Discussion
endocrine disease
EXTERNAL GENITALIA, PRECOCIOUS PUBERTY, PRECOCIOUS PUBERTY, PATHOGENESIS, ENDOCRINE DISEASE
Precocious puberty is a common endocrine disease that is usually considered to be caused by the premature initiation of the hypothalamic-pituitary-ovarian axis (HPGA), resulting in the premature development of internal and external genitalia (The pathogenesis of precocious puberty is related to early initiation of the HPGA, and the pivotal factor in the HPGA initiation is the pulsatile secretion of gonadotropin-releasing hormone (GnRH) (Additionally, the estrogen receptor (ER) has been demonstrated to be strongly correlated with the pubertal development in children (Despite the findings of this study, the current study has certain limitations which should not be overlooked. Firstly, despite the advancements being made, there is still a lack of metabolomics data available for the precise identification of metabolites. Secondly, the sample size was too small. To improve this, it is essential to conduct future studies with a greater sample size of patients. Thirdly, due to the restrictions imposed by certain databases, it is not possible to retrieve all the active targets of EGCG, and the targets and pathways are interrelated and modulate each other. Further research is still required to gain a more comprehensive understanding of EGCG’s pharmacological effects and mechanisms in the prevention of obesity-related precocious puberty, which can be explored and confirmed through both In summary, EGCG may serve a role in preventing obesity-related precocious puberty through targets such as AKT1, EGFR, ESR1, STAT3, IGF1, and MAPK1 that acted on multiple signaling pathways, including the estrogen, PI3K-Akt, MAPK, and Jak-STAT pathways. In this study, we investigated the mechanism by which EGCG prevented obesity-related precocious puberty through a network pharmacology approach and found that multiple targets and pathways were involved in the underlying mechanism. This study provided a theoretical foundation for subsequent research.