Panel of immune-related genes and signatures expression analysis (non-exhaustive list)
death
DEG analysis between responders and non-responders to anti-PD1/PD-L1 immunotherapy will be performed including:IFN-γ mediated signalingStimulatory (CD27, CD28, CD40, OX40, glucocorticoid-induced TNFR-related protein (GITR), inducible costimulator of T cells (ICOS),…) and Inhibitory (PD1, B7-H3, B and T lymphocyte attenuator (BTLA), cytotoxic T lymphocyte antigen 4 (CTLA-4), indoleamine 2,3-dioxygenase (IDO), killer cell immunoglobulin-like (KIR), lymphocyte-activation gene 3 (LAG3), T-cell immunoglobulin and mucin domain 3 (TIM3), V-domain Ig suppressor of T cell activation (VISTA),…) immune checkpoint genesHypoxia-related genes (Hypoxia-inducible factor (HIF)-1α; HIF-2α,…)ΔNp63 (p40) gene expression signatureImmune cell gene signaturesImmunogenic cell death (Calreticulin, p-eukaryotic initiation factor 2α (eIF2α),…) and mitophagy-related markers (Bcl-2 interacting protein 3 (BNIP3),…)