Study setting
AFRICAN TRYPANOSOMIASIS
In Guinea, clinical suspects were prospectively recruited for the Diagnostic tools for human African trypanosomiasis elimination and clinical trials work package 2 (DiTECT-HAT-WP2) study between January 2017 and January 2020 in 14 hospitals and health posts in the prefectures of Boffa, Dubreka and Forecariah. In these 3 prefectures, the HAT prevalence expressed as number of HAT cases per 10,000 inhabitants in 2017 was respectively 2.92, 0.53 and 1.51, and decreased to 0.97, 0.33 and 0.99 in 2019 [The initial sample size estimation was based on 13 health structures, performing RDTs on 15 clinical suspects each month, for 27 months, which would have resulted in 5265 inclusions. We estimated that in about 10% of the clinical suspects tested, at least one RDT would be positive. The HAT prevalence among clinical suspects was estimated at 1%, which would result in inclusion of 53 HAT patients.