Item-level analyses
Item-level analyses and the distribution of ADCS-ADL-MCI total scores for the full sample and by sex at baseline and month 36 are shown in Supplemental Tables At baseline, about two-thirds of individual items exhibited ceiling effects, i.e., a generally high level of ability of most patients regarding ADLs. Specifically, items 1, 2, 3, 10, 11, 12a-c, 13a, 14a, 15a-b, 16a-c, 17a, and 18a had strong ceiling effects, with over 80% of subjects being assessed as carrying out the respective activity "without supervision". Likewise, at month 36, most of these ceiling effects at the item level remained but to a lesser extent (i.e., no longer evident for items 1, 10 and 11). Further, some differences were observed by sex for specific items, such that a lower proportion of males were endorsed in the first step of the gating question. This finding applied to items assessing cleaning or loading laundry; for example, 67% of males versus 88% of females were evaluated as having cleaned (item 4), and 45% of males versus 96% of females were assessed as having loaded laundry (item 7) in the past four weeks. Similar differences by sex were observed at month 36.At the total ADCS-ADL-MCI score level, the observed ceiling effects at baseline and month 36 were no longer apparent. With a maximum possible total score of 53, less than 3% of patients reached the top score, while less than 15% reached one of the top three scores at baseline (i.e., reached a score ≥ 51). The overall distribution of scores at baseline was mean (standard deviation, SD) = 45.95 (4.77) and median (interquartile range, IQR) = 47 (44–49.5). Similarly, less than 1% of patients reached the top score, and less than 13% reached one of the top three scores at month 36 (i.e., reached a score ≥ 51). The overall distribution of scores at month 36 was mean (SD) = 40.63 (10.97) and median (IQR) = 45 (35, 49).