Participant recruitment and randomisation
diabetes
DIABETES, TYPE 1 DIABETES, RECRUITMENT, DIABETES
HIT4HYPOS was a single-centre, randomised, parallel-group study carried out at Ninewells Hospital, Dundee, UK. Ethical approval was obtained from an independent research ethics committee (18/SS/0160) and the study was registered with the ISRCTN registry (ISRCTN15373978). The study was conducted in accordance with the Declaration of Helsinki, and written informed consent was obtained from all participants before inclusion in the study.Eligible participants were aged 18–55 years with type 1 diabetes of at least 5 years’ duration and HbAUsing a web-based system, participants were randomly allocated to real-time continuous glucose monitoring (RT-CGM) or RT-CGM+HIIT. The allocation sequence was generated by an individual not otherwise involved in participant recruitment.Participants were identified using the Scottish Diabetes Research Network (SDRN) and from diabetes outpatient clinics in NHS Tayside, UK. The study took place at the Clinical Research Centre, Ninewells Hospital and Medical School, Dundee. All people who met the study criteria were offered the chance to participate in the study.After obtaining informed written consent and initial screening, participants were randomised to either 4 weeks of RT-CGM or 4 weeks of RT-CGM+HIIT. Participants attended the Clinical Research Centre for eight study visits in total (Fig. Flow diagram of HIT4HYPOS study visits