Limitations
fatigue
SECONDARY
Our study has several potential limitations. First, although conducted in a major referral center, this is a single-center study only on the Iranian population with a relatively small sample size, therefore our findings should be regarded as preliminary. Second, due to worldwide COVID-19 vaccination, future candidates for this drug will probably be vaccinated, patients. In addition, at the time this study was conducted most Iranians received COVID-19 vaccination, therefore there was a very small number of patients who weren’t vaccinated. Thus, we only included patients who had received at least 2 doses of the COVID-19 vaccine to remove this disparity. Consequently, the result of our study may not apply to non-vaccinated patients. Finally, patients in the fluvoxamine group, received a fixed dose of 100 mg/day and higher doses may have a different impact on PCS, thus further studies are required to evaluate the optimal dosage of fluvoxamine. We believe our biggest limitation is the small sample size due to our limited budget, which reduced the power of this study to support the suggested hypothesis and make our study a preliminary and pilot study. We should also mention that because the primary outcome of this study was fatigue, it doesn’t have the power to support finding on other neuropsychological symptoms, our secondary outcomes.