Discussion
pneumonia, fever, Immunosuppression-associated pulmonary infections, adenovirus pneumonia, cyanosis, Fever
PNEUMONIA, RESPIRATORY FAILURE, ADENOVIRUS PNEUMONIA, REGRESSION, EVENTS
Immunosuppression-associated pulmonary infections are the most common site of CTD and may present with acute respiratory events (respiratory failure, ventilatory support) with a significant impact on mortality (We used two machine learning algorithms to obtain prognostic variables. Shiroshita et al. found low predictive performance when they used a single machine learning algorithm to construct a model for predicting in-hospital mortality in patients with chronic obstructive pulmonary disease pneumonia exacerbations (A multivariable stepwise Cox regression analysis showed that five factors (fever, cyanosis, blood urea nitrogen, ganciclovir, and anti-pseudomonas) are prognostic risk factors for CTD pneumonia patients. Fever is a regulated increase in body temperature caused by the upward shift of the thermoregulatory point due to the action of a thermogenic source. Studies have reported that a longer duration of fever is a risk factor for poorer prognosis in children with severe adenovirus pneumonia (In this study, a nomogram was created based on these independent risk factors. This study had some advantages over the PSI and the CURB-65. First, the model in this study did not include the age variable, which has stronger applicability than the PSI or the CURB-65. Second, the subjects of this study were patients with pneumonia using glucocorticoids or/and immunosuppressants for CTD. Compared with PSI and CURB-65, this model is suitable for specific populations. However, this study also has some limitations. First, this study was validated using an internal validation cohort and the results have not been further confirmed using an external validation cohort, and caution is needed in clinical use. Furthermore, this study was based on data collected from six hospitals in China, and the applicability of the model to Western cohorts needs further confirmation.