Introduction
Cancer, breast cancer, malignancy, Breast cancer, lung cancer, HER2-positive metastatic breast cancer, malignant disease
BREAST CANCER, BRAIN METASTASES, BREAST CANCER, COMPLICATION, MALIGNANT DISEASE, LUNG CANCER, METASTASES, CANCER
Breast cancer (BC) has surpassed lung cancer as the most commonly diagnosed malignancy in women according to Global Cancer statistics 2020 [Brain metastases (BrM) is a common complication of advanced malignant disease and occurs in 1/3 of HER2-positive metastatic breast cancer [Studies have confirmed the activity of continued trastuzumab treatment beyond progression (TBP). The subgroup analysis of observational HERMINE study suggested that trastuzumab TBP offered a survival benefit to MBC patients treated with first-line trastuzumab [Dual HER2 blockade by trastuzumab plus TKI, simultaneously targeting the extra- and intra-cellular domains of HER2, showed encouraging anti-tumor activity in BC, including early breast cancer and MBC with intracranial metastases [