Statistical analysis
Characteristics of patients from each group were tested for normality. The normality of data was measured using the Kolmogorov-Smirnov test. The data that had normal distribution were analysed using one-way ANOVA and followed by post hoc analyses. The data that did not distribute normally were analysed using Kruskal-Wallis and Friedmann followed by post hoc analyses. Comparison of the effectiveness of the three drugs was tested using N-Gain analysis. To determine how far the differences exist, Cohen's d effect size analysis was used. Further analysis with Kaplan-Meier survival was conducted. Statistical analysis was performed using
