Trial design
This study was a 12-week double-blind parallel randomized placebo-controlled trial with a 3-week run-in period. It was conducted in agreement with the Declaration of Helsinki and its later amendments. Eligible patients were recruited from Fars MS Association and Imam Reza (A.S) Clinic located in Shiraz, Iran. Before the enrollment, informed consent was obtained from the participants. This trial was approved by the Medical Ethics Committee at the Isfahan University of Medical Sciences under the ethics code IR.MUI.RESEARCH.REC.1400.248. Also, it was prospectively registered at the Iranian Registry of Clinical Trials (