Statistical analysis
hyponatremia
HYPONATREMIA, SECONDARY
The sample size calculation is described in detail elsewhereTotal 24 h natriuresis was normally distributed and calculated and presented as mean ± standard deviation. The between-group difference was tested using Student’s We performed prespecified subgroup analyses of both components of the dual primary endpoint on the basis of the following covariates: age (≤/> median), sex, left ventricular ejection fraction (LVEF ≤40% versus >40%), NT-proBNP (≤/> median), eGFR (≤/> median), HF etiology (ischemic/non-ischemic), outpatient dose of loop diuretic use (yes/no)), hyponatremia (sodium ≤135 mmol lAll primary, secondary, safety and exploratory analyses were prespecified in the statistical analysis plan and performed in the intention-to-treat population (Supplementary Note 