Discussion
NSCLC, vomiting, Nausea, CINV, malnutrition
LOSS OF APPETITE, NSCLC, MALNUTRITION
Nausea and vomiting are considered nutrition-influencing symptoms, and patients who experience CINV are particularly susceptible to malnutrition which in turn causes impairments in performance status and QoLA recent prospective study of NSCLC patients undergoing cisplatin-based HEC identified loss of appetite as one of the five most-frequent symptoms reported by patients within the chemotherapy cycleThere are several limitations in this study. First, this is a pre-planned exploratory analysis of the parent study, and the findings should be considered preliminary. Second, the current analysis was not designed as a nutrition trial. Since more detailed data about patients’ nutrition status were not collected, we did not account for their possible impact on our findings. Third, the qualitative data from the patient’s diary reflect only whether maintenance of daily food intake occurs or not but not the severity of the impact on food intake and its variation tendency during chemotherapy. Finally, the study assessment was not done in consecutive cycles of therapy since antiemetic efficacy could be evaluated only over cycle 1 in an investigator-initiated study. It is known that control of acute and delayed CINV in the prior cycle of treatment can influence the occurrence of delayed CINV in the subsequent cycle