Authors’ contributions
PD, HL
YW and AJ designed the study with advice from DL. The Statistical Analysis Plan was finalized by YW, PG, and YY prior to unblinding of data. PD, LC1, HW, SH, JL, XF, QQ, HZ, RZ, HL, GX, JY, LC2, SW, WN, and RG contributed to the acquisition of the data. YY and AJ analyzed and verified the data. PG, DL, and PE helped with data analysis and interpretation. YY, AJ, DL, and YW wrote the first draft with all co-authors participating in the subsequent reviews and revisions. YW had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.