Ethics approval and consent to participate
The study was preregistered at the Chinese Clinical Trial Registry (Trial registration number: ChiCTR2000031659, Date of registration: 06/04/2020). All methods in this study were carried out in accordance with the Declaration of Helsinki and had been approved by the China Ethics Committee of Registering Clinical Trials approved this study (ChiECRCT20200077). Informed consent was obtained from all subjects involved in the study.