Plasmid manufacture
All clinical products were manufactured in the PACT Plasmid and Cell GMP manufacturing facilities (South San Francisco, CA) following clinical manufacturing protocols. neoTCR-P1 plasmid was propagated from patient-specific HR template plasmid generated for TCR validation, using selected patient-specific HR template plasmid as source material for GMP plasmid manufacturing. Patient-specific plasmid reagent was transformed into 