Evaluating Cross-sectional Associations of “Bridge” Symptoms with Depressive and Manic Symptom Clusters in the Acute Treatment Phase
manic, sleep disturbance symptoms, depressive, SE, irritability
A total of 166 (48.4%) youth in this study sample reported having both “difficulty with sleep” (CDRS-R item 4 > 2) and “decreased need for sleep” (YMRS item 4 > 0) at study baseline (The overlap in sleep disturbance symptoms (CDRS-R item 4 > 2 and YMRS item 4 > 0) was associated with the co-occurrence of depressive and manic symptom clusters. Fig. (A total of 318 (92.7%) youth in this study sample had irritability (CDRS-R item 8 > 2). The overlap in irritability symptoms (CDRS-R item-8 > 2 and YMRS item 5 > 0) was associated with the co-occurrence of depressive and manic symptom clusters. The subgroup with overlap irritability symptoms (n = 277) at study baseline had higher symptom severity in both depressive (mean CDRS-R total = 58.85, SE = 0.50) and manic symptom clusters (mean YMRS total = 6.14, SE = 0.19), while the absence of manic symptom of “irritability” (YMRS item 5 = 0) occurred in only 41 youth and had significantly lower YMRS total (mean 1.02, SE 0.36; 95% CI for presence 