Discussion
gouty, OA, arthritis, pain
DISORDER, ARTHRITIS
In this study, topical solution of Frankincense extract could decrease pain severity and stiffness of knee and improve the patients’ daily activity.To the best of our knowledge, this is the first work evaluating Boswellia extract as a topical form in OA patients. Previously, several animal and human studies have shown the beneficial effects of Boswellia in arthritis.An animal study demonstrated that boswellic acid could significantly suppress the increased level of lysosomal β-glucuronidase and lactate dehydrogenase enzyme releasing from neutrophils and also decreased TNF-α level in gouty arthritic mice [Several clinical trials showed the effectiveness of The biological effects of Boswellia are mainly related to boswellic acids, of which AKBA is the most important one. This compound demonstrates anti-inflammatory and anticancer effects by selective and non-competitive inhibition of 5-lipoxygenase in the pathway of leukotriene biosynthesis [Since topical agents have a role in the management of mild OA due to lower systemic side effects, topical frankincense could be an additional therapeutic option for this disorder as its tolerability seems to be better than topical NSAIDs and capsaicin.