Pharmacodynamics
tumor
TUMOR
Thirty-two of the 39 patients provided archival (28/32) or fresh biopsy (4/32) tumor tissue specimens for AKR1C3 expression testing using the validated, automated IHC assay (NeoGenomics). Among the 32 specimens, 6 tumor tissue specimens did not have sufficient viable tumor cells and were non-evaluable. AKR1C3 H-scores by patient are listed in Fig. Antitumor activity in patients treated with OBI-3424 at postbaseline scans.