Summary of findings
Taking into account all the above, in the COC group compared to the placebo group, the within-network connectivity increased during treatment in the DMN, whereas it decreased in the SN and ECN. Regarding the between-network connectivity, specifically from the dACC (SN) to medial nodes of DMN, effective connectivity was increased in the COC group compared to the placebo group. From the rAG (posterior DMN) to the SN, effective connectivity increased in the placebo group compared to the COC group. Conversely, effective connectivity increased from the rAG to the posterior ECN in the COC group compared to the placebo group. Effective connectivity from the frontal ECN to the DMN was in general stronger during treatment in the placebo than in the COC group, while those connections originating in the lSMG followed the opposite pattern. In general, effective connectivity between the ECN and the SN was stronger in the COC group compared to the placebo group.