Subjects
alcohol abuse, drug dependence
This study was conducted at the Phase I clinical research center of Shanghai Xuhui Central Hospital. All subjects had been informed and provided signed written informed consent before participating in the study. Subjects of the fasting study were recruited in July 2018, and subjects of the fed study were recruited in October 2018. The investigators in the clinical center were required to comply with the rules that protect the subject’s privacy. Except for them, nobody had access to information that could identify individual participants during or after data collection.The inclusion criteria comprised healthy Chinese volunteers aged 18 to 40 years, with a body mass index between 19.0 to 26.0 kg/mThe exclusion criteria included a history of heavy smoking (more than 10 cigarettes per day) or suspicion of drug dependence and/or alcohol abuse. Those who had participated in other clinical trials or donated or lost blood of more than 400 mL within 3 months were excluded. Subjects were instructed from taking any medications for at least 14 days before study drug administration.