Statistical analysis
SD
The normality of the data was checked by the Shapiro–Wilk test. The unpaired Student’s t-test for continuous variables was used to compare parameters between groups with normal distributions, the non-parametric Mann-Whitney U test for continuous parameters with skewed distributions, and the χ2 test/Fisher’s exact test for categorical variables. Continuous values were expressed as mean ± SD and categorical values as percentages.Patients who completed follow-up were added to the following analyses. Repeated-measure analyses of variance (ANOVA) was used for continuous variables, to assess the relationship of changes at follow-up between groups. Generalized linear mixed models were used to compare the categorical data. The categorical parameters were entered subsequently as the dependent variable, and group (standard CR vs. OPTICARE XL CR) and follow-up as the independent variables. Random intercepts were used to account for the patient ID.All statistical tests were 2-sided and a p-value of 0.05 was considered statistically significant. The analyses were performed with SPSS version 25 and R version 3.6.0 (glm package).