Resting-state functional connectivity
Since different MRI scanners were used in this study (Philips Achieva: n = 14; exercise = 12; control = 2; Philips Elition: n = 11; exercise = 2; control = 9) and there were clear differences between groups for which scanner was used, we first assessed whether scanner type was a significant covariate in a group × time RM-ANOVA model for DLPFC-sensorimotor network functional connectivity. Scanner type was not a significant covariate [Resting-state functional connectivity results from the seed-to-network analysis. (To determine if the significant decrease in DLPFC-sensorimotor network functional connectivity was a by-product of global changes in functional connectivity, we investigated the intra-network functional connectivity of the sensorimotor network. This analysis did not show any statistically significant differences between groups or time points.