Background
Alzheimer, memory complaint, MAPT
ALZHEIMER
The MAPT (Multidomain Alzheimer Prevention Trial) study has tested cognitive effect of omega 3 polyunsaturated fatty acid supplementation (omega 3) and multidomain intervention (MI) in non-demented subjects with memory complaint [In a subgroup of the MAPT study, amyloid blood assays have been performed from the MAPT biobank to determinate amyloid status of the participants. These data are an opportunity to validate encouraging findings from MAPT-AV45 and to assess the possibility of such preventive trials based on blood biomarkers in the future. Moreover, two additional years of clinical observation were performed after completion of the MAPT interventional program to track durability of the intervention once discontinued. Therefore, we evaluated the long-term cognitive effect over a 36-month treatment period and at 60 months, 24 months after discontinuation of non-pharmacological intervention in the subgroup characterized by blood biomarkers.