PRECIS rating procedures
Previously published PRECIS-2 and PRECIS-2-PS manuscripts and tool descriptions informed the rating procedures [The PRECIS raters included seven study team members at the University of Washington’s Harborview Medical Center (DZ, LW, KM, AE, LP, JR, JW). The raters volunteered to participate on the project and were recruited based on their availability and interest. The raters had varying familiarity with the DO-SBIS and TSOS trials. None of the raters had previously participated in PRECIS-2 coding exercises.All raters received PRECIS-2 and PRECIS-2-PS coding training tailored to the acute care medical context in which the DO-SBIS and TSOS trials were conducted. The training consisted of an initial PowerPoint zoom call orientation with the lead investigator (DZ). The initial presentation reviewed the original PRECIS-2 and PRECIS-2-PS publications as well as previous manuscripts documenting PRECIS coding efforts. The raters were instructed to derive their PRECIS-2 and PRECIS-2-PS ratings from a review of the DO-SBIS and TSOS trials study protocol and main outcome manuscripts [The initial coding effort raised questions for multiple raters regarding PRECIS-2 explanatory-pragmatic continuum domain scaling. A recalibration slide set that added example figures and published manuscripts to better articulate the PRECIS-2 explanatory-pragmatic continuum scaling was therefore developed [