Introduction
pain
INFLAMMATORY RESPONSES, CORNEA
The cornea is one of the most densely innervated structures in the human body, with a dense subepithelial plexus in the anterior third of the stroma and sensory afferent neurons that send painful stimuli to the central nervous system (CNS).Transient receptor potential cation channel subfamily V member 1 (TRPV1) is a key nociceptor in corneal tissues that has a dual function in pain sensing, transmission, and regulation, as well as mediating innate inflammatory responses.