Study drug exposure
death
The median duration of exposure to the study drug was 58.3 weeks (range 5.1–131.4). The median average daily dose was 23.2 mg (range 9.9–60.0 mg) and the corresponding median relative dose intensity was 38.7% (range 16.5–100.0%). All 35 patients discontinued the trial at the point of data cut-off, which included death (Profile of study enrollment