Study design
RCC, NCT04564859
RCC
This single-center, prospective, nonblinded RCT and equivalent RCT that compared NIPPV (intervention group) and HFNC (control group) after extubation was conducted between January 2017 and December 2020 at the respiratory care center (RCC) of Shin Kong Wu Ho-Su Memorial Hospital in Taipei, Taiwan. The study was approved by the Institutional Review Board of Shin Kong Wu Ho-Su Memorial Hospital (IRB number: 20160901R), and written informed consent was obtained from all the participants or their relatives. The trial was registered at ClinicalTrials.gov (NCT04564859 25/09/2020).