T cell reconstitution
SECONDARY
As a secondary endpoint, T cell reconstitution was compared between the two groups at equivalent time points, starting before the first infusion of the T cell product. An example of flow cytometric analysis of peripheral blood is shown in T cell reconstitution during study treatment. Patients (n=9) randomized into treatment group (red line) were analyzed at the time of the visit before the T cell transfer (24-48h, visits 2, 8, and 12). Patients in the control arm (n=13, black line) were analyzed at study visits aligned as possible with the treatment group at day 30 ± 3 (visit 2), 60 ± 3 (visit 8), 90 ± 3 (visit 8), and at the end of study at approximately day 204 ± 7 (visit 17). The graph shows average numbers of CD4+ 
Reconstitution of CMV/EBV specific T cell immunity in treated individuals. Left Panel: Reconstitution of CMV- and EBV-specific T cells during the study observation period. Red lines indicate the sum of all CMV specific in the peripheral blood (cells/ul), yellow lines the sum of all EBV-specific CD8+ T cells detected by using peptide-loaded HLA class I multimers according to the HLA class I loci present in the patient on the top right of each graph. Black arrows indicate the transfusion of the IMP. Red and yellow horizontal bars indicate the presence of CMV and EBV respectively as assessed by PCR in the peripheral blood. Right Panel shows the overall reconstitution (number of cells/ul peripheral blood) of CD4+ (light blue line) and CD8+ (dark blue line) T cells in each individual patient.