Introduction
daytime sleepiness, MS-related fatigue, fatigue, Fatigue
MULTIPLE SCLEROSIS (MS)
Fatigue is a highly prevalent and burdensome symptom in multiple sclerosis (MS). MS-related fatigue can be effectively treated with cognitive behavioural therapy (CBT).Little is known about the mechanisms involved in the relapse in fatigue over time after CBT. Mediation analysis showed that increased daytime sleepiness, more problems in staying physically active and an increase of subjective cognitive problems mediated relapse in fatigue following CBT in patients with MS.Although offering booster sessions has been suggested as a way to improve sustainment of treatment effects, few studies report on their effectiveness. Effectiveness of boosters varies between studiesThe aim of the present RCT was to study whether a booster programme improves the outcome of CBT for MS-related fatigue at 1-year follow-up.