Patient disposition
In the SAD phase of Study 1, 70 patients were randomized and treated in 8 countries: United Kingdom (n = 16), Panama (n = 13), Thailand (n = 13), France (n = 10), Chile (n = 6), New Zealand (n = 6), Colombia (n = 5), and Australia (n = 1). Of these, 53 were randomized to 1 of 4 doses of lumicitabine (1.37 mg/kg, n = 18; 4.1 mg/kg, n = 18; 12 mg/kg, n = 14; 25 mg/kg, n = 3), while 17 were randomized to placebo. In all, 66 patients completed the SAD phase of the study (