Limitations
malocclusion
BLIND
The current RCT has some limitations. First, the Hawthorne effect and detection bias are possible to happen due to the inability to blind both patients and the principal researcher. Secondly, lack of previous well designed trials led to the impossibility of direct comparison regarding the guide accuracy. Finally, mensuration of efficacy and accuracy outcomes using other acceleration methods in different malocclusion cases is recommended in forthcoming research.