Materials and methods
lung cancer
LUNG CANCER
This study is an extension of the NELSON trial with focus on personalized outcome prediction (NELSON-POP). New data will be derived for the NELSON study that have thus far not been considered in predicting lung cancer and survival. Based on already available and these new data, multi-source prediction models for pre-screening and post-baseline-screening participant selection and nodule discrimination will be developed to enable personalized screening strategies (Fig. 
Screening strategy: top: current strategy, with same screen procedures for each screenee, and bottom: personalized approach implementing the multi-source data