Anti-teduglutide antibodies
hypersensitivity
HYPERSENSITIVITY, HYPERSENSITIVITY REACTION
At 24 weeks, 5 out of 14 patients (35.7%; Detection of anti-teduglutide antibodies from baseline to the interim data cut-off pointThe patient with the highest titer of anti-teduglutide antibodies (1:650 at month 12) had sustained reductions in PS volume at the time of the interim data cut-off (28.6% reduction in PS volume), and there were no signs of hypersensitivity. Among the 7 patients who tested positive for anti-teduglutide antibodies, 1 (14.3%) did not achieve a reduction in PS volume greater than 20% and discontinued treatment after week 24; this patient had a low titer of anti-teduglutide antibodies (1:20) at week 24. Overall, no association with AEs of hypersensitivity or teduglutide-related hypersensitivity reaction was observed among the patients in whom anti-teduglutide antibodies were detected. Furthermore, no association between anti-teduglutide antibodies and a lack of efficacy was observed.