Background
neuromuscular block, bradycardia, vomiting, nausea
ADVERSE EVENTS
Application of muscle relaxants can improve the surgery and anesthetic conditions of patients undergoing general anesthesia, and they are commonly used in the clinic [Neostigmine, which is the most commonly used antagonist of muscle relaxants in the clinic, is often used at a dose of 0.02–0.07 mg/kg. Common adverse events include bradycardia, nausea, and vomiting [Therefore, we hypothesized that recovery of spontaneous breathing could be used as a substitute of neuromuscular monitoring to guide the use of neostigmine to reverse the neuromuscular block. We aimed to evaluate the incidence of rNMB in pediatric patients with routine use of neostigmine after recovery of spontaneous breathing compared with the patients with the use of neostigmine guided by neuromuscular monitoring in this randomized, controlled noninferiority trial.