4.1 Amino acid metabolism
PROLIFERATION, CAVITY, UTERUS
Female fertility has a great relationship with the internal environment of the uterus, and hormonal changes can cause changes in the uterus, which are essential for uterine receptivity as well as for embryonic development and implantation. In the first two weeks of embryo transfer, conception of the fetus depends entirely on the intrauterine environment created by endometrial secretions or molecules entering the uterine cavity before implantation and placenta (Changes in the endocrine environment before and after ovulation have been found to affect amino acid transport from maternal circulation to endometrial cells and finally to the uterine cavity through expression of the AA transporter pathway, and concentrations of taurine, alanine, and α-aminobutyric acid are higher in uterine cavity washings on day 4 after ovulation, which represents a hyporeceptive uterus in this animal model (Differential metabolites in amino acid metabolism pathways also play a role in ovarian development. Arginine, as a precursor of nitric oxide, polyamines and creatine synthesis, has different physiological functions. Most metabolites in the arginine metabolism pathway increased from stage II to stage III, including arginine, proline, γ-aminobutyric acid-related metabolites, and creatine related metabolites, suggesting that enhanced arginine metabolism is a biomarker for stage III ovaries and is used to control cell proliferation and differentiation during early ovarian development. In addition, as a cellular energy shuttle (phosphocreatine can regenerate ATP), creatine plays a critical role in regulating energy metabolism and may be a metabolic response to the high energy requirements of the developing ovary (Amino acids act in various ways as organic osmotic cells, intracellular buffers, heavy metal chelators and energy substrates (