Statistical analysis
death
REGRESSION
Data are presented as frequency (percentage), mean ± standard deviation, or median and interquartile range, depending on data type and distribution. A detailed statistical analysis plan was prepared and completed prior to database lock. The primary outcome of survival was analyzed by Kaplan–Meier analysis and log rank test. Overall survival was calculated from the date of the end of intervention to the date of death from any cause. Participants remaining alive were censored at the date of last follow-up. Cox regression model was constructed to evaluate the effect of intervention on survival rate. Secondary outcomes were evaluated using Repeated Measure ANOVA and Friedman test. Statistical analyses were performed using IBM SPSS software 25. 