Supplementary Information
STEMI, ischemia, IRI, reperfusion injury, ST-elevation myocardial
ISCHEMIA
Daytime variation affects the tolerance of cardiomyocytes to ischemia–reperfusion injury (IRI). This study aims to evaluate the impact of time-of-day reperfusion on clinical outcomes of remote ischemic conditioning (RIC) as an adjuvant to primary percutaneous coronary intervention(PPCI) in ST-elevation myocardial infarction(STEMI) patients. A post-hoc analysis of a prospective, single-center parallel 1:1 randomized trial (RIC-STEMI) was performed. This analysis included 448 STEMI patients previously randomized to either PPCI alone (PPCI group) (The online version contains supplementary material available at 10.1007/s00380-023-02247-8.