Primary endpoint
DFS, death
RECURRENCE, DISEASE, RECURRENCE
The primary endpoint is the difference in DFS at 3 years between the ctDNA-guided arm and the SOC arm. DFS is measured from the time of surgery to recurrence, death from any cause or censored from the last follow up. Recurrence will be based on investigator assessment of clinical or radiological evidence of disease relapse. The analysis population will include all patients treated on the study. The primary population for analysis will be the Intent to Treat (ITT) population, defined as all patients randomised to treatment arms; SOC chemotherapy or ctDNA guided ACT. A sensitivity per protocol analysis will also be performed defined as all those receiving treatment as planned per randomisation.