Background
multiple organ failure, death, Sepsis, infection, septic shock, systemic derangements
VASODILATION, MULTIPLE ORGAN FAILURE, SEPSIS, INFECTION, SEPTIC SHOCK, ENDOTHELIAL DYSFUNCTION
Sepsis is a host’s dysregulated response to an infection, characterized by endothelial dysfunction leading to increased vascular permeability, abnormal nitric oxide (NO) metabolism, vasodilation, among other systemic derangements [Methylene blue (MB) is a specific inhibitor of the inducible nitric oxide synthase (iNOS) and its downstream enzyme soluble guanylate cyclase (sGC). Through its indirect pressor effects, it has been shown to restore vasoregulation in conditions of NO upregulation [Based on large datasets, it is increasingly recognized that a higher exposure to catecholamine vasopressors is associated with an increased risk of multiple organ failure and death in septic shock [