Statistical analyses
tumor
TUMOR
Efficacy and safety analyses of nivolumab plus ipilimumab versus chemotherapy in the randomized and treated populations, respectively, of Japanese patients were exploratory and summarized using descriptive statistics. Time-to-event analyses for OS, PFS, DOR, and TFI were performed using the Kaplan–Meier method. Hazard ratios (HRs) with associated two-sided confidence intervals (CIs) were calculated using a stratified Cox proportional hazards model, with tumor histology as the strata and treatment group as a single covariate. An unstratified model was used to estimate HRs between treatment arms in patient subgroups. The Clopper-Pearson method was used to calculate 95% exact two-sided CIs for ORRs.