Discussion
residual neuromuscular blockade
NEUROMUSCULAR BLOCKADE
In this study, the planned incorporation of flumazenil in remimazolam-based TIVA led to a significantly faster recovery of consciousness with less variation than that with propofol, and it may be used to mitigate delayed recovery reported in previous studies [When investigating the effect of flumazenil on consciousness recovery time following remimazolam use, some considerations should be kept in mind. First, residual neuromuscular blockade can cause discomfort in patients who recovered consciousness quickly by flumazenil and may have affected our primary outcome. Therefore, we tried to maintain a moderate degree of neuromuscular relaxation during surgery and used sugammadex to avoid residual neuromuscular blockade [One study found that the use of flumazenil led to faster recovery following remimazolam-induced sedation compared to that following the use of a placebo [Despite our best efforts, this study had some limitations. First, we could not compare the differences in the recovery speed of remimazolam with or without the administration of flumazenil. The IRB of our institution pointed to previous studies already demonstrating that the administration of flumazenil accelerates recovery speed with remimazolam-based TIVA [