Doxycycline and trace fear acquisition
LME
Next, we investigated drug differences in a preregistered LME model for SCR and PSR. For SCR, we found higher CS+ than CS− responses at all time points (main effect CS), larger SCR to CS presentation in the doxycycline group (main effect group), and faster SCR habituation in the placebo group (group × trial interaction), to CS presentation and during the trace interval (see LME analysis of SCR and PSR during trace fear acquisitionModels are estimated with lme4, lmer(data ∼ (1|subject) + group*condition*trial), significant (In an exploratory analysis, we tested for sex differences and found that both men and women differentiate CS+/CS− successfully, both in the placebo and doxycycline group (see Extended Data Acquisition paired t test CS+/CS− per gender, not corrected for multiple comparisons. Download Acquisition independent t test between CS+/CS− difference for placebo and doxycycline group per gender, not corrected for multiple comparisons. P = Placebo, D = Doxycycline Download 