Concentrations of TFV, TAF, EVG and TFV-DP in vaginal tissue
As shown in Concentrations of EVG, TAF and TFV (ng/mg) and TFV-DP (fmol/mg) in vaginal tissue.*Means and Medians do not include BLQ values.Concentrations of Analytes in Vaginal Tissue. TFV was detected in vaginal tissue by 4 hours post-dose, and was higher at 24 hours post-dose (median 31.38 ng/mg). By 48 and 72 hours post dose, concentrations were similar to the 4 hour levels. Vaginal tissue TFV levels were detectable in all participants at all time points (Median vaginal tissue levels of EVG were slightly higher at 4 hours post-dose (median 17.75 ng/mg) relative to levels at 24 hours post-dose (median 15.79 ng/mg), and then markedly lower at 48 hours and 72 hours post-dose. EVG was detectable in all participants at all time points. All participants had vaginal tissue EVG concentrations above our Concentrations of TFV-DP were detected in vaginal tissue by 4 hours post-dose (median 156.80 fmol/mg) and were approximately 16-fold higher by 24 hours post-dose (median 2040.79 fmol/mg). TFV-DP concentrations decreased slightly (less than 2-fold) by 48 hours post dose and then were similar to the 24 hour level at 72 hours post dose. Vaginal tissue TFV-DP levels were detectable in all participants at all time points. Except at 4 hours post-dose (range 37.5-808.6 fmol/mg), median TFV-DP concentrations exceeded the target benchmark of 1000 fmol/mg of tissue at each of the subsequent time points including 72 hours post-dose. (