Study interventions and outcomes
kidney stone disease, kidney stone
KIDNEY STONE, BLIND
Study participants received either a daily dose of 2000 IU oral cholecalciferol for 12 weeks (maintenance dose) or a weekly dose of 50,000 IU oral cholecalciferol for eight weeks (loading dose). The final assessment was performed 12 weeks after the beginning of the study. These doses were selected according to loading treatment and maintenance therapy recommendations for VDD management, published by the endocrine society clinical practice guidelines [Because of the differences in the study protocol, participants and researchers were not blind to the study protocol, and only the statistician was blinded for the statistical analyses.Study variables included demographic, anthropometric, the duration and episodes of kidney stone disease, serum 25(OH)D, parathyroid hormone (PTH), calcium, and phosphate concentrations, 24-h urine analysis for volume and concentration of urea, creatinine, calcium, sodium, potassium, phosphate, magnesium, citrate, oxalate and uric acid, and also participant`s dietary intake data. Demographic, anthropometric, and kidney stone history data were collected at the beginning of the study. Serum and 24-h urine samples were taken at the beginning and the end of study. All the laboratory measurements were performed as we reported in our previous study [