Introduction
vascular dysfunction, tachycardia, seizures, eclampsia, Preeclampsia, multi-system disorder, visual disturbances, headache, cerebral edema, cerebral injuries, preeclampsia
DISORDER, SEVERE PREECLAMPSIA, PREECLAMPSIA, ECLAMPSIA, CEREBRAL EDEMA, PREECLAMPSIA
Preeclampsia is a multi-system disorder of pregnancy characterized by widespread vascular dysfunction. One of the most prominent organs to be affected is the brain. Indeed, central nervous system (CNS) manifestations such as headache, visual disturbances, alterations in consciousness, and seizures are considered severe features of the disorder and significantly contribute to maternal morbidity and mortality [Magnesium sulfate (MgSO4) has been used for seizures prevention in severe preeclampsia for many years with demonstrated efficacy in eclampsia prevention and treatment [Labetalol is a nonselective, competitive β-adrenergic blocker and a selective, competitive α1-adrenergic blocker (ratio of blockade 7:1 respectively). It produces a rapid dose-dependent decrease in blood pressure without causing reflex tachycardia or a significant reduction in heart rate. Furthermore, labetalol has many important non-antihypertensive effects that may be beneficial in preeclampsia. It has an antiplatelet aggregation action, a thromboxane-reducing effect, and a fetal lung maturation-accelerating influence [Several previous TCD studies reported an increase in CPP, and growing evidence supports cerebral over perfusion theory and subsequent cerebral edema as a leading theory for cerebral injuries in preeclampsia patients with severe features [