Materials and methods
The experiment took place between March 1 and December 20, 2020, at a research lab in the Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden. Ethics approval was obtained from the Swedish Ethical Review Authority (Dnr: 2019/05785), and the project followed the principles for medical research according to the declaration of Helsinki, as well as Good Clinical Practice (GCP) guidelines. Furthermore, the study was registered on ClinicalTrials.gov (Identifier: NCT05378984). The participants received both written and verbal information and gave their verbal and written consent.