Methods
We performed an open, single-centre, prospective, single-arm phase I/II clinical trial (EC Code: CSM/FAP/2012–EudraCT: 2013-000535-27). The trial was reviewed and approved by the Ethics Committee at Salamanca University Hospital and the AEMPS (Institutional Review Board protocol number: 13/1005). All patients signed the approved informed consent form, and all the procedures where in accordance with the principles of the Declaration of Helsinki.Additionally, perioperative and long-term outcomes of two additional patients treated with MSCs after lung resection under compassionate use, outside of the clinical trial but with the same inclusion and exclusion criteria (see next section), were evaluated.