Efficacy
bone pain, pruritus, sweats
At the time of data lock, 28 patients had received RUX for at least 6 months. Median time on drug during this first 6 months of treatment was 173 days (range 151–189). Efficacy variables at 6 months were assessed and compared to the screening/baseline variables, as pre-specified in the protocol for the futility analysis.After 6 months, the median hematocrit level decreased from 46% (no missing values; range 34.6–61%) (IQR 42.98–47.08%) to 41.45% (no missing values; range 32–52%) (IQR 37.25–44.95%) (Hematocrit levels and frequency of phlebotomies over time. (Left) Hematocrit (Hct) was assessed at screening and at 6 months of RUX treatment (EOM6) and decreased from 46% (no missing values; range 34.6–61%) (IQR 42.98–47.08%) to 41.45% (no missing values; range 32–52%) (IQR 37.25–44.95%) (MPN-SAF symptom scores for pruritus, night sweats, and bone pain over time