Discussion
non-tumourous liver, tumour, HCC
PATHOLOGY, TUMOUR
HCC requires a multidisciplinary approach involving specialists in hepatology, oncology, interventional radiology, nuclear medicine, pathology and surgery. The RALLY study aims to assess the safety of unilobar To date, numerous studies investigated the outcomes of unilobar radioembolization [Current activity planning methods are either based on the body surface area (BSA) model or the Medical Internal Radiation Dose (MIRD) mono-compartment model (Fig. Activity planning models. While the BSA and mono-compartment models assume homogenous distribution within the perfused part of the liver (indicated in the picture with equal distribution of blue microspheres in tumour and non-tumourous liver tissue) the multi-compartment model postulates three compartments with different activity uptakes: tumour, non-tumourous liver tissue and lung tissue (not depicted). The multi-compartment model permits the selection of a prescribed dose that optimizes the dose to one of the compartments – in the case of the RALLY study this is the non-tumorous liver tissue. The expected activities in each compartment will be based on the distribution of the Using In conclusion, this is the first prospective clinical study to assess the unilobar radioembolization-surgery treatment as a whole. The results will likely impact the clinical management of potentially curative HCC patients.