Introduction
Obesity, weight loss
OBESITY, BRAIN ATROPHY, BRAIN
Brain aging is a complex, multifaceted process with various manifestations in different periods of the human lifespan, brain regions, and imaging modalities (Obesity is associated with multiple adverse health impacts also observed in normal aging (We previously found that weight loss, glycemic control, lowering of blood pressure, and increment in polyphenols-rich food were associated with an attenuation in brain atrophy (Here, as a sub-study of the Dietary Intervention Randomized Controlled Trial Polyphenols Unprocessed Study (DIRECT-PLUS 