Study objectives
toxicity, tumor, malignant disease
SECONDARY, TUMOR, MALIGNANT DISEASE
The primary objective of the study is to evaluate the anti-tumor activity and toxicity of commercially available, EMA-approved targeted anti-cancer drugs used off-label to treat patients with advanced malignant disease harboring a known or predicted targetable genomic alteration.The secondary objectives are 1) To perform refined biomarker analyses (e.g., WGS) on serial fresh tumor samples and liquid biopsies, and 2) to study mechanisms of resistance using serial fresh tumor and liquid biopsies.