Statistical methods
REGRESSION, EVENT
Analyses were based on a pre-specified statistical analysis plan and performed on an intention-to-treat basis. Continuous outcomes were compared using linear regression, time to event outcomes using Cox regression, categorical/ordinal outcomes using logistic regression and continuous longitudinal outcomes using linear mixed-effects regression. All analyses used ICBC as the reference group and were adjusted for surgical complexity (RACHS <3 vs ≥3) and baseline measures where collected. Outcomes are reported as effect sizes with 95% confidence intervals (CIs) and likelihood ratio tests were used to determine statistical significance. Further details, including pre-planned sensitivity analyses, are in the 