Eligibility criteria {10}
hypersensitivity
DISEASE, HYPERSENSITIVITY
Inclusion criteria:For human treatment/safety cohortResidents of the study areaMale or female weighing more than 15kgAdult able to provide written consentMinors aged 12 to 17 able to provide assentParent/guardian’s ability to provide consent for minorsNegative pregnancy test for women aged between 13 and 49Agreement to adhere to study visits and proceduresFor pediatric active cohort:Children in the age of highest burden at the time of enrollment (under 5 years of age)Residents of the study areaParent/guardian’s ability to provide consent for minorsFor cross sectionalsResidents of the area for at least 3 months prior to enrolmentParent/guardian’s consent for minorsAbility to provide assent for minors aged 12 to 17Written consent from adultsFor livestock treatment:Owner/guardian able to provide consentAnimal expected to spend at least one week every study month inside the cluster borderExclusion criteria:For human treatment/safety cohort:Known hypersensitivity to ivermectin or albendazoleRisk of Loa as assessed by travel history to Angola, Cameroon, Chad, Central African Republic, Congo, DR Congo, Equatorial Guinea, Ethiopia, Gabon, Nigeria, or SudanPregnant womenLactating women in the first week postpartumChildren < 15 kgCurrently participating in another clinical trialUnwilling to provide informed consent or assentUnwilling to adhere to study visits and/or proceduresSeverely ill either self-reported or in the eyes of the investigator, e.g., defined as the need for clinical care, or active or progressive disease interfering with activities of daily living. If in doubt, these criteria can be confirmed after a call with either the site PI/MD/safety officer against a pre-defined list.Currently under treatment with inhibitors of CYP3A or P-gp or other drugs that can interfere with the studyFor active pediatric cohort:Non-residentsCurrently enrolled in other clinical trialsFor cross sectionalsNon-residentsFor livestock treatmentReceived ivermectin less than 4 weeks agoIntention to milk or slaughter the animal for human consumption during the withdrawal periodCalves under 8 weeks and piglets under 6 weeks of age.