LIMITATIONS
EVENTS
This study's limitations need to be discussed. Our phase 2 data were insufficient to examine cardiovascular events and mortality. Therefore, we could not determine the MW parameters' prognostic threshold values, which prevented us from demonstrating how MW parameters would affect the study's endpoint. Otherwise, no echocardiographic data were collected pre‐randomization. Additionally, we lack laboratory test results for further repeated analysis. The slightly poor quality of echocardiographic images may affect how the LV mechanics and MW were evaluated during echocardiography. Clinical research was unavoidable and did not introduce relevant bias. This study measured MW parameters utilizing clinic‐visit SBP rather than supine BP recorded during the echocardiography. The MW technique used the brachial artery BP rather than the LV wall stress to estimate LV pressure, ignoring the effect of the LV's absolute size and the wall curvature.