Exploratory analyses
TILs
As a post hoc exploratory analysis, we compared the high-risk groups with TILs 10–49% and 50–100% to investigate a potential dose-response relationship. Unirradiated patients with TILs 10–49% had a 10-year cumulative IBTR incidence of 15% (0.07–0.29). Unirradiated patients with TILs 50–100% had a lower, but not significantly different, cumulative IBTR incidence of 13% (0.05–0.31) (Finally, to verify the stability of the results, we re-ran the main analyses excluding patients treated with systemic therapy. The findings remained stable (