Eligibility criteria
fractures, teeth, pain
ADVERSE REACTIONS, PERIODONTITIS, HAND INFECTION
In this study, Consolidated Standards of Reporting Trials guidelines were followed (Fig. Flow diagram CONSORT for randomized clinical trialsThe sample comprised patients requiring non-surgical retreatment in previously treated mandibular premolar teeth with asymptomaticapical periodontitis.The inclusion criteria were as follows:
Healthy individuals between aged 18 and 50 years.Previously root canal treated mandibular premolar teeth with asymptomatic apical periodontitisconfirmed by clinical and radiolographic examination.Single rooted mandibular premolar teeth with single canal that were confirmed by periapical radiographs.Teeth with previous root canal obturation 2–4 mm short of the apex.Periapical radiolucency (PAI 3–4) detected [Presence of intact coronal restoration.Teeth on which root canal treatment had been performed in the researcher’s hospital at least 4 years before the study.The exclusion criteria were as follows:
Use of drugs, such as analgesics, anti-inflammatories, and antibiotics, for pain and infection control in the previous 12 h.A history of susceptibility or adverse reactions to any drugs or materials used in the study.Teeth with open apexes and resorption.Teeth with post-core restoration.Vertical root fractures and teeth on which surgery had been performed.Pregnancy and breastfeeding.