DISCUSSION
ovarian cancer
DISEASE PROGRESSION, OVARIAN CANCER, INFILTRATION, METASTASIS, REGRESSION, METASTASES, PERITONEAL DISSEMINATION
The finding of PC in GC is considered uncurable and the final stage of the disease progression. To date, patients with PC only have palliative therapeutic perspectives, presenting an extremely dismal prognosisIn GC with peritoneal metastases, experimental treatment options such as conversion surgery plus HIPEC and normothermic IPC are currently being investigatedAlthough other anticancer drugs for intraperitoneal administration have been used, such as cisplatin and mitomycin C, PTX appears to be a better alternative for IP administrationDespite the advantages, some limitations of IPC are also described. Among them, the depth of infiltration from the surface of the peritoneal disseminated nodules is limited, and the drugs may not reach the deepest part of a large noduleIn fact, the survival benefits obtained with IPC plus systemic CMT for the peritoneal dissemination of ovarian cancer encouraged its use for peritoneal metastasis of GC. Recently, studies on the intraperitoneal administration of CMT for GC have demonstrated encouraging progressionSome studies reported that IPC is efficient in patients with GC who have peritoneal metastasis and can achieve complete regression of lesions in a significant portion of casesTherefore, conversion therapy combining systematic chemotherapy and IPC, followed by surgical intervention, seems to be a better choice for GC patients with PCTraditional imaging techniques are not sensitive enough for the detection and evaluation of peritoneal metastasis, particularly due to false-negative rates. SL is the gold standard to confirm the diagnosis and extent of peritoneal metastasisTo better clarify this issue, this clinical trial will compare the conventional cytological technique with LBC. LBC was developed with the purpose of seeking greater sensitivity for cytological evaluation than the conventional method. By cytology monolayer liquid, it is possible to obtain a monolayer (or thin layer) cytology, as well as a slide with a cleaner bottom, without overlapping cells and obscuring other elements, due to the filter system that causes only epithelial cells to be retained