What this study adds
heart failure, cardiovascular death, Thomas
MYOCARDIAL INFARCTION, MOORE, HEART, STUART, WELLS, WEST, CROSS, HEART FAILURE
The GRS did not improve the use of guideline recommended management for NSTEASC or reduce a composite of cardiovascular death, non-fatal myocardial infarction, new onset heart failure hospital admission, and readmission for cardiovascular eventThe use of the GRS compared with standard care did not reduce the duration of hospital stay or improve health related quality of life measured using EQ-5D-5L (five domain, five level version of the EuroQoL index)Barking, Havering and Redbridge University Hospitals (Dr Honer Kadr), Bradford Royal Infirmary (Dr Steven Lindsay), Calderdale Royal Hospital/Huddersfield Royal Infirmary (Dr Jeremy Butts), Castle Hill Hospital (Dr Richard Oliver), Conquest Hospital (Dr Robert Gerber), East Surrey Hospital (Dr Ansuman Saha), Frimley Health—Wexham Park (Dr Mohammed Al-Obaidi), Great Western Hospital (Dr Tom Hyde), Harrogate District Hospital (Dr Bogumila Oledzka), Imperial College Healthcare—Hammersmith Hospital (Dr Piers Clifford), Kingston Hospital (Dr Tapesh Pakrashi), London North West—Ealing Hospital (Dr Stuart D Rosen), Luton and Dunstable Hospital (Dr Christopher Travill), Northampton General Hospital (Dr Patrick Davey), Northumbria Healthcare (Dr Iain Matthews), Royal Oldham Hospital/North Manchester General Hospital/Fairfield General Hospital (Dr Jolanta Sobolewska), Papworth Hospital (Dr Stephen Hoole), Pinderfields General Hospital (Dr Philip Batin), Plymouth Hospitals NHS Trust—Derriford (Dr Girish Viswanathan), Royal Blackburn Hospital (Dr Scot Garg), Royal Bournemouth Hospital (Dr Terry Levy), Royal Cornwall Hospital (Dr Sen Devadathan), Royal Shrewsbury Hospital and Princess Royal Hospital Telford (Dr Thomas Ingram), Royal Sussex County Hospital (Dr David Hildick-Smith), Salisbury District Hospital (Dr Tim Wells), Sandwell and Birmingham City Hospitals (Dr Vinoda Sharma), Sherwood Forest Hospitals (Dr Sukhbinder Bassi), South Tyneside and Sunderland NHS Foundation Trust (Dr Shahid Junejo), Torbay Hospital (Dr Philip Keeling), University Hospital Lewisham (Dr Khaled Alfakih), University Hospitals of Morecambe Bay NHS Trust (Adrian Brodison), University Hospital of North Tees (Justin Carter), Victoria Hospital, Blackpool (Dr Ranjit Moore), West Middlesex University Hospital (Dr Francesco LoMonaco), Whipps Cross (Dr Anil Kumar Taneja), Worcestershire Royal Hospital (Dr Helen Routledge), Wycombe General Hospital (Dr Piers Clifford), Yeovil District Hospital (Dr Andrew Broadley), York Hospital (Dr Chris Hayes).We gratefully acknowledge Colin Everett for his input into the statistical analyses.Extra material supplied by authorsWeb appendix: AppendixContributors: CPG, KF, LDS, and DDS are guarantors and responsible for the study design and protocol development. DDS performed the analysis. CPG drafted the manuscript and all authors approved the final manuscript. The corresponding author attests that all listed authors meet authorship criteria and that no others meeting the criteria have been omitted.Funding: The British Heart Foundation funded the trial (CS/16/2/32145). The funders had no role in considering the study design or in the collection, analysis, interpretation of data, writing of the report, or decision to submit the article for publication.Competing interests: All authors have completed the ICMJE uniform disclosure form at The lead author (the manuscript’s guarantor) affirms that the manuscript is an honest, accurate, and transparent account of the study being reported; that no important aspects of the study have been omitted; and that any discrepancies from the study as planned (and, if relevant, registered) have been explained.Dissemination to participants and related patient and public communities: Results will be shared with participants at cardiovascular meetings. A lay summary of the findings will be published on funder website and social media platforms.Provenance and peer review: Provenance and peer review: Not commissioned; externally peer reviewed