Definition of microvascular events: Development or progression of microvascular complications
retinopathy, micro-/macroalbuminuria, CKD, albuminuria
RETINOPATHY, EVENTS, COMPLICATIONS
Preliminary definitions of microvascular events in the SMARTEST study were adopted.Thus, progression of CKD stage was defined as a decline in eGFR, calculated with the 2009 CKD-EPI formula,Development or progression of albuminuria, foot complications and retinopathy were defined as the progression to a higher stage (i.e. from no albuminuria to micro-/macroalbuminuria or from micro-to macroalbuminuria) from the highest of the inclusion visit assessment and the last NDR entry or EHR data, respectively, within 18 months that was either repeatedly observed on at least one consecutive and non-identical observation OR the last available observation OR, for albuminuria, normalized after initiation of RAAS-blockade therapy. Observations were only counted as events if > 30 (>90 for retinopathy) days from randomization to date of examinations (foot-at-risk, retinopathy) or register entry (albuminuria). For foot-at-risk and retinopathy, the date of examinations was converted to the 15