Statistical analysis
Sample size calculations were performed with G*Power (Statistical analyses were performed using IBM SPSS software version 27.0. A
factorial repeated-measures ANOVA was conducted to analyze the main and
interaction effects of time and treatment on the VigTrack and PVT parameters.
When the average test revealed a significant overall difference, pairwise
comparisons were conducted to analyze the difference between treatments. These
consisted of paired comparisons between scores and between treatment conditions
for all separate test sessions (least significant difference). SSS scores were
analyzed by nonparametric tests (Friedman test for repeated measures and
Wilcoxon matched-pairs signed-rank test for pairwise comparisons). The placebo
group was included for reference purposes.For all primary endpoints, the change from baseline, defined as the difference
between the measure before drug intake (