Discussion
VIRUS
Although the use of mouthwashes has been discussed as a potential measure to reduce
transmission of SARS-CoV-2 since the beginning of the COVID-19 pandemic, the clinical
evidence is still limited, particularly as there are only very few studies assessing their
effects on viral infectivity by virus rescue in cell culture (CHX and CPC can be considered gold-standard antiseptics in dentistry and have a broad range
of application in mouthwashes or other oral care products (According to available results from in vitro studies, CPC has shown promising antiviral
effects against SARS-CoV-2 (When assessing the effects of the mouthwash on viral loads, we found slight reductions in
both groups. Despite statistical significance found for the 0.8 logThe successful rescue of SARS-CoV-2 in cell culture is very challenging and strongly
correlates with high viral load in the samples (>10Besides the main scope of the present study, we also assessed the viral load and viral
infectivity of the baseline oropharyngeal specimens with respect to the COVID-19 vaccination
status of the included patients. Interestingly, we found that the samples from individuals
with 3 vaccine shots exhibited significantly less infectious particles than those with just
2 vaccine shots. IgA and IgG neutralizing antibodies (nAbs) have been detected in the saliva
of patients vaccinated with 2 shots of messenger RNA–based vaccines (