Participants
malaria
MALARIA
This study was part of the AgeMal project (ClinicalTrials.gov identifier NCT00231452) described previously [The AgeMal study assessed 349 children, as well as their mothers, over a 2-year period. Subsequent data that were collected yearly until 4 years after birth were included in this study. This number had a steady drop-out of participants until the third yearly data collection, at 285 patients, which then remained approximately the same in the final year. The number of primary malarial cases in each recorded year from the first to fourth respectively totalled 58, 111, 111, and 83 cases; however, the primary clinical malaria data for the first year was omitted as interventions were performed during this time.Written informed consent was obtained from all mothers. The study was approved by the National Mozambican Ethics Review Committee (Ref: 05/CNBS/05), the Hospital Clínic of Barcelona Ethics Review Committee, and the Princess Margaret Hospital for Children Ethics Committee (1473/EP) in Perth. All experiments were performed in accordance with relevant guidelines and regulations of the Hospital Clínic of Barcelona and the School of Paediatrics and Child Health, University of Western Australia.