Decreased ILC2 milieu activation ability of PBMCs induced by HDM and stimulating factors after SLIT
allergic rhinitisAfter
POSITIVE
Both ILC2 frequency and ILC2-related cytokine (IL-5/IL-13) production in PBMCs were significantly inhibited in the SLIT group after 2-year SLIT treatment (ILC2: 0.040 ± 0.022 vs 0.043 ± 0.024, After stimulation with HDM (20 μg/mL) and stimulating factors, no significant change of ILC2 frequency in PBMCs from SLIT group. Two-year SLIT decreased the ILC2 milieu activation ability in AR donor. #P > 0.05. HDM, house dust mite; ILC2, type 2 innate lymphoid cells; PBMCs, peripheral blood mononuclear cells; SLIT, sublingual immunotherapy; ILC2, type 2 innate lymphoid cells; AR, allergic rhinitisAfter stimulation with HDM (20 μg/mL) and stimulating factors, significant upregulation of ILC2 frequency in PBMCs from the control group. *Positive correlation between levels of ILC2 and cytokines (IL-5/IL-13) after stimulation in the control group after 2-year treatment. ILC2, type 2 innate lymphoid cells; IL, interleukin