Subjects
orthostatic, tachycardia, heart block, psychiatric, ventricular arrythmias, arrhythmias
SUDDEN DEATH, HEART BLOCK, LONG QT SYNDROME, SINUS NODE DYSFUNCTION, ORTHOSTATIC HYPOTENSION, ARRHYTHMIAS
Subjects were included in the study if they were between the ages of 18 and 55 years and in good health based on medical and psychiatric history, physical examination, electrocardiogram (ECG), orthostatic vital signs, and routine laboratory tests (blood chemistry, hematology, coagulation, and urinalysis). Subjects had to be nonsmokers and have a body mass index (BMI) ≥ 18 and ≤30 kg/mSubjects were excluded if they had (1) a personal or family history of long QT syndrome, complex ventricular arrythmias, or family history of sudden death; (2) personal history of or current clinically significant arrhythmias; (3) prolonged QTcF (>450 ms); (4) seated BP > 150/90 mm Hg or <90/50 mm Hg; (5) resting heart rate >100 beats per minute (bpm) or <50 bpm, sinus node dysfunction, or clinically significant heart block; (6) postural tachycardia or orthostatic hypotension; or (7) serum potassium greater than the upper limit of normal of the reference range and serum sodium less than the lower limit of normal of the reference range.