Conclusion
PWH, infections
INFECTIONS
The PCR-corrected therapeutic efficacy of AL among PWH in this setting was within the required range, but patients on an efavirenz-based regimen experienced lower lumefantrine levels than patients on other ART highlighting the importance of drug-drug interactions. Drug-drug interactions for common infections can alter pharmacokinetics and pharmacodynamics and have significant impact on individual and public health outcomes. Although efavirenz is largely being replaced by dolutegravir in sub-Saharan Africa, it will remain in use in a smaller population. In addition, this report highlights the need to consider common infections and associated pharmacokinetic interactions in the wider drug development and drug policy decisions.