Methods for additional analyses (e.g., subgroup analyses) {20b}
AKI, renal damage, nephropathy, liver disease
REGRESSION, SECONDARY, NEPHROPATHY, LIVER DISEASE
The primary endpoint will be analyzed in a secondary analysis based on the intention to treat principle using a Cox regression (with centers, presence/absence of intrinsic renal damage as determined by plasma and urine biomarkers, etiology of the underlying liver disease (alcoholic versus non-alcoholic) and impact of the presence of intrinsic nephropathy as assessed by cystatin C and UnGAL as fixed effects) adjusted for AKI stage. These effects will be checked with BIC (Bayesian information criterion). In case of significance, results will be interpreted in an exploratory manner.