Design
SE
A multicentre, prospective and non-blinded RCT was conducted to compare the efficacy and safety of intravenous LEV and intravenous FPHT for the treatment of adult SE in the emergency room. The primary aim of the present study was to examine the non-inferiority of the efficacy of LEV to that of FPHT as a second-line treatment for SE after the administration of diazepam. The present study was conducted as a Japanese Association for Acute Medicine initiative study. It was registered at the Japan Registry of Clinical Trials (