Author contributions
D.W., P.A., Z.P., S.H. conceived and designed the manuscript. A.M., D.B., H.M., N.H., Z.P. conceived, designed and delivered the original trial. T.F., M.C. A.G., I.G., D.W. performed the analysis. D.W., Z.P., A.M., P.A. wrote the main manuscript. All authors reviewed the manuscript.