Ethics approval and consent to participate
The study is approved by the Institutional Review Board (IRB) of Weill Cornell Medicine (IRB #: 20–03021572 – SHORTER Trial). The IRB-approved protocol and study data are reviewed by the Weill Cornell Medicine Data and Safety Monitoring Board (DSMB). All methods in this study are carried out in accordance with relevant guidelines and regulations, including the Weill Cornell Medicine Data and Safety Monitoring Plan (DSMP) and the Declaration of Helsinki. Informed consent was obtained from all participants and/or their legal guardians. Patients’ eligibility on the trial were reviewed and signed off by the treating physicians. Consented and eligibility verified patients were enrolled on the Weill Cornell Medicine Clinical Trial Management System (CTMS).