2.4. Statistical Analysis
Data were analyzed using intention to treat by means of the Statistical Package for Social Science (SPSS) 25.0, version for Windows.The sample size was calculated for the change in LDL-C. By enrolling 45 subjects in this two-treatment crossover study, the probability is 90 percent that the study would detect a treatment difference at a two-sided 0.5 significance level, if the true difference between treatments is 5%. This is based on the assumption that the within-patient standard deviation of the response variable is 18. A total sample size of 50 subjects (25 subjects/treatment sequence) was then used in the study to allow for a dropout rate of 10%.The Kolmogorov–Smirnov test was used to test the normality distribution of the studied variables. Baseline characteristics of the population were compared using Levene’s test followed by the independent Student’s 