Pharmacokinetic analysis
All 48 subjects completed the study, and the data were included in the pharmacokinetic analysis. According to the actual blood collection time, the pharmacokinetic parameters were calculated using the non atrioventricular model by WinNonlin®8.3.1 (pharsight, St. Louis, Mo, USA). In the concentration data list, for the samples which concentration is lower than the lower limit of quantification, the samples before reaching C