Background
RT-related damage, cancer, inflammation, pain, mucositis, salivary gland disorders, RT-induced injuries
TUMOR NECROSIS, INFLAMMATORY RESPONSES, PERIODONTAL INFECTION, CANCER, INFLAMMATION, VIRAL INFECTION, SALIVARY GLAND DISORDER, MUCOSITIS, HAND SWELLING, DISEASES, COMPLICATIONS
RT is a common and effective treatment modality for various types of cancer [Oral complications of RT in the head and neck include inflammation and swelling of the mucous membranes and skin, periodontal infection, fungal and viral infections, and salivary gland disorders [These lesions are due to the local effect of ionizing radiation on the oral mucosa and differ from one patient to another depending on oral hygiene, radiation levels, specific diseases, and smoking [So far, various methods have been introduced for the prevention and treatment of mucositis (e.g. laser and cryotherapy, topical medications, antibiotics and antiseptics, antifungals, anti-inflammatory agents, cellular protectors, immunosuppressant, anesthetics, and use of normal saline mouthwashes, baking soda, betadine, and Chlorhexidine); however, none of these methods managed to completely reduce mucositis [Curcumin, a diferuloylmethane, is a phenolic compound. The active ingredient of the rhizome of the plant is turmeric which makes up about 2 to 8% of turmeric compounds [Curcumin interferes with inflammatory responses can reduce the activity of cyclooxygenase-2, lipoxygenase, and nitric oxide synthetase, and inhibit the production of inflammatory cytokines such as alpha tumor necrosis factor (TNF-alpha) [Curcumin may improve morphine function at high doses by suppressing pain transmission pathways. These effects are due to analgesic chemical mediators such as serotonin, dopamine, and noradrenaline, whose release was increased by curcumin to reduce pain [Various medicinal products are currently available to relieve and treat the RT-related damage in cancer patients. In addition to their therapeutic properties, these chemicals suffer from their own side effects. The use of herbal medicines is recommended to prevent and increase tissue resistance and ultimately reduce the severity of RT-induced injuries [