Functioning and associated disability
disability
REMISSION
The mean change (SD) from baseline to endpoint in SDS total score of −6.4 (7.14) indicates an improvement in functioning and associated disability during the induction phase. By endpoint of the optimization/maintenance phase, the mean change (SD) was +0.1 (8.23), suggesting maintenance of effect. The percentage of responders (defined as SDS scores ≤4 for each item and ≤12 for the total score) was 44.8% and 54.4% at endpoint of the induction and optimization/maintenance phases, respectively, and percentage of participants in remission (defined as SDS ≤ 2 for each item score and ≤6 for the total score) (Fig. 