4. Discussion
cancer, CRC
PROLIFERATION, CANCER
In this post hoc analysis of the AMATERASU trial [While sCD40L has been the subject of investigation in various medical contexts, including cognitive aging [Moreover, our discussion regarding the effects of vitamin D supplementation in specific subgroups highlights the potential of vitamin D in improving the prognosis of CRC patients with elevated sCD40L levels. Additionally, compelling literature evidence suggests that sCD40L might contribute to the immunosuppression observed in cancer patients. This might occur through various mechanisms, including sCD40L-enriched myeloid-derived suppressor cells, an additive inhibitory effect on T-cell proliferation, greater sCD40L-induced enrichment of PD-1 expressing T cells, and inhibition of IL-12 production from monocytes [