Introduction
chronic cough, asthma, RCC, cough
ALLERGIC RHINITIS, ASSOCIATED CONDITIONS, ASTHMA, GASTROESOPHAGEAL REFLUX DISEASE, RCC
Patients with chronic cough (cough persisting > 8 weeks) experience considerable burden to health-related quality of life. While chronic cough associated with underlying conditions (e.g., asthma, allergic rhinitis, or gastroesophageal reflux disease) can be successfully treated in some patients, it persists in many patients despite treatment for those underlying conditions (refractory cough; RCC). For other patients, no associated condition is identified despite thorough workup (unexplained chronic cough; UCC). For both groups of patients, there are no licensed treatments, which represents a considerable unmet medical need.Gefapixant is a P2X3 receptor antagonist with recently confirmed efficacy in two large phase 3 randomized, controlled clinical trials of participants with RCC or UCC who had suffered from chronic cough for many years [