Acknowledgements
D.H., Cancer
WRIGHT, CANCER
This trial was funded by Day One Biopharmaceuticals. We thank the patients, families, caregivers and clinical investigators for their participation in the FIREFLY-1 trial. We are deeply grateful for the site coordinators and trial staff who are instrumental in making this work possible. The authors would like to thank the Pacific Pediatric Neuro-Oncology Consortium (PNOC) for their partnership in the conduct of this trial. We also would like to acknowledge and thank the PNOC014 investigators and trial team (principal investigator: K. Wright) for generating the initial observation of the activity of tovorafenib in pLGG in their phase 1 trial. We also thank M. C. Cox for his contribution to protocol development and trial management. Medical writing support was provided by M. Hoke and S. Govinda Raju of Day One Biopharmaceuticals and J. Heighway and A. Cleasby of Cancer Communications and Consultancy Ltd., funded by Day One Biopharmaceuticals. D.S.Z. is supported by grants from the National Health and Medical Research Council (Synergy Grant 2019056 and Leadership Grant APP2017898) and Cancer Institute New South Wales Program Grant TPG2037. D.H. is supported by funding from the National Institute for Health and Care Research (NIHR) Great Ormond Street Hospital Biomedical Research Centre. The views expressed are those of the author(s) and not necessarily those of the National Health Service, the NIHR or the Department of Health and Social Care.