Participants
We calculated the sample size based on previous recommendationsTo ensure an adequate sample size in case participants dropped out, we added 4 more participants to attain the total number of 36 participants. Healthy volunteers interested in participating in the study were screened according to the inclusion and exclusion criteria described on ClinicalTrials.gov (NCT05358873).All volunteers were randomly assigned in a 1:3 ratio into 2 groups: placebo (n = 9) and NAS (n = 27), as shown in Fig. 