Primary and Secondary Outcomes
paraplegia
REGRESSION, PARAPLEGIA, CONNECTIVE TISSUE DISORDER, SOLID TUMOR
Abbreviation: NA, not applicable.Only nonzero values included in calculations.Calculated using χCalculated using Calculated using Kruskal-Wallis test.As aforementioned, there were somewhat larger baseline differences between the intervention and control groups for 3 variables: paraplegia, solid tumor, and connective tissue disorder (each with SMD >0.10). A multivariable linear regression controlling for these 3 variables was essentially unchanged from the unadjusted analysis, with no appreciable effect on either the statistical significance of between-group differences or the β coefficient of the pressure difference between the intervention and control groups.In the non-prespecified subgroup analysis comparing outcomes in the intervention and control groups, stratified by ICU vs non-ICU care setting, we observed a median (IQR) pressure difference of 0.39 (0.37-0.41) for non-ICU care vs 0.15 (0.12-0.18) in the ICU care setting (Box plots for both primary outcomes and subgroup analyses are presented in 