Introduction
major depression, depressed
DISEASE
Transcranial direct current stimulation (tDCS) is an emerging neuromodulation technique that provides a safe, low-cost and non-invasive means of modulating the brainClinical trials investigating therapeutic effects of tDCS have shown mixed results. In major depression, Brunoni et al.In this study, we investigated whether serial tDCS therapy can induce persistent changes in brain structure in depressed participants. Regional reductions of gray matter measured with MRI are a well-replicated feature of disease processes in depressionStructural MRI data was acquired at baseline and after 12 sessions of tDCS treatment (referred to hereafter as post-treatment) from patients with major depression enrolled in a recently completed randomized, double-blind and sham-controlled clinical trial (Fig. Study diagram. (