2.6 Ethical approval
The main study was approved by the National Health Science Research Committee of Malawi (Reference 17/05/1821) and the Liverpool School of Tropical Medicine Research Ethics Committee (Reference 17–031). Approval for importation and use of the study investigational products was obtained from the Pharmacy Medicine Poisons Board of Malawi (Reference PMPB/CTRC/2A/CFZ-001). Written informed consent was obtained from the study participants before being enrolled into the trial.