Author contributions
RECRUITMENT
F.G. was the coordinating investigator of the study and was responsible for study conception and design and acquisition of funding and approvals. He also contributed as an investigator and medical monitor and to patient recruitment, data collection and data interpretation. The paper was written by F.G., M.T. and C.T., with contributions from all authors. J.-D.F., B.C., J.B., C.B., J.M.-B., R.C., M.F. and J.T. were investigators for the other sites and contributed to patient recruitment and data acquisition. A.B. and J.B. performed the clinical statistical analyses. C.T., E.B., H.M. and M.P. performed all the bioinformatics analyses (related to exome, RNA-seq and flow cytometry). R.B. was in charge of performing exomes and RNA-seq. V.D. carried out the immunohistological staining. C.L. and O.A. assessed the ELISpot assays. H.A.M. supervised the mass cytometry experiments. M.T. was responsible for the biological collection and ancillary studies. L.H., M.B. and S.D. performed translational laboratory analyses. All authors approved the final version of the paper.