Conclusions
Acupuncture, knee osteoarthritis, pain, KOA, KOA knee pain, knee pain
KNEE OSTEOARTHRITIS
Acupuncture treatment, celecoxib, and placebo medication have different modulation effects on vlPAG DPMS in KOA knee pain patients. Acupuncture could modulate vlPAG rs‐FC with brain regions associated with cognitive control, attention, and reappraisal for knee pain relief in KOA patients, compared with celecoxib and placebo medication.Acupuncture treatment, celecoxib, and placebo medication have different modulation effects on ventrolateral periaqueductal gray (vlPAG) descending pain modulation system (DPMS) in knee osteoarthritis (KOA) knee pain patients. Acupuncture could modulate vlPAG resting‐state functional connectivity (rs‐FC) with brain regions associated with cognitive control, attention, and reappraisal for knee pain relief in KOA patients, compared with celecoxib and placebo medication.
Jun Zhou and Fang Zeng contributed equally to this work.