Abstract
premenstrual syndrome, inflammation, primary dysmenorrhea
PREMENSTRUAL SYNDROME (PMS), PMS, INFLAMMATION, DYSMENORRHEA, PRIMARY DYSMENORRHEA, PREMENSTRUAL SYNDROME
Premenstrual syndrome (PMS) and primary dysmenorrhea are common gynecological problems and inflammation may have a role in their etiology. Curcumin is a polyphenolic natural product for which there is increasing evidence of anti‐inflammatory and iron chelation effects. This study assessed the effects of curcumin on inflammatory biomarkers and iron profile in young women with PMS and dysmenorrhea. A sample of 76 patients was included in this triple‐blind, placebo‐controlled clinical trial. Participants were randomly allocated to curcumin (Curcumin supplementation significantly decreased serum levels of high‐sensitivity C‐reactive protein (hsCRP) in women with premenstrual syndrome and dysmenorrhea, but could not affect hematological inflammatory parameters including white blood cells (WBC) count, neutrophil percentage, mean platelet volume (MPV) and red blood cell distribution width (RDW). Curcumin was well‐tolerated, and none of markers of iron metabolism statistically changed after intervention.
