Sample size calculation
TAOS
The power analysis of the study was performed on the primary outcomes TOS and TAOS. To detect a change of 20% between groups with 90% power and α = 0.05, a sample size of 50 patients per group was needed and to account for dropouts 180 patients were recruited. Primary outcomes in this report were TOS and TAOS plasma concentration. Secondary outcomes were periodontal parameters and HbA1c levels.