Metformin reduced cellular senescence markers in muscle tissue and skeletal muscle 
tumor
TUMOR
The classical senescence markers, cyclin dependent kinase inhibitor 1a (CDK1NA; p21) and tumor protein p53 (TP53; p53) (Englund et al., Metformin decreased markers of cellular senescence in whole muscle and muscle resident fibro‐adipogenic progenitors (FAPs). CDK1NA (p21) transcription as a fold change from PRE, after bed rest (a) and after recovery (b). TP53 (p53) transcription as a fold change from PRE, after bed rest (c) and after recovery (d). (e) Correlation of mean myofiber area after bed rest to the fold change in p21 transcription after bed rest. (f) Correlation of Sirius Red percent area after recovery to the fold change in p21 transcription after recovery. (g) Representative images of senescent associated (SA)‐β‐galactosidase