Conclusions
IBD
DISEASE, RECURRENCE
We identify methylation changes present at the time of surgery that are associated with future CD recurrence within 3 years. Probes within the 5 site-specific (DMPs) and 5 DVPs associate with the underlying genotype and relate to genes with biologic relevance to CD. Given the relationship between smoking, methylation, and IBD, we have identified CD-specific smoking-related methylation sites. Replication of the CD-associated methylation alterations is achieved, having previously characterized only in adult and pediatric inception cohorts, in patients with well-established disease requiring surgery.