Microbiome Sub-Study
Tax4Fun2
DISEASE
In the microbiome sub-study, participants’ baseline characteristics were balanced between the intervention and the placebo groups, except for the waist circumference, which was higher in the control group compared to the active treatment arm (The stool analyses employed in this sub-study aimed to identify the differences in microbial composition mediated by the disease and the intervention. To identify the stability of the microbial ecology and changes in the composition affected by the intervention, α diversity metrics on Group A2 versus Group A1 and Group B2 versus Group B1 were applied. Both analyses showed a non-significant uptick in α diversity (The Tax4Fun2 pipeline allowed for the prediction of functional changes based on the differential abundance of the sample groups (