Correlation of response by dose level analysis
PD
To determine whether the observed effects are related to dose of RRx-001 when combined with PD-1 blockade, a Spearman product-moment correlation analysis between response (converted to a categorized variable where 1 = PR, 0 (= SD or PD or NE) is carried out, and the resulting correlation estimate is approximately 12.6% (p = 0.6973, Spearman product-moment test, an insignificant result). The limitations of the sample size in this pilot study makes the Spearman correlation analysis results a challenge to interpret, and a future study to test the reliability of such analyses is necessary.