Mean (standard deviation) of the VL estimated by the Ct value obtained in the PCR reaction as a function of the group and time. Different letters (upper case comparing horizontally between groups and lowercase comparing vertically between times) indicate statistically significant differences. Group 1 (G1): use of mouthwash containing placebo + placebo nasal spray; Group 2 (G2): use of mouthwash containing phthalocyanine + placebo nasal spray; Group 3 (G3): use of mouthwash containing phthalocyanine + nasal spray containing phthalocyanine