Statistical analysis
SD
DISEASE
The statistical computations of the intention-to-treat (ITT) population were performed by SPSS version 26.0. Descriptive statistics (mean, median and range) were calculated for all variables. The Kaplan–Meier method was used for estimation of survival measures (median OS and PFS) along with 95% confidence interval (CI). Differences between survival measures among subgroups were estimated using the univariate Cox model and significant factors would be included in a multivariate Cox model, with P values of < 0.05 considered statistically significant. 3-month PFR, response rates by i.e. Complete Response (CR), Partial Response (PR), Stable Disease (SD), Overall Response Rates (ORR) were calculated with 95% CI based on exact binomial distribution.