Trial structure
DISEASE
The initial SNAP trial silo, domain, and subdomain structure at commencement is summarised in Table The primary endpoint is all-cause mortality at 90 days after platform entry.Each subdomain initially consists of two interventions only.The subdomains of each silo within the backbone antibiotic domain are unique.For the adjunctive and early oral switch domains, subdomains are the same across silos.Only participants who have clinically stable disease and the ability to absorb or adhere to oral regimens, at day 7 for uncomplicated disease or day 14 for complicated disease will be eligible for the early oral switch domain.Participant flow, randomisation, and reveal sequencing. SAB, 