Ethical approval and consent to participate
We confirm that all methods were carried out following relevant guidelines and regulations. The ethical approval was obtained from the Ethical Review Board (ERB) of the Nepal Health Research Council (NHRC), Nepal (Reg. Number: 3322, approved on 06/06/2021). The clinical trial registry was done with Clinical Trial.gov (Identifier: NCT04985396), registered on 02/08/2021). Participants were recruited under study only after obtaining written consent. Those patients who provided written informed consent were included in the study.