Patients
OPMDs
OPMDS, DISORDERS
This investigation was designed as a controlled randomized clinical trial. The study protocol was approved by the Institutional Ethics Board at Philipps-University Marburg, Germany (133/17; November 7, 2017). Planning and execution followed the rules in respect of the declaration of Helsinki. Informed consent was obtained from each patient after a detailed explanation of the nature, risks, and benefits of the clinical procedures to be performed. The study population comprised 40 patients with oral potentially malignant disorders (OPMDs) diagnosed by small incisional biopsy prior to inclusion to the study. The subjects were included from January 2020 to July 2020 according to the eligibility criteria. This trial was registered at German Clinical Trials Register (