Population pharmacokinetic model
Cisplatin data (i.e., ultrafiltered peritoneal and plasma concentrations, and plasma protein bound concentrations obtained by difference between total and ultrafiltered plasma concentrations) were analyzed simultaneously by non-linear mixed effects modeling with NONMEM version 7.4.1 (ICON Development Solutions, Ellicott City, MD, USA) using PiranaArea-under-the-curve of ultrafiltered cisplatin plasma concentrations versus time from 0 to 24 h (AUC