RBCs release a cardioprotective factor during hypoxia.
hypoxia, ischemia
HYPOXIA, ISCHEMIA
First, we investigated whether RBCs exposed to hypoxia release a cardioprotective mediator by administration of RBC supernatant to an isolated heart subjected to global IR. To this end, the supernatant collected from mouse RBCs exposed to normoxia or hypoxia was given to mouse hearts at the onset of ischemia. The supernatant from RBCs exposed to hypoxia significantly improved postischemic cardiac recovery of left ventricular developed pressure (LVDP) (