What did the researchers do and find?
colorectal neoplasia, non-syndromic CRC
This multicenter randomized controlled trial included 870 asymptomatic FDR of patients with non-syndromic CRC. Participants were invited to participate through their affected index case(s).FDR were randomized (1:1) to one-time colonoscopy versus annual FIT during 3 consecutive years followed by a work-up colonoscopy in the case of a positive test.The rate of screening completion was similar in the group assigned to FIT and the group assigned to colonoscopy screening (36% versus 34%, respectively).The detection rate of advanced colorectal neoplasia was significantly lower in subjects receiving annual FIT than in those assigned to receive one-time colonoscopy.