C-DEPTH.
’s polysymptomatic, anxiety, treatment-induced reduction, MDD, depression
REMISSION
Medial and lateral stimulation are expected to differently affect brain activity. Therefore, while both treatments were found to be similar in their overall effectiveness across all measures, the 2 stimulation sites may differentially treat distinct populations with MDD. To explore this, we analyzed the relation between baseline (pretreatment) symptom cluster severity and response to 1 H-coil (brain target) over the other. Informed by recent evidence of the H1 coil’s polysymptomatic effect on depression and anxiety symptoms (Baseline C-DEPTH scores were significantly and positively correlated with treatment-induced reduction in HDRS-21 scores following treatment with the H1 coil (By splitting the predictive cluster into depression and anxiety, we observed that this prediction was primarily driven by the anxiety subcluster for the H1 coil and tended to be driven by the depression subcluster for the H7 coil (see While the C-DEPTH threshold was constructed for the prediction of response rates for the different H-coils, it also revealed a trend for predicting remission rates. Patients with C-DEPTH > 0.5 had remission rates of 58% following treatment with the H1 coil and only 33% following treatment with the H7 coil (χIn an attempt to validate C-DEPTH ability to predict response to the H1 coil (no corresponding database is available for the H7 coil, which makes a true validation impossible), we tested outcomes of an independent data set collected under similar conditions (