Limitations
One of the limitations of this study was that we could not use APG continuously due to the short life span of platelets at room temperature, and for optimal healing effect, it should be prepared fresh. In addition, further trials are needed to confirm our preliminary findings by increasing the patient number and the duration of treatment and by eventually adding a second clinical design by comparing three lesions in one patient, one treated with topical SbV first and with APG-GF thereafter and the second lesion with APG-GF first, and with topical SbV only, if there is insufficient healing after 8 weeks.