Mendelian randomization analysis
PD, MR, cardio-cerebrovascular diseases
To determine whether there is a causal association between PD and cardio-cerebrovascular diseases, we mostly employ the inverse variance weighted (IVW) approach for MR analysis. An IVW estimate is a measure of the combined overall effect size of Wald ratio estimates for individual SNPs. The IVW method is highly effective and reliable when all the SNPs included in the analysis are valid and uncorrelated