Outcome Data
depression, anxiety
There were 1224 participants (28.7%) with missing HADS scores for week 24. We replaced missing HADS score with the last score recorded after 20 weeks, leaving 1029 participants (24.2%) who had missing outcome data on HADS and were excluded from the complete case analysis. The mean (SD) baseline HADS score was 4.25 (3.68) (median [IQR], 3 [1-6]) for anxiety and 2.44 (2.91) (median [IQR], 1 [0-4]) for depression.