Patients
tumor, IgAN, primary glomerular disease, infection, non-IgAN, TG
RENAL, TUMOR, RECRUITMENT, MAY, INFECTION, SECONDARY GLOMERULAR DISEASE, URINARY TRACT OBSTRUCTION, REGRESSION, -11, RENAL ARTERY STENOSIS, AUTOIMMUNE DISEASE
This prospective research conformed to the guidelines of the Declaration of Helsinki and was approved by the Internal Review Committee (PJ2022-11-29). Written informed consent was obtained from each study participant.We continuously recruited 120 patients with primary glomerular disease confirmed by biopsy as research subjects between May 2022 and December 2022. We assigned them to two cohorts: the IgAN and the non-IgAN cohorts. Renal biopsy was performed within 3 days after renal ultrasound measurement by two experienced nephrologists. The right kidney was selected for renal biopsy. The inclusion criteria were as follows: 1) the diagnosis of primary glomerular disease confirmed by renal puncture biopsy of at least ten glomeruli in the specimen visible under a light microscope; 2) age >18 years; and 3) < 5 cm distance between the kidney and the skin. The exclusion criteria were as follows: 1) secondary glomerular disease; 2) diagnosis of infection, tumor, or autoimmune disease; 3) renal artery stenosis or urinary tract obstruction; and 4) presence of kidney cysts or tumor. The process for case selection is shown in The patient Recruitment pathway and the inclusion and exclusion criteria.We collected data on age, sex, mean blood pressure, red blood cell count, white blood cell count, hemoglobin (Hgb) levels, platelet count, neutrophil percentage, alanine aminotransferase (ALT) levels, aspartate aminotransferase (AST) levels, alkaline phosphatase (ALP) levels, total protein (TP) levels, albumin (ALB) levels, lactate dehydrogenase (LDH) levels, creatinine (CRE) levels, uric acid (UA) levels, estimated glomerular filtration rate (eGFR), urea (UREA), total cholesterol (TC) levels, triglyceride (TG) levels, high-density lipoprotein cholesterol (HDL-C) levels, low-density lipoprotein cholesterol (LDL-C) levels, immunoglobulin G (IgG) levels, IgA levels, immunoglobulin M (IgM) levels, complement C3, urine occult blood, and 24-h urine protein.Single-factor logistic regression analysis was used to analyze the correlation between clinical parameters and IgAN. Then multi-factor logistic regression analysis was performed on the relevant factors (