Discussion
cancer, fracture, prostate cancer
BONE DISEASE, CANCER, DISEASE, ADVANCED CANCER, METASTATIC PROSTATE CANCER, PROSTATE CANCER
This study demonstrated that a 6-month aerobic exercise intervention was safe for a group of patients with a high burden of metastatic prostate cancer. While the exercise intervention did not show an effect amongst men with an already active lifestyle, the trial adds to the body of evidence examining the role of exercise for people with advanced disease.Treatment and disease-related side effects as well as fear of skeletal fracture are likely to reduce physical activity levels in patients with bone metastatic prostate cancer [The absence of changes in quality-of-life outcomes in ExPeCT may be due to a number of factors. In all domains of quality of life (emotional, physical, function, and social/family well-being), the patient population in the ExPeCT trial reported higher mean quality-of-life scores than those found in normative data of male patients living with cancer [Consistent with the results of other studies involving patients with advanced cancer, the ExPeCT exercise programme was well-tolerated by patients with metastatic bone disease, demonstrated by high adherence and low attrition rates [There were no changes over time in the anthropometric variables measured in the ExPeCT study. The impact of exercise on measures of body composition in men with prostate cancer is inconsistent [