Methods – design
tumor
TUMOR
We propose to carry out an observational non-randomized prospective clinical trial on patients diagnosed with an early SSCC where 3 subgroups are studied in parallel:Arm 1: Radiotherapy ± chemotherapy (RCT)Arm 2: Trans-oral Laser Microsurgery (TLM)Arm 3: Trans-Oral Robotic Surgery (TORS)The inclusion will be multicentric and international. The treatment will be chosen by the local multidisciplinary tumor board (MTB) according to the primary cTNM-stage, the patient preferences and the local standard of care based on peer-reviewed international guidelines (Fig. SPIRIT Flow DiagramTrial Design