Psilocybin specifically increases FC in a subnetwork with the hub-regions DRN and hypothalamus
In addition to the hypoconnectivity within the delineated wide-spread cortical network, our ROI-based NBS approach revealed a well-localized psilocybin-induced increase of FC in circuits focusing on subcortical brain structures. Specifically, DRN and hypothalamus acted as hub regions of these hyperconnected circuits, with increased FC to various cortical areas including prefrontal, sensory-processing and retrosplenial regions. With psilocybin’s mode of action as an agonist on 5-HT receptors (reviewed by Ling et al. [