Implementation input
DLTs
For implementation, the app relies upon the user specifying the following set of input parameters:Design/protocol informationThe target NCI-CTACE DLT probability (i.e., 0.20).The target PRO-CTACE DLT probability (i.e., 0.55).The variance of the normal prior for the NCI-DLT probability model (i.e., 1.60).The variance of the normal prior for the PRO-DLT probability model (i.e., 1.58).Observed trial data (do not count “replaced” patients). The length of inputs (a)–(d) should be equal to the number of possible study dose levelsThe number of observed NCI-CTCAE DLTs at each dose level. If none have been observed or a dose level has not yet been tried, enter “0”. (i.e., 0.1).The number of patients evaluated for NCI-CTCAE DLT at each dose level. If a dose level has not yet been tried, enter “0”. (i.e., 3.3).The number of observed PRO-CTCAE DLTs at each dose level. If none have been observed or a dose level has not yet been tried, enter “0”. (i.e., 0.2).The number of patients evaluated for PRO-CTCAE DLT at each dose level. If a dose level has not yet been tried, enter “0”. (i.e., 0.3).The most recent dose level administered in the study (i.e., 2).The confidence level for safety stopping rule at the lowest study dose level (i.e., 0.80)The implementation results will be generated by clicking the 