Intervention and control
PFO
In the PFOC-RE trial, participants will be randomized to the intervention and control groups. The participants in the intervention group will undergo PFO closure and receive antiplatelet therapy for 24 weeks. Postoperative antiplatelet therapy involves two stages: a daily medication regimen with 75 mg of clopidogrel and 100 mg of aspirin from the first to the twelfth weeks, and a daily medication regimen with 100 mg of aspirin from the thirteenth to the twenty-fourth week. In contrast, the control group will only receive antiplatelet therapy for 24 weeks, which is consistent with the medication regimen in the intervention group.