Reproductive outcomes
insufficiency
EARLY PREGNANCY, PREGNANCY LOSS
After the treatment, all patients entered ET cycles. The outcomes for Groups 1–3 are summarized in Table Reproductive outcomes for Groups 1–3.The data are presented as raw counts and % incidence, subject to exact Fisher test.One patient in Group 2 and one patient in Group 3 experienced spontaneous pregnancy loss at 18–19 weeks due to isthmic-cervical insufficiency. In Group 4 (n = 5) three patients successfully entered pregnancies concluded with full-term healthy deliveries.The rates of clinical pregnancies and live births in all groups were statistically similar. At the same time, the odds of clinical pregnancy for Groups 2 and 3 were, respectively, 2 and 1.8 times higher compared with Group 1, the 95% confidence intervals (CI) for the odds ratio (OR) being [0.6, 7.3] and [0.5, 6.9], respectively. In addition, the rate of live births for Groups 2 and 3 was higher compared with Group 1, while the odds of live birth for Groups 2 and 3 were, respectively, 1.8 and 2 times higher compared with Group 1, the 95% CI for OR being [0.4, 8.7] and [0.5, 10.0]. The odds of early pregnancy loss for patients receiving conservative therapy (Group 1) were 2.4 times higher (95% CI for OR [0.1, 44.1]) compared with patients receiving injections of autologous PRP as a part of complex therapy in ART programs.