Progression-Free Interval
urothelial tumors, urothelial tumor
RECURRENCE, DISEASE, PROGRESSION, CARCINOMA IN SITU, METASTASES
Kaplan-Meier 5-year analyses of progression-free intervals as time from date of study entry to date of progression, for selenium and vitamin E. Progression was defined as recurrence with an increase in grade from grade 1 or grade 2 to grade 3 or an increase in T stage (determined by histopathologic analysis) or the new occurrence of carcinoma in situ (CIS) in a bladder previously free from CIS or the new occurrence of multiple urothelial tumors following the initial diagnosis of a solitary urothelial tumor. Progression was also reported if there was the need for a cystectomy because of refractory disease or the new development of nodal and/or distant metastases (determined by imaging). For those patients not observed to have experienced progression by the time of analysis, the interval was censored at the date last known to be progression free. HR indicates hazard ratio.