Phase 1b
DLTs, leukopenia
LEUKOPENIA
Twenty-one patients were enrolled in the GC cohort in phase 1b; all patients received 560 mg ibrutinib with docetaxel; median duration of ibrutinib exposure was 2.7 months and median docetaxel exposure was 1.4 months. Fourteen patients were DLT-inevaluable due to dose interruptions. Seven patients were DLT-evaluable. Two of these seven had DLTs (29%); one patient experienced grade 4 leukopenia for 3 days after receiving ibrutinib 560 mg QD plus docetaxel 75 mg/m