STRENGTHS AND LIMITATIONS OF THIS STUDY
encephalitis
RECRUITMENT, ENCEPHALITIS
This was the first ever multicentre, randomised controlled trial evaluating intravenous immunoglobulin treatment for all-cause encephalitis in children.The study had clinically meaningful endpoints and was run to a very high standard, with rigorous blinding procedures throughout.Recruitment to the study was limited by the strict inclusion and exclusion criteria, the limited time window for enrolment and lack of equipoise among clinicians.