Funding
The trial was supported by a UK Medical Research Council Developmental Pathway Funding Scheme award (MR/K015524/1). The funder played no role in the collection, analysis or interpretation of data, writing of the report or the decision to submit for publication. This work was supported in part by grant MR/N0137941/1 for the GW4 BIOMED MRC DTP, awarded to the Universities of Bath, Bristol, Cardiff, and Exeter from the Medical Research Council (MRC)/UKRI.