Subgroup and Sensitivity Analyses
depression, anxiety
Subgroup analyses for all outcomes (including test for interaction between stratification variables and intervention on all vocational outcomes) are shown in Supplement 6. Only selected and significant subgroup or interaction analyses for outcomes at 24 months are described here. When comparing INT with the other two groups, interaction was seen for the variable baseline diagnosis (anxiety vs. depression) on RTW rates and proportion in work. This was supported by subgroup analyses of persons with anxiety in which the MHC group showed considerably poorer vocational outcomes than the other groups. This tendency was not seen among participants with baseline depression; here, no significant differences between the three groups were observed.In the small subgroup of participants without employment at baseline (132 of 609, 21%), the INT group had worked 39.4 weeks (SD 7.6) at 24-month follow-up. In the other groups, the number was 28.6 weeks (SD 7.0) for SAU and 27.3 weeks (SD 6.6) for MHC. Yet, these differences were not statistically significant (p-values 0.17 and 0.08, respectively).Sensitivity analyses of all questionnaire outcomes are shown in Supplement 7. Best/worst-case scenarios showed substantial deviations from the main results. This was expected because of the low response rates and large differences in response rates between trial arms (between 56.7% and 66.5%).