Overall LRF
locoregional failure
DISEASE, STD, METASTASES, RESIDUAL TUMOR
An LRF was detected in 54/460 (11.7%) and 36/446 (8.1%) patients in the EXP and STD groups, respectively (Plot development of locoregional failure against time in years after randomization. Red: no resection surgery for other reasons than entering a W&W strategy (5 vs. 5). Light blue: R2 (residual tumor locally (all these patients also had distant metastases) (5 vs. 5). Green: locoregionally progressive disease after having refused surgery (0 vs. 2, referred to the LRR group) Dark blue: LRR after an R0 resection (28 vs. 15). Pink: LRR after an R1 resection (16 vs. 9).