Sensitivity Analysis
primary lesions
The demographic characteristics of the population before and after changing randomization ratios were not significantly different between CRTCT and RT groups, except there were more patients with primary lesions 5 cm or more in length in the CRTCT group (eTable 3 and eTable 4 in In the PP population analysis, the median OS was not reached in CRTCT group, and the median (IQR) OS was 21.2 (14.3-28.0) months in the RT group. The OS rates in the CRTCT group and the RT group were 82.4% vs 63.9% at 1 year, 68.2% vs 45.9% at 2 years, and 56.8% vs 35.7% at 3 years (HR, 0.52; 95% CI, 0.35-0.76; log-rank Among patients who completed concurrent chemotherapy in the CRTCT group, patients who completed consolidation with S-1 attained better survival rates compared with those who discontinued or refused consolidation (3-year OS: 56.8% vs 47.1%; log-rank 