Study design ethics, and patient population
PONV, hypersensitivity, abnormal liver or renal function
MOTION SICKNESS, HYPERSENSITIVITY
This study was a double-blinded, randomized clinical trial that was carried out in the oral and maxillofacial surgery department of Imam Hossein Hospital (Tehran-Iran). This study was approved by the Research Ethics Committees of the research institute of Dental sciences-Shahid Beheshti University of medical sciences and registered at the Iranian Registry of Clinical Trials (IRCT code: IRCT20211205053279N3) and conducted following the Declaration of Helsinki. All patients provided written informed consent to participate in the study.All patients between the ages of 15-50 years with an American Society of Anesthesiologists (ASA) physical status of I–II scheduled to undergo orthognathic surgery under general anesthesia were enrolled in this study between April 31, 2022, and March 8, 2023. Exclusion criteria were as follows: abnormal liver or renal function, patients with known hypersensitivity to ondansetron or aprepitant, and pregnant or nursing mothers. Patient information, including gender, history of PONV and motion sickness, and smoking status was recorded. Computer-generated random numbers divided the patients into two groups. Randomization was forwarded directly to a nurse who was not involved with the patients’ management and assessment.