Antibodies 2C06 and 2C09 form a reproducible antibody class
Antibodies 2C06 and 2C09 originated from similar heavy-chain variable genes, IGHV3-64D and IGHV3-64, respectively (The similarity in origin genes and in Env-trimer recognition suggested that 2C06 and 2C09 might be members of a reproducible antibody class. Indeed, most residues involved in trimer binding were identical between 2C06 and 2C09, discounting the different length in CDR H3. Both 2C06 and 2C09 also showed low levels of somatic hypermutation (1% and 3%, respectively, based on nucleotide sequence) (To confirm whether 2C06 and 2C09 were members of the same antibody class, we swapped the heavy and light chains of the two antibodies, as such swapping has in the past confirmed class membership.