Statistical analysis
REGRESSION
The intervention vs. control effects on changes in neural targets and self-reported measures of emotional reactivity and cognitive control from baseline to 16 weeks were assessed using The intervention vs. control effects on changes in HADS scores from baseline to 16 weeks were tested using ordinary least square regression with adjustment of baseline values of the outcome measure. Each model included all participants with follow-up data on the outcome at 16 weeks, and participants were analyzed based on the group to which they were assigned. Moderation analysis used the same models as above plus the main effect of each potential effect modifier (e.g., sex) and its interaction with the group; the latter, if significant, rejected the null hypothesis of no moderation. Model-adjusted between-treatment mean differences with 95% confidence intervals (CIs) for the overall sample and the subgroups defined by the effect modifiers were reported. Cohen’s d was calculated by the mean difference between the two groups divided by the pooled standard deviation.Given that this study was a pilot RCT, the primary purpose was to establish a reliable signal regarding the impact of Lumen on neural targets and clinical outcomes that would be promising enough to warrant further research. Towards this end, we used Cohen’s All analyses were conducted using SAS, version 9.4 (SAS Institute Inc., Cary, North Carolina).