Author Contribution
T.T.C., Z.X.L. and X.R.D. designed the study and funded it.，Q.X., L.J.H, X.T. and Y.J.L. carried out the experiments, W.J.C., D.F.L. and J.W. sorted out the experimental data，F.W. and Y.K. finished writing the article. All authors read and approved the manuscript and agree to be accountable for all aspects of the research in order to ensure that the integrity of any part of the study.