Discussion
death, postoperative cognitive dysfunction, postoperative pain, POCD, cognitive dysfunction
COMPLICATIONS, INFLAMMATORY RESPONSE
In this randomized controlled study, the incidence of cognitive dysfunction 3 and 7 days after surgery in the lidocaine group was lower than that in the control group (In addition to effective postoperative analgesia and anti-infection treatments, attention should also be paid to postoperative cognitive changes in patients to achieve early and rapid postoperative recovery. Studies have shown that the incidence of POCD increases significantly in patients undergoing gastrointestinal surgery, which prolongs the length of hospital stay, increases the incidence of complications, and even leads to death [The effect of intravenous lidocaine on postoperative rehabilitation of patients undergoing laparoscopic colorectal surgery is a very important aspect. Previous studies have found that patients receiving intravenous lidocaine during the perioperative period had earlier intestinal peristalsis recovery, ambulation and better analgesic effect [In terms of the dosage of lidocaine, previous studies on the effects of different doses of lidocaine on patients during the perioperative period have found that relatively small doses (2 mg/kg/h) of lidocaine during the perioperative period can also effectively reduce the inflammatory response of patients [Of course, there are still some shortcomings in this study. First, we did not worked on a population selected for a high risk of postoperative cognitive dysfunction, such as frailty, or cardiac surgery. In addition, the results of this study were basically observational indicators, without serological indicators such as inflammatory factors to further support the conclusion. Finally, we did not focus on postoperative pain and analgesia, which likely to interact with cognition.