Safety of PIPAC
diarrhea, abdominal distention, toxicity, toxicities, abdominal pain, anemia, constipation, nausea,
ADVERSE EVENT, SURGICAL COMPLICATIONS, ANEMIA
There were no surgical complications by Clavien–Dindo classification, nor any DLT. Seven patients (58%) experienced grade I toxicities, four patients (33%) experienced grade II toxicities, and two patients (17%) experienced grade III toxicities. The most common toxicities were gastrointestinal, and the majority were grade I/II consisting of abdominal pain, nausea, vomiting, constipation, abdominal distention, and diarrhea. The most common toxicity overall was abdominal pain, which occurred in five patients (42%). Of the grade III AEs, one patient experienced abdominal pain and another experienced anemia (at least partially attributed to 5-FU bolus). There were no grade IV toxicities. A summary of all AEs is listed in Table Adverse events during the treatment period