Statistical methods
HCC
A minimum sample size of 45 patients with advanced HCC and 45 healthy controls was planned to study hemodynamic regulation. Statistical procedures were non‐parametric: Mann–Whitney U test and/or Kruskal–Wallis analysis of variance (ANOVA) for independent distributions; and Wilcoxon test and/or Friedman ANOVA for related distributions. EORTC QLQ–C30 analysis was performed according to the manual.