Implicit time.
RP
DISEASE, FLICKER, RETINA
It has long been known that in normal individuals, the retina produces slower electrical responses to dimmer light stimuli (There have been hints that a slower (larger) implicit time corresponds to worse disease, for example in sector RP, in which some quadrants of the fundus appear to be normal. When the implicit time is normal or near normal, sector RP has a stationary or more slowly progressive phenotype. However, patients with very delayed cone flicker implicit time, even if the fundus appears to have “sector RP,” have the progressive form of RP (This study validates the use of the cone flicker implicit time as an important biomarker in the rate of progression of RP (Some previous studies have investigated the cone flicker implicit time as an outcome measure, rather than a predictor of disease (