Outcomes and analysis
SECONDARY
The primary endpoint of the study, PrEP initiation, was defined as PrEP dispensation at enrolment. With 330 participants, the study had 80% power to detect ≥15% difference in PrEP initiation, assuming initiation by 60% in the control group and 75% in the DST group. The secondary endpoint, PrEP persistence at month 1 among those initiating PrEP, was selected due to high (40%–66%) early PrEP discontinuation rates observed in African young women [