Introduction
COLD
The COVID-19 pandemic has affected humans of all ages and conditions across the globe (Non-Pharmaceutical Interventions (NPI) including face masks, social distancing, individual isolation or lockdowns have shown to be effective in reducing the reproduction number (R) of SARS-CoV-2 (Intranasal photodynamic therapy (PDT) is an antimicrobial strategy based on the activation of a photoactive methylene blue-based compound within the anterior nares by a cold laser light (We hypothesized that an early eradication of viral particles from the anterior nares by nasal-PDT could reduce viral spread and infectivity in SARS-CoV-2 patients and that photochemical internalization (PCI) of post-treatment residual antigens into dendritic cells might impact on patients’ immune responses.