Analyses
We used descriptive statistics to summarize our study sample, clinical measures, and accelerated DNAm age [Horvath Age, Hannum Age, GrimAge, PhenoAge, and DunedinPACE, as well as intrinsic (IEAA) and extrinsic (EEAA) epigenetic age acceleration; EEAA adjusts for blood cell proportions whereas IEAA is independent of blood cell proportions). Accelerated Horvath Age, Hannum Age, GrimAge, and PhenoAge were calculated from the difference between DNAm age and chronologic age, with positive values suggesting faster aging and negative values reflecting slower aging. DunedinPACE was calculated using “DunedinPACE” R package [Given our small sample size and the exploratory nature of our study, we pre-specified 