Introduction
NLFs, alcohol abuse, granuloma
HYPERSENSITIVITY REACTIONS, SKIN, GRANULOMA
Skin aging is caused by genetic and environmental factors such as sun exposure, air pollution, smoking, alcohol abuse, and poor nutritionDermal fillers are commonly used for skin rejuvenation since they fill up wrinkles and replace soft-tissue volume lost due to agingAutologous fat transfer (AFT) is another treatment option. It does not produce hypersensitivity reactions and granuloma formation because of the biocompatibility of the adipose tissues usedIn 2011, the US FDA approved Laviv (Azficel-T; Fibrocell Technologies, Inc., Exton, PA, USA) as an autologous fibroblast tissue filler to improve moderate to severe nasolabial folds (NLFs) in adultsThe objective of this study was to compare the efficacies and safeties of autologous cultured fibroblast injections and HA fillers for treating NLFs.