Ethical Considerations
The Medical Research Ethics Committee of the University Medical Center Utrecht in the Netherlands approved the study protocol (18-085/D), and the study was registered at the onset of patient enrollment (ISRCTN 94074203). All participants provided written informed consent before their inclusion and took part voluntarily. The study data were handled anonymously. The trial was reported according to the CONSORT (Consolidated Standards of Reporting Trials) statement for cluster randomized trials (