Chemotherapy Dose Intensity
To check that concurrent treatment did not diminish chemotherapy dose intensity received, it was calculated for 831 (36%) patients having 5740 cycles of chemotherapy (2913 cycles from 421 patients on the synchronous arm and 2827 cycles from 410 patients on the sequential arm). Overall dose intensity for all drugs combined across all cycles are reported in Overall dose intensity for all chemotherapy regimens used during SECRABCDDI, course-delivered dose intensity; CMF, cyclophosphamide, methotrexate, 5-fluorouracil; i.v., intravenous.