Methods for additional analyses (e.g. subgroup analyses)
cognitive sequelae
Analyses will be conducted to identify trajectories of participants according to their baseline characteristics (i.e., subgroup identified with the cluster analysis) and the allocated intervention. To explore the effects of the intervention on the two primary outcome measures according to the baseline participant characteristics (profile corresponding to cognitive or psychological difficulties), the same analysis will be performed as for primary outcomes (linear mixed models, see (Analyses will be conducted to identify individual trajectories, in the different cognitive domains and for primary outcome, to identify which variable predict long-term cognitive sequelae. Our analyses will include latent growth curve modelling techniques that use repeated measures to estimate trajectories.