Discussion
PRS
COURSE OF ILLNESS
In addition to the science, we will create rich data and sample resources for the pursuit of related research questions. Our analytic aims are dense, but results will inform follow-on research questions such as: 1) How do genetic and environmental exposures act and co-act to influence risk for ARFID? 2) If detected, how will carriers of CNVs differ on PRS and environmental exposures? 3) Can we identify genetic factors that influence course of illness (e.g., predict who is at risk for developing persistent vs. transient ARFID)? 4) Can we answer precision-medicine questions regarding identification of optimal interventions informed by genotype and environmental exposures? Given the paucity of effective interventions for ARFID (and other EDs) [