Source data
SKIN

Tables for number of patients screened, enrolled, treated and discontinued; Mean IRAK4 versus Time Data in PBMCs after single dosing; Individual IRAK4 Data in PBMCs at 48 h after single dosing; Mean IRAK4 Data in PBMCs at 48 h after single dosing; Mean IRAK4 versus. Time Data in PBMCs after multiple dosing; Individual IRAK4 Data in PBMCs at day 14 after multiple dosing; Mean IRAK4 Data in PBMCs at day 14 after multiple dosing; Mean IRAK4 versus Time Data in skin after multiple dosing; Individual IRAK4 Data in skin at day 14 after multiple dosing; Mean IRAK4 Data in skin at day 14 after multiple dosing.IRAK4 Reduction in PBMCs versus Plasma Conc data for Part C and Part B; Individual IRAK4 Data in skin in AD/HS patients and HVs; Mean IRAK4 Data in skin in AD/HS patients and HVs.Raw data are already provided in the NCBI Sequence Read Archive. Added processed data underlying the figures.Mean change and s.e.m. for each panel.Discovery proteomics data of human PBMCs treated with KT-474 versus DMSO. logMean ΔQTcF Data in MAD3 and AD/HS patients on days 7, 14, 21 and 28; Individual ΔQTcF Data in MAD3 and AD/HS patients on days 7, 14, 21 and 28.Mean Plasma Concentration versus Time Data after single dosing in HVs; Mean Plasma Concentration versus Time Data after multiple dosing in HVs; Mean Skin Concentration versus Time Data after multiple dosing in HVs; Mean Plasma Concentration versus Time Data after multiple dosing in AD/HS patients; Mean Skin Concentration versus Time Data after multiple dosing in AD/HS patients.Mean reduction in LPS-stimulated cytokines after single dosing; Individual reduction in LPS-stimulated cytokines after single dosing; Mean reduction in R848-stimulated cytokines after single dosing; Individual reduction in R848-stimulated cytokines after single dosing.Mean change and 80% confidence interval; change over time.Individual data points for counts in table.Individual data points for counts in table.Individual data points for counts in table.Individual analyte readings, mean, standard deviations and 