Limitations and generalization
weakness, CII malocclusion
The weakness of this trial is that for ethical reasons, an untreated control group cannot be used.The sample size is based on power analysis, but a greater sample size would provide a higher level of evidence. The analyses are based on values of 46 participants who attended either CHG is a removable appliance, and co-operation is essential for successful treatment. Orthodontists cannot monitor how patients follow instructions. Two of the participants in both groups did not reach Class I relation of the molars during CHG therapy.The main strength of this trial was the long follow-up period. There are no previous studies evaluating the long-term effects of CHG on dental arches. Thus, the present results provide valuable information in the field of long-term treatment effects.The present results confirm that CHG is a viable appliance in the treatment of CII malocclusion between 7.5 and 11.5 years of age.