Materials and methods
REGRESSION, RECRUITMENT
The full method for this study, power calculations, assessment selection and analysis plan are outlined in the protocol paper [The Scottish MND Register (Clinical Audit Research and Evaluation of MND–CARE–MND) has a strong history of high case ascertainment associated with longitudinal clinical phenotyping, collating many of the clinical variables included in this study. CARE–MND is also a register of people with MND who are interested in research participation and was used to facilitate recruitment [Data requests to CARE–MND and MND–SMART for information relating to physical functioning, cognition and clinical phenotype enabled a reduction in in burden for participants by ensuring brevity in study visits. Data on MND–SMART participation was requested a minimum of 12 months after study questionnaires were completed. This study recruited 120 individuals with a diagnosis of MND. The sample size calculation was based upon the use of a logistical regression model, recruitment to MND–SMART clinical trial is a binary outcome variable (Yes/No to participation). An OR (measure of association between an exposure and an outcome) of 1.70 with power at 0.70 provided a sample size estimate of 111.