Discussion
low baPWVIndicators of arterial stiffness
CVD, EVENTS, RECRUITMENT, ARTERIAL STIFFNESS
In this study, NMN supplementation was shown to be safe and beneficial for the activation of NAD metabolism in apparently healthy middle-aged individuals. We also found that 12-week supplementation with 250 mg NMN tended to reduce baPWV values. A previous meta-analysis of longitudinal cohort studies investigating baPWV showed that the risk of cardiovascular events associated with high baPWV is almost three times that associated with low baPWVIndicators of arterial stiffness, such as PWV, have been reported to correlate well with age, and the estimated age of blood vessels can be calculated from a subject’s baPWV valueAs observed in the subgroup analyses limited to participants with higher-than-mean CVD risk factors, NMN’s baPWV-reducing effect was more pronounced in participants with higher BMI and blood glucose levels. Interestingly, these subgroups had no change in BMI and blood glucose levels after the 12-week supplementation. However, NMN intervention significantly decreased diastolic blood pressure in participants with higher-than-mean blood glucose levels (Supplementary Table In recent years, it has been clarified that adipocytokines secreted by adipocytes are closely related to CVDsThis study’s results may have been influenced by several limitations: inappropriate recruitment of participants, the significant differences between both groups in baseline parameters other than those detailed in Table In conclusion, this study provides the first insight into the effects of long-term NMN supplementation on CVD risk factors, including baPWV value, suggesting that further clinical trials are beneficial to establishing NMN’s benefits for reducing arterial stiffness.