Impact on Exploratory CSF Biomarkers
CSF was collected at baseline and end of study (24 weeks) as an exploratory outcome for treatment response in 16 patients. A proteomics platform was used to assess the effect of liothyronine treatment on the CSF proteome in MS.Of the measured proteins, 46 changed (19 increased and 27 decreased) over the course of the study (Enrichment analyses revealed over-represented angiogenesis and innate and adaptive immune functionTop proteins altered by liothyronine treatment