4. Discussion
bradycardia, hypotensive, cytokinesis-block micronucleus cytome
MINOR, DNA DAMAGE, GENOTOXICITY, HYPERTENSIVE EPISODE, EVENTS, OXIDATIVE STRESS, HYPOTENSIVE
Anesthesia describes as one of the principal medical developments and considered as well-organized specialty due to the discovery of modern drugs, new equipment, and progress of new methodologies today. However, practice in this field produce disputes regarding safety of both patients and providing personnel. Smoking played a contributing role in the higher occurrence of genotoxicity, so the designed study excluded smokers and elderly patients. In our study, prolonged procedures were selected to evaluate the genotoxic effects of ISO because DNA damage was not reported in minor procedures [In the present study, the highest value of comet tail length was seen after 8 h of anesthesia induction (In another study, exposure to ISO in infants NHPs (nonhuman primates) for 5 hours results in an increase in apoptosis status to 13 times compare with the control group [Previous study shown that the micronucleus frequencies in Propofol and DEX group were lower than in midazolam group evaluated by cytokinesis-block micronucleus cytome assay (CBMN) of peripheral blood lymphocytes of surgical patients suggesting that the level of oxidative DNA damage were higher at induction and decreased with time following DEX administration [Plasma MDA enzymatic activity is an important marker to access the oxidative stress caused by ISO [MDA serum level was significantly reduced by DEX in human patients undergoing pulmonary aortic surgery when used at infusion dose in general anesthesia [Most of the selected patients were undergoing neurosurgical procedure for the better hemodynamic control. DEX, having sympatholytic properties, could be a potential useful anesthetic adjuvant in neurosurgical procedures. Moreover, continuous infusion of DEX was effective for blunting response in systolic blood pressure and provided better hemodynamic control. In our study, systolic blood pressure and heart rate were examined by continuous computerized record with reference to targeted range at particular time points without increasing the frequency of hypotensive events or bradycardia, considered as common side effects of this drug. No difference was seen in the number of hypertensive episodes per hour. Moreover, no patient received treatment for bradycardia intraoperatively in either group.