Author contributions
CB and RP conducted the statistical analyses and drafted the manuscript. CB, RP, and JT made substantial contributions to the conception and design of the manuscript. All authors contributed substantially to the acquisition of data or analysis and interpretation of data, revised the manuscript critically for important intellectual content, and approved the final version to be published.The authors especially thank the PREDIMED-Plus participants for their enthusiastic collaboration, the PREDIMED-Plus personnel for outstanding support, and the personnel of all associated primary care centers for their exceptional effort. CIBEROBN, CIBERESP, and CIBERDEM are initiatives of Instituto de Salud Carlos III, Spain. We thank the PREDIMED-Plus Biobank Network, part of the National Biobank Platform of Instituto de Salud Carlos III for storing and managing biological samples.