2.4. Outcomes
blood loss, hypovolemic shock
BLOOD LOSS, HYPOVOLEMIC SHOCK
Originally, the protocol for the study designated only the total blood loss as the primary outcome. However, after team discussions, it was deemed meaningful to explore potential differences between the two groups in terms of blood transfusion rate, decrease in Hb level, and calculated blood loss. Consequently, we decided to include blood transfusion rate, decrease in Hb level, calculated blood loss, and invisibly estimated total blood loss as primary outcomes in our study design. Allogeneic blood transfusion of red blood cells was triggered when the hemoglobin (Hb) level dropped below 8 g/dL, or when any signs of hypovolemic shock were observed. We calculated the patient’s blood volume (PBV) based on Nadler’s formula [To further assess the practical significance of the observed differences between the TXA group and the Tisseel@ + TXA group, we calculated Cohen’s d as a measure of effect size. This effect size will provide additional insights into the magnitude of the observed differences in blood loss between the two treatment groups.