2.4. Exclusion criteria
hypohidrosis, allergy, drug-induced anhidrosis, pain, Fabry disease
HYPOHIDROSIS, ALLERGY, ATOPIC DERMATITIS, AUTONOMIC NERVOUS SYSTEM DISORDER, FABRY DISEASE, HYPOTHYROIDISM, DISEASES
Patients with other causes for dermal pain.Patients with atopic dermatitis, Sjögren syndrome, hypothyroidism, Fabry disease, autonomic nervous system disorders, or drug-induced anhidrosis. To exclude these diseases, SS-A antibodies, SS-B antibodies, FT3, FT4, and TSH will be measured, and subjects with abnormal values will be excluded. In addition, α-galactosidase activity will be measured in patients who experience pain in their hands and feet, not related to temperature elevation, and hypohidrosis that appeared before school age. Genetic testing of α-galactosidase may need to be performed in women. Patients with these abnormalities would be excluded from the study.Patients with a history of allergy to icatibant.Patients who are pregnant or breastfeeding.