Study design and setting
This study is a single blinded, three-arm, randomized, placebo-controlled, clinical trial that was designed and reported by adhering to the Consolidated Standards of Reporting Trials statement CONSORT [Consolidated standards of reporting trials flow diagram of the studyThe study population was recruited from the outpatient Endodontic clinic at Faculty of Dentistry, Ain Shams University, between July 2017 and January 2020. All applicants signed a consent after a detailed description of the study’s aim, methods, advantages, and possible hazards.