Psilocybin acutely increases small-world brain network structure and whole-brain integration
Further corroborating the delineated restructuring of the functional network reported in our study, global graph metrics demonstrated a significant increase in small-world structure after psilocybin administration, which was predominantly driven by optimized brain network integration (ΔL). Small-worldness characterizes the optimal organization present in the healthy brain, providing an ideal balance between regional and long-distance information flow [