Endpoints and assessment
death
DISEASE, DISEASE PROGRESSION, SECONDARY
The major endpoint was the objective response rate (ORR), which was determined by the investigators as the percentage of patients who had a complete response (CR) or a partial response (PR) according to RECIST version 1.1.The secondary endpoints were: Progression-free survival (PFS), defined as the interval between treatment initiation and the date of the disease progression or death from any cause); overall survival (OS), defined as the interval between treatment initiation and the date of death from any cause; the disease control rate (DCR), defined as the percentage of patients with stable disease, PR, or CR; and safety.