Endpoints
death, Cancer
RECURRENCE, ADVERSE EVENTS, SECONDARY, SURGICAL COMPLICATIONS, CANCER
The primary endpoint was 3-year DFS, defined as the time from the date of the operation to the earliest date of recurrence.The secondary endpoint was OS, defined as the time from the date of the operation to the date of death due to all causes or the date of the last follow-up, chemotherapy-related adverse events according to CTCAE 4.0, surgical complications during chemotherapy according to the Clavien–Dindo classification, and quality of Life (QoL) assessment according to the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ) C30. The patients completed baseline questionnaires after providing consent and before initiating AC. When patients visited the outpatient clinic, follow-up questionnaires were administered to patients 1, 3, 6, and 12 months after surgery.The review of case report forms was conducted annually for quality control by the Kyungpook National University Cancer Centre (Daegu, Korea).