Statistical analyses
SECONDARY, CORTEX, REGRESSIONS
The distributions of demographic variables and PET scan parameters were visually compared between the groups and formally tested with a Welch two-sample As a secondary analysis, we investigated if there was an effect on [Group means for [As exploratory analyses, we investigated the effects of escitalopram versus placebo, intervention duration, and s-escitalopram concentration on hippocampus volume adjusted for age, sex, and intracranial volume (ICV). Lastly, for the neocortical subregions frontal, parietal, temporal, occipital, and insular cortex, we examined if there was a group and intervention duration effect on cortical thickness using linear regressions, as described for [All tests were performed as two-sided tests. Secondary and exploratory analyses were corrected for multiple comparisons according to the number of regions investigated, using the Bonferroni-Holm method. Statistical analyses were performed in R (v. 4.2.2).