Abbreviations:
NCT04808544.Informed
area under the curvechronic postsurgical painmultimodal analgesianon-steroidal anti-inflammatory drugsquality of lifesebacoyl dinalbuphine ester12-item short formvisual analog scaleC-FL and J-LC contributed equally to this work.This study was supported by the Ministry of Science and Technology of Taiwan (grant no. MOST 109-2314-B-650-007-MY2 to Chen-Fuh Lam) and institutional grants from the E-Da Hospital, Taiwan (EDAHP111003 and EDPJ110069 to Chen-Fuh Lam).This study was approved by the institutional review board of the E-Da Hospital, Kaohsiung, Taiwan (approval number EMRP28110N). The trial was registered in March 2021 with Clinicaltrials.gov registration: NCT04808544.Informed written consent was obtained from all the participants before the commencement of the study. All procedures in this study were conducted in accordance with the institutional ethical standards and with the 1964 Helsinki declaration and its later amendments.This was a PI-initiated clinical research project, and the authors have no conflicts of interest to disclose.The datasets generated during and/or analyzed during the current study are not publicly available, but are available from the corresponding author on reasonable request.How to cite this article: Lee Y-E, Fu C-Y, Shiue Y-L, Lu C-Y, Chen C-Y, Chen J-H, Chen J-L, Lam C-F. Efficacy and safety of an extended-release sebacoyl dinalbuphine ester for laparoscopic cholecystectomy: A randomized controlled trial. Medicine 2023;102:31(e34423).