Longitudinal analysis
ideation, suicidal ideation
Repeated measures analysis of variance with KP as dependent variable and study arm (minocycline/placebo) and baseline suicidality (ideation present/absent) as factors. For this analysis, we log transformed KP variables to normalize their distribution. With a chi-square test, we explored differences in the proportion of patients with suicidal ideation between minocycline and placebo at baseline and week 4. Inflammatory cytokines were log transformed before conducting the analysis. Analyses were conducted on IBM SPSS Statistics version 26 (Armonk, NY, USA).