Introduction
RILD, REILD, liver malignancies, liver disease, primary liver tumors, sinusoidal obstruction syndrome
SINUSOIDAL OBSTRUCTION SYNDROME, LIVER METASTASES, HEPATOCELLULAR CARCINOMA AND CHOLANGIOCARCINOMA, LIVER DISEASE
Various forms of radiotherapy are available for the treatment of liver malignancies today. Stereotactic body-radiotherapy (SBRT), Y90-radioembolisation (Y90-RE) and interstitial brachytherapy (iBT) are known to be effective in liver oligometastases as well as primary liver tumors (hepatocellular carcinoma and cholangiocarcinoma) (Baere et al. Radiation or radioembolization induced liver disease (RILD or REILD) is a limiting factor of these treatment modalities and originates from the sinusoidal obstruction syndrome, a condition also known to occur after certain chemotherapies or bone marrow transplantation (Lawrence et al. In a prior randomized trial, the effect of pentoxifylline (PTX), ursodeoxycholic acid (UDCA) and low molecular weight heparin (LMWH) as a potential treatment of RILD/REILD by the occurrence and extent of fRILI after interstitial brachytherapy (iBT) of liver metastases was analyzed (Seidensticker et al. In the recent trial, we altered the study protocol by removing LMWH and prolonging the administration of PTX and UDCA to 3 months to gain further information on the development of fRILI.