Acknowledgements
The trial plan was approved by the ethics committee of the First Affiliated Hospital of Anhui Medical University (PJ2022-02-34). The study was registered in the Chinese Clinical Trial Registry (ChiCTR220055551, Principal Investigator: Y.L.) on 12 January 2022. Written informed consent was obtained from each patient in the study, which took place between 11 February 2022 and 20 June 2022. Y.S. and J.Z. contributed equally to this study.