Author contributions
MH, ZHZ
RECRUITMENT
YS is the principal investigator of this trial. WC, LH, YWL, and KL designed the trials and the study protocol. ZZ and SW drafted the manuscript. WC and LH contributed to critical review and revising of the report. ZZ, SW, YWL, and KL contributed to data interpretation and revising the manuscript. SW led laboratory analyses. SW, ZZ, PF, XS, YW, ZHZ, JX, YL, YHL, MH, GZ, SL, YZ, FS, YY and XFZ were responsible for laboratory analyses. BW was responsible for statistical analysis. TZ and JLZ contributed to study supervision. XWZ, JS, JZ, KF, PWL, PL, and ZQ led and participated in site work, including recruitment, follow-up and data collection. All authors contributed to the article and approved the submitted version.