1. Introduction
obesity, diabetes
OBESITY, HYPERTENSION, DIABETES
The primary objective of this randomized trial was to test the effectiveness of the PREDHiCT digital application, which provides educational and supportive navigation to increase willingness to participate in a future clinical trial. The second objective was to test whether PREDHiCT increased clinical trial literacy or enhanced psychological facilitators of clinical trial participation, such as altruism. To test these two objectives, we conducted a 1-month remote decentralized trial with 100 participants who either have a personal or family history of cardiometabolic health conditions, such as hypertension, diabetes, and obesity. Results indicated significant changes in altruism (mean: −2.94 vs. 0.83; The FDA recently revealed that almost half of clinical trials failed to include sufficient representation of racial/ethnic minorities and low income individuals [In the ongoing pursuit of addressing the persistent issue of underrepresentation in clinical trials, the role of education and navigation solutions has gained increasing attention. Historically, clinical trials have struggled to recruit a diverse participant pool, leading to concerns about the generalizability of research findings. Education and navigation solutions have emerged as valuable tools for dismantling barriers that historically deter individuals from underrepresented backgrounds. The strength of these solutions lies in their potential to provide accessible information and support, helping individuals overcome challenges such as limited awareness, mistrust, and logistical barriers. However, their weakness lies in a lack of precision and personalization. Standardized education and navigation approaches may not adequately address the unique needs and concerns of each potential participant. Additionally, while these solutions can mitigate certain barriers, they may not fully overcome the geographical and logistical challenges that can make participation difficult. 