4. Sample Size Calculation
Knowledge was taken as the primary outcome variable for the computation of sample size. A mean difference of 0.5 SD (moderate effect size) is considered clinically important to consider that the intervention is effective. Assuming a power of 80% and a significance level of 5%, the sample size for the comparison of two group means is 64 per group. Adjusting for a 20% dropout rate, the required sample size per group is 80 per group (