CONCLUSIONS
critically ill
CRITICAL ILLNESS, CRITICALLY ILL
Our study showed plasma CCK and I-FABP2 concentrations decrease, whereas glucagon concentrations increase significantly during the first 5 days of pediatric critical illness, emphasizing the dynamics of these biomarkers. We did not find a significant association between the studied GI biomarkers and the amount of EN provided as a proxy of FI in the first 5 days of PICU stay. Based on the current evidence, these biomarkers appear to have no added value in predicting ENA in the first 5 days of pediatric critical illness. Studies using other approaches in combination with a clear definition of FI might be warranted to develop a diagnostic tool for feeding tolerance in critically ill children.