Outcomes
PD, death, SD
DISEASE, DISEASE PROGRESSION, SECONDARY, TUMOR PROGRESSION
The primary endpoint was ORR, defined as the proportion of patients with complete response (CR) and partial response (PR). The secondary endpoints comprised the disease control rate (DCR, defined as the proportion of patients with CR, PR, and stable disease [SD]), duration of response (DoR), PFS, OS, and safety. DoR was defined as the time from the first CR or PR to progressive disease (PD). PFS was defined as the duration from the date of enrollment to the date of any recorded tumor progression or death from any cause, while OS was the duration from the date of enrollment to death from any cause. Patients with neither disease progression nor death were censored at the date of the last follow-up.