Introduction
type 2 diabetes mellitus, Diabetes mellitus
EPIDEMIC DISEASE, TYPE 2 DIABETES MELLITUS, DIABETES MELLITUS
Diabetes mellitus is an epidemic disease affecting more than 460 million people worldwide [The specific mechanisms mediating the beneficial effects of empagliflozin on cardiovascular outcome remain controversial [The EmDia trial was designed to evaluate the effect of empagliflozin compared to placebo on left ventricular diastolic function in subjects with type 2 diabetes mellitus and elevated left ventricular end-diastolic pressure in a randomized, double-blind controlled clinical trial combined with comprehensive clinical and molecular phenotyping.