Immunomodulatory effects differ by clinical response
ONCOLOGY
Serial peripheral blood mononuclear cells obtained from patients were assessed by mass cytometry. (A) A UMAP plot of cell populations assessed from whole blood samples obtained from the full cohort. (B) Statistical scaffolding of the relationships between cell clusters identified in samples obtained from patients with a response and those who had no response to treatment. (C) Heatmaps summarising logBaseline characteristicsData are median (IQR), or n (%). RECIST=Response Evaluation Criteria in Solid Tumours. ECOG=Eastern Cooperative Oncology Group. PSA=prostate-specific antigen. *One patient had a Treatment-emergent adverse eventsData are n (%).