Introduction
tumor necrosis, chronic systemic disease, inflammation, arthritis, gout, Gout, monoarthritis, gouty arthritis
TUMOR NECROSIS, INFLAMMATION, GOUT, ARTHRITIS, GOUT, MONOARTHRITIS, GOUTY ARTHRITIS, ACUTE GOUT
Gout is a chronic systemic disease that features intermittent monoarthritis in different joints including the first metatarsal joint, tarsal joint, ankle, knee, and wrist. Most patients with gout may not take regular medication for its control; thus, intermittent arthritis attacks result. Except during recurrent arthritis episodes, systemic inflammation may develop during the progression of gouty arthritis (GA). Elevations in serum acute phase proteins, including C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), occur in patients with acute gout flare. Increased expression of different inflammatory cytokines, such as interleukin (IL)-6, IL-1, and tumor necrosis factor-α, are observed during acute gout attacks [