Scenario Analyses
ADVERSE EVENTS, REGRESSION
In scenario analyses, the QoL reductions and additional annual hospital costs associated with adverse events were reestimated by only including the UK study participants in analysis from the UK perspective, and separately, only including the participants recruited in North America in the analysis from the US perspective. Furthermore, results from scenario analysis excluding the adjustment for participant baseline QoL were reported (for use in situations when no baseline QoL is available). In a further scenario analysis, the QoL regression model was estimated only among study participants recruited in China and using the Chinese EQ‐5D tariff.All analyses were conducted using R 3.4.2. The study was approved by Oxfordshire Research Ethics Committee (REC) B (10/H0605/83). All the patients provided written informed consent.