Introduction
respiratory disease, death, dyspnea, COPD
RESPIRATORY DISEASE, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, DISEASE, COPD, OXIDATIVE STRESS, PATHOGENESIS
Chronic obstructive pulmonary disease (COPD) is a common progressive respiratory disease characterized by persistent airflow restriction, and is a significant cause of disease death worldwide [Pulmonary rehabilitation is an individualized treatment strategy, which aims to improve the physical and psychological conditions of COPD patients and promote their long-term healthy behaviors through exercise training, self-control management and behavioral intervention [The imbalance of oxidation/antioxidant system is one of driving mechanism in pathogenesis of COPD. For decades, there were a great number of reports confirmed that enhancing endogenous antioxidant stress is an effective strategy for treating COPD [In the present work, we aimed to explore the clinical therapeutic effect of sequential NIPPV + IMT in COPD patients and its association with SOCS5/JAK2/STAT3 signaling pathway, as well as the biological roles of SOCS5/JAK2/STAT3 signaling in oxidative stress damage in COPD mice model. Thus, we proposed a hypothesis that sequential NIPPV + IMT might improve exercise tolerance, quality of life, dyspnea and oxidative stress in COPD patients by regulating SOCS5/JAK2/STAT3 signaling pathway.