Study population
In this double-blinded randomized clinical trial, 45 patients were enrolled and divided into three groups, all patients bone loss/ age were calculated to be ≤ 1. Group 1, MIST alone, was performed for 15 sites (8 males and 7 females with a mean age of 34.80±7.07); Group 2, MIST + placebo hydrogel applied in 15 sites (5 males and 10 females with a mean age of 34.50±6.31); and Group 3, MIST + RGD loaded hydrogel defect overfill for 15 sites (6 males and 9 females with a mean age of 34.70±6.88). No participant dropped out during the study period, and no data points were missing from the analysis (
