2.3. Statistical Method
HYPERGLYCEMIA, HYPOGLYCEMIA
The metrics selected to assess the glycemic outcome after applying the proposed method were as follows: (1) time in range (TIR), defined as the percentage of time spent within the range of 70–180 mg/dL; (2) time above range (TAR), i.e., hyperglycemia, defined as the percentage of time spent above 180 mg/dL; (3) time below range (TBR), i.e., hypoglycemia, defined as the percentage of time spent below 70 mg/dL; (4) the percentage of time spent below 50 mg/dL; and (5) the percentage of time spent above 300 mg/dL.A normal Q-Q plot and Shapiro–Wilk tests were applied to verify if the percentage values obtained in the experiments followed the normal distribution. As the data did not follow the normal distribution, we decided to use the bootstrap method instead of the central limit theorem because of the small number of patients in the study. Moreover, CIs and hypothesis tests for the difference between the means, using the nonparametric bootstrap method, were used to compare the results of each experiment (E