Statistical analysis
anaemia, splenomegaly, hepatomegaly, parasitaemia
ANAEMIA, REGRESSION
The analysis population included all patients who received at least one dose of study drug and had at least one posttreatment Hb measurement. As per the WHO, anaemia of any degree was defined as a Hb < 11 g/dL in children < 5 years and < 11.5 mg/dL in those aged 5–11 years [Multivariable linear regression models assessed a range of clinically relevant variables that, collectively, have been assessed in previous studies [The factors associated with Hb recovery, defined as a D42 Hb > D0 Hb, were determined by logistic regression (age, sex, length of illness, MUAC, D0 Hb, D0 parasitaemia, splenomegaly, hepatomegaly, G6PD, HbS and α-thalassaemia genotype, ACT, SDLPQ/placebo, Hb fractional fall and late treatment failure). In these models, the odds ratios and the corresponding 95% confidence intervals for odds ratios are reported.The times to Hb recovery by G6PD status were determined by the Kaplan–Meier survival approach, and potential explanatory variables for times to Hb recovery were explored by the Cox proportional hazards regression model. In these models, we used the scaled Schoenfeld residuals to test the proportional hazards assumption. Variables not meeting the proportional hazards assumptions were excluded from the analysis. The hazards ratios and the corresponding 95% confidence intervals for hazard ratios are reported. A subgroup analysis (