Limitations
This RCT has several important limitations. First, the sample size of the trial was small; the study included 140 participants and found no differences between the two groups in the Ua lactate (MD 0.3 mmol/L, 95% CI −0.2 to 0.9). To detect the 0.3 mmol/L difference in Ua lactate with 80% power and a 2-sided test of 0.05, we estimated that 450 women were needed in each group. Second, the main outcomes were not patient-relevant end points (