Introduction
lung cancer, premature death
HEART DISEASE, CHRONIC BRONCHITIS, LUNG CANCER, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, DISEASES
Cigarette smoking is a leading cause of preventable premature death, and significantly increases the risk of developing lung cancer, heart disease, chronic bronchitis, chronic obstructive pulmonary disease and other serious diseases and adverse health conditionsThis publication is part of a three-part series describing the clinical assessment of Vuse Solo (cig-a-like ENDS). Vuse Solo has a rechargeable battery and has separate nicotine containing cartridges. The clinical studies included in this publication series describe the nicotine pharmacokinetics (PK) of Vuse Solo across four e-liquid flavors; an assessment of the abuse liability of Vuse Solo as compared to combustible cigarettes (CC) and a nicotine replacement therapy productWe report findings from a clinical study that was performed as part of a regulatory submission to the FDA CTP to assess the nicotine PK parameters of Vuse Solo flavor variants after a single ad libitum use in solus and dual users of cigarette and ENDS. The study data was reviewed by the FDA and granted a marketing order for Original (tobacco) flavor Vuse Solo ENDS cartridges and the Vuse Solo power unit as they deemed the product was appropriate for the protection of public health