Statistical analysis
REGRESSION
The sample size was calculated using a Simon's 2‐stage designThe main analysis included all patients who met the inclusion criteria and received at least one dose of sintilimab combined with anlotinib (intent‐to‐treat [ITT] population). The safety analysis was also performed in the ITT population. ORR and DCR were analyzed using the Clopper–Pearson method. PFS, OS, and DOR were estimated using the Kaplan–Meier method. Baseline demographics and safety data were summarized using descriptive statistics. Cox proportional‐hazards regression models were used for a univariate analysis to identify potential factors associated with clinical outcomes. All statistical tests were two‐sided, and 