Hyperhydration
STEC, hyperhydration
SECONDARY, COMPLICATION
Data related to all intravenous fluids administered will be extracted from the medical record. For the calculation of pathway adherence, the intravenous fluid administration period begins (i.e., time of study initiation) at the:Time of hospital admission plus 2 h (for participants asked to come to the hospital)* ORTime the participant met eligibility criteria plus 2 h (for participants already in hospital)* ORActual time of initiation of intravenous fluid administration if occurs before the additional 2-h period has lapsed*Some participants will be admitted into the hospital before eligibility, and some will become eligible before admission (i.e., positive STEC result in child who is at home). The later of the time points between options (1) and (2) will be used to determine the timing of study initiation if (3) does not apply.The intravenous fluid administration period ends (i.e., time of study end for pathway adherence determination) when any fluid protocol termination criteria are met (i.e., weight/hematocrit targets, complication ensues, end-of fluid protocol criteria) or after 48 h of fluid administration—whichever happens first. The targeted volume of fluid is defined by the administration of ≥ 175% of maintenance fluids calculated according to the Holliday–Segar formula for the duration of time the participant was in the volume expansion phase of the protocol [The management of patients who receive < 175% of maintenance intravenous fluids in the hyperhydration arm will be classified as nonadherent. However, all patients will be included in the intent-to-treat (ITT) analyses regardless of the volume of fluids administered; secondary analyses will include a per protocol adherence analysis.