Change in nirsevimab IC50 for major RSV F protein variants evaluated in the Phase 2b and MELODY trials (full cohort).
Individual major variant substitutions from Phase 2b and MELODY trials were evaluated in a validated RSV neutralization susceptibility assay (Viroclinics Biosciences BV, Rotterdam, NLD) and compared with RSV A and B reference viruses. Both I206M and Q209R were identified in RSV B. Green, yellow and red banding represents a low, medium, and high degree of IC