Aims
HCM, LVH, fibrosis, diabetes
MYOCARDIAL FIBROSIS, FIBROSIS, DIABETES, OXIDATIVE STRESS, LVH, HYPERTROPHIC CARDIOMYOPATHY (HCM), LEFT VENTRICULAR HYPERTROPHY
Hypertrophic cardiomyopathy (HCM) is characterised by left ventricular hypertrophy (LVH), myocardial fibrosis, enhanced oxidative stress and energy depletion. Unbound/loosely bound tissue copper II ions are powerful catalysts of oxidative stress and inhibitors of antioxidants. Trientine is a highly selective copper II chelator. In preclinical and clinical studies in diabetes, trientine is associated with reduced LVH and fibrosis, and improved mitochondrial function and energy metabolism. Trientine was associated with improvements in cardiac structure and function in an open-label study in patients with HCM.