Estimation of responder definition thresholds
Total•, neuropathic impairment, Muscle Weakness, neuropathy
REGRESSION, DISEASE, NEUROPATHY, ATTRV-PN
Because ATTRv-PN is a progressive disease with a treatment goal of slowing or stabilizing neuropathy, rather than reversing it, as in previous studies estimating or applying RD thresholds for measures of neuropathic impairment in these patients [Summary of methods used to estimate responder definition (RD) thresholds➣ Mean Change
➣ Linear Regression
➣ Receiver Operating Characteristic Curve

• NIS Total• NIS Sensation• NIS-LL Sensation
• NIS-LL Total• NIS-LL Muscle Weakness➣ Effect Size
➣ Standard Error of Measurement
➣ Standardized Response Mean

