2.3. Sample Size
SECONDARY
As this is a secondary analysis, the sample size was not estimated for the main outcome of the registered trial. However, we calculated that for a reduction from 8 to 7 points, as measured by the kPa parameter, shifting the Type II probabilistic error from 80 to 95% and setting the Type I probabilistic error to 0.05, 0.01, and 0.001, the sample size range would equal n1 = n2 = n3 = n4 = n5 = n6 = 20–30; with a power of 97% and Type I probabilistic error of 0.01 the sample size was estimated as 20 participants per group.