PRIMARY TAKE AWAY LESSONS OF THIS CASE REPORT
gait disturbance, forceful
ONCOLOGY, DISEASE PROGRESSION
Close monitoring performed by qualified exercise trainers during supervised exercise sessions can lead to the detection of subtle but significant signs of disease progression that may not be recognized yet by clinicians, patients or their family. Early detection of disease progression can make a significant difference to the patient’s QoL and life expectancy.We recommend that changes in movement patterns that become uncoordinated or less forceful, gait disturbance, a deterioration in balance, slower or clumsier eye movements, changes in mental state or behavior (more angry, uninhibited, disconnected, sleepy, etc.), or any unexpected performance decline recognized by a trainer should be brought to the patient’s attention.The results of the study are presented clearly, honestly, and without fabrication, falsification, or inappropriate data manipulation. The results of the present study do not constitute endorsement by the American College of Sports Medicine.We would like to thank oncologists Cristina Churruca, Isabel Álvarez and Nerea Ancizar (UGC Medical Oncology from Gipuzkoa, OSI-Donostialdea-Onkologikoa) and radiotherapist María Pagola (Fundación Onkologikoa) for their support in discussions about the importance of publishing this case report.Statements and declarations: The EFFECT study is part of the PREFERABLE project and has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No 825677. The study is also funded by the National Health and Medical Research Council of Australia (2018/GNT1170698). These funding bodies do not have any role during the execution, analyses, interpretation of the data, or decision to submit the results of this study.Competing Interests: K. S. has received speaker honorarium from Adviva, Germany. The rest of authors declare that they have no competing interests.Authors Contribution: All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by M. P., A. M. M., and M. B. The first draft of the article was written by M. P., M. M. S., and A. M. M. All authors commented on previous versions of the article. All authors read and approved the final article.Ethics Approval: The EFFECT study was performed in line with the principles of the Declaration of Helsinki. The study protocol was approved in October 2019 by the institutional review board of the University Medical Center Utrecht, the Netherlands, and by the local ethical review boards of all participating institutions. In this case by CEIm-Euskadi under the reference PI2019202. The study was registered with 