RVI, IVC, ITH index, wGII Max, Loss9p21.3
tumours, tumour
REGRESSION, TUMOUR, TUMOURS
The AUROC performance in these targets is between 0.680 and 0.862, and the common theme is that all five targets are associated with the shape feature group for the whole ROI set (Table The features and LR coefficients of the best final models are detailed in Table Logistic regression coefficients, AUROC and The associations between shape features and ITH index, wGII Max and Loss9p21.3 are consistent with previous findings showing that these targets are associated with tumour growth modes, such as surface or volume growth [RVI and IVC invasion are processes that are sometimes detectable on CT scans by inspection of the relevant vascular structures, but these image regions are not included in the ROIs used here for radiomic analysis. However, an association between these targets and tumour volume is plausible since larger tumours are more likely to impinge on surrounding structures. Follow-up work in the full cohort of 320 patients is needed to determine if these associations are reproducible, and a case-by-case analysis is warranted to further elucidate this finding.