Results
delirium, bradycardia, tachycardia, SD, hypoxemia, non-delirium, hypotension, hypertension, NRS
ADVERSE EVENTS, HYPERTENSION, COMPLICATIONS
Between November 2016 and October 2020, 300 patients were eligibility for study participation; 60 patients were excluded and 240 patients were enrolled to the study. They were randomly assigned to receive either DEX or normal saline. Four patients were excluded from the study because they did not cooperate to complete the POD assessment, and finally, 236 patients completed the study Fig. Flow diagram of patients through the studyPerioperative variablesDate are number (%), mean (SD). BMI: body mass index, ICU: intensive care unitIn our trial, postoperative delirium occurred in 14 of 236 patients (12 in group C and 4 in group D). The incidence of POD in group C (10.1% vs 3.4%) was higher than that in group D (Effectiveness outcomesData are mean ± SD, number (%), median (IQR). POD: Postoperative delirium, NRS: numerical rating scale; *The incidence of bradycardia, tachycardia, hypotension and hypoxemia did not differ between the two groups, the same as the difference in the situation requiring intervention for the above adverse events. Meanwhile, the incidence of hypertension was significantly lower in the group D (Safety outcomesData are number (%); *The incidence of non-delirium complications was similar between the two groups, and the difference was not significant (Table Non-delirium complicationsData are presented as number (%)