Conclusions
pleural infections
PLEURAL INFECTION
In this pilot randomized clinical trial, we identified an algorithm comparing tissue plasminogen activator plus deoxyribonuclease therapy with surgical decortication to be feasible with 100% enrollment to completion, with excellent multidisciplinary participation and adherence. These findings show that the studied algorithm is safe and efficacious for patients with complicated pleural infections, with a strong feasibility for appropriate enrollment within a reasonable time frame for a multicenter study.