Discussion
Ottawa bowel preparation, chronic constipation, bowel preparation, constipation, Inadequate bowel preparation, adenoma
DISEASE, ADENOMA
Colonoscopy is currently considered a standard and the most commonly used method for the screening, diagnosis, and treatment of disease. Inadequate bowel preparation directly affects the adenoma detection rate and adenoma missed rateThe success of bowel preparation in this study was very low (50% in the study group and 52.9% in the control group). Since the effect was not clearly different, it may be that the duration of the drug may have been too short, resulting in poor efficacy of lubiprostone. This is consistent with a study by Johanson et al.Overall, the results show that the quality of bowel preparation in both groups was poor. This was different from the results reported by the latest study from Srinagarind Hospital that evaluated the use of triple-dose PEG-ELS compared with standard split-dose PEG-ELS for bowel preparation in constipation patients and found that triple-dose PEG-ELS achieved successful bowel cleansing compared with split-dose PEG-ELS (91.4% vs. 73.0%, In the past 5 years, there have been many studies on bowel preparation, and it has been found that for patients with chronic constipation, bowel preparation is difficultBisacodyl plus split-dose 2 L PEG plus simethicone compared with split-dose 4 L PEG showed no significant differences in bowel preparation. However, the combination performed better than the standard regimen in terms of colonic mucosa visualization, patient acceptance and compliance.Lactulose 30 ml plus split-dose 4 L PEG has been shown to be significantly superior to the conventional method for colonoscopy bowel preparation in patients with constipation. However, the Ottawa bowel preparation score improved only to 8.40 ± 0.84In the present study, we found no clinically significant difference in efficacy between the 2 regimens, which is different from recent studies that showed that lubiprostone plus PEG-ELS in patients without constipation benefited from improved bowel cleansingTo our knowledge, our study is the first to evaluate the combination of lubiprostone with split-dose PEG-ELS in constipation patients. However, a limitation is that this study was performed in single and tertiary care settings that may not represent all constipation patients.