Introduction
CM, psoriasis
MINOR, DISEASE, PSORIASIS
At present, there is controversy regarding whether the risk of CM in patients with psoriasis is higher than that in the general population (Traditional observational epidemiological studies face many challenges in discovering disease etiology and inferring causality, such as reverse causal associations, potential confounding factors, minor exposure factors, and multiple tests. In observational and retrospective cohort studies, it is difficult to explore a causal relationship between psoriasis and CM with the existence of treatment or other interfering factors beyond our control. Prospective randomized controlled trials or other research methods that can rule out these interfering factors are urgently needed to establish a causal relationship between psoriasis and CM.In recent years, with the continuous development of statistical methods, large-sample genome-wide association study (GWAS) data, epigenetics, and various “omics” techniques, the Mendelian randomization (MR) study design has been increasingly widely used in the discussion of the causal association between complex exposure factors and disease outcomes (