Main
cryopyrin-associated autoinflammatory syndromes, autoimmune diseases
AUTOIMMUNE DISEASES, DISEASES
Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs) mediating cellular activation by TLR agonists and IL-1 family cytokinesClinical validation for targeting the TLR/IL-1R pathway in autoimmune diseases has come from the activity of antibodies targeting different IL-1 family cytokines in diseases, such as cryopyrin-associated autoinflammatory syndromes (IL-1) (ref. Targeted protein degradation involves the use of heterobifunctional small molecules to bring an E3 ligase together with a protein of interest to mediate its ubiquitination and degradation by the proteasome