Exploratory end points
depression, Depressive, Anxiety, anxiety
DISORDER
Exploratory end points included change in total score from Baseline to Week 3 in participant EQ-5D-3 level (EQ-5D-3L) which captures an index of health state based on response to five dimensions of quality of life on a three-point scale ranging from “no problems” to “extreme problems” and additionally includes the EQ-VAS ranging from “worst imaginable health state” (score = 0) to “best imaginable health state” (score =100), Generalized Anxiety Disorder 7-item (GAD-7) where total scores range from 0-21 with higher scores indicating greater severity of anxiety, self-reported Quick Inventory of Depressive Symptomatology 16-item (QIDS-SR-16) where total scores range from 0-27 and higher scores indicate greater severity of depression, the Clinical Global Impression-Improvement (CGI-I) which is a 7-point rating scale of improvement based on clinical judgment, with lower scores indicating greater improvement [The acute subjective psychedelic experience was captured by the Five-Dimensional Altered States of Consciousness questionnaire (5D-ASC) once the acute psychedelic effects had subsided (end of Day 1) [