1. Introduction
uremic myopathy, alteration affecting skeletal muscles, ESKD
METABOLIC ACIDOSIS, UREMIC MYOPATHY, CHRONIC KIDNEY DISEASE (CKD)
Chronic kidney disease (CKD) is responsible for a progressive alteration affecting skeletal muscles with a multifactorial etiology, including myocellular, immunologic and hormonal changes, metabolic acidosis, reduced protein intake and physical inactivity [This condition, known as uremic myopathy, affects approximately 50% of patients on dialysis [Uremic myopathy is favorably counteracted by physical activity, both aerobic and anaerobic, which has been proven to be safe in patients on hemodialysis [However, to fight the decline in respiratory function, several training protocols specific for respiratory muscles have been developed [The aim of this pilot randomised controlled trial was to determine the feasibility and effectiveness of home-based low-intensity RMT on respiratory muscle strength and lung function using a positive pressure and volume exerciser device in ESKD patients.