Ethical approval
This study and its protocols were reviewed and approved by the Institutional Review Boards of the University of North Carolina at Chapel Hill, USA (#19–3481), the Guangdong Provincial Dermatology Hospital, China (#2020031), and the Guangzhou Eighth People’s Hospital, China (#202022155). During the eligibility screening, all participants provided verbal consent for screening to the researcher (CL) during the virtual enrollment visit via WeChat. Eligible participants were then proceeded to the formal informed consent process where they were instructed to read a digital consent form, given the opportunity to ask questions before finally electronically signing the informed consent through a digital survey platform. All signed consent forms were then downloaded to a password-protected local drive and stored separately from participants’ survey and clinical visit data.