Randomization and treatments
Participants were allocated in a 1:1 ratio to receive either sacubitril/valsartan treatment (intervention group) or conventional medical therapy (control group). The randomization sequence was computer-generated. A specialist who was not involved in the trial performed the randomization process. Sacubitril/valsartan 200mg once daily or conventional medical drugs (Valsartan 160mg once daily) were given as soon as possible within 24 hours of randomization, and other post-admission treatment regimens remained as consistent as possible. Over the course of more than 3 months, sacubitril/valsartan has been given.