Limitations of the study
neurocognitive deteriorations, AMS
This study focused on visuomotor performance and did not assess other neuropsychological functions such as language, short-time memory, and executive functions, since deteriorations of these functions have been seldomly detected at altitudes around 3,000 m. Worsening of visuomotor performance on the other hand have been observed below 3,000 m [It is known that savings of adaptation to visuomotor rotation can be observed not only days, but also months after previous testing, with the DE decreasing with every repetition of the test [AMS scores were low in both groups. Therefore, no inferences regarding the incidence of AMS, effect of acetazolamide and neurocognitive performance could be drawn. On the other hand, this study illustrates that neurocognitive deteriorations can be measured before symptomatic AMS can be detected.The participants of the current study were of predominantly urban origin, slightly overweight, most likely reflecting their sedentary lifestyle, and familiar with the use of electronic devices. It remains uncertain whether people from another socio-economic background would perform differently in MTM tests. The lack of sleep EEG recordings prevented a further analysis of the effect of acetazolamide on sleep structure and its correlation with neurocognitive performance.