Maximum change in tumour size (A) and serum PSA (B) from baseline and radiographical progression-free survival (C)
tumour
TUMOUR
Maximal percentage change in tumour size was calculated as the sum of longest diameter of target lesions as per RECIST 1.1 criteria. In part A, one patient with 100% reduction in size of target lesions had non-target lesions present on follow-up imaging and thus was deemed to have partial response. In part C, grey lines show 95% CI lower and upper bounds. PSA=prostate-specific antigen. RECIST=Response Evaluation Criteria in Solid Tumours. *Two patients with no change in size of target lesions compared with baseline.