Conclusions
In this RCT, all study participants showed significant improvements with respect to subjective and objective outcomes related to GSM at 6 months’ follow-up, regardless of whether or not they received laser therapy, suggesting that vaginal laser treatment was not effective. Therefore, although vaginal laser treatment was safe, causing often only mild AEs, its efficacy remains to be demonstrated. Further RCTs with a longer follow-up and meta-analysis are needed to confirm the results of this RCT.