Introduction
Liver cancer, cancer, death, HCC
LIVER CANCER, CANCER, HEPATOCELLULAR CARCINOMA, OF PRIMARY LIVER CANCER
Liver cancer is the sixth most commonly diagnosed cancer and the third leading cancer-related cause of death worldwide, and among the different forms of primary liver cancers, hepatocellular carcinoma (HCC) is the most common, accounting for 75% to 90% of cases.Antidepressants are commonly used drugs that have potential anticancer effects.Therefore, we conducted a national cohort study to examine the association between antidepressants and HCC prognosis. We investigated overall and cancer-specific mortality as HCC prognosis indices. To examine whether the timing of antidepressant use influenced the association with HCC prognosis, we distinguished between antidepressant use before and after HCC diagnosis.