Impact statements

Propofol is commonly used for procedural sedation, but since it has the disadvantage of a narrow therapeutic index, alternative sedation drugs with improved drug dosing properties are desirable.Ciprofol is a novel drug for procedural sedation and general anesthesia with a potency about 4–5 times higher than propofol, which reduces the necessary amount of active drug required to induce sedation compared to propofol.In this phase 2a clinical trial, 0.5 mg/kg ciprofol had similar outcomes to 2.0 mg propofol but a future randomized study is warranted.