Enrollment criteria
stroke, impaired liver function, malignant tumors, heart failure, infarction
HEART, STROKE, MALIGNANT TUMORS, HEART FAILURE, IMPAIRED RENAL FUNCTION, INFARCTION
Inclusion criteria were: 1) 18–70 years of age; 2) diagnosed as PA by SIT; 3) no lateralization of aldosterone secretion according to AVS; and 4) serum potassium ≥ 2.8 mmol/L after the run-in period. Exclusion criteria included: 1) impaired renal function [creatinine clearance rate (Ccr) <60 ml/min]; 2) impaired liver function [alanine transaminase (ALT) and aspartate transaminase (AST) >2.5 times upper limit of normal]; 3) patients with heart failure [New York Heart Association (NYHA) ≥class 3 or ejection fraction (EF) <50%]; 4) patients with stroke or acute infarction in the last 6 months; 5) patients who are pregnant or breastfeeding; 6) patients who cannot tolerate the dietary arrangements; and 7) patients with history of malignant tumors in the last 6 months.