Authors' contributions
RS
CD (chief investigator), RB (co-investigator), MCH (trial manager), EH (statistician), DP (CTRU lead), NT (statistician) and MW (co-investigator) together produced the first draft of the manuscript. All members of the authorship group, provided in Conceived of or designed the work: RB, DP, CD, NT, MW, ZM, JC, SoA, SA, MB, JB, JCC, AE, FG, JR, HR, GW, JY, TY on behalf of the MAGIC collaborative.Involved in the acquisition of data for the work: MCH, ES, AL, RS, JH, KH, AT, KM, SW and CD on behalf of the MAGIC collaborative.Involved in the analysis of data: EH, NT, MB, AL, RS, RB, DP, CD, MW, MCH on behalf of the MAGIC collaborative.Responsible for statistical analysis and modelling: EH, NT, MB on behalf of the MAGIC collaborative (Responsible for project level steering, national coordination, and data collection: the trial steering committee and data monitoring and ethics committee.Responsible for ensuring adherence to hospital-level governance protocols and regional data collection: local leads.Revised the work critically for important intellectual content: all authors.Involved in the final approval of the version to be published: all authors.