Insights in pathogenic mechanisms in the early development of asthma
wheezing, asthma, wheeze
ASTHMA
With our multi-omics approach we expect to unravel important pathogenic pathways in the early development of asthma and transient wheeze. We will apply genomics, transcriptomics of blood and nasal epithelium, microbiomics, epigenetics, and metabolomics to establish an integral pathogenic mechanisms for the early development of asthma.In the ADEM-study we found an interaction between bacterial colonisation of the upper airways, genetic variants in the Since the ADEM-study, multi-omics techniques extended and improved substantially, which increase the possibility to identify basic pathogenic mechanisms in ADEM2. Once fundamental pathways have been revealed, potential new therapies can be developed and tested, which hopefully can prevent the early development of asthma in wheezing preschool children.