24HC levels
In participants receiving soticlestat, mean plasma 24HC levels decreased by approximately 70% in the first 2 weeks of treatment and remained at reduced levels throughout study parts A and B (Mean plasma 24HC levels (pharmacodynamic analysis set). 24HC = 24S-hydroxycholesterol; SD = standard deviation. One participant who received soticlestat 100 mg and had baseline measurement only has not been included. 