4. Discussion
death, neuroinflammation, Cerebral ischemia, brain edema, inflammation, stroke, ischemic stroke, neuronal degeneration, poststroke
HAND INFECTION, CEREBRAL ISCHEMIA, BRAIN EDEMA, INFLAMMATION, STROKE, DYSFUNCTION, ISCHEMIC STROKE
Although intravenous thrombolysis and thrombectomy can be effective in the treatment of ischemic stroke, progressive neuronal degeneration and functional loss remain difficult to resolve during treatment and rehabilitation. Cerebral ischemia promotes the production of proinflammatory mediators and induces cell death and cell dysfunction, thus inducing neuroinflammation. Excessive inflammation can produce neurotoxins and brain edema. Recently, poststroke immune response has recently a new breakthrough goal in the treatment strategy of ischemic stroke [Rehabilitation training can improve the prognosis and daily living of ischemic stroke patients. A nationwide retrospective cohort study in Japan confirmed that early rehabilitation training can improve the daily living of ischemic stroke patients [Some biomarkers have been found correlated to the prognosis of ischemic stroke patients. Kwan et al. found that the increasing of IL-6 was related to the severity and infection of ischemic stroke patients, and serum IL-6 levels could predict the mortality in the first two years after stroke [