Author contributions
PATHOLOGY
A.K., T.B., and A.S. designed the trial. M.P., M.S., B.K., H.L., U.T.H., G.H., L.W., M.B., T.E., P.S., T.B., and A.K. recruited patients, contributed to patient care and collected the clinical data. M.P., T.H., and A.K. analyzed and interpreted the clinical data. B.N.K. designed the ctDNA analysis and performed the ctDNA sample experiments. T.W. performed the bioinformatic analyses of ctDNA, WES sequencing and methylation data. B.N.K. interpreted the ctDNA and WES sequencing data. A.S., D.K., M.B., and M.K. provided sequencing of tissue samples and central pathology review. K.K. provided the gene expression profiling analysis. S.D. provided central radiology review. T.H. created the statistical plan and made the sample size calculation. B.N.K. and T.H. conducted the statistical analysis. M.P., B.N.K., and A.K. wrote the first draft of the manuscript. All authors participated in developing or revising the manuscript, reviewed, and approved the final draft of the manuscript for publication.