SRS-2 Total scores at Visit 1 (Baseline) and Visit 3 (Post-treatment).
The solid diagonal line represents ‘line of no change’ and the dotted lines represent upper and lower Reliable Change Index (RCI) confidence limits. Test-retest reliability = 0.84; s.d. for baseline = 25.47.Inspection of the figure shows that, within the younger age group, 94.4% (17/18) of participants fell at or on the improvement size of the ‘line of no change’ (i.e., RCI = 0) after oxytocin and 38.5% (5/13) of participants fell at or on the improvement size of the ‘line of no change’ (i.e., RCI = 0) after placebo. 27.8% (5/18) participants showed clinically significant improvement after oxytocin, while 15.4% (2/13) showed clinically significant improvement after placebo. No participants showed clinically significant deterioration after oxytocin or placebo.Within the older age group, 70.4% (19/27) of participants fell at or on the improvement size of the ‘line of no change’ (i.e., RCI = 0) after oxytocin. 82.8% (24/29) of participants fell at or on the improvement size of the ‘line of no change’ (i.e., RCI = 0) after placebo. A total of 18.5% (5/27) participants showed clinically significant improvement after oxytocin, while 31.0% (9/29) showed clinically significant improvement after placebo. 3.7% (1/27) participants showed clinically significant deterioration after oxytocin, while no participants showed clinically significant deterioration after placebo.