Author Contributions
The study was designed by D.B., C.L.O., C.D. and M.M. All aspects of the clinical trial were performed by C.L.O. DNASense was used to perform the DNA sequencing, cytokine activity was measured at Turku University by M.G. and U.K.G., and protease activity and albumin concentration were analyzed at ACTA University by A.V.S. and F.J.B. The biostatistical analyses were performed by V.F.D.V., L.M. and C.L.O. The DNA sequencing and statistical analyses performed using DNASense were executed as a pay-for-service. The first draft of the manuscript was written by C.L.O. and D.B. and critically revised by C.D., M.M., V.F.D.V., L.M., U.K.G. and F.J.B. All authors have read and agreed to the published version of the manuscript.