Abbreviations:
anxiety
adverse eventsAshwagandha root extractCambridge Neuropsychological Test Automated BatteryCambridge Gambling TaskCGT mean decision time total mergedCambridge Gambling Task, decision-making quality totalCGT-risk-taking total mergeddelayed matching sampledelayed matching sample percent correct (simultaneous)delayed matching sample total correctestimated glomerular filtration rategeneralized anxiety disordergood clinical practiceglutathionehigh-density lipoprotein-cholesterollow-density lipoprotein-cholesterolmean corpuscular haemoglobin concentrationmalondialdehydemultitasking total incorrectmotor screening taskmotor screening task-mean latencymultitasking testmultitasking total correctnitric oxideperceived stress scalequality of lifevery low-density lipoprotein-cholesterolWorld Health OrganizationWorld Health Organization Quality of Life–BriefSupplemental Digital Content is available for this article.The study was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Committee of Narayana Institute of Cardiac Sciences, Bangalore, and Vijaya Super Specialty Hospital, Nellore for Protocol No. CPL/83/ASH_STRS/I/AUG/19, V3.0,05-FEB-21. The trial was registered prospectively with the Clinical Trial Registry of India (CTRI) with the registration number CTRI/2020/02/023321 on 13/02/2020.Informed consent was obtained from all subjects involved in the study.The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.The authors have no funding to disclose.The trial was registered with the Clinical Trial Registry of India (CTRI) with the registration number CTRI/2020/02/023321 on 13/02/2020.MM, KN, and LM are employees of Sami-Sabinsa group limited or Sabinsa Corporation. All the authors have seen and agreed with the contents of the manuscript.How to cite this article: Majeed M, Nagabhushanam K, Mundkur L. A standardized Ashwagandha root extract alleviates stress, anxiety, and improves quality of life in healthy adults by modulating stress hormones: Results from a randomized, double-blind, placebo-controlled study. Medicine 2023;102:41(e35521).