2.2. Participants
toxicity, Cancer
CANCER
This clinical trial was patterned according to the National Cancer Institute’s (NCI’s) recommendation for dose escalation to determine the toxicity of a drug [Screening involved measurement of the body weight, height, vital signs (blood pressure and pulse rate), complete blood count and blood chemistry-15 panel (glucose, creatinine, potassium, uric acid, albumin, calcium, magnesium, creatine phosphokinase, alanine aminotransferase, alkaline phosphatase, iron, cholesterol (total, high-density lipoprotein, and low-density lipoprotein), and triglycerides). This study was conducted according to the guidelines laid down in the Declaration of Helsinki and all procedures involving human subjects were approved by our Institutional Review Board. All participants provided written informed consent. The trial was registered with ClinicalTrials.gov Identifier: NCT04499482. The participant characteristics at screening are presented in 