Secondary outcomes
lower BSID-III cognitive
A total of 391 (87%) infants survived to the final endpoint and received a BSID-III evaluation at a median age of 24.7 months (IQR 23.9–25.9). Cognitive scores were available for 390 infants, while language and motor scores were available for 385 infants each. Compared to survivors with no injury on MRI, those with severe injury had significantly lower BSID-III cognitive (adjusted mean difference −8.1, 95% CI −10.2, −6.0), language (adjusted mean difference −7.7, 95% CI −10.3, −5.1), and motor (adjusted mean difference −9.4, 95% CI −11.7, −7.1) scores. In contrast, infants with mild or moderate injury did not exhibit significantly different BSID-III scores than infants with no injury (Fig. 