Recruitment
depression, tumor, insomnia, breast cancer
TUMOR, METASTASES, RECRUITMENT, BREAST CANCER
Six medical oncology centers have been identified in Franche-Comté (France) for the recruitment. Women are recruited and deemed eligible if they meet the following criteria: (1) Aged over 18 and ≤ 65 years; (2) early breast cancer confirmed histologically; (3) undergoing first adjuvant or neoadjuvant sequential chemotherapy with anthracyclines and taxanes; (4) diagnosed as having insomnia; (5) no contraindication to performing physical activity (PA); (6) and either using appropriate contraception or menopaused.Patients are not eligible in case of: (1) metastases; (2) treatment with melatonin or hypnotics; (3) no diagnosis of insomnia; (4) documented depression; (5) resting oxygen saturation (SaOPotentially eligible patients are identified during a multidisciplinary tumor board (MTB) composed of oncologists, surgeons and radiotherapists. The choice of the type of surgery, chemotherapy and radiotherapy regimens is left at the discretion of the treating physician.Potential candidates receive the study information when they come to the hospital for clinical follow-up. If they are interested in participating in the study, a researcher contact them to conduct a phone screen (see below).Prior to participation, all participants must provide written informed consent.The participants are instructed to maintain their regular exercise activities, but not to participate in any new exercise program during the study period other than the program proposed in the context of the study.