Author contributions
SSI, OME
SSI and NIR were responsible for conceptualization, supervision, and data interpretation. NAN and HEl-K performed the clinical and histological examination and collected and tabulated the data. AME formulated, prepared, and tested the oral adhesive gel and patch for treatment drugs and dispensing them to patients. OME was responsible for analysis, interpretation of data, and writing and editing the manuscript. All authors read and approved the final manuscript.