Introduction
HIE, Encephalopathy, Asphyxia
ENCEPHALOPATHY, ASPHYXIA, HYPOXIC-ISCHEMIC ENCEPHALOPATHY (HIE)
Neonatal hypoxic-ischemic encephalopathy (HIE) refers to the clinical presentation of a baby that has experienced reduced blood and oxygen flow to the brain near the time of birth. The diagnosis is typically made using a combination of clinical examination and laboratory findings within the first hours after birth.The High-Dose Erythropoietin for Asphyxia and Encephalopathy (HEAL) Trial was a prospective, randomized, placebo-controlled phase 3 trial in which newborns with moderate or severe HIE were randomized to receive erythropoietin or placebo in conjunction with TH.