Methods
This clinical trial has been registered at ClinicalTrials.gov, number NCT04140123.This study and all amendments have been approved by the institutional review board or independent ethics committee of each study center [the First Hospital of Jilin University (Changchun, China), Nafang Hospital, Nanfang Medical University (Guangzhou, China) and Beijing Friendship Hospital, Capital Medical University (Beijing, China); approval numbers: 19Y110-007, NFEC-201909-Y4, 2019-PI-036-04]. All procedures were performed in accordance with the principles of the Declaration of Helsinki and Good Clinical Practice. Prior to the trial entry, all participants provided written informed consent.