Randomization
NRN
We will randomly assign infants to intervention arms of either rapid weaning (15% decrements from the stabilization dose) or slow weaning (10% decrements from the stabilization dose). The Neonatal Research Network Data Coordinating Center (NRN DCC) will centrally randomize participants. They will develop an allocation sequence with randomly varying block sizes, and they will implement this sequence through a central process that will be available 24 h each day. The NRN DCC will independently randomize multiple births. Pharmacy personnel of each participating hospital will be the only staff with access to group assignment.