Multivariable Associations Within Time Points
We constructed 3 multivariable models (one each for baseline, day 2, and day 4) using least absolute shrinkage and selection operator (LASSO).Twenty-eight biomarkers were initially included in our assessment. To develop a sparser model, we used postselection inference to fit reduced models for each time point that included only the 5 that were selected most often by LASSO in each model.