Conclusions
In summary, the present study demonstrates the potential benefits of lifestyle interventions when a combined physical and cognitive intervention protocol is adopted. For the AE group, we reported an increased rsFC that involved mainly the aDMN, pDMN, and also FPN, VAN, and VN and a decreased rsFC that involved the pDMN, the hippocampus, and the left and right supplementary motor areas, as well as the right thalamus. For the CCT group, we found a combination of increased and decreased rsFC between brain areas located mainly in the aDMN and pDMN. The greatest alterations of rsFC were revealed in the COMB group. These findings involved a decreased rsFC within the aDMN and within the pDMN, an increased rsFC between the aDMN and pDMN, and a reduced rsFC between the left and right supplementary motor areas and the right thalamus as it was found in the AE group.