Correlation between functional connectivity changes associated with the genetic variant and the different pharmacological contrasts depending on the selected number of regions ranked by the expression of target genes.
Connectivity changes related to the genetic variant (C-allele) are positively correlated with the contrasts ketamine > placebo as well as ketamine > midazolam and negatively correlated with the contrast midazolam > placebo. Absolute magnitude of correlation increases when iteratively removing regions with lower expression of the target genes. For the calculation of the p-values, we first created a null distribution of correlation curves and the respective areas under the curves (AUCs) by applying 10,000 random permutations of the genotype variable. Then we determined the percentage of AUCs exceeding (for the contrasts ketamine > placebo and ketamine > midazolam) or falling below (for the contrast midazolam > placebo) the observed AUC. The reported p-values reflect the respective percentages after FDR-correction. Figure 2b, c shows the performance of the correlation curve for each pharmacological contrast as compared to the curves generated by permutation of genotype. Considering the global AUC measure, only the contrasts ketamine > midazolam and midazolam > placebo reached statistical significance: AUC(ketamine > placebo) = 10.65; 