Introduction
cancer, breast cancer
CANCER, BREAST CANCER
In 2020, breast cancer was the most frequently diagnosed cancer worldwide, and was the leading cause of cancer mortality in women [Studies investigating poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) have demonstrated prolonged progression-free survival (PFS) and improved ORR versus chemotherapy in patients with metastatic HER2− breast cancer with germline Pamiparib is a novel, investigational, small molecule inhibitor of PARP1/2 that has demonstrated potent antitumor activity, brain penetration, and PARP-DNA complex trapping in preclinical models [Here, we report the safety and efficacy of pamiparib in a phase II, multicenter study in Chinese patients with locally advanced or metastatic HER2− breast cancer harboring germline 