Biomarker analyses
tumor
CPS, TUMOR, TUMOR STROMAL, SOLID TUMORS
PD-L1 expression in pretreatment biopsies was measured in 34 patients. Four of 11 pCR and four of 23 non-pCR patients had a CPS of ≥ 1. No significant difference in PD-L1 expression was found between the pCR and non-pCR cases (TMB is a biomarker for immunotherapy efficacy in multiple solid tumors. A total of 30 cases had adequate pretreatment specimens for NGS. We observed an average of 4.136 ± 1.431 mutations per patient. The most frequent driver mutations were Annotated tissue specimens collected from 40 patients before neoadjuvant treatment and during surgery were subjected to multiplex immunofluorescence to get a glimpse of their TIME. Depending on sample quality, the TIME of tumor center and tumor stromal area in the pretreatment was analyzed in 35 and 40 patients, respectively. The densities of CD8