CONCLUSIONS AND FUTURE PERSPECTIVES
inflammation, breast cancer
METASTASIS, BREAST CANCER, INFLAMMATION, DISEASE, NODE-POSITIVE BREAST CANCER, TUMORIGENESIS
The preoperative hydroxyprogesterone administration improves disease-free and overall survival in patients with node-positive breast cancer. The mechanism behind this improvement is thought to be related to the modulation of cellular stress response and the negative regulation of inflammation through the upregulation of the kinase gene Our findings highlight the complex genomic and molecular mechanisms involved in the response to progesterone in breast cancer and the potential for non-coding RNAs to play a regulatory role in this process. The mechanisms underlying the observed effects of progesterone on breast cancer outcomes are unclear. However, progesterone may modulate the expression of genes involved in tumorigenesis and metastasis, as well as affect the expression and genomic activity of ER and other factors that play a critical role in breast cancer development and progression. Further studies are needed to elucidate the precise mechanisms by which progesterone influences breast cancer outcomes. This information may help in the development of novel treatment and diagnostic strategies to overcome this disease.Overall, while preoperative hydroxyprogesterone administration appears to be a promising strategy for improving the prognosis of patients with node-positive breast cancer, the investigation of the mechanism of actions of progesterone in breast cancer remains an important area of research that holds great promise for improving patient outcomes.