Author contributions
Q.Z., J. Yin and J. Yuan contributed equally to this work. Q.Z., J. Yin, L.T. and K.W. conceived and designed the study. J. Yin provided study material or treated patients. R.W. performed DNA and RNA extraction of biological samples and prepared libraries for sequencing. All authors collected and assembled the data. Q.Z., J. Yuan and Y.L. performed all the bioinformatic analysis of multiomics sequencing data and developed the tables and figures. Q.Z. conducted the literature search and wrote the manuscript. All authors were involved in critical review of the manuscript and approved the final version.