ITT analysis of the outcomes.
HYPOTHYROIDISM
1: within group comparison, paired t-test, 2: between group comparison, independent t-test, 3: two-way ANCOVA analysis with adjustment for duration of hypothyroidism, age, levothyroxine dose, and physical activity.(DOCX)Click here for additional data file.(DOCX)Click here for additional data file.We would like to thank the endocrine clinic of Baqiyatallah Hospital for providing required arrangements and facilities for this research, and “Zist-Takhmir” pharmaceutical company for providing synbiotic and placebo capsules. We also appreciate the cooperation of all the participants of this study.