Funding
This work was funded by Qilu Pharmaceutical Co., Ltd., Jinan, China and partly supported by China National Major Project for New Drug Innovation (2017ZX09304015).Qilu Pharmaceutical Co., Ltd., Jinan, China played a role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication and as such is included in the author list and acknowledgments.