Results of the two-sample mendelian randomization analysis
PD, CAD, stroke
STROKE, CAD
In the analysis, we used 23 SNPs that had substantial associations with PD (By utilizing the merging tool to find 20 SNPs in the CADs GWAS data, we then eliminated two palindromic SNPs (rs10451230, rs823106) so that only 18 SNPs were included in the final MR analysis. According to our primary IVW analysis, PD is linked to a higher incidence of CAD (OR = 1.055, 95% CI 1.020–1.091, Forest plot for MR detection.((We found 23 SNPs in the stroke and its subgroups GWAS date by using the merge function and then removed one palindromic SNP (rs10451230), such that 22 SNPs were included in the final MR analysis. According to the MR test scatter plots shown in Fig. In our study, 20 SNPs, 22 SNPs, 16 SNPs, and 22 SNPs were included in the MR analysis of MI, AF, HF, and LAS, respectively, and the results of the IVW analyses suggested that there was no causal relationship between PD and the incidence of MI (OR = 0.984, 95% CI 0.950–1.020,