Introduction
STOP-PD, non-psychotic depressed, psychotic depression, Psychotic Depression, Psychotic, hallucinations, depressive disorder, delusions, MDD
MRS
Psychotic features, such as delusions and hallucinations, occur in up to 20% of patients with major depressive disorder (MDD) (Coryell et al., Previous MRS studies indicate that non-psychotic depressed patients have lower levels of choline in the left dorsolateral prefrontal white matter (Wang et al., In relation to the treatment, Chen et al. found that Glx, Patients with psychotic depression commonly receive treatment with a combination of antidepressant and antipsychotic medication, which complicates the interpretation of MRS studies because antipsychotic medications may affect neurometabolites. Studying participants in the presence and absence of antipsychotics is critical for disambiguating the effects of illness versus antipsychotics on metabolite levels. Moreover, antidepressant mechanisms of action may interact directly or indirectly with antipsychotics. It may also provide new insights into the mechanisms of action of antipsychotic medications in individuals with psychotic depression.The multi-center Study of the Pharmacotherapy of Psychotic Depression (STOP-PD) II randomized controlled trial (RCT) (Flint et al., 