2.2. Pharmacophore modelling
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The pharmacophore model was generated using the three-dimensional quantitative structure-activity relationship (3D-QSAR) based pharmacophore approach. The HypoGen module of Discovery Studio® (DS) [Above mentioned features were used to generate 10 hypotheses with the minimum of zero to the maximum of 5 features for each PPAR utilizing the 3D-QSAR protocol of DS. For hypothesis generation, the energy threshold for conformational generation for each compound was maintained at 10 kcal mol