2.2.4. Clinical Outcomes (Secondary)
ADRD
Cognition. Cognitive outcomes were evaluated in-person at baseline, 6-weeks, and 3-months using the updated Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) forms A, B, and C at each time point, respectively. Given the focus on evaluating cognitive domains associated with ADRD risk, the RBANS Total Score and Delayed Memory Index were examined for change across time and group differences. These standardized scores are normed based on participant age, with a score of 100 indicating average performance compared to peers. Of note, due to an administration error, one participant was missing baseline RBANS A data for the total score and Delayed Memory Index.Cardiometabolic. Participants were instructed to fast overnight (8–10 h) prior to reporting to the laboratory in the morning for study visits. Fasted blood samples were collected at baseline and 6-weeks, while height, weight, and blood pressure were assessed at all three study visits. All venous blood samples were obtained in vacutainers with the appropriate anticoagulants. Serum and plasma were separated by centrifugation at 3500× 