1. Introduction
coronavirus disease 2019
CORONAVIRUS, CORONAVIRUS DISEASE 2019, SEVERE ACUTE RESPIRATORY SYNDROME, ACUTE INFECTION
The emergence and spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to the global pandemic of coronavirus disease 2019 (COVID-19) (It has been demonstrated that nasal irrigation and oral rinse with physiological saline solution is a simple and effective way to reduce acute infection of the nasal and oral pharyngeal mucosa (Recent studies have shown that coronaviruses are unstable under alkaline conditions. Coronaviruses are rapidly and irreversibly inactivated by brief treatment at pH 8.0 and 37°C with a half-life of ~30 min (