Safety assessments
ADVERSE EVENT
The safety and tolerability were defined by the incidence of AEs and severe AEs. The grading of AEs was assessed by investigators according to the Common Adverse Event Evaluation Criteria, v5.0. The irAEs were mainly managed according to local medical practice. The investigator comprehensively evaluated the benefit/risk ratio of the subject and made a judgment on stopping/resuming dosing according to the management of the irAEs guideline [