MRI response
DISEASE, METASTASES
Disease response on whole-body DWI, defined as a 30% increase in global median apparent diffusion coefficient, was seen in 14 of 36 patients (39%, 95% CI = 23% to 56%, 90% CI = 25% to 54%). For 5 of these patients, response was observed after the first cycle of treatment. Based on a 30% increase in the mean apparent diffusion coefficient of 5 target lesions, response was seen in 23 of 36 patients (64%, 95% CI = 46% to 79%; 90% CI = 49% to 77%). There was marked heterogeneity of response, both between different patients and between different metastases within the same patient (Per-lesion percentage change in mean apparent diffusion coefficient from baseline (0) to cycle 6 of radium-223. Each graph represents data for an individual patient. Each 