Study organization and time constraint
mistakes
Overall, the study took approximately 10 min to present the aims 30 min to explain the procedures in addition to a standard appointment time, 30 min of time dedicated to administrative procedures and data colelction (Table 
Additional time per week due to participating in the STOP RCT reported by health professionals implementing the trialIn addition, the other reported constraints relative to study organization are presented in Fig. But it also has been reported that participation in the study can have positive impacts on routine care and practices:
“[The intervention] helps address aspects of perception of nicotine substitutes and e-cigarettes that are not necessarily spontaneously addressed. It also makes it easier to discuss questions of preference related to the taste of NRTs, the concentration of e-liquids.“,“An improvement in my patient-centered approach”.Regarding participation in an academic research study, the following remarks were noted by participating health professionals:
“The times of care and research should be seperated”.“Multiplicity of studies with the fear of making mistakes and distorting the study”.“The overall workload at the public hospital, any study requires additional explanations and lengthens consultations”.“Several patients did not wish to participate in the study on principle, as they did not want to be included in a research protocol, even after I explained that it would not change anything in their treatment. Moreover, it is sometimes difficult to explain to patients the benefits of the study (their interest as patients) without mentioning the two randomized groups (without telling them that they may potentially receive free treatments).““The act of participating in an interventional study modifies practices (in any arm, for that matter).““The training for field research in primary care is not widely disseminated, and still not sufficiently integrated into practice. However, the daily operational question remains: on-site support from clinical research assistants would help ensure the proper conduct of research and a form of acculturation for primary care physicians.“The contribution of a clinical research assistant was noted three times as being valuable.