Pain Intensity at Days 1-2
pain
Differences in pain intensity between baseline (prior to treatment initiation on day 1) and after treatment (60, 120, and 180 minutes) over the first 2 days was assessed in the two groups and the results are summarized in Comparison of pain intensity between treatment arms on the first 2 days of participation. D: day; T: time (minutes after treatment use). ***As the number of active treatment users was drastically reduced from day 3 onward, only the first 2 days were included in the mixed model. Moreover, no difference was observed in the number of daily self-administrations between the two groups. On days 1 and 2, the mean pain intensity decrease at 60 minutes was 1.48 (SD 1.68) in patients using Endocare and was 0.92 (SD 1.28) in the control group.Compared to the initial (pretreatment) pain intensity levels, pain intensity reduction reached 51.6% (SD 35.34) at 120 minutes and 51.2% (SD 37.33) at 180 minutes on day 2 in the Endocare group versus 21.2% (SD 30.12) and 23.9% (SD 36.06), respectively, in the control group. Maximum pain intensity reduction was achieved on day 2 at 120 minutes after Endocare treatment administration.No significant group effect was observed (Contrast analysis revealed that pain intensity reduction was significant for each time point for the Endocare group compared to levels reported at day 1 before treatment and day 2 before treatment (To illustrate the efficacy of the study treatments under test, the percentage of patients achieving 20%, 30%, 50%, and 100% pain reduction at day 2, 180 minutes after treatment compared to the baseline was calculated (Patients achieving defined targets of pain intensity reduction at day 2, 180 minutes after treatment.