Limitations and future research
Although randomization was done using a computer-generated list, the IG was significantly younger than the CG. To mitigate this, analyses were adjusted by age, but indirect age-associated differences (e.g. plasticity) may still have contributed to differences between groups. Additionally, the intervention period in this study was short compared to other training programs in HD patients. A longer intervention period may optimize motor learning and provide more benefits. The relationship between other factors, such as diet, risk of falling, daily physical activity, as well as clinician and participant attitudes towards iExergame training should be examined in future studies.