Discussion
melanoma, human melanoma, CM, psoriasis
MELANOMA, PSORIASIS
To our knowledge, this study was the first attempt to explore the causal relationship between psoriasis and CM using the summary statistics of FinnGen Alliance R9 and the large GWAS meta-analysis conducted by Matthew et al. (Most current studies on the effect of psoriasis on CM are observational cross-sectional studies or retrospective cohort studies, with inconsistent findings. For instance, Egeberg et al.’s (NF-κB has pleiotropic properties in the surrounding environment, but three are its basic roles. First, it is involved in pro-inflammatory responses. In human melanoma, many NF-κB-regulated chemokines are expressed at high levels: CXCL8 or IL8, CXCL1 (melanoma growth-stimulating activity), CCL5 (regulatory activation, normal T expression and secretion), and CCL2 (In addition, studies on psoriasis risk in patients with CM are few and inconsistent. The retrospective cohort study of Sam et al. (