Data collection and conventions for key data
ADVERSE EVENTS
Data were collected, entered and managed by the CCTG, according to the group standard data management procedures. A clinical data cutoff point was set once the 50th patient enrolled to the trial had been followed for 12 weeks and ctDNA molecular response and radiographic response had been determined. The clinical trial database was cleaned and locked on 20 September 2022. Baseline study evaluations were defined as those collected closest to and before or on the first day of study medication for study participants. The collection timepoints of samples analyzed for ctDNA molecular response were determined by collection date rather than the treatment cycle, as some cycles were delayed due to adverse events.