External validation
Comparison of the DICE scores computed on Dataset2 (12 patients) between segmentations resulting from CNN1 to CNN4 and manual segmentations are shown on Fig. Barplots of the DICE scores (mean and standard error) computed on each lesion and on overall lesions between automatic and manual segmentations on Dataset2 (12 patients—12 CT-scans). Upper part shows the comparison of CNN1 (grey) and CNN2 (white). Lower part shows the comparison of CNN3 (grey) and CNN4 (white). Significance was assessed with non-parametric two-side Wilcoxon tests.*p < 0.05, **p-value < 0.01.