Data and statistical analysis
hypoglycaemia
SECONDARY, HYPOGLYCAEMIA
The predefined primary outcome was the difference in hypoglycaemia-induced adrenaline responses from baseline following RT-CGM or RT-CGM+HIIT. As this was a pilot study, a formal sample size calculation was not carried out. The aim was to recruit up to 32 participants split equally between the two study groups. Because of the impact of the COVID-19 pandemic, 22 participants were recruited and 18 participants completed the experimental studies. Secondary outcomes examined were the difference in symptom awareness score, cognitive function and other CRR during hypoglycaemia following either RT-CGM or RT-CGM+HIIT. For the primary and secondary endpoints, a generalised estimating equation (GEE) was used, adjusting for baseline and euglycaemia (0 min). A 