Higher concentration of nelfinavir in lung and bronchoalveolar lavage (BAL) fluid
Nelfinavir have a high concentration in lung. In rats, the lung-to-plasma ratio of nelfinavir is 3.24, detected at 4 h after oral administration.Other HIV protease inhibitors, i.e., lopinavir-ritonavir, have been shown to have insignificant benefit in COVID-19 patients