Strengths and limitations
Study PRGF was a randomized controlled trial with a modest sample size, although larger than most studies in its field [Beyond the specific characteristics of the trial, evidence of several protocol violations has been proved over the RIAT process, clearly undermining the results showed by the original journal publication. On the other side, the RIAT development has been feasible due to the access to two major sources of data (protocol and final report) but it must be recognized that our re-analysis was also limited mainly related to the lack of individual participant data. This information was formally requested with no response received from the authors, which has prevented us from presenting results in more detail but also from discarding other potential problems such as data fabrication. Nonetheless, having in mind these limitations, we remain fully confident on the support that the existent data confer to our results.