Coronary physiology assessment
hyperemia, infarct
HYPEREMIA, INFARCT
All coronary physiology measurements were performed 3 months after the STEMI by an experienced interventionalist who was blinded to the revascularization technique employed during primary PCI. CFR, fractional flow reserve (FFR), and IMR were assessed using the CoroFlow system (Coroventis Research AB, Uppsala, Sweden). After undergoing successful staged PCI, nitroglycerin was administered through the guiding catheter, and a coronary pressure/temperature sensor-tipped guidewire (Pressure Wire X; Abbott Vascular, Santa Clara, CA, United States) was equalized to the guide catheter pressure with the pressure sensor positioned at the tip of the catheter at the aortic sinus, then advanced to the distal two-thirds of the infarct related artery. Maximal hyperemia was induced by repeated intracoronary adenosine boluses. After achieving maximal hyperemia, three milliliters of normal saline were administered through the guiding catheter and IMR was calculated. If the measurements obtained from the first three administrations were inconsistent, the measurements were repeated to ensure accuracy CFR was determined as the difference between the baseline and hyperemic mean transit time (T