2.2. Rodent Model
Characteristics of the rodent model have been described in detail previously [Further analysis of these metabolites (2 acylcarnitines, 6 amino acids, 2 biogenic amine, 3 lysoPCs, 41 PCs and 8 sphingolipids) with PCA showed that the first two components explained 74% of the variance. PC1 was mainly characterized by phosphatidylcholines. PC2 was not characterized by a specific subgroup of metabolites (see We performed hierarchical clustering of the 62 metabolites with significant differences between the RYGB_rat and the BWM_rat group (see 