Cost-Effectiveness
The primary measure in the cost-effectiveness analysis was the incremental cost-effectiveness ratio (ICER), calculated by comparing the mean cost difference between intervention and control groups to the mean effectiveness difference, based on changes in ADAS-Cog-Plus after the 6-month exercise intervention. Although no established minimally clinically important difference (MCID) exists for the ADAS-Cog-Plus, an MCID of 3 points for the 13-item ADAS-Cog in recommended.