Statistical analysis
All statistical analyses were conducted using Graphpad Prism 9.5.0 at an alpha level of 0.05. Prior to conducting statistical analyses, normality assumptions were assessed using the Shapiro–Wilk test. The Shapiro–Wilk test was conducted on the data collected from the two arms of the trial. A p-value of less than 0.05 was considered to indicate a departure from normality. If the normality assumption was not met, non-parametric tests were used for subsequent statistical analyses.To test for differences in normal datasets, Unpaired T-test was conducted for intergroup analysis and repeated measures one-way ANOVA, with post-hoc Tukey multiple comparison test was used to test differences across multiple timepoints within each arm of the trial.To test for differences of non-normal datasets, a Mann–Whitney test was conducted intergroup analysis and a Friedman test, with post-hoc Dunn’s multiple comparison test was used to investigate significant difference in the medians of the variable across the different time points of each arm of the trial.