Highlights
HIV-1 neutralizing antibodies 2C06 and 2C09 from VRC 018 clinical trial are isolatedCryo-EM structures of 2C06 and 2C09 in complex with HIV envelope trimer are determined2C06 and 2C09 binding requires a glycan hole at 241 and BG505-specific residuesAntibodies 2C06 and 2C09 form a reproducible class, recognizing fusion peptide