Choice of methods
In clinical trials, most often non-parametric methods are used to estimate DRMST and DS, while HR is almost always estimated using semi-parametric methods (i.e. the Cox proportional-hazards model). In this article, though, we additionally use fully parametric models to estimate all summary measures, in order to make a fairer comparison between them by using the same model. While using flexible fully parametric models to estimate HR is not expected to lead to noticeable differences compared to Cox models,