Changes to prespecified analyses
SECONDARY
The unblinded SNAP trial analytic team will monitor the primary and secondary model behaviour, including numerical stability and scientific appropriateness. Alternative models may be needed if there are unforeseen numerical, data, or modelling problems. Any alternatives will be implemented by the SNAP trial analytic team and communicated to the data safety and monitoring committee and may be reported to the global trial steering committee providing that there is no risk to trial integrity.