Ethics approval and consent to participate
This study was approved by the Institutional Ethics Committee of Nara Medical University (protocol approval no.1775, UMIN000030684). The study protocol and procedures were conducted according to the tenets of the Declaration of Helsinki and its subsequent amendments. The principal investigator or coinvestigator provided an explanation regarding the study to each eligible participant, using informed consent documents approved by the review board. Participants who provided written informed consent were registered in this study. We confirmed that informed consent was obtained from all study participants.