Conclusion
PCOS
OXIDATIVE STRESS, OBESE, INSULIN SENSITIVITY
It was concluded that a prescribed hypo-calorie diet supplemented with 5 gr thylakoid membranes of spinach significantly decreased the serum LPS levels, increased the BDNF levels, improved the fasting blood glucose and insulin sensitivity, and exerted beneficial effects on the sex-hormonal status in obese individuals with PCOS. This intervention, however, failed to document significant changes in S100B and oxidative stress markers such as CAT, TAC, and MDA after 12 weeks of intervention.