Acknowledgements
The authors thank the patients and their families for their willingness to participate in this trial, and all participants and research staff of all centers within SCCLG. Thanks to Dr. Chi-Kong Li of The Chinese University of Hong Kong for advice and critical review of the manuscript. This work was supported by grants in China from the Youth Talent Promotion project of the Guangzhou Association for Science and Technology (Grant No. X20210201015), The Medical Science and Technology Research Project of Guangdong Province (Grant No. A2021352), Basic and Applied Basic Research Project of Guangdong Province (Grant No. 2021A1515111169), the Science and Technology Planning Project of Guangzhou (Grant No. 202102020156), and the Science and Technology Planning Project of Guangdong Province (Grant No. 2014A020221008). The funder of the study had no role in the study design, data collection, data analysis, data interpretation, or writing of the report.