Study design
This single-center, prospective, randomized, controlled trial was conducted from November 2021 to July 2022 at Qilu Hospital of Shandong University in Jinan, China. Ethical approval was granted by the Medical Ethics Committee (Chairperson Professor Tian Hui) of Qilu Hospital, Shandong University ((Ke) Lun Audit 2021 (186)) on 15/07/2021. The study was registered on 23/10/2021 (