Production and preclinical rationale
death
LIVER METASTASES
Clinical-grade VSV-hIFNb-TYRP1 was produced by the Mayo Clinic Viral Vector Production Laboratory (VVPL) (A prior study (NCT01628640) of VSV-IFNβ (lacking the TYRP1 antigen gene) resulted in a patient death after IT injection, which is thought due to extensive liver metastases (