Secondary outcome analysis
SECONDARY
Mixed linear models will also be used to assess the maintenance of effect across time (baseline, immediate and long-term follow-up). We will re-run the same analysis as for primary outcome, this time by including scores at long-term follow-up. Intervention effect size will be estimated using the same mixed models for each secondary and exploratory outcome measurement (Scores of ISQV and EQ-5D, the 5 overall Z-score per cognitive domain, Outcome-Questionnaire 45, PSQI, M-FIS) at both short-term follow-up (T1) and long-term follow-up (T2). As a rule, stratification factors will be included in the analyses.