Trial site and participants
PDR
The trial was conducted in Siem Pang District, Stung Treng Province, a remote area in northeast Cambodia, which borders southern Lao PDR (Fig. Trial villagesIn 2020, the engagement activities took place in the context of an open-label, individually randomised controlled trial. The trial compared the efficacy of artemether-lumefantrine (AL) as anti-malarial chemoprophylaxis versus a multivitamin (MV), which does not have any anti-malarial properties. AL was provided as 4 tablets twice daily for 3 consecutive days, followed by twice-a-day weekly dosing for a maximum of 4 months. A multivitamin was provided as 1 tablet twice daily for 3 consecutive days and then weekly thereafter for the same duration. The engagement activities began in January 2020, two months prior to the enrollment in the trial, and continued throughout the trial period. Forest goers aged between 16 and 65 years who planned an overnight stay in the forest were invited to participate in the trial. Females with known pregnancy or breastfeeding were excluded. The trial protocol has been published elsewhere [