Methods in analysis to handle protocol non-adherence and any statistical methods to handle missing data {20c}
FCS
ACUTE LEUKEMIA
To prevent attrition bias, two types of analysis will be performed: an intention-to-treat analysis, in which all randomized patients will be analyzed according to the group to which they were randomized, regardless they received the assigned treatment or not, and, in addition, a per-protocol analysis will be performed in all randomized patients who finally received the assigned treatment for at least of 24 h (2 doses of ciprofloxacin and 3 doses of fosfomycin).The imputation of missing variables will consider the distribution of the variables, the allocation group, the center, and the baseline condition (acute leukemia or stem cell transplant).The method of fully conditional specification (FCS) using the MI procedure of SAS, version 9.4 (SAS Inc, Cary, NC, USA), will be used [