Evaluation of the OS predicting nomogram
ALL, breast cancer
BONE METASTASIS, BREAST CANCER
As shown in Receiver operating characteristic (ROC) curves of 1, 3, and 5-year in the training (A) and validation cohorts (B), respectively. The area under the ROC curve (AUC) was 0.797, 0.782, and 0.794 in the training cohort, and 0.723, 0.742, and 0.704 in the validation cohort, respectively.In both training and validation cohorts, the calibration curves were generated to suggest that the nomogram-predicted OS had good accordance with the actual OS (The calibration curves of the prognostic nomogram for the 1, 3, and 5-year OS prediction of the training (A–C) and validation group (D–F). the calibration curves suggested that the predictive outcome have good accordance with the actual 1, 3, and 5-year OS in both training and validation group.DCA of the nomogram for the survival prediction of breast cancer patients with bone metastasis in the training and validation groups. (A–C) 1, 3, and 5-year survival benefit in training cohort; (D-F) 1, 3, and 5-year survival benefit in validation cohort. The ‘ALL’, ‘none’ and ‘nomogram’ lines are represented as ‘intervention for all’ (blue dashed line), ‘intervention for none’ (green dashed line), and ‘result for the nomogram’ (red line). the ‘none’ and ‘ALL’ lines would show the expected net benefit without and with the intervention development respectively. DCA curves showed that nomogram manifested a higher net clinical benefit than ‘none’ and ‘all’.After that, we obtained the normalized prognostic scores derived from the Cox model and grouped patients into low-risk and high-risk groups based on the median value of these scores. Specifically, patients with a normalized prognostic score less than or equal 1.93 were classified as low-risk, while those with a score greater than to 1.93 were classified as high-risk. Kaplan-Meier survival analysis and log-rank tests were then used to compare the overall survival (OS) between these two groups. Our findings revealed that patients in the high-risk group had a significantly shorter OS compared to those in the low-risk group (Kaplan-Meier curve of risk stratification for OS based on nomogram. The low-risk and high-risk meant normalized prognostic scores ≤ 1.93 and >1.93 for OS, respectively. Log-rank test was applied to estimate the significant difference.