Background
death, diabetic foot ulcer, CVD, diabetic cardiovascular complications, atherosclerosis
DIABETIC FOOT ULCER, CARDIOVASCULAR DISEASE, CVD, ARTERIAL STIFFNESS, MACROANGIOPATHIES, ATHEROSCLEROSIS
Cardiovascular disease (CVD) is the leading cause of death worldwide [Advanced glycation end products (AGEs) have recently emerged as a novel actionable marker for diabetic cardiovascular complications [A higher SAF level predicts independently diabetic foot ulcer that is closely linked to micro and macroangiopathies [To understand the role of AGEs in the development of CVD, this study assessed how and through which subclinical cardiovascular changes skin AGEs are related to CVD in the general population and investigated potential subgroup differences in these associations. The associations of SAF with multiple endophenotypes in different vascular beds, reflecting atherosclerosis or arterial stiffness, were investigated in the well-characterized population-based Rotterdam Study after confirming an association of SAF with CVD.