1. Introduction
obesity, obese, overweight, weight loss
OBESITY, OVERWEIGHT AND OBESITY, OBESE
Studies investigating the effect of multispecies synbiotic supplementation in obesity management are limited. The current study was performed to evaluate the effects of multispecies probiotics mixed with fructooligosaccharides on body composition, antioxidant status, and gut microbiome composition in overweight and obese individuals. We employed a randomized, double-blind, placebo-controlled trial design, in which 63 individuals aged 18–45 years were assigned to receive either a synbiotic supplement or placebo for 12 weeks. The synbiotic group consumed a daily dose of 37 × 10Overweight and obesity can be attributed to a complex interplay of multiple factors that result in a dysregulated energy balance in the body, leading to an abnormal accumulation of adipose tissue or body fat. The prevalence of overweight and obesity has been recognized as a common epidemic and a crucial public health problem of the twenty-first century [Dietary interventions that include probiotics, prebiotics, or synbiotics (a combination of probiotics and prebiotics) have been discovered to restore the gut microbiota observed in obese individuals and promote weight loss and maintenance [Despite some evidence that synbiotics may help reduce obesity and its associated consequences, research on the effect of synbiotics with multiple probiotic species in overweight and obese participants is limited. Therefore, the current study seeks to evaluate the impact of a specific multispecies synbiotic supplement, containing a blend of seven probiotic strains and fructooligosaccharides, on body composition, antioxidant levels, and gut microbiome composition in overweight and obese individuals. 