Introduction
toxicity, necrosis
PRIMARY TUMORS, RECURRENT DISEASE, REMISSION, MEDULLOBLASTOMA, NECROSIS
Curative treatment options for patients with recurrent primary tumors of the central nervous system (CNS) are limited. Many patients have had previous multimodality therapy, including external beam radiotherapy (EBRT), which introduces the potential for toxicity with additional treatments. For instance, radiation necrosis is a potential toxicity with an incidence of up to 5% [For medulloblastoma, 131-I-3F8 has been shown to be safe and may have clinical utility in maintaining remission in high-risk or recurrent disease [