Pharmacokinetics
While a complete picture of the pharmacokinetic behavior of PEG-liposomal dexamethasone could not be obtained with only limited data from 7 patients, the results shown in Fig. Pharmacokinetic profiles of encapsulated dexamethasone phosphate and free dexamethasone measured simultaneously upon i.v. infusion of two different doses of PEG-liposomal dexamethasoneThe curves also show that with the 40 mg liposomal dexamethasone dose some free dexamethasone enters the circulation upon liposome administration, presumably as a result of liposomal clearance by liver macrophages and lymphoid organs, knowing that the liposomes are stable and are not prematurely leaking drug in the circulation [Pharmacokinetic parameters of liposomal dexamethasone phosphate vs. free dexamethasone at different dosing levels upon i.v. infusion* Indicates free dexamethasone data obtained from literature