Discussion
death, NDI, anemia
SECONDARY, ANEMIA
This prospective secondary analysis of the TOP randomized clinical trial found that RBC transfusion was associated with an increase in regional oxygenation of both brain and mesenteric tissue despite no change in SpOSimilar to several observational, single-center studies, we also found a significant increase in both Csat and Msat after transfusion and a decrease in fractional tissue oxygen extraction.Although we expected a greater increase in tissue saturation among infants with worse anemia, Csat and Msat increased to a similar extent in both the restrictive and liberal transfusion threshold groups, with corresponding decreases in cFTOE and mFTOE. Other investigatorsIn pursuing our secondary, hypothesis-generating objective to explore the association of cerebral NIRS measures and other clinical factors with the adverse composite outcome of NDI or death,The utility of Hgb as a measure of adverse outcome in the preterm population remains unclear. Notably, the Hgb threshold arm for transfusion was not found to be a significant variable for adverse outcome in either modeling process, echoing findings from the larger TOP trial.