Participants
Sepsis, glucose-6-phosphate deficiency, infection, septic shock, sepsis
SEPSIS, HEMOCHROMATOSIS, INFECTION, KIDNEY STONE, SEPTIC SHOCK, SEPSIS
Twenty-three adult patients with sepsis and septic shock were enrolled in the study within 24 h following admission to the Central Department of Intensive Care in Lithuanian University of Health Sciences Hospital Kaunas Clinics during a period between 2019 January to 2021 January (Fig. Following the third international consensus definition, septic shock was defined as sepsis requiring vasopressor therapy to elevate MAP > 65mmHg and lactate concentration greater than 2 mmol/L despite adequate fluid resuscitation. Sepsis was diagnosed in the presence of suspected or documented infection and an acute increase of ≥ 2 points in the Sequential Organ Failure Assessment (SOFA) score [Patients were excluded if consent was impossible to obtain; if they were younger than 18 years old; if pregnant or breastfeeding; if moribund and not expected to survive 24 h; if there was a known history of kidney stone, glucose-6-phosphate deficiency, hemochromatosis, or solid organ transplantation; as well as and if the sublingual mucosa was damaged.
Flow diagram of the study