Strengths and limitations of study
asthma
REGRESSION, ASTHMA
The strengths of this study include that it is the largest population of infants born to mothers with asthma in which eNO has been measured at six weeks of age. These infants are at increased risk of asthma in later life and may be more susceptible to air pollutants [A limitation of this study is that the single location used for measuring air pollution does not provide an exact assessment of the outdoor air pollution at the infant’s home address or household air pollution exposure. However, all infants were living within the local region at the time of their test. Nonetheless, the use of daily regulatory monitoring data along with land-use regression models capable of predicting the spatiotemporal variation in pollutants could further improve the precision of individual exposure estimates.Another potential limitation is that any potential effect from prenatal air pollution exposure has not been accounted for, whereas other studies have described associations between eNO in infants and prenatal air pollution exposure [There were issues with equipment failure and lack of access to NO-free air, but we are confident that this did not induce selection bias as it occurred at random.