Sample collection and analyses
BLOOD
Blood samples to measure baseline and trough levels of serum ravulizumab, serum free C5 (pharmacodynamics), and anti-drug antibody (ADA) evaluation were collected pre-dose (within 30 min before the start of infusion of study drug). Blood samples for peak post-treatment serum pharmacokinetic and pharmacodynamic assessments were taken within 30 min after completion of study drug infusion. Blood samples were obtained at baseline and at Weeks 2, 10, 18, and 26. Samples were refrigerated (2–8 °C [36–46 °F]) after processing and shipped on ice to the analysis site.