Discussions
TB, confusion, fatigue, drowsiness, vomiting, constipation, hypercalcemia, infection, TB infection, polydipsia, necrosis, polyuria, hypercalciuria, apathy
RECURRENCE, SIDE EFFECT, PROLIFERATION, TUBERCULOSIS INFECTION, HYPERCALCEMIA, INFECTION, VITAMIN D DEFICIENCY, NECROSIS
All groups experienced increased vitamin D levels at both week 4 and week 8. The 10,000 IU dose group saw the highest increase in vitamin D during 8 weeks of supplementation, from 27.91 ± 8.68 ng/ml to 66.40 ± 4.89 ng/mL. Supplementation of vitamin D 10,000 IU/day for 8 weeks can increase vitamin D levels > 50 ng/dl so that it functions optimally as an immunomodulator. Meanwhile, at other doses it did not reach > 50 ng/ml.A study conducted by Nurpudji et al. [Vitamin D deficiency has always been associated with an increased risk of infection with A study by Gibney et al. [Vitamin D supplementation at doses of 400, 5000, and 10,000 mg/dl for 8 weeks may also affect TLR 2 and TLR 4 levels. There was a difference between TLR 2 and TLR-4 levels of 7 mg/dl to 15 mg/dL at week 8 compared to week 0. The study also found a significant correlation between vitamin D levels for TLR-2 and TLR-4. After supplementation, TLR-2 and TLR-4 levels increased. This increase in TLR indicates an increased immune response that plays a role in the process of fighting The concentration of vitamin DCharacteristics of the subjectsSimultaneous activation of the TLR2 and TLR4 signaling pathways induces macrophage apoptosis and induction of apoptosis and necrosis in response to In a study conducted by Ali et al. on TLR-2 levels in cases of tuberculosis infection, significant differences in serum TLR2 levels were found in each variation of TB infection cases. In cases of recurrence of tuberculosis infection, TLR-2 serum levels were found to decrease significantly compared to new cases of TB infection [Other studies showed similar results, as Rahmini Shabariah et al. showed a significant increase in serum levels of TLR-2 and TLR-4 in patients with extrapulmonary TB who had post-vaccination scars of Vitamin D has functions in the immune system, cell proliferation, and differentiation. Supplementation of vitamin D to > 100 nmol/L shows an increase in TLR-2 expression and a decrease in the TLR2-profile of cytokine stimulation for TNF, IL-6, and IFN, and this condition will be reversed when vitamin D doses are reduced to < 100 nmol/L (The side effect of supplementation with vitamin D is intoxication. It is characterized by markedly elevated vitamin D concentrations (usually > 150 ng/ml), hypercalcemia, hypercalciuria and PTH suppression. Clinical manifestations are associated with hypercalcemia and include: weakness, fatigue, confusion, drowsiness, apathy, vomiting, constipation, polyuria, polydipsia, and abnormalities on the electrocardiogram (reduced Q-T interval) [