5. Conclusions
intestinal barrier dysfunction
METABOLIC DISEASES, INTESTINAL BARRIER DYSFUNCTION, TYPE 2 DIABETES
In summary, our data suggest that the intake of a sucralose-sweetened beverage in a physiological amount, e.g., 1 L, has no effect on intestinal barrier function in healthy young adults. To our knowledge, this is the first study which examines the effect of an acute intake of sucralose on endotoxin levels in healthy, normal-weight human subjects. However, whether an intake of sucralose over an extended period of time and at higher doses or in individuals suffering from health impairments has similar limited effects on intestinal barrier function needs to be determined in future studies. The results of our study also add further weight to the hypothesis that dietary sugars like sucrose may be critical in the development of intestinal barrier dysfunction suggested to contribute to the development of various metabolic diseases like MASLD and type 2 diabetes [