CONCLUSIONS
HIV-associated cryptococcal meningitis
STERILITY
There are no recent controlled trials of HIV-associated cryptococcal meningitis from high-income countries. Thirteen trials have been published between 1990 and 2010; those trials recruited 1623 patients in high-income settings from 1987 to 2007 [In conclusion, there are limited comparable data from high-income countries to clearly compare the clinical, microbiological, and safety outcomes observed in the AMBITION trial with those observed in high-income settings where patients are managed with 2 weeks of liposomal amphotericin plus flucytosine. The EFA, high rates of CSF sterility at 2 weeks, and absence of relapse cases observed in the AMBITION trial indicate that the AMBITION antifungal combination is extremely effective at clearing 