Author contributions
R.H., A. E, and M.G. interpreted and wrote the initial draft, figure legends, and text descriptions of histological observations, and participated in the discussion. E.F. participated in writing the paper, data searching, preparing histological sections, and photomicrography. O.M., Y.M., B.A., M.A., R.A.-E., A.A.E. and K.A. carried out biochemical studies, analysis, and interpretation, and participated in manuscript writing. T.M., M.E., G.N., and W.M. participated in the analysis of biochemical results, correlated research findings, and wrote the final draft of the paper. S.M. and F.M. collected literature data and performed the morphometric study, analysis, and results correlation. All authors share in patient selection and follow-up, approved and revised the data and final version of the manuscript.