Primary outcomes: MRI brain measures
Assessment will comprise the following MRI brain measures. Anatomical MRI: measures of cortical thickness at all points across the cerebrum. Resting State Functional MRI (rsfMRI): measures of functional connectivity throughout the brain. Cyberball Task-Related Functional MRI (fMRI): measures of brain activation throughout the brain in response to trust, mistrust (social exclusion), and rebuilding of trust (social re-inclusion). Diffusion Tensor Imaging (DTI): measures of fractional anisotropy and average diffusion coefficient.What these outcomes tell us about the brain MRI is an entirely safe way of imaging the brain at any age. It is routinely performed in unsedated people at multiple time points, including multiple time points within an RCT, and without the need for exposure to any radioactivity. MRI scanning can be performed in different modes, with each modality providing unique information probing different aspects of the brain’s structural and functional organization. 