Statistical methods for primary and secondary outcomes {20a}
®, pain
REGRESSION, SECONDARY, BLEEDS
The difference in percentages between the two groups will be determined by a chi-square test, thus allowing us to meet the main objective. This result will be adjusted according to several criteria, two of them in particular: a center effect, a baseline effect, and an effect of the degree of experience of nurses.Indeed, the analysis of cluster trials is more complex than the analysis of trials with individual randomization units. The analysis will therefore also be carried out at the cluster level using the guide of the French Health Authority of June 2007 (methodological guide downloadable from The secondary objectives (number of per-dialytic bleeds, accidental needle withdrawals) will be analyzed according to the same procedures as for the primary objective. The pain score (numeric scale) at the time of puncture will be analyzed between the two groups by Student’s All the parameters collected will be analyzed.Multivariate analyses will be considered according to the results of univariate analyses such as logistic regression comparing the two groups and mixed models.The adjustments described above will also be applied to the secondary objectives.The collection of the nurses’ feelings of expertise will be synthesized.All analyses will be based on a first species error of 5% and will be two-tailed.The IBM®-SPSS® data analysis software (IBM Corp. Released 2015. IBM SPSS Statistics for Windows, Version 23.0. Armonk, NY: IBM Corp.) will support all analyses.