INTRODUCTION
obesity, chronic disease
OBESITY, SECONDARY, CHRONIC DISEASE
The population of older adults is growing at an unprecedented rate and is paralleled by an increasing prevalence of chronic disease (Kennedy et al., The comprehensive assessment of long‐term effects of reducing intake of energy (CALERIE) study, funded by the National Institutes of Health (NIH), was the first clinical trial to demonstrate the feasibility of achieving sustained, moderate CR in healthy adults without obesity (Rochon et al., The current study uses the Geometric Framework for Nutrition (GFN) analytical approach to evaluate the effect of dietary macronutrient composition on adherence to CR and resultant modification to cardiometabolic risk factors in a secondary analysis of the CALERIE trial. Our primary objective was to evaluate whether self‐selected diet composition changes during CR and whether these changes predict short‐term (12 months) or long‐term (24 months) adherence to CR. Our secondary objective was to explore the relationships between macronutrient composition, standard dietary pattern scores, and cardiometabolic risk factors.