Statistical analysis
Based on 3 + 3 design of the study, all patients in this study were included in statistical analysis (n = 12). In this study, quantitative data were presented as mean ± standard deviation or median with interquartile range and qualitative data were expressed as frequency and percentage. Kaplan-Meier curves were used to demonstrate OS and PFS with 95% confidence interval (CI) for the total study population, as well as based on MGMT methylation. To compare continuous variables between different time points and baseline, Wilcoxon signed-rank test was used. P < 0.05 were considered statistically significant. All statistical analyses in the present study were performed using “R” version 3.6.3.