Conclusions
different neurologic domains
In this exploratory post-hoc analysis, digital measures obtained with the Floodlight PoC app correlated with normalized volumes of distinct anatomical regions. While many of the correlations were also observed with standard clinical measures, some were only observed with the digital measures. In addition, the explained variance analysis may suggest a higher functional specificity for digital measures, in particular in the upper extremity function domain. These results indicate that digital measures, by leveraging sensor technology, can probe multiple different neurologic domains rather than just providing an overall assessment of functional ability. Thus, digital measures have the potential to complement standard clinical measures by providing a more detailed picture of MS and a more accessible assessment of functional ability. Larger, ongoing, and forthcoming studies will need to confirm these preliminary findings.