Discussion
acute disease, Disability, disability
ACUTE DISEASE, MALIGNANCIES, ACUTE DISEASES
The main result of this longitudinal study is that, irrespective of all measured potential confounders, disability (defined as a GIR score ≤ 3) in early COVID-19 was associated with 1-year mortality among geriatric patients.The association between mortality and disability during acute diseases has been extensively investigated, mainly in intensive care unit (ICU), and is well-recognized to complement the effect of age to predict mortality in older adults following an acute disease [Disability is defined as the loss of functional and cognitive capacities, ie the possibility and ability to perform daily activities in an appropriate way, and requiring assistance to carry out acts of daily living [We also found that the history of malignancies predicted greater 12-month mortality in older adults with COVID-19. This result is fully consistent with previous literature that retained this variable as on the main prognostic factor in COVID-19 patients, particularly during the first wave of the pandemic [Our study has some limitations. First, it was a single-centered study, and all patients were frail elderly patients hospitalized for COVID-19, who might be unrepresentative of the general population of older adults, therefore disability and mortality may be over-estimated. Second, the observational design was less robust than an interventional design and prevents any conclusion on causality. Third, during the first wave, PCR diagnosis was not always available and some diagnoses in our study were made using chest CT-scan [