Identification of an intervention-independent exaggerated immune response to chemical exposure.
adverse skin reactions
ADVERSE REACTIONS, INFILTRATION
While adverse reactions to NM are common in high doses, the overall risk for severe skin reactions was hypothetically minimized in this study by using a low total dose of a topical NM gel that was FDA approved specifically for its lower incidence of adverse skin reactions (When we performed principal component analysis (PCA) with the RNA-Seq data, we found that samples taken from the same time point after NM exposure clustered together, as expected (Differential gene expression analysis at 72hrs P-I revealed that Severe participants upregulated 1,105 genes and downregulated 964 more genes (To characterize the tissue milieu in 72hrs P-I samples, we used xCell (To understand how Mild and Severe responses manifested clinically, we first evaluated histologic sections taken from both response groups. We observed that Severe responders tended to have more immune cell infiltration and less dermal-epidermal junction barrier integrity (