Animal models and treatments
IUA
A total of 32 female adult SPF BALB/C mice (HUNAN SJA Laboratory animal co., LTD), weighing 22–26 g and aged 6–8 weeks, were employed in this experiment. The mice were placed in a clean, cozy, air-conditioned space with unrestricted access to food and drink. The temperature, lighting, noise, ventilation and other conditions of the observation room are controlled within the specified range. After one week of adaptation, 32 mice with similar body weight and strong adaptability were selected and divided into 3 groups, including the control group (C, n = 8) and 2 experimental groups (n = 12 per group). These experimental groups were divided into M (model of IUA) and L (IUA + After adaptation, the IUA model of mice in all experimental groups was established by using the same mechanical injury method as Yang Huan’s [