Conclusions
amnestic, aMCI, cognitive impairment
Textural features of white matter in the frontal lobe showed potential for distinguishing aMCI from the normal population, which could be a surrogate protocol to aid aMCI screening in clinical setting.(a) Drawing regions of interest in frontal lobe using ITK‐SNAP. (b) Strategy for frontal lobe extraction from high‐resolution structural magnetic resonance imaging. (c) Intensity features and textural features were extracted from the images, and used the least absolute shrinkage and selection operator to choose the optimized subset of features to construct the final model. (d) Statistical analysis was used to find radiomic features. aMCI, amnestic mild cognitive impairment.

Wei Zheng, Ronghua Mu, and Fuzhen Liu have contributed equally to this work.