Background
Frailty, pancreatic cancer
DISEASE, DISEASES, PANCREATIC CANCER, SECONDARY
The incidence of pancreatic cancer (PC) is increasing and PC is one of the most lethal diseases. In the United States, PC is currently ranked as the 4The majority of PC patients are diagnosed in a non-resectable stage; 30% in a locally advanced and 50% in a metastatic stage [Hampering the potential benefit of more intense treatment, patients with PC very often present with affected overall health status, either secondary to the disease or because of comorbidities [Frailty increases with age due to increased prevalence of comorbidities, polypharmacy, and compromised organ function, and in the Danish population one fifth of patients treated with chemotherapy for PC are ≥ 75 years [In conclusion, improvements in the prognosis of PC in the growing vulnerable population are highly needed and an approach to improve tolerability and efficacy of treatment could be dose reduction of combination chemotherapy [