Statistical analysis and data availability
Mann-Whitney U test was used to compare continuous variables between the two groups. Categorical variables were compared using the chi-squared test. Survival rates related to the composite outcomes were calculated using the Kaplan-Meier method and compared using the log-rank test. A linear mixed model was applied to analyze the difference in the pattern of time-dependent change according to the dose of ATG. Time was entered as a categorical fixed-effects variable and the patient identity as a random effect. We first analysed the effect of time on expression of each immune cell separately. Thereafter we constructed a model to look at the effect of the dose of ATG on expression of each immune cell, taking time into account. All covariates for models were chosen For the primary endpoint, it is judged whether the upper limit of the 90% two-sided confidence interval for the difference between the two groups exceeds the non-inferiority margin (10%). In addition, a one-sided Z test for non-inferiority was performed. 