Data availability
All of the data needed to recapitulate the analysis found within this study can be found in the manuscript, figures and supplementary information. Source data are provided with this paper. Due to privacy reasons, de-identified data from the study cannot be shared publicly but will be available from the corresponding author (christoph.hoechsmann@tum.de) immediately following the publication of the paper upon reasonable request. The study protocol and statistical analysis plan will also be available. 