4. Discussion
IBS, diabetes type 2 [, inflammation
INFLAMMATION, MINOR
This is the first clinical trial to study changes in the gut microbiota composition, SCFAs, and the metabolome when provoking subjects with IBS with high doses of FODMAPs and gluten. FODMAPs, but not gluten, altered the gut microbiota composition, in particular causing an increased proportion of saccharolytic genera, corresponding to an increased exposure to fermentable carbohydrates. There were also minor effects of FODMAPs and gluten on SCFAs. FODMAP-related genera correlated with phenolic-derived metabolites and IPA. These metabolites have previously been associated with improved metabolic health and reduced risk of inflammation and diabetes type 2 [