Setting and design of the study
Down Syndrome
DOWN SYNDROME
The study was a randomized controlled trial with two intervention and control groups. This study was performed on 52 pregnant women with intermediate risk (1: 51 − 1:1500) during first-trimester screening for Down Syndrome and without additional structural anomalies who were selected from urban and rural health centers of Abhar, Khorramdareh and Soltanieh cities located in Zanjan province, Iran, from September 2020 to August 2021.