2.1. Ethics
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Ethical approval was awarded in Ireland by the Dublin Institute of Technology, Research Ethics Committee (approval ref. 13.103); in Spain by Comité de Ética de La Investigación con Medicamentos del Hospital Universitario de la Princesa, Madrid (Nº de registro: 3221); and in Czechia by the Ethics Committee of the Regional Hospital in Liberic (ref no. EK/22/2018) (The study protocol (also included in the 