Conclusion
sleep disturbance, cognitive impairment, sleep disturbances, neurocognitive toxicity, cognitive dysfunction, neurotoxicity, depression
HIV INFECTION, EVENTS, PERIPHERAL NEUROPATHY
In our study, there was no evidence of an association between timing of initiation of IPT during antepartum and postpartum, concomitant use of EFV and increased frequencies of probable depression, cognitive dysfunction, sleep disturbances or peripheral neuropathy. Symptoms of neurotoxicity peaked at 12 weeks but was not higher compared to historical controls of post-partum women without HIV infection. Further study is advised to formally assess associations of risk factors for neurotoxicity.Verbal screening for symptoms of neurocognitive toxicity is not costly and readily integrated with maternity services. Identifying the small percentage of women with moderate to severe depression and significant sleep disturbance or cognitive impairment is important in preventing the catastrophic events of poor mother-infant bonding and the adverse child development associated with maternal neurocognitive toxicity.