Funding
This study was funded by by National Natural Science Foundation of China (No. 82171176 and No. 82001424), the Natural Science Foundation of Zhejiang Province (grant number: LZ19H090003, LQ23H090015), the Health Commission of Zhejiang Province (grant number:2021KY176) and registered at Chinese Clinical Trial Registry (ChiCTR2000040344; November 28, 2020).