Site practice after cessation of pharmacological treatment for NOWS
Seventeen ISPCTN and NRN sites submitted guidelines and protocols they use to treat infants with NOWS (morphine use: 12 sites, methadone use: 5 sites). In eight of the 17 guidelines, there were specific directives that clinical teams should monitor NOWS infants receiving pharmacological therapy in the hospital for at least 48 h after treatment cessation. In the other nine guidelines, there were no comments on the duration of observation after pharmacological treatment cessation.