Intervention
®, fatigue
All groups received the intervention between January 2022 and April 2023. Both the EG and the CG received two 60-min sessions per week over an eight-week period (a total of 16 sessions per group).The CG received a specific conventional physical therapy intervention by a physical therapist expert in MS patient care. This intervention was based on conventional physical therapy exercises [The EG received the same conventional physical therapy treatment (45 min) in addition to a semi-immersive VR intervention using the MYO Armband® sensor (15 min) and specifically designed video games for this protocol. The intervention was implemented by an expert therapist proficient in the use of the technology. The patient's starting position was seated in front of a table at mid-trunk height, with the elbow at 90° of flexion and the forearm in a neutral pronation-supination. Manual assistance was provided by the therapist when necessary.In each video game session, prior to using the device, gesture calibration was performed to improve sampling accuracy and individualise the treatment for each participant. The calibration process included training the system's gesture classifier to optimize the device's performance and minimise the effects resulting from the placement of the armband. It should be noted that the armband is manually placed at an approximate distance of 3 cm from the patient's elbow. However, since it is a manual placement process, an exact location in the same spot on the arm cannot be guaranteed. Finally, each session focused on a different UL to facilitate the distributed practice principle, aiming to prevent early fatigue. The first day of intervention started with the less affected hand.