Background
knee OA, Osteoarthritis, OA, Pain, PNE, pain, musculoskeletal pain
OSTEOARTHRITIS
Osteoarthritis (OA) is a multifactorial widespread chronic rheumatic condition leading to difficulty performing daily activities [Different therapeutic exercise programs (e.g., aerobic, strengthening, or a combination of different types of exercise) have been introduced to improve knee OA [Pain neuroscience education (PNE) has been introduced as an effective intervention for improving patients' knowledge of pain, reducing pain and central sensitization and improving psychological factors [Prescribing exercise therapy and education were the most recommended interventions for improving musculoskeletal pain [Therefore, we aimed to conduct a randomized controlled trial (RCT) to provide pilot data investigating the effect of PNE followed by PEs in those who suffered from knee OA, compared to PEs alone. We hypothesized that participants receiving PNE followed by PEs would have superiority over those in PEs group to reduce pain and physical limitation, improve psychological factors, and improve function through eight weeks post-treatment.