3. Results
VF
A total of 704 children were enrolled in the study with a median age 9 years (interquartile range (IQR) 7, 12); 344 (49%) were female, and the median time on ART was 5 years (IQR 3, 8). A total of 349 (49.5%) and 355 (50.5%) of the CHIV were randomized to the intervention and control groups, respectively. Overall, 382 (54.3%) of the participants were on an NNRTI-containing regimen at study enrollment, 294 (41.8%) were on a PI-containing regimen, 27 (3.8%) were on an INSTI-containing regimen, and 1 (0.1%) was on a PI and INSTI regimen (During the 12-month study period, 190 study DRTs were requested for 106 (15%) participants across the two study groups. Among the intervention participants, 88 (25%) children experienced at least one episode of VF, and all had a least one DRT requested for a total of 166 DRT requests, and 152 (92%) had results. (Of the total 190 DRTs requested by the study, 16 (9%) total samples from 16 participants did not yield a result, with 14 (87%) samples failing to amplify and 2 (13%) having insufficient volume to be tested. Fourteen participants in the intervention group had a “failed” result, of whom ten (71%) had a successful subsequent repeat DRT. An additional three (21%) intervention participants re-suppressed to VL < 1000/mL and had no further indication for DR testing. Two children in the control group who had DRT performed at 12-month visit per protocol that failed to amplify were referred for repeat of DRT by facility staff via routine care.