Author contributions
C.-S.Q. and S.J. designed the study, analyzed and interpreted the data, revised, and approved the manuscript. S.-J.X., M.-F.F., and L.C. wrote the manuscript. S.-J.X. and L.C. collected, analyzed, and interpreted the clinical data. M.-F.F. did the experiment, analyzed and interpreted the basic data. S.-J.X., M.-F.F., and L.C. contributed equally to this work. Z.F., J.-D.F., G.-W.X., H.L., Z.-L.P. provided samples or interpreted clinical data or both. L.-W.Y. advised on the conception and design of the study and revised the manuscript. All authors were responsible for the final review and approval of the manuscript.