MSC dose comparisons in RCTs
The studies included in RCT analyses used a range of doses from 3.9 × 10Differential median baseline WOMAC total scores for the 10 × 10Lamo-Espinosa et al. conducted a subsequent 4-year follow-up study with 27 of the 30 patients [Similarly, Chen and Hu et al. demonstrated improvements in overall WOMAC scores at 48 weeks posttreatment in the group receiving the highest dose (64 × 10Conversely, two studies, Gupta et al. [Kuah et al. [Taken together, the limited RCT data on dose escalations provide no evidence of a clear winner in terms of patient-reported outcomes. While both the Gupta et al. [