Acknowledgments
This trial was funded by the Brazilian National Council for Scientific and Technological Development (CNPq, 423924/2016-8) and the São Paulo Research Foundation (FAPESP, 2015/14231-0). We would like to thank the Brazilian National Council for Scientific and Technological Development (CNPq, 423924/2016-8) and the São Paulo Research Foundation (FAPESP, 2015/14231-0) for supporting this trial.