Bone microindentation measurements
painless, oedema
OEDEMA, SKIN INFECTION
Bone microindentation was measured using an Osteoprobe instrument (Active Life Scientific, Santa Barbara, CA, USA) according to a protocol previously described (To minimize interobserver variation, all measurements for this study were taken by the same investigator (RGF) that was blinded for arm of treatment. As previously described, the microindentation procedure is minimally invasive, safe, painless, and takes less than 5 minutes and the software provides results immediately. Contraindications for this technique included local skin infection, significant local oedema, and/or thick subcutaneous adipose tissue at the site of indentation.