3.7. Subgroup Analysis for PFS and OS in the cfDNA BEP
LIVER METASTASIS
In the univariate analysis for the PFS, female patients, liver metastasis, EGFR mutation, low or no PD-L1 expression, cfDNA concentration at C0, dynamic change of bTMB, hVAF, and VAFSD were associated with worse outcomes (A multivariate analysis of the PFS revealed that increased bTMB from C0 to C4 (C4/C0 > 1; hazard ratio (HR): 4.95, 95% CI: 1.63–15.07) and a high cfDNA concentration at C0 (HR: 5.16, 95% CI: 1.73–15.37) were significant risk factors (In the multivariate analysis for the OS, a high VAFSD at C0 (HR:2.84, 95% CI: 1.24–6.50) was confirmed as an independent prognostic factor for the OS (