Statistical analysis
All statistical analyses were performed using Statistical Package for Social Sciences version 27.0 (SPSS Inc, Chicago, IL, USA). Variables with normal distribution were expressed as mean ± standard deviation. Variables with non-normal distribution was expressed as median (interquartile) and range. Continuous variables with normal distribution were analyzed using student t-test while to compare between the two groups: interventional and non-interventional group. The categorical data was tested with Pearson Chi-square test and Fisher exact test. The results of the data between the two groups were analyzed using Wilcoxon Sign Rank Test or its equivalent non-parametric chi square test for parameter with non-normal distribution. Statistical significance declared when 