RESULTS
±, GTCS, seizures, seizure
ADVERSE REACTION
The entrance requirements were satisfied by 60 patients in total. Thirty individuals were given melatonin, and the other 30 were given a placebo. The patients in the valproic acid + melatonin group and valproic acid + placebo group did not differ significantly regarding mean age (38.49 ± 9.1 vs. 36.83 ± 12.7 years) and sex (male: 63% vs. 70%). No adverse reaction was observed from the melatonin therapy. The baseline characteristics of patients are shown in Table Demographic and clinical characteristics of the study populationAbbreviations: EEG, electroencephalogram; GTCS, generalized tonic‐clonic seizure; MRI, magnetic resonance imaging.The assessment of the severity of seizures showed that melatonin significantly reduced the severity of seizures, while placebo did not change this trend. After a washout period, the severity of seizures slightly increased, and after exchanging the groups, again, melatonin significantly reduced the severity of seizures (Table Assessment of the severity of seizures between the study groups before and after treatment (scoring based on Chalfont questionnaire scale)Assessment of seizure frequency between the study groups before and after treatmentEvaluation of the seizure frequency among patients showed that neither melatonin nor placebo significantly reduced the seizure frequency in the first and second periods after treatment (Table Also, the results of EEG interpretation were compared among patients in both groups and showed that melatonin and placebo did not make a significant difference in the EEG status (Qualitative assessment of electroencephalogram (EEG) interpretation between the study groupsThe assessment of the quality of sleep, according to the Pittsburg questionnaire, showed that melatonin significantly increased the quality of sleep, while placebo did not change this trend. After a washout period, again, melatonin significantly improved the quality of sleep (Assessment of the quality of sleep between the study groups before and after treatment