Author contributions
MH
DB, JD, MH and AEL: initiation of the study design and implementation. DB, KW, AR, MFJ: BAT and therapeutic intervention. MS, SS, PP, MH, JD, AEL: supervision. DB, KW, MH, AEL and JD: analysis of data. DB, KW, MH and AEL: writing of the manuscript. All authors contributed to refinement of the study protocol and approved the final manuscript.