Primary outcomes
HIV infection
HIV INFECTION
There are 3 co-primary outcomes: 1) effectiveness of the intervention in reducing the prevalence of sexually transmissible HIV; 2) uptake of universal risk informed HIV prevention intervention, in particular PrEP; 3) cost of transmissible HIV infection averted.We will measure transmissible HIV as the proportion of participants aged 16–30 years providing a blood sample at endline who are living with HIV and have a detectable HIV viral load of ≥ 400 copies/mL. This composite outcome captures the effect of the intervention on both incident HIV and untreated HIV. Success of our intervention implies that there will be fewer cases of young people who acquire HIV, and those who do acquire HIV will be identified and started on treatment, both of which will reduce the number of individuals with unsuppressed (transmissible) HIV.We will measure the uptake of universal risk informed HIV prevention intervention as the proportion of participants who are aware of their HIV status and are either on treatment if living with HIV or have taken up PrEP if HIV negative and eligible. We will measure the costs to the provider or healthcare system for each participant screened, enrolled and retained on PrEP per covered month. We will compare the costs of care in the intervention and control periods to determine the cost-effectiveness of the intervention in achieving the endpoints, i.e., the cost per transmissible HIV case averted, the cost per case linked to risk differentiated biosocial HIV prevention, cost per case linked to PrEP.