Correlative studies
tumor
TUMOR
Pre- and post-treatment tumor tissue was available from 9 patients. Supplemental Table 5 provides an overall summary of the results for the correlative studies performed to date. Pre- and post-treatment tumor samples from 6 patients were evaluated by Western immunoblots for quantification of the intensities of specific bands for pERK, ERK, pAKT and AKT, and pCRAF and CRAF (See Supplementary Figure 1). Statistically significant ((An example of IHC staining for GRM1, BIM and BCL-2 in a patient who experienced a partial response and clinical benefit is shown in 