1. Introduction
Biofilm-induced gingivitis, gingivitis
DISEASE, DISEASES, GINGIVITIS, PATHOGENESIS
The present study aims to test whether probiotics protect against experimental gingivitis incited by 14 days of oral hygiene neglect and/or subsequently support the restoration of oral homeostasis. Eighty systemically and orally healthy participants refrained from oral hygiene procedures for 14 days, followed by 14 days with regular oral hygiene procedures. Additionally, participants consumed either probiotics (Biofilm-induced gingivitis, here referred to as gingivitis, is among the most prevalent diseases worldwide, affecting up to 90% of the population [Since 1965, the experimental gingivitis model has been extensively used for studies on the pathogenesis of the disease [Recently, we demonstrated that the consumption of probiotic lozenges containing In a randomized, double-blinded, clinical trial, we, therefore, tested the hypothesis that supplementary use of probiotics protects the supragingival microbiota in healthy individuals against biofilm-induced gingivitis caused by a 14-day absence of oral hygiene procedures and that probiotics support the resilience of the supragingival microbiota in the resolution period, i.e., the 14 days after oral hygiene procedures are resumed. Specifically, we aimed to test whether the combination of 