Trial design and oversight
We conducted an investigator-initiated, parallel, double blinded, randomized controlled trial at an academic reference center in Mexico, in a medical-surgical intensive care unit (ICU). The study was approved by the institutional review board “Comité de Ética en Investigación Hospital Civil Fray Antonio Alcalde” (HCG/CEI-0252/17) and performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments. This trial was registered at clinicaltrials.gov (NCT04446871) after inclusion of 17 patients. Informed consent was obtained from all patients or decision makers.