Discussion
ischemia
ISCHEMIA
The present study is, to our knowledge, the first-in-human assessment of targeted HD C-tDCS as a potential emergent therapy for AIS. Electrical current delivery used HD individualized montages predesigned to cover distinct ischemic territories due to occlusion of 6 major arteries in the anterior and posterior intracranial circulation. We found that HD C-tDCS can be efficiently deployed in hyperacute emergency and intensive care settings.We observed higher rates of penumbral tissue salvage and alleviation of hypoperfused ischemic regions in active patients compared with sham. These findings were accompanied by marked enhancement of rCBV and a higher rate of early recanalization poststimulation in active patients. In 1 active patient with bilateral ischemia of occipital lobes due to bilateral posterior cerebral artery (PCA) occlusions, penumbral salvage, enhancement of rCBV, and early recanalization were only observed on the stimulated side while the contralateral side, serving as an internal control, remained hypoperfused and the vessel remained occluded highly suggestive of a genuine biological effect of stimulation (