Study design and participants
This study was a multicenter, randomized, parallel-group clinical trial with participants allocated in a 1:1:1:1 ratio to normal control (NC) diet, low-carbohydrate (LC) diet, calorie-restricted (CR) diet, or LC + CR diet for 12 weeks. The randomization schedules were generated using a centrally controlled, computer-generated random number Internet-based system and concealed until an eligible participant was ready for enrollment.All study participants were recruited from 13 hospitals in Guangdong Province, China, from April to July 2018. The trial protocol is available in Additional file The study was approved by the institutional review board of Zhujiang Hospital of Southern Medical University and registered at the China Clinical Trial Registration Center (