Introduction
abdominal pain, vaginal infection, weight gain, mastodynia, acne, headache
SIDE EFFECT, VAGINAL BLEEDING, VAGINAL INFECTION, ACNE
Etonogestrel-releasing contraceptive implant (ENG-IMPLANT) is a single rod implant containing 68 mg of etonogestrel which is user independent and can be used for three years. Main side effects of ENG-IMPLANT are related to irregular vaginal bleeding. Other side effects such as weight gain, headache, acne, mastodynia, abdominal pain, emotional liability and vaginal infection are less frequent [An approach that would triage women who may have side effects and consequently difficulties adhering to ENG-IMPLANT could decrease premature removal. Such approach could be the use of daily oral 75 µg of Desogestrel (DSG) prior to the insertion of ENG-IMPLANT. In fact, DSG is transformed into its active form, etonogestrel, after hepatic metabolism and a very similar side effect profile has been described between ENG-IMPLANT and DSG users [This prospective randomized study aims to evaluate if the pre-treatment with DSG prior to ENG-IMPLANT insertion (I) increases the continuation rate at one year, if it (II) increases the tolerance of the implant and (III) to compare side effects profile of DSG and ENG-IMPLANT at 3 months.