Stage IVC patients
METASTASES
In patients with distant metastases (stage IVC) neither surgery nor chemotherapy had a significant effect on OS, but again the higher radiation dose retained its prognostic significance in the univariate analysis (HR = 0.3, 95% CI: 0.1–0.9) when adjusted for age, sex and Karnofsky performance score and in the model with all therapy options (HR = 0.04, 95% CI: 0.002–0.7) (Table Survival analysis comparing therapy modalities in patients with metastases at time of diagnosis using cox proportional hazard modelsBold values identify significant results with Modell 1: Multivariate analysis with age and sexModell 2: Multivariate analysis with age, sex and Karnofsky scaleModell 3: Multivariate analysis with surgery, chemotherapy, radiation dose, age, sex, Karnofsky scale*HR = Hazard ratio, CI = Confidence Interval