Measurements
ARF, agitation, hypercapnia, cyanosis, instability - systolic blood pressure, respiratory distress
ARF, MINOR, RESPIRATORY ACIDOSIS, CARDIORESPIRATORY ARREST, CARDIAC ARRHYTHMIA, SECONDARY, LEAKAGE
The primary outcome was the incidence of ARF within 48 hours after extubation.
ARF is defined as the presence of at least two of the following criteria:
respiratory rate > 35 or < 12bpm; clinical signs of respiratory distress
(i.e., cyanosis, sweating, increased use of accessory respiratory muscles or
paradoxical breathing); hypercapnia associated with respiratory acidosis
(PaCOThe secondary exploratory outcomes assessed were reintubation rate 48 hours after
extubation and were based on one major criteria (cardiorespiratory arrest,
respiratory pauses with changes in state of consciousness, hemodynamic
instability - systolic blood pressure lower than 70mmHg -, cardiac arrhythmia
poorly tolerated) or two minor criteria (ventilation inefficiency due to
agitation or major leakage under NIV, respiratory rate > 35 breaths/min, pH
< 7.25 or PaOFinally, we recorded the evolution during the 4 preprogrammed sessions (Day 1 and
Day 2) of MRC and PCEF; the number of patients needing at least one airway
suctioning during the sessions, the number of patients needing at least one
additional session of physiotherapy and patient comfort. The baseline MRC score
was obtained as previously described, and the baseline PCEF was obtained
immediately after extubation and prior to the first intervention (i.e., Day 1).
Similarly, these parameters were assessed before the first session of each day
(i.e., Day 2) prior to each intervention. Medical Research Council was assessed
as described and validated previously,