Eligibility criteria
neurologic or psychiatric disorders, cancer, liver cirrhosis, hepatitis, esophageal infiltration, gastric adenocarcinoma
CARDIOVASCULAR DISEASE, DRUG HYPERSENSITIVITY, CANCER, LIVER CIRRHOSIS, GASTRIC CANCER, ONCOLOGY, HEPATITIS, GASTRIC ADENOCARCINOMA
All patients had histologically confirmed untreated gastric adenocarcinoma based on an endoscopic biopsy of the primary lesion. The major inclusion criteria were diagnoses of cT3–4, N1–3, and M0 (according to the Japanese Gastric Cancer Classification: 3rd English edition) based on image findings (endoscopy, abdominal CT), and laparoscopically proven H0, P0, CY0. In addition, patients who were capable of oral intake were Eastern Cooperative Oncology Group performance status (ECOG-PS) ≤ 1 and over 70 years of age. Exclusion criteria included an esophageal infiltration distance of 3 cm or more, presence of liver cirrhosis or active hepatitis, history of neurologic or psychiatric disorders, cardiovascular disease, drug hypersensitivity, or another cancer diagnosis within the past five years. Detailed inclusion and exclusion criteria are listed in Online Resource 1.