Discussion
vulvovaginal candidiasis, ’ vaginal
RECURRENCE, VAGINA, VULVOVAGINAL CANDIDIASIS
The colonization of lactic acid bacteria plays an important role in maintaining vaginal homeostasis by inhibiting other pathogens, and the colonization of anaerobic bacteria is often related to the occurrence of BV (A randomized, double-blind, placebo-controlled trial evaluated the routine treatment of BV or vulvovaginal candidiasis for five days with probiotic capsule, revealing improvement in symptoms, which was accompanied by lactobacilli colonization of the vagina, reduced recurrence rate, and reduced odor in the vaginal discharge, which is consistent with our findings (In this study, we found no significant difference in the α diversity of vaginal microbiota showed a non-significant reduction after using the postbiotic gel. It is important to note that, contrasting to the gut microbiota, a healthy vaginal microbiota has a low bacterial diversity. A high vaginal microbiota diversity increases the probability of BV (
Then, a correlation analysis was performed between the dominant genera of the vaginal microbiota and properties of subjects’ vaginal secretions. Again, we found a significant negative association between lactobacilli and potential pathogens like In conclusion, our study showed that applying the current postbiotic gel could improve the patients’ symptoms of BV, and the symptom improvement was accompanied by significant changes in patients’ vaginal microbiota, characterized by an increase in lactobacilli and a reduction in multiple potential vaginal pathogens. Our data supported that postbiotics application could improve vaginal health and ease BV. Our findings have a high application value in clinical practice.