Acknowledgements
We gratefully acknowledge the IPCRG for introducing us to the primary care networks involved in this study and for its continued facilitation of clinical engagement; the trial steering and international scientific advisory committees: Debbie Jarvis, Niels Chavannes, Semira Manaseki-Holland and David Mannino; all the participants and staff of participating general practices. Biljana Tanevska for management support for the trial.