In vivo study design.
pericarditis
STERILE, PERICARDITIS
To reflect the real-world context and probe for sex-based (biological) differences, the study was performed in both female and male middle-aged rats. Middle-aged Sprague-Dawley rats (6 months old, Charles River Laboratories) of both sexes underwent induction of sterile pericarditis or sham operation under a protocol approved by the University of Ottawa Animal Care Committee. The detailed protocol was registered a priori within the Open Science Framework (