Overview
This study was a multi-center RCT with a parallel design, in which the effects of two types of titratable MADs on respiratory parameters and upper airway dimensions were compared. The allocation sequence was automatically generated through an electronic data capture system (Castor EDC), using random block size of either 4, 6, or 8 with an allocation ratio of 1:1. The Medical Research Ethics Committee of the Academic Medical Center Amsterdam (AMC) approved this study (#: NL44085.018.13). The study was registered at clinicaltrials.gov (ClinicalTrials.gov identifier: NCT02724865). Written informed consent was obtained from all participants.