Discussion
BPD, respiratory distress syndrome
PRETERM BIRTH, RESPIRATORY DISTRESS SYNDROME, COMPLICATIONS
In meta-analyses of randomised controlled trials, surfactant application via LISA is superior to surfactant application via an endotracheal tube in terms of mechanical ventilation within the first 72 h of life, BPD, other complications of preterm birth, and mortality [Important uncertainties persist with regard to the possible benefits of LISA in preterm infants with mild respiratory distress syndrome and FiOProphylactic LISA treatment rates will be 100% in the intervention group of the pro.LISA trial and 0% in the control group. We estimated that within the first 3 days of life, about 50% of control group infants will develop FiO