1. Introduction
obesity, Obesity
OBESITY, OBESITY
A great number of chemically diverse pancreatic lipase (PL) inhibitors have been identified to tackle obesity; however, very few of them have entered clinical studies. The ethanolic extract of sesame meal is a potent PL inhibitor, and its activity hinges exclusively on two free fatty acids: linoleic acid and oleic acid, which were proven to reduce postprandial triglyceride excursion in rats. Herein, to investigate the clinical efficacy of the sesame meal extract, in a crossover trial, 30 healthy volunteers were randomized to receive the sesame meal extract containing experimental food or placebo along with a high-fat meal. Treatment with the sesame meal extract significantly lowered the incremental postprandial serum triglyceride concentration and reduced the incremental area under the curve (iAUC) by 16.8% (The past decades have seen an ever-worsening public health crisis worldwide—the obesity epidemic. Obesity increases the risk of a range of chronic conditions that often lead to severely impaired quality of life and premature mortality. Epidemiological studies have revealed a direct relationship between the incidence of overweight/obesity and dietary fat intake, which, in most populations, has exceeded the recommended <30% of total energy intake [Sesame (