Study Design
NAFLD
This randomized, parallel-group, observer-blinded clinical trial was designed to compare the effects of 8-hour TRE vs DCR on the IHTG content and metabolic risk factors among patients with NAFLD. Eligible trial participants were randomly assigned to the TRE or DCR program for 12 months. The duration of intervention of the original study design was 6 months (registered as NCT03786523); at the beginning of the study, we revised the design and prolonged the intervention to 12 months to compare the long-term effects of TRE vs DCR on NAFLD (registered separately as NCT04988230). The duration of the intervention included the original designed 6 months and the next 6 months follow-up visits. The trial protocol and statistical analysis plan are available in 