Proteomics-based protein identification and quantification
To analyze the protein expression in the 16 patients before and after three months of exercise, DIA was performed by analyzing the samples in a randomized order. Finally, 433 proteins (200 upregulated and 233 downregulated, Fig. 
The protein–protein interaction network analysis was performed using Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) software. The nodes reflect individual proteins enriched in the analysis, and the edges are the functional associations based on various online resources. (The plasma proteome profiles before and after exercise were compared, to determine significant differences in plasma protein expression, reflecting a significant effect of exercise in these patients. Paired t-test was performed to identify significantly DEPs between two intervals of three months of exercise. We found 60 significantly expressed proteins with a 