Methods
SICH
INTRACRANIAL HEMORRHAGE
The study design was a randomized (3 active: 1 sham), sham-controlled, 3 + 3 dose-escalation clinical trial (protocol available in A total of 6 dose tiers were initially planned, increasing in intensity or duration of stimulation. The occurrence of symptomatic intracranial hemorrhage (SICH) determined the escalation pace through the tiers (eMethods in HD C-tDCS was delivered to the ischemic tissue using individualized montages. Six HD montages were predesigned to cover 6 vascular distribution-specific ischemic fields caused by occlusions of the middle cerebral artery (MCA) trunk, MCA superior division, MCA inferior division, posterior cerebral artery, anterior cerebral artery, and posterior inferior cerebellar artery. The coverage of ischemic regions by electric fields was estimated via computational modeling of the electrical current flow (