Discussion
diabetes mellitus, diabetic, lower blood glucose, type 2 diabetes, trauma
POSTOPERATIVE COMPLICATIONS, DIABETES MELLITUS, INSULIN RESISTANCE, TYPE 2 DIABETES, PATHOGENESIS, COMPLICATIONS
In our study, patients with type 2 diabetes in propofol group had lower blood glucose level, less-affected insulin resistance, and better inhibition of cortisol release compared to those in desflurane group. However, no significant difference regarding the incidence of complications between the two groups was found based on the current samples. The pathogenesis of diabetes mellitus is a complicated process, and other systems of the body such as circulatory system, respiratory system and nervous system may be affected at the later stage [Majority of earlier studies focused on the effects of propofol and volatile anesthetics on perioperative blood glucose in non-diabetic patients have concluded that the effect of propofol on intraoperative glucose metabolism was less than that of isoflurane and sevoflurane [As an influenced factor of surgical stress response, blood glucose indirectly reflects the intensity of stress response [Cortisol is one of the stress hormones that reflects the intensity of the body’s stress response. Cortisol secretion sensitively varies based on the severity and duration of the surgical trauma throughout the body [Previous studies suggested that patients with propofol maintenance anesthesia had a longer postoperative survival time than those with desflurane maintenance anesthesia [A limitation of our study that need to be mentioned is the sample size. The sample size in our study was calculated for blood glucose level comparison, which may not be large enough to show the difference of complications, especially long-term postoperative complications between the two groups. A larger sized trial may be needed to find the difference of postoperative complications between the two group in type 2 diabetic patients.