Introduction
inflammation
CVD, INFLAMMATION, SECONDARY, CARDIOVASCULAR DISEASES
Morbidity and mortality from cardiovascular diseases (CVD) are increasing and represent a major public health problem worldwide [Olive oil is an essential component of the MD, being its primary fat source [To this end, an intervention study has been carried out to assess the possible beneficial role of consuming OPO as the main source of fat in the diet on serum lipid concentrations (primary outcome) and other biomarkers of cardiovascular health such as blood pressure, endothelial function and inflammation (secondary outcomes) in at-risk (hypercholesterolemic, HC) subjects. To further explore the potential effects of OPO, healthy normocholesterolemic (NC) volunteers were also included in the study.