Introduction
depression, gastrointestinal tract, Hypothyroidism
METABOLIC DISEASES, HYPOTHYROIDISM
Hypothyroidism affects up to 5% of the general population [Synbiotics have been advocated as being beneficial to patients with metabolic diseases. Synbiotic refers to a mixture of probiotics and prebiotics that beneficially affect the host by improving the survival and stimulating the growth of advantageous and health promoting microbial species in the gastrointestinal tract [Through the mentioned mechanisms of action, synbiotic plays a major role in the modulation of the intestinal flora, and thus, it could indirectly affect the production of thyroid hormones. Also, according to the literature, synbiotic could improve depression, quality of life [