Limitation
This was a single center study with a limited sample size. A larger sample size in a multicenter study could improve the power of the study. We did not study the effect of cortisol levels on the outcomes of patients and did not follow the final outcomes of patients in two groups. Based on the study protocol and method of randomization, we could not match our patients in terms of admission time. The cortisol serum level has a circadian cycle, and a difference in admission time may cause significant differences in the serum cortisol level. This caused a statistically significant difference in the baseline serum cortisol level between two groups in our study.