Study Treatment and Design
Toxicities
ADVERSE EVENT
The primary objective of this trial was to estimate the overall response rate (ORR) of olaparib in patients with Treatment cycles were 28 days. Patients were administered olaparib in tablet form orally 300 mg twice daily continually, irrespective of food intake. No premedications were required. Toxicities were graded using the NCI Common Terminology Criteria for Adverse Events version 5.0. Retreatment criteria can be found in Written informed consent was obtained from enrolled patients. Institutional Review Board approvals of the protocol and consent forms were obtained from all sites. Protocol design and conduct complied with all applicable regulations, guidance, and local policies. The study was conducted in accordance with the Declaration of Helsinki. The trial was conducted under an NCI-sponsored Investigational New Drug application (