1. Introduction
cognitive impairments
NEURODEGENERATIVE DISEASES
The aim of this study was to assess the effects of guayusa extract and Nordic Lion’s Mane (LM) on cognition. Using a randomized, double-blind, placebo-controlled, crossover design, we examined the effects of a single dose of 650 mg guayusa extract (AMT: AmaTeaGuayusa (guayusa extract) is a naturally occurring tea currently available as a GRAS food ingredient. AmaTeaThe Nordic Lion’s Mane (The majority of studies on LM thus far have investigated its effects in regard to subjects with cognitive impairments and have shown benefits towards neurodegenerative diseases [In a rat model, erinacines have upregulated NGF levels in the hippocampus (where memory formation and spatial navigation take place) and the locus coeruleus (a small portion of the brainstem that plays a role in the regulation of arousal and attention) [Given the dearth of scientific investigations examining both guayusa and LM on acute cognitive performance in healthy adults, this study aimed to assess the effects of AMT and LM on objective cognitive performance and subjective cognitive perception, including mental clarity, mood, focus, concentration, productivity, anxiety/stress, and happiness.