Background
psychotic symptoms, treatment-resistant depression, psychosis
“Dissociation” comprises distinct phenomena, some of which are associated with esketamine treatment and some may overlap with positive symptoms of psychosis. Relationships between dissociation and psychotic symptoms assessed by ­clinician report vs conventional rating scales were investigated in a post hoc analysis of data from the initial treatment session in an ­open-label, ­long-term safety, phase 3 study of esketamine plus a newly initiated oral antidepressant in patients with treatment-resistant depression.