Effect of UP165 on salivary cortisol level
CORTEX
Cortisol, one of the major glucocorticoid hormones secreted by the adrenal cortex, is among the hormones that regulate human sleep, with its increase being associated with poor sleep quality. In this clinical study, subjects supplemented with UP165 showed a progressive decrease in salivary cortisol level through the course of the study (Percentage changes of salivary cortisol levels from supplements of three test articles. The study enrolled 45 volunteers to participate in a 6-week trial. Participants (age range 19–73) consumed the supplement or placebo ∼60 minutes before bedtime daily for 4 weeks after a 2-week baseline period (no supplementation). The active test material UP165 was administered orally at 250 and 500 mg/day. *Effect of UP165 on Salivary Cortisol LevelThe study enrolled 45 volunteers to participate in a 6-week trial. Participants (age range 19–73) consumed the supplement or placebo ∼60 minutes before bedtime daily for 4 weeks after a 2-week baseline period (no supplementation). Data in parenthesis are Interestingly, as shown in Reductions of cortisol level such as 11.0%, 21.8%, 20.2%, and 27.5% for the 250 mg/day and 15.0%, 18.2%, 29.5%, and 36.3% for the 500 mg/day UP165 were observed for weeks 1–4, respectively. In contrast, 6.2%, 9.8%, 1.7%, and 3.4% increase in the salivary cortisol level was observed for the placebo group for the same time frame. These cortisol findings align well with the deep sleep findings described above, affirming the improved sleep quality and efficiency experienced as a result of UP165 supplementation.