Discussion
WMLs
BLOOD
Intensive SBP treatment was associated with reduced progression of WMLs in the anterior and posterior corona radiata, tapetum, superior fronto-occipital fasciculus, and the corpus callosum in this post hoc substudy of the SPRINT MIND clinical trial. Further analyses indicated a slower decrease in FA, a slower increase in MD, and an improvement in CBF associated with intensive treatment. Overall, our results were consistent with prior findings in other studies. Reduction of WML progression due to BP treatment has been reported previously in the INFINITY (Intensive Versus Standard Ambulatory Blood Pressure Lowering to Prevent Functional Decline In the Elderly) trial,