DISCUSSION
TAVI, SIRS, aortic valve stenosis, aortic stenosis, MP, stenosis, trauma
PCT, INFLAMMATION, AORTIC VALVE STENOSIS, AORTIC STENOSIS, STENOSIS, INFLAMMATORY RESPONSE
Studies report a high incidence of SIRS in the immediate postoperative period of
surgical valve replacement, and it is directly related to surgical trauma and the
use of CPBRegarding the effect of aortic stenosis treatment in the mid-term follow-up, a
prospective study in 56 symptomatic patients with significant aortic valve stenosis
undergoing TAVI, with determination of EMP and platelets by flow cytometry, in the
three-month postoperative follow-up showed a decrease in MP levels compared to the
preoperative period; the treatment of aortic valve stenosis by TAVI was associated
with improved function and endothelial integrity, indicating beneficial effects of
TAVI on systemic arterial functionNevertheless, in our study, when assessing EMP levels (MP CD31+, CD42b-, CD144+) in
the three-month postoperative period, we observed a significant decrease in relation
to the 24-hour postoperative period (Regarding IL-6 levels, a study in Spain evaluating the inflammatory response in
patients undergoing surgical aortic valve replacement with conventional
Data supported by Goetzenich A, et al.Studies in patients with aortic valve stenosis undergoing aortic valve replacement
with conventional surgery and TAVI via the transapical and transfemoral routes
showed an inflammatory response in all groups, with higher levels of plasma
leukocytes, CRP, IL-6, and IL-8 in the conventional and transapical transcatheter
surgery groups when compared to the transfemoral route. These results suggest less
inflammation after transfemoral proceduresSinning JM et. al, in a study of 152 elderly patients with symptomatic severe aortic
stenosis undergoing TAVI, showed a 40% occurrence of SIRS during the first 48 hours
after the procedure, characterized by a significantly elevated release of IL-6 and
IL-8, with subsequent increase in leukocytes, CRP, and PCTData like the findings of our study, where we found a high incidence of SIRS, and in
relation to the levels of IL-6, IL-8, plasma leukocytes, CRP, and PCT, showed a
significant increase in the postoperative period of 24 hours, when compared to the
preoperative period.