Study outcomes
SECONDARY
The primary outcome was the total urine output in the 24 h after commencement of the study drug infusion. All patients had an indwelling urinary catheter and their urinary output was recorded in the EMR by bedside nurses every hour. Such nurses were blinded to treatment allocation.Other secondary outcomes included changes in progressive cumulative UO, vasopressor requirements and sequential organ failure assessment (SOFA) score over time; time alive and free of vasopressors at day seven after study drug commencement, and alive ICU-free day. If a patient died, they were assigned zero alive and vasopressor-free or ICU-free days.Other outcomes included mortality at ICU discharge and hospital discharge, hospital length of stay, plasma ascorbate levels and inflammatory markers. We also assessed urine samples for the presence of urine oxalate crystals before the commencement of study drug infusion and at 24 h.