Kaplan-Meier curves representing time-to-death and survival data in 
bacteremia, death, toxemia
RECURRENCE, TOXEMIA
Kaplan-Meier curves for survival and time to death in nonhuman primates. Analysis of survival rates in the context of toxemia suggests that lower survival rates at lower ANTHRASIL doses correspond to the recurrence of toxemia and bacteremia after initial resolution. Despite a clear decrease in the incidence of toxemia recurrence with increasing doses of ANTHRASIL, no definitive conclusion regarding toxemia recurrence and its relationship with mortality could be made because the majority of animals succumbed from 72 h to Day 7 PoC when there was no toxemia analysis. Although all animals were toxemic prior to treatment, some animals were not bacteremic prior to treatment. Therefore, survival was separately assessed in animals that were bacteremic prior to treatment. Survival rates in this subset of animals were 0%, 36%, 43% and 70% in the Placebo, 7.5 U/kg, 15 U/kg, and 30 U/kg-ANTHRASIL-treated groups, respectively. These survival rates were significantly greater in the 7.5 U/kg, 15 U/kg, and 30 U/kg-ANTHRASIL-treated groups compared to controls (p ≤ 0.0451) (