Conclusion
delirium, critically ill, coma
CRITICALLY ILL, COMA, SECONDARY
This trial, that was stopped early, did not show evidence that haloperidol reduces delirium and coma in critically ill patients with delirium. The beneficial effects on some agitation-related outcomes and lower sedative requirements reported in a clinical trial are novel, clinically relevant and in line with clinical use. Together with some other signals of possible benefit in not previously reported (secondary) outcomes, these findings argue for additional effectiveness research of haloperidol for ICU delirium.