Background
Postoperative pain, postoperative pain
Postoperative pain following root canal treatment has remained a challenge for dental clinicians [After the chemo-mechanical debridement of the root canal, the root canal filling materials are used to seal the disinfected canal. Ideally, root canal filling materials should be easy to handle, nonirritating for periapical tissues, radiopaque, bacteriostatic, and should not shrink after application [Bioceramics are biocompatible and bioactive materials that possess optimal dimensional stability, antibacterial activity [To the best of our knowledge, there is no research evaluating the role of root canal filling materials on endodontic postoperative pain. Although some animal models indicated that the MTA induces some analgesic effects and reduces nerve activity [