Safety evaluation
bradyarrhythmia, cardiac complications
ADVERSE EVENTS, EVENT, BRADYARRHYTHMIA, CARDIAC COMPLICATIONS
Neither cardiac complications nor other serious adverse events occurred. A single patient in the treatment arm had a temporary asymptomatic junctional bradyarrhythmia that required no intervention, and the study drug was continued. This event was noted, and the patient remained in the study. No patients were removed from the study due to safety concerns. Study drug was never held due to concerns over clinical care. Non-study propranolol or clonidine were never required by clinical personnel in the ICU during the treatment period.