Study setting
This prospective single-center and randomized clinical trial was approved by the ethical committee of The First Affiliated Hospital of Wenzhou Medical University on 21/09/2021 (Chairperson Pro. Jinglin Xia, NO.KY2021-119) and registered at chictr.org.cn (ChiCTR2100053635) on 26/11/2021. The study was conducted in the First Affiliated Hospital of Wenzhou Medical University between 01/12/2021 and 30/06/2022 according to the criteria of Declaration of Helsinki, and informed consent was obtained from each participant.