Intracerebral venous permeabilization is observed after BBB closure
CSF effusions
EFFUSIONS
Complete clearance of contrast tracer was observed at all treated parenchymal brain sites of 8 of 8 persons (100%) within 24 h post sonication (Fig. Venous permeabilization is observed multifocally within the brain following FUS mediated blood–brain barrier opening and persists beyond the time of BBB closure, for up to one week post FUS intervention. Parietal, frontal, and hippocampal FUS target sites are shown on T2-weighted images in three patients Cerebrospinal fluid effusions and susceptibility effects are observed after blood–brain barrier opening. Frontal and parietal FUS target sites are shown on T2-weighted images in three patients Summary of post FUS MRI effects and temporal progression of CSF effusions. Schematic diagram showing MRI enhancement patterns in the acute post-treatment period. This includes a perivenous pattern and subarachnoid space pattern of contrast enhancement 