Outcomes
MCI, amnestic MCI, amnestic, dementia
EVENTS
Our primary outcome for this analysis was a composite of adjudicated probable dementia or amnestic MCI. We chose to include amnestic MCI instead of any MCI for the following reasons. The definition of MCI in the original SPRINT protocol (ie, protocol-defined MCI) required 2 consecutive occurrences of MCI (amnestic or nonamnestic). For this analysis, to avoid conditioning the MCI outcome on future cognitive assessments and to include as many MCI events as possible, we chose to analyze the first occurrence of amnestic MCI, which has been consistently associated with the highest increased risk of progression to dementia.