Introduction
euthyroidism, hypothyroidism
HYPOTHYROIDISM
Levothyroxine monotherapy is considered the standard of care for hypothyroidism by professional organizations, whereby the patients achieve the state of euthyroidism through the normalization of TSH, a reliable proxy of euthyroidism [Clinically, a sizable minority of patients adequately treated with LT4 complain of residual symptoms [The above-mentioned evidence led to the growing interest in combination therapy with LT4 plus liothyronine(LT3); however, multiple randomized controlled clinical trials addressing objective and subjective clinical outcomes did not provide conclusive results [To design clinical trials with a greater likelihood of indicating efficacy, the American, European, and British thyroid associations have recently published a consensus statement to promote the development of future clinical trials [