Funding
This study was supported by Grants by Genentech, Inc. (A.S.P., E.M., J.H., B.J.M., L.G.); National Institutes of Health [Grants R01 HL111024, R01 HL135142 and R01 HL1130974] (G.M.H.); National Center for Advancing Translational Sciences, National Institutes of Health [Grant UL1TR002544]. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. Genentech had no role in the design of the study, the collection and analysis of the data, or the preparation of the manuscript.