Interim analyses
infection
INFECTION
The objective of interim analyses will be to determine if there exist profiles of patients with specific characteristics, to assess if the interventions act differently according to subgroup. We hypothesize a subdivision of patients according to the presence of a more cognitive or psychological profile. For this Latent Profile Analysis (LPA), the z-standardized mean scale scores of the following variables will be entered in the model: composite scores for memory, attention and executive performance, global score at OCQ and M-FIS. All this continuous variables will be used If the presence of these two sub-groups is confirmed, we will next assess if they differ on primary outcomes (complaints at BRIEF and MMQ scales), quality of life (ISQV), medical variables (length of potential hospitalization; presence and duration of ventilation; presence of neurological symptoms at acute phase time since infection), presence/absence of antecedent psychological difficulties, age and sex.