Research objective and outcomes
gastrointestinal failure
GASTROINTESTINAL FAILURE, RESPIRATORY FAILURE, EVENT, ACUTE RENAL FAILURE, NOSOCOMIAL INFECTION, COMPLICATIONS
We had three main goals for this analysis: first, to investigate how nutritional therapy impacts on the short-term changes in serum albumin concentrations from baseline to 7 days in the overall population and within subgroups of patients with high and low baseline albumin concentrations ( < 30 g/L or ≥ 30 g/L) [Our primary endpoint for the prognostic analyses was long-term all-cause mortality measured over 180 days, while for the response to nutritional support we focused on short-term 30-day mortality. Secondary endpoints where adverse outcome within 30 days (composite endpoint consisting of all-cause mortality, admission to the intensive care unit from medical ward, major complications (nosocomial infection, respiratory failure, major cardiovascular event, acute renal failure, gastrointestinal failure), nonelective hospital readmission after discharge, decline in functional status ≥10% measured by Barthel’s index), length of hospital stay, loss of function according to Barthel’s index (score ranging from 0 to 100 with lower scores indicating worse functional status) and quality of life measured by 5-level European Quality of life 5 Dimensions index (EQ5D) including the self-assessment visual analogue scale (VAS). Detailed information for the single endpoints and their composites is summarized in the Supplement. We defined treatment response as the difference in outcomes among control group and intervention group patients, similar to the initial EFFORT trial.