Sample size calculation
Sample size was calculated using the Cochran-Armitage Test for the trend in proportions using PASS®, (Version 11.0.7, NCSS, LLC, Kaysville, UT, USA), in accordance with the primary outcome of this study. According to a pilot study for the 4 groups with infusion doses of 2.5, 5.0, 7.5, and 10 IU/h, the proportions of adequacy UT were 45, 61, 74, and 90%, respectively. The full sample of 76 subjects achieved 90% power to detect a linear trend using a two-sided Z-test and a significance level of 0.05000. To account for any potential dropouts (estimated as 20% of the total patients), the sample size was increased to 25 patients in each group.