Study design and recruitment
MM, pain
MULTIPLE MYELOMA, RECRUITMENT, MYELOMA
Patients were recruited at the Multiple Myeloma Center of the Department of Internal Medicine II at the University Hospital Würzburg. This is the first interim analysis of a monocentric, non-randomized, observational clinical trial including 70 patients (DRKS00025422). All patients were diagnosed with MM according to current International Myeloma Working Group (IMWG) criteria [The patients were divided into 2 groups: 1. Patients with ongoing treatment with BTZ at time of recruitment (OT), 2. Patients with BTZ treatment in the past (PT).The Ethics Committee of the Medical Faculty of the University of Würzburg approved the study (# 98/20). After oral and written information, discussion, and a reflection period of at least 24 h, patients who agreed to participate signed the consent form and were thus included in the study. Controls for NfL detection in the serum were healthy volunteers without pain or other known neurological conditions (Ethics approval # 242/17).