RAPNO criteria (secondary endpoints)
tumor, SD, PD, BOR, MR, tumors
MINOR, TUMORS, TUMOR
The ORR per RAPNO criteria was 51% (95% CI: 40–63), including 28 (37%; 95% CI: 26–49) patients with a PR (≥50% reduction from baseline by sum of the product of the perpendicular diameters (SPPD)) and 11 (14%; 95% CI: 8–24) patients with a minor response (MR; 25–49% reduction from baseline by SPPD). Twenty-three (30%) patients had a BOR of SD, resulting in a CBR of 82%. The ORR was similar in patients with tumors harboring Figure Thirteen (17.1%) patients initially had a best overall response of PD according to RAPNO criteria per IRC evaluation but continued tovorafenib treatment due to the absence of PD by RANO-HGG criteria per investigator, consistent with the trial design and primary endpoint assessment. All but two patients had no symptoms or signs of clinical progression. Plots of tumor size (SPPD) over time in several of these patients showed subsequent tumor shrinkage after the initial assessment of PD (Extended Data Fig. 