Research design
osteoarthritis, OA
OSTEOARTHRITIS
We conducted a two-sample Mendelian randomized method. Initially, we assessed the causal relationship between systolic blood pressure(SBP) and diastolic blood pressure(DBP) and all OA, hand OA, hip OA, and knee OA. Next, we employed the multivariate Mendelian randomized(MVMR) study method to examine the impact of blood pressure on these four types of OA after multivariate adjustment. Finally, we utilized published genetic variation of antihypertensive drug targets as instrumental variables to evaluate the effects of 12 types of antihypertensive drugs on OA. These drugs included alpha-adrenoceptor blockers, angiotensin-converting enzyme inhibitors, angiotensin-II receptor blockers, beta-adrenoceptor blockers, calcium channel blockers (CCB), centrally acting antihypertensive drugs, loop diuretics, potassium-sparing diuretics and aldosterone antagonists, renin inhibitors, thiazides and related diuretics, and vasodilator antihypertensives. We also used the independent cohort of osteoarthritis in the UK Biobank to conduct a validation analysis.