Strengths & limitations
weight loss
INSULIN SENSITIVITY
The strengths of this investigation are the excellent trial design and the double blinding of both participants and investigators. The testing of compliance to all aspects of intervention every fortnight, an individualized weight loss strategy, provision of sample menus and telephone contact to assist adherence to study requirements, were other favourable facets. We acknowledge that the short duration of the trial may not have allowed the full impact of leucine on all aspects of body composition, as well as changes in insulin sensitivity markers. Additionally, the gender bias observed needs replication as fewer men than women were studied.