References
cutaneous primary somatosensory neurons
COLD
A schematic representation of the CONSORT flow diagram of the protocol and a detailed description of the study in healthy human subjects.A conventional schematic of the study protocol procedure to assess the efficacy of the proprietary HEPT7G/βCD inclusion complex on the peripheral skin temperature and blood flow during cold-stimulate stress and subsequent recovery after cooling stress in healthy human subjects.The skin peripheral temperature and blood flow profiles of the study subjects just before the cold-stimulate stress ((The skin peripheral blood flow and temperature profiles of the study subjects during rewarming (recovery) after cold−stimulate stress in healthy human subjects. The bar plot of mean ± SEM values of profiles is presented for the placebo, high−dose (HD), and low−dose (LD) HEPT7G/βCD inclusion complex intake groups. ((An overview of thermosensation and molecular response mechanisms. The cutaneous primary somatosensory neurons (C-fibers and Aδ-fibers) enact the cold sensation responses at thermal thresholds and thermos-neutral skin temperatures. HEPT7G/βCD inclusion complex intake modulates the balance between vasoconstrictor and vasodilator for improved peripheral blood flow.Characteristic features and blood biomarker details of the study subjects at baseline.Significance A non-parametric Friedman rank test with repeated measures followed by post-hoc pairwise comparison using the Durbin–Conover test revealed a significant overall difference in peripheral skin finger blood flow (mL/min) during the temperature recovery among the HEPT7G/βCD inclusion complex treatments compared to placebo.† Pairwise comparison (between groups); * significance A non-parametric Friedman rank test with repeated measures followed by post-hoc pairwise comparison using the Durbin–Conover test revealed a significant overall difference in peripheral skin finger temperature (°C) during ambient rewarming (recovery) among the HEPT7G/βCD inclusion complex treatments compared to placebo.† Pairwise comparison (between groups); ** highly significant Subjective questionnaire scores († Pairwise comparison (between groups); * significance 