Population characteristics at the time of randomization.
heart failure, death
HEART, LBBB, EVENT, SECONDARY, REGRESSION, HEART FAILURE, LEFT BRANCH BUNDLE BLOCK, CEREBRAL ISCHEMIA
Abbreviations: NYHA class, New York Heart Association; LBBB, left bundle branch block; HFC, heart failure clinic; PCI, percutaneous intervention; CABG, coronary artery bypass graft; TCI, transitory cerebral ischemia; NT-proBNP, amino-terminal-pro-brain-natriuretic-peptide; estimated GFRIn supplementary analyses, we included an analysis comparing groups based on the number of HF rehospitalizations. In 2-year survivors, patients were followed from 2 years following randomization until the event of interest, death, or 10 years following randomization. The absolute 8-year risk of the primary and secondary endpoints was estimated in groups defined by the number of HF hospitalizations (0, 1, or >1) within the first 2 years following randomization using the Aalen-Johansen estimator, incorporating the competing risks of death (Kaplan-Meier for all-cause death). We used a Cox regression model adjusted for numbers of prior HF hospitalizations to calculate hazard ratios with 95% confidence intervals of the primary and secondary outcomes comparing the PC and HFC groups. To analyze the main exposure in groups by the number of prior HF hospitalization, the interaction between the main exposure (PC vs HFC) and the number of prior HF hospitalizations was analyzed in the same Cox models.Lastly, we used consecutive claimed prescriptions to calculate the drug adherence level as a proportion of days covered (PDC) for RASi, BB, and MRA among 5-year survivors. PDC was calculated for each drug group separately as days exposed to the medication within the five years following randomization (PDC = days covered / 365.25*5). Zero one inflated beta-regression was used to calculate differences in means of PDC for each drug group between the PC and HF clinic groups.The significance level for all analyses was set to 5% (two-sided). All statistical analyses were conducted using R version 3.6.1 [