Introduction
ColdZyme mouth, upper respiratory viral infection
VIRUS, RESPIRATORY VIRAL INFECTION, COMMON COLDS, COMMON COLD, CAVITY
The common cold is a self-limiting upper respiratory viral infection affecting the individual and also the society in its high costs and lost productivity [Thus, the first opportunity to halt local virus propagation is during the incubation period. There are few approved products designed to intervene early in common upper respiratory viral infections involving the posterior oral-pharyngeal cavity. A technology has been developed consisting of a hyperosmotic glycerol solution containing cold-adapted trypsin from the Atlantic cod to treat and alleviate the common cold [The current study was preceded by a single-blind study conducted in the same type of population (i.e. individuals with frequent common colds) to assess whether the study design could adequately assess the common cold using symptom scoring with the Jackson scale as well as by quality of life scoring with the 9-item Wisconsin Upper Respiratory Symptom Survey (WURSS-21) Quality of Life (QoL) sub-score [Throat sprays are not commonly used or approved to reduce the burden of a common cold. The aim of this present study was to demonstrate that ColdZyme mouth spray is superior to placebo in the treatment of naturally occurring common colds in a placebo-controlled design. The primary objective was to evaluate the impact on quality of life during a common cold episode based on the primary endpoint defined as the AUC of WURSS-21 QoL composite sub-score over 8 days following start of symptoms. Additionally, the safety of ColdZyme was assessed.