Stability of connectivity and target location before vs. after RSNM targeted rTMS treatment in TBI-D patients
TBI depression
13 TBI depression patients were scanned again after a full course of active rTMS (n = 9) or sham (n = 4), which was applied to the RSNM target derived from the pre-TMS scan. Connectivity with the normative sgACC seed map remained relatively stable for the RSNM target and the structural target (Fig. (Between the two scan sessions (pre- and post-treatment), the mean absolute Euclidean distance change in target coordinates was 6.6 mm for RSNM targets and 17.7 mm for sgACC-derived targets (Wilcoxon matched-pairs signed rank test p < 10Thus, after active or sham rTMS at the RSNM target, the location of the RSNM targets remained more stable than the sgACC-derived targets. Consistency of connectivity was similar between RSNM targets and structural targets. Of note, we did not directly assess stability of the location of the sgACC-derived targets before and after stimulation at these targets because no stimulation was performed at sgACC-derived targets.