Author contributions
RA
Preclinical: ARO, KBG, RA Mangieri, RA Morrisett, AJR, and MFL conceived and performed the preclinical experiments, performed analyses, and wrote the manuscript. EJF, AT, KGT, and HCA performed the preclinical experiments. PM analyzed preclinical data. JCC, MR, and HCB conceived the preclinical experiments and edited the manuscript. Clinical: BJM conceived and conducted the clinical study, interpreted results, and wrote the manuscript. JML analyzed the clinical data, interpreted results, and wrote the manuscript. AB, JB, JM, SQ, FS, and MS conducted the clinical study. TKE and JJM analyzed the physiological data and interpreted results.