HVF Analysis
To detect pointwise change over the course of the study, the points were categorized by individual pointwise retinal sensitivity at baseline. The mean change in sensitivity was plotted at each point from baseline to 12 and 24 months. Subsequently, the cohort was restricted to a population defined by a baseline MD between −2 dB and −7 dB to simulate a medically managed population. Finally, the number of points in the visual field in the whole cohort and in the restricted simulated medically treated cohort that would be expected to change per sensitivity category were calculated.