Secondary analyses examining treatment and time effects
depression
We observed a single significant three-way interaction between resting-state connectivity, treatment, and time (full statistical details in online Supplementary Table S2). Greater connectivity between the right mPFC and left rACC was associated with lower MADRS scores over time in the escitalopram arm, but less change in MADRS score over time for those allocated to placebo (Secondary analyses of change in depression severity based on functional connectivity patterns. (After removing the three-way interaction term, we tested for an interactive effect between resting functional connectivity and time predicting MADRS score. We observed a significant interaction between PCC – left hippocampal connectivity and time (