Statistical analysis
Data analysis was conducted using SPSS software (version 22.0 SPSS, Inc., Chicago, IL, USA). Control and intervention cases were matched based on the confounding variables (e.g. wound size). Data were described as mean ± standard deviation (SD). Welch test was used for comparing between groups. The Kaplan–Meier method was used for the analysis of time to healing. To compare the two survival curves, the log-rank test was used. Graphs were depicted by GraphPad Prism (version 8.3). 