Author contributions
A.J.A.F. developed and led the study, performed data reviews and analyses, and prepared the manuscript. C.R.N. and M.A.O. participated in the data analysis. M.S.M. participated in the manuscript preparation and critical reading of the manuscript. R.L.C. assisted with the NanoString experiments. I.V.V.S. assisted with case selection and sample review. S.C. participated in the manuscript preparation. H.C.S.S. critically reviewed the manuscript. C.P.S. helped with the study design, provided advice during the study development, and critically reviewed the manuscript. M.M.C.M. conceived and guided the development of the study and critically reviewed the manuscript. All authors have substantially revised the manuscript and approved the submitted version.