Conclusion
encephalitis
ENCEPHALITIS, RECRUITMENT
The IgNiTE study was terminated prematurely due to slow recruitment and therefore did not reach the predetermined sample size required to evaluate the effect of IVIG compared with placebo in childhood encephalitis. However, the study results support existing evidence of poor neurological outcomes in many children with encephalitis. This provides further compelling evidence of the need for better treatments in childhood encephalitis. Future studies are required to establish if treatment with IVIG is of benefit in children with encephalitis of all causes. Such studies should take into account the challenges encountered and lessons learnt from the IgNiTE study.