Total MADRS score changes over time for participants. Abbreviation: MADRS—Montgomery-Asberg Depression Rating Scale.
MDD, ideation
REMISSION
For the prevalence of positive response (≥ 50% reduction in individuals’ baseline MADRS score from study commencement) by participants over the study course, using the total MADRS score, five out of 10 participants (50%) had positive responses during the week of having received ketamine infusion, with two participants having sustained positive response on day 7 after the infusion. All five positive responses occurred with the 0.1mg/kg dosing. As clinical deterioration from underlying life-limiting illnesses can mimic somatic items of MDD, on excluding the somatic MADRS items, there were more participants with positive responses (six of ten). Three of the six participants who developed positive responses during the week had sustained positive responses on day 7 post-infusion. For suicidal ideation (MADRS item 10), nine of ten participants had a ≥ 50% reduction in baseline suicidal ideation during the intervention week. Seven of these nine participants had sustained ≥ 50% reduction in baseline suicidal ideation on day 7 post-infusion.Three participants achieved remission (MADRS ≤ 9) throughout the study. Out of these, two relapsed (MADRS ≥ 16) within seven days of remission.