Main Points
gastroesophageal reflux disease
GASTROESOPHAGEAL REFLUX DISEASE
Acid suppression, especially proton pump inhibitors, is widely accepted as the cornerstone of medical treatment of gastroesophageal reflux disease.It is estimated that around 30% of patients with diagnosis of gastroesophageal reflux disease are refractory to proton pump inhibitors so attempt for evaluation of new medication for gastroesophageal reflux disease pharmacotherapy is necessary.Melatonin has been used for the treatment of gastroesophageal reflux disease symptoms successfully but there is a concern regarding poor bioavailability of melatonin from gastrointestinal tract. So in the present trial, the aim was to investigate whether the addition of sublingual melatonin to omeprazole was effective in the treatment of gastroesophageal reflux disease symptoms.