3.3.3. Proportions of patients in histological remission among CDC achievers vs non-achievers
INFLAMMATORY BOWEL DISEASE, DISEASE, REMISSION, DISEASE
To assess the relationship between achievement of CDC and histomorphology [as an objective marker of disease activity], the proportions of patients who did and did not achieve CDC who were in histological remission were investigated. At week 10, greater proportions of CDC achievers than non-achievers were in histological remission [biologic-naïve: 75.5% vs 21.4%; biologic-experienced: 57.1% vs 14.2%; both Proportions of CDC achievers and non-achievers in histological remission in Induction Studies A and B [A–C] at week 10, and in the Maintenance Study at week 58 [D]. CDC was defined as achievement of pMCS remission, endoscopic improvement, inflammatory biomarker remission and IBDQ remission. Histological remission was defined as a grade 0 Geboes score of ≤0.3, grade 1 score of ≤1.1, grade 2A score of ≤2A.3, grade 2B score of 2B.0, grade 3 score of 3.0, grade 4 score of 4.0 and grade 5 score of 5.0. CDC, Comprehensive Disease Control; IBDQ, Inflammatory Bowel Disease Questionnaire; pMCS, partial Mayo Clinic Score.