Introduction
mesenchymal tumours
RECURRENCE, SOFT TISSUE SARCOMAS, PROLIFERATION, DISEASE, SOFT TISSUE SARCOMA, MALIGNANCIES, SOFT TISSUE SARCOMA
Soft tissue sarcomas are rare mesenchymal tumours that can occur at any site [Angiogenesis is a critical process in the development of many malignancies, including soft tissue sarcomas. Circulating levels of the angiogenic factors vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) are raised in patients with soft tissue sarcoma and correlate to disease extent and risk of recurrence [Axitinib is an oral tyrosine kinase inhibitor targeting VEGFR-1, VEGFR-2, VEGFR-3, platelet-derived growth factor receptor (PDGFR)-β and KIT, blocking autophosphorylation and inhibiting endothelial proliferation and survival [