Conclusions
RECRUITMENT
Increasing recruitment from underrepresented groups is an important problem to address for RCTs. This was innovatively accomplished without the need for local site involvement. The pragmatic approach is a relatively new concept in the conduct of RCTs. Importantly, our step-by-step approach and detailed workflows provides an easy-to-follow blueprint for others seeking to implement point of care studies in the context of usual clinical care.While an EHR-based pragmatic approach has important advantages over a traditional study design for patient recruitment, successful implementation and conduct are contingent on the technical expertise of team members and ongoing support from information services. However, we believe that the potential challenges encountered by health care systems to implement a pragmatic approach in the short run will be off set as newer technologies arise (eg, artificial intelligence, machine learning, and natural language processing).