Author Contributions
INF is the guarantor of integrity of the entire study. INF, SJB, MC, RKA, AMB, AS, PC and DWR were responsible for study concepts and design. INF, JHS, MC, RKA, AMB, AS, PC and DWR were responsible for the clinical studies. INF, SL, SJB and IA carried out the experimental studies/data analysis. IA carried out the statistical analysis. INF, SL, SJB and IA prepared the manuscript. INF, SL, SJB, IA, JHS, MC, RKA, AMB, AS, PC and DWR edited the manuscript.