ACKNOWLEDGMENTS
This research was supported by the Inner Mongolia Science and Technology Major Projects (2021ZD0014), the National Natural Science Foundation of China (31720103911), and the earmarked fund for CARS36.We extend our thanks to Wuhan Metware Biotechnology Co., Ltd., for helping in metabolite detection and Novogene Co., Ltd., for helping in metagenomic sequencing.Zhihong Sun and Heping Zhang, conceptualization and design of methodology. Ye Chen, clinical trial implementation and specimen collection. Xin Shen and Teng Ma, formal analysis, data curation, visualization, and writing of the original draft. Xia Yu and Yalin Li, formal analysis and software testing and verification. Lai-Yu Kwok, writing, critical evaluation, and revision of the original draft and resource provision. Dongmei Li, supervision of the clinical trial and manuscript revision. Heping Zhang is the guarantor of this work and, as such, had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.We declare no conflicts of interest.