Correlates of durable response
T CELL DYSFUNCTION
Thirteen of the 62 treated patients (21%) achieved a PFS interval of ≥18 months. These results were used to identify apheresis PBMC and DP correlates of long-term response to ide-cel. T cell phenotyping via standard flow cytometry was performed on both the PBMC starting material from apheresis and DP to evaluate T cell memory subsets, phenotypes associated with senescence and T cell dysfunction, and anti-BCMA-stimulated CAR T cell activity via interferon (IFN)-γ secretion of the DP. Statistically significant correlates of long-term response included a higher percentage of naive and early memory (CD28