Author contributions
RS, JJ
TP, YN, EL, RT, M, RS, and NS contributed to the design, implementation, and analysis of the phase I trial. JJ, TP, MY, ES, RI, and BR contributed to the design, implementation, and analysis of the phase II trial. JJ, ES, RI, ES, and YN wrote the manuscript. All authors contributed to the article and approved the submitted version.