Funding
Funding was obtained from Helsinki University Hospital research funds (J.S.T. and A.H.), the Hospital District of Helsinki and Uusimaa (K.L., T.T. and O.H.), the Sigrid Juselius Foundation (J.S.T. and T.T.P.), the Academy of Finland (J.S.T. and T.T.P. 315921 and 321763), the Finnish Medical Association (M.H.K., A.H. and T.T.P.), the University of Oulu Graduate School (M.H.K.), the Emil Aaltonen Foundation (M.H.K.), the Swedish Cultural Foundation in Finland (A.H.), the Novo Nordisk Foundation (R.K.A.), Orion Research Foundation (A.H.) and the Northern Ostrobothnia Regional Fund (R.K.A.). The funders had no role in study design, data collection and analysis, publishing decisions or manuscript preparation.