Tacrolimus dosing in the active group
TTV
If TTV is not within the optimal range, the TAC trough level target has to be adapted by one step up or down compared to the current TAC trough level. If TTV is below the optimal TTV range, the TAC trough level target has to be increased by one step compared to the current TAC trough level, and if TTV is above the optimal TTV range, the TAC trough level target has to be decreased by one step compared to the current TAC trough level. One TAC trough level adaption step is defined as 2 ng/mL (investigators are allowed to target a range of ±1 ng/mL; thus one step might be within a minimum of 1 ng/mL and a maximum of 3 ng/mL).