High baseline and 24W weight and BMI associate with serum MPA and NET concentrations
overweight
OBESE
Most of the women were either overweight (DMPA-IM 23.5% and NET-EN 22.9%) or obese (DMPA-IM 47.5% and NET-EN 39.0%) at D0. A significant difference between the DMPA-IM and NET-EN arms was detected at D0 for weight (kg) and BMI in the mITT analysis (To investigate possible associations between progestin concentrations and baseline weight and BMI, we excluded all participants with non-study progestin concentrations greater than 1.5 nM at 25W or at D0, as well as all those that missed their study progestin injection at 24W (as indicated in Methods) (PP2 analysis). For this PP2 subgroup, we did not detect significant differences between the DMPA-IM and NET-EN arms at baseline for weight (p = 0.22) or BMI (p = 0.12). We detected significant negative correlations between the 25W MPA concentrations and D0 weight and BMI in the DMPA-IM arm (