Cross-sectional baseline brain metabolite levels in patients versus controls
CORTEX, MRS
The flow diagram of the participants included in this study is presented in Figure Characteristics of the participants at the baseline scanValues are shown as N (%) or mean ± SD (range). Notes. a, Mann–Whitney U test was applied; b, for participants with complete longitudinal MRS scans only; c, item7 excluded; d, Fisher’s exact test was applied; e, Abbreviations. Site-specific data are presented in Table Meta-analysis of metabolite levels in the dACC in patient versus control groups. Mean metabolite levels are estimated marginal means controlled for age and sex. A positive standardized mean difference indicates higher metabolite levels in patients compared to controls. Abbreviations. Cho, glycerophosphocholine + phosphocholine; Cr, creatine + phosphocreatine; dACC, dorsal anterior cingulate cortex; Glx, glutamate + glutamine; mI, myo-inositol; RE, random effect; SD, standard deviation; tNAA, 