Eligibility criteria
cardia cancers, Death, non-metastatic esophageal
TREATMENT COMPLICATIONS, RENAL IMPAIRMENT
The inclusion criteria were considered the patients aged ≥ 18 years with non-metastatic esophageal and cardia cancers who were candidates for chemo-radiotherapy and did not receive Proton pump inhibitors (PPIs) and other H2-blockers.Death during the study, being unable to continue treatment due to the severity of treatment complications, having renal impairment, being hypersensitive to H2-blockers, using any other H2-blockers (e.g. cimetidine) simultaneously and need to use PPI family medicines during the treatment process, caused an exclusion from the study.