Preclinical study
Studies of the pharmacokinetics of the bimatoprost implant in beagle dogs following a single intracameral administration were conducted at Covance Laboratories (Madison, WI) after approval of the study protocol by the Animal Care and Use Committee. The administration procedure used was described previously.After 3 to 6 months, the animals were euthanized with IV pentobarbital, eyes were enucleated, and ocular tissues and residual implant were collected as described previously.