Differences in lipids between IPF and healthy controls
IPF
REGRESSION
The baseline characteristics of patients with IPF and the age- and sex-matched healthy controls are shown in Patient baseline characteristics of CAPACITY-006 studyDLCO%pred, percentage of predicted diffusion capacity of carbon monoxide; FVC%pred, percentage of predicted forced vital capacity.Data are n (%), mean (SD).A total of 206 lipid species were significantly upregulated in patients with IPF, including many of the LPA precursors such as phosphatidylcholine (PC), phosphatidylethanolamine (PE), LPC, and lysophophatidylethanolamine species; a total of 22 lipid species were significantly downregulated in patients with IPF compared to controls (FDR < 0.05) (Comparison of lipid levels between healthy controls and IPF. A multivariate linear regression model adjusted for age and sex was used to assess the differences in lipid levels between healthy controls and patients with IPF. The x-axis indicated log2(analyte abundance in IPF/analyte abundance in healthy controls), and the y-axis indicates −log10(adjusted We focused on these 7 lipid species and assessed their baseline association with demographic and clinical measures. In healthy controls, LPA18:2 levels were higher in females than males (