Pharmacokinetics
Adavosertib was steadily absorbed (median time to CSteady-state concentration at the RP2D (300 mg qd 5/2) was above the half-maximal inhibitory concentration (ICSystemic exposure to adavosertib appeared to be more than dose proportional (Supplementary Fig. S3). Power model estimates for cycle 1, day 1 were: AUCAdministration of a single dose of adavosertib with a high-fat meal did not appear to impact the C
Summary of food-effect analyses for the adavosertib bid dosing schedules and RP2Dbid 1 125 mg bid (5/9)bid 2150 mg bid (5/9)qd 3.2300 mg qd (5/2)AUC