2.3. Surgical Treatment and Antibiotic Therapy Protocols
allergy, PJI, periprosthetic infection
ALLERGY
Surgical treatment of PJI in patients of both groups was performed in one stage, with implantation of a cemented endoprosthesis.In the CG, antibiotic (vancomycin) was mixed with bone cement, without vacuum, during implantation of each endoprosthesis component, followed by etiotropic intravenous systemic antibacterial therapy (daptomycin, vancomycin, cefazolin, ciprofloxacin), which was individual for each patient and based on the organism and allergy profile, antibiogram and renal function, according to clinical guidelines for the treatment of periprosthetic infection [In the hospital, antibiotic therapy in the CG was prescribed based on the sensitivity of microorganisms to drugs according to the following regimens:Cefazolin at a dose of 2.0 g, three times a day for up to two weeks;Vancomycin at a dose of 1.0 g, twice a day for up to four weeks + daptomycin at a dose of 0.5 g, once a day for up to 3 weeks;Ciprofloxacin at a dose of 0.4 g, twice a day for up to four weeks;Cefazolin at a dose of 2.0 g, three times a day + daptomycin at a dose of 0.5 g, once a day for up to two weeks;Vancomycin at a dose of 1.0 g, twice a day for up to one week + cefazolin at a dose of 2.0 g, three times a day for up to three weeks;Vancomycin at a dose of 1.0 g, twice a day + rifampicin at a dose of 0.6 g, once a day for up to two weeks.After discharge, patients in this group were prescribed with oral antibiotics administration: ciprofloxacin, at a dose of 0.5 g, twice a day for three to five weeks; or rifampicin, at a dose of 0.3 g, once a day for three months.