ACKNOWLEDGMENTS
We wish to thank all of the patients together with their families for participating in this study, as well as the investigators and staff at each study site for their contributions. We also thank Yuki Fukuyama of Ono Pharmaceutical Co., Ltd., Osaka, Japan, for providing essential statistical support. The authors thank Nicholas D. Smith (EMC K.K.) for providing medical writing support, which was funded by Ono Pharmaceutical Co., Ltd.