Randomization and masking
In this trial, eligible patients were randomly assigned (1:1) using a computer-generated randomization sequence with a block size of four and sealed envelopes, prepared by an independent statistician, into either HDP group receiving Trendelenburg as an adjunct to guideline-based medical management, or a control group only receiving guideline-based medical management. The final 90-day mRS was evaluated by one qualified personnel who was blinded to treatment allocation according to a standardized procedure manual in each study center. Central adjudication of clinical and safety outcomes was also conducted by assessors unaware of treatment allocation or clinical details.