Author contributions
M.Y.L. and X.L. collected clinical sample, clinical data, performed the statistical analyses and wrote the manuscript. H.Z. performed the bioinformatic analyses. M.Y.L. designed iTRAQ experiments and provided samples. L.Z. and L.S. were involved in experimental design, data collection, data analysis, and interpretation. M.Y.L., Huan.Z. collected clinical data and conducted follow-up. M.Y.L., X.L., L.Z., L.S., W.X.L., G.L.P. collected clinical sample and conducted Elisa. J.Q.S. participated in manuscript revision. M.L. is the principal investigator, designed the study, wrote the manuscript, and was responsible for clinical interpretation. All authors reviewed and edited the manuscript. M.L., H.T.Z. and Z.S. are the guarantor of this work and, as such, had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.