Subgroup differences of the associations between AGEs and IMT
Diabetes, CKD, diabetes
CVD, TYPE 1 DIABETES, DIABETES, CHRONIC INFLAMMATION, DIABETES
The association of SAF with IMT showed subgroup differences. It was stronger in people who had diabetes or CKD and was insignificant in those without and was seen in men but not women, arguing for a more pronounced impact of AGEs on IMT in diabetes or CKD, and in men.Diabetes and CKD are two major risk factors for AGE accumulation and CVD. Our observation may indicate that AGE accumulation is involved in arterial wall thickening and further contributes to an elevated CVD risk in diabetes or CKD. In line with our finding, a study in people with type 1 diabetes showed that, compared to regular glucose management, 6.5 years of intensive glucose management resulted in a lower IMT [Sex differences in the association between SAF and IMT suggest that SAF is more relevant for IMT in men. This difference may be attributed to the better risk profile of women. Moreover, women generally have a lower IMT than men before menopause potentially due to a lower grade of chronic inflammation [