Maximum well-tolerated opioid reduction
SD
Across the 20 participants, the average successful dose reduction was 12.3 MME (SD 11.4, Range 0–37), from 39.0 to 26.8 MME (Fig. Opioid dose reduction. With these reductions in opioid dose, many participants crossed previously defined risk thresholds. The CDC has recommended a risk threshold of 50 MME daily opioid dose [