Relationship with previous studies
sepsis, septic shock
SEPSIS, SEPTIC SHOCK
Our findings appear to differ from those of recent randomized controlled trials, which assessed the effect of very high dose vitamin C in patients with sepsis [A possible explanation for our findings might relate to the amount of the study drug administered. In our study, for example, the median serum vitamin C (measured as ascorbate) concentration was approximated 6000 µmol/L. This is more than 30 times higher than in the CITRIS-ALI trial [Another possible explanation may relate to the preparation used. In our trial, we used NaAscorbate, which has a physiological pH. In contrast, in the LOVIT trial, investigators administered ascorbic acid [Finally, single mega-dose vitamin C therapy has already been given to patients in conditions other than septic shock with doses > 200 g/day [