Background and rationale {6a}
myocardial damage, ST-segment elevation myocardial infarction, ischemia, inflammation, reperfusion injury, acute myocardial ischemia, infarct
SYSTEMIC INFLAMMATORY RESPONSE, ISCHEMIA, INFLAMMATION, ACUTE MYOCARDIAL ISCHEMIA, INFLAMMATION, INFARCT
In patients with ST-segment elevation myocardial infarction (STEMI), early reperfusion is pivotal to shorten time of ischemia and thereby reduce myocardial damage (infarct size) [Inflammation has been suggested as an important mediator for ischemia–reperfusion injury, and inflammation is induced immediately after the onset of acute myocardial ischemia and is exacerbated following reperfusion [Glucocorticoid, either endogenous or via administration, is a main driver in the regulation of the systemic inflammatory response [