Randomization
Assignment of the POINCARE-2 strategy was at the cluster level and performed by JMV. PEB recruited volunteer ICUs. JMV used computer-generated numbers to randomly assign each ICU to one of the 12 sequences. ICU staff were informed about their own allocation 1 month before their time of inclusion. ICUs were blinded to other ICUs allocation (until allocation occurrence). Once an ICU was assigned to a sequence, the research team met with the whole ICU staff and the dedicated onsite research nurse to inform them about the trial procedures for the control period during the month before the time of inclusion. The control period started at this time at a cluster level. The control period was followed by a training period (Additional file Investigators continuously recruited participants over 6 periods (i.e., 3 cluster-periods contributing to the control group, then 3 cluster-periods contributing to the strategy group). All participants recruited over one cluster-period were included in either the control or the strategy group, depending on date of admission to the recruiting ICU (Fig. 