Intervention
At enrolment, participants are randomised to receiving either closed-loop automated oxygen control (intervention group) or manual control of the inspired oxygen concentration. All infants are ventilated using the SLE6000 ventilators and ventilation settings are manually adjusted by the clinical team as per the unit’s protocol. In addition to standard care, infants in the intervention group are connected to the Oxygenie Auto-OThe nurse-to-patient ratio is according to the unit protocol that is determined on the patient’s acuity.Infants are studied from enrolment until successful extubation [Trial flowchart (Protocol v1.2, 10/11/2022)