Statistical analyses
PD
Subjects who received placebo were pooled into 2 treatment groups: placebo with low-salt diet and placebo with normal-salt diet. Descriptive statistics were calculated for PK, PD, and safety measures. The effects of dose on plasma aldosterone and cortisol (free and total) and their precursors were investigated using an analysis of variance model on change in AUC over 12 h from day −1 to day 1 and from day −1 to day 10. Data are presented as change from baseline in least squares mean (90% CI) AUCThree subjects had negligible aldosterone concentrations on day −1 that increased to more expected levels on days 1 and 10. Including these subjects in the baseline analyses skewed the results and disrupted cross-treatment comparisons; therefore, they were considered outliers and were not included in the data presented here.