4.3.1. Ozone Therapy
Patients of Group A received an IA injection of a mixture of oxygen–ozone (total of 10 mL) with an O3 concentration of 10 μg/mL, obtained by means of a Multiossigen Medical 99 IR generator (Multiossigen s.r.l., Gorle, Bergamo, Italy). The machine converted medical oxygen into a mixture of O3 (0.05%) and O2 (99.95%) through an electrochemical process. It was equipped with a photometer, calibrated according to the standard iodometric titration of O3, and a voltage system that regulated the concentration.