Endpoints
death
EVENT
The primary endpoint was defined as the time from randomization to a two-point improvement on the 7POS or live hospital discharge, whichever occurred first. Patients who withdrew their informed consent without a previous two-point improvement or live hospital discharge were censored at the respective date. Patients who were lost to follow-up were censored at the date of last contact. Administrative censoring was conducted at day 84 for all patients who were still alive but did not experience an improvement or discharge until day 84. The event ‘death from any cause’ was handled by censoring deceased patients without previous two-point improvement or live discharge at day 84 (in analogy to the approach of ref. 