Discussion
diabetic mothers might, retinal damage, constipation, dehydration, skin rash, nausea, vomiting
DEHYDRATION, HYPOCALCEMIA, RETINAL DAMAGE
Phototherapy is a cheap, simple, non-invasive method with appropriate effectiveness. This treatment has side effects such as changes in circadian rhythm, dehydration, hypocalcemia, skin rash, and retinal damage [In the present study, we compared TSB at the beginning of hospitalization and at the time of discharge between two groups. TSB at discharge was significantly reduced in the UDCA group. Although TSB at admission in both groups was about 17.1 mg / dl, but at discharge, it was significantly lower in the intervention rather than the control group. In the previous studies, bilirubin levels have been measured at regular intervals with the same interventions. Although Jafari et al. who compared groups at 8, 12, 24, 36, and 48 hours of hospitalization showed decreased bilirubin level in both groups, the difference was statistically significant only at 8 [Based on the findings of our study, the mean duration of hospitalization in the UDCA group was significantly lower than the control group. Consistent with our results, previous studies mentioned a significant difference between mean duration of phototherapy between two groups as well [Gharehbaghi et al. also revealed that the length of hospital stay was reduced and more than 70% of infants receiving the dose of 7.5 mg / kg of UDCA were hospitalized for less than one day, but in the group receiving the dose of 5 mg / kg and the control group, 42.5% and 17.5% of infants were hospitalized less than one day [Also lack of any possible side effects including nausea, vomiting, constipation, and skin rash in the intervention group suggested an acceptable and safe profile of the drug. Consistent with these results, several human and animal studies have confirmed the safety and efficacy of UDCA in both adults and children [We have one main limitation that should be considered in further studies. It would be better if we could compare term neonates with preterm ones. Besides, comparing term neonates with and without risk factors such as ABO & Rh incompatibilities, G6PDd, and infants of diabetic mothers might be considerably informative.