Efficacy
Tumors, tumor, BOR of stable disease, SD
TUMORS, TUMOR, BEST
In Part 1 of the study, no patient had a best overall response (BOR) of complete response or PR, seven patients (50.0%) had a BOR of stable disease (SD). The median best percentage change from baseline in target lesion size was −2.6%. In Part 2, five patients (16.7%) achieved PR and 6 (20%) had SD. Median DOR among responders was 9.56 months (95% CI: 4.17, 14.95). The median of best percentage change from baseline in target lesion size was 15.2%. Best percentage changes in target lesion size for patients in Parts 1 and 2 are shown in Figure Best percentage change from baseline in target lesion size for patients in (A) Part 1 and (B) Part 2. Bar plots indicate percentage change in target lesion size and colors indicate the present tumor types. Corresponding best overall responses per Response Evaluation Criteria in Solid Tumors v1.1 are also presented. Responses by genomic alterations for all patients in Parts 1 and 2 are shown in Table 