Multivariable Analysis of Cancer Risk by Change in BMI 
GI, gastrointestinal; HR, CRC, cancer, GI cancer, overweight or obese BMI, overweight, diabetes
COLORECTAL CANCER, OBESE, MYOCARDIAL INFARCTION, STROKE, CANCER, GI CANCER, HYPERTENSION, DIABETES
Abbreviations: BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); CRC, colorectal cancer; GI, gastrointestinal; HR, hazard ratio; NA, not applicable.The model was adjusted for age at randomization, randomization arm, center, sex, race, smoking status, aspirin use, ibuprofen use, and history of myocardial infarction, stroke, hypertension, or diabetes.Finally, because of the potential influence of overweight or obese BMI on cancer preventive agent efficacy, we wanted to evaluate the association between BMI and CRC and noncolorectal GI cancer risk among frequent aspirin users. Among frequent aspirin users, overweight or obese BMI in early (HR, 1.44; 95% CI, 1.23-1.68; 