Metabolic pathways associated with treatment response
congenital adrenal hyperplasia
CONGENITAL ADRENAL HYPERPLASIA
All subjects in the MGTX study were on a standardized protocol of prednisone treatment at study entry. The alterations in metabolic pathways observed for treatment responsive subjects are consistent with the well-established effects of corticosteroids on protein metabolism, fatty acid metabolism, and de novo lipid biosynthesis [Corticosteroid treatment is known to induce protein catabolism in healthy adults and patients with SLE leading to increased plasma levels of amino acids [Glycosphingolipid (GLP) metabolism, urea cycle, and pentose phosphate pathways are associated with Several fatty acid and amino acid metabolites were identified as putative biomarkers in patients with congenital adrenal hyperplasia that were significantly altered in low versus high glucocorticoid dose studies [