INTRODUCTION
fatigue, fever, inflammation, erythema, pustular, sepsis
PATHOLOGY, SKIN DISEASE, GENERALIZED PUSTULAR PSORIASIS, INFLAMMATION, ERYTHEMA, RENAL FAILURE, STERILE, CONGESTIVE HEART FAILURE, SEPSIS, ACUTE RESPIRATORY DISTRESS SYNDROME, LEUKOCYTOSIS, COMPLICATIONS, ERUPTION
Generalized pustular psoriasis (GPP) is a potentially life‐threatening neutrophilic skin disease characterized by recurrent flares of widespread erythema with eruption of sterile pustules that can coalesce to form lakes of pus.GPP flares may be associated with systemic inflammation and can present with symptoms such as fever, fatigue, and leukocytosis. Consequently, there can be a severe impact on patient quality of life and there are risks of serious complications requiring hospitalization, such as sepsis, acute respiratory distress syndrome, renal failure, and congestive heart failure.Evidence suggests that the interleukin (IL)‐36 pathway plays a key role in the pathology of GPP, and several studies have indicated that Asian patients with GPP have high rates (46.8%–81.8%) of mutations in In the Effisayil™ 1 study (NCT03782792), patients with a GPP flare treated with spesolimab, a humanized anti‐IL‐36 receptor monoclonal antibody and the first targeted treatment for GPP to be studied in a randomized clinical trial, achieved rapid pustular and skin clearance with an acceptable safety profile.