Methods in analysis to handle protocol non-adherence and any statistical methods to handle missing data {20c}
Missing datasets due to participants’ withdrawal from the trial will not be imputed. However, if two of the three study datasets are complete (especially if the control condition is available), these can still be used for two-sided study arm comparisons.Missing data in metabolic feature tables are common. Typical imputation strategies (e.g., gap filling) in the field of metabolomics are already incorporated in raw data processing software. Therefore, processing parameters will be reported in detail.