Materials and methods
comorbid inherited metabolic diseases, allergies, traumatic, trauma
ALLERGIES
This study was approved by the Medical Ethics Committee of Hunan Children’s Hospital (HCHLL-2022–079) and registered with the Chinese Clinical Trial Registry (Registration number: ChiCTR2200063144, Date of Registration: 31/08/2022). All experiments were conducted in compliance with the Declaration of Helsinki and relevant guidelines.Children aged 3–12 years, who had a normal preoperative examination, no history of surgery or trauma, BMI ≤ 20, and an ASA class I–II, were selected to sign an informed consent form prior to undergoing daytime adenotonsillectomy at our hospital. The exclusion criteria included a history of traumatic surgery or allergies, abnormal preoperative findings, comorbid inherited metabolic diseases, and altered surgical procedures.Children were randomly divided into the C4, C6, and C8 groups, and were respectively injected with ciprofol at doses of 0.4 mg/kg, 0.6 mg/kg, and 0.8 mg/kg during the induction. Our study employed double-blinding. After the parents of the children have signed the informed consent form, the investigator will open their randomization envelope and assign the child to the corresponding group. At the same time, the investigator handed the pre-prepared induction medication to the anesthesiologist in charge of the surgery. The medication, ciprofol, is contained in a syringe with an obscured barrel, making the volume of the medication not visible to the anesthesiologist. Assessment of endotracheal intubation and intubation conditions was conducted by an experienced anesthetist with over 5 years of expertise in pediatric anesthesia. This individual was also responsible for documenting vital signs. Children, their parents, and anesthesiologists were blinded to group allocation.