4.2.2. Power Calculations
weight reduction
The study was powered to show a 30% improvement (i.e., lowering) of hs-CRP in the treatment group post-intervention. These estimations were based on previous data generated by our research group in the same study population (unpublished consecutive data of an in-house weight reduction program); a standard deviation of 0.61 for log-level hs-CRP was expected. After accounting for a maximum dropout rate of 20% and the power to detect statistical significance at the level of 5%, we estimated that we could include 90 subjects, i.e., 45 participants in each arm.