Ethics approval
This randomized controlled trial was approved by the Institutional Review Board of Seoul National University Hospital (#1707-109-871, on September 11, 2017) and registered at clinicaltrials.gov (NCT03291210, on September 25, 2017) before patient enrollment. The study was conducted according to the Good Clinical Practice guidelines and Declaration of Helsinki. Written informed consent was obtained from all participants, who could withdraw at any time.