Material and methods
This was a pilot study conducted in full accordance with the ethical principles of Declaration of Helsinki, revised in 2013 and Good Clinical Practice (GCP) Guidelines. The study protocol was independently reviewed and approved by the National Health Service (NHS) Solihull Research Ethics Committee (Reference number 21/WM/0068; IRAS Number 289334; initial approval 20/04/2021) and registered in a clinical trial registry (ClinicalTrial.gov NCT04723446; 25/01/2021). The study followed the CONSORT checklist for reporting a pilot study (S1 Table).