Placebo group analysis
LME
To control the effectiveness of the paradigm, we verified trace fear acquisition and retention within the placebo group. Averaged across the entire acquisition session, we found CS+/CS− differentiation for SCR to CS presentation (CS+/CS− differences in skin conductance responses (SCR) and pupil size responses (PSR) during acquisition training. CS+/CS− differences in startle-eye blink responses (SEBR) and skin conductance responses (SCR) during recall visit 3 and their correlation with doxycycline level in serum. Relation of doxycycline levels with SEBRANOVA for the relation of doxycycline levels with SEBR, dependent on condition and trial number, only for the doxycycline group. Significant effects are marked with ‘*’.Extinction paired t test CS+/CS−, not corrected for multiple comparisons. Download Extinction independent t test between CS+/CS− difference for placebo and doxycycline group, not corrected for multiple comparisons. P = Placebo, D = Doxycycline Download Extinction paired t test CS+/CS− per gender, not corrected for multiple comparisons. Download Extinction independent t test between CS+/CS− difference for placebo and doxycycline group per gender, not corrected for multiple comparisons. P = Placebo, D = Doxycycline Download SEBR ANOVA in fear recall. Download SEBR LME in fear recall. Download SCR and doxycycline level (in doxycycline group) LME in fear recall. Download 