2.3. Inclusion and exclusion criteria
Systemic disorders, allergy, caries, DMFS, tooth
SEVERE PERIODONTITIS, ALLERGY, CARIES
The following inclusion and exclusion criteria were applied:A) Inclusion criteria• Provision of written informed consent.• Age 18-45 years (both men and women).• A minimum of 10 caries-free (DMFS index=0) molars and premolars.• Willing to use an electric (powered) toothbrush.B) Exclusion criteria
• Untreated caries (subjects with untreated caries in need of restoration can become eligible after restorative therapy).• Severe periodontitis at the baseline visit (pocket depth on at least one tooth ≥ 5.5 mm).• Undergoing orthodontic treatment.• Known allergy to one of the ingredients of the study toothpastes.• Systemic disorders interfering with salivary function or flow rate.• Regular medication intake interfering with salivary function or flow rate.
• Participation in any other clinical study within the past 3 months or ongoing.• Lack of intellectual or physical ability to conduct the study per protocol.• Any other reason that, in the opinion of the investigator, disqualifies the subject from participating in the study.