Body Composition
Body composition components (fat, lean, and bone mass) were measured with a third-generation DXA scanner (DXA Lunar Prodigy Primo and Lunar iDXA; GE Healthcare) connected with enCore software by trained operators at baseline, 1-year, and 3-year follow-up. Operational definition of regions of interest for body composition measured with DXA is available in the eMethods in For visceral fat measurements in an android region, DXA scans were reanalyzed using CoreScan software application (GE Healthcare) validated using computed tomographic scans as a reference tool.