Introduction
T1D, chronic disorder
CHRONIC DISORDER, DISEASE PROGRESSION, ADVERSE EVENTS, DISEASE, TYPE 1 DIABETES
Type 1 diabetes (T1D) is a chronic disorder requiring lifelong treatment. Despite intensive treatment, the disease causes substantial morbidity and mortality. Several clinical intervention trials with different approaches to delay or halt disease progression have shown limited efficacy, sometimes accompanied with adverse events (Use of 65-kD isoform of glutamic acid decarboxylase (GADHere we describe treatment effect on the immune response of patients who participated in the DIAGNODE-2 trial, comparing the effect in the GAD-alum treated patients in relation to the placebo group, as well as focusing on the immunomodulatory effect of GAD-alum in the patients both according to the presence or absence of the DR3DQ2 haplotype and according to the preservation of beta cell function.