Planned final analyses
The primary analysis for the trial will occur once all participants have either fulfilled the near FH definition (growth rate of < 2 cm/year and have reached a bone age of 14 years (females) or 16 years (males)), have completed the 36-month assessment or have withdrawn from the study or been lost to follow-up and corresponding outcome data have been entered onto the trial database and validated as being ready for analysis. All other outcome measure analyses will be undertaken when the final participant (as defined above) reaches their 36-month assessment.