Plasma HIV-1 RNA kinetics after ART interruption
To determine the impact of the interventions on ART-free virologic control, all participants underwent a closely monitored 25-week ATI. The study’s primary endpoint was time from stopping ART to the date of meeting the criteria for loss of virologic control (defined as 4 weeks with sustained plasma HIV-1 RNA ≥1,000 copies per milliliter or two consecutive measurements >100,000 copies per milliliter). All participants in the placebo/placebo group experienced loss of virologic control, which occurred at a median of 4.5 weeks (IQR: 3.0–11) after stopping ART (Fig. 