Efficacy and safety monitoring
TB, liver and renal function
Both groups had clinical visits before and monthly after the initiation of anti-TB treatment. Sputum smear microscopy, bacterial culture, routine blood tests, liver and renal function tests were performed at each visit, while a CT scan was obtained every two months. After treatment completion, additional follow-up was performed at 3, 6 and 12 months to evaluate the status of TB using bacterial culture and/or a CT scan. A structured case report form was used to collect demographic, clinical and laboratory information by trained research physicians. The details of microbiological work are presented in the online data supplement.