Background
anxiety, MH, Behavioral impairments, aggression, opioid use disorder, depression, irritability, affective dysregulation
DISORDER, ZINC DEFICIENCY, DYSFUNCTION, DISORDERS
As one of the first-line treatments for opioid use disorder, methadone maintenance treatment (MMT) seems to be a long-acting or permanent therapy that replaces opioids with other safe alternatives to control physical and mental problems facing patients with opioid use disorder [The evidence further suggests that many patients with opioid use disorder undergoing MMT suffer from mental health (MH) problems, including depression and anxiety [A noteworthy achievement in such programs is sustainability. Higher relapse rates in this respect mean that a large number of patients with opioid use disorder discontinue treatment and start drug use; therefore, therapy is not effective [Of note, a healthy, balanced diet containing essential micronutrients supports effective treatment for patients with opioid use disorder undergoing MMT [Behavioral impairments, depression, affective dysregulation, anxiety, aggression, and irritability, as the disorders that are predominantly associated with CNS dysfunction, often occur due to zinc deficiency, as evidenced in human and animal specimens [