Blinding description
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BLINDNESS
In this study, a trained nurse in the research team recorded demographic and clinical characteristics, outcome results, and randomized allocation to different groups. In the two groups receiving three-month injections, patients and observers (oncologist and nurse) were blinded to the administered drug. Blindness was not possible in the group of monthly drug injection for patients, the nurse and the oncologist. The analyzer was completely blinded to patients’ allocation to the three groups up to the end of the study.