SAD
SAD
Plasma concentration–time profiles overlaid for each dose group in the SAD (linear) are in Figure Overlaid mean plasma KCL‐286 concentration Summary of pharmacokinetic parameters at Day 1 (PK set)—single ascending dose.Abbreviations: Ae, KCL‐286 excreted unchanged in a collection period; AeData show mean and standard deviation in brackets.In concentration–time data, there was a short lag time between dosing to appearance of KCL‐286 in plasma which became quantifiable at 0.25 h. Absorption was gradual. For the highest dose, 100 mg, the mean C