Mobilization of bone marrow stem cells and progenitor cells to the peripheral blood
In the mid-dose group (0.01 mL/kg), after administration of MRG-001, CD45Stem cell mobilization with MRG-001Subjects received SC injections every other day of saline (placebo control), mid-dose (0.01 mL/kg), or high-dose (0.02 mL/kg) MRG-001 (n = 4/group). Venous blood was collected and PBMCs were isolated at different time intervals on day 1 after a single dose SC injection of saline or MRG-001 and on day 5 after the third dose. Stem cell populations (CD45(A) Stem cells in peripheral blood on day 1 after a single dose SC injection of saline or MRG-001.(B) Stem cells in peripheral blood on day 5 after the third dose. Each value represents the mean ± SD.Yellow marked cells represent significant difference with p < 0.05.After administration of the third dose at day 5, MRG-001 consistently mobilized stem cells and progenitor cells in a similar pattern (