Statistical analysis
SD
An independent t-test, Fisher’s Exact test, and Chi-square test were used for demographic data, presented as mean ± SD, and percentage. Repeated ANOVA was used to compare the mean of quantitative variables over time. The Chi-square test was used to assess failure of treatment. The p value < 0.05 was considered statistically significant. Data were analyzed with STATA 17. All study parameters were analyzed according to the intention-to-treat (ITT) principle.