Conclusions
inadequate bowel
Step 1 (1.5 times the standard-dose of PEG) and Step 2 (2.0 times the standard-dose of PEG) preparations from our multi-step escalating high-dose extended cleansing protocol using PEG and Gatorade were highly efficacious, safe, well tolerated and well accepted by subjects whose previous colon preparations were inadequate.
This is the first prospective study looking at high-dose bowel preparation solutions for patients who previously had an inadequate bowel preparations for colonoscopy. Bowel preparation solutions have been sold in fixed-dose packages with a "one-size-fit-all" dosing approach for the past 40 years. With this study, we continue to show how the flexible dosing of PEG and Gatorade allows the needs of a diverse patient population to be met. Patients willing to consume a split-dose preparation do well with 306 g of PEG, patients who want a day-prior preparation require 357 g of PEG and we have observed patients with a history of a borderline inadequate preparation doing well with 374 g of PEG given as a spit-dose. Now we report 459 g of PEG given as an extended split-dose preparation works well for those who failed standard dose preparations and 612 g of PEG works well for those who failed 1.5 times the standard preparation.