2.9. Calculation of sample size
MISCARRIAGE
According to the medical records of tacrolimus-treated infertile patients from 2018 to 2019 at the Sugiyama Clinic, the proportions of positive hCG results at daily doses of tacrolimus 2, 3, and 4 mg were 44.4% (12/27), 58.8% (20/34), and 57.1% (8/14), respectively. The estimated proportions in the high-dose group in this trial were calculated from the proportion of 58.3% (28/48) in the combined 3 and 4 mg group. Since the miscarriage rate in the period between hCG positivity and fetal sac confirmation was 10.3%,