2.7. Statistical Analysis
SECONDARY
Statistical analyses were conducted per the protocol set. The primary and secondary endpoints, VAS value of discomfort, UWSFR, and salivary IgA secretion rate were analyzed using a linear mixed model in which the treatment, period, and baseline values were fixed effects and participant identity was a variable effect. The analysis was conducted in accordance with a closed testing procedure to avoid multiple comparisons. The carryover effect was analyzed using a model in which the interaction between treatment and time was added to the fixed effects of the main analysis model. The differences between the treatments at baseline and between each time point and baseline for each treatment were analyzed using a paired 