Conclusions
dry eye symptoms, hyperosmolarity
DRY EYE, EYE
Within DREAM, TO was weakly correlated with DED signs, explaining <5% variability in signs. Changes in tear osmolarity were not associated with changes in signs and symptoms of DED, indicating that the association may not be causal.Since 1970, when Mishima and colleagues found increased tear osmolarity (hyperosmolarity) in patients with dry eye compared to normal subjects, this relationship has been well documented.Although Bron and WillshireThe multi-center Dry Eye Assessment and Management (DREAM) study of 535 DED subjects evaluated the effects of high levels of omega-3 fatty acid supplementation on signs and symptoms in patients with moderate to severe DED with the hypothesis that dietary supplementation would improve dry eye symptoms and signs.