Functional neuroimaging data
CORTEX
In the full factorial analysis on whole brain level, the Overview of the peak Abbreviations: L, left; R, right.Whole brain FWE corrected at cluster levelsmall volume FWE corrected at cluster level.Across both drug conditions, (a) Axial slices with corresponding Regarding the drug administration, no overall main effect of OXT was found on whole brain level and in any of the ROIs. We did, however, find a significant interaction of drug × condition in the superior prefrontal cortex (sPFC), although only one voxel exceeded the whole brain FWE correction (−22, 56, 6; To investigate the effect of individual differences of having experienced childhood emotional neglect, we added the CTQ‐EN scores as a covariate in separate repeated measures ANOVAs with the extracted values of a priori ROIs that were found to be significant in the emotion specific Subsequently, to test for the direction of these effects, the CTQ‐EN was added in a correlational analysis with the extracted values of the a priori ROIs amygdala, hippocampus, vmPFC, ACC, and sPFC. We found significant negative correlations between childhood emotional neglect and activation in the amygdala after placebo in all three conditions (positive conditions: Scatterplots of the correlations between extracted parameter estimates from the anatomical bilateral amygdala toward positive (a) and neutral (b) stimuli and the participant scores of the CTQ‐EN, for oxytocin (OXT) and placebo. Scatterplot of the correlation between extracted parameter estimates from the anatomical bilateral hippocampus toward positive stimuli (c) and the participant scores of the CTQ‐EN, for OXT and placebo. Accompanying statistics are described in the text.At the same time, negative correlations between childhood emotional neglect and activation in prefrontal ROIs were found in the OXT condition, which did not hold for placebo (Figure Scatterplot of the correlation between extracted parameter estimates of a 10‐mm sphere around the MNI coordinates 0, 52, −12 (Bzdok et al., No significant correlation was found between CTQ‐EN and ACC, or CTQ‐EN and putamen (all 