Sequence generation, allocation concealment, and implementation
Participants who meet criteria for inclusion will be stratified into two groups (i.e., < 40 years of age or IDU or ≥ 40 years and no IDU) then randomly assigned using variable block randomization for each stratum to one of the two study arms. Sequence of random assignments will be generated in SAS Enterprise Guide Version 7.1 (SAS Institute, Inc., Cary, NC) and transferred into REDCap (Vanderbilt University, Nashville, TN) for use with enrollment. Integration of the randomization sequences into REDCap will allow for concealed allocation as research assistants will not be able to anticipate allocation. As such, patients who consent for participation will be randomly assigned to one of the two study arms by a research assistant.