References
high-density lipoprotein
Flowchart diagram of the study population in the different phases of the study. A total of 200 subjects were screened for eligibility. In total, 66 subjects had to be excluded, so that 134 subjects were randomized to the four diet groups. After completion of the study, sorted by group, 27, 27, 23 and 28 participants were included in the statistical analysis.Study design of the KoALA study. Abbreviations: ARA, arachidonic acid; LA, linoleic acid; MUFA, monounsaturated fatty acids; PUFA, polyunsaturated fatty acids; SFA, saturated fatty acids.Plots (Fatty acid distribution of the provided linseed oil expressed as fatty acid methyl esters (FAME).Abbreviations: MUFA, monounsaturated fatty acids; FAME, fatty acid methyl esters; PUFA, polyunsaturated fatty acids; SFA, saturated fatty acids.Characteristics of the study collective—baseline assessment.Variables expressed as mean (±SD) or as median (25th, 75th percentile) depending on the data distribution. Abbreviations: BMI, body mass index; HDL, high-density lipoprotein; LDL, low-density lipoprotein.Sex distribution and age per group—baseline assessment.Variable expressed as mean (±SD) and/or as median (25th, 75th percentile) depending on the statistical test that was performed; groups without a common letter are significantly different, Comparison of percentage change from baseline within diet groups split in dependence of sex, EPA baseline status, and LA change over the intervention period.* Variables expressed as mean (±SD) and/or as median (25th, 75th percentile) depending on the statistical tests that were performed; ∆ comparison of subgroups within diet groups; ◊ comparison of subgroups between diet groups, groups without a common letter are significantly different, Fasting biochemical parameters and anthropometric measurements at baseline (week 0) and at the end of the intervention period (week 12).* Variables expressed as mean (±SD) and/or as median (25th, 75th percentile) depending on the statistical tests that were performed; ◊ groups without a common letter are significantly different, 