Introduction
psychotic disorders, psychosis
REMISSION
Patients with psychotic disorders wish to have a chance to withdraw from antipsychotics entirely after achieving symptom remission (Perkins et al., While McGorry, Alvarez-Jimenez, and Killackey (To mitigate such an undesirable tradeoff, we proposed an alternative approach beyond the dichotomy between maintenance and discontinuation of antipsychotics with a subtle yet pivotal fine-tuning of the attitude toward the role of antipsychotics in patients with remitted psychosis. That is, not aiming at complete medication discontinuation but anticipating a chance to reduce their antipsychotics to the lowest effective dose (Liu & Takeuchi, Previously, the minimum effective dose (MED) was estimated by the dose which could exhibit a differentiable effect of reducing symptom severities in randomized, double-blind, fixed-dose trials comparing antipsychotics to placebo (Leucht, Samara, Heres, & Davis, On the other hand, it would be unwise to reduce dose inadvertently, as dopamine supersensitivity-mediated relapse (Chouinard et al., Derived from such a notion, a protocol of guided antipsychotic reduction to reach minimum effective dose (GARMED) based on a pragmatic design was operationalized and employed in real world setting at the study hospital from 2017 (Liu et al., 