5. Conclusions
cardiometabolic disease, ASCVD, prediabetes, arterial stiffness, T2DM
PREDIABETES, ASCVD, ARTERIAL STIFFNESS, ENDOTHELIAL DYSFUNCTION
We showed for the first time that carnosine supplementation has no beneficial effects on cardiovascular parameters, including arterial stiffness and endothelial dysfunction, or other cardiometabolic disease indicators, such as blood pressure, heart rate, kidney and liver function, and lipid parameters in adults with normal levels of cardiovascular and cardiometabolic parameters. Whether carnosine supplementation can reduce ASCVD risk or improve metabolic outcomes in patients with prediabetes and T2DM with more elevated cardiovascular risk factors needs to be confirmed.