Author Contributions
P.D., P.L., I.W., P.W., R.W. and D.S. designed the study. P.D. and D.S. conducted the study and collected the data. P.D. wrote the manuscript. P.W., I.W., M.d.L.-D., R.W., A.P.H. and P.L. provided the conceptual and technical guidance to the study design and manuscript. S.D. and A.V.K. contributed to design of the DLW study, and subsequent analysis of TEE. Data were analyzed and interpreted by P.D. and R.W. provided statistical input for analysis and interpretation. All authors have read and agreed to the published version of the manuscript.