Trial steering committee and data monitoring committee
TSC
EAGLE constituted a Trial Steering Committee (TSC) and Data Monitoring Committee (DMC) to provide ongoing oversight and independent decision-making in response to challenges. The DMC had access to unblinded, interim data summaries from wholly and partially completed batches of the trial, and their remit included monitoring the assumptions of the original sample size calculation. They also had the power to recommend to the TSC that the entire trial be stopped early, or that a single ongoing batch be terminated. The TSC acted in the usual role of “critical friend” [