Associations between within-class FA plasma concentrations and CMD risk in EPIC-Potsdam
CMD, T2D, TG
CVD
To contextualize the observed dietary effects, we determined whether all lipids that significantly changed in response to replacing SFA with UFA in the DIVAS study were associated with CMD risk in the EPIC-Potsdam study. HRs for the associations between within-class FA concentrations and incident risks of CVD or T2D were computed using multivariable proportional hazards Cox models, adjusted for age (timescale), sex, waist circumference (data not shown), height, leisure time physical activity, smoking status, alcohol intake, highest achieved education level, fasting status as blood draw, total energy intake, diastolic and SBPs, circulating total cholesterol, HDL cholesterol, and TG concentrations, antihypertensive medication, lipid-lowering medication, and acetylsalicylic acid medication. In addition, each model was adjusted for the concentration of the total lipid class to which the within-class FA concentration of interest belonged (e.g., models on DAG [16:0] were adjusted for total DAG plasma concentration). All within-class FA concentrations were log-transformed and 