Data collection
metabolic acidosis, hyperchloremia
METABOLIC ACIDOSIS, BLOOD, HYPERCHLOREMIA, RENAL DISEASE
We collected some physiological measurements to describe metabolic status. From the inclusion to day 4, the following parameters were collected daily: chloride, potassium, pH, bicarbonate, lactate, urea and creatinine. Blood sodium levels were collected from inclusion to Day 10. For these metabolic parameters, the worst value each day was collected. The highest weekly creatinine levels were collected from inclusion to Day 28. We calculated Glomerular Filtration Rate (GFR) according to the Modification of Diet in Renal Disease (MDRD)-175 equation. Estimated Glomerular Filtration Rate (eGFR) was calculated daily from inclusion to Day 4, and the worst eGFR each week from Week 1 to Week 4. The proportion of patients exposed to hyperchloremia (chloride level ≥ 110 mmol/L) was also reported. We defined metabolic acidosis using the following parameters: pH < 7.35 and bicarbonate level < 22 mmol/L. Urine outputs were collected from inclusion to Day 4. We also collected the amount of chloride received daily (g/day) during the first 4 days.