Statistical analysis
Categorical data were summarized by proportions, while continuous data by median [interquartile range] values. Percent changes in study variables from baseline after 1-week of placebo and after 1-week of reb-oxy were compared as continuous variables by using a two-tailed Wilcoxon matched-pairs signed-rank test. The effect of the drug combination on the cardiovascular autonomic nervous system reported here was a prespecified exploratory outcome, while the primary outcome was AHI change as reported in our previous publicationA 