3.4. Safety
thrombi, respiratory failure, death
ADVERSE EVENTS, RESPIRATORY FAILURE, THROMBI
The recorded adverse events are displayed in Of the four patients in the placebo arm who died, three progressed to respiratory failure: the first developed progressive respiratory failure and expired on Day 7, the second demonstrated initial respiratory status improvement by Day 6 but, following dexamethasone discontinuation, clinically deteriorated and expired on Day 16, and the third rapidly progressed to respiratory failure requiring intubation on Day 3 with ECMO by Day 4 and ultimately expired on Day 27. The fourth death in the placebo arm occurred on Day 2, and the autopsy showed significant pulmonary arteriolar thrombi. 