Conflict of interest
E.F.J. de Vries declares Institutional financial support for contracted research from Hoffmann-La Roche, Eli Lilly, Bristol Myers Squibb, Ionis Pharmaceutical, Rodin Therapeutics, Lysosomal Therapeutics, Novartis and GlaxoSmithKline. These institutes were not involved in this study. All other authors declare that there is no conflict of interest.