Patient population
upper urinary tract or urethra, clinical stage
DISEASE, APPENDIX
Eligible patients must have histologically confirmed UC of the bladder, upper urinary tract or urethra, clinical stage cT4NxM0 or cTxN1-N3 M0, and had at least stable disease after a minimum of 3 or a maximum of 4 cycles of platinum-based induction chemotherapy. A maximum of 50% divergent differentiation of histological subtypes is permitted. Clinical staging is based upon bimanual examination under anesthesia, computerized tomography (CT) with or without Positron Emission Tomography (PET) scan. Resection of the disease with curative intent should be possible and is assessed at a multidisciplinary board meeting. Patients must be fit and willing to undergo surgery. WHO performance status 0–2 and adequate bone marrow, renal and liver function are required. Further details on inclusion and exclusion criteria can be found in Appendix 1.