Healthy subjects
The study was conducted at a single centre. Healthy Chinese individuals aged 18–45 years old, with body mass indexes of 18–28 kg/mThe study was approved by the Research Ethics Board of the First Hospital of Jilin University, Jilin, China. This phase 1a study was performed at the Phase I Clinical Trial Unit of the First Hospital of Jilin University, Changchun, Jilin, China. This study was conducted between 21, June 2017 and 14, July 2018 in accordance with the Declaration of Helsinki and followed the principles of Good Clinical Practice. Written informed consent was obtained from all recruited volunteers. The clinical trial registration number was ChiCTR-IIR-17011570.