Statistical analysis
REGRESSION, SECONDARY
Statistical analyses will be performed with SPSS (version 21). Subjects will be analyzed in the group to which they are randomized, regardless of the treatment received. A T test will be used to compare the mean CIMT changes of virally supressed HIV patients with CMV seropositivity in the atorvastatin group versus the placebo group between the baseline and week 48 to analyze primary endpoints. Meanwhile, secondary endpoints will be analyzed using linear regression with interaction to assess the magnitude of change in the effect of atorvastatin on CIMT associated with the baseline CMV copy number, and a proportional odds logistic regression model will be used to estimate the odds ratios of CPI in treating an increased level of CIMT. Other continuous endpoints will be analyzed using a 2 sample T-test. Missing data will be resolved by comparing subject characteristics in the drop out group with the remaining participants. If there is no difference in characteristics it would assumed that the missing data is at random.
