2.1. Study design and population
necrosis, lower extremity infection, mental illness, liver and kidney dysfunction, septicemia, edema, heart valve disease, LEAOD, sepsis, injury syndrome
ULCERATION, SEPTICEMIA, DISEASE COURSE, EDEMA, DISEASE, HEART VALVE DISEASE, ACUTE CORONARY SYNDROME, NECROSIS, SEPSIS
This research was approved by the Medical Ethics Committee. A retrospective analysis was performed on 92 patients with LEAOD admitted to our vascular surgery department from November 2020 to December 2022. Patients were divided into a control group and an experimental group, each consisting of 46 individuals (Fig. Flow diagram of the study design and population.Inclusion criteria encompassed those who (1) met the diagnostic criteria for LEAOD through angiography, magnetic resonance angiography, color Doppler ultrasound, and serum lipid laboratory examination; (2) had Fontaine stage I to III disease; and (3) had complete clinical data and signed an informed consent form. Exclusion criteria included: (1) a family history of severe mental illness within the last 3 generations; (2) severe lower extremity infection leading to sepsis or septicemia; (3) concomitant severe heart valve disease, acute coronary syndrome, severe liver and kidney dysfunction or frostbite injury syndrome; and (4) severe necrosis, edema, or ulceration of the lower limbs. No statistically significant differences in age, gender, disease course, or Fontaine staging were found between the 2 groups (Comparison of baseline characteristics between control and experimental groups.