Statistical Analysis
RA
AUTOIMMUNE DISEASES
A sample size of 2200 patients was calculated to provide 90% power to detect a difference between the SSDM group and the control group at a 2-sided α level of .05, assuming that the 6-month rate of patients with a DAS28-CRP of 3.2 or less was 52.0% in the SSDM group and 44.3% in the control group, allowing for a 20% attrition rate.All end points were analyzed in a modified intent-to-treat (ITT) population that excluded patients with incorrect diagnoses (autoimmune diseases other than RA) upon enrollment. The missing values were imputed using multiple imputation by chained equations (mice) in R (eMethods in 