Participants
myofascial pain, mental illness, Orofacial Pain, TMD pain, TMD, odontogenic, muscle contraction, inflammation, rheumatic, whiplash injury, pain, NRS
MYOFASCIAL PAIN, SYSTEMIC DISEASE, IMPACTED MOLARS, INFLAMMATION, DISEASE, DISORDERS, METABOLIC DISEASES, CAVITY
The study included 104 women aged 20 to 45 years who, based on DC/TMD criteria, were diagnosed with myofascial pain with mouth opening restriction, for longer than 3 months (Ib). Patients were randomly assigned (simple randomization) to the experimental four therapeutic group i.e.: magnetostimulation (MS, n = 26), magnetoledotherapy (MLE, n = 26), magnetolaserotherapy (MLA, n = 26), manual therapy (MT, n = 26). None of the respondents refused to participate in the study.Study exclusion criteria were as follows: inflammation in the oral cavity that emerged as myospasm or preventive muscle contraction, earlier splint therapy, pharmacotherapy (e.g., oral contraception, hormone replacement therapy, and antidepressants), systemic diseases (e.g., rheumatic and metabolic diseases), mental illness, lack of mandible orthopedic stability, masticatory organ or whiplash injury, pregnancy, patients undergoing orthodontic treatment, other types of inflammation in the oral cavity (e.g., pulp inflammation or impacted molars), and fibromyalgia;dermatology disease, contraindications to the use of physical treatments in the field of magneto-stimulation, light therapy or manual therapy.All women underwent an intra-oral and extra-oral dental examination performed by an Orofacial Pain trained dentist. The aim was to exclude odontogenic, periodontal and intracapsular origins of TMD pain.The control group (G2) consisted of 104 healthy women, aged 20 to 45, without claimed TMD and pain disorders (intra-oral and extra-oral dental examination).The determination of whether the patient met the inclusion criteria on the basis of the subject and physical examination was made by a dentist. Afterwards, another dentist participated to randomize the patients.The patients qualified for the study underwent instrumental diagnostics (sEMG of the masseter muscles at rest and exercise, linear measurement of the range of mandibular mobility) and the level of pain intensity was assessed on the NRS numerical scale. Then, in G1, ROM and NRS measurements were performed each time after treatment, and sEMG after 5 and 10 days of treatment.The study was conducted from January 2022 to February 2023 on patients of the University Dental Clinic of the Pomeranian Medical University in Szczecin.The activities undertaken by the investigators during the trial are presented in Table 
Activities of investigators during the trialLegend: 0 - preliminary examination, 10 – the last day of therapy and final examination