Author contributions
S.E.B., A.B., J.S.P., R.H., and H.B.J. designed the microbiota sub-study to the ECHO Trial. B.P.B., C.F., R.F.T., S.Z.J., R.B., S.D., D.D.N., C.F., M.G., and A.H. performed the experiments. M.O., G.N., T.P.P., C.W.S., and H.K. provided logistical support, data management and oversaw all data collection. B.P.B. wrote the first draft of the manuscript. All authors reviewed and approved the final manuscript.