3.3. Statin withdrawal effects on anthropometry and metabolic variables
muscle damage, tissue damage
DRUG WITHDRAWAL, DYSFUNCTION
No changes to anthropometric measures were observed following statin withdrawal in either the SAMS or No SAMS groups (In addition, and as expected, a significant deterioration of the lipid-lipoprotein profile was seen in all statin users following drug withdrawal. Indeed, repeated-measures ANOVA analyses revealed several time x category interactions for most lipids (With respect to markers of tissue damage or dysfunction, while ALT and AST levels are somewhat reduced following withdrawal of the drug, these values always remained well below clinical thresholds. The muscle damage specific markers MB and CK did not differ across groups or change following statin withdrawal and remained well below clinical values of clinical concern throughout the study (Finally, despite a small decrease in 25(OH)D