Author contributions
AT, KP, KR, EK, OK, OK and LAA conceived the ideas and planned the experiments. AT, KP, KR, EK and LAA interpreted the data and wrote the manuscript. OK and OK characterized patient samples. AT and KP performed methylation analyses. AT and AK analyzed differential gene expression. EK, AT and AK performed deconvolution analysis. NV preprocessed the RNA-sequencing data. All authors read and approved the final manuscript.