Introduction
Microbial communities in the colon have a profound effect on host physiology, including immune function, inter-organ communication, and metabolismThe effect of the gut microbiome on weight regulation has been a topic of high interestTo address these critical knowledge gaps, here we describe the results of the intersection of host-diet-gut microbiome factors on human energy balance generated by performing a controlled feeding study in a metabolic ward using a deep-phenotyping paradigm of quantitative bioenergetics (NCT02939703)