Results
A total of 75 Patients were enrolled between February 15 and July 31, 2022. Figure 
Flow diagramBaseline patient characteristics are shown in Table 
Baseline patient characteristicsASA, American Society of Anesthesiologists; BMI, body mass index; MAP, mean arterial pressure; HR, heart rate. Data are summarised by number (%), median (interquartile range) or mean (standard deviation). Intraoperative characteristics were shown in Table 
Intraoperative characteristicsASA, American Society of Anesthesiologists; BMI, body mass index; MAP, mean arterial pressure; HR, heart rate. Data are summarised by number (%), median (interquartile range) or mean (standard deviation). 
Changes in the MAP, HR and BIS over time in two groups (Figure 
Changes in the CD4+/CD8 + ratio, CD3 + T cell and NK cell were not significantly different in the two groups (Figures 
Changes in CD4 + T cell was not significantly different in the two groups (
Changes in CD8 + T cell was not significantly different in the two groups (Data on the serum cytokines are shown in Table 
Perioperative Cytokine ConcentrationsData are expressed as median (interquartile range) or mean ± SD with difference (95% CI).TIL = Interleukin; VEGF = Vascular Endothelial Growth Factor; IFN = Interferon.Postoperative characteristics is presented in Table 
Postoperative characteristicsData are summarised by number (%), median (interquartile range) or mean (standard deviation). POD1 NRS score, the numerical rating scale score at 1 day postoperatively. Analgesic pump drug residual volume, the analgesic pump drug residual volume at 24 h postoperatively. 