Authors’ contributions {31b}
TBC, LLA
TBC
TBC and JFD are the principal investigators of the study. TBC is the clinical coordinator, and JFD coordinates the microbiological part of the study. TBC and JFD have conceived the idea and developed the clinical trial protocol. MGS is responsible for the clinical trial agency at IDIVAL and the SCReN node in Cantabria. LLA is the project manager and coordinates the local monitors belonging to the SCReN network in the participating centers. TBC, JFD, AFM, and LLA wrote the manuscript. All the authors acquired data and read and approved the final manuscript.