3.5.1. Intention-to-Treat Analysis
There was a significant reduction in hs-CRP in the TRE group, when compared to the usual care group with a mean difference of −1.68 (−3.20, −0.14), while there was no significant difference in hs-CRP levels between TRE plus BE and usual care groups with a mean difference = −0.43 (−1.91, 1.05). In addition, Hs-CRP levels did not differ significantly between TRE plus BE and TRE alone groups (