Statistical analysis
Continuous variables are presented as mean with standard deviation (SD) or median with interquartile range (IQR) depending on distribution of the variable. Categorical variables are presented as counts and percentiles. The within group change was calculated as follow-up minus baseline and presented as median. The change difference was calculated as control minus intervention. Changes from baseline to follow-up between intervention and standard care group were tested using the Wilcoxon rank-sum test because the normality assumption of the distribution could not be satisfied. The normality assumption was evaluated using QQ plots and histograms.Given that the intervention is offered to the patients depending on their needs in order to mirror clinical practice, the analysis is considered intention to treat (ITT).To account for possible differences in baseline values between groups (see the Missing data were considered missing at random. No further imputation of missing values was made. Statistical significance was defined as a p-value below 0.05. All analyses were conducted using R version 3.6.1 [