Author contributions
C.W.T., K.Y.C., H.L.W., C.C.L., and H.S.H. designed the study and prepared the clinical protocol; C.W.T., KYC, HLW, and CCL implemented the clinical trial and were involved in data acquisition; CWT and KYC analyzed and interpreted data; CWT, KYC and HSH drafted and revised the manuscript, KYC, HLW, CCL and HSH contributed to the manuscript. All authors have read and approved the manuscript.