Acknowledgements
The trial was funded by the NIHR Health Technology Assessment programme (project no. 06/78/03). The views and opinions expressed are those of the authors and do not necessarily reflect those of the Department of Health. A full list of local principal investigators and research professionals who supported the main trial can be found in Williams et al.[21] and we thank these individuals for their invaluable contributions. We are thankful to Professor Dyfrig Hughes for his comments on the earlier version of the manuscript. We also thank Dr. Morro Touray for his support in analysing QoL data during the project’s final report preparation at the University of South Wales. Open Access funding provided by the Qatar National Library.