References
low back pain, Oswestry Disability, chronic discogenic low back pain, pain, GMH, LBP
ADVERSE EVENT, DISC DEGENERATION
(Changes in pain levels measured using the Visual Analog Scale (VAS) (Tornado plots to visualize the reduction rates in Visual Analog Scale (VAS) (Assessment of disc degeneration grade based on the evaluation of sagittal and axial T2-weighted images. Red triangle indicates the treated L4-5 disc. Yellow triangle indicates disc herniation.Patient characteristics and characterization of cell products.M: male; F: female; BMI: body mass index; Y: yes; N: No; LBP: low back pain; VAS: visual analogue scale; ODI: Oswestry Disability Index.VAS and ODI outcomes according to time points.VAS: visual analogue scale; ODI: Oswestry Disability Index; Pre: Pre-treatment; W: week; M: month.Percentage VAS pain score and ODI score reduction from baseline.VAS: visual analogue scale; ODI: Oswestry Disability Index; W: week; M: month; minus (−): Increase.Radiological outcomes according to time points.Clinical trials using mesenchymal stem cells for chronic discogenic low back pain.FU: follow-up; M: months; No: number; ASC: adipose-derived mesenchymal stem cell; BM-MSC: bone marrow-derived mesenchymal stem cell; MPC: mesenchymal precursor cell; HA: hyaluronic acid; VAS: visual analogue scale; ODI: Oswestry Disability Index; SF: Short Form; MRI: magnetic resonance imaging; EQ-5D-3L: EuroQOL 5-Dimensional Questionnaire; QoL: quality of life; FRI:functional rating index; JOA: Japanese Orthopedic Association score; NPS:numeric pain score (0–10, 0 = no pain, 10 = worst possible pain); GMH: Global Mental Health; GPH: Global Physical Health.Assessment schedule.SV: screen visit; NA: not applicable; V: visit; VAS: visual analogue scale; ODI: Oswestry Disability Index; MRI: magnetic resonance imaging; AE: adverse event; SAE: severe adverse event.Inclusion and exclusion criteria.LBP: low back pain; IVD: intervertebral disc; MRI: magnetic resonance imaging.