Creatine kinase (
muscle injury, muscle cell necrosis, Clarkson et al.,, muscle cell disruption, tissue damage, myopathies
CELL DAMAGE, DISEASE, MYOPATHIES
CK is a compact enzyme that is found in both the cytosol and mitochondria of tissues where energy demands are high. Raised levels of serum CK are still closely associated with cell damage, muscle cell disruption, or disease. These cellular disturbances can cause CK to leak from cells into the blood serum. Measurement of serum CK activity and determination of isoenzyme profiles are important indicators of occurrence of muscle cell necrosis and tissue damage. Serum CK is the most diagnostically sensitive test for muscle injury and myopathies (Clarkson et al., 