Patients and design
anaemia, varus-valgus, cardiovascular disease, end-stage osteoarthritis, lower limb arterial occlusion, flexion deformity, venous thrombosis
ANAEMIA, OSTEOARTHRITIS OF THE KNEE, CARDIOVASCULAR DISEASE, DISEASE, LIVER DISEASE, HAEMATOLOGICAL DISORDERS, VENOUS THROMBOSIS
This prospective, double-blind randomised study was approved by The Institutional Review Board of Panzhihua Central Hospital (no. pzhszxyyll-2022-10) and registered in the Chinese Clinical Trial Registry (ChiCRT-2100053885). Informed consent was obtained before participation in the study. Ninety patients with osteoarthritis of the knee who underwent primary TKA from 01/2022 to 07/2022 in our hospital were selected. All patients 18 years of age or older who were scheduled for primary unilateral TKA for end-stage osteoarthritis were eligible for inclusion. Exclusion criteria: (1) preoperative anaemia or other haematological disorders; (2) preoperative history of severe cardiovascular disease and/or still taking oral anticoagulants; (3) preoperative unilateral lower limb arterial occlusion, venous thrombosis or history of disease; (4) preoperative preexisting autologous blood transfusion or request for blood return device; (5) contraindication for the use of TXA or low molecular weight heparin; (6) perioperative use of erythropoietin, iron, antiplatelet therapy or blood transfusion; (7) preoperative diagnosis of liver disease; (8) BMI > 35; (9) flexion deformity of ≥ 30°, varus-valgus deformity of ≥ 30° (10) inability to cooperate with the trial.