Conclusions
MDD
This study found longitudinal associations of SSRI treatments with both volume and rsFC in the DLPFC of adolescents with MDD using a relatively large sample. More significant longitudinal changes in the DLPFC volume and rsFC in responders may be potential treatment markers of neural plasticity that can mediate the effects of SSRI treatment or be modulated by the beneficial effects of SSRI treatment. Therefore, our findings, while preliminary, underscored the importance of the DLPFC volumetric and rsFC changes as potential neurobiological treatment markers that are associated with symptom improvement in adolescents with MDD.