Conclusions
AD
OXIDATIVE STRESS
By enhancing two vital endogenous antioxidants, catalase and glutathione, sodium benzoate therapy improved cognition of patients with AD, with higher baseline catalase predicting better response. Supporting the oxidative stress theory, the results show promise for benzoate as a novel treatment for AD.Dementia is gaining increasing attention because of the high mortality and morbidity, which needs collaborative care.In addition to AChEIs, NMDAR antagonists have been developed to treat AD based on the ‘glutamate excitotoxicity theory’ for the middle‐late phase of AD.Sodium benzoate may play a neuroprotective role through reducing oxidative stress, based upon The current study aimed to find out the optimal dose of benzoate for the treatment of AD in a larger sample of patients (