Author Contributions
M.M. and R.A.G. conceived and designed the original DINO trial; K.P.B. collected data for the original trial; M.M., R.A.G., A.W.G. and C.T.C. conceived and designed the 7-year follow-up study; K.P.B., T.R.S., R.A.G., C.T.C., J.F.G., M.M. and T.J.G. were involved in the data analysis and interpretation of the 7-year follow-up; T.J.G. and K.P.B. drafted the article. All authors were involved in critical revision and final approval of the version to be published. All authors have read and agreed to the published version of the manuscript.