2.5. Sample size calculation
RLS
As this is an exploratory study to generate the first results and further queries about the effect of hydrotherapy and acupressure in patients with RLS, we did not make a sample size estimation. As we expect about 10% of the patients to drop out of the study before week 12; 17 randomized patients per group (51 randomized patients in total) are planned and seem logistically feasible at the study center. Thus, we expect to have at least 15 patients aged 18 to 75 years per group at week 6.