Participants and screening procedures
Forty eight healthy participants (23 male, age = 32.63 ± 9.90, age range 38) completed repeated study visits in a within-subject study design within 3 weeks (mean 5.67 days between visits, median 3.5, s.d. = 6.16). Inclusion criteria were adults between the ages of 21–65, self-reported drinking at least twice a month, and body weight between 100 and 250 pounds. Participants were administered the CAGE-AID questionnaireOf the 48 included participants, 46 completed three study visits and 2 completed two study visits; however, for technical reasons we lost pre-task brain data for one participant and post-task brain data for another participant. In total, this yielded 282 neural recordings (141 pre-task and 141 post-task) from the original 284 sessions with behavioral data (142 in each pre/post sessions). Participants missing a particular dosing visit, or pre/post brain data are excluded from some paired analyses. We report sample sizes used for each analysis in the corresponding figure legends.The study and all experimental protocols were approved by the independent Institutional Review Board (IRB) at Advarra (#Pro00063785, Columbia, MD, USA). The study also was conducted in accordance with the Declaration of Helsinki. Prior to the participants' first study visit, an informed consent was obtained from all participants. Participants received monetary compensation for their time, effort, and travel expenses. Participants were instructed and reminded not to drink alcohol within 24 h of each study visit or eat 3 h prior to each study visit. Participants were also required to arrange transportation after each study visit for safety. Participants were not drug tested at the time of the study sessions.