Statistical analysis
ONYCHOMYCOSIS
Sample size calculation was based on detecting differences of more than 10 points between groups in the primary outcome (Onychomycosis Severity Index, OSI), assuming standard deviation of 6, error of 0.05 and power of 90% [To check assumptions of normality for the tested variables (OSI, degree of improvement, % of involvement, mycological cure rate and patients’ satisfaction), Shapiro–Wilk test was used. A two-factor [time (within-subject factor) and treatment (between-subject factor)] repeated measures ANOVA was used with the post hoc Bonferroni correction for multiple comparisons. SPSS software for Windows (version 25; SPSS, Chicago, III) was used for the statistical evaluation of the results. A 