Statistical Analysis
REGRESSION, SECONDARY, RECRUITMENT
The original intended sample size of 360 was revised to 200 due to recruitment limitations in the context of the COVID-19 pandemic. A sample size of 200 participants (100 participants per group) was calculated to have 90% power (2-sided, type 1 error 5) to detect a difference in 90-day JAFKQ score of 8.95%. This calculation allowed for 15% attrition and assumed an SD of 18, as previously observed.Due to the nature of the JAFKQ displaying a different number of questions depending on anticoagulant prescription, the primary outcome was analyzed in a log binomial logistic regression model. Age, sex, education, subtype of AF, and baseline JAFKQ score were included as covariates, due to a possible impact on AF knowledge. Resultant odds ratios (ORs) accompanied by 95% CIs describe the odds of a correct JAFKQ answer in intervention compared with control participants. The significance of difference between proportional secondary outcomes (satisfaction with care, education, motivation to maintain medication adherence, and reported medication adherence) was analyzed in a log binomial model adjusting for age, sex, education, subtype of AF, and baseline score where available. All analyses were completed according to principles of intention to treat. An as-treated analysis examining primary and secondary outcomes among highly engaged (watched videos on ≥3 additional occasions), moderately engaged (watched videos on 1-2 additional occasions) and poorly engaged (watched videos on 0 further occasions) participants was also conducted.Analyses were conducted using R statistical software version 4.1.2 (R Project for Statistical Computing). 