2. Materials and Methods
SCLERODERMA
This is a before-and-after study (non-randomized trial) conducted at the Functional Recovery and Rehabilitation Unit of the A.O.U.P. Paolo Giaccone in Palermo, in collaboration with the Rheumatology Unit of the same hospital. Patients with scleroderma presenting IDU were consecutively enrolled (from April 2022 to November 2022).All aspects of the study were reviewed and approved by the local “Palermo 1” ethics committee, with reference number 6/2020. The ethical guidelines of the Declaration of Helsinki were followed for the study, and the information was handled following the guidelines of the Good Clinical Practice (GCP). The study was registered with ClinicalTrials.gov (NCT05907200).