Findings
ILI
SECONDARY, DISEASE, INFLUENZA, INFLUENZA-LIKE ILLNESS
In this secondary analysis of the INVESTED randomized clinical trial of 3094 participants from US sites with available weekly Centers for Disease Control and Prevention–reported influenza-like illness (ILI) activity, ILI was temporally associated with cardiopulmonary and cardiovascular (CV) hospitalizations. However, high-dose compared with standard-dose influenza vaccine did not significantly reduce occurrence of the primary outcome.