Study population
PRS, COPD
CHRONIC OBSTRUCTIVE PULMONARY DISEASE, COPD, ADVERSE DRUG REACTIONS
After screening for eligibility between 1 December 2017 and 31 December 2019 in the Shanghai Pulmonary Hospital, 113 patients were randomly assigned to a treatment group. A total of 20 patients who had undergone randomization were excluded from the modified intention-to-treat population, which comprised 93 patients (46 in the short-course PRS regimen group and 47 in the standard regimen group) (Flow chart for enrolment, randomization and follow-up of patients. One patient on the Parabolic Response Surface (PRS) regimen permanently changed assigned regimen due to shortage of clofazimine, while the rest were due to adverse drug reactions. NTM: Baseline characteristics of patients in the modified intention-to-treat population.Note: All data were presented as number (percentage) unless specified. COPD: chronic obstructive pulmonary disease.Median (interquartile range).Smear grade is referred to the Chinese national guidelines released in 2021 [