Study registration and design
intrabony defects of stage-III periodontitis
The current study was conducted in compliance with Helsinki Declaration for medical research involving human subjects as revised in 2013 as double-blind, parallel arms, and randomized controlled clinical trial, with 1:1 allocation ratio, to assess clinical and radiographic outcomes of I-PRF combined with DFDBA (I-PRF + DFDBA; test-group) versus DFDBA alone (DFDBA; control group) in surgical treatment of intrabony defects of stage-III periodontitis patients. The trial protocol was registered on 