Outcome measures
neurologic deterioration, death, liver and kidney function, HT
ADVERSE EVENTS
The study primary endpoints were any and symptomatic HT verified on a follow-up CT scan from day 0 to day 14. Symptomatic HT was defined according to the ECASS III trial: any apparently extravascular blood in the brain or within the cranium that was associated with clinical deterioration, as defined by an increase of 4 points or more in the score on the NIHSS, or that led to death and that was identified as the predominant cause of the neurologic deterioration [Secondary endpoints were the functional outcome measured with the NIHSS and mRS as well as drug safety. Favorable functional outcome was defined as the mRS score of ≤ 2 on day 90. The NIHSS score on day 14 was considered as a marker of short-term neurological recovery [From day 0 to 14, patients in both arms were monitored for any adverse events (AE), including changes in vital signs, general and neurological condition, electrocardiogram, and routine laboratory tests (liver and kidney function tests, complete blood count). In case an AE occurred, the decision to withdraw participants from the study was bestowed upon investigators.