Randomisation
Participants are randomised in a 1:1 ratio to receive either trientine or placebo. Randomisation is accomplished over the internet using web randomisation software accessed using a secure website provided by the clinical trials unit. Block randomisation, stratified by site, is implemented, with computer generated randomisation allocations and randomly varying block sizes. The randomisation code has been generated by an independent clinical trials unit statistician who is not involved with TEMPEST.