Competing interests
At the time of this research, AY was an employee of QualityMetric, which received payment from Ionis Pharmaceuticals Inc., to conduct these analyses and develop this manuscript; AY is currently an employee of and owns stock in Ionis Pharmaceuticals Inc. AL is an employee of QualityMetric. DB and MVL are employees of and own stock in Ionis Pharmaceuticals Inc. SK has received consulting honoraria from Ionis Pharmaceuticals, Akcea Therapeutics, Alnylam, Pfizer, and Eidos. CK has received consulting honoraria from Ionis Pharmaceuticals, Akcea Therapeutics, Argenx, CSL Behring, Alnylam, Biogen, and Sanofi.