Introduction
The true efficacy of any treatments under question is something of great importance, definitely. However, it is not only the efficacy of the intervention but rather also the resulting Quality of Life (QoL) that matters. The higher related QoL levels mean that the procedure will meet the patients’ acceptance and the healing will be promoted. Patient-Reported Outcome Measures (PROMs) are real authentic manifestations of the QoL concept, representing the resulting interaction between the patients and the techniques or materials used.Orthodontic treatment of adult patients is frequently challenging because of their higher expectations regarding aesthetics and comfort. Moreover, fast completion of the orthodontic treatment is one of priorities of adults [Although injectable platelet-rich fibrin (i-PRF) is considered to be a promising biomaterial [