Dose response
BEST
Mean administered activity of radium-223 in kBq per cycle was not associated with global MRI response (Best percentage change in global apparent diffusion coefficient, by mean activity administered per cycle.On a per-lesion analysis, overall, 134 lesions were assessed in 36 patients; MRI response, defined as a 30% increase in mean apparent diffusion coefficient, was seen in 55% (73/134) of patients (Best percentage change in individual lesion apparent diffusion coefficient, by mean activity administered per cycle.