Primary outcome
Cancer
ADVERSE EVENTS, ADVERSE EVENT, ADVERSE EVENT, CANCER
Safety was measured by the documentation of local and systemic adverse events. A combination of vital signs, physical examination, and blood test (including the routine manual complete blood count, biochemistry, liver, kidney function, electrolytes, coagulation, cellular immunity, lymphocyte function and cytokines) and urine laboratory tests were used at 1, 4, 8, 12, and 48 weeks. Adverse events were categorized using the National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0 scale (NCI-CTCAE 4.0).