Ethics approval and consent to participate
Ethics approval was collected for each trial site (Partners Human Research Committee, Protocol # 2017P000196/PHS, Brigham & Women’s Hospital, Boston, MA and Western Institutional Review Board, Protocol # COVMO0560-PRODIGY, The Ohio State University Wexner Medical Center, Columbus, OH). Written informed consent was required before a patient was enrolled in the trial. All methods were carried out in accordance with relevant guidelines and regulations (Declaration of Helsinki).