Introduction
Breast Cancer, T2D, breast cancer, cancer, weight reduction, multiple disease, weight loss
BREAST CANCER, BREAST CANCER, CVD, CANCER, DISEASE
Observational data suggest weight control, physical activity (PA), healthy diet, alcohol and smoking limitation reduce breast cancer (BC) risk in women at increased risk of the disease [The optimal weight loss programmes for women at increased risk are not currently known. In the study reported here we assess remotely delivered weight reduction programmes likely to be preferable to clinic attendees who often live far from the specialist FHRPCs. Remote programmes could also be delivered across a network of FHRPCs from a central centre by health care professionals with appropriate training and skills, thus avoiding the need for local delivery teams, as utilised in the ongoing Breast Cancer Weight Loss (BWEL) trial in the US and Canada [Women in the FHRCP can have increased risk markers for CVD and T2D [This trial aimed to identify whether the remote programmes performed better than written advice to engage women in the FHRPC to lose weight. Also, whether a Breast Cancer Prevention Programme (BCPP) or a multiple disease prevention programme (MDPP) performed best and could be tested in a future definitive trial to identify the clinical and cost effectiveness of the relevant intervention across the UK FHRPC network. The primary outcome of the trial was percentage weight loss at 12 months since long term weight loss is considered most relevant for cancer prevention. Secondary outcomes included the numbers with greater than or equal to 5 and 10% weight loss in the groups, retention to the trial, changes in body composition, health behaviours and fidelity of delivery of the programmes. Process analysis of the trial (both qualitative and quantitive), health economic analyses, and changes in breast density with weight loss will be reported elsewhere.