Background
neurological disease, headache, migraine, Migraine, disability
MIGRAINE, MIGRAINE, NEUROLOGICAL DISEASE
Migraine is a common neurological disease affecting 1 billion people worldwide and the leading cause of disability in individuals younger than 50 years of age [Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) are part of the same glucagon/secretin superfamily of structurally related vasoactive peptides and share significant similarities [An investigational humanized monoclonal antibody directed against PACAP, Lu AG09222, is currently being developed for migraine prevention [This proof-of-mechanism randomized controlled trial investigated the effect of Lu AG09222 on vascular responses and headache after PACAP38 and VIP infusion in healthy volunteers. We hypothesized that pre-treatment with Lu AG09222 binds and neutralizes exogenously administered PACAP38 and prevents PACAP38-induced vasodilatory responses and headache, thereby confirming target engagement in this human model [