Abbreviations:
hypercholesterolemia
HYPERCHOLESTEROLEMIA
atorvastatin 10 mgatorvastatin 5 mgatorvastatin 5 mg and ezetimibe 10 mgatherosclerotic cardiovascular diseaseezetimibe 10 mghigh-density lipoproteinlow-density lipoproteinThis study was initiated and supported by the Addpharma Co., Ltd.Supplemental Digital Content is available for this article.The authors have no conflicts of interest to disclose.This randomized, double-blind, placebo-controlled trial comparing the effects of A5E combination therapy to E, A5, and A10 monotherapy on lipid levels and their safety profiles in patients with hypercholesterolemia was conducted at 19 centers in Korea (ClinicalTrials.gov identifier: NCT05131997). The institutional review board at each site approved the study protocol, and all subjects provided written informed consent. All methods were carried out in accordance with relevant guidelines and regulations.Written informed consent was obtained from all individual participants included in the study.All data generated or analyzed during this study are included in this published article [and its supplementary information files].How to cite this article: Lee S-A, Hong SJ, Sung J-H, Kim K-S, Kim SH, Cho JM, Chun SW, Lee SR, Kim CS, Kim TN, Kim DH, Park H-C, Kim BJ, Kim H-S, Choi J-Y, Hong YJ, Chung JW, Yoon SB, Lee S-H, Lee CW. Effectiveness of low-intensity atorvastatin 5 mg and ezetimibe 10 mg combination therapy compared with moderate-intensity atorvastatin 10 mg monotherapy: A randomized, double-blinded, multi-center, phase III study. Medicine 2023;102:47(e36122).