2.7.2. Secondary endpoints.
pain
BLOOD
Changes in the duration of dermal pain induced by thermal load before and after administration of icatibant or placebo.Blood samples will be collected before and after treatment with icatibant or placebo to measure blood and plasma histamine, and serum ACE levels.In patients who consent to a skin biopsy, a skin tissue sample will be obtained to histologically evaluate the pathomechanism of dermal pain. In some patients, a prior skin biopsy may have been performed at the site of dermal pain beforehand in the past clinical practice. If the conditions for obtaining skin samples are consistent with those in this study, the previous specimens would be evaluated to avoid performing another biopsy with patients physical burden.