Efficacy
PD, death, tumor
DISEASE, TUMOR
All 15 patients were evaluable for response (Patients’ response to olaparibNOTE: PFS defined as the duration of time from start of treatment to time of progression or death, whichever occurs first. OS calculated from initiation of treatment to date of death or last known date of contact. + = alive or lost to follow-up.
In the whole study population, the median PFS was 3.63 months (95% CI, 1.87–5.53; Kaplan–Meier survival curves. We compared PFS and OS of patients with WHO grade 2 or 3 lesions based on archived tissue from diagnosis, to those with grade 4 by histology or CDKN2A alteration. The median PFS of patients with grade 2 and/or 3 was 5.23 months (95% CI, 3.63–9.2) while those with grade 4 was 1.8 months (95% CI, 1.77–NR; log-rank test Reevaluation of imaging of all patients by a blinded NCI-designated neuroradiologist was performed. Two discordant results were identified: one patient's tumor had progressed after six cycles of treatment but was kept on for four additional cycles by the enrolling site. The corrected months of progression-free disease was reported in the above data. The second patient with discordant results had been taken off treatment due to PD after five cycles by their treating physician. However, reassessment of their scans demonstrated SD.