Research methods
All patients in the group received a multi-day chemotherapy regimen of cisplatin, and the total dose of cisplatin was calculated according to 75 mg/m2, which was divided into days d1-3. The triple antiemetic regimen in the olanzapine group was: olanzapine 5 mg for 1–4 days, dexamethasone 10 mg for 1–3 days, and tropisetron 5 mg for 1–3 days. The triple antiemetic regimen of the aprepitant group was: aprepitant 125 mg on day 1 and 80 mg on day 2 and 3, dexamethasone 5 mg on day 1–3, and tropisetron 5 mg on day 1–3. Studies have shown that aprepitant can moderately inhibit CYP3A4 enzymes, interfere with the pharmacokinetics of dexamethasone and increase its blood concentration. So in contrast to the olanzapine group, the dexamethasone dose was halved in the aprepitant group [