The oral microbiome is genetically more dynamic than the gut microbiome
EVENT
Our study is unique in having both oral and gut microbiome samples before and after dietary interventions. Our results show that the gut microbiome experienced greater change at the compositional level compared to the oral microbiome. To further investigate the difference between the environments, we assessed the genetic level of microbial strains, as two strains of the same species can differ in their genetic makeup by up to 5%We defined a strain replacement event for each species based on the genetic similarity between the pre- and post- intervention samples. This measurement could be aggregated at the participant level, indicating the percentage of species replaced in each individual, or at the species level, indicating the percentage of individuals who had a particular species replaced (out of those who had it). We did not find a statistically significant difference between the diets in the gut nor the oral environments (