INTRODUCTION
infectious diseases, infection
INFECTIOUS DISEASES, VIRUS, DISEASE, SEVERE ACUTE RESPIRATORY SYNDROME, INFECTION, CORONAVIRUS, DISEASES
For infectious diseases where immunization offers lifelong protection the sufficiency of vaccines as a sole effective control method is obvious, however for many diseases caused by respiratory virus, including severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection, immunity wanes over time after vaccination.SARS‐CoV‐2 immunopathogeny hits precisely at this sensitive point. Two main obstacles hinder a correct immune surveillance of SARS‐CoV‐2 by the immune system, lung structure itselfChildren and young adults experience less severe COVID‐19 than aged people because among other causes they have a basal preactivated innate immunity which protect them from severe disease.The investigators wondered whether it would be possible to counter SARS‐CoV‐2 ability to silence the immune surveillance function played by innate immunity by local oromucosal immunomodulation with high polyphenolic olive oil. Immunomodulation of local immune response at the buccopharyngeal mucosa could hypothetically activate mucosal immunity, which can prevent SARS‐CoV‐2 main immune evasion mechanisms in early stages of the disease. Olive polyphenols are well‐known, pharmacologically active compounds with immunomodulatory activity.