Contributions to the literature

The investigation documents that the PRECIS-2 and PRECIS-2-PS can be simultaneously used to feasibly and reliably rate randomized clinical trials with both patient and provider-level targets.The combined use of the PRECIS-2 and PRECIS-2-PS tools may provide clarity for clinical trial planning and grant submission and review, and enhance the quality of clinical trial protocol and main outcome manuscript publications.Future clinical trials research methods development could focus on continuum indicators/checklists that assess the extent to which clinical trials successfully catalyze health care system practice changes that are linked to pre-specified policy targets.