Safety evaluation
high-density lipoprotein-cholesterol, occult blood reaction
ADVERSE EVENTS, BLOOD
As a safety evaluation, it was performed that, physical measurement (height, weight, and body mass index), physical examination (systolic blood pressure, diastolic blood pressure, and pulse), hematological tests (leukocyte count, erythrocyte count, hematocrit, and platelet count), blood biochemistry tests (total protein, albumin, total bilirubin, indirect bilirubin, alkaline phosphatase, aspartate transaminase, alanine transaminase, L-lactate dehydrogenase, gamma-glutamyl transpeptidase, total cholesterol, triglycerol, high-density lipoprotein-cholesterol, urea-nitrogen, creatinine, sodium, potassium, chloride, blood glucose, and hemoglobin A1C), urinalysis (protein, glucose, and occult blood reaction), and medical interviews. Blood and urine analyses were conducted at BML, Inc. (Saitama, Japan). Blood collection was performed after fasting for 4 h or more. The participants completed daily life diaries to investigate the status of consumption of the supplements and the presence of adverse events.