3.3. Secondary outcomes
AKI, postoperative nausea and vomiting, hypotension, PONV, acute kidney injury
REGRESSION
The number of patients with an HR < 50 bpm after the DEX loading dose infusion was significantly higher in the DEX group than in the DEX-NCD group at 12, 16, 24, 26, and 30 minutes after DEX administration (Fig. Univariable and multivariable logistic regression analysis of factors associated with an HR < 50 beats per min after nicardipine infusion.ASA = American Society of Anesthesiologists, BMI = body mass index, CI = confidence interval, DEX-NCD = dexmedetomidine-nicardipine, HR = heart rate, mBP = mean blood pressure, OR = odds ratio.Statistical significance.The number of patients with HR < 50 beats per min during the perioperative period. The gray zone is the period of nicardipine infusion in the DEX-NCD group. *Significant differences between the 2 groups at each time point. DEX = dexmedetomidine, DEX-NCD = dexmedetomidine-nicardipine, HR = heart rate, PACU = postanesthesia care unit.Forest plot of the odds ratios for an HR < 50 beats per min after nicardipine infusion. BMI = body mass index, DEX-NCD = dexmedetomidine-nicardipine, HR = heart rate.Postoperative outcomes such as hypotension and LOS in the PACU were not significantly different between the 2 groups. PONV, POUR, time to first urination after SA, and postoperative creatinine levels were also comparable between the groups. AKI did not occur in either group until POD 2, and there was no significant difference in the postoperative hospital LOS between the 2 groups (Table Postoperative data of the study cohort.Data are presented as medians (interquartile ranges) or numbers (%).AKI = acute kidney injury, DEX = dexmedetomidine, DEX-NCD = dexmedetomidine-nicardipine, LOS = length of stay, PACU = postanesthesia care unit, POD = postoperative days, PONV = postoperative nausea and vomiting, SA = spinal anesthesia.