Background
®, CLI, PAD, amputation, Buerger’s disease, atherosclerosis
PAD, PERIPHERAL ARTERIAL DISEASE, ATHEROSCLEROSIS
Peripheral arterial disease (PAD) is characterized by narrowing and blockade of upper and/or lower extremities, usually based on underlying obliterating atherosclerosis which reduces arterial flow [The last available option for PAD patients who have exhausted their pharmacological or non-pharmacological approach and surgical option is amputation [As per clinical studies, stem cell-based therapy is feasible and may have beneficial effects when it is delivered to the ischemic muscle which has demonstrated therapeutic angiogenesis for treating ischemic tissue and preventing major amputation in CLI patients unsuitable for revascularization [Our previous phase II and phase IV study showed that the use of stempeucel® was safe and efficacious at a dose of 2 million cells/kg body weight in patients with CLI due to Buerger’s disease (BD) [