Study design and participants
extramedullary disease, Relapsed AML
ONCOLOGY, RECURRENCE, REFRACTORY AML, AML
In this multicenter, phase 2 trial, patients were enrolled at ten hospitals in China. Patients with R/R AML (aged 18–65 years) who had an Eastern Cooperative Oncology Group performance status of 0–2 were eligible for this trial. Refractory AML was defined as no CRc and a reduction in bone marrow (BM) blasts of less than 50% after one cycle or no CRc after two cycles. Relapsed AML was defined as recurrence of blasts in the peripheral blood (PB) or BM blasts ≥ 5% or development of extramedullary disease after achieving CRc [