Author contributions
RS
QL designed the clinical trial. HJ, GY, YZ, SY, XD, NX, and QL recruited and treated patients, analyzed data, and wrote the manuscript. HJ, YC, SY, and RS did the statistical analysis. DL, JX, ZS, LD, XL, HZ, and ZG led the trial within each institute. MD, PS, FH, ZF, LX, RL, XJ treated and took care of patients on the trial. GY, and ZY performed laboratory studies associated with the trial. All authors interpreted the data, drafted and reviewed the manuscript, and approved the final version of the manuscript.