Treatment
VIRUS, CHRONIC VIRAL INFECTIONS
Pleconaril and ribavirin were administered as oral solutions (to enable weight-based dosing) at home as separate mixtures for 26 weeks. Combination treatment was chosen to increase and broaden the antiviral effect and to reduce the risk of emergence of drug-resistant virus variants. A 6-month treatment was chosen based on clinical experience from treating other chronic viral infections. In cell models, pleconaril eradicated persistent enterovirus infection in 5–6 weeks