Author contributions
PRS
RM designed the trial. YJ was responsible for the statistical analysis of the data. TRM was responsible for the genetic analysis plan. ML designed the population-specific genetic variant panel. TM assisted with genetic analysis of the data. RM and PRS obtained funding. RB, RY, RT-C, KS, GD, KAM, RD, PC, AM, NN, FK, JH, BO-W, and RP were responsible for trial implementation and data acquisition. RB and RM wrote the first draft of this manuscript and RM handled the revisions. All authors reviewed the manuscript and approved the final version for submission.