Pharmacokinetics
HL-085 exposure (area under the curve and maximum plasma concentration) is close to dose proportional over the dose range of 0.5–15 mg twice daily with minimal accumulation. The mean plasma terminal half-life is 21.84 h–34.41 h. More detailed results of the pharmacokinetic analysis of the parent study are described in another article which was recently published by Qian Zhao et al. [