Authors’ contributions
SS, NU, EG, YP, CV, LP and TR conceptualized and designed the study. SS, GB, NU, AIP and DL contributed to the acquisition of data. SS, NU, CV and LP contributed to the analysis or interpretation of data. CV and LP contributed to statistical analysis, drafting of the manuscript and prepared figures, tables and supplement. EG, ZMH, AV contributed to MRI imaging processing, MRI statistical analysis and prepared figure S2. YP and JFB contributed to SPECT processing, SPECT statistical analysis and prepared figure S31-3. SS, NU, EG, YP, AF, CV, KL, TC, LP and TR contributed to critical review of the manuscript for important intellectual content. KL, TC, LP and TR contributed to administrative, technical, or material support. All authors read and approved the final manuscript.