Patients
ST-T depression, scalp nerve block, cranial suture, infection, left atrial enlargement, hypersensitivity
CONGENITAL DISORDERS, INFECTION, LEFT VENTRICULAR HYPERTROPHY, BUNDLE BRANCH BLOCK, CRANIOSYNOSTOSIS, HYPERSENSITIVITY, NEUROLOGICAL DISORDERS
The study was performed between Oct 1, 2021, and Oct 1, 2022. Written informed consent was obtained from the parents or relatives of patients. A total of 60 children (ASA I or II, aged 6 months to 24 months) who were scheduled for elective cranial suture reconstruction in the Department of Neurosurgery in Shanghai Children's Hospital were enrolled in this study. Exclusion criteria were as follows: hypersensitivity to ropivacaine, neurological disorders (except for craniosynostosis), local infection at the predesigned puncture site, diagnosis with other congenital disorders, participation in other clinical studies within 4 weeks before surgery, and abnormal electrocardiograph (ECG; presence of 1 or more of following features: bundle branch block, conduction delay, signs of right or left ventricular hypertrophy or left atrial enlargement, prolonged QTC interval, or ST-T depression exceeding 0.5 mm and/or pathological Q waves). Patients were randomly allocated into two groups by using computer-generated random numbers: Group A (general anesthesia combined with scalp nerve block) and Group N (general anesthesia). This was a single-center study designed according to the CONSORT statement and approved by the Institution Review Board (Ethics Commission of Children’s Hospital of Shanghai, Ref. No. 2021R029-F02; registered at the China Clinical Trial Registry Center, registration number ChiCTR2200066131).