Conflict of interest
Ruifang Liang and Suna Yang are employees of Eddingpharm Co., Ltd., China, which funded this study. Takeshi Kano and Huiyan Pan are employees of Shionogi & Co., Ltd., Japan. The remaining authors (i.e., Zhenbin Ding, Hong Wu, Yongyi Zeng, Ming Kuang, Wei Yang, Zhiqiang Meng, Yajin Chen, Chunyi Hao, Shubing Zou, Huichuan Sun, Chang Liu, Kecan Lin, Guoming Shi, Xiaoying Wang, Xiutao Fu, Rongxin Chen, Yi Chen, Jia Fan, Jian Zhou) disclose no conflicts.