Introduction
Bladder pain, wasting disease, BPS/IC
AUTOIMMUNE RESPONSE, DISEASE, WASTING DISEASE, PATHOGENESIS, CYSTITIS
Bladder pain syndrome/interstitial cystitis (BPS/IC) is a chronic progressive wasting disease with multiple causes and a long course of development. The disease currently lacks a recognized definition and a clear diagnostic criteria. At present, the pathogenesis of BPS/IC is not yet clear, and it may be closely related to many pathological and physiological changes, including changes in bladder mucosal tissue, mast cell activation, autoimmune response, changes in peripheral and central nervous system nociceptors, etc. [