Methods
This prospective randomized study enrolled 436 female patients undergoing
ICSI cycles from January/2018 to June/2021, in a private
university–affiliated IVF center. Female patients were randomized in a 1:3
ratio to either Control (n=109) or Supplementation Group (n=327). All
patients received nutritional orientation before the beginning of the
treatment. Participants in the Supplementation Group were instructed to
intake a daily dose of homemade juice, prepared with fresh beetroot,
watermelon and ginger, from the day of embryo transfer until the day of
pregnancy test, while patients in Control Group did not follow the juice
protocol. Generalized Linear Models, adjusted for potential confounders
(female age, body mass index - BMI, endometrial thickness upon embryo
transfer, and number of transferred embryos), followed by Bonferroni post
hoc test for the comparison of means between groups, were used to
investigate the impact of juice supplementation on the clinical outcomes of
ICSI.