Implications of universal testing
For breast patients over 45 or 50 years, the current indications for the gBRCA testing based on several clinical characteristics or family history as recommended by different guidelines may have limitations [For gBRCA-mutant BC, bilateral mastectomy might be preferable over breast-conserving surgery at the initial surgery consideration [Complex guidelines and malpractice by oncologists may somehow affect the practice of current gBRCA screening policies [