Authors’ contributions
SHK and CSH wrote the first draft of the paper. SHK prepared the figure. SHK, LMT, STC, YS, YCC, HTY, YLK, CCH, TPL, YHL, MT, and CSH have discussed the study design and contents of this protocol in the combined conference of the TBCC and the Japan ARO. SHK, LMT, STC, YS, YCC, HTY, YLK, CCH, TPL, YHL, MT, and CSH were involved in the study protocol and revised the manuscript for the relevant scientific content. TPL was specifically responsible for sample size calculation and description of the statistical analyses. All authors reviewerd and approved the final version of the manuscript.