Significance
angina
EVENTS, ATHEROSCLEROSIS, SECONDARY
Opposed to native vessel atherosclerosis, neo-atherosclerosis is a process that may rapidly develops (within months) characterized by the presence of lipid-laden macrophages, within the neo-intima layer, secondary to dysfunctional endothelial coverage of the stent. Following a PCI, it is therefore of major interest to achieve a quick and functionally mature neo-intima layer covering the entire stent. This should be kept in mind since ISR not only is a problem because of angina relapse, but also since PCI in a restenosed vessel is associated with even a higher risk of major adverse cardiovascular events (MACE) than de novo PCI [