Introduction
bleeding, stroke, tooth socket bleeding, venous thromboembolism, atrial fibrillation, drug-induced bleeding, tooth
ATRIAL FIBRILLATION, STROKE, BLEEDING
Patients with drug-induced bleeding disorders need special attention in oral and maxillofacial surgery [Since most anticoagulants’ use is limited because of parenteral administration, frequent monitoring, and dose adjustments, novel small-molecule, oral, direct factor Xa (FXa) inhibitors were developed [Nowadays, FXa inhibitors such as rivaroxaban, apixaban, and edoxaban are used for therapy and prevention of venous thromboembolism, stroke prevention in patients with atrial fibrillation [Although hemostatic sponges are considered a gold standard for managing tooth socket bleeding, there is no proof of their efficiency after surgical procedures in the maxillofacial area in patients under FXa inhibitors [Thus, in this clinical prospective randomized, double-blinded split-mouth study, the local hemostatic effect of autologous PRF as inserted into the extraction teeth socket in patients taking direct FXa inhibitors is to be compared to the hemostatic gelatine sponge (GS) as the “therapeutic gold standard” without withdrawal of oral anticoagulant therapy. The study’s primary aim was to define the most reliable method for hemostasis after tooth extraction without withdrawing FXa inhibitors. Secondary outcome was if PRF controls bleeding in the early postoperative stages better than GS in the same cohort of patients.