Adverse reactions
diarrhea, hypoglycemic reactions
ADVERSE REACTIONS, EVENTS, HYPOGLYCEMIC REACTIONS
After 12 weeks of treatment, there were no statistically significant changes in ALT, AST, Cr, and UA in any of the groups (P>0.05). The three treatment regimens did not show any severe hypoglycemic reactions during any of the study phases. There were no significant differences in the hypoglycemic responses of the three groups during the screening, lead-in, and after 12-week treatments periods (P>0.05). One case of abdominal distension and one case of diarrhea occurred in the Ins+Met group, and the Ins+SZ-A group experienced one case of abdominal distension and no cases of diarrhea. The patients who experienced these events received appropriate medications administered during mealtimes, starting with low doses that were then gradually increased until the adverse reactions were ameliorated, without altering their main treatment regimens.