Adverse events
hypernatremia, hematoma, hemolysis, chronic kidney disease
OXIDATIVE STRESS, ELEVATED GLUCOSE, HYPERNATREMIA, HEMATOMA, HEMOLYSIS, G6PD DEFICIENCY
One patient with chronic kidney disease developed hypernatremia (Na of 161 mmol/L) and a falsely elevated ketone level by point of care device after 50 g of NaAscorbate infusion. Such hypernatremia resolved over 24 h after cessation of the study drug. All glucose levels were measured by blood gas machine and there was no false elevated glucose report. Another patient developed evidence of moderate hemolysis 12 h after NaAscorbate administration had been completed. This occurred in the setting of a large intraperitoneal hematoma being reabsorbed and was accompanied by an increase in methemoglobin. Independent hematological assessment was that the patient had probable NaAscorbate-dependent oxidative stress induced hemolysis. The patient received a blood transfusion and the hemolysis resolved spontaneously over 48 h. The patient was discharged alive from ICU with a stable hemoglobin level and no further evidence of hemolysis after radiological drainage of the hematoma. The patient did not have G6PD deficiency. Both episodes were immediately reported to the Austin Health Human Research Ethics Committee.