Other clinical assessments
DISEASES
An improvement in diary symptom-specific score (DSSS) from baseline, Barthel index evaluating the activity of living with intractable diseases [Mean change from baseline in biomarkers of IFN signaling and IGS was assessed throughout the study. The IFN signature score used in IGS assessment, comprised of 6-gene IFN signature assays from 28 IFN Response Genes. The final assay was parameterized to separate IFN-high and IFN-low patients with a cut point of zero where each gene was scaled to have the same range. A change of 1 point in the IFN signature means twofold change in gene concentration.