Strengths and limitations
obesity, FM
OBESITY, SECONDARY
Although the sample size was adequate for the primary outcomes, the subgroups in our secondary analysis were small, diminishing statistical reliability. The patient and control groups were not entirely homogeneous regarding their anthropometrics, educational and employment status. This reflects real-life differences between patients with FM and their same-aged peers. Although obesity has a multitude of systemic effects, adipose tissue does not affect oxygen uptake during exercise, and The main strength of this study lies in the simultaneous recording of ventilatory gas exchange and ICG data. To the best of our knowledge, exercise responses in patients with FM have not been studied this intensively before.