Modulation of IFN-γ secretion and activation capacity of memory T cells after vaccination
IFN-γ secretion capacity of antigen-specific T cells can serve as a measure for a successful anti-viral immunityThe amount of IFN-γ secreted by the memory T cells obtained on day 7 after the vaccination was significantly higher than the placebo group. The highest levels of IFN-γ were detected in the co-cultures with TModulation of IFN-γ secretion and activation markers on memory T cell subtypes indicated the efficacy of whole virion vaccination on cellular immunity. TThe expression of CD25, CD38, 4-1BB, PD-1, and CD107a indicated the modulation of S1-specific CD4Collectively, in response to the S1-loaded mDC stimulation, the memory T cells collected on day 120 after the second CoronaVac dose secreted lower amounts of IFN-γ, and frequently upregulated the inhibitory receptor PD-1.