Supplementary Materials
PVHI
REGRESSION, PERINATAL ARTERIAL ISCHEMIC STROKE, HAEMORRHAGIC INFARCTION, APPENDIX
Appendix 1: CONSORT checklist. Appendix 2: figures of individual developmental trajectories regarding time to self-initiated goal-directed movements in both intervention groups.Click here for additional data file.Early Intensive-Upper Limb (EI-UL) intervention. Stimulating active, self-initiated goal-directed upper limb movement by variable practice with increasing task difficulty aimed to improve performance through repeated motor activity and related sensory feedback (based on Corbetta & Snapp-Childs, [MuSSAP training. In the MuSSAP training, the infant wears a multisensory stimulating wristband (with simultaneous rhythmic visual (led lights), auditory (song), and tactile (vibration) stimuli) to increase attention for the contralesional upper limb. The multisensory wristband worn by the infants in the study is presented in the photo on the right side.Participant flow chart.HAI affected hand scores, BSID-III GM raw scores and GMFM-88 total scores for the intervention groups and typically developing infants on T0, T1, and T2 on the (a) Linear regression lines Participant demographic and baseline (T0) characteristics.Corrected age was calculated for infants born <37 weeks. Abbreviations: EI-UL: Early Intensive-Upper Limb intervention; MuSSAP: Multi Sensory Stimulation And Priming; MRI: Magnetic Resonance Imaging; PAIS: perinatal arterial ischemic stroke; PVHI: periventricular haemorrhagic infarction; HAI: Hand Assessment for Infants; BSID-III-NL: Bayley Scales of Infant and Toddler Development-Third Edition-Dutch version; GMFM: Gross Motor Function Measure-88; ITQOL; Infant and Toddler Quality Of Life questionnaire Short Form 47. HAI scores before intervention (T0), after intervention (T1), and eight weeks after the intervention stopped (T2).
Quality of life (mean and range) measured in both intervention groups and in typically developing infants at T0, T1, and T2.
