Physical activity intervention
Individuals in the placebo + PA and LTP + PA groups participated in the PA intervention. The PA intervention consisted of weekly supervised and home-based sessions.During the supervised sessions, exercises were performed using a cycling ergometer (900U; COMBI WELLNESS, Japan). During exercise, the heart rate was monitored using the ear sensors on the cycling ergometer. Exercise intensities and durations are listed in Supplemental Table In a supervised session, we educated the participants on MVPA at home. Accelerometer data were used to provide weekly feedback on MVPA time and step counts. The feedback sheet also included a graph showing the change in MVPA time over the intervention period. The participants were instructed to aim progressively to achieve the goals listed in Supplemental Table 