Measurements
BLOOD
Blood samples were obtained at baseline and after 24 months, with the exception of the UA level, which was measured at baseline, 6, 12, and 24 months. The SUA and LDL‐cholesterol (LDL‐C) concentrations were quantified at each local site, and the MDA‐LDL level was measured at a centralized laboratory (SRL Co.). For the measurement of MDA‐LDL levels, an enzyme‐linked immunosorbent assay (Oxidized LDL ELISA Daiichi; SEKISUI) was employed.The detailed protocol and procedure for measuring carotid IMT were described previously.