Toxicity
toxicity, pneumonitis, skin rash, colitis
PNEUMONITIS, ADVERSE EVENTS, EVENT, EVENTS, SKIN TOXICITY, COLITIS
Fifteen patients (71%) experienced adverse events of any grade possibly or definitely related to treatment. Grade 3 treatment‐related toxicity was reported in three patients; one colitis, one pneumonitis and one skin toxicity. The patient with colitis had to permanently stop treatment due to a recurrent grade 3 event. For the patients with grade 3 pneumonitis and grade 3 skin toxicity, oral prednisolone was administered and atezolizumab was temporarily held for 8 and 3 weeks respectively, until symptoms had recovered to grade 1. In both cases, atezolizumab was successfully restarted. There were no grade 4 or 5 events. The most common adverse events were skin rash (Summary of adverse events.Treatment‐related adverse events. AE, adverse events; ALT, alanine transaminase; AST, aspartate transaminase.