Author Contributions
The protocol was designed and developed by R.F., T.L.N., L.V. and M.C. R.F., M.C. and G.R.P. had access to all the raw data. Statistical analysis and data analysis were performed by G.R.P., M.J.A. and M.I. First version of the manuscript was developed by R.F., T.L.N. and M.C. with final input from all authors. M.B. and C.S. also provided administrative support. D.C. also performed analysis and provide input of quality of life questionnaires. Accrual per physician: M.C. (26), T.L.N. (5), R.F. (12), J.R. (1), P.B. (1). All authors have read and agreed to the published version of the manuscript.