Differently expressed genes and pathways
tumors
TUMORS, PANCREAS
Differential expression analysis was performed to investigate the cellular processes that could contribute to the impaired prognosis and radiotherapy resistance in tumors with low protein levels of WRAP53. The analysis showed that 8100 genes were differentially expressed between tumors with low and high WRAP53 protein levels (C1). Of these, 5166 genes were enriched in tumors with high WRAP53 (e.g., ADH1B, FABP4, and FOSB) and 2934 in tumors with low WRAP53 (e.g., RPN2, ARF1, and CALR). GSEA showed that networks enriched in tumors with low WRAP53 related to the p53 pathway, DNA repair pathway, and apoptosis pathway among others (Fig. Gene set enrichment analysis (GSEA, Hallmarks database) depending on nuclear WRAP53 protein levels (C1‐antibody). Blue dots (left‐hand side) represent pathways enriched in tumors with low WRAP53 protein. Red dot (right‐hand side) represents the one pathway enriched in tumors with high WRAP53 protein (Pancreas beta cell pathway). The size of the dot corresponds to the size of the gene set.