1. Introduction
hemolysis
IRON DEFICIENCY, HEMOLYSIS, INTESTINAL BLEEDING, INFLAMMATORY RESPONSE
The purpose of this study was to determine the effects of pre-exercise amino acid (AA) supplementation on post-exercise iron regulation. Ten healthy males participated under two different sets of conditions in a randomized, double-blind, crossover design with a washout period of at least 21 days. Participants received either an AA supplement or placebo (PLA) for five consecutive days (4 g/dose, 3 doses/day). On the sixth day, participants ran on a treadmill for 60 min at 70% of maximal oxygen consumption (Iron plays an important role in the transport of oxygen to working muscles during exercise, and adequate iron levels are essential for optimal physical performance [The high prevalence of iron deficiency in athletes is likely due to exacerbated exercise-related iron loss, which cumulatively results from intestinal bleeding, hemolysis, and sweating [Several studies have shown that strenuous exercise increases serum hepcidin levels post-exercise [Many researchers have focused on the effects of amino acid (AA) supplementation on muscle protein synthesis, exercise tolerance, and performance [Therefore, the purpose of this study was to determine the effects of AA supplementation on the inflammatory response and iron regulation after a single bout of endurance exercise. We hypothesized that AA supplementation would inhibit IL-6 production and attenuate the increases in exercise-induced hepcidin levels.