Endpoints and definitions
death
SECONDARY
The primary endpoint of SYNTAXES study was all-cause death at 10 years. RR was collected within the first 5 years, but no longer recorded after 5 years in SYNTAXES study. The present study is a secondary analysis from the SYNTAXES study assessing the association between RR procedures within 5 years and 10-year all-cause death. In case of patients undergoing more than one RR (regardless of the type), the time-to-first-event was considered for statistical analysis.The association between the type of RR (PCI or CABG) and 10-year all-cause death was also explored. Patients undergoing RR were categorized into three subgroups according to the type of additional intervention: RR-PCI (patients underwent ≥ 1 RR only by means of PCI), RR-CABG (patients underwent ≥ 1 RR only by means of CABG), and RR-PCI/CABG (patients underwent ≥ 2 RR by means of both PCI and CABG).Initial PCI and initial CABG refer to the primary revascularization procedure driven by randomization. A staged revascularization procedure was permitted in the SYNTAX trial protocol, provided it was performed ≤ 72 h of the index procedure and during the same hospital stay [