Eligibility criteria {10}
sleep disorder, alcoholic beverages/weekGood sleep, psychiatric, skin allergies, tooth
DISORDER, NEUROLOGICAL DISORDER, DENTAL DISORDER
Previous studies revealed that salivary metabolite profiles are (to a different degree) biased by sex, age, body mass index (BMI), oral hygiene, oral conditions, diet, medication, and lifestyle habits like smoking or alcohol consumption [Inclusion criteria:Male sexAge between 20 and 35 yearsUnderstanding and spoken command of the German languageGood health conditionBMI between 18.5–24.9 kg/mHabitual average sleep duration between 7 and 9 h/nightHabitual consumption of 3 or fewer caffeinated beverages/dayHabitual consumption of 5 or fewer alcoholic beverages/weekGood sleep quality: Pittsburgh Sleep Quality Index score ≤ 5Reasonable oral hygiene (≥ 1 tooth brushing/day)Normal or corrected-to-normal visionCar driving license holder since at least 2 years (obtained in a country with right-hand traffic) and regular driver (≥ 1 per week)Exclusion criteria:Two or more time zone crossings in the last 3 monthsHabitual napperHistory or presence of neurological disorder, psychiatric disorder, cardiovascular disorder, dental disorder, or any disorder that could pose a risk in participating or that could possibly influence study measurementsHistory or presence of a sleep disorder (screening night)Use of illicit drugs (urinary drug screening)Use of current medication (urinary drug screening) known to influence study measurementsExtreme chronotype (reduced Morningness-Eveningness-Questionnaire score ≤ 7 or ≥ 22)Current smokerHabitual use of energy drinks (> 1/week)Severe skin allergies or hypersensitivitiesFood allergiesHospital stay in the past 6 monthsShift worker, night workerRecent past (last 3 months) or present COVID-19 infectionFainting at the sight of blood or needlesParticipation in a clinical study less than 30 days ago or is currently participating in other clinical studiesSimulator sickness syndromeRefusal to sign informed consent