Acknowledgements
This work was supported by grants from the National Natural Science Foundation of China (Grant number 82003161), Program of Shanghai Sailing Project from the Science and Technology Commission of Shanghai Municipality (20YF1459600), Clinical Research Plan of Shanghai Hospital Development Center (SHDC12019X04) and Mengchao Talent training plan. We are grateful for the help of Dr. Mingzhe Xiao, Si Li, Ran Ding, Chao Zhang, who are all from Jiangsu Simcere Diagnostics Co., Ltd, the State KeyLaboratory of Translational Medicine and Innovative Drug Development, Nanjing, China.