Neurophysiological assessment
This includes:the Motor Evoked Potentials (MEPs) to evaluate the changes in corticospinal tract integrity. MEPs will be recorded from the bilateral Abductor Digiti Minimi (ADM, for the upper limbs) and Abductor Hallucis (AH, for the lower limbs) muscles by following the methodology reported in [the Somatosensory Evoked Potentials (SSEPs) to evaluate the ascending sensory pathways. SSEPs will be recorded according to clinical standards, as briefly reported below. Electrical stimulation will be delivered to the median (upper limbs) and tibial (lower limbs) nerves (at motor threshold or 4 times sensory threshold, when applicable). Responses will be recorded at the Erb point (N9), cervical cord (N13) and scalp (N20) for the upper limbs and at lumbar cord (N22) and scalp (P40) for the lower limbs via bipolar derivations by means of surface electrodes, bandpass filtered between 30–3000 Hz and averaged (at least 2 averaged responses of minimum 100 stimuli each, according to patients’ collaboration and recording conditions – signal to noise ratio) [the high-density EEG recordings to evaluate the neurophysiological substrates of the experimental intervention efficacy at Each recording session will consist of (i) four minutes of EEG recording at rest (closed and opened eyes), (ii) four runs during the MI tasks (MI session), (iii) four runs during the finger tapping task (FT session) whether the participant can perform the task.Each MI session will consist of 4 runs, 40 trials each. Each run will consist of 2 tasks: i) hand kinesthetic MI [Changes of the motor relevant oscillatory activity will be measured as significant changes in the Power Spectral Density (PSD) maps (details in [As for the FT, the session will consist of 4 runs, 30 trials each. In each trial the participant will attempt the execution of the index finger tapping movement with his dominant hand assessed as in [