Serum anti-SARS-CoV-2 specific antibody titers after full vaccination
RBD
REGRESSION
In the fully vaccinated, the median serum anti-S IgG titer was 1,680 (756–14,000) BAU/ml in the active treatment arm (Serum anti-SARS-CoV-2 specific antibody (a-d) and virus-neutralizing antibody levels (e) in study participants who received two vaccine doses during the study period (intention-to-treat population). S = spike, RBD = receptor-binding domain, nAB = neutralizing antibody. Statistical comparisons between the groups were performed with independent t-test using log-transformed values except nAB titers which were compared with non-parametric Mann-Whitney test. The bar plots show median, and the dots represent individual values within the group.Based on the assumption that age, BMI, time from vaccination to sampling, and time between the two vaccine doses can influence the measured antibody titers, we performed a multivariate linear regression analysis to study the associations between these variables. This analysis revealed that only time from vaccination had a statistically significant effect on all measured virus-specific antibody class levels except nABs. Thus, we decided to split the data according to the time elapsed since vaccination. First, we investigated individuals in the fully vaccinated subgroup who had received their second vaccine dose more than 14 days before blood sampling which is generally considered as the time regarded for full vaccination effect. This analysis showed that the active treatment arm (Serum anti-SARS-CoV-2 specific antibody (a-d) and virus-neutralizing antibody (e) levels in study participants who received two vaccine doses during the study period and were sampled more than 14 days after the second dose (intention-to-treat population). The red dots represent individuals who were either partly or fully vaccinated with the Astra-Zeneca’s AZD1222 vaccine. S = spike, RBD = receptor-binding domain, nAB = neutralizing antibody. Statistical comparisons between the groups were performed with independent t-test using log-transformed values except nAB titers which were compared with non-parametric Mann-Whitney test. Black p-values refer to the whole population and red p-values to the population who received only Pfizer-BioNTech’s BNT162b2 vaccine or Moderna’s mRNA-1273 vaccine. The bar plots show median, and the dots represent individual values within the group.Serum anti-SARS-CoV-2 specific (a-d) and virus-neutralizing (e) antibody levels in study participants who received two vaccine doses during the study period and were sampled more than 28 days after the second dose (intention-to-treat population). The red dots represent individuals who were either partly or fully vaccinated with the Astra-Zeneca’s AZD1222 vaccine. S = spike, RBD = receptor-binding domain, nAB = neutralizing antibody. Statistical comparisons between the groups were performed with independent t-test using log-transformed values except nAB titers which were compared with non-parametric Mann-Whitney test. Black p-values refer to the whole population and red p-values to the population who received only Pfizer-BioNTech’s BNT162b2 vaccine or Moderna’s mRNA-1273 vaccine. The bar plots show median, and the dots represent individual values within the group.