Randomization and blinding
tinnitus
TINNITUS
Eligible participants are randomly allocated to one of ten treatment arms of single or combinational treatments (see Fig. Randomization scheme as shown in the study protocol. Figure reproduced from [Table Expected randomization per center and per treatmentThe randomization of patients takes place at each clinical site and is monitored centrally. A specific interactive web response system (IWRS) is used to support each clinical site with the randomization of their patients. This facilitates the management of many patients from different sites located in several countries and the monitoring of the multicentric study with a complex design. The distribution across the four strata is centrally monitored during the randomization process. If a recruited and eligible participant quits the RCT participation before randomization, this participant is considered a screening failure. In case an eligible participant is already randomized to a treatment group and quits study participation, this patient is considered a dropout.The local clinical staff will enter clinical data into a central tinnitus database [