Study design, population and settings
blunt chest trauma, acute respiratory failure, trauma
ACUTE RESPIRATORY FAILURE
The OptiTHO trial was a randomized, open-label, multicenter trial involving 12 centers over a two-year period, from September 2019 to September 2021 (ClinicalTrials.gov Identifier: NCT03943914). The trial was approved for all centers by the Patients were eligible for study enrollment if they met all of the following criteria: adult patients admitted in intensive care unit (ICU) within 48 h after a high-risk blunt chest trauma, with a thoracic trauma severity score (TTSS) ≥ 8 and an estimated PaORandomization was performed using a secured centralized web-based management system with stratification by center and PaOA preventive strategy, associating HFNC-OThe standard of care associating COT and “late” NIV, indicated in patients with signs of acute respiratory failure and/or with an estimated PaO