Study design
depressed
MODE is a randomized, parallel, superiority and single blinded controlled trial comparing the effectiveness of two active interventions – high frequency (Flow chart of the studyThis study design will overcome many of the limitations of prior psychotherapy effectiveness studies. It will include an active control condition rather than a mere wait list, thereby controlling for the effects of interpersonal attention and interaction. Randomization and statistical evaluation will be performed by independent teams. Moreover, the active comparator condition, low frequency psychoanalysis, will help to control for the “allegiance” effects that confound most psychotherapy trials [In addition to randomization of depressed patients, we will include a group of healthy control participants (