Conclusion
ventilator-induced lung injury, hypoxia, critically ill, hyperoxia
HYPOXIA, CRITICALLY ILL
FiOClinicaltrials.gov registration number: NCT05807815.Oxygen therapy plays a vital role in the treatment of critically ill patients. Mechanical ventilation (MV) support and therapy are routine practices in intensive care units (ICUs). In critically ill patients treated in ICUs, the focus is on the prevention of hypoxia with a liberal use of oxygen (Recent studies have demonstrated that hyperoxia can be as detrimental as hypoxia, and it directly negatively affects mortality and morbidity (Therefore, avoiding hyperoxia is essential for preventing ventilator-induced lung injury, and it should be considered as part of lung-protective ventilation strategies.Two methods that have been used for oxygen monitoring – pulse oximetry and arterial blood gas analysis - have not been entirely successful in hypoxia detection. Pulse oximetry, which is used noninvasively to help ensure optimal oxygenation, is alone not sufficient to monitor partial pressure of oxygen (PaOTherefore, to achieve optimum oxygenation, noninvasive tools should be used to detect hyperoxia (To achieve optimal oxygenation (neither hypoxia nor hyperoxia), the fraction of inspired oxygen (FiO