Associations of genetic AF and stroke risk with trial outcomes
stroke, incident disease, cardiovascular death, ischaemic stroke
ISCHAEMIC STROKE, ATRIAL FIBRILLATION, STROKE, ACUTE CORONARY SYNDROME, REGRESSION
The continuous genetic risk for AF was not associated with the primary composite outcome (cardiovascular death, stroke, hospitalization for worsening of HF, and acute coronary syndrome) (HR 0.99, 95% CI: 0.88–1.11, Association of AF genetic risk (PRS-AF) categories classified by quintile and occurrence of the primary composite endpoint, occurrence of recurrent AF, occurrence of stroke and hospitalization for worsening of HF. Hazard ratios and Association of PRS-AF as a continuous variable with cardiovascular outcomes in the EAST-AFNET 4 trialThe continuous genetic risk for stroke showed an association with the primary composite outcome (HR 1.13, 95% CI: 1.0–1.27, Association of genetic risk for ischaemic stroke (PRS-stroke) categories classified by quintile and occurrence of the primary composite endpoint, occurrence of recurrent AF, occurrence of stroke, and hospitalization for worsening of HF. Hazard ratios and Association of PRS-stroke as a continuous variable with cardiovascular outcomes in the EAST-AFNET 4 trialHazard ratio as 1 SD change of the PRS on the risk of an outcome, calculated using Cox regression models adjusted for treatment group and with centre as a shared frailty term.To further investigate this finding, we applied the PRS-stroke to up to 407 311 UKB participants, where we found an association of the risk score with incident HF (Association of PRS-stroke with incident disease in the UK biobank using adjusted cox regression models. Hazard ratio as 1 SD change of the PRS on the risk of incident diseaseAF, atrial fibrillation.