Introduction
sleep disorders, tremor, MoA, fatigueSafinamide, slowness, rigidity, Parkinson’s disease, PD, psychiatric, muscular stiffness, cognitive deterioration, gait impairment
DISEASE, DISORDERS, AUTONOMIC DYSFUNCTION, CHRONIC PAIN, COMPLICATIONS
Parkinson’s disease (PD) is characterized by classical motor features such as slowness of movements, muscular stiffness, tremor and gait impairment. With the progression of the disease some non-motor symptoms appear, such as autonomic dysfunction, psychiatric symptoms, chronic pain, cognitive deterioration, sleep disorders and fatigueSafinamide is a multimodal drug with a unique dual mechanism of action (MoA), dopaminergic and non-dopaminergic, that includes reversible monoamine oxidase-B inhibition and glutamate modulationThe epidemiology and the clinical manifestations of PD are different between genders. Prevalence is higher in men who present more severe rigidity and gait problems, while women have generally a tremor dominant and less severe phenotype, possibly due to the different hormonal levels. Women experience more frequently motor complications and psychiatric disorders, with a significant social impact, while men have often a more rapid motor deterioration. Finally, women have a higher incidence of drug-related adverse eventsThis paper describes the results of new additional analyses in males and females Chinese PD subjects of the XINDI trial.