Protection against homologous CHMI
STERILE
In cohort A, nine volunteers from the low-dose group, eight volunteers from the high-dose group, and three unimmunized control participants underwent a CHMI 19 weeks after the last immunization by the bites of five NF135-infected mosquitoes. All three control participants developed a positive qPCR (> 100 parasites/mL) on day 7 (Fig. Sterile protection against We determined the course of IgG antibody titers against Anti-sporozoite IgG titers. IgG antibody titers against sporozoite extract in sera of cohort A participants immunized with three times fifteen 