Sensitivity analyses
All results obtained after applying the soft criteria and no criteria are reported in the Supplementary Material: dimension-level response patterns (SM3); change scores for ‘improved’ and ‘not improved’ groups, by anchor (SM4); descriptive statistics (SM5); and AUC analysis (SM6). There were no directional inconsistencies in the comparisons of group means. Statistically significant differences were observed in 56 (of 66) analyses using the soft data quality criteria and 55 when using no data quality criteria; in both instances, the Brief Substance Craving Scale anchor accounted for five of the non-significant comparisons. Unlike analyses under the strict data quality criteria, there were statistically significant differences between change scores. The mean HUI3 change score from baseline to 24 weeks was significantly higher than the mean EQ-5D-3L and EQ-5D-5L change scores under the soft criteria, and significantly higher than the mean EQ-5D-3L change score when applying no criteria. Regarding AUC estimates, no ‘high’ classifications were observed in the sensitivity analysis. The number of ‘moderate’ classifications was lower in the sensitivity analyses compared with the strict data criteria for the EQ-5D instruments, and higher for the HUI3. Similar to the strict data criteria analysis, no single instrument dominated the highest 10 AUC estimates.