Discussion
toxicity, hepatotoxicity
This study was initiated in 2014. Second-line standard treatment is still single-agent chemotherapy and 3In the present study the combination dose of P was adjusted to 240 mg/mAs expected, the ORR was low in each group, but the DCR was 56.2% and 36% in the combination and P only groups, respectively. Although the OS and PFS were similar in the ITT and PP populations, the absolute increased OS time in the ITT population was 4.1 months. Subgroup analysis also suggested that the RP regimen was favorable (The hematologic toxicity profile in the RP and P group was similar. The incidence of hepatotoxicity was higher in the RP group because of the combination of raltitrexed and P.The survival time in the monotherapy group was shorter than 3-4 months, as reported in the existing literature, likely because P was administered once every 3 weeks in the current study. A clinical study in which P-albumin was administered as 2