Objective
hyperandrogenism, PCOS, preeclampsia
OF PREGNANCY COMPLICATIONS, IUGR, POLYCYSTIC OVARY SYNDROME (PCOS), INTRAUTERINE GROWTH RESTRICTION, PRETERM DELIVERY, HYPERANDROGENISM, PREECLAMPSIA
Serum prokineticin-1 (s-PROK1) in the second and third trimester of pregnancy is positively correlated to preeclampsia, intrauterine growth restriction (IUGR) and preterm delivery. Women with polycystic ovary syndrome (PCOS) are prone to these adverse pregnancy outcomes. However, the contribution of PROK1 to the development of pregnancy complications and the effect of metformin and hyperandrogenism on s-PROK1 in PCOS have not been studied previously.