Statistical Tests
diplopia, Proptosis, proptosis
DIPLOPIA, PROPTOSIS, PROPTOSIS
A mixed model for repeated measures (MMRM) analysis of covariance model fitting to the individual change from baseline scores for the study eye was used to analyze change from baseline in proptosis and included baseline value, treatment group, visit, visit-by-treatment, and visit-by-baseline value as fixed effects, and patients as a random effect. The change from baseline at Week 24 in GO-QOL overall and subscale scores were analyzed using MMRM. Proptosis responder rate at Week 24 for study eye, diplopia responder rate at Week 24, and complete diplopia responder rate at Week 24 were analyzed using the Fisher exact test. The change from baseline at Week 24 in diplopia as ordinal response categories was analyzed by the proportional odds model (The trial is registered with Clinicaltrial.gov: NCT04583735 (Enrollment closed).