Statistical analysis
A “Rolling 6” design was adopted in this dose‐escalation study, with up to six evaluable patients enrolled in each dose group. The total number of participants was contingent on the number of dose‐escalation groups.Statistical analyses primarily utilized descriptive statistics. Continuous variables were presented as mean ± standard deviation or median (range) depending on the normality of the data. Categorical variables were presented as frequency (percentage). The 95% confidence intervals (CIs) for the ORR and DCR were calculated using the Clopper–Pearson method. The Kaplan–Meier method was employed to estimate the medians and 95% CIs of PFS and DoR. Statistical analyses were conducted using SAS version 9.4 (SAS Institute, Cary, NC, USA).