Author Contributions
F.R.M. conceptualized the aims and approach of this paper with the review and approval of E.J.M.-D., J.C., A.E.S.-R., S.R.S., D.M.M., M.S. and K.R.E. Analyses were performed by F.R.M. with consultation by senior statistician J.C. Preparation of the manuscript, figures, and tables was performed by F.R.M. with review, editing, and approval from all co-authors. All authors have read and agreed to the published version of the manuscript.