3.1. Transcriptomic analysis of lymphoblastoid cell lines
death, Death, necrosis
GRAFT-VERSUS-HOST DISEASE, DISEASE, ADHESION, NECROSIS
We identified 3093 genes that showed significant differential expression in the LCLs after Among the gene sets that were enriched in up-regulated genes, we found pathways involved in “Cell growth and death” (p53 signaling pathway, Apoptosis, Necroptosis; Regulation by c-FLIP, Caspase activation via Death Receptors in the presence of ligand, RIPK1-mediated regulated necrosis), “immune system” and “immune disease” (Graft-versus-host disease, NOD-like receptor signaling pathway, Allograft rejection; Interferon alpha/ beta/ gamma, Interleukin-2 / -4/ -10/ -13/ -35 signaling), “Signal transduction” (TNF, NF-kappa B, Phosphatidylinositol, FoxO, JAK-STAT) and “Signaling molecules and interaction” (Cell adhesion molecules, Cytokine-cytokine receptor interaction, ECM-receptor interaction; Signaling by KIT in disease, Among the down-regulated gene sets, we identified pathways involved in 