Conflict of interest
LDL is a consultant to G1 Therapeutics and 7 Hills Pharma LLC. He also received, through an award to his institution, clinical trial funding for this study from AstraZeneca and other similar clinical trial funding support from the following sponsors: Bristol Myers Squibb, Bayer Pharmaceuticals, and AbbVie. WJE is a consultant for Chimerix Corp. MA and MN are employees and shareholders of AstraZeneca. LHO was an employee of AstraZeneca when this study was designed, executed, and reported. LHO is also a shareholder of AstraZeneca. All other authors have declared no conflicts of interest.