Study outline
This study was a sub analysis evaluating the association between NADThe studies were approved by the Graduate School of Medicine and Faculty of Medicine, University of Tokyo Research Ethics Committee (2018013P) and registered as “Randomized, double-blind, placebo-controlled parallel-group comparative study to evaluate the effect of NMN on the body composition in elderly persons” at UMIN-CTR (UMIN000036321). 65 Japanese older men volunteers were recruited by NEWING NPO Corp (Tokyo, Japan), which is a third-party nonprofit organization. After some screening tests to assess eligibility for the NMN-supplementation study, in total 42 healthy Japanese men aged > 65 years were enrolled in this study. The details of the inclusion and exclusion criteria have been described in the previous study [All participants provided written informed consent to participate in the study. The study was conducted in accordance with the guidelines of the Declaration of Helsinki at the Clinical Research Support Center Phase 1 Unit of the University of Tokyo Hospital.