Methods
acute respiratory failure
ACUTE RESPIRATORY FAILURE
This was a prospective randomized controlled open-label trial. Patients
diagnosed with intensive care unit-acquired weakness were consecutively
enrolled based on a Medical Research Council score ≤ 48/60. The
patients randomly received two daily sessions; in the control group,
conventional chest physiotherapy was performed, while in the intervention
group, chest physiotherapy was associated with mechanical
insufflation-exsufflation. The incidence of acute respiratory failure within
48 hours of extubation was evaluated. Similarly, the reintubation rate,
intensive care unit length of stay, mortality at 28 days, and survival
probability at 90 days were assessed. The study was stopped after futility
results in the interim analysis.