Mixed‐effect model for repeated measure
TSS
The longitudinal MMRM model was used to evaluate the adjusted treatment group mean differences in SIMPLIFY‐1 and SIMPLIFY‐2. The differences in mean change of MPN‐SAF TSS from baseline across each planned assessment (i.e., every‐4 week interval up to Week 24) were tested using an MMRM model with treatment, time, treatment‐by‐time interaction, age, race, and baseline MPN‐SAF TSS included as fixed and random covariates. The restricted maximum likelihood estimation was implemented with an unstructured covariance matrix shared across treatment groups for modeling the within‐patient errors.Least squares (LS) means, corresponding standard errors, and 95% two‐sided CIs were determined for the within‐group change for all time points. For the between‐treatment group comparison, the difference in LS means, corresponding standard errors, 95% two‐sided CI, and 