Results
DOWN SYNDROME
Among 235 pregnant women who were approached, 49 did not meet the inclusion criteria and 10 declined to participate, leaving 176 to be enrolled in the study. They were randomized into either the video or non-video groups. According to the principles of “intention to treat analysis”, participants are not to be excluded when they do not complete the intervention. However, in case of missing data regarding the outcome, they would be excluded. (five participants from the video group and six from the non-video group). The CONSORT diagram of the study is shown in Fig. CONSORT 2010 flow diagram for ‘Effects of an animated educational video on knowledge of cell-free DNA screening among pregnant women: a randomized control trial’Both groups had comparable demographic data. The educational levels of the counselors and the time between the pre- and post-counseling test were not significantly different between the two groups (Table Demographic data of participants in the video and non-video groupscf., cell-free; MFM, maternal–fetal medicine; OBGYN, obstetrics and gynecologyThe mean ± SD knowledge scores in the two groups before counseling were comparable: 7.4 ± 3.1 in the video group vs 7.3 ± 3.2 for the non-video group (Comparison of knowledge scores between the video and non-video group.* Before counseling, a similar percentage of the participants in each group had correct knowledge about fetal conditions that could be detected via cell-free DNA screening. After counseling, the percentage of participants with the correct knowledge was significantly increased in both groups (Comparison of pregnant women’s knowledge about fetal conditions detected by cell free- DNA screening, between groups.* The two groups, at baseline, showed comparable percentage of participants who knew about the performance and limitations of cell-free DNA screening. After counseling, there was a higher percentage of pregnant women in the video group who understood about false positive rate, limitation of using positive cell-free DNA screening for the decision of termination of pregnancy, possibility of false negative screening for Down syndrome, and avoidance of cell-free DNA screening in individuals with recent blood transfusion (Table Comparison of pregnant women’s knowledge about performance and limitations of cell-free DNA screening, between groups.Cf, cell-free*In both groups, there was no statistically significant difference in concern about positive cell-free DNA screening before counseling, as well as after the counseling (Comparison of attitude toward receiving a positive result and counseling satisfaction level, between groups