Conclusions
These results illustrate the variable influence of different contraceptives on the FGT host environment with Cu-IUD insertion resulting in the highest perturbation of the endocervical transcriptome, mainly related to immune responses, as compared to DMPA-IM and LNG implant initiation. DMPA-IM use led to an enrichment of pathways associated with T cell responses and a reduction of pathways associated with growth and metabolism while LNG implant initiation was associated with enrichment of growth factor signaling.The following are the supplementary data related to this article.