Design and participants
WL
MINOR
The Personalized Nutrition Study (POINTS, ClinicalTrials.gov identifier: NCT04145466) was a 12-week, single-site, parallel-arm WL trial that was approved by the institutional review board (IRB FWA 00006218) of the Pennington Biomedical Research Center (PBRC, Baton Rouge, LA). Participants were enrolled between October 7, 2020 and September 8, 2021. Participants were identified a priori as carbohydrate-responders and fat-responders based on their combined genotypes at 10 genetic variant loci and randomized to either a high-carbohydrate or high-fat diet, yielding the following groups: (1) fat-responders receiving a high-fat diet, (2) fat-responders receiving a high-carbohydrate diet, (3) carbohydrate-responders receiving a high-fat diet, and (4) carbohydrate-responders receiving a high-carbohydrate diet.Participants were recruited from the community. Eligible participants were 18–75 years old, had a BMI of 27.0–47.5 kg/mThe study included 1 orientation visit, 2 clinic visits (one before and one after the intervention), and 12-weekly intervention sessions. All participants provided written informed consent, and participants who completed the study received a minor compensation of $150.