Biomarkers of immunoediting (2).
Microphotographs of HLA class I and CD8 immunohistochemistry for representative patients in each ICR/GIE class (left). The plots represent the ICR and GIE sample scores, percentages of HLA-positive cells, and density of CD8 T cells. The presented data was derived from one experimental run independently reviewed by three different trained scientists. Source data are provided as a Source Data file.We then asked whether the patient groups defined by the ICR/GIE classification also experienced different long-term clinical outcomes. By stratifying patients according to the ICR/GIE classification of week 12 biopsies we found a slightly significant difference (Comprehensive assessment of the ICR, GIE, CD8Collectively, these findings provided a mechanistic explanation for the genesis of the High-ICR/Non-GIE subset.