Aberrant activation of the JAK-STAT pathway in NKTL
NKTL
As the JAK-STAT pathway was found to be implicated in resistance to chidamide, we examined the activity of its effector molecules, STAT3 and STAT5 in both sensitive and resistant NKTL cell lines. High levels of phospho-STAT3 and STAT5 were detected in resistant cell lines compared to sensitive cell lines (Fig. The JAK-STAT pathway is constitutively activated in chidamide-resistant NKTL. 