Abbreviation:
knee arthroplasty
blood loss volumedeep venous thrombosishemoglobinhidden blood lossHospital for Special Surgerynormal salinepostoperative drainage volumepostoperative length of staypostoperative dayrange of motionsurgical site infectiontotal blood losstotal knee arthroplastytranexamic acidvisual analogue scaleXH and FL contributed equally to this work.Clinical trial was registered in the Chinese Clinical Trial Registry (ChiCTR2300071161).This research was supported by Research Project of Guangxi Health Commission (Z20170346 and Z2016597), Science and Technology Plan Project of Guangxi (AB16380230), and Research and Development Project of Suitable Medical Technology of Guangxi (S201544).This study was approved by the Medical Ethics Committee (the Ethics Approval acceptance numbe:KY-ZC-2017-01) and an informed consent was obtained from our responsible Investigational Ethics Review Board.The authors have no conflicts of interest to disclose.The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.How to cite this article: Huang X, Li F, Shi W, Liu W, Huang W, Yin D. Efficacy of perioperative cryotherapy combined with intra-articular injection of tranexamic acid in total knee arthroplasty. Medicine 2023;102:29(e34381).