2.1. Study Design and Participants
SECONDARY, WHITEHEAD
This study, designed as a quasi-randomized pre/post-controlled trial, targeted patients with secondary progressive MS. Following the participant enrollment guidelines established by Julious (2005) and Whitehead et al. (2015) [The protocol, aligned with the principles of the Helsinki Declaration, was reviewed and approved by the Institutional Review Board of San Camillo Hospital (Venice, Italy) under reference number “protocollo 2018.01”. All participants provided written informed consent to partake in the research.