Study design
major depression
We requested patient-level data for all industry-sponsored, US Food and Drug Administration- (FDA) registered, placebo-controlled, acute-phase, and HDRS-based trials of adults with major depression regarding citalopram from Lundbeck (Valby, Denmark), regarding paroxetine from GlaxoSmithKline (Brentford, UK), and regarding sertraline from Pfizer (New York, NY, USA). We obtained data from all relevant studies except for three small, prematurely terminated trials: GSK/07 (In total, we used data from 8262 patients with major depression who participated in 28 SSRI trials. Participants were treated with either citalopram (