Economic evaluation analyses
RECURRENCE, SENSITIVITY
The economic evaluation will be conducted from the societal perspective as the primary analysis, whilst the Australian health system perspective will be used for sensitivity analyses. The time horizon of the economic analysis is 12 months.For the economic evaluation, missing cost and effect data will be imputed using multivariate imputation by chained equations with predictive mean matching [Incremental cost-effectiveness ratios (ICERs) will be calculated by dividing the between-group difference in costs by the between-group difference in effects (i.e. cost per recurrence prevented, and cost per QALY gained). The uncertainty surrounding ICERs will be estimated using bootstrapping as well (5000 replications) and graphically presented on cost-effectiveness planes. Cost-effectiveness acceptability curves will be estimated to show the probability of the intervention being cost-effective for a range of willingness to pay (i.e. maximum amount decision-makers are willing to pay per unit of effect gained). Sensitivity analyses will be performed to assess the robustness of the results based on a complete-case analysis and an analysis from the Australian health system perspective.