2.7. Primary Outcomes
The family of primary outcomes of the main trial includes changes from baseline in oral glucose tolerance, as measured by the glucose incremental area under the curve (iAUC), and the gut microbial beta-diversity, as measured by the weighted UniFrac distance matrix. The weighted UniFrac distance matrix was chosen as it was found to be more accurate [The primary outcome of the Ectopic Fat sub-study is changes from baseline in intrahepatocellular lipid (IHCL), as measured by 