PCOS phenotypes
PCOS, normo-androgenic, HA+PCO, hyperandrogenism, hyperandrogenic
POLYCYSTIC OVARIES, HYPERANDROGENISM
Differences in s-PROK1 were also analysed in subgroups stratified according to PCOS phenotypes. Patients from the pilot study (n=37) were not included in this analysis, as they were diagnosed according to the NIH criteria, and due to the lack of data in the presence or absence of polycystic ovaries, those fulfilling all three criteria and hyperandrogenism-oligo-amenorrhea groups could not been distinguished. In PregMet1 samples, s-PROK1 was not significantly different between PCOS phenotypes A (HA+PCO+ OA), B (HA+PCO), C (HA+OA) and D (PCO+OA) (p=0.177) (data not shown). s-PROK1 was lower in hyperandrogenic (median=6.86, 95% CI 6.86 to 9.69) compared with normo-androgenic women (median=6.86, 95% CI 7.00 to 88.69) (p=0.040) (Serum levels of PROK1 at pregnancy week 19 in women with PCOS and hyperandrogenism (n=164) compared with those without hyperandrogenism (n=64). Values are presented as median, interquartile ranges (P25–P75) and non-outlier ranges (min-max). Open circles represent outliers (1.5*the box-height from the box).