Statistical analysis
We hypothesized that the carboplatin-containing neoadjuvant regimen could increase the pCR rate from 20 to 35% compared with the non-carboplatin neoadjuvant-containing regimen. Safety data were summarized descriptively for all patients who received at least one dose of study treatment. TEAEs leading to treatment interruption, dose reduction, or discontinuation of study drugs are reported.For the sample description, the frequency was used for the qualitative variables and average and standard deviation for the quantitative ones. Comparison between groups was performed using the 