Strengths and Limitations
RECRUITMENT, STILL
The main strength was the study design with recruitment from the general population into an RCT, the detailed clinical assessment from baseline, objective VOAll statistical models were corrected for variables known to be connected to hippocampal size such as age [A limitation of the study was the low number of participants in whom we were able to obtain acceptable MRSI data. Still, the final number was similar to the The lack of longitudinal MRSI data is a shortcoming of this study. It is possible differences existed in hippocampal metabolites between groups already at baseline, but given the lack of SEG and CG differences on other variables, this is likely not to be a serious problem. The results at the 3-year timepoint would have been even stronger if repeated at 5 years.