Subgroup Analysis and Outcomes
leaks, BPD, nasal skin injury, weight gain
NECROTIZING ENTEROCOLITIS, INTRAVENTRICULAR HEMORRHAGE, SECONDARY, EVENTS, RETINOPATHY OF PREMATURITY
According to the predefined criteria,For the subgroups of interest, we analyzed and reported the same co–primary outcomes chosen for the whole trial: (1) total duration of IMV during the NICU stay, (2) need for reintubation (criteria for reintubation were fixed and described in the protocolFor the whole population, we also analyzed secondary efficacy (ie, prevalence of BPD and moderate-to-severe BPD, use of postnatal steroids, in-hospital mortality, and a BPD-mortality composite end point) and safety, including prevalence of air leaks and apneic events, patient comfort, weekly weight gain, prevalence of severe nasal skin injury, grade III to IV intraventricular hemorrhage, stage II to III necrotizing enterocolitis, and retinopathy of prematurity, if retinopathy of prematurity grade was more than 2 outcomes. The definitions and monitoring strategies for these outcomes were previously described.