Statistical analysis
NRS, fever
SECONDARY, SURGICAL SITE INFECTION
On the principle of the intention-to-treat principle, all analyses were performed. All patients who were randomly assigned were included in the intention-to-treat group. The primary outcome was the CD4+/CD8 + ratio 24 h after surgery, while the secondary outcome measures were the number of lymphocyte subsets, intraoperative awareness, emergence time, NRS score, and analgesic pump drug residual volume at 24 h after surgery, as well as the incidences of surgical site infection and fever during hospitalization. According to the published data [Statistical analysis was performed using the SPSS software (Version 19.0; IBM Corporation, New York). The normality of data distribution was assessed by the Shapiro-Wilk test. Normally distributed continuous data were expressed as the mean ± standard deviation and analyzed using the t-test. The categorical variables were expressed as frequencies (percentages) and analyzed using the chi-square test. The Mann-Whitney U-test was used for continuous variables with a non-normal distribution. The differences in T lymphocyte subsets and NK cells over time were analyzed by Two-way analysis of variance (ANOVA) followed by Bonferroni correction. Statistical significance was set at 