Statistical analysis
REGRESSION
Results are presented as means ± SD. Statistical significance was defined as a probability value < 0.05, and all stated probability values were two-sided. The chi-square test was used to compare categorical variables and an unpaired Student’s t-test was used to compare the mean values of continuous variables between the groups. A paired Student’s t-test was used to assess the differences in the mean values of continuous variables between baseline and 24 months. A linear regression model was used to estimate the changes in FMD over time by treatment (control vs. ipragliflozin group). To estimate the group differences in the percentage changes in FMD, the models included treatment, age, sex, and baseline FMD. Data were processed using R 4.0.1 (R Foundation for Statistical Computing, Vienna, Austria).