Authors’ contributions
All authors were involved in the concept and design of the study, discussed statistical analyses, participated in writing the manuscript, and read and approved the final draft before submission. LV performed the statistical analyses. JT, TP, LW and J-BB enrolled patients in the study. JT assumes final responsibility for the work, had access to all data, and controlled the decision to submit this work for publication. The corresponding author attests that all listed authors meet authorship criteria and that no others meeting the criteria have been omitted.