Study population
angina, stroke, heart failure symptoms, hepatic or renal impairment, acute coronary syndrome, rhythm abnormalities, depression, RA, T2DM
BRUCE, UNCONTROLLED HYPERTENSION, TRANSIENT ISCHEMIC ATTACK, STROKE, STD, ACUTE CORONARY SYNDROME, HEART, LEFT BRANCH BUNDLE BLOCK
Participants were included if they were aged over 18 with concurrent T2DM and CADs. Moreover, key inclusion criteria were as follows: (1) baseline AF score of ≤90 on SAQ, (2) treatment with at least three antianginal medications for more than 3 months, (3) unsuitable candidates for revascularization procedures (either percutaneous coronary intervention or coronary artery bypass grafting), (4) reproducible angina with concomitant ischemic ST‐segment depression of at least 1 mm on the electrocardiogram (ECG), (5) restricted treadmill testing exercise capacity (3–9 min on a modified Bruce protocol) at baseline.Key exclusion criteria initially included: (1) New York Heart Association (NYHA) functional class of III–IV, (2) presence of heart failure symptoms, (3) an acute coronary syndrome in the past 2 months, (4) any coronary revascularization during the study period, (5) the occurrence of stroke or transient ischemic attack within 6 months of screening, (6) uncontrolled hypertension, (7) clinically significant hepatic or renal impairment, (8) prior treatment with empagliflozin, (9) recent use of invasive treatments for RA (including the EECP), extracorporeal shockwave therapy, coronary sinus reducer implantation, spinal cord stimulation, or sympathectomy), (10) any relative or absolute contraindications for the exercise test, (11) specific conditions that may preclude the accurate interpretation of ECG (such as left bundle branch block, resting ST depression (STD) more than 1 mm, pre‐excitation rhythm abnormalities or usage of Digoxin).