Introduction
dengue, Dengue
VIRUS, YELLOW FEVER, DENGUE, DISEASE, VECTOR-BORNE DISEASES, DENGUE, DISEASE
Dengue, a disease caused by the dengue flavivirus (DENV), is endemic in 129 countries worldwide, and was named by the World Health Organization (WHO) as one of the top ten threats to human health in 2019 [Yellow fever (YF) virus, the archetypal flavivirus, is closely related to DENV and is predominantly transmitted by While a highly effective vaccine against YF has been available for decades, there remains an unmet need for an effective vaccine against dengue which is suitable for use in individuals without prior exposure to the virus. TAK-003 is a tetravalent dengue vaccine candidate based on a DENV-2 backbone, which was originally designed and constructed by scientists at the Division of Vector-Borne Diseases of the US Centers for Disease Control and Prevention (CDC) [The overlapping geographical distributions of YF and dengue mean that travelers to endemic areas could be offered both vaccines. Concomitant administration increases the likelihood that recipients will receive all the necessary vaccines [The aim of this study was to assess the immunogenicity and safety of TAK-003 and YF-17D administered either concomitantly or sequentially in healthy adults aged 18–60 years living in areas non-endemic for either disease.