Clinical, Functional, Quality of Life, and Global Outcomes at 12 Months
stroke, depression, Stroke
MYOCARDIAL INFARCTION, STROKE, STROKE, EVENT, REGRESSION
Abbreviations: aHR, adjusted hazard ratio; aMD, adjusted mean difference; aOR, adjusted odds ratio; HSUV, health status utility value; ISMN, isosorbide mononitrate; MLR, multiple linear regression; mRS, modified Rankin Scale; MWD, Mann-Whitney difference; NA, not applicable; NIHSS, National Institutes of Health Stroke Scale; OLR, ordinal logistic regression; VAS, visual analog scale.Analyses were performed using binary logistic regression, OLR, or MLR with adjustment for age, sex, time from stroke onset to randomization, years of education, smoking status, and baseline mRS score (dependence), stroke severity (NIHSS), and systolic blood pressure. For ordinal scales with more than 7 levels (central limit theorem/large sample), the mean (SD) and MLR were used instead of the median (IQR) and OLR. Composite includes only patients with complete data for the required outcomes; sensitivity includes all patients, including those with missing data.The MWD is calculated as the probability of having a good outcome on control minus the probability of having a good outcome on treatment. If the probability of having a good outcome on treatment is higher than the control probability, then the result will be below 0.Cox proportional hazard time to event (aHR).Binary logistic regression (aOR).Multiple linear regression (aMD).Ordinal logistic regression (aOR).Includes recurrent ordinal stroke, ordinal myocardial infarction, 7-level cognition, ordinal dependence (mRS score), quality of life using the full Health Status Utility Score of the EuroQol-5D, the Zung full-scale depression score, and binary status of alive or dead. Analyzed using the Wei-Lachin test, not adjusted.Wei-Lachin test (MWD).