Ethics approval and consent to participate
Both studies had been approved by the local Ethics Committee of the Medical Faculty of the Georg-August University Göttingen with the number 6/8/11 and the studies were registered retrospectively on 14/02/2022 on the German Clinical Trials registry (DRKS) with the number DRKS00028079.Informed consent was obtained from all subjects.All experiments were performed in accordance with relevant guidelines and regulations.