Author Contributions
M.K. designed and conducted this study, performed the statistical analysis, and wrote the first draft of the manuscript. H.Z. and T.K. contributed to the design of study and performed experiments. Y.M. performed experiments. T.O., K.T., T.I. and T.S. contributed to the conception and design of the study. S.O. contributed to the funding acquisition, the conception and design, conducted this study including executing the blood data analyses, and reviewed the manuscript. All authors have read and agreed to the published version of the manuscript.