Validation of plasma candidate biomarkers
To validate the candidate biomarkers selected by proteomic analysis, we enlarged the sample scale to 27-30 plasma samples from each group and reanalyzed the levels of the candidates PRDX6, GSTO1, GSTP1, GSTM2, FN1, and SERPINB9 via ELISA. Our results indicated that one marker for response to reactive oxygen species, PRDX6, and a platelet degranulation process marker, FN1, were significantly decreased after both treatments (Fig. ELISA validation of plasma candidate protein marker levels. Plasma levels of PRDX6 (