Study Design and Participants
cough, ’ chronic cough, RCC
RCC
Participants were 18 years of age or older with ROCC, defined as a chronic cough (i.e., cough lasting > 8 weeks) with an onset < 12 months prior to the screening visit (i.e., < 14 months after the onset of cough symptoms). Participants’ chronic cough was diagnosed as either RCC or UCC according to the American College of Chest Physicians (ACCP) guidelines [Major exclusion criteria included active or recent smoking (within 12 months), angiotensin-converting enzyme inhibitor treatment (within 3 months), and FEV1/FVC ratio < 60% within a year prior to study entry. Study procedures are detailed in Fig. Study design