Ethics approval
The study received ethical approval from a central Institutional Review Board in the US (Pro00022375, July 26, 2017) and the Assuta Health System Ethics Committee/Institutional Review Board (#2016028, July 23, 2017) in Israel. All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and its later amendments. This study does not contain any studies with animal subjects performed by any of the authors. 