Interventions
Participants were allocated to ISMN (40-60 mg/d; typical UK hospital formulations), cilostazol (200 mg/d), ISMN-cilostazol (40-60 and 200 mg/d, respectively), or no study drug, dispensed by site hospital pharmacies. Participants started their allocated drug(s) the day after randomization at a low dose, escalating to the full or maximum tolerated dose by 4 weeks, as developed in the LACI-1 trial.