TLSs are commonly observed in the chronic skin lesions of patients with pemphigus.
pemphigus
SKIN, PEMPHIGUS, INFILTRATING, INFLAMMATORY CELL INFILTRATION, SKIN LESIONS
We retrospectively reviewed H&E-stained slides of skin specimens from patients with pemphigus. Skin specimens with dense inflammatory cell infiltration into the dermis were selected from the slides. To analyze the phenotypes of immune cells infiltrating the dermis, we utilized immunohistochemistry to investigate expression of CD4, CD20, CD138, and peripheral lymph node addressin (PNAd). Tight clusters of CD4Through examination of the clinical characteristics of the patients with TLSs, we found that the duration of skin lesions was at least 4 months (