6. Conclusions
skeletal muscle mass
In patients with chronic HF with reduced LVEF, 12-week WPI supplementation promoted an improvement of body composition, evidenced by an increase in skeletal muscle mass and a decrease in body fat. Isolated (without accompanying physical exercise) WPI supplementation may be useful for these patients, who are frequently unable to exercise or are limited in their access to supervised exercise programs. The current results may help change the paradigm of the need for exercise during WPI supplementation, which is particularly useful in the specific population of HF patients.