Randomization
aggression
Block randomization was used with a block size of 8 participants at a 1: 1 ratio through a computerised random number generator. Four strata were made according to age (i.e., younger than 18 or 18 and older) and aggression score in the preceding week (low aggression [SDAS <18] or high aggression [SDAS ≥18]). The allocation was managed by an independent LUMC research pharmacist and only released upon completion of the statistical analysis on the primary outcome.