Objectives of the new study: the ADEM2 study
wheezing, asthma, exhaled breath
PATHOGENESIS, ASTHMA
The previous ADEM study generated a lot of insight in the diagnostic potential of VOC patterns in exhaled breath with respect to an early diagnosis of asthma, and in multiple potential underlying pathophysiological mechanisms leading to the development of asthma. However, since then, many new questions arose. For example with regards to the feasibility of bringing the assessment of VOCs in exhaled breath into daily clinical practice, and with respect to the impact an early diagnosis of asthma will have on wheezing preschool children and their parents. Also, recent developments in the evolving field of multi-omics generated new approaches to investigate the early pathogenesis of asthma. Therefore, a new randomised controlled trial and prospective study in wheezing preschool children was designed, the ADEM2 study.The primary objective of the ADEM2 study is to prove health gain and reduction in costs by application of a point-of-care (POC) breath test for an early asthma diagnosis in preschool children. A multicentre randomised controlled trial (RCT) in 220 wheezing preschool children will be performed. Children will be randomised into an intervention group (