2.6. Toothpastes (blinded)
HYDROXYAPATITE
The test toothpaste and the active control toothpaste were provided in neutral plastic tubes all having the same shape; thus, both the subjects and the investigators were blinded. It is pertinent to mention that the subjects were requested not to discuss anything related to the toothpastes with any of the study team member who was involved in the clinical examinations. The neutral plastic tubes were labeled with a random subject number for each subject. The toothpastes were produced by an external certified laboratory. The composition of the toothpastes for both groups was identical (except for the main active ingredients, i.e., hydroxyapatite and fluoride). The compositions of the study toothpastes were as follows.