2.1. Trial Design
This is a single-center, assessor-blinded randomized controlled (1:1) superiority trial (RCT) with a parallel-group design. The study was conducted at the department of Pulmonology and the department of Internal Medicine at Maastricht University Medical Centre (MUMC+) in Maastricht, The Netherlands, between March 2021 and January 2022. The study was performed in compliance with the Declaration of Helsinki and was approved by the Medical Ethics Committee of the University Hospital Maastricht and Maastricht University (METC20–083). The study is registered at 