Author Contributions
A.P. and G.Q.S. designed the current analysis. A.P. and A.T.C. conducted biomarker experiments. A.P. analyzed the data, and S.L.A. provided advise on the analysis and interpretation. A.P. wrote the first draft of the manuscript with revisions from M.L.O., D.D.S., S.V.-L., S.L.A., A.T.C. and G.Q.S. All authors have read and agreed to the published version of the manuscript.