Introduction
SECONDARY, COMPLICATIONS
The “timed inspiratory effort” (TIE) index, a new predictor of weaning outcome, normalizes the maximal inspiratory pressure with the time required to reach this value up to 60 s, incorporating the time domain into the assessment of inspiratory muscle function. The objective of this study was to determine whether the TIE predicts successful extubation at a similar rate as the T-piece trial with less time required. A non-inferiority randomized controlled trial was performed with ICU subjects eligible for weaning. The participants were allocated to the TIE or the T-piece groups. The primary outcome was successful weaning, and the main secondary outcome was ICU mortality. Eighty participants of each group were included in the final analysis. Time from the start of a successful test to effective extubation was significantly lower in the TIE group than in the T-piece group, 15 (10 to 24) In the intensive care environment, mechanical ventilation is an essential technique for life maintenance. However, it can be associated with several complications and increased costs related to the procedure's duration (A recently described weaning predictor, the “timed inspiratory effort” (TIE) index, normalizes maximal inspiratory pressure (PImax) by time required to reach this value, thus incorporating the time domain into the assessment of inspiratory muscle function (One issue to consider about the weaning and extubation process is the time it takes to decide whether to extubate (