Introduction
later neurologic impairment
BRONCHOPULMONARY DYSPLASIA (BPD)
Invasive mechanical ventilation (IMV) is a life-saving intervention for preterm neonates but is associated with negative outcomes, such as bronchopulmonary dysplasia (BPD) and later neurologic impairment.The NASONE (Nasal Oscillation Post-Extubation) study was a multicenter, assessor-blinded, randomized clinical trial investigating, from primary extubation until discharge from the neonatal intensive care unit (NICU), the use of noninvasive high-frequency oscillatory ventilation (NHFOV) vs nasal continuous positive airway pressure (NCPAP) vs unsynchronized noninvasive intermittent positive pressure ventilation (NIPPV) to reduce the duration of IMV.Clinical algorithms integrating respiratory support have been proposed to personalize the assistance of extremely preterm neonates, but we need evidence-based data to refine them.