Introduction
Hypothermia, brain insult, TBI, traumatic brain injury
HEAT, BRAIN, PATHOPHYSIOLOGY
The heterogeneity of brain insult and systemic instability make understanding the pathophysiology of severe traumatic brain injury (TBI) extremely difficult. Using our data from the Brain Hypothermia Study (B-HYPO Study) in Japan [Monitoring the core body temperature as measured in the brain, jugular bulb, pulmonary artery, tympanic membrane, bladder, or rectum, is essential in patients with severe TBI. Brain temperature depends on three main factors: regional brain heat production, cerebral blood flow, and the temperature of arterial blood in the brain [We hypothesized that these core temperatures and the difference between them (ΔT