Secondary analyses
fatigue
REGRESSION, SECONDARY
The analysis was repeated for the secondary outcomes with the T20 measure of the outcome as covariate.The proportion of clinically significantly improved patients assessed with the CIS fatigue subscale in both conditions was also compared with a logistic regression analysis with clinically significantly improved as dichotomous dependent variable, and booster condition and clinically relevant improved (T20) as fixed covariates. Clinically significant improvement was defined as either a score of less than 35 on the CIS20r fatigue severity subscale or an improvement of at least 8 points on this subscale compared with baseline (T0).Analyses were based on the intention-to-treat sample. In case of a large attrition rate (>10%) the analyses were to be repeated on the per protocol sample as well, including participants adherent to the booster allocation.