PK evaluation
BLOOD
Blood samples for the assessment of PK parameters were collected at predefined time points during the DLT observation period as follows: Cycle 0 Day 1 (predose; 0.5, 1, 2, 4, 8, and 12 h postdose), Day 2 (24 h postdose), and Day 3 (48 h postdose); Cycle 1 Day 1 (predose), Day 8 (predose), Day 15 (predose), Day 21 (predose; 0.5, 1, 2, 4, 8, and 12 h postdose), Day 22 (24 h postdose), Day 23 (48 h postdose), and Day 24 (72 h postdose). Plasma SYHA1813 levels were measured using a validated high-performance liquid chromatography‒mass spectrometry method.Single- and multiple-dose PK parameters of SYHA1813 were estimated using noncompartmental analysis, including maximum observed plasma concentration (C