Distal radius BMD
After 1 year, BMD of the 1/3 distal radius decreased significantly in both the group treated with MK-7 {−0.015 g/cmEffects of 2-years of supplementation with vitamin K2 (MK-7, 360 μg daily) or placebo: Bone mineral density of the distal radius. Mixed effect model analysis of changes in bone mineral density of the distal radius. (Effects of 2 years of supplementation with vitamin K2 (MK-7, 360 µg/day) or placebo: Significant changes in bone mineral density.Mixed effects model analysis of changes in BMD. Partly adjusted for gender and age; fully adjusted for baseline vitamin D and dp-ucMGP levels.After both 1 and 2 years of intervention, BMD of the mid, ultradistal and total distal radius decreased significantly in both the MK-7 and placebo groups, but without significant differences in mean changes or absolute BMD levels between groups (all Adjustments for gender and age, and additionally baseline vitamin D and vitamin K levels, did not modify the results of MK-7 supplementation on BMD in a stepwise model of any of the regions of the distal radius (Table 3 and Supplementary Table 7S).