Outcomes
All patients were followed up until 28 days of enrollment, with time to vasopressor discontinuation as the primary outcome, defined as discontinuation of all vasopressors for at least 48 consecutive hours.Secondary outcomes included vasopressor-free days at 28 days, all-cause mortality at 28 days, serum lactate levels, days on mechanical ventilator, length of stay in ICU and hospital; and the change in serum creatinine, bilirubin, aspartate/alanine aminotransferase, PaO