Safety
anxiety, hypomanic, bipolar disorder, visual hallucinations, decreased appetite
RIGHT BRANCH BUNDLE BLOCK, EVENT, URINARY INCONTINENCE
AEs were observed in 15 (60.0%) of 25 patients in the zonisamide add-on group and 14 (58.3%) of 24 patients in the levodopa increase group. One patient (4.0%) in the zonisamide add-on group had two ADRs (anxiety and urinary incontinence), and four patients (16.7%) in the levodopa increase group had one case each of decreased appetite, visual hallucinations, bipolar disorder, and right bundle branch block. No serious ADRs were observed in the zonisamide add-on group, and one serious ADR (bipolar disorder) was observed in the levodopa increase group. In the latter case, the patient had a medical history of bipolar disorder. As the episode of bipolar disorder (i.e., hypomanic symptoms) worsened after the levodopa dose was increased, the event was classified as an ADR. No ADRs leading to discontinuation of the study were observed in the zonisamide add-on group. ADRs leading to discontinuation were observed in three patients in the levodopa increase group (exacerbation of bipolar disorder, decreased appetite, and visual hallucinations).Regarding the NPI-12 total score at 24 weeks (