Author contributions
M.P. and J.C. were lead investigators. M.P., J.M.M. and J.C contributed to study design and development of concept. S.G., M.P. and J.C drafted the manuscript. N.P. and C.T performed statistical analysis. M.P. obtained funding. S.V., P.H., G.H., D.M., M.S., S.G., M.P., J.C., N.P. and C.T. had full access to all data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. The SAFO study group contributed to data acquisition and critical revision of the manuscript. All authors contributed to acquisition, analysis or interpretation of data, and performed critical revision of the manuscript for important intellectual content.