Translational studies
peripheral blood)—including, tumor, breast DCIS, breast cancer
TUMOR, RECURRENCE, INVASIVE BREAST CANCER, BREAST CANCER, DCIS
Pathologically, tumor cells of DCIS are surrounded by a dynamic layer of ECM, including myoepithelial cells (MECs), basement membranes, immune cells, fibroblasts, and stroma [Regarding studies on the role of immune cells in the biology of breast DCIS [To evaluate the association between breast cancer susceptibility loci and the risk of DCIS, Campa et al. genotyped 39 SNPs correlated with the risk of invasive breast cancers in three groups, including 1,317 cases of breast DCIS, 10,645 cases of invasive breast cancer, and 14,006 healthy controls [Based on the aforementioned results, we will explore which biomarkers are associated with local recurrence of DCIS. The translation studies will be divided into three parts: (1) SNPs analysis (DNA extracted from mononuclear cells obtained from peripheral blood)—including 