Introduction
inferior alveolar nerve block, postoperative pain
COLD
The inferior alveolar nerve block (IANB) is the routine and standard technique used to obtain pulpal anesthesia of the mandibular quadrant [According to reports, the IANB success rate ranged from 10 to 75% [Cold application is a well-known approach for postoperative pain management in medicine [Very limited data was available regarding the effectiveness of IANB after cryotherapy application in patients with SIP. The available data was limited to patients over 18 years. Therefore, the primary aim of this trial was to assess the effectiveness of cryotherapy application after IANB injection of the mandibular first permanent molars with SIP in adolescents (i.e., the null hypothesis (