Outcomes
Stroke, cognitive impairment
EVENTS, RECRUITMENT, STROKE, BRAIN ATROPHY
The primary outcome was feasibility of recruitment and retention (defined as >95% of randomized patients retained at 1 year). Secondary outcomes included safety (primarily deathAt 12 months, central masked staff assessed the following: recurrent vascular events, mRS score, and cognitive impairment, using the telephone Montreal Cognitive Assessment (tMoCA) and the Telephone Interview of Cognitive Status (TICS); mood, using the Zung score; QOL, using the 5-level EuroQol-5D visual analog score; and the Stroke Impact Scale (SIS) to assess multiple domains of participant-reported physical or cognitive function, dependence, and QOL.Site staff obtained brain MRI, blood pressure, and Trail Making Test Part B results at 12 months. Central masked staff assessed MRI for new infarcts, cSVD lesions, and brain atrophy.