Secondary endpoints analyses
headache
DISEASE
Figure 
Time by group analysis for change in headache frequency and percentage change from baseline to month 12. Patients in the TaU + MIND group outperformed those in the TaU group at MSQ and MIDAS scores at the 12-month follow-up only, whereas the two groups overlapped throughout the study at WHODAS-12 and HIT-6 scores (see Supplementary Figs. 1–4 for MSQ, MIDAS, WHODAS-12 and HIT-6 time by group interactions in Additional file Patients in the TaU + MIND group showed significantly lower total disease, indirect and direct healthcare cost than those in the TaU group (
Time by group analysis for day-equivalent loss of productive time (LPT) from baseline to month 12No time by group effect was found for drug intake. However, patients allocated to TaU + MIND outperformed those in the TaU group for the reduction in total drug intake (
Time by group analysis for all-drugs intake from baseline to month 12. 