Background
malaria, deaths, death, infections
MALARIA, DISEASE, INFECTIONS, MALARIA
Despite efforts to control and eliminate malaria, it remains a major public health concern in sub-Saharan Africa (SSA). As documented in successive editions of the World Malaria Report, malaria continues to cause unacceptably high levels of disease and death in sub-Saharan Africa. According to the 2021 World Health Organization (WHO) malaria report, there were an estimated 241 million malaria cases and 627,000 malaria deaths in 2020, representing about 14 million more cases in 2020 compared to 2019 and 69,000 more deaths [Since the first report of reduced in vivo susceptibility in the late 2000s, the prevalence of drug-resistant infections has increased and spread to other parts of Southeast Asia and the rest of the world [Artemether–lumefantrine (AL), the most used treatment for uncomplicated malaria in several African countries, including Nigeria, has an impressive safety and efficacy record [Pyronaridine–artesunate [Pyramax™; Shin-Poong Pharma Ltd., South Korea] first received a positive scientific opinion from the European Medicines Agency under Article 58 for the tablet formulation in 2012. Pyramax™ granules (a special paediatric formulation] were subsequently granted a positive scientific opinion through Article 58 in 2015 [Furthermore, Sowunmi et al. [