Introduction
VASODILATION, SECONDARY
As the global sports nutrition market totaled $10.7 billion in 2020 with a projected growth of 10.9% from 2021 to 2028 [During exercise, the demand for oxygen delivery and energy substrates is elevated in the working skeletal muscle. These demands are met with an increase in vasodilation and blood flow [Nitric oxide and nitrates have been the focus of most research on vascular function and performance as they have consistently demonstrated the ability to increase blood flow and prolong time to exhaustion (TTE) [While L-citrulline combined with GSH is known to enhance the effectiveness of resistance training, it is unclear whether it improves endurance performance. The purpose of the current study was to investigate the effects of L-citrulline + GSH on aerobic exercise performance and blood flow in well-trained men. The primary aim of this study was to determine the effects of orally delivered L-citrulline + GSH (Setria Performance Blend: SPB) vs. placebo on endurance performance, and blood flow before and after exercise in aerobically fit men. We hypothesized that the SPB would improve aerobic performance, increase blood flow, and increase vessel diameter compared the placebo. The secondary aim was to identify the effects of L-citrulline + GSH supplementation on blood metabolites of L-arginine, and L-citrulline. We hypothesized that the SPB would increase plasma concentrations of L-arginine and L-citrulline compared to the placebo.