Introduction
postoperative adverse reaction, postoperative pain, nausea and vomiting, constipation, dizziness, skin itching, trauma
RESPIRATORY DEPRESSION, INFLAMMATORY RESPONSE
Gynecological laparoscopic surgery has become the main surgical method of gynecological surgery for its advantages of small trauma, light stimulation to patients and short recovery time. Although generally, laparoscopic technique is less painful than the open one, there are still about 20%-40% of patients have moderate or even severe postoperative pain after laparoscopic surgeies [Opioid is the most commonly used intravenous analgesic, but it can lead to opioid-related side effects such as nausea and vomiting, dizziness, respiratory depression, skin itching, constipation. Serious problems caused by the abuse and misuse of opioid have attracted the attention of international scholars [ERAS, which was first proposed by Danish surgeon in 1997, is an evidence-based perioperative optimized measure that can reduce surgical stress and inflammatory response, promote rapid postoperative recovery, and improve perioperative safety and comfort by surgeons, nurses, anesthetists and other relevant medical staffs [Dexmedetomidine is alpha-2 receptors agonist commonly used with its well sedative effect, and esketamine, an N-Methyl-D-Aspartate (NMDA) receptors antagonist, plays excellent analgesic role in clinic anesthesia. They are both non-opioid drugs. In this study, under ERAS protocol in perioperative period, OFA technique, which contained esketamine and dexmedetomidine, was used in gynecological laparoscopic surgery. This is a non-inferiority randomized controlled trial aiming to compare the OFA and OA technique on the effect of analgesia and sedation, postoperative adverse reaction and postoperative sleep quality among gynecological surgical patients under ERAS protocol. Our results may provide clinical evidence for using OFA technique in the future.