References
Dry eye disease, visual loss, dryness, HAT
CONJUNCTIVA
The fingerprint chromatogram of the anthocyanins in the functional soup containing “Anthaplex” at the doses of 2 g (Schematic diagram of the experimental procedures.The contents of various forms of anthocyanins in the functional soup containing “Anthaplex” at the doses of 2 g and 4 g/serving, respectively.Dry eye disease severity grading scheme according to the modified method of Messmer.+/−: irreversible change of conjunctiva without permanent visual loss, +/+++: irreversible change of conjunctiva with permanent visual loss. ↓: decrease.Demographic data of subjects before the intervention. Data were presented as mean ± SEM (D2, D4: The function soup containing “Anthaplex” at the doses of 2 g and 4 g per serving.Demographic data of subjects after an 8-week consumption period of the functional soup containing “Anthaplex” at the doses of 2 g and 4 g per serving. Data were presented as mean ± SEM (D2, D4: The function soup containing “Anthaplex” at the doses of 2 g and 4 g per serving. ** Effect of the functional soup containing “Anthaplex” at the doses of 2 g and 4 g per serving on the latency and amplitude of N100 and P300 waves of event-related potential at an 8-week consumption period (D2, D4: The function soup containing “Anthaplex” at the doses of 2 g and 4 g per serving. ** Effect of the functional soup containing “Anthaplex” on working memory assessed by using event-related potential. (D2, D4: The function soup containing “Anthaplex” at the doses of 2 g and 4 g per serving. (Severity score of eye dryness via the modified criteria of Messmer (2015) by physician. Data were expressed as mean ± SEM. (D2, D4: The function soup containing “Anthaplex” at the doses of 2, and 4 g per serving. # The effect of the functional soup containing various doses of “Anthaplex” on acetylcholinesterase (AChE), monoamine oxidase, monoamine oxidase type A and type B (MAO-A, MAO-B), GABA transaminase (GABA-T) and brain-derived neurotropic factor (BDNF). Data were expressed as mean + SEM). (D2, D4: The function soup containing “Anthaplex” at the doses of 2, and 4 g per serving.The effect of the functional soup containing various doses of “Anthaplex” on feces pH, amount of lactic-acid-producing bacteria, and the amount of both D2, D4: The function soup containing “Anthaplex” at the doses of 2, and 4 g per serving.The effect of the functional soup containing various doses of “Anthaplex” on short-chain fatty acids (SCFA) consisting of acetate, propionate, and butyrate. Data were presented as mean ± SEM. (D2, D4: The function soup containing “Anthaplex” at the doses of 2 g and 4 g/serving.The effect of the functional soup containing various doses of “Anthaplex” on histone acetyltransferase (HAT), histone deacetylase (HDAC), and DNA methyltransferase (DNMT). Data were presented as mean + SEM. (