Intervention
death, fever, malaria, malaria infection, respiratory syncytial virus
RTI, ADVERSE EVENTS, MALARIA, MALARIA, RESPIRATORY TRACT INFECTION
The trial intervention consisted of (1) diagnostic tests for common causes of fever in Burkina Faso (Diagnostic algorithm used in prescription decision making. Abbreviations: CBC, complete blood count; CRP, C-reactive protein (mg/L); GAS, group A streptococci; RSV, respiratory syncytial virus; RTI, respiratory tract infection; WBC, white blood cell count (per μL); WHO, World Health Organization.In the control arm, malaria RDT was the only diagnostic tool available for the diagnosis of fever episode as recommended by the National Malaria Control Program (PNLP) in standard practice. Except for malaria infection, the prescription of an antibiotic in the control arm was based on standard clinical practice based on clinical signs and symptoms. For children aged 6–59 months, the standard practice was the Integrated e-Diagnostic Approach (IeDA), which is based on Integrated Management of Childhood Illness (IMCI) guidance [In both arms, adverse events (AEs) or serious AEs (SAEs) were defined as no improvement, worsening, death, or requirement of hospitalization of the participant within 7 days of follow-up. In case of AEs or SAEs, the participant was excluded to follow-up and managed by the study clinician based on the national guideline.