1. Introduction
senile infertility, kidney qi deficiency, TCM
In 2016, China implemented fully the “two-child policy,” and since then, the proportion of elderly women who want to have children has been increasing.Since the birth of the first test-tube baby in 1978,Presently, metabolomics, as a powerful analytical tool, has been applied in many fields such as biomarker discovery and traditional Chinese medicine (TCM) research, to enhance our understanding of chemical communication.Based on previous findings, this study sampled elderly patients with kidney qi deficiency who planned to undergo IVF. A randomized controlled trial was adopted to conduct a scientific and standard evaluation on the outcome of elderly women IVF-assisted pregnancy with acupuncture. Targeted metabonomic analysis of follicular fluid with HPLC-MS technology is expected to provide a scientific basis for the wide application of acupuncture in ART, and new ideas and methods for the adjuvant treatment of senile infertility patients with kidney qi deficiency.