Conclusion
opioid dependence, fatigue, anxiety, Pain, cancer, FM, ALS, pain, depression
CHRONIC PAIN, EVENTS, CANCER
Pain intensity did not significantly differ between VR and MEOPA arms during bone marrow biopsy in this study. The VR-based distraction method was safe and appreciated by patients and caregivers. Digital therapeutics could be an alternative treatment in case of contraindication or intolerance to MEOPA and could be integrated into the oncology support care panel.Further studies should focus on demonstrating the efficacy of a VR program (content, type, interactions, number of sessions, program duration) in pain prevention and other symptoms (fatigue, depression, anxiety, cognitive functions) for each indication, compared with conventional drugs with a noninferiority outcome, if possible, and based on feasible objective parameters. The impact of VR will also have to be studied for patients hospitalized for a long period of time and at home for outpatients. For chronic pain, VR should be evaluated in terms of scheduling, efficacy, and tolerability to reduce opioid dependence in cancer patients [The authors would like to thank the patients and their families for their participation and Melanie Peron, Etienne Lepoutre, and Magali Balavoine for their intellectual input and advice. This investigation was supported by a grant from the French Lymphome Espoir Association and the Fundings of Hoffman-Roche lab and the Elsan group.The study was supported by Hoffmann-La Roche, the Elsan group, and the France Lymphome Espoir Association.Authors' Contributions: KLD, ALS, and SB designed the study. ALS assembled, analyzed, and interpreted the data. KLD wrote the first draft of the manuscript. All authors were involved in the preparation and revisions of the manuscript and approved the final version of the manuscript for submission.Conflicts of Interest: KLD reports receiving consulting fees from Incyte, Abbvie, and Janssen-Cilag and research support from Roche. FM reports receiving consulting fees from Pfizer, Amgen, Incyte, and Roche. SB is president and part owner of In Virtuo, a company that distributes virtual environments.Bone marrow events.VR tolerance (n=59).Feeling of immersion (n=56).Fear of pain.CONSORT-eHEALTH checklist V 1.6.1.