Acknowledgements
We thank all participants and their relatives for being a part of this trial. This work was supported by Boehringer-Ingelheim Pharma GmbH, Ingelheim, Germany, the National Natural Science Foundation of China (Grant No. 82125001), Innovation Program of Shanghai Municipal Education Commission (Grant No. 2023ZKZD33), and Clinical Research foundation of ShangHai Pulmonary Hospital (grant No. FKLY20004). The sponsor and funders had no role in study design, data collection, data analysis, or manuscript writing.