Study population
tumor, tumors, supratentorial glioblastoma
TUMOR, TUMORS
Inclusion criteria were defined as follows:
Patients aged ≥ 18 with radiologically suspected diagnosis of supratentorial glioblastoma for whom the multidisciplinary tumor board advised biopsy only and/or patient wished no resection.Maximal volume ≤ 70 cc on post-contrast T1 magnetic resonance imaging (MRI).Safe trajectory/trajectories possible for ablation of at least 70% of the tumor, avoiding eloquent structures or transgression of a ventricle or vessel.Karnofsky Performance Score (KPS) ≥ 70.Exclusion criteria included:
Contra-indication for general anesthesia or MRI.Lesion > 70 cc on post-contrast MRI on the day before intervention.Non-glioblastoma diagnosis as per frozen section analysis or final histology.Pregnancy.Multifocality and cystic aspect of the tumor were initially defined as exclusion criteria, but the 70% ablation criterium already ensured that highly multifocal and cystic tumors were excluded from the study. Hence these were removed as separate exclusion criteria.