Results
HEART
The baseline clinico-electrocardiographic characteristics of healthy volunteers administered halofantrine alone or with either fluconazole or kolanut as shown in Baseline clinico-electrocardiographic characteristics of healthy volunteers administered halofantrine alone or with either fluconazole or kolanutP < 0.05 for halofantrine group versus halofantrine and kolanutThe plasma levels of potassium, sodium, creatinine, and the liver enzymes in the three groups were within the reference intervals at baseline, Baseline biochemical parameters of healthy volunteers administered halofantrine alone or with either fluconazole or kolanutBaseline electrocardiographic intervals significantly correlated with 6-hour values.Heart rates (beats/min) and RR interval (msecs) are shown on Heart rate (/min.) of study participants on halofantrine alone or in combination with kolanut or fluconazoleRR interval (msec) of study participants on halofantrine alone or in combination with kolanut or fluconazoleEight individuals, halofantrine group (2), halofantrine and kolanut group (1), and halofantrine and fluconazole group (5), had pre-treatment PR interval more than 200 msec though they had no clinical symptoms; 5 individuals had PR interval prolonged at 6-hour, same number in the halofantrine and halofantrine kolanut group, but less number, 3 in the halofantrine plus fluconazole group. PR interval, PR interval (msec) of study participants on halofantrine alone or in combination with kolanut or fluconazoleThe QRS duration (msec) and QT interval (msec) are shown on QRS duration (msec) of study participants on halofantrine alone or in combination with kolanut or fluconazoleQT interval (msec) of study participants on halofantrine alone or in combination with kolanut or fluconazoleQTc was derived from Bazzett's formula QT/√RR. There was prolongation of QTc (384.76 21.727 to 394.12 21.525; 381.36 22.29 to 388.30 17.26 and 382.35 20.08 to 390.84 21.97 msec) in all the three treatment groups at 6 hours but were not statistically significant, QTc interval (msec) of study participants on halofantrine alone or in combination with kolanut or fluconazoleThough no patient had QTc prolongation greater than 440 msec pre-treatment, it occurred in one patient on halofantrine and fluconazole at 6 hours, and in another on Day 14. Pre-treatment PR interval (PR 