Molecular Analysis
RNA from FFPE (miRNeasy RNA FFPE Kit, Qiagen) and snap-frozen tissues (miRNeasy RNA mini Kit, Qiagen) was extracted per standard manufacturer protocols. Concentration and purity were measured using NanoDrop One Spectrophotometer (Thermo Fisher Scientific) and Qubit 3.0 Fluorometer (Life Technologies). For whole transcriptome library construction, 500 ng of total RNA for each sample was used. See Supplementary Data 2 for detailed methods.