Author contributions
RECRUITMENT
All authors contributed to the study conception and execution. Patient recruitment, sample preparation and data collection were performed by CS, NC, DS, ER, LF, SG, XZ, AKR and BRB, HS and DZ. HE and HR contributed to study planning and implementation. KMK and CS are the principal investigators and designed the study. The data analysis was performed by NC. The first draft of the manuscript was written by NC and CS. All authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.