Intervention
stroke
STROKE
A trained nutritionist (K.B.) under the supervision of an expert neurologist (F.KH.) implemented the study. Sixty-six patients with stroke were divided into two groups: (i) the intervention group (n = 33) received a tablet containing 505 mg/day curcumin-piperine with 95% purity, (each tablet provided 500 mg curcumin and 5 mg piperine purely) for 12 weeks, and (ii) patients in the control group received a placebo tablet matched with the intervention in terms of size, shape, and color (n = 33) for the same duration. Patients were asked to take tablets one hour after eating breakfast. Any remaining supplements were counted at the end of the intervention. If more than 10% of the supplement was not taken by participants during the study, they were excluded from the study. Compliance was determined from the capsule count in the bottles at the end of the trial, and patients should at least consume 90% of tablets within the study [Intervention with 505 mg curcumin-piperine for 12 weeks was used because this study was the first to assess the efficacy of curcumin-piperine in patients with stroke, and the same dose has been the most frequently used dose with documented efficacy and safety in previous trials. Although curcumin is safe at higher doses [