Other study parameters
REGRESSION
The relationship between physical activity and the percentage of FFM loss after 3, 6, and 12 months will be assessed as follows. For each time point, a linear regression model will be fitted with the percentage of FFM loss as an outcome. As a measure for the cumulative physical activity during the study period, an area under the curve of the total scores of the IPAQ-SF up to the time point under consideration will be calculated. The AUC measure, as well as the indicator variable for treatment allocation and its interaction, will be included as covariates in the regression model. Missing covariates (IPAQ-SF) will be completed by multiple imputation using chained equations (MICE) [Compliance with the protein intake will be evaluated by analysis of the diaries. For each patient cumulative intake will be calculated and compared between the intervention and placebo groups by simple descriptive statistics. In addition, trends in compliance over time will be explored and presented by descriptive statistics and/or visualized by means of for instance bar charts or box plots.