Conclusion
In adult Japanese patients with SBS-IF, treatment with teduglutide 0.05 mg/kg SC once daily elicited clinically meaningful reductions in PS requirements. Teduglutide was quickly absorbed and did not accumulate following multiple doses. The effects of teduglutide continued during long-term treatment. No new safety concerns were identified within these short- and long-term studies. These three studies demonstrate that adult Japanese patients with SBS-IF benefit from short- and long-term treatment with teduglutide in a similar manner to patients from North America and Europe. Anti-teduglutide antibody titers, if developed, generally declined to undetectable levels with long-term treatment. These results constitute the longest evaluation of teduglutide treatment within clinical trials reported to date.