Conclusion
We characterized effects of different intravenous DMT administration regimens to support dose finding for research and psychedelic-assisted therapy in future studies. DMT produced rapid and intense short-lasting and moderately well-tolerated psychedelic effects when dosed as a bolus, and it induced stable, intense, and well-tolerated effects when used as a infusion. Intravenous DMT administration, particularly as an infusion, may be used as a pharmacological tool to rapidly induce, maintain, and end a psychedelic state in a highly controlled manner. Thus, a psychedelic experience can be tailored to the specific needs of patients and therapeutic settings.