Author contributions
AJS and SMM designed the clinical protocol. NM, AK, KVC, IO, FE, PH, MJDCL, MLC, SPL, SB, MC, and MS recruited participants and performed and supervised clinical practices. IN designed and performed the brain MRI analysis. B Kuca supervised the clinical study execution and was responsible for regulatory submissions. EZ, JK, and B Kaufman performed the data analysis. EZ and JK designed the data analysis and wrote the original draft of the manuscript. All authors reviewed and edited the manuscript.