Statistical analysis
Demographic and clinical features were displayed using standard descriptive statistics including mean ± S.D, median (interquartile range), or number (percentage) where appropriate. Repeated measures mixed models were used for the urine pH and sUA analysis in the per-protocol (PP) population. A Bonferroni correction was used among 3 treatment comparisons at an alpha level of 0.016. The comparison of response rates based on the distribution of urine pH and sUA levels was calculated by chi-square test among the three groups. The changes in UACR were analyzed by a generalized estimation equation model with baseline values as covariates. Comparisons before and after treatment within the group were made using paired 