Conclusion
CHRONIC PAIN
To our knowledge, this is the only laboratory study to examine the independent and combined effects of doses of dronabinol (10 mg) and hydromorphone (4 mg) that are within the range that can be prescribed therapeutically on a comprehensive array of clinically-relevant outcomes in individuals with chronic pain. These data extend our prior research with healthy adults by providing further evidence that combining dronabinol with hydromorphone for analgesia and physical function yields little benefit in a clinical cohort. The doses tested for dronabinol did not improve hydromorphone’s analgesic profile but did increase ratings of High, as well as negative side effects, and AEs. Finally, any significant analgesic effect observed following dronabinol + hydromorphone appeared to be driven by the hydromorphone, negating dronabinol enhancement of analgesia at the dose tested.