Principal stratum estimand
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EVENTS, EVENT
A principal stratum strategy to handle intercurrent events implies interest lies in the treatment effect in the subpopulation of participants who would (or would not) experience the intercurrent event.The estimand can be written as
where We note that the definition above primarily focuses on how the intercurrent event ‘failure to initiate treatment’ is handled; the other aspects which make up the estimand (population, treatment conditions, endpoint, summary measure, and handling of other intercurrent events) would also need to be specified in order for the estimand to be complete.