INTRODUCTION
Chronic constipation, chronic constipation
Chronic constipation is one of the main obstacles to healthy longevity in the world's aging society. A meta-analysis showed that the prevalence of chronic constipation is 10.1% when Rome IV criteria were used, and the incidence increases with age (In recent years, reports using next-generation sequencing have shown that the amount of bifidobacteria is reduced in the stools of elderly individuals (