Conclusion
PDDE
LUNG INFLAMMATION, RECRUITMENT
In summary, leveraging a controlled co-exposure to common environmental pollutants and allergens, we assessed the effect of a GRS related to lung inflammation in response to allergen and DE on lung function and cellular recruitment. We determined that increasing GRS was associated with increased AHR and macrophage recruitment when exposed to FA or PDDE and allergen. However, co-exposure to DE and allergen showed no change in AHR or immune cell recruitment and was associated with a decrease in specific immune mediators at 48 h. We theorized that 