Definition of concurrent mutations and pathogenic concurrent mutations
L858R
EGFR EXON 19 DELETION, MUTATION
Concurrent mutations were defined as gene mutations detected by NGS besides EGFR exon 19 deletion or exon 21 L858R mutation but excluding the concurrent rare EGFR mutations in line with previous studies. Pathogenic concurrent mutations were defined as gene mutations besides EGFR exon 19 deletion or exon 21 L858R mutation, which was predicted as deleterious or potentially deleterious with at least two software among PolyPhen2, PROVEAN, and Mutation Taster.