Introduction
sleep disordered breathing complaints
BACTERIAL DISEASES, CHRONIC ADENOIDITIS, MIDDLE EAR INFECTION, RHINOSINUSITIS, INFLAMMATIONS, MIDDLE EAR
Chronic adenoiditis (CA) is a common condition in pediatric otorhinolaryngological clinical practice, frequently associated with chronic or recurrent middle ear infections, rhinosinusitis, and sleep disordered breathing complaints; these situations often require specialist consultations, antibiotic prescriptions and, in some cases, surgical treatment [Chronic or recurrent inflammations of the nasopharyngeal and middle ear district are generally bacterial diseases, mainly sustained by an infectious focus located within the nasopharynx or in the deep adenoidal pads; it is characterized by a complex interplay between different bacterial species, sometimes within the setting of a resistant bacterial biofilm [Based on this, current therapeutic management of children with CA should overcome the emerging issue of increasing resistance of bacterial biofilm to traditional antibiotic treatment (which is up to 10–1000 higher than the one reported for the corresponding planktonic species), and be modulated to target the individual respiratory microbiome. Under these circumstances, some studies have suggested the effectiveness of topic probiotic treatment by means of The aim of this study was to assess the efficacy and safety of the topical nasal administration of a probiotic compound based on 