Experimental intervention
obesity, weight loss, LMS, ’
OBESITY
Physical therapists were trained to provide the model of stratified exercise therapy and make:subgroup allocation into the HMS, LMS, or OS groups through a simple stratification algorithm with only two variables (body mass index [BMI] and upper leg muscle strength [30-seconds chair stand test]) (see Supplementary material – Fig. 1 and previous studiessubgroup-specific, protocolized exercise therapy interventions (see Baseline characteristics in OCTOPUS-trial.control arm was not aware and did not use stratification algorithm for subgroup allocation.Dieticians were instructed to deliver a dietary intervention aiming at 10% weight loss in 12 months, according to their clinical guideline to patients in the ‘obesity subgroup’ (see Supplementary material – 