Statistics
HER2-negative tumors, tumors, tumor
REGRESSION, TUMOR, TUMORS
Values are reported as the mean ± SD. Differences between uptakes in organs at different injected masses of the protein were analyzed using one-way analysis of variance (ANOVA). The nonparametric Mann-Whitney U test was used to determine whether the differences between uptake for HER2-positive and HER2-low or HER2-negative tumors were significant. A 2-sided P value of less than 0.05 was considered significant. Paired t tests were used to analyze differences between uptake in organs at different time points. A linear regression analysis was performed to determine if there was a correlation (the slope was significantly nonzero) between the HER2 expression level determined by IHC/FISH and tumor uptake. The sensitivity and specificity of discrimination between HER2-positive tumors and tumors with low expression or HER2-negative tumors using imaging after injection of 1000 µg 