4. Discussion
TG
REGRESSION, CHRONIC INFLAMMATION
We investigated the effects of consuming a dairy drink containing a synbiotic comprising After 12 weeks of consuming a dairy beverage containing GCL2505 and inulin, the reduction in VFA from week 0 to weeks 8 and 12 in the active group was significantly greater than that in the placebo group. Although there was no significant group difference in the reduction in SFA, the reduction in TFA was significantly greater compared with the placebo group, thus confirming the reduction in overall abdominal fat due to ingestion of the synbiotic. In addition, quantification of fecal bifidobacteria showed that total bifidobacteria, At weeks 4 and 8, TG in the active group was significantly lower compared with the placebo group, suggesting an effect of GCL2505 and inulin intake on lipid parameters in plasma. In addition, body weight and BMI at week 12 as well as TC, LDL-C and HDL-C at week 8 in the active group were significantly lower compared with baseline. Changes in body weight and BMI were also reported in a meta-analysis by Koutnikova et al. [The differences in TG between groups at week 8 may be due to the action of SCFAs. It was suggested that SCFAs promote lipid clearance in the liver by downregulating angiopoietin-like protein 4, which inhibits lipoprotein lipase [The relationship between parameters such as VFA and TG (which changed in this study) as well as the number of bifidobacteria were estimated by regression analysis and applying analysis of variance to a mixed effects model. The results suggest that an increase in total bifidobacteria count is significantly associated with a decrease in BMI and VFA, whereas an increase in Accumulation of visceral fat induces chronic inflammation. Recent studies have reported that intake of GCL2505 and inulin suppresses chronic inflammation, thereby improving cognitive and vascular function [