Background
Alzheimer’s disease, neuroinflammation, AD
BRAIN CONDITION, NEUROFIBRILLARY TANGLES, PATHOGENESIS
Alzheimer’s disease (AD) is a progressive, chronic, irreversible, and incurable brain condition characterized by declining cognitive ability and increasing functional disability [Although the pathophysiological mechanism of AD is complex and not yet fully understood, its pathological features are principally attributed to the deposition of extracellular amyloid beta (Aβ) peptide that constitutes senile plaques (SP), formation of tau protein-associated neurofibrillary tangles (NFTs), and loss of synapses [Some studies have shown that microglia play an important role in the pathogenesis of AD by releasing inflammatory mediators such as inflammatory cytokines, complement, chemokines, and free radicals [Taking this into account, the Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, and the South China Center for Innovative Pharmaceuticals collaboratively developed a new neuroinflammation inhibitor AD16, also known as (2-pyrimidinepiperazinyl)-(4-methyl-6-phenylpyridazine)-methanone (Fig. Chemical structure of AD16The present study aimed to assess the pharmacokinetics (PK), safety, and tolerability of AD16 in healthy Chinese adults after single and multiple ascending doses. Moreover, the effect of a high-fat diet on the PK parameters of AD16 was investigated.