2.5. Statistical Analysis
REGRESSION
Demographic and baseline participant characteristic data are displayed as the mean ± SD or number (%). We aimed to investigate the effects of curcumin supplementation for four weeks on a panel of circulating cytokines compared to the placebo. Initially, we examined histograms of cytokine concentrations and applied log transformations to reduce skewness prior to further analyses. Additionally, cytokine concentrations below the limit of assay detection were replaced with the lowest detected value of the marker divided by 5. A series of linear regression models was used to examine the between-group differences in post-trial biomarker concentrations, controlling for baseline and covariates including age, sex, race/ethnicity, and interval between COVID-19 diagnosis and study enrollment. A nominal 