Statistics
REGRESSION
Values are summarized as mean and standard deviation or as median and interquartile range as appropriate. Students t-test or the Kruskal Wallis test were used to compare continuous data. Data was fitted using mixed-effect linear regression models with random intercepts and patient ID as random effect to test the primary hypothesis. A Bland-Altman plot was used to interpret comparability of the two baseline TBK measurements. The assumption of normal distribution of model residuals was tested by Shapiro-Wilk test. For changes in p-K the W statistic was 0.97, P = 0.39 and for TBK the W statistic was 0.96, P = 0.11. Analyses were carried out using standard statistical software (R version 4.1.0).