Statistical analysis
In this uncontrolled study, before and after differences between baseline and endpoint values were calculated. The six-month endpoint was the primary endpoint of the study. An alpha threshold of Standardized individual scores from each CBS test (12 individual tests total) were transformed into four domain scores (Concentration, Memory, Reasoning, and Verbal Ability, where each domain represents the composite score of several domain-specific tests from the battery of 12), as well as a single, overall/composite cognition score. These scores were then compared between baseline and the primary endpoint (month six) using paired We then compared our baseline CBS values to the normative means calculated from the CBS data repository (consisting of test results from eight million tests completed globally by more than 75,000 cognitively healthy adults), represented as percentiles [