Author contributions
G.C.I., E.M.S., G.R., M.L. M. and Y.G. conceptualized and designed the study. G.C.I. and E.M.S. prepared the first draft of the manuscript, provided critical review and revisions of the drafts and approved the decision to submit for publication. F.P., S.A.A. and J.A.P. designed, performed and analysed preclinical experiments using patient-derived xenografts. G.C.I., I.A., J.D.P., B.C., R.S., M.A., M.J.T., M.R.P., D.S.D., S.Shenoy, N.S., H.K. and E.M.S. enroled and treated patients. G.C.I., I.A., J.D.P., B.C., R.S., M.A., M.J.T., M.R.P., D.S.D., S.Shenoy, N.S., S.A.A., F.P., J.A.P., G.R., R.G.B., M.L.M., P.O., Y.G., V.K., S.Smith, G.M.M. and E.M.S. collected data, analysed and interpreted the results and reviewed and edited manuscript drafts. S.Smith participated in conception and design analysis and interpretation of results. M.R.P. and S.A.A. participated in trial conduct and clinical trial discussions. G.M.M. conceptualized and designed the study, analysed data and interpreted results for preclinical studies. V.K. collected data and analysed and interpreted results for pharmacodynamic studies. All authors have read and agreed on the content of the manuscript.