Effects of CBD on the endocannabinoid system in psychiatric disorders
psychiatric
DISORDERS
The body of evidence discussed thus far implicates the endocannabinoid system in a range of psychiatric disorders where CBD may have therapeutic potential. It is therefore plausible that the therapeutic effects of CBD occur, at least in part, through its actions on the endocannabinoid system. CBD may act on the endocannabinoid system through several means: by inhibiting lipoxygenases involved in anandamide degradation; [Although this preliminary evidence indicates an effect of CBD within the endocannabinoid system, our mechanistic understanding of this pathway is impeded due to methodological limitations of the current literature. While animal studies offer insight into the preclinical pharmacology of CBD, it remains to be seen whether CBD causes the same effects in humans. While Leweke et al. [