Introduction

DISEASE, HIV PERIODONTITIS
The mouth supports the second largest and most diverse microbial community found in the body after the gut, including approximately 700 bacterial species. According to the expanded Human Oral Microbiome Database (HOMD), only 57% of oral bacteria have been officially named, whereas 13% are yet unnamed although cultivated, and 30% are uncultivated[Periodontal disease has been traditionally linked to a higher subgingival bacterial count and to a prominent relative presence of certain pathogenic bacteria, such as Non-surgical periodontal therapy is proven to induce a positive shift in the microflora through the mechanical removal of biofilm and a trigger of the immunological response[To date, a few studies have investigated the clinical effects of air-polishing in the initial treatment of patients with periodontitis[The aim of the present randomized controlled clinical trial was to evaluate the subgingival microbial community profile of patients affected by stage III–IV periodontitis treated via Guided Biofilm Therapy protocol[