Migraine frequency and severity
Headache, MH, ketosis, pain, bodily pain, migraine, Migraine
MIGRAINE, MIGRAINE, KETOSIS
At week 8, patients on VLCKD showed a statistcally significant greater reduction in MMDs compared to HBD (− 6.4 ± 4.8 vs − 2.2 ± 5.0, p = 0.008). Importantly, MMDs reduction remained significantly higher in patients allocated to the VLCKD group also after stopping ketosis by carbs reintroduction (week 12: − 7.2 ± 5.42 vs − 3.13 ± 3.58, p = 0.007), and when patients were shifted to HBD (week 24: − 6.8 ± 6.42 vs − 3.6 ± 3.3, p = 0.042) (Tables Comparison of anthropometric data and questionnaires scores between week 8 and week 0 (data expressed as ∆)BMI, body mass index; WC, waist circumference; HC, hip circumference; BP, blood pressure; MMDs, monthly migraine days; MIDAS, Migraine Disability Assessment Scale; HIT-6, Headache Impact Test; VAS, Visual Analogue Scale; SF-36, Short Form Health Survey; SF-36 PF, physical functioning; SF-36 RP, role—physical; SF-36 BP, bodily pain; SF-36 GH, general health; SF-36 VT, vitality; SF-36 SF, social functioning; SF-36 RE, role—emotional; SF-36 MH, mental healthWe highlighted with * significant differences between baseline and week 8 in each groupAll values are presented as mean ± standard deviation, or percentage. Differences were considered statistically significant when Comparison of anthropometric data and questionnaires scores between week 12 and week 0 data (expressed as ∆)11.42 ± 12.77* p = 0.00532.14 ± 45.39* p = 0.02011.57 ± 18.82*p = 0.0397.07 ± 7.95* p = 0.0059.64 ± 11.84*p = 0.00916.0 ± 22.66*p = 0.0228.71 ± 41.07*p = 0.021BMI, body mass index; WC, waist circumference; HC, hip circumference; BP, blood pressure, physical functioning (PF), role—physical (RP), bodily pain (BP), general health (GH), vitality (VT), social functioning (SF), role—emotional (RE), and mental health (MH). We have highlighted with * the significant differences between baseline and week 12 in each groupAll values are presented as mean ± standard deviation, or percentage. Differences were considered statistically significant when Figure Variations in monthly migraine days (MMDs) in VLCKD and HBD groups at weeks 0, 8, 12 and 24 (V2, V5, V6 and V7)No significant differences were observed for migraine severity (p = 0.773; 0.632) between groups at week 8 and 12 when compared with week 0 (Tables 