Simulation scenarios
The following parameters were varied, in a factorial manner unless otherwise stated:Mean trajectory in those not receiving trial treatment: steady, early, late, intermediate decline (with and without extra random effect; intermediate decline with extra random effect only used with the smaller residual error variance below)Treatment effect: no treatment effect, proportional to time, proportional to control group arm change/delayed declineLength of trial: same length as observational study (both 5 years), different length from observational study (3-year trial)Residual error variance: 