Correlation analysis of humoral and cell-mediated immune responses elicited by rNV-2v administration
IgA
HEAT
A correlation analysis was performed using the Spearman test on all available data from the low (rNV-2v 50 µg) and high (rNV-2v 150 µg) dose groups for all assays done (the placebo group was not considered here).The analysis revealed a correlation between all IgG titers for the GI and GII vaccines and non-vaccine VLPs. The strongest correlation was detected between reactions against the different VLPs derived from strains of the GII.4 genotype and the weakest between GI and GII VLPs and for GII.6 Maryland (2018) (Correlation between the different humoral and cell-mediated immune responses triggered by rNV-2v. Correlation matrices are provided as heat maps for responses against vaccine strains GI.4 Chiba 407 (1987) When analyzing the humoral (total Ig, IgG, IgA, Pig Gastric Mucin [PGM] blocking assay) and cell-mediated responses (lymphoproliferation assay [LPA], CD4For the vaccine GI.4 VLPs, the data for humoral responses correlated well with cellular immunity parameters, except for IgA (