Study design
This is a double-blind randomized clinical trial study using the split mouth model conducted according to the Consolidated Standards of Reporting Trials (CONSORT). The study was approved by the Institutional Review Board of the University of Pernambuco under protocol no. 5.626.742 / CAAE 58646222.1.0000.5207 and registered in the Brazilian Registry of Clinical Trials–ReBEC (UTN: RBR-5fxbqsf). This study follows CONSORT statement (