Measurements
blood loss, hypotension
BLOOD LOSS, EVENTS
Intraoperative: operative time (measured from time of skin incision to wound suturing); blood loss; blood transfusion volumes and other blood products (platelet concentrate, fresh frozen plasma); intraoperative major events (hypotension for greater than 20 min and use of inotropes); and laparoscopic to open conversion. The conversion is defined as the change of surgical approach during the resection phase of major hepatectomy, when the operating surgeon encounters technical difficulty. Patients undergoing conversion will be included in the laparoscopic group and be analysed on an ‘intention-to-treat’ basis.Postoperative: liver biochemistry and coagulation profile on postoperative days 1, 3, 7, and day of discharge; postoperative morbidities according to Clavien–Dindo classification