Conclusions
HIV infections
HIV INFECTIONS
Advances in biomedical strategies for HIV prevention continue to emerge. Efforts to diversify HIV prevention options will strengthen our ability to reduce new HIV infections among SGM, whether some SGM desire systemic modalities (e.g., daily oral PrEP; PrEP injectables) or prefer topical protection (e.g., RMs). Regardless of the mode of administration, the effectiveness of these HIV prevention strategies will require that users have access to safe and acceptable products which are easy to use consistently. Our trial addresses the limited data available regarding the safety and acceptability of and adherence to enemas, inserts, and suppositories as potential modalities through which to deliver a rectal microbicide. findings from this trial demonstrate high safety profiles, alongside high levels of acceptability and adherence, among all three modalities. future research examining the acceptability, adherence, safety, and efficacy of promising prep candidates using these three rectal microbicide modalities is encouraged.