RESULTS
bleeding, nausea, erythema, pain, dizziness, dandruff
ADVERSE REACTIONS, BLEEDING, SCAR, GROUP B, ERYTHEMA, LENS, DANDRUFF
The clinical efficacy of the two groups was evaluated in the 4th week after the last PRP injection. According to the comparison of hair images, we detected that hair became thicker, and hair color deepened and increased hair coverage after PRP therapy. According to the photographs of three enrolled patients, it was found that the global appearance and hair quality were improved in visual assessment (Figure Global photographic assessment at baseline and 3 months. Patient 1 Group A (PRP+M): Baseline 3 months. Patient 2 Group B (PRP+P): Baseline 3 months. Patient 3 Group A (PRP+M): Baseline 3 months. Patient 4 Group B (PRP+P): Baseline 3 months.Clinical efficacy.(χOn trichoscopic evaluation, increased hair diameter diversity (HDD) and positive brown peripilar sign around hair follicles were observed in almost 100% of the patients. Some patients had presentations like white and yellow dots, accompanied by increased scalp greasy and dandruff. In the comparison of dermoscopic (20x lens) hair analysis statistics, compared with baseline, the average hair density/quantity of all patients increased after treatment, which were 54.64 ± 18.32 versus 64.94 ± 16.07 and 70.43 ± 23.62 versus 82.93 ± 20.01, respectively. The difference was statistically significant (Statistics of hair density, hair count, and mean hair diameter at baseline and 3 months.
Trichoscopic comparative evaluation. Hair count, hair density, and mean hair diameter were assessed at baseline and 3 months. (Dermoscopy [polarized 20x])Comparison of average dermoscopic hair density and hair diameter before and after treatment.In terms of patient self‐satisfaction evaluation, five patients in group A were very satisfied, eight were satisfied and two were dissatisfied. The overall satisfaction was 86% (13/15). In group B, two patients were very satisfied, nine were satisfied and four were dissatisfied. The overall satisfaction was 73% (11/15). The overall satisfaction of group A was higher than group B, indicating that PRP combined with the topical 5% minoxidil group has higher satisfaction. The adverse reactions of PRP injection therapy were transient pain at the injection site and a burning sensation, which could be relieved after ice application and tolerated. Spot bleeding and erythema may subside spontaneously without a scar after injection. In the course of treatment, no serious adverse reactions occurred, except for one patient who experienced mild dizziness and nausea during injection, which was self‐alleviated after a few minutes. The primary outcome of our study was the effectiveness of the treatment demonstrated by physicians assessing the improvement in hair growth under trichography and photography. Secondary outcomes, as discussed above, were measured by patient self‐satisfaction and the occurrence of adverse reactions. The outcomes demonstrated the safety and effectiveness of the automated method prepared PRP injection combined with topical 5% minoxidil therapy.