Principal findings
In this study, the use of the discontinuation strategy arriba-PPI in general practice resulted in a greater reduction in PPI prescriptions than with usual care. Consultation with arriba-PPI led to discontinuation or reduction attempts in almost half the patients. More than a third of the patients who had decided to discontinue PPI are still taking no PPI at 6 months. Overall, DDD PPI prescription rates in all intervention patients were significantly decreased by 22% at 6 months and that level was maintained at 12 months.