Retrospective sequence analysis after dosing and screening samples
TCRβ, tumour
TUMOUR
Amplicon sequencing-based TCR assays were conducted at Personalis to further interrogate the immune repertoire in tumour biopsy samples and the CDR3 reads. The frequency from TCRα and TCRβ were reported to evaluate the neoTCR trafficking after dosingHLA LOH was analysed using both WES and RNA-seq dataSomatic variants from WES data were used for a custom ctDNA assay made by Natera as previously described