Histology of perivenous spaces
Alzheimer’s disease, pitting
Light microscopic analyses of frontal, parietal, and temporal brain regions revealed perivenous spaces, i.e., true conduits or cavities, situated between the brain parenchyma and the abluminal walls of intracerebral veins and venules (Fig. A network of perivenous spaces is identified on post-mortem brain specimens and corresponds anatomically with observed regions of MRI perivenous enhancement. Mild pitting is noted on coronal brain slices and is more prominent in persons with Alzheimer’s disease. 