5. Conclusions
cancer
CANCER
This phase II exploratory study substantiated the safety and efficacy profile of regorafenib when used as a second-line treatment. Molecular investigation of patients metastatic biospecimens pinpointed several potential biomarkers linked to unfavorable prognoses in patients with mCRC using various approaches, including pathways analysis, mutation assessment, and copy number analysis. It is worth noting that many of these identified candidates have already shown associations with poor outcomes in other cancer types or among patients undergoing different treatments. This suggests they might not serve as exclusive predictive biomarkers solely for regorafenib. An intriguing avenue for further exploration lies in delving deeper into these biomarkers’ potential relevance within the context of drug classes like tyrosine kinase inhibitors (TKIs). Since similar drug classes can involve overlapping mechanisms leading to treatment resistance, investigating these biomarkers in TKIs could yield insights into redundant factors contributing to inadequate treatment responses.