Introduction
tumor, somatotropinoma, Somatotropinomas, acromegaly, Acromegaly, chronic progressive disease
ORPHAN DISEASE, RARE DISEASE, TUMOR, POSTOPERATIVE COMPLICATIONS, DISEASE, REMISSION, SOMATOTROPINOMA, ACROMEGALY, ACROMEGALY, COMPLICATIONS
Somatotropinomas are the main cause of acromegaly, a chronic progressive disease associated with hypersecretion of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) (Acromegaly is a rare disease (orphan disease) which affects women and men equally often (In Bulgaria, for example, the prevalence of acromegaly is 49 cases per 1 million (Changes in the musculoskeletal system at acromegaly are associated with the GH and IGF-1 levels, playing a vital role in the regulation of cartilaginous and osseous tissue homeostasis, bone growth in length, and the increase in the mass of osseous tissues (Mortality without adequate treatment is 2.0 to 4.0 times greater than in the general population (Given the seriousness of the disease and the high percentage of systemic complications, deteriorating a patient’s life quality, timely and correct treatment of acromegaly is significantly crucial (Surgery is the primary and most efficient method of treatment. It can result in a stable and rapid remission of acromegaly (In recent years, transcranial access has been used infrequently. Most somatotropins are removed through transsphenoidal access when the tumor is small or medium in size. The endoscopic technique development has made it possible to endonasal transsphenoidal somatotropinoma removal with an endoscope. This technique reduces the risk and increases the radicality of the surgical procedure (The study aimed to compare the radicality of small-sized and medium (<30 mm) somatotropinoma removal and the incidence of postoperative complications in patients with acromegaly when using microscopic and endoscopic techniques.