References
Anxiety, abdominal pain, IBS-D, diarrhea-predominant irritable bowel syndrome, Depression
Comparison of nutritional intervention results between the two subgroups of IBS-D patients (Red bars, group IIA without and green bars, IIB with tryptophan limitation intake); GSRS—Gastrointestinal Symptom Rating Scale; HAM-A—Hamilton Anxiety Rating Scale; HAM-D—Hamilton Depression Rating Scale; Percent improvement was calculate. *** Correlation between daily TRP intake (mg/kg b.w.) and the intensity of abdominal pain (GSRS score) after nutritional treatment of IBS-D patients without (General characteristics and the selected biochemical blood parameters and tryptophan intake in the control group (GFR—glomerular filtration rate, ALT—alanine aminotransferase, AST—aspartate aminotransferase, CRP—C-reactive protein, FC—fecal calprotectin; TRP—tryptophan intake; data are presented as average ± SD; differences between groups were not significant.Urinary levels of tryptophan (TRP) and its metabolites: 5-hydroxyindoleacetic acid (5-HIAA), kynurenine (KYN), kynurenic acid (KYNA), and quinolinic acid (QA) in the control group and patients with diarrhea-predominant irritable bowel syndrome (IBS-D); all results expressed in units—mg/gCr; average ± SD.Comparison of severity of symptoms between the two subgroups of IBS-D patients (Groups IIA and IIB); GSRS—Gastrointestinal Symptom Rating Scale; HAM-A—Hamilton Anxiety Rating Scale; HAM-D—Hamilton Depression Rating Scale; average ± SD.Comparison of severity of symptoms between the two subgroups of IBS-D patients (Group IIA without and Group IIB with tryptophan limitation intake) before and after nutritional intervention; GSRS—Gastrointestinal Symptom Rating Scale; HAM-A—Hamilton Anxiety Rating Scale; HAM-D—Hamilton Depression Rating Scale; average ± SD.Urinary excretion of tryptophan (TRP) and its metabolites: 5-hydroxyindoleacetic acid (5-HIAA), kynurenine (KYN), kynurenic acid (KYNA), and quinolinic acid (QA) in patients with diarrhea-predominant irritable bowel syndrome without (IIA) and with (IIB) reduction of TRP intake; before (a) and after (b) nutritional intervention; all results expressed in units—mg/gCr; average ± SD.