3.6. Mutation Profiling
NF1
In the oncoplot of the analysis of C0 samples, a TP53 mutation was the most common variant (66%), and five of the six patients who had rapid progression in the NDB group had a TP53 mutation. KRAS, NF1, PIK3CA, JAK2, NFE2L2, and RB1 mutations were more frequently detected in the DCB group, and CDKN2A, ARID1A, and EGFR mutations were more common in the NDB group; however, the differences were not statistically significant (In the sunburst charts of the analysis of C0 and matched C4/EOT samples, 74 and 269 variants were detected in the DCB and NDB groups, respectively. The proportions of variants only detected at C0 were significantly higher in the DCB group (40.5%) than in the NDB group (7.4%). The proportions of variants only detected at C4/EOT were higher in the NDB group (16.7%) than in DCB group (2.7%) (