Statistical analysis
The data were presented as a median with a quartile range due to significant deviations from the normal distribution assessed using the graphical method with the analysis of the histogram and the Q-Q plot. Due to significant deviations from the normal distribution, the dependence of the studied variables on time and between groups was performed based on the nparLD test, which is a non-parametric equivalent of the analysis of variance for repeated measurements. The Kruskall-Wallis test with the post-Hoc multiple comparison test was used to compare the baseline values of the parameters studied with the control group. Comparisons between the control group and the total study group were made using the U-Mann Whitney test. The values of 