5. Conclusions
MM
DISEASE, REMISSION, OXIDATIVE STRESS
A decreasing trend in serum ferritin concentrations after Nordic walking training has been observed in patients with MM in remission taking part in this study, suggesting that the short duration of the training may not be sufficient to induce significant changes in ferritin concentrations.Intracellular changes in mRNA levels of genes related to iron metabolism showed a tendency towards decreased expression after Nordic walking training cycles, indicating an influence of the training on these genes.In conclusion, the results presented in this study suggest that the applied type of training may have beneficial effects in patients with MM. The moderate intensity exercise intervention applied in our study did not cause an increase in oxidative damage of macromolecules, which is a favorable effect. However, longer periods of training may be necessary to achieve significant favorable changes as observed in cited studies in healthy subjects. The present study provides further evidence that Nordic walking training is a safe form of physical activity for patients with MM in the disease remission phase, and as such should be recommended to patients. In our opinion, any treatment which induces decreases in genes and proteins associated with iron metabolism could be treated as positive and extend the period of remission, wherein a similar tendency refers to oxidative stress parameters. Thus, Nordic walking training is suitable for patients with MM; however, it is worth considering a longer period than 6 weeks of training.