Ethics approval and consent to participate
The protocol was conducted in accordance with the Declaration of Helsinki and was approved by the ethical committee of the Faculty of Dentistry/Faculty of Pharmacy, Mahidol University (COA.No.MU-DT/PY-IRB 2021/022.1702). Moreover, this study was registered with Thai Clinical Trials Registry (TCTR20220521001). Informed consent was obtained from all participating parents.