Consensus phenotype predictions
We established a procedure to reconcile inconsistent phenotype predictions between the three strategies described above, based on observing discordant gene patterns and/or discordant predicted phenotypes within a given group of neighbour genomes. In the rare case of an irreconcilable disagreement between the prediction methods, assignment of a consensus phenotype defaulted to that produced by the machine-learning method. We assigned consensus confidence scores to each prediction on the basis of the degree of concordance between the three techniques and our confidence in the accuracy of each (