Ethics approval and consent to participate
This study was approved by the Ethics Committee of the Affiliated Hospital of Binzhou Medical University, No. (2021KT-014). All the legal guardians of the children voluntarily signed the informed consent.All methods in our study were performed in accordance with the relevant guidelines and regulations. Ourstudy was registered in the Chinese Clinical Trial Registry on November 6, 2021, with the registration number ChiCTR2100052830.