Eligibility criteria {10}
burns, fracture, brain injury
RENAL DISEASE
A patient must meet all of the following inclusion criteria to be eligible for inclusion:Skeletally mature (age > 18 years old)Possess an open tibial shaft fracture meeting the following criteria:OTA type 42Primarily closable woundGustilo-Anderson classes I, II, and IIIAA potential patient that meets any of the following criteria will be excluded from participation in the study:Time from injury to presentation at the Muhimbili Orthopaedic Institute greater than 48 hTime from injury to surgery greater than 7 daysAminoglycoside allergyGustilo-Anderson class IIIB or IIICBilateral open tibial fracturesSevere brain injury (GCS < 12)Spinal cord injurySevere vascular injurySevere burns (with greater than 10% total body surface injury or greater than 5% of total body surface area with full thickness or circumferential injury)Pathologic fractureHistory of ipsilateral, active limb infectionEnd-stage renal disease on hemodialysisPatient is unlikely to complete the full year of follow-upIf the patient meets all the inclusion criteria and does not meet any exclusion criteria, the patient will be considered eligible for the study.