Statistical analysis
All statistical analyses were analyses based on intention to treat analysis using STATA version 16.1 (Stata Corp. Texas, USA). Baseline characteristics and outcomes of interest were described based on the mean, median, standard deviation (SD) and percentage. Continuous variables between the two groups were compared, and the differences were analyzed with either unpaired t-test or Fisher’s exact test. For non-normally distributed variables, Mann–Whitney U test was used. 