Cryo-EM structure of N751-2C06.01 in complex with BG505 DS-SOSIP reveals the antibody to bind at the fusion-peptide site of vulnerability
To define recognition details, we determined the cryo-EM structure of 2C06 in complex with BG505 DS-SOSIP. We obtained a 3D-reconstruction map at 2.95 Å from 645,442 particles utilizing C1 symmetry (Antibody 2C06 bound at the fusion-peptide site of vulnerability (The fusion peptide was flanked by CDRs H1 and H2 on one side and CDR H3 on the other (The 2C06 epitope also included S241, which is an Overall, the cryo-EM structure of 2C06 in complex with BG505 DS-SOSIP revealed 2C06 to bind at the fusion-peptide site of vulnerability, with heavy-chain CDRs accounting for most of the interactions with the fusion peptide.