Data availability
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All data used in the present study are available within the manuscript and its Clinical data are available for access upon external requests. Applicants should contact the following email address ‘mariafernanda.mosele@gustaveroussy.fr’ to request access to clinical data. The request will be discussed internally in the joint steering committee of the study. The decision will be communicated within 1 month from the request. Applicants must complete specific documents to be granted a user license.Whole-exome sequencing data generated in this study have been deposited to the European Genome-phenome Archive (EGA) under accession number Databases used in the study include gnomAD (