Patients
treatment-resistant
MALIGNANCIES, DISEASE
The key eligibility criteria were male and female patients > 18 years old with histologically diagnosed malignancies, advanced and guideline treatment-resistant, with progressive disease. Laboratory and clinical data showing well-preserved organ functions were required, without signs of major general deterioration (ECOG 0–2 was eligible). All patients provided written informed consent.In total, 24 patients were screened, and 19 patients were treated. Of these patients, 17 were found to be evaluable on the primary endpoint. Two patients were excluded from the analysis for limited data collection due to no completion of the scheduled 4 days treatment. Two additional patients were enrolled in the pre-planned expansion cohort. The median follow-up of treated patients was 56 days.