CONCLUSIONS
macrovascular or microvascular function, inflammation
INFLAMMATION
In conclusion, our findings showed that 10 days of melatonin supplementation (10 mg/d) did not improve macrovascular or microvascular function compared to a placebo and did not decrease ROS in our sample of young healthy normotensive adults consuming a HSD. Future studies should investigate different melatonin doses and durations, explore mechanisms beyond ROS formation, such as inflammation and antioxidant defense systems, and examine other populations.