Data analysis
The efficacy was analyzed in the intention-to-treat population, defined as participants who completed baseline assessments. For missing data, the multiple imputation method was used under the missing-at-random (MAR) assumption. The sensitivity of MAR assumption of missing data was tested with a pattern-mixture model [Categorical variables, including categorical baseline variables, cessation rate of sleeping medications and incidence of AEs, were analyzed using Chi-square or Fisher’s exact tests. Unpaired 