Symptom severity change by low (2.5 mg, 5 mg) and high (10 mg, 20 mg) dose tamoxifen and stratified by menopausal status.
sweats, muscle cramps, night sweats
COLD
Sum of mean Likert score change is calculated from start to end of treatment, in symptoms significantly related to tamoxifen exposure regardless of menopausal status (hot flashes, cold sweats, night sweats, vaginal discharge, and muscle cramps). When comparing the proportion of women increasing in Likert score it could be seen that significantly fewer premenopausal women in the low-dose arm reported an increase in Likert score, regardless of the difference in score, compared to women randomised to 10 and 20 mg of tamoxifen (Supplementary Fig. 