Sample size and statistical power
psychotic symptoms, schizophrenia, anhedonia, psychosis
We will recruit approximately 60 patients with psychosis. However, currently there are no trials of immunotherapies for anhedonia in schizophrenia making accurate power calculation difficult. This study is a proof-of-concept experiment designed to test whether inhibition of IL-6 signalling leads to changes in psychotic symptoms. It could also inform likely statistical power for future trials testing efficacy of the drug as a treatment of schizophrenia, which is not the intention of this study. The exact statistical tests and techniques that will be applied to the data will depend on the objective of specific analysis and data characteristics (eg, variable type, distribution). These details will be specified in analysis plans and registered online before participants are unblinded and any data analysis is performed.