Statistical analysis
Because this was a pilot feasibility study, sample size estimation was based on Fleming's multi-stage design [Data were recorded anonymously with REDCap software [Continuous variables were expressed as mean and standard deviation or the median and interquartile range, according to their statistical distribution. The assumption of normal distribution was tested by the Shapiro–Wilk test. Comparisons between randomization groups for quantitative variables (symptoms changes between values at day of intervention and those 24 h afterwards) were performed with Student's 