Summary/Conclusions
anogenital malignancies, HPV-associated cancers
DISEASE
We demonstrate prolonged disease control using combination immunotherapy with a therapeutic HPV-16/HPV-18 DNA vaccine and IL-12 adjuvant in some patients with advanced HPV-associated anogenital malignancies. A minority of patients with HPV-associated cancers experienced durable clinical benefit with durvalumab and MEDI0457 that exceeded 1 year.