Fracture Analysis in Relation to the Serum Levels of Lipid
MIN, vertebral fractures, fracture, vertebral fracture
Figure Subgroup analysis of the effects of treatment on vertebral fractures according to pre-specified subgroups. The forest plot of the minodronic acid (MIN) and raloxifene (RLX) treatments on the vertebral fracture incidence among the pre-specified fracture risk. The overall difference in incident vertebral fracture rate between MIN and RLX was not significant, but the subgroups of pre-specified background indicated that the MIN treatment showed a significant reduction in fracture risk compared to the RLX treatment, such as age ≥ 75 years (The association between the baseline serum levels and vertebral fracture incidence was estimated as IRR 0.94 [95% CI 0.74 1.22, Relationship between serum cholesterol levels and vertebral fracture incidence indicated by odds ratios after adjustment of age, BMD, and the number of prevalent vertebral fracture. The lines are depicted by spline curve of odds ratios. Bold and thin lines indicate MIN- and RLX-treated groups, respectively. The RLX-treated group showed higher odds ratio for incident vertebral fracture than those in MIN-treated group having higher LDL-C or lower HDL-C levels. The dotted lines indicated the 95% confidence intervals for each treatment arm. 