Study outcomes
SECONDARY
The primary outcome was the analysis of serum GDF-15 expression changes between groups after 6 months following NSPT protocols. Furthermore, the impact of NSPT on GPx-1, hs-CRP, and SP-D concentration changes was analysed after 6 months of treatment. The secondary objective was to examine the influence and interaction between NSPT protocol (Q-SRP used as a reference) and the duration of NSPT (6 months) on GDF-15, GPx-1, hs-CRP, and SP-D changes, as well as whether high baseline levels of GDF-15, GPx-1, hs-CRP, and SP-D influenced the efficacy of periodontal treatment after 6 months of follow-up.