Preservation of type-1 error rate
The overall effectiveness of the intervention will be assessed using a multiple degree-of-freedom test with a null hypothesis of no difference between study arms at 90 days post-randomization. Based on our prior studies of pediatric medication regimen complexity, we will adjust for potential confounders including patient age, number of complex chronic conditions, and recent acute healthcare utilization. All quantitative analyses will be performed in Stata 17.0 (College Station, TX). We will use a 2-sided significance level of 0.05 for all hypothesis testing; thus, the type-I error rate for the assessment of overall effectiveness is fixed at 5%. Standard errors and 95% confidence intervals will also be reported.