Conclusion
ischemia, hypoperfusion, acute ischemic stroke
ISCHEMIA, HYPOPERFUSION
HD C-tDCS is a noninvasive targeted acute ischemic stroke treatment strategy that can be efficiently applied in emergency settings. Our results suggest beneficial effects upon penumbral salvage, hypoperfusion region, and qrCBV. The enhancement of qrCBV poststimulation followed a dose-response pattern suggesting collateral enhancement as a mechanism through which HD C-tDCS may alleviate ischemia and possibly promote vessel recanalization. Our data warrants conduct of larger safety and efficacy trials of HD C-tDCS as an AIS therapy and acute stroke-specific refinements in HD equipment design to further accelerate deployment time.