Ethics approval and consent to participate
Study approval was obtained from the Institutional Review Board of Ethics Committee of Affiliated Hospital of Nantong University (registration number 2022-K023) on 20/04/2022 and the PODCAST trial is registered with clinicaltrials.gov, number NCT05533970 on 09/09/2022. Patients and their family members informed the treatment and signed a consent form. The trial was conducted in accordance with the Declaration of Helsinki.