PLA formation
The mean (range) TRAP-activated baseline pre-dose PLA formation was 39% (29–47%) and 33% (19–46%) for cohorts 1 and 2, respectively. After administration of a single IV dose of inclacumab, mean TRAP-activated PLA formation decreased rapidly to 14% (11–16%) for cohort 1 and 9% (6–11%) for cohort 2 within 3 h from the start of the approximately 1-h infusion (Fig. 