Objective 1: Willingness and ability to recruit eligible patients
SDD-enhanced infection
RECRUITMENT
Between 19 September 2021 and 13 February 2022, 539 children were screened for inclusion into the baseline and intervention phases of the trial (Periods one and two), of which 433 (80.3%) were eligible and 368 (84.9%) of these were enrolled (Fig. shows cumulative recruitment in the two periods of the study (period 1, left and 2, right). The top panels show actual (orange) versus anticipated (green) enrolment. The bottom panels show enrolment in each period based on the unit randomisation in period 2 (standard care, green; SDD-enhanced infection control, orange).This was higher than the pre-trial expected recruitment of 306 children across the course of Periods One and Two. In the three ecology weeks a total of 233 children were screened, 223 (95.7%) eligible and 191 (85.6%) were enrolled.Issues with eligible children being missed were due to difficulties in staff knowing whether children would be ventilated for 48 h, as per inclusion criteria: 