2.3.3. Missing Data
For the economic evaluation, missing data were imputed using multiple imputation, with 100 imputed datasets. Predictors in the imputation procedure included inclusion period (control/intervention), sex, age, EQ-5D utilities, medication costs, GP cardiovascular risk management (CVRM) costs, GP other costs and total medical specialist outpatient costs (Analyses were performed with SPSS version 25.0.02 and R version 2022.02.0, lme4 and ordinal packages.