References
Study design and flow-chart. (Community profiles of gut mycobiome during the interventions. (Descriptive overview of gut fungal genera for each individual over the 12 timepoints. In total, 10 to 12 fecal samples were analyzed per participant collected across the 12 timepoints, and only the fungal genera that were considered present were included in this plot. A fungal genus was considered present if detected among ≥ 50% of the sampling points. HC dietary interventions are shaded in light yellow, whereas LC dietary interventions are shaded in grey. “Changes of gut fungal alph -diversity during the dietary intervention. (Principal coordinate analyses plot showing gut fungal community structure measured by Bray–Curtis dissimilarity before and after the dietary intervention. (Changes in relative abundance of core diet-related fungi before and after the interventions. The box plots compare the relative abundance of 10 core diet-related fungi before and after the interventions calculated from mean values of the three intervention sets. All box plots are expressed as the median with the interquartile range. All The association between the gut mycobiota and glycemic phenotypes by the dietary intervention period. Forest plot shows the interaction of dietary intervention with gut mycobiota on glycemic phenotypes. Fungal relative abundance and CGM features were calculated as mean values during each HC or LC dietary intervention separately. Associations were expressed as the difference in glycemic traits per 1 SD increment of gut mycobiome abundance. Linear mixed models were performed, adjusted for age, gender, and BMI. Abbreviations: MPG, maximum postprandial glucose; AUCBaseline characteristics of the WE-MACNUTR study participants.Data are presented as mean ± standard deviation or number (%). BMI, body mass index; LDL, low-density lipoprotein; HDL, high-density lipoprotein.