Transcriptomics
tumor
TUMOR
Changes to gene expression patterns and signature scores at baseline and after treatment can reflect a changing tumor microenvironment (TME) and may be useful for understanding the impact of olaparib on tumor cells. By comparing signature scores after treatment to the scores at baseline, changes in the tumor-immune landscape can be visualized. In this study, we found that macrophage and stromal tissue signatures were significantly higher post-olaparib–based treatment (Differentially expressed genes (