Interpretation
irregular bleeding, mastalgia, DIE, cancer, nausea &vomiting
REGRESSION, CANCER
A fourth-generation progestin called DIE was employed in hormone replacement treatment and contraceptive pills [It is well known that progestins speed up the signaling pathways that prevent endometrial cells from undergoing cancer development [A research by Kodama et al. [Ozdegirmenci et al. [In the current study, we used DIE 2 mg/day for 14 days/cycle orally versus NETA 15 mg/day for 10 days/cycle orally in patients with EH without atypia for six months. We found that DIE group showed a higher rate of resolution (38.5%) and regression (57.7%) than NETA group (31% & 37.9%, respectively) with significance regarding regression only (The same results reported by Uysal et al. [Also, our results revealed that side effects of DIE & NETA were comparable between groups with slightly higher rate in NETA group for irregular bleeding, nausea &vomiting and mastalgia. The same finding recorded in Uysal et al. [