Heterogeneity in treatment effects
respiratory failure
ISCHEMIC HEART DISEASE, RESPIRATORY FAILURE, DIABETES MELLITUS, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, HEART FAILURE
We assessed HTE using frequentist analyses without adjustment according to the following four baseline characteristics:Age (years)Weight (kg)Category of respiratory failure on a 1–6‐point scale defined as follows:Open system, low oxygen flow (oxygen flow rate ≤ median oxygen flow rate in all patients on open systems).Open system, high oxygen flow (oxygen flow rate > median oxygen flow rate).NIV/CPAP, low fraction of inspired oxygen (FiONIV/CPAP, high FiOInvasive mechanical ventilation, low FiOInvasive mechanical ventilation, high FiONumber of comorbidities (diabetes mellitus, ischemic heart disease or heart failure, chronic obstructive pulmonary disease or immunosuppression within 3 months prior to randomisation) on a 1–4‐point scale with patients with three or four comorbidities analysed in the same category as only one patient had all four comorbidities.In addition, we assessed HTE according to the baseline predicted risk of 90‐day mortality using an internal prediction model developed in the control group (6 mg) as described below.