Statistical analysis
We planned to recruit at least a total of 48 patients in order to detect the difference in mean BMD of 0.091 g/cmThe study was conducted with approval from the Institutional Research Ethics Committee at the Faculty of Medicine, Chiang Mai University (Ref. number 045/2018). This study was registered with the Thai Clinical Trial Registry, number TCTR20180219004. This study was supported by research grants from the Faculty of Medicine, Chiang Mai University (Grant number 026/2562), and the Thai Society of Hematology.