Statistical analyses
Analysis of molecular recurrence-free survival was performed using Graphpad Prism (GraphPad software, version 8.0.1). To compare variables between groups, the Mann Whitney test or the Wilcoxon test was performed when appropriate. Quantitative variables were dichotomized using the ROC curves, and cut-off points were established according to the highest likelihood ratio, maximizing specificity. Survival curves were compared using the log-rank test. Correlation was assessed with the Spearman test. P values < 0.05 were considered statistically significant.