Conclusion
cancer, volume reduction, breast cancer
CANCER, BREAST CANCER
A moderate-to-high intensity 6-month exercise intervention did not change total hippocampal volume, hippocampal subfield volumes, cortical thickness and voxel-based grey matter volumes in patients with affected cognition after breast cancer treatment. However, results suggested that physical exercise leads to hippocampal volume reduction in highly fatigued breast cancer patients, which was related to better memory functioning. Future research should target highly fatigued cancer patients and focus on the relation between hippocampal volume change and memory improvement.