Mean Plasma Concentration vs Time Profiles for (A) Δ9-THC, (B) 11-OH-Δ9-THC, and (C) Δ9-THC-COOH
PD, Δ9-THC
Mean plasma concentration vs time profiles for (A) Δ9-THC, (B) 11-OH-Δ9-THC, and (C) Δ9-THC-COOH. Horizontal axes are not accurate time scales and represent the time points at which subjective drug effects were assessed following cannabis administration. Panels D, E, and F depict area under-the-curve ratios of 11-OH-Δ9-THC:Δ9-THC, Δ9-THC-COOH:Δ9-THC, and Δ9-THC-COOH:11-OH-Δ9-THC, respectively. Error bars indicate standard error of the means. The sample size was 18 for all outcomes. CBD indicates cannabidiol; CYP, cytochrome P450; Δ9-THC, Δ9-tetrahydrocannabinol; Δ9-THC-COOH, 11-nor-Δ9-tetrahydrocannabinol-carboxylic acid; 11-OH-Δ9-THC, 11-hydroxy-Δ9-tetrahydrocannabinol.No significant effects of time were observed in the placebo brownie condition, indicating the CYP cocktail was not associated with a significant change on any of the assessed PD outcomes. The main effects of dose, time, and dose × time interactions were observed across all outcomes within the 4 subjective drug rating categories (ie, general drug effects, positive, negative/adverse, and perceived degree of impairment) (eTable 2 in 