Eligibility criteria
amenorrhea
The patient inclusion and exclusion criteria are detailed in Table Eligibility criteriaPeripheral hemogram and liver and kidney function should achieve the following permissible limits (tested within 7 days prior to treatment initiation):White blood cells (WBC) ≥ 3.0 × 109/L or neutrophils (ANC) ≥ 1.5 × 109/L;(a) Hemoglobin (HGB) ≥ 80 g/L;(b) Platelets (PLT) ≥ 80 × 109/L;(c) Hepatic transaminases (AST, ALT) < 2.5 times the high limit of the normal range.;(d) Total bilirubin (TBIL) < 2 times the high limit of the normal range;(e) Creatinine (CREAT) < 1.5 times the high limit of the normal range.Women of childbearing age should take appropriate contraceptive measures from the beginning of screening to 3 months after stopping the treatment and should not breastfeed. No risk of pregnancy should be proved by a negative pregnancy test (urine or serum) within 7 days before the start of administration, or one of the following criteria  a. Postmenopausal, defined as age ≥ 50, and amenorrhea for at least 12 months after cessation of all exogenous hormone replacement therapy.  b. Postmenopausal age ≤ 50, and amenorrheic for 12 months or more after discontinuation of all exogenous hormone therapy, and luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels are within reference values for postmenopause.  c. Previous irreversible sterilization, including hysterectomy, bilateral oophorectomy or bilateral salpingo-oophorectomy, not including bilateral tubal ligation.1. Have received any of the following treatments:  a. Prior treatment with any PARP inhibitor or anti-angiogenic drug including anlotinib, avastin, sorafenib and thalidomide, etc.  b. Have undergone major surgery within 4 weeks prior to the first dose.  c. Have received more than 30% bone marrow irradiation or has received extensive radiotherapy within 4 weeks prior to the first dose.Other reasons that the trial treatment cannot be continued by the investigatorThe subject have to discontinue drug upon the occurrence of any of the following (including but not limited to)