Trial oversight
The study was conducted in accordance with local laws, the International Conference on harmonisation Good Clinical Practice guidelines, and the ethical principles outlined in the Declaration of Helsinki. The study protocol and informed consent form were approved by ethics committees of all study sites: Peking University People’s Hospital; The First Affiliated Hospital and Clinical Medicine College of Henan University of Science and Technology; The Fourth Affiliated Hospital of Harbin Medical University; Huzhou Central Hospital; Shandong Province Qianfoshan Hospital; Pingxiang People’ s Hospital; The First Affiliated Hospital of Bengbu Medical College; Jinan Central Hospital; The Second Hospital of Hebei Medical University; Chu Hsien-I Memorial Hospital; Jiangsu Province Hospital; Sun Yat-Sen Memorial Hospital; Shanghai Tenth People’s Hospital of Tong Ji University; Qilu Hospital of Shandong University; Inner Mongolia Autonomous Region People’s Hospital; Luoyang Central Hospital; Tonghua Central Hospital; Jingzhou Central Hospital; The First Affiliated Hospital of Nanyang Medical College. All participants provided written informed consent before study entry, between June 11, 2021 and Oct. 1, 2021.