Strengths and limitations
bone metastatic disease
METASTASES
The current study has several strengths and limitations worthy of comment. It is one of the largest RCT’s evaluating the effects of exercise in patients with bone metastatic disease. The approach to exercise prescription in this study was patient inclusive, such that all patients can be prescribed some amount of exercise despite the presence of metastases. This method has significant potential for use in the clinical setting and adds to the recent paradigm shift in relation to exercise prescription in advanced prostate cancer [There are limitations to this study which warrant discussion. Current evidence suggests that resistance training is associated with clinically important positive effects on muscular function and body composition in patients during treatment or in long-term follow-up [