Trial design and setting
malaria, YHD
MALARIA
A two-groups, open-label randomized control trial to compare the use of azithromycin versus nothing in pregnant women receiving monthly sulfadoxine-pyrimethamine for the intermittent preventive treatment of malaria in pregnancy (IPTp-SP), with a 1:1 allocation ratio was conducted. Pregnant women included in the intervention group received monthly sulfadoxine-pyrimethamine (1500/75 mg) and two grams of azithromycin (1 g daily for 2 days) given at the second and third trimesters of pregnancy (SPAZ). Those included in the control group received monthly sulfadoxine-pyrimethamine (1500/75 mg) (IPTp-SP). Azithromycin was administered during the first antenatal visit of the second and third trimesters of pregnancy simultaneously with SP under supervision of study investigators.The study was carried out in three peripheral health centres of the Yako health district (YHD), in northern Burkina Faso. This region covers a population of 424,577 inhabitants, and where 23,000 pregnancies were exposed to malaria in 2017 [