Discussion
infected droplets, gingivitis
GINGIVITIS, CAVITY, DENTAL PLAQUE, PLAQUE
Covid-19 is known to transfer from one person to another through infected droplets and aerosols. Close contact of dentists with patients and aerosol-generating procedures can significantly increase airborne contamination and cross-infection of SARS-CoV-2 in dental clinics.Antiseptic mouthrinses have been suggested for various prophylactic and therapeutic purposes in dentistry. However, their anti-SARS-CoV-2 effect to control the viral load has not been evaluated systematically.Mouthwashes should have a high substantivity. It means that they are released slowly, so they show their antimicrobial effects for an extended time; therefore, only mouthrinses with high substantivity may be effective against Covid-19.In-vitro studies demonstrated that different concentrations of povidone-iodine have antiviral effects against SARSCOV-2 [Hydrogen peroxide eliminates microorganisms of the oral cavity by degradation into oxygen and water. Hossainian et al. found that hydrogen peroxide mouthwashes did not consistently control the microbiota of the oral cavity [PVP-I is a water-soluble iodophor composed of iodine and polyvinylpyrrolidone as a water-soluble polymer [CHX is a broad-spectrum antiseptic mouthwash with antibacterial and antiplaque properties [Listerine mouthrinses contain four active ingredients (eucalyptol, menthol, methyl salicylate, thymol) as well as inactive constituents such as water, alcohol and benzoic acid. Previous studies demonstrated the effectiveness of Listerine in reducing dental plaque and gingivitis [CDCM mouthwash contains beta-cyclodextrin and Citrox. A study by Carrouel et al. that evaluated this compound was included in the present systematic review and meta-analysis. Hooper et al. found that 1% CDCM mouthwash significantly inhibited the growth of 14 bacterial and some candida species [CPC is a quaternary ammonium water-soluble compound. CPC can penetrate the cell membrane, raise the endocytic and lysosomal PH, and disrupt the cell activity. In past decades, some clinical trials showed that CPC mouthwashes were effective in gingivitis and plaque control [A limited number of clinical trial studies examined the effect of mouthwashes on the viral load of Covid-19 in the saliva. The sample size of some of these experimental studies was small. Therefore, more clinical trial studies with standard sample sizes are required.