Study Design
proteinuria
From November 2020 to December 2022, we enrolled 106 kidney transplant recipients from the Department of Nephrology at Heidelberg University Hospital with 108 clinically indicated biopsies into this prospective single-center study. The study was approved by the ethics committee of the University of Heidelberg and conducted in accordance with the Declaration of Helsinki. Written informed consent was obtained from all study participants. The study is registered in the German Clinical Trials Register (DRKS00023604).Serum creatinine and the estimated glomerular filtration rate (eGFR), proteinuria, donor-specific HLA antibodies (DSA) and non-HLA antibodies, as well as dd-cfDNA were measured the day of biopsy (before biopsy, T0), as well as 7 (TStudy design to evaluate the diagnostic potential of donor-derived cell-free DNA (dd-cfDNA) in kidney transplant recipients with indication biopsy. 