Introduction
dengue, heterotopic DENV infections
DENGUE
The four dengue viruses (DENV 1-4) transmitted by the With dengue declared as one of the top ten threats to global health,Studies in murine models suggest that CD8+ T cells are essential for protection against heterotopic DENV infections and potentially reduce the risk of ADE.PepGNP-Dengue is a candidate vaccine that has been designed to elicit a specific cytotoxic CD8+ T cell response, without inducing a humoral one. It is composed of synthetic T cell-selective multi-valent DENV peptides carried on ultrasmall gold nanoparticles (GNPs), chosen for their immunogenic properties,The safety and immunogenicity of PepGNP-Dengue have been demonstrated in preclinical 