Introduction
cancers, malignancy, cancer, dysbiosis, deaths
CANCER, CANCERS, PROLIFERATIVE, BREAST CANCER
The most frequent malignancy among women all around the world is breast cancer( BC) with about 2 million diagnosed cases and 0.6 million deaths in 2020 [Chemotherapy is the main treatment in most patients with breast cancer. Cytotoxic agents damage and kill cancer cells through destroying DNA structure and stimulating apoptotic pathways; however, it can inevitably harm normal tissues, especially high proliferative ones, like the intestinal epithelial cells. Thus, chemotherapy often causes annoying side effects that may reduce the quality of a patient’s life [Anti-cancerous properties of probiotics, the live and beneficial microorganisms, marketed as food or supplements, have been frequently reviewed in previous studies. These properties can be reached by shifting the induced dysbiosis to eubiosis and homeostasis of microflora, and following advantages of normalizing cellular processes, metabolism, physiological pathways, and immunity [Synbiotics, a combination of probiotic bacteria and polysaccharide as prebiotics, are less considered as adjuvant therapy in cancer cases, especially in cancers indirectly related to intestinal flora [