BE with increasing length (
