Target engagement: treatment-induced change in connectivity
In comparison with sham, active rTMS was associated with large connectivity changes in several of the a priori ROI pairs, including DMN to sgACC, Left to Right stimulation site, and Left stimulation site to sgACC. There were also large changes in within-ROI connectivity in both stimulation sites and sgACC (Fig. Results and statistical methods for exploratory analyses are detailed in the supplement. First, treatment-induced connectivity change was compared between active and sham groups. Partial Spearman correlation was computed between group and post-treatment connectivity after controlling for pre-treatment connectivity (Fig. 