Conclusions
The tau-PET tracer MK6240 suffers from OTS in the meninges and this signal contaminates cortical regions and the cerebellum. In addition to our standard MRI-guided PET processing, we examined 6 alternative approaches designed to reduce the effect of OTS on target region quantification. Our efforts revealed that none of the alternative processing approaches we tested improved effect sizes for key associations between MK6240 target region SUVR and age, sex, and A 