Statistical analyses
Experimental data were processed by statistical product and service solutions (SPSS) 26.0. Data are summarized as the mean (standard deviation), median (interquartile range [IQR]), or number (%). Categorical data were analyzed with Fisher’s exact test or the X2 test. The measurement data adopts the analysis of repeated measure date ANOVA, One-way ANOVA and T-test. Two-sided Patients enrollment diagram