Discussion
PONV, vomiting, patients-specific
In this trial, anisodamine was creatively used on ST36 acupoint injection in female patients during LSG. During the first postoperative 24 h, we successfully observed a significant reduction of the incidence of vomiting, an increase of the time to first rescue antiemetic, as well as less rescue antiemetic in patients with anisodamine injection. It’s noted that ST36 acupoint injection without or with anisodamine had no effect on the early recovery in the hospital and quality of life after discharge.Since female gender is one of the strongest patients-specific predictors among recognized independent risk factors for PONV [Anisodamine, scopolamine and atropine are common tropine alkaloids with similar pharmacological effects [Acupuncture, as a nonpharmacologic prophylaxis therapy, has been proposed as an alternative option for multiple multimodal antiemetic therapy because of its safety and affordability [In addition to prophylactic antiemetics, minimizing opioid use through multimodal analgesic regimens can also be effective in reducing the risk of PONV. We established a multimodal analgesic regimen, including perioperative administration of dexmedetomidine and transverse abdominal plane block, in the standardized GA protocol to partially reduce the risk of PONV. A meta-analysis including 697 participants underwent bariatric surgery also indicated that dexmedetomidine significantly reduced PONV in post anesthesia care unit and POD1 with OR from 0.24 to 0.28 [