Randomization and blinding
Patients were randomly assigned in a 1:1 ratio to low or high MAP using a web-based system involving dynamic permuted block sizes. The MAP intervention was double-blinded (see intervention). The physicians taking care of trial patients and assessing neurological prognosis were not blinded to bedside JBM and cerebral saturation. The neurophysiologist analyzing the EEGs and evaluating neurologic outcomes was unaware of the trial-group assignments and microdialysis data.