Discussion
inflammation, diabetic, T2DM
INFLAMMATION, OBESE, OTHER METABOLIC DISORDERS
Previous studies had already proved that the gut microbiota was a critical environmental factor for treating T2DM and other metabolic disorders (Zhao et al. had revealed that the gut microbiota could bring additional health benefits for patients with T2DM through carbohydrate fermentation and SCFA production (Manipulation of the gut microbiota by prebiotic administration could improve the glucose and lipid metabolism in obese and diabetic mice, and the low-grade inflammation were also decreased (The hippocampal neuronal apoptosis and synaptic structural damage were proved to be associated with the overexpression of proinflammatory cytokines and overactivation of microglia and astrocytes, therefore alterations of intestinal flora could inhibit the immune-inflammatory response and signaling by producing SCFAs (The microbial communities of patients with T2DM were obviously changed after the high-fiber diet administration. The richness and diversity of the bacterial community in the treatment group were both enhanced (