Statistical analysis
SECONDARY
All analyses for testing the efficacy with the primary and secondary measures were analyzed based on the intent-to-treat principle using a linear mixed model (LMM). For the primary outcome, the dependent variable was the GRID-HAMD score and the independent variables were assignment (i.e. UP-TAU Missing data were imputed with multiple imputations by chained equation using mice package (3.7.0) in R version 3.6.2 (van Buuren & Groothuis-Oudshoorn, 