Discussion
bone defects, bone loss
PROLIFERATION, BLOOD, BONE LOSS
Blood consists of liquid, plasma, and cellular components, including white blood cells, red blood cells, and platelets. Platelets play an important role in hemostasis and contain growth factors involved in angiogenesis and tissue healing. Growth factors are associated with cell migration, proliferation, differentiation, and angiogenesis, and promote the tissue regeneration process [Several studies have reported the effects of PRF and CGF on bone regeneration. Kim et al. [Various clinical studies have been conducted on bone regeneration using PRF and CGF. In implant surgery, PRF and CGF provide stabilization of the bone graft in the defect area and minimize bone loss during healing [Unlike in other fields, reports on the effects of PRF and CGF in endodontic microsurgery are scarce. Studies evaluating the clinical effect of PRF alone on bone regeneration after periapical cyst enucleation reported that PRF promotes faster bone regeneration within three months after surgery, and complete bone regeneration and bone density are observed six months after surgery [Several studies on healing after endodontic microsurgery has used traditional two-dimensional periapical radiographs [In this study, new bone formation after three months was more in the experimental groups than that in the control group, demonstrating that PRF and CGF promote bone regeneration. However, no statistically significant difference was observed between the PRF and CGF groups. These results demonstrate that platelet-derived materials are effective for stimulating new bone formation. In the evaluation of bone defects after six months, no significant differences were observed between the three groups. Kim et al. [Attempts to use PRF with bone grafts (sticky bones) have also been reported [This study had some limitations. First, the number of participants was relatively small. Second, the age or sex of the patients was not taken into consideration. These factors may affect the action of growth factors or healing status. Third, the sizes of the bone defects were limited. Fourth, only the effects over a relatively short period of six months were evaluated. Thus, future studies are required in patients with larger and similar-sized lesions with long periods of follow-up.