Keywords
HNSCC, Head and neck squamous-cell carcinoma
METASTATIC DISEASE
Head and neck squamous-cell carcinoma (HNSCC) is a significant cause of morbidity and mortality worldwide. Approximately 10% of patients with HNSCC have metastatic disease at presentation, 20–30% will develop metastatic disease after definitive treatment and 40–60% will progress within 3 years after curative therapy [