Introduction
malignancy, breast cancer
BREAST CANCER
A common malignancy affecting women worldwide, breast cancer poses a serious threat to their life and health [There is widespread crosstalk between the HER2 and estrogen receptor (ER) signaling pathways, which contributes to resistance to both HER2-targeted therapy and endocrine therapy [Pyrotinib is an irreversible small-molecular tyrosine kinase inhibitor (TKI), which targeted HER1, HER2, and HER4 [