2.6.2. [Day 2].
The same procedure as on Day 1 will be followed to administer the drug and conduct the (3rd and 4th) thermal load before and after drug administration. The placebo (saline) will be subcutaneously injected into patients who receive icatibant on Day 1, while icatibant to those who receive placebo on Day 1. A washout period of ≥ 9 h will be allowed between drug administration on Day 1 and 2. The period was established as 5 times the half-life (T1/2 1.7 hours) of icatibant