Introduction
cSCC, cancer among kidney transplant, cutaneous squamous cell carcinomas
RECURRENCE, CUTANEOUS SQUAMOUS CELL CARCINOMA, METASTASIS, PROLIFERATION, DISEASE, METASTASES
Cutaneous squamous cell carcinoma (cSCC) is the most common cancer among kidney transplant recipients, with incidence rates up to 250 times higher than in general population and a higher risk of local recurrence, metastasis, and deathThe mTOR inhibitors (mTORi) have been shown to have anti-tumor effects by disrupting critical pathways of cell proliferation and angiogenesis, and by limiting the replication of certain oncoviruses such as HPVTherefore, this exploratory study investigated the disease modifying properties of conversion from CNI to SRL as an adjuvant cytostatic therapy for kidney transplant recipients with cutaneous squamous cell carcinomas designated as aggressive or high-risk cSCC, which has substantially higher rates of recurrence and metastases.