Intervention
DEL
The participants that met the inclusion criteria were administered four chewable tablets with the same size, color, and shape of either active product or placebo 90 min before the neuropsychological test. The participants were asked to dissolve the tablets in the mouth (to favor the contact with the salivary microbiome) and to swallow saliva as many times as possible. The BR-based chewable tablets (BR-CT) contained 3 g of a The placebo contained maltodextrin instead of the active components and had the same shape, color, and taste. The participants were requested to avoid food, not to rinse the mouth, not to engage in strenuous physical activity in the 2-h period before taking the chewable tablets, and to avoid stimulating substances (i.e., caffeine or theophylline) 6 h prior to the intervention. The formulations were produced by Laboratori Plants Group (Pace del Mela ME, Italy).