Trial design, settings, and location of data collection
This was a double-blind (patient and examiner), split-mouth, prospective, and randomized clinical trial. This study was conducted at the clinics of the School of Fluminense Federal University, Nova Friburgo, RJ, Brazil, from August 17, 2017, to September 30, 2017. The 24-month follow-up evaluation was conducted from August, 2019 to September, 2019.