Authors' Contributions
WeChat-based, VTE, venous thromboembolism
REGRESSION, EVENTS, HEART, SECONDARY
On behalf of SMART Investigators, Litao Zhang and Yanli Long designed the study and designed the applet (warfarin helper) used in the current study and acquired the fundings. Sha Li and Yanli Long are clinicians from the cardiac surgery, who were responsible for recruiting eligible subjects and managing those complicated cases. Dan Yu, Haiyan Wu, Bing Hua, Li Xie, Xia Yuan, and Yun Li were experienced anticoagulant nurses in our anticoagulant clinic. These ladies managed routine participants and collected data. Zishuo Li and Zhenlu Zhang provided IT support and data analysis. They also were the study supervisor, to review research quality, data security, and privacy protection. LZ and YL drafted the manuscript, which was then revised by the other authors. Litao Zhang and Sha Li contributed equally to this study.The pattern diagram of warfarin management via WeChat-based miniprogram. INR = international normalized ratio.Enrolment and flowchart of the study.Kaplan-Meier analysis of the cumulative incidence of events.Baseline characteristics of the patients.The continuous variables in this table were normally distributed and expressed as mean ± SD. AVR: aortic valve replacement; MVR: mitral valve replacement; DVR: double valve replacement; NYHA: New York Heart Association; VTE: venous thromboembolism; INR: international normalized ratio. The SAMe-TTPrimary and secondary outcomes.TTR: time in therapeutic range; INR: international normalized ratio; HR: hazard ratio; 95% CI: 95% confidential interval.Determinants of high TTR levels (>70%) by logistic regression analysis.INR: international normalized ratio.