Randomization and masking
Enrolled patients were randomized to receive either CT followed by LET or LET alone at an approximate ratio of 1:1 by dynamic allocation with stratification by the following factors: response to neoadjuvant LET therapy (CR or PR vs. SD), progesterone receptor (PgR) status at primary enrollment (positive vs. negative), pathological node status (positive vs. negative), age at primary enrollment (< 60 vs. ≥ 60 years), and study center.