Protocol deviation
Depression, depressed, HRSD
Some PMDD participants (9 of 24) deviated from the design protocol by not self-administering morning light during the active PAI (LWT + AM BWL) portion of the study. A comparison of improvements (percent changes) from baseline mood measures in those who fully complied (At baseline, the cosine-derived 6-SMT offset was significantly correlated with the atypical mood score of the SIGH-ADS in PMDD + NC combined (At baseline, greater depressed atypical mood score of the Structured Interview Guide for the Hamilton Rating Scale for Depression (HRSD) with Atypical Depression supplement (SIGH-ADS) score correlated positively with greater phase-delay in 6-sulfatoxymelatonin (6-SMT) offset (