Outcomes
dysphoria
Our primary outcome was gender dysphoria as measured by the Gender Preoccupation and Stability Questionnaire (GPSQ).Depression was measured using Patient Health Questionnaire-9 (PHQ-9).Suicidality was measured using the Suicidal Ideation Attributes Scale (SIDAS).Serum total testosterone concentration was determined using an immunoassay (Beckman Coulter Unicel DXI 800 analyzer, with coefficient of variation 5.5% at total testosterone concentrations of 645.5 ng/dL and 11.4% at 89.3 ng/dL [to convert to nanomoles per liter, multiply by 0.0347]; interassay coefficient of variation 7.8%; Beckman Coulter Inc).