vlPAG seed‐based functional connectivity analysis
KOA knee pain
REGRESSION
Functional BOLD information was pre‐processed using DPARSFA (Data Processing Assistant for Resting‐State fMRI, Advanced)A priori vlPAG seed with the following peak coordinates: 4, −26, −14, and a 3 mm radius was utilized. This seed was already utilized in earlier investigations.From the vlPAG seed, the averaged time course was derived, and a voxel‐wise correlation analysis was performed. By applying the regression coefficient between all brain voxels and the time sequence of each seed, contrast pictures for each individual were created. Furthermore, the correlation coefficient map's normality was enhanced by applying Fisher's r‐to‐z transform. The baseline vlPAG rs‐FC of KOA knee pain patients and healthy controls were compared by employing a two‐sample 