Relationship of lipid mediators with protein mediators among PWH
inflammation, PWH
INFLAMMATION
As PWH with higher levels of the monocyte activation marker soluble CD14 (sCD14) have an increased risk of morbidity and mortality, another objective of this study was to determine the relationship of lipid mediators and sCD14 among PWH.At the family level, no statistically significant associations with ‘high sCD14’ (defined as those in the highest quartile) were observed after FDR adjustment (While our primary focus was on sCD14, we also explored the relationship of the lipid mediators of inflammation with additional markers including sCD163, IL-6 and CD4 T-cell activation (CD38+HLA-DR+). At the metabolome level, only PG had a strong inverse association with CD4 activation (OR: 0.29 (0.12, 0.71)). We did not observe statistically significant associations of other metabolomes or mediators, and their PCs with these markers (