Quality of life (EQ-5D questionnaire)
depression, Diabetic, anxiety, pain
Patients with CLTI treated with auto-BM-MNC or allo-WJ-MSCs presented an enhancement of their life quality, as shown by the data of the EQ-5D profile (Fig. Diabetic patients with CTLI improved their quality of life after the treatment with auto-BM-MNC or allo-WJ-MSCs. The improvement in EQ-5D was primarily due to the following dimensions: mobility, physical functioning, usual activities, self-care, pain, and no anxiety or depression.All participants reported satisfaction with the results of cell-based therapy and recognized that the pain relief of their treated leg enabled them to enhance their usual activity level, including walking and presenting a significant reduction in the use of analgesics. Additionally, the EQ-5D score revealed stabilization or improvement of symptoms compared to the placebo group during the follow-up. Furthermore, the self-assessed measure of overall health (visual analog scale (EQ-VAS)) showed improvements in patients’ health problems from treatment (Fig. 