Results
intercurrent illness, traumatic
WASTED, EVENT
Out of 91 patients eligible to participate in the study, 11 patients did not complete the baseline evaluation and one patient did not meet inclusion criteria. Thus, 79 patients were randomized to either HBOT or sham arms. Two patients from the sham group withdrew their consent during treatment, and two patients did not complete the post-protocol assessments due to poor compliance. From the HBOT group, three patients did not complete post-protocol assessments due to intercurrent illness, a personal traumatic event, and withdrawal of consent. Accordingly, 37 patients from the HBOT group and 35 patients from the sham group completed the protocol and underwent post-treatment assessments. Six echocardiography examinations from the HBOT group and 4 from the sham group were not transferred appropriately and saved for analysis. One exam from each group was not suitable for speckle tracking imaging analysis due to suboptimal quality. Figure Patient flowchart.Patient baseline characteristics are detailed in Table Patient characteristics.BMI, body mass index; BSA, body surface area; PCI, percutaneous coronary interventions; ACE, angiotensin converting enzyme.Conventional echocardiography parameters including ejection fraction (EF), LAVi, LVMi, diastolic function, and pulmonary artery pressure were similar between both groups (Baseline echocardiography and hemodynamic parameters.HR, heart rate; SBP, systolic blood pressure; DBP, diastolic blood pressure; LAVi, left atrial volume index; PAP, pulmonary artery pressure.Speckle tracking imaging parameters are presented in Table Myocardial work index changes.GLS, global longitudinal strain; GWI, global work index; GCW, global constructive work; GWW, global wasted work; GWE, global work efficacy.*p—the significance of baseline differences.Significant values are in bold.Post-hoc analysis was performed on the subgroup of patients with reduced GLS at baseline defined as lower than − 20% (Table Myocardial work index parameter changes in patients with reduced GLS.GLS, global longitudinal strain; GWI, global work index; GCW, global constructive work; GWW, global wasted work; GWE, global work efficacy.Significant values are in bold.Global longitudinal strain in the group of patients with reduced strain at baseline. GLS improved in both groups of patients with reduced strain at baseline. In patients that underwent HBOT, GLS improved significantly.Global longitudinal strain and myocardial work index parameters before and after the HBOT in a 45-year-old patient. (The data were analyzed by ML blindly. Interobserver and intraobserver variabilities (ML and VT) were done on 20 random study patients and were both found to range up to 5%.