Handling of missing data
SECONDARY
A completeness index will be used to calculate the completeness of primary survival data [For the remaining secondary effectiveness outcomes, the number of missing observations will be reported at each relevant timepoint (i.e. months 3, 6, 9 and 12). In cases where more than 10% of the outcome data is missing, multiple imputations will be used to conduct sensitivity analyses. The need to impute will be confirmed at the time of the masked review of the data.