Methods in analysis to handle protocol non-adherence and any statistical methods to handle missing data
SECONDARY
Each participant’s consumption of the ONS will be monitored on a weekly basis to assess adherence to the intervention. If a participant is unable to consume the supplement continuously for more than five days due to hospitalization or any other reason, they will be considered as “non-adherent” to the intervention. Using Multiple imputation methods accessible in SPSS, the primary outcome data of the participants will be randomized to the intervention but non-adherent participants will be imputed [We expect the proportion of missing data to be below 5% for the primary outcome. We will not perform multiple imputations for the primary outcome unless more than 5% of the data are missing. The secondary outcomes will be assessed in a full analysis set.