Biomarker consideration
Alzheimer’s disease
The biomarkers that were selected a priori were the fluid biomarkers that were the primary outcome objectives of the parent study. These biomarkers were blood CD8 + T lymphocyte activation and blood and CSF dopamine and BDNF. The post hoc biomarkers were the neurofilament light chain and Alzheimer’s disease–related biomarkers. All analytes (individual biomarkers or protein) were processed in single batches or one group using the same equipment, reagent, and technician.