Main findings
septic shock
INFLAMMATION, SEPTIC SHOCK
In this double-blind, randomized, controlled study in septic shock patients, we compared the physiological effects of a single 60-g dose of NaAscorbate infused over 6 h with placebo. We found that the difference in total 24-h urine output was not statistically different. However, NaAscorbate induced a greater cumulative increase in urine output over time. Moreover, it led to a greater decrease in vasopressor dose and SOFA score over time. Finally, we showed a dramatic effect on plasma ascorbate levels but no significant effect on biomarkers of inflammation.