Author contributions
SB, AH, ST, JH, MN, and RD designed the clinical study. SB, AH, ST, and JH conducted the clinical study and VV, MN, and RD supervised the analysis. AL and EC designed the gut microbiota study. AR-G, AL performed the bioinformatic and statistical analysis and EC supervised the analysis. SB, AH, ST, JH, VV, AR-G, AL wrote the first draft with inputs from EC, VV, MN, and RD. All authors were involved in data interpretation and discussion of the results. All authors contributed to the article and approved the submitted version.