Ethics approval and consent to participate
Ethics committee approval was obtained from the Ethics Committee of the Hebei Provincial People’s Hospital(2021 Scientific Research Ethics Review [301]). This study was registered in the Chinese Clinical Trial Registry with Portal Number ChiCTR2100050430(27/08/2021). This study respects the life, health, dignity, self-determination, privacy and confidentiality of the subjects’ personal information of all participants. All methods were carried out in accordance with the guidelines and provisions of the Declaration of Helsinki. The purpose and requirements of the study were explained to all patients, and all patients signed written informed consent before the start of the trial.