Missing Scheduled Study Visits
UC
All patients completed baseline assessments before the lockdown. Among the patients who were assigned to the IS group (n = 65), five patients withdrew from study; one of them was unable to complete the baseline visit due to COVID-19. One patient stopped using the IS system at week 4 due to COVID-19 concern and was followed without the IS system. For the UC group, one withdrew due to COVID-19. After baseline visits, seven participants were lost to follow-up because of COVID-19; five in the IS group and two in the UC group. One participant in the IS group went out of the country after week 8 and was stuck abroad due to COVID-19 until week 24. Another stopped wearing the patch from week 8 to 12 due to concerns about the adhesive patch and COVID-19. Among all participants, only one in the IS group reported having COVID-19, resulting the inability to attend one study visit. We profiled the study visits of both study groups (IS: n = 54, UC: n = 58) before and after COVID-19 lockdown in Fig. 
Profile of missing study visits for (Each row represented one participant in the study arm. Blue squares represented the completed study visits and red squares the missed study visits. Purple square indicates lost to follow up. The vertical dashed line on the graph depicts the time of the COVID-19 lockdown