Frequencies of Treg cells are significantly increased after radon spa treatment
RADON EXPOSURE
A clear indicator of systemic immune effects with a potential direct relation to osteoclastogenesis is the ratio of Treg and Th17 cells (Treg cell population was significantly increased and Th17/Treg ratio significantly decreased after radon spa treatment. The fraction of Treg cells (CD4Taken together, we detected a significant impact of radon as well as thermal spa treatment on bone resorption and fraction of mOC. However, the effects were more pronounced after radon exposure for the RANKL concentration and Th17/Treg cells, which were related to the interaction between immune system and bone metabolism. In contrast, adipokines, matrix metalloproteinases, bone formation (OPG, OCN) and bone resorption (CTX) were not affected by radon or thermal spa treatment.