Statistics
fracture, fractures
REGRESSION
All data were described with suitable measurements of central tendency and dispersion. All confidence intervals (CIs) presented are 95% confidence intervals.Data were analyzed for all fractures as a whole, as well as separately for the upper and lower extremities. All statistical tests were performed with a two-sided significance level of 5%. No correction for multiple testing was performed due to the non-confirmatory design.All endpoints were evaluated in the modified intention-to-treat (mITT) population, which includes all patients who underwent surgery because of their fracture in the group they were allocated to by randomization. Patients who underwent conservative treatment after randomization and therefore did not reach the primary endpoint were excluded from analysis. For the primary endpoint, additional sensitivity analyses were performed in the as-treated (AT) population. In the sensitivity analysis, patients were allocated to the intervention group or control group according to the protocol they were treated after mainly (AT), correcting for treatment changers from the intervention group to the control.Multiple linear regression was performed to analyze a possible influence of the demographic variables (a) age, (b) gender, (c) education level, (d) comorbidities, (e) smoker, or (f) affected side on the primary endpoint.Interval scaled variables were analyzed using Welch’s t-test. Ordinal scaled variables were analyzed using the Mann–Whitney U test with continuity correction. Fisher’s exact test was used in the case of categorical variables.The evaluation was carried out using the program R in version 3.6.3.The graphics were created in Prism program from GraphPad Software, version 8.3.1.