Multivariable Competing Risk Regression Estimate of sHR for Biochemical Progression in Fine and Gray’s Model
ONCOLOGY
Abbreviations: ECOG, Eastern Cooperative Oncology Group; RT, PSA, prostate-specific antigen; radiation therapy; sHR, subdistribution hazard ratio.SI conversion factor: To convert ng/mL to μg/L, multiply by 1.0.The multivariable model is also stratified by regions (US-Northeast, US-West, US-Other, Australia, New Zealand) and randomization arm.Age was included in the model as a continuous variable; parameter and hazard ratios of age are shown in per 5-year increment.The 3 significant factors associated with time to PSA failure were used to divide patients into 2 categories. The high-risk category was defined as being younger than 70 years, having a PSA of 10 ng/mL or higher, and having a Gleason score of 8 to 10. Otherwise, it was defined as low risk. Among the males in the high risk category, CIRs of PSA failure at 3 years was 43.8% (95% CI, 31.8%-55.2%) (eTable 2 in 