Subjective drug effects and effect durations
DRUG EFFECT
Subjective effects were assessed repeatedly using visual analog scales (VASs) [Time to onset, time to maximal effect, time to offset, and effect duration were assessed using individual effect-time plots of the VAS item “any drug effect” and an onset/offset threshold of 10% of the maximum individual response in Phoenix WinNonlin 8.3 (Certara, Princeton, NJ, USA) [