Heatmap Representing the Different Distributions of the CIBERSORT-Derived Gene Expression Signatures by Tumor-Infiltrating Lymphocyte (TIL) and Immunoglobulin G (IgG) Levels
Leukemia, Cancer
GROUP B, LEUKEMIA, CANCER
Cancer and Leukemia Group B 40601 (CALGB 40601) and PAMELA trial samples were classified into 3 different groups by study, depending on the TIL and IgG levels by tertiles (ie, low, medium, and high TILs; and low, medium, and high IgG). Then, a multiclass significance analysis of microarrays was performed. The standardized mean differences between the immune signatures in 1 class vs the overall mean expression for each study are represented in 4 heatmaps. NK indicates natural killer; T regs, T regulatory cells.