Results
weight gain
HYPOGLYCAEMIA
742 patients were screened between 22 November 2016 and 24 January 2020 and 525 participants randomised to the TriMaster studyAt baseline, when participants were asked their priorities for an additional glucose-lowering therapy they were most likely to rate lower blood glucose level and feeling better as very important issues with possibility of hypoglycaemia, weight gain, and side effects seen as less important (Participant characteristics recorded after receiving each of the drugs are shown in Overall, there was equipoise between the three drugs. There was no overall difference in mean HbA1c, pioglitazone 59.6 (95% CI 58.5,60.7), sitagliptin 60.0 (95% CI 59.0,61.1), canagliflozin 60.6 (95% CI 59.7,61.6)mmol/mol (p=0.2) The lowest mean number of side effects was reported for sitagliptin. Weight was lower when treated with canagliflozin. Pioglitazone was more tolerable, with lower rates of discontinuation. When looking at within participant comparisons of the on-treatment characteristics for the three drugs, more people had their lowest HbA1c on pioglitazone, their lowest number of side effects on sitagliptin, and their lowest weight on canagliflozin (