Follow-up
During the hospitalization period, the medicines were administered to the patients by the nurses according to the clinicians’ prescriptions. The patients were followed up 24 h after being discharged from the hospital. They were also contacted on days 10, 15, 20, and 27 by the study team to assure that the patients had taken the medicines.Besides, the patients had access to the researcher in charge by phone calls to consult with her for any reason at any time. Trial completion was defined as consuming the nanomedicines for 28 days or discontinuation of the follow-ups for any cause.