Background
Biliary tract cancer, malignant tumours
PROLIFERATION, BILIARY TRACT CANCER, MALIGNANT TUMOURS
Biliary tract cancer (BTC) represents a heterogeneous group of malignant tumours that may arise at any point of the biliary tree [The ABC-02 study established cisplatin and gemcitabine as first-line treatment in patients with advanced biliary tract cancer and represented the standard of care for many years [Trifluridine/tipiracil (Lonsurf(®)) is a novel, orally active, antimetabolite agent comprised of trifluridine, a thymidine-based nucleoside analogue, and tipiracil, a potent thymidine phosphorylase inhibitor. Trifluridine is incorporated into DNA via phosphorylation, ultimately inhibiting cell proliferation. Tipiracil increases systemic exposure of trifluridine when coadministered [