Study design
A randomized, parallel double-blinded clinical trial was carried out in accordance with the modified Helsinki’s code for human clinical studies 2013 [This clinical trial received approval from the Research Ethics Committee at the Faculty of Dentistry, Alexandria University (IRB 00010556)-(IORG 0008839), and was registered on ClinicalTrials.gov (NCT05608057) on (01/11/2022). The study protocol was thoroughly explained to each participant, and a written informed consent was obtained.