4.4. Salivary Concentrations of Polyamines
teeth [
To our knowledge, no data on the salivary pharmacokinetics of spermidine, spermine, and putrescine after oral supplementation of spermidine have been published before. In our study, neither the salivary AUCPolyamines, including spermidine and putrescine, reportedly have diverse functions in the bacterial physiology of the oral microbiota [As described earlier, a reduction of the viral replication of SARS-CoV-2 by 85% was demonstrated in vitro at a concentration of 333 µM spermidine, encouraging discussions about the preventive or even therapeutic potential of spermidine in the context of COVID-19 [Furthermore, limited data are available on salivary concentrations of spermidine, spermine, and putrescine without oral spermidine supplementation. Cooke et al. investigated the time profiles of putrescine, cadaverine, indole, and skatole upon waking and during the day [Li et al. measured the salivary concentration of various polyamines and amino acids in five healthy volunteers before and after they brushed their teeth [