Discussion
infectious, Lactobacillus rhamnosus, neuropathic pain, Lactobacillus acidophilus, Lactobacillus casei oral supplementation, fibrosis, pain, burns, Lactobacillus casei
FIBROSIS
This is the first study, which evaluated the effect of Lactobacillus casei on episiotomy wound healing. The results of the present study indicated that the use of Lactobacillus casei oral supplementation was effective in episiotomy wound healing. Consistent with the findings of the present study, Abootaleb et al. [The findings of a study indicated no difference in the treatment and healing process of grade 2 infectious and grade 3 non-infectious burns using Lactobacillus plantarum or silver sulfadiazine ointment. Additionally, the use of Lactobacillus plantarum was suggested as an alternative treatment for burns, since it had a similar effect to classical treatment of burn wounds. However, due to the small sample size and low statistical power of the study, it was recommonded to conduct further studies with a large sample size [In line with the findings of the present study, Sinha et al. [In a study in Brazil, the use of combined oral probiotics (L. paracasei, Bifidobacterium lactis HN0019, L. rhamnosus HN001, and L. acidophilus) after surgery at a dose of 250 mg a day for 15 days resulted in faster wound healing in rats compared with placebo group, as reducing the inflammatory phase, accelerating the fibrosis process, and collagen deposition were mentioned as the mechanism of its possible effect [Twetman et al. [In the present study, the perceived pain in the intervention group was less than that in the control group on 5 ± 1 and 15 ± 1 days after birth. However, this decrease was not statistically significant. Consistent with the findings of the present study, in the study of Twetman et al. [Inconsistent with the findings of the present study, Lei et al. [In addition, the results of a laboratory study indicated that taking 1 cc of combined supplementation of probiotics (Lactobacillus plantarum, Lactobacillus delbrueckii, Lactobacillus acidophilus, Lactobacillus rhamnosus, and Bifidobacterium bifidum) daily for up to 21 days had a relief effect on induced neuropathic pain of the sciatic nerve of rats, as its possible mechanism has been attributed to the antioxidant properties of probiotics [