Outcomes
death, intracranial disease, intracranial lesions
DISEASE, SECONDARY
The primary end point was intracranial PFS, defined as time from randomization to intracranial disease progression or death. The secondary end points included PFS, defined as time from randomization to overall disease (both intracranial and extracranial) progression or death; overall survival (OS), defined as time from randomization to death from any cause; intracranial objective response rate, defined as proportion of patients with complete or partial response of intracranial lesions; objective response rate, defined as proportion of patients with complete or partial response of overall lesions; and safety.