Adverse events
ADVERSE EVENT, MINOR, SKIN DISORDERS, HEART ATTACK
Only one Serious Adverse Event (SAE) (a heart attack) was reported during the study, but it was unrelated to the FCH. Only a few minor Adverse Events (AE) (i.e., gastro-intestinal, urinary, or skin disorders, see Table 
Distribution of the link of AE and SAE with FCH– Safety population – N = 28 adverse eventsTaken together, our data suggest an improvement of the articular function. In order to further demonstrate the biological activity of FCH on cartilage tissue and provide clues on the mechanisms likely contributing to its benefits for human articular function, we investigated the influence of human circulating metabolites following FCH ingestion on primary human articular chondrocytes behavior 