Efficacy
The Eradication rate of each treatment group.*P-values were obtained from two-sided comparisons of the difference between the L-VA group and the H-VA group; †The P values were obtained from one-sided test comparisons of non-inferiority between the L-VA group and the H-VA group. ITT, intention to treat; PP, per protocol; L-VA, dual therapy consisting of low-dose amoxicillin (1000 mg b.i.d.) and vonoprazan (20 mg b.i.d.); H-VA, dual therapy consisting of high-dose amoxicillin (1000 mg t.i.d.) and vonoprazan (20 mg b.i.d.).The lower bound of the adjusted 95% CI for the efficacy difference between L-VA dual therapy and H-VA dual therapy was greater than the prespecified non-inferiority margin in the ITT and PP analyses. No differences in the eradication rate between the two groups were observed according to ITT and PP analysis.