General rules
diarrhoea
No change in TAC dosing should be performed if the TAC trough level does not reflect a steady state, e.g. due to the following: low TAC level due to a missed dose or earlier intake than usual the day before the blood draw. High TAC level due to an intake at the morning before the blood was drawn or later than usual at the day before the blood draw. Suspected drug or dietary interaction with TAC. Suspected high TAC levels due to diarrhoea. In these cases, the TAC trough level has to be repeated within a week. If TAC level is back to a steady state, TAC dosing has to performed according to the allocated treatment group. Corticosteroids and antimetabolites will not be dosed according to the TTV level. Centres are encouraged to keep the antimetabolite dose stable.