Differential Variable Positions
Crohn’s disease
DISEASE, RECURRENCE, ULCERATIVE COLITIS
Differential methylation variability was assessed using the iEVORA method comparing patients with disease recurrence and those without (using the clinical end point). There were 18 differentially variable positions (DVPs) associated with disease recurrence. When covariates were additionally used (age, sex, smoking status, cell proportions), there were 5 significant DVPs associated with disease recurrence (Top Table of Differentially Variable Positions in Patients With Disease Recurrence Postresection for CD Using Clinical End PointNOTE. Calculated with the iEVOR method. A matrix of residual methylation values of a linear model including the following covariates was used (age, sex, smoking status, treatment/placebo, cell proportions).Defined as increase in Crohn’s disease activity index of more than 150 and an increase of 100 points from baseline measurement and institution of immunosuppressive treatment or further surgery.The biologic and functional relevance of DMPs and DVPs associated with CD recurrence following surgery are outlined in Functional and Biologic Relevance of Significant Differential Methylated Positions and Differentially Variable Positions Associated Crohn's Disease Recurrence Following SurgeryIBD, inflammatory bowel disease; UC, ulcerative colitis.