Limitations
TBI sequelae, intracranial injury, TBI, intracranial damage
This study has several limitations. It is important to emphasize that only participants with a radiologically verified intracranial injury were included. The eligibility criteria only allowed inclusion of patients with the capacity to contribute to goal setting and with self-reported TBI-related symptoms. Hence, results might not be applicable to patients with mild TBI without intracranial damage or patients with severe difficulties in awareness and cooperation in goal-setting procedures. Both primary outcomes may have been affected by the COVID-19 pandemic, but other findings nonetheless indicate effectiveness. Although this is one of the larger trials of individualized home-based rehabilitation in chronic TBI sequelae to date, the sample size is nonetheless limited. Both the sample size and the multiple outcomes applied in this trial entail a risk of both type 1 and type 2 errors. Lack of an active control group and exposure to follow-up in the control group (baseline interviews and reports to the participant’s general practitioner) could potentially bias results.