In situ immune modulation and cytokine modulation in peripheral blood
tumor, cancer lesions
TUMOR, INFILTRATION
Patient 01, who had worsening contrast enhancement, underwent resection 6 weeks after infusion, providing us with an opportunity to explore the pathological status and immune microenvironment of the tumor. We detected the expression of GD2 antigen and infiltration of immune cells in the cancer lesions. Interestingly, we found that GD2 expression dramatically decreased after infusion (Fig. 
Immune modulation after GD2 specific 4SCAR-T cell infusion. In addition, we measured circulating IL-6 and TNFα levels in the peripheral blood of the other seven patients infused with 4SCAR-T cells. All patients had elevated levels of IL-6 and TNFα in the peripheral blood after 4SCAR-T cell infusion (Fig. 
Cytokine modulation in peripheral blood after GD2 specific 4SCAR-T cell infusion. (