Statistics
All measurements were taken from distinct samples. We used non-parametric rank tests because we could not assume normality, and chose the Wilcoxon paired signed-rank test over Mann–Whitney U test whenever possible to preserve statistical power. A two-sided alpha significance level of 0.05 was used in all tests with Bonferroni correction for multiple hypotheses when required. There was one exception where we used FDR correction for multiple hypotheses and it was clearly stated. Tests statistics can be found in Supplementary Data 