Impact on clinical practice
DISEASE
Implementation of these models may be impacted by the availability of resources. Feverkidstool includes the result of a POC CRP test, which may not be readily available at all sites. Pulse oximetry and measurement of other vital signs in children, useful for Feverkidstool, the SBI score and especially the physiology-based risk score PAWS, are often not routinely available in primary care. The other variables are easy to determine after proper history taking and clinical examination and applicable across different settings and healthcare systems. The Craig model, consisting of 26 clinical signs and symptoms, only requires a thermometer, a stethoscope and an otoscope. The LRMs Feverkidstool, Craig model and SBI model require a simple software application.The Feverkidstool and the Craig model can support clinical reasoning and the decision-making process of physicians. Combining the numerous findings from history taking and clinical examination at various stages of disease is challenging and may lead to underestimation of SI by discarding information [For primary care, these models could be calibrated to be more accurate at lower risk thresholds, making them more suitable for the exclusion of SBI at the cost of more false-positive results and less accurate predictions in higher probability ranges [