Limitations
cancer
REGRESSION, CANCER, SECONDARY
Although the findings from the current study are significant, important limitations should be noted. Despite the strengths of baseline and supplemental information, including detailed BMI information at different ages and extended follow-up with linked participant outcomes, the current study is a secondary analysis of a completed cancer screening trial; therefore, the collection of exposure and outcome information was not included as part of the original study. Additionally, all BQ and SQ information was collected by self-report, which includes height and weight data used to calculate BMI. Therefore, aspirin dosing information was not collected as part of the BQ and was not accounted for in this analysis. In addition, we were unable to correlate changes in BMI with aspirin use. Aspirin use, as stated in the BQ and SQ, was reported during the last year, whereas BMI could have changed at any point before the questionnaires. However, in the current analysis, we were only evaluating the association between these 2 factors, not causation. Finally, it is possible that not all confounders were accounted for in our multivariable logistic regression models.