Baseline characteristics.
COMMON COLD, COLD, ACUTE LARYNGITIS
From October 8, 2018, to October 22, 2018, we recruited 48 healthy volunteers with an average age of 26.6 years (Overview of the study design and sample collection. The healthy volunteers (Demographics of healthy volunteers at baselineIQR, interquartile range; NA, not applicable; SD, standard deviation.All the participants resided in Beijing, China. Most of them lived in the Chaoyang district, while others lived in the Changping, Shijingshan, Haidian, Dongcheng, and Fengtai districts.Other occupations included physicians, company employees, and civil servants.Diversity of the baseline sputum microbiota of the healthy volunteers using samples collected before drug administration.Compared by two-sided Wilcoxon rank sum test.Compared by two-sided Student’s Compared by two-sided chi-squared test with continuity correction.Compared by two-sided Pearson’s chi-squared test.Compared by permutational multivariate analysis of variance (PERMANOVA).Data of sputum samples collected at different time pointsThe sputum samples were collected before the day of drug administration (D0), the day after the treatment course was completed (D4), and at 14 days (D14), 30 days (D30), and 60 days (D60) postdosing. A total of 38 of all the subjects completed the five time points. Six subjects had a cold at time point D30. Three subjects had common cold at time point D60. One subject was diagnosed with acute laryngitis after time point D0. All dropouts were lost to follow-up right after the last visit.