The Dietary Intervention and VAScular function randomized controlled trial
cardiometabolic disease
ADHESION, DILATION, SECONDARY, INSULIN SENSITIVITY
A random selection of participants from each of the three intervention arms (broadly matched for age, sex, and BMI) from the DIVAS RCT with blood samples available at baseline and 16 wk post intervention was included in this secondary analysis (Preintervention characteristics and cardiometabolic disease risk markers in the subset of participants from the DIVAS randomized controlled trial (Abbreviations: AU, arbitrary unit; DBP, diastolic blood pressure; FMD, flow-mediated dilation; ICAM-1, intercellular adhesion molecule-1; LDI Ach, laser Doppler imaging microvascular response to acetylcholine; LDI SNP, laser Doppler imaging microvascular response to sodium nitroprusside; NOx, nitrogen oxides; PP, pulse pressure; QUICKI, quantitative insulin sensitivity check index; rQUICKI, revised quantitative insulin sensitivity index; SBP, systolic blood pressure; TG, triglycerides; VCAM-1, vascular cell adhesion protein 1.Upon inclusion, participants were randomly allocated to one of the three 16-wk isoenergetic, high-fat (36% TE) dietary intervention arms varying in proportions of SFAs, MUFAs, and PUFAs: a SFA-rich diet (target SFA:MUFA:n-6 PUFA ratio = 17:11:4 % TE), a MUFA-rich diet (target SFA:MUFA:n-6 PUFA ratio = 9:19:4 % TE), or a MUFA/PUFA-rich diet (target SFA:MUFA:n-6 PUFA ratio = 9:13:10 % TE) [