Hamilton depression rating scale (HDRS)
TSD
At baseline (day-1), the HDRS17 total score (mean [SD] was 20.0 [4.03] for group A (JNJ-54175446 early start); 18.1 [4.38] for group B (JNJ-54175446 late start); and 18.9 [4.04] for group C (placebo), respectively.Effects of TSD per average HDRS17 total score [SD], measured as change from baseline (day -1) on day 4, were −2.3 (3.82) in group C (placebo), somewhat larger (−3.9 (2.97)) in group A, and slightly smaller (−1.5 (3.33)) in group B. Although on day 4 a numerically larger proportion of patients demonstrated a ≥ 25% improvement on the HDRS17 total score in group A [9/25 (36%)] compared with group C [5/27 (29%)] or group B [5/25 (20%)], these differences were not significant (No significant differences (mean change [SD]) on day 10 compared with baseline were observed in any treatment group versus placebo: Group A −4.8 [4.69] 