Effect of icatibant on bradykinin concentrations
hypotension, intradialytic hypotension
INTRADIALYTIC HYPOTENSION
Bradykinin concentrations were measured prior to, at the beginning of hemodialysis, at 30, and 60 min after initiation of hemodialysis. There was no effect of icatibant versus placebo on bradykinin levels during hemodialysis. In addition, patients who experienced intradialytic hypotension had similar bradykinin levels compared to patients who did not experience hypotension [80.9 (37.5, 104.8) vs. 85.9 (45.0, 155.1) fmol/ml, median (interquartile range), at 30 min, p = 0.66].