Patient characteristics
MODS, Comorbidity
MULTIPLE ORGAN DYSFUNCTION SYNDROME, MODS, CRITICALLY ILL
A total of 817 patients from 5 centres were initially assessed for study eligibility from July 2022 to December 2022. Among them, 699 were excluded due to not meeting the inclusion and exclusion criteria, while six declined to participate. Consequently, 112 patients were randomly allocated. Of these, eight patients withdrew during the intervention, nine patients passed away after 60 days of enrollment, and two patients were lost to follow-up at one-month discharge. Therefore, a total of 101 patients (28 in the RT group, 24 in the HMB group, 24 in the combination group, and 25 in the control group) underwent follow-up testing. Thus, the intention-to-treat (ITT) analysis included a total of 112 patients, as shown in Fig. Five centres were included in this study, with patient numbers of 46 (41.1%), 25 (22.3%), 23 (20.5%), two (1.8%), and 16 (14.3%), respectively, and there were no statistically significant differences between the four arms (P > 0.05). The average age of all patients was 59.87 years, while the average ages of the four categories were 55.44, 62.68, 60.04, and 61.18 years, respectively, with no statistically significant differences (Patient characteristicsBMI: Body Mass Index = Weight / Height^2 (kg/m^2); MODS: Multiple Organ Dysfunction Syndrome; APACHE II: Acute Physiology and Chronic Health Evaluation II; SOFA: Sequential Organ Failure Assessment; NRS2002: Nutritional Risk Screening 2002; NUTRIC: Nutrition Risk in Critically Ill; CCI: Charlson Comorbidity Index