Bosutinib exposure metrics
SOLID TUMORS
Individual bosutinib plasma exposure estimates were used to assess potential exposure‐response relationships. Bosutinib exposure metrics were calculated from a population PK model, which was a two‐compartment model with first‐order absorption and an absorption lag time. The PK model was based on pooled data from 10 clinical studies: a Phase 1 study of bosutinib in advanced solid tumors (NCT00195260)