MATERIALS AND METHODS
Both the pilot and efficacy studies were single‐center, controlled, randomized, crossover trials conducted at a US‐based clinical research facility in full compliance with the International Council for Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use, all applicable local good clinical practice regulations and participant privacy requirements, and the ethical principles outlined in the Declaration of Helsinki. The pilot study (ClinicalTrials.gov: NCT03345108) was an open‐label, three‐treatment, three‐period study. The efficacy study (