Mass spectrometric conditions
HEAT
The MS system, coupled with a (-)ESI ion source, was used in this analytical method due to the significant intensity observed in the negative ionization. The MS quantification was obtained by monitoring precursor/product ion transitions (m/z) at 349.1/287.2, 331.1/239.2, 479.2/161.0, 333.1/285.2 and 779.3/649.2 for AP1, AP3, AP4, AP6, and IS, respectively (Table In summary, the instrument settings for MS analyses were as follows: nebulizer gas flow = 3 L/min, heating gas flow = 10 L/min, drying gas flow = 10 L/min, interface temperature = 150 °C, heat block temperature = 250 °C, and DL temperature = 200 °C.