Introduction
CRPS, pain
COMPLEX REGIONAL PAIN SYNDROME, NEUROLOGICAL DISORDER, PATHOPHYSIOLOGY
Complex regional pain syndrome (CRPS) is a rare pain condition with an estimated incidence of 26.2 per 100,000 person-years [Given the multifaceted nature of CRPS, an integrated multidisciplinary treatment approach is recommended [The pathophysiology of CRPS is not well understood, but it is thought to be a neurological disorder with prominent features of both central and peripheral sensitization [Soticlestat (TAK-935) is a first-in-class selective inhibitor of cholesterol 24-hydroxylase (CH24H; also known as CYP46A1) [Here we report findings from a pilot proof-of-concept phase 2a study, designed to examine the preliminary efficacy and safety of soticlestat as adjunctive therapy in participants with CRPS (ClinicalTrials.gov identifier: NCT03990649).