Contribution statement
MR
MR initiated the study, led the clinical experiments, and wrote, reviewed and edited the manuscript. TS led the clinical experiments, obtained and analysed the data, and wrote, edited and reviewed the manuscript. SK, HK, GB, SD, RG, SGM, PB, LM, CH and MW made significant contributions to data collection or analysis and interpretation of the data. All authors were involved in critically revising the article and have given final approval of the version to be published. MR is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and data analysis.