Study participants
lumbar spinal stenosis, allergy, cognitive dysfunction, liver and kidney insufficiency, hypoxemia, coagulation abnormalities
ATRIOVENTRICULAR BLOCK, HYPOALBUMINEMIA, LUMBAR SPINAL STENOSIS, ALLERGY, CONGESTIVE HEART FAILURE, CARDIAC DISEASE, GASTROINTESTINAL OBSTRUCTION, COMPLICATIONS
The single-center, double-blind, placebo-controlled randomized clinical trial study enrolled patients who underwent lumbar spinal stenosis surgery from January 1, 2022, to June 30, 2022. This study was approved by the Ethics Committee of Bethune International Peace Hospital (No.2021-KY-165) and registered at the Chinese Clinical Trial Registry (ChiCTR2100054852, 28/12/2021). All participants gave written informed consent. All methods were carried out in accordance with relevant guidelines and regulations, following the Declaration of Helsinki. A total of 66 patients aged 18–75 years old with American Society of Anesthesiologists (ASA) grade I–III were scheduled for open posterior lumbar spinal fusion surgery under general anesthesia. The exclusion criteria included allergy to anesthetic drugs, coagulation abnormalities, preoperative gastrointestinal obstruction, severe cardiac disease, severe sinoatrial node dysfunction(degree II or III atrioventricular block), congestive heart failure, liver and kidney insufficiency or cognitive dysfunction, hypoxemia, hypoalbuminemia, a long history of anti-inflammatory drugs and hormones; The rejection criteria included patients who had serious complications or accidents during perioperative or anesthesia, not cooperating with the questionnaire and those who required admission to the Intensive Care Unit(ICU) after surgery.