Introduction
glaucomatous, uveitis, glaucoma, OAG, glaucomatous damage, vision loss
UVEITIS, OPTIC NERVE, PATHOPHYSIOLOGY, RETINA, OPEN ANGLE GLAUCOMA, DISORDERS, HIGH MYOPIA, GLAUCOMA
Open angle glaucoma (OAG) is considered the second leading cause of irreversible vision loss globally [The pathophysiology and factors contributing to glaucoma progression have not been fully understood [Optical Coherence Tomography Angiography (OCTA) and adaptive optics-OCT are promising current tools for diagnosing and management of glaucomatous patients. OCTA can measure the blood flow within the retina and the optic nerve, and thus can assess the degree of glaucomatous damage and evaluate the health of the ganglion cells and their axons [Recent publications using OCTA had mainly focused on evaluation of the microcirculation inside the optic disk and in the peripapillary area and displayed reduction of the peripapillary microcirculation [The photopic negative response (PhNR) is an objective, minimally-invasive test that reflect the function of RGC and their axons. It can be reduced in glaucoma and disorders that affect the inner-most retina [Structural OCT measurements have limited diagnostic ability in identifying early stages of OAG, especially in patients with atypical optic nerves as in high myopia or uveitis and have moderate correlation with visual field testing [Controversy regarding the associations between the vascular, functional and structural parameters in OAG is still present and the sensitivity of these parameters varies greatly. Some studies have found stronger associations between vascular and functional parameters rather than structural ones [The aim of the present study was to evaluate the correlations between vascular, functional and structural changes of the peripapillary RNFL and macular/ganglion cell complex in OAG patients and assess the diagnostic accuracy of OCTA and PhNR parameters in early detection of glaucoma changes.