Demographics
obesity, heart disease, SD, asthma, hypertension
OBESITY, HEART DISEASE, TYPE 1 DIABETES, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ASTHMA, HYPERTENSION
In the cross-sectional study, 152 participants completed the PRO measures from November 17, 2020, to January 4, 2021 (mean ± standard deviation [SD] age, 51.0 ± 18.6 years [range, 18–90 years]; female, 62.5%; Table 
Participant Characteristics at Screening (Cross-sectional Study)SD, standard deviation; GED, General Educational DevelopmentTwenty of the 152 participants who completed the SIC also completed follow-up interviews from January 7 to February 17, 2021 (mean ± SD age, 51.5 ± 16.8 years [range, 22–73 years]; female, 65%). Interview participants were racially diverse, with 45.0% African American, 25.0% White, 5.0% American Indian, 10.0% mixed race, and 15.0% other race, and had a range of educational levels, employment statuses, and types of health insurance coverage. Approximately half of the exit interview participants (45.0%; 9/20) had a preexisting risk factor increasing the likelihood of severe COVID-19 outcomes. Preexisting conditions included asthma (45.0%), obesity (35.0%), hypertension (35.0%), heart disease (25.0%), chronic obstructive pulmonary disease (10.0%), and type 1 diabetes (5.0%); some participants reported > 1 condition. COVID-19 was reported as severe in 45.0%, moderate in 35.0%, and mild in 20.0% of interview participants, and 45.0% (9/20) had been hospitalized for COVID-19; of those, 4 had received oxygen and 2 were admitted to the intensive care unit.From ENSEMBLE2 (November 16, 2020, to June 25, 2021), 183 participants with confirmed moderate to severe/critical COVID-19 occurring from Days 15 to 56 post–primary vaccination, but before planned booster vaccination, were included in this analysis (mean ± SD age, 51.5 ± 14.8 years [range, 18–85]; female, 43.7%). Participants were 65.0% White, 18.0% Asian, 13.7% American Indian or Alaska Native, and 2.7% Black. Participants came from Europe (32.2%), the United States (27.9%), Latin America (23.0%), the Philippines (13.1%), and South Africa (3.8%). Of these 183 participants, 130 completed the SIC.