Background
malaria, infection
MALARIA, INFECTION
Globally, progress against malaria morbidity has stalled, with the remaining burden concentrated in eleven countries, including Uganda [While vector control remains the primary way to reduce malaria burden and transmission, chemoprevention may also have a role in high burden regions where progress has faltered [MDA is a full course of an antimalarial treatment given to the whole population in a given area at approximately the same time, irrespective of symptoms or infection status and with the exception of individuals for whom the medicine is contraindicated [Absent of concurrent vector control, the duration of MDA impact on parasite prevalence in a high transmission setting is expected to be limited; rebound is predicted to occur rapidly after a transient period of chemoprophylactic prevention [The synchronous application of MDA and vector control could increase the impact of MDA on prevalence. Prior work noted a robust impact of combining MDA with vector control, showing the strategy effective for burden reduction in high transmission regions, though not for achieving complete elimination [Because an MDA campaign initially removes so much infection in high transmission, the cooperative advantage is predicted to increase with transmission intensity, making the strategy of particular interest in high burden settings [