Pharmacokinetic assessments
BLOOD
Blood samples were collected predose and 0.5, 1, 1.5, 2, 3, 4, 5, 6, 8, 12, 24, 36, and 48 h post dose. In the Oxycodone Study, plasma samples were analyzed for REL-101 and oxycodone. In the Ketamine Study, plasma samples were analyzed for esmethadone, ketamine, norketamine, DXM, and dextrorphan.