2.8. Statistical Analysis
All parameters were evaluated using descriptive statistics (mean, standard deviation, percentile, medians, min and max).For age cohort 18–60, the sample size was determined based on the requirements of the national guidelines, and the distribution of the participants between Vaccine Group and Placebo Group was 3:1.Value comparisons (for example, GMT) were made using ANOVA or Mann–Whitney tests. For age cohort 18–60, variance analysis with repeated measures was used to analyze changes in quantitative indices measured more than 2 times over time. For posterior comparisons, a paired Bonferroni-corrected 