Correlative studies
serous
Correlative analyses were performed on archival tissue. Forty-six patients had sufficient tissue available and were included in the immunohistochemistry analysis (24/25 from C1 and all from C2), and forty-three in the molecular analysis (21/25 from C1 and all from C2; Fig. An overview of the immunohistochemistry and genomic findings per cohort and histology are listed in supplementary table PTEN loss by IHC was present in 32% and 50% of samples in C1 and C2, respectively. Based on the molecular profiling results, 33.3% (9.5% serous and 24% endometrioid) of C1, whereas 41% (35.5% endometrioid and 4.5% mixed serous and endometrioid) of cases of C2 harboured Abnormal p53 by IHC was seen in 56% and 55% of patients in C1 and C2, respectively. Alterations in Oncogenic alterations in homologous recombination repair (HRR) genes were seen in 38% and 45.4% of patients in C1 and C2, respectively, with 