Measurements and data collection
TBI, Coma, brain injury, traumatic brain injury
COMA
Airway pressure and flow (pneumotachograph) were measured proximal to the endotracheal tube. Oesophageal pressure was measured by using an oesophageal balloon catheter (BA-A-008, MBMed, Argentina). Airway and oesophageal pressures and airflow signals were recorded with FluxView software on a computer connected to a respiratory monitor (FluxMed GrT®, MBMed, Argentina). TPP was calculated as the difference between airway and oesophageal pressures, as described by others [Intensive care monitoring software (ICM + ®, Cambridge Enterprise Ltd, Cambridge UK) [Additionally, the following demographic and clinical data were retrieved from the medical records of the patients: age, sex, BMI, predicted body weight (PBW), Glasgow Coma Scale (GCS), type of brain injury, severity of traumatic brain injury (TBI) by Marshall classification [