Subgroup analysis
Anxiety, anxiety, SE, depression, Depression
GROUP B
We performed subgroup analyses with persons with high and low baseline levels of anxiety or depression. The sample size of the subgroup analysis (high baseline anxiety levels: n = 77) is sufficient to detect the minimum clinically important difference of 1.5 points on the HADS (baseline standard deviation of 3 points) with a t-test, assuming a two-sided error probability of 5% and to achieve a power of 58%.At the end of rehabilitation, patients in group A with high baseline levels of anxiety had 2 points less on the depression scale compared to patients in group B with high baseline levels of anxiety (HADS depression: difference = -1.9; 95% CI -3.5 to -0.3; p = 0.019) (Table 
Anxiety and depression in subgroups of different levels of anxiety or depression at baselineHigh anxiety (≥ 10)Low anxiety (< 10)36449.1 (0.5)5.5 (0.5)413910.1 (0.5)5.3 (0.5)-1.00.2-2.4; 0.5-1.2; 1.60.1830.782High anxiety (≥ 10)Low anxiety (< 10)36448.9 (0.7)6.4 (0.5)41399.3 (0.6)6.0 (0.6)-0.40.5-2.1; 1.4-1.2; 2.10.6700.577High depression (≥ 7)Low depression (< 7)43378.6 (0.5)5.4 (0.5)49319.6 (0.5)4.8 (0.6)-1.00.5-2.3; 0.4-1.1; 2.10.1610.513High depression (≥ 7)Low depression (< 7)43378.8 (0.6)6.1 (0.6)49319.2 (0.5)5.2 (0.6)-0.40.9-2.0; 1.2-0.8; 2.60.5900.300High anxiety (≥ 10)Low anxiety (< 10)36446.4 (0.6)4.9 (0.5)41398.3 (0.6)4.5 (0.6)-1.90.3-3.5; -0.3-1.2; 1.9
0.671High anxiety (≥ 10)Low anxiety (< 10)36446.8 (0.7)5.7 (0.6)41397.8 (0.6)4.8 (0.6)-1.00.9-2.8; 0.9-0.7; 2.60.3060.266High depression (≥ 7)Low depression (< 7)43377.3 (0.5)3.5 (0.5)49318.5 (0.4)3.2 (0.6)-1.20.3-2.5; 0.1-1.2; 1.80.0590.689High depression (≥ 7)Low depression (< 7)43377.9 (0.6)4.3 (0.6)49317.9 (0.5)3.8 (0.6)0.00.5-1.6; 1.5-1.2; 2.20.9980.590Abbreviations: Group A = structured short-term psychotherapy, Group B = non-specific group discussion, SE = standard error, HADS = Hospital Depression and Anxiety ScaleIn total, 53 participants (IG: n = 26; CG: n = 27) completed their questionnaire at the three-month follow-up after the German Bundestag declared an epidemic situation of national concern due to SARS-CoV-2 by the end of March 2020. In two supplemental models explaining three-month anxiety and depression, we found no evidence of relevant higher impairment in anxiety or depression for patients completing their three-month follow-up questionnaires after the pandemic started to affect Germany.