ARVAC CG booster induces significant increase of Th1-predominant cell response measured by IFN-γ and IL-4 ELISpot after restimulation of PBMCs with RBD spanning peptide pool.
Before booster administration (d1) and after 28 days (d28) of administration of ARVAC CG 25 μg (A second booster with ARVAC CG was given to the volunteers after 28 days to collect safety data after two vaccine administrations. The nAb titers remained significantly higher than baseline values (d1) after 42 days and 56 days of first dose administration (Supplementary Fig. 