CAR-T cell peak numbers in patients treated with CLDN6 CAR-T cells +/- CARVac.
Peak numbers were reached on average within 18 days (range 17–24) for patient treated at DL1 (circles) and 15.6 days (range 8–24) for patients treated at DL2 (squares). 3 patients treated at DL1 received CARVac 4 days after ACT, 7 patients treated at DL2 received CARVac on day ≥ 23 post-ACT. Numbers are presented as CAR copies per µg genomic DNA. Shown are patients treated with LD, peak CAR-T number for one patient treated with a 50% reduced course of LD is shown as a non-filled square. Box plots show median and upper and lower quartiles, with whiskers indicating 1.5x the interquartile range. Individual data points are overlaid.
