Design
colorectal peritoneal metastases
CAIRO6 is an investigator-initiated, parallel-group, open-label, phase II–III, randomized, superiority trial conducted in all nine Dutch tertiary hospitals for the surgical treatment of colorectal peritoneal metastases. The trial is approved by a central ethics committee (MEC-U, Nieuwegein, the Netherlands, R16.056) and the institutional review boards of all participating hospitals. The trial is registered (Clinicaltrials.gov: NCT02758951). The trial protocol