Conclusions
ovarian cancer, CIPN
OVARIAN CANCER, ADVERSE EFFECT
In the WALC trial, a 6-month aerobic exercise intervention significantly improved self-reported CIPN among patients who had been treated with chemotherapy for ovarian cancer compared with the attention control group. The study provides evidence of the potential benefit of exercise in attenuating a common chemotherapy adverse effect for which there is no accepted treatment. Incorporating referrals to exercise programs into the standard oncology care for patients with ovarian cancer could attenuate CIPN symptoms and increase quality of life. Exercise could also prolong survival by improving chemotherapy adherence, if future studies show the effects of exercise on preventing CIPN during chemotherapy for patients with ovarian cancer.