Treatment results
tumor, pneumonia, diaphragmatic muscle, anastomotic leakage, abdominal hemorrhage
TUMOR, PNEUMONIA, INTESTINAL OBSTRUCTION, POSTOPERATIVE COMPLICATIONS, INTRAPERITONEAL ABSCESS, COMPLICATION
For both groups, open and laparoscopic D2 radical resections were performed on 108 and 26 patients, respectively. All enrolled patients achieved R0 resection. Multivisceral resection due to tumor invasion was performed in 4 patients, including 3 patients in the HIPEC group (one patient each had splenectomy, pancreatectomy, and splenectomy combined with left lobe partial hepatectomy) and in 1 patient in the non-HIPEC group (diaphragmatic muscle resection). No operation-related mortality or intraoperative morbidity occurred in either group.However, postoperative complications regarded as Clavien‒Dindo grade II or above were observed in 11 patients, including 6 patients in the HIPEC group and 5 patients in the non-HIPEC group, without a significant difference. The most common complication was pneumonia (5 cases), followed by intestinal obstruction (2 cases), anastomotic leakage (2 cases), intraperitoneal abscess (1 case) and abdominal hemorrhage (1 case). Resurgery was required in the patient with abdominal hemorrhage for debridement and hemostasis. The other patients suffering from postoperative complications were treated with conservative strategies, and the conditions were well controlled.In the HIPEC group, 42 (62.7%) patients completed two HIPEC treatments as planned, and the other 25 (37.3%) patients received only one treatment. In both groups, postoperative chemotherapy with the SOX regimen was performed on all patients. A total of 44.8% of patients in the HIPEC group completed at least 6 cycles of postoperative chemotherapy with an average of 4.5 cycles (range 2–8 cycles), while 46.3% of patients in the non-HIPEC group completed at least 6 cycles of postoperative chemotherapy with an average of 4.5 cycles (range 2–8 cycles).