ACTH, serum and urine GC metabolites
At baseline, circulating cortisol and ACTH levels did not differ between the two groups (Table After 7 days of treatment, circulating prednisolone levels were similar in the AZD4017 and placebo-treated groups (650 ± 282 vs. 723 ± 430 nmol/L, p = 0.63, AZD4017 vs. placebo). Similarly, there were no differences in circulating prednisone levels (142 ± 62 vs. 103 ± 52 nmol/L, Prior to treatment, the urinary (5aTHF+THF)/THE ratio (indicative of 11β-HSD1 activity) was similar in both groups (0.85 ± 0.19 vs. 1.04 ± 0.37, 