Stepwise Logistic Regression for Death or Neurodevelopmental Impairment
death, NDI
Abbreviations: Csat, pretransfusion cerebral saturation; Hgb, hemoglobin.Additional adjustment factors in the final model along with center as a random effect.Post hoc exploration of predictors based on CART analysis was performed. Pretransfusion Csat less than 50% occurred in 15 infants. Six of these 15 were in the lower–Hgb threshold group for transfusion with mean (SD) Csat 38% (14%) while 9 were in the higher–Hgb threshold group with mean (SD) pretransfusion Csat 35% (13%). Mean study Hgb 12.5 g/dL or greater occurred in 22 infants, 17 of whom (77%) had the adverse outcome of NDI or death. These 22 infants did not have significantly different mean pretransfusion Csat compared to the 75 infants with Hgb less than 12.5 g/dL (mean [SD], 63% [19%] vs 61% [13%]). However, they were more likely to have received extra transfusions outside of study protocol (mean [SD], 9 [3] vs 2 [1]; 