Assessment
pain
ADVERSE EVENTS, ADVERSE EVENT
According to a previous study [34], all patients were required to use a diary to record pain intensity using the VAS scores immediately before and 5 and 15 min after the first use of ibuprofen or placebo gargle. Moreover, they recorded the number of times of gargle use daily and any other treatment‐related adverse events (TRAEs). Safety was assessed based on data from the patients' diaries and physician's consultation records. The safety assessment period was extended from the start of gargle use until PODs 6–10 after discontinuation, following the Common Terminology Criteria for Adverse Events version 5.0 (