Aim 1: target engagement (analyzed as single-group)
SESSION
Across doses, we will test whether decreases in within-DMN (mPFC-PCC) functional connectivity occur (during MRI Session 2) from pre- to post-mbNF. MPFC-PCC functional connectivity estimates for each rsfMRI run (including pre-mbNF runs) will be treated as the outcome variable in linear mixed-effects models, with time (0 = pre-mbNF, 1 = post-mbNF) as the focal predictor, such that there will be 4 observations (2 pre-mbNF and 2 post-mbNF runs) for each participant with complete data: