Inclusion/Exclusion Criteria
psychiatric, ICHD-3
DISEASE, TENSION TYPE HEADACHE, SECONDARY, HEADACHE DISORDERS
Participants were eligible for the study if they (1) were aged between 18 and 60 years old, and (2) weighted from 50 to 100 kg. All female participants used a sufficient contraceptive method (contraceptive pill or intrauterine device/system). Exclusion criteria were (1) anamnestic and/or clinical signs of serious somatic or psychiatric disease, (2) diagnosis of primary or secondary headache disorder according to ICHD-3 (except tension type headache less than 5 days per month) [