Endpoints
death
DISEASE PROGRESSION
The primary endpoint was the ORR, defined as the percentage of patients with a confirmed complete response (CR) or partial response (PR) according to the Lugano 2014 response criteria. Secondary endpoints included duration of response (DoR, defined as the time from first documented objective response to disease progression or death from any cause); PFS, (defined as the time from the first dose to disease progression or death from any cause, whichever occurred first); overall survival (OS, defined as the time from the first dose to death from any cause); and the correlation between the expression of biomarkers such as PD1/PD-L1 and clinical outcomes.