Conclusions
dysbiosis of the gut microbiota, insomnia, anxiety/depression, anxiety
DISORDERS
In Conclusion, the present study observed that the probiotic JYLP-326 administration could significantly alleviate the anxiety/depression and insomnia symptoms in test anxious college students. The structure and composition of the gut microbiota were altered by the pressure to pass a vital examination with fierce involution, as well as the same to the changes in fecal metabolites. Specifically, JYLP-326 treatment protected against this exam stress-induced dysbiosis of the gut microbiota and the disturbances of fecal metabolomic. Furthermore, the changed gut microbiota genera and fecal metabolites were closely associated with stress-related symptoms like anxiety/depression and insomnia, indicating they might be regarded as biomarkers for diagnosing and treating stress and anxiety disorders.