Aims
SECONDARY
The primary endpoint was the change observed in glucose disposal (Gd) from pre-treatment measurement to post-treatment assessment, as measured during a hyperinsulinaemic clamp. Pre-defined secondary endpoints included changes in EGP, lipolysis (systemic and adipose tissue), 24 h BP measurements, circulating lipid profiles, osteocalcin, urinary steroid metabolites, gene expression profiles and immunoinflammatory response as measured by the OX40 assay.