Analysis of clinical parameters
At baseline, the values of all clinical parameters were comparable in all study groups.While from baseline to the end of month 3 all groups showed decreasing trends in the mean values of all recorded clinical parameters, Group 4 showed decreases in mean PI and GI scores from baseline to month 1, from baseline to the end of month 3—both of which were highly statistically significant—, and from month 1 to the end of month 3. In Groups 1, 2 and 3 there was a rise in mean values from month 1 to the end of month 3—and this rise was statistically significant in Groups 2 and 3 (
