Free C5 concentration
RARE DISEASE
Concentrations of free C5 in serum (as a measure of target engagement) were measured using a validated microfluidics assay with fluorescence detection. The assay has sensitivity (lower limit of quantification) of 0.0183 µg/mL and precision (coefficient of variation) of ≤ 15.6% (Alexion, AstraZeneca Rare Disease, data on file).