Author contributions
P.R. and M.T. designed the study. P.R., M.T. and M.M.R. led the data analysis. M.M.R. and T.B. analyzed and interpreted the clinical data. C.A.L. and M.S. generated the metabolite data. J.L.G., T.M.S. and E.H. generated the microbiome data. J.L.G., T.M.S., C.A.L., M.S., G.D. and M.M.R. analyzed and interpreted the microbiome and metabolite data. J. Maciejewski, A.P., S.A., M. Ghosh, J. Magenau, D.K., S.C., G.Y. and M. Geer assisted with the clinical procedures. M.M.R. and P.R. wrote the paper. All authors critically revised the draft and approved the final paper.