2.2. Inclusion and Exclusion Criteria
myocardial infarction, seizures, neoplasia, anemia, hematological disorders, milk thistle, asthma, unstable medical illness, DSM-5
MYOCARDIAL INFARCTION, COAGULOPATHIES, NEOPLASIA, ANEMIA, HEMATOLOGICAL DISORDERS, ASTHMA
Inclusion criteria included the following: (a) children and adolescents of both sexes between ages 4–17; (b) diagnosis of ASD as determined by criteria set forth in DSM-5 (Exclusion criteria included the following: (a) unstable medical illness or clinically significant abnormalities on physical examination; (b) history of seizures; (c) history of hematological disorders such as anemia, coagulopathies, neoplasia; (d) history of myocardial infarction within the last 6 months; (e) current pregnancy, lactation, or inadequate contraception in females of childbearing potential; (f) current or recent (past 3 months) substance use or dependence; (g) illegal substance use within 2 weeks of study initiation; (h) previous treatment with glutathione; (i) current treatment with supplements that interfere with glutathione levels including NAC, milk thistle, vitamin C, vitamin B, grape seed extract, amino acids, or zinc; (j) current treatment with medications with known glutamatergic properties such as dextromethorphan, d-cyloserine, amantadine, memantine, lamotrigine, or riluzole; (k) underlying asthma that may potentiate worsening of respiratory symptoms due to glutathione use.