2.1. Study Design
This was a prospective, double-blind study, in which 200 patients who were about to undergo a LC procedure were recruited. The study was approved by the Institutional Review Board (study approval no. 0238-19-ASF) and registered at the My Trial database of the Israeli Ministry of Health (registration number MOH_2019-12-12_008555). All patients signed an informed consent form. The patients were randomized into 4 groups: patients receiving one of the following a TAP block alone, a subcostal Tap block alone, a subcostal TAP block with a TAP block or a subcostal TAP with a rectus sheath block. All those peripheral blocks were injected after the administration of the general anesthesia, before any surgical incision was performed. No sedatives were administered to the patients before the surgery procedure.The anesthesia was performed by a specialist anesthesiologist with over 10 years' experience who had over two years practice in the administration of the tested peripheral blocks.