2.1. Study Design
obesity
OBESITY
We conducted a three-week dose-escalating clinical trial at the Pennington Biomedical Research Center, in Baton Rouge, Louisiana. We tested the safety and tolerability of WGS incorporated into food products in older adults with obesity in preparation for an intervention trial that is ongoing in this population. The doses were determined on the basis of the dietary fiber in WGS, as there are recommendations for the consumption of dietary fiber. WGS contained approximately 36% dietary fiber. Relatively large doses of dietary fiber are tolerated if the daily intake is gradually increased and divided into small portions throughout the day [