Metformin selectively suppresses expression and activity of the SNAT2 glutamine transporter
We investigated the role of several transporter gene families in metformin's effects on amino acid refeeding. We found that amino acid withdrawal stimulated expression of leucine receptors LAT1-3 (CAT1 belongs to the yGlutamine acts on mTOR at least in part through feedback suppression of SNAT2, which will in turn suppress BCAA uptake because SNAT2 couples ‘uphill’ BCAA accumulation to the plasma membrane sodium gradient [