Statistical analysis
All statistical analyses were carried out on an intent-to-treat basis with the baseline observation carried forward approach using IBM SPSS Statistics for Macintosh, Version 25.0. (IBM Corp. Armonk, NY, United States) and GraphPad Prism Version 6.01. (GraphPad Software, Inc., San Diego, CA). Chi-square test and Fisher’s exact test compared the baseline characteristics between the two groups. The assessment of interaction effects among baseline parameters was carried out by mixed factorial design ANOVA. For within-group analysis, paired t-test was used to study the difference between pre- to post-intervention for normally distributed data, or Wilcoxon signed-rank tests for continuous variables without normal distribution. For between-group analysis, the repeated measure ANOVA was used to study the intervention effects along with the interaction of time and group. A 