Gene expression signature analysis on integrated RNA sequencing data
A collection of 709 gene expression signatures derived from the literature and partially summarized beforeThe signature scores were computed by calculating the median expression of all the genes within a signature. Multiple immune-related biomarkers were included in this gene-signature collection, most of them initially extracted by comparing the gene expression pattern of different immune cell sub-populationsSignature scores were then centered removing their mean and scaled dividing them by their standard deviation in the two studies. We next computed the correlation of the signature scores with the prognostic score as continuous value (considering as significant correlations with 