4. Discussion
swelling, blood loss, DVT, pain, TKA
BLOOD LOSS, COLD, COMPLICATIONS, DVT
Cryotherapy, also known as cold therapy, as an age-old treatment method on acute soft tissue injury, is gradually applied to TKA postoperative rehabilitation, which is also utilized to enhance recovery and outcomes after TKA.How to further reduce perioperative blood loss of TKA is the point we have been working on. TXA has been well documented in reducing blood loss, whether intravenously, topically, or orally,Perioperative pain and joint swelling of TKA, which have been affecting patients’ satisfaction, were also the primary outcomes of this study. Some studies have proved that cryotherapy can reduce perioperative joint pain, swelling, improve ROM and shorten p-LOS. In an earlier prospective randomized controlled study, Sadoghi et alFor new cryotherapy combined with intra-articular injection of TXA, it is generally believed that the incidence of complications is more concern. In this study, the incidence of DVT in Group A, B, C and D was 1/50, 2/50, 2/50 and 1/50, and there was no significant difference in the incidence of perioperative DVT among the 4 groups (This study had some limitations. Firstly, 3 months of follow-up might have concealed different long-term safety profiles in our study. Secondly, the small sample and single center study may weaken the convincing power of our study. Thirdly, this study cannot confirm whether continuous cold flow device is superior to traditional cryotherapy, which is what we need to work on next. Fourthly, single and small doses of TXA may have attenuated the anti-inflammatory effect, and we may try multiple and large doses for further confirmation. Fifthly, we explored the effect of continue cryotherapy combined with TXA without involving clear temperature and suitable dose of TXA for the best effect, and our further study might perform several studies to explore the effect of different temperatures combined with different doses of TXA.