Author contributions
JMB, NH, DSM, MR and AG analyzed and interpreted the clinical and translational data. JMB, CV, NH, BV, JMT, GG, AI, JL, CS, JYB, EF and VMM participated in patient enrollment and clinical data collection. MM, RL, MR, DSM, MMR, JALG, JC, and AFS participated in translational research experiments and patient screening. AV, PDT, FLL, RGC and RR, and DHJ were in charge of pathological and radiological central review, respectively. JMB wrote the manuscript. All authors read and approved the final manuscript.