Discussion
PMS
DISEASE, RECRUITMENT, PMS
This study evaluated discomfort following the colonoscopy procedure and the long-term disease relapse rate for approximately 8 weeks after colonoscopy in a single-blinded RCT. Subjective symptoms after colonoscopy were significantly different between the COPrevious studies reported that colonoscopy performed with COThe reason for the different relapse rates between groups at week 8 but not at week 1 is unclear; nevertheless, changes in the intestinal microbiota of the patients may provide a partial explanation. A recent RCT that examined changes in gut microbiota in fecal samples collected after colonoscopy with COIn this study, one patient had an MES = 3 with PMS = 0 at the beginning of the study. The PMS is known to well correlate with the full Mayo score, including the MES, and is widely used because it is noninvasive [Furthermore, although blood pressure changes did not differ between the two groups, changes in the SpOThis study has some limitations. First, this was a single-center study and not double-blinded. In addition, the number of participants was relatively small because of the increase in the number of cases undergoing sedated endoscopic procedures, making it difficult to recruit the required number of patients despite nearly doubling the recruitment period. If there had been a larger number of participants, there might have been a significant difference in the primary endpoint. Second, the exact amount of air or CO