Introduction
DM, CKD, cardiovascular disease
CARDIOVASCULAR DISEASE, TYPE 2 DIABETES MELLITUS, CHRONIC KIDNEY DISEASE (CKD)
Chronic kidney disease (CKD) is a substantial public health burden worldwide that accelerates cardiovascular disease and leads to high rates of morbidity and mortality [There is now accumulating evidence, showing that a sodium-glucose cotransporter-2 inhibitor (SGLT2i) has distinct beneficial effects on renal and cardiovascular outcomes of patients with type 2 diabetes mellitus (DM) [SGLT2i has been shown to attenuate glomerular hyperfiltration via tubuloglomerular feedback system, which is linked to inhibit progression of CKD [