Findings
In this cohort study of 16 523 community-dwelling healthy participants, 1256 died over a mean (SD) of 4.4 (1.7) years of follow-up. Among men, loss of 5% to 10% of body weight and loss of more than 10% of body weight were associated with a 33% and 289% increase in mortality, respectively; among women, loss of 5% to 10% of body weight and loss of more than 10% of body weight were associated with a 26% and 114% increase in mortality, respectively.