1. Introduction
dysbiosis
DENTAL CARIES, DISEASES
The aim was to test if probiotics counteract oral dysbiosis during 14 days of sugar stress and subsequently help restore oral homeostasis. Eighty healthy individuals received either probiotics (The oral microbiota is comprised of more than 700 bacterial species, making the oral microbiota the second most complex found in the human body [In oral health, the oral microbiota thrives with the human host, whereas dysbiotic compositional changes are associated with development of oral diseases [Probiotics are live microorganisms, which, when administered in adequate amounts, confer a health benefit on the host [Free sugars constitute the most important dietary risk factor for the development of dental caries [Recently, we showed that intake of probiotic lozenges containing an equal mix of We therefore hypothesized that in a randomized, double-blinded clinical trial, a daily supplement of probiotics would counteract the detrimental effects of 14 days of sugar stress on the supragingival microbiota and help restore oral homeostasis over the subsequent 14 days, when sugar stress is terminated in systematically and orally healthy individuals. The aim of the present study was to determine if consumption of probiotic lozenges containing an equal mix of 