References
Myocardial damage
WASTED, HEART, HEART FAILURE, BREAST CANCER
Protocol scheme. GLS—global longitudinal strain; HR—heart rate; LVEF—left ventricular ejection fraction; MW—myocardial work; NT-proBNP—N-terminal natriuretic pro-peptide; RV—right ventricle; Tn I—troponin I.Clinical trial diagram.Heart rate achievement during the study in ivabradine group patients. AC—anthracyclines; BPM—beats per minute; HR—heart rate.Changes of global longitudinal strain in study groups during the study period. GLS—global longitudinal strain. *—statistically significant difference compared to baseline (Levels of troponin I during the study period. Tn I—troponin I; *—statistically significant difference compared to baseline (Changes of left ventricular ejection fraction. 2D—two-dimensional; 3D—three-dimensional; LVEF—left ventricular ejection fraction; *—statistically significant difference compared to baseline (Measurements of right ventricle tricuspid annular systolic velocity during the study period. RV—right ventricle; S’—tricuspid annular systolic velocity by tissue Doppler; *—statistically significant difference compared to baseline (Change in global myocardial constructive work and global myocardial work index. GCW—global constructive work; GWI—global work index; *—statistically significant difference compared to baseline (Myocardial damage markers. GLS—global longitudinal strain; LVEF—left ventricular ejection fraction; NT-proBNP—N-terminal pro-brain natriuretic peptide; Tn I—troponin I.The baseline characteristics of the patients.2D—two-dimensional; 3D—three-dimensional; BMI—body mass index; BRCA—breast cancer gene 1; DT—deceleration time; GCW—global constructive work; GFR—glomerular filtration rate; GLS—global longitudinal strain; GWE—global work efficiency; GWI—global work index; GWW—global wasted work; Hb—haemoglobin; HER2—human epidermal growth factor receptor 2; HF—heart failure; CRP—C-reactive protein; IVRT—isovolumic relaxation time; LAVI—left atrial volume index; LV—left ventricle; LVEF—left ventricular ejection fraction; NT-proBNP—N-terminal natriuretic pro-peptide; RV—right ventricle; RV S’—tricuspid annular systolic velocity by tissue Doppler; SD—standard deviation; TAPSE—tricuspid annular plane systolic excursion; Tn I—troponin I. * 3D echocardiography was performed in 32 patients (14 in ivabradine and 18 in the control group).Changes in echocardiographic parameters between groups.2D—two-dimensional; 3D—three-dimensional; GCW—global constructive work; GFR—glomerular filtration rate; GLS—global longitudinal strain; GWE—global work efficiency; GWI—global work index; GWW—global wasted work; LVEF—left ventricular ejection fraction; RV—right ventricle; RV S’—tricuspid annular systolic velocity by tissue Doppler; SD—standard deviation; TAPSE—tricuspid annular plane systolic excursion; *—statistically significant difference compared to baseline (Changes in cardiac biomarkers.AC—anthracyclines; NT-proBNP—N-terminal pro-brain natriuretic peptide, Tn I—troponin I. *—statistically significant difference compared to baseline (