Results
±, allergy
BLOOD, ALLERGY

Baseline demographic characteristics of all patients who completed the 3-year Follow-Up given as mean with standard deviation or absolute (relative) frequency. Longer cut-sew time in allergy group due to suture instead of stapling. p-values: While the non-allergy groups were not different regarding pre- and perioperative data, such as gender, age, body mass index (BMI), surgery time and co-morbidities we found the allergy patients to be significantly younger. Moreover, the gender was not distributed equally in this group since all allergy patients were female. Also, the cut-sew time in this group was significantly longer. In order to address this issue and allow for comparability we established a matched-pair analysis (Table The blood cytokine patterns prior to surgery, one and three years after TKA demonstrated for most parameters no differences between the non-allergy groups (Table 
Blood cytokine levels in Standard and Coated TKA (quantitative values given in pg/ml as median (quartiles), absolute (n) and relative (%) frequencies of values above 0.01 pg/ml). p-values: In contrast to these findings, we observed no elevated IL-6 levels prior to surgery within the allergy group. This is significant compared to the non-allergy groups (p = 0.022). Within the matched-pair analysis, however, this was not evident. All allergy patients presented with measurable levels of IFN γ prior to surgery (p = < 0.001). IFN γ levels dropped at the 1year FU but were still significantly higher compared to the standard, coated and matched-pair group. Similarly, to the non-allergy cohorts IFN γ was not detectable at the 3year FU anymore. The further cytokines displayed no differences between the groups.
PROMs of patients given as mean with standard deviation. p-values: Within the non-allergy groups, we found no relevant differences in PROMs and ROM at any FU (Table Compared to these groups we observed a slower improvement within the allergy cohort. At the 1year FU the patient-reported scores in the allergy group were lower compared to the non-allergy groups. Yet these lower results were not significant.Satisfaction was high in all groups, with a mean of 8.3 (± 2.0) in coated, 8.5 (± 1.7) in standard, 8.3 (± 1.5) in the allergy and 8.1 ± 2.7 in the matched-pair cohort.