Discussion
’ depression, ’s mood, painless, pain, type 2 diabetes often neglect the control of, type 2 diabetes mellitus, NRS, diabetes
HYPOGLYCEMIA, TYPE 2 DIABETES MELLITUS, DIABETES
Needle-free injectors use the principle of high-pressure jets, and mainly adopt transdermal dispersion drug delivery technology. Without the aid of needles, the liquid drug is ejected out from a small aperture at high speed (flow rate is generally greater than 100m/s) to reach the subcutaneous tissue with insulin distribution averagely higher than when a needle injection is used. This provides a very conducive area for maximal and complete absorption of insulin under the skin into bloodstream (As a group that cannot be ignored, patients with early-onset type 2 diabetes often neglect the control of diabetes because they are busy with work and have the impression that they are in good health, thus causing an aggravation in the decrease of their β-cell function (Time in range (TIR) refers to the time or percentage of glucose in the target range within 24 hours. It is a new indicator of blood glucose control that has attracted much attention in the field of diabetes. TIR can more intuitively and visually reflect the blood glucose fluctuation status of patients throughout the day (The WHO-5 scale was scored before the intervention, before the switch and at the end of the study. It must be noted that all the questions were willingly answered and filled in by the patients. The Numeric Rating Scale (NRS) is the most widely used unidimensional assessment scale (A significant difference was observed in a meta-analysis (The transdermal diffuse flow technology of needle-free injectors can increase the bioavailability of insulin (Needle-free injection is not painless and non-invasive, but minimally painful and minimally invasive. When the medical composition in the insulin injection penetrates the human epidermis, a small injection mark will be left, but since only the medicinal liquid enters the skin, and the injection depth is approximately 4-6mm with few nerve endings in this range, no obvious irritation will occur (Needle-free injection does not use needles, which not only reduces the patient’s physical pain, but also eliminates the patient’s psychological fear of injection needles. The WHO-5 scale can reflect an individual’s mood or sense of well-being. In this study, the WHO-5 score of the needle-free injection group was higher than that of needle-based injection, and the difference was statistically significant (p<0.05). Patients were more willing to accept needle-free injection, so the well-being index was significantly improved. Studies have shown that the application of needle-free syringes can improve patients’ depression as well as their quality of life (In conclusion, compared with traditional insulin pens, the use of needle-free syringes and enhanced management can effectively reduce the fasting blood glucose of patients with early-onset type 2 diabetes mellitus treated with premixed insulin. To improve adherence to insulin therapy, critical attention should be paid to adjusting the insulin dose in time to aid in reducing the occurrence of hypoglycemia. Needle-free injection is more suitable for young patients and people who are Trypanophobia and it is particularly important to strengthen injection guidance among patients with early-onset type 2 diabetes mellitus.