Discussion
infection, CMV infection
INFECTION, HAND INFECTION, CMV INFECTION, BLIND
In previous studies, the rates of HM-acquired CMV infection had a wide range from 10 to 40%, and the rate of symptomatic CMV infection also had a wide range from 1 to 10% [Two out of seven (28.6%) children with CMV infection showed CMV-associated symptoms. Symptomatic CMV infection is more common in premature infants because of their immature immune system and relative lack of maternal IgG [Numerous efforts have been made to reduce the risk of HM-acquired CMV infection by pre-treating HM [Since the CMV positivity rate in women of childbearing age varies greatly from country to country [Studies have shown that reactivated CMV begins to be secreted through HM within a few days after birth, even in colostrum, and its load gradually increases, peaking between 3 and 6 weeks after birth and then gradually decreasing over 2–3 months during lactation [This study has some limitations. A correlation between CMV DNA load and infection or a statistically significant difference in infection rate according to sterilization method could not be confirmed, which is thought to be due to the small number of patients. Since the CMV infection rate is low, only 7 infants were infected. Moreover, CMV DNA titer values could not be measured in all patients or at all time points. Also, CMV DNA dose not fully refect the CMV infectivity. And several important factors including protective antiodies or immue status could not be considered. However, this study is the first randomized controlled double blind trial to investigate the association between postnatal HM-acquired CMV infection and pasteurization in premature infants.