Sample Size and Statistical Analysis
The sample size was calculated based on the expected relative reduction (risk difference [RD]) in antibiotic prescription and the precision of the estimation of the measured reduction, at a 5% significance level and 80% power [Based on data collected in the field, the expected antibiotic prescription rate was 77% in the control group [Data analysis was performed using R version 4.2.1 (R Foundation for Statistical Computing, Vienna, Austria). For the quantitative data, the descriptions were performed by using means or medians accordingly. Absolute values and percentages were used to describe qualitative data.Primary outcome variables (clinical outcome after the follow-up visit by day 7 and antibiotic prescription; per protocol analyses) were compared between the intervention and routine arms in terms of both relative (risk ratio [RR]) and absolute (RD) effects, with 95% confidence intervals (CIs); numbers needed to test were calculated as 1/RD, with 95% CI. Fisher's exact test was used to compare proportions by estimating the 