Author contributions
P.Y. and Z.Z. conceived and designed the study. P.Y. was the chief investigator and oversaw the trial throughout. P.Y., L.D., Q.W., Y.G., Y.P., G.S., X.L., F.Z., C.T., Y.W., and C.Z. recruited patients and collected the data. Z.Z. and L.D. conducted the data analysis. Z.Z. wrote the first draft of the manuscript and P.Y. contributed to the critical revision of the manuscript for important intellectual content. All authors have given the final approval of the manuscript for submission and publication.