Introduction
migraine, Migraine
MIGRAINE, DISEASE, MIGRAINE
Migraine is a highly prevalent disease affecting more than 1 billion people worldwide.A key feature of migraine is that various environmental and endogenous trigger factors can initiate an attack.Thus, it is timely to ascertain whether migraine attack generation requires CGRP receptor activation. This can be established through the use of human provocation models. We hypothesized that treatment with erenumab would mitigate the physiological effects of administration of CGRP, but not those of cilostazol. To test this hypothesis, we conducted a randomized, double-blind, placebo-controlled, parallel trial.