Introduction
kidney injury, acute kidney injury
Iodinated contrast materials are commonly used in the urology daily practice. It can be used for intravenous contrasted imaging studies ranging from intravenous pyelogram, contrast enhanced computed tomography (CECT) up to diagnostic and intervention angiography. However, the iodinated contrast has been involved in many cases of kidney injury [The definition, incidence, and risks of post-contrast acute kidney injury (PC-AKI) have not been clearly defined [The Contrast Media Safety Committee of ESUR highly recommend volume expansion with plenty of intravenous fluid over oral hydration [Several medications have been advised to obviate PC-AKI. Some of them showed conflicting results regarding PC-AKI prevention such as; calcium channel blockers, mannitol, dopamine, atrial natriuretic peptide, L-arginine, selective D1 receptor partial agonist known as fenoldopam, prostaglandin E1, loop diuretic as furosemide, and endothelin receptor antagonist [For patients undergoing computed tomography (CT) with a nonionic, low-osmolality contrast agent, A lot of studies try to investigate medications for prevention of PC-AKI in cardiac and vascular patients. On the other hand, sparse of them investigate those medications in the field of urology [In this trial, we will try to investigate the combined use of both ascorbic acid and statin for patients undergoing urologic diagnostic contrast enhanced CT and their effect of kidney injury caused by CECT.