Statistical analyses
REGRESSION
We summarized the assessed variables using the mean and standard deviation or percentage (%) using Student’s t-test or Fisher’s exact test where appropriate. A multivariable linear regression using age, gender, TIT, and the anesthetic agent used was utilized to determine factors that affected postoperative peak levels of AST and ALT. Confidence intervals (CI) of hazard ratios (HR) were estimated at 95%. All outcomes were analyzed according to the intention-to-treat analysis.Additionally, as a sub-analysis, all outcomes were analyzed according to the per-protocol effect. A p-value less than 0.05 was considered to be statistically significant.All analyses were performed with EZR (Saitama Medical Center, Jichi Medical University, Saitama, Japan), a graphical user interface for R (The R Foundation for Statistical Computing, Vienna, Austria) [