Introduction
NAFLD, Radix glehniae, obesity, Paeoniae Radix Alba, Radix Bupleuri, Fuling, metabolic diseases, liver reaction, Atractylodis Macrocephalae Rhizoma, metabolic syndrome, steatosis, TCM, diabetes
OBESITY, DISEASE, NON-ALCOHOLIC FATTY LIVER DISEASE, METABOLIC DISEASES, METABOLIC SYNDROME, STEATOSIS, DIABETES
Non-alcoholic fatty liver disease (NAFLD), is common disease characterized by steatosis in more than 5% of hepatocytes with no excessive alcohol consumption, and is a form of liver reaction to a metabolic syndrome (In recent years, Traditional Chinese Medicine (TCM) has been favored by a growing number of patients because of its good efficacy with few side effects. There is a promising development and application prospect in the prevention and treatment of NAFLD with TCM, and definite curative clinical efficacy has been achieved. Spleen-strengthening and liver-draining formula (SLF) is a formula formed according to the theory of “One Qi Circulation” of TCM, which originated in the Qing Dynasty (in 1749). SLF is composed of Radix Bupleuri (Chaihu) 9g, Paeoniae Radix Alba (Baishao) 10g, Radix glehniae (Beishashen) 15g, Atractylodis Macrocephalae Rhizoma (Baizhu) 10g, Poria cocos (Fuling) 10g, Citrus Reticulata (Chenpi) 9g, Radix Glycyrrhizae preparate (Gancao) 6g, Sedum sarmentosum (Chuipencao) 15g, Carbonized hawthorn (Shanzhatan) 9g, Salvia miltiorrhiza (Danshen) 15g. In a preliminary clinical observation, SLF showed significant therapeutic effects in patients with NAFLD, including their levels of liver function, blood glucose, and lipids, as well as TCM symptoms.Recent studies have shown that the imbalance of intestinal flora was closely related to metabolic diseases such as NAFLD, diabetes, and obesity (In this study, we observed the clinical therapeutic result of SLF based on a prospective, randomized, controlled clinical study, and the effect of SLF on intestinal flora of NAFLD was analyzed by 16S rRNA gene sequencing, to further clarify the mechanism of SLF in the treatment of NAFLD.