Power analysis
To confirm the statistical power to detect a significant difference between R and NR patients, we conducted a post hoc power analysis using sample size and a hypothesis of effect size to detect. We used in all our comparisons a significance level of 0.05 and assumed a two-tailed test. The reported comparison includes the differential analyses at each time point between R and NR patients using both gene expression and methylation profiling. With an estimated guess of effect size (Cohen’s 