Funding
This work was supported by the National Nature Science Foundation of China (82073396 and 81872201 for H Zhao, 81872449 for L Zhang, 82002409 for Y Ma), Guangdong Basic and Applied Basic Research Foundation (2018A0303130243 for H Zhao, 2020A1515010020 for Y Ma). These two clinical trials were sponsored by Qilu Pharmaceutical Co., Ltd.