INTRODUCTION
macrovascular and microvascular function
SECONDARY
The average sodium intake in the United States is ~3500 mg/day while the Dietary Reference Intakes recommend ≤2300 mg/day (Stallings et al., Melatonin is a hormone synthesized in the pineal gland predominantly at night and has been shown to have antioxidant properties (Tengattini et al., Therefore, the primary aim of this study was to determine the effect of melatonin supplementation during 10 days of a HSD on macrovascular and microvascular function. Our secondary aim was to determine the effect of melatonin during 10 days of a HSD on ROS levels. We hypothesized that melatonin supplementation during 10 days of a HSD would lead to greater vascular function and lower ROS compared to a HSD plus placebo.