Effect of Exercise (Aerobic-Resistance Training) and Cognitive Intervention and Exercise Alone at 6-Month End Point
Abbreviations: ES, effect size; MD, mean difference.Marginal means and standard errors obtained from linear mixed models are reported for within-group differences.Between-group differences were assessed using the interaction between time × intervention arm. Lower scores indicate cognitive improvement.Inside the table analyses showed a significant ADAS-Cog-13 improvement in arm 1 (exercise, cognitive training, and vitamin D: mean change, −2.64 points; 95% CI, −4.42 to −0.87 points; Clinically significant improvement in ADAS-Cog-13 (3 points or more) was observed for 44% of participants in arm 1, 37% in arm 2, 14% in arm 3, 24% in arm 4, and 15% in arm 5 (eTable 5 in No significant improvement in the ADAS-Cog-Plus scores across the intervention arms compared with the control (arm 5) was identified (