Background
glioblastoma, cancer, aggressive brain cancer, Glioblastoma
RECURRENCE, CANCER, GLIOBLASTOMA, GLIOBLASTOMAS, GLIOBLASTOMA
Glioblastoma is the most aggressive brain cancer. Over four decades, progress toward more effective therapies in this field has been limited. This situation, along with the idiosyncratic biology of glioblastoma, imposes a radical change in therapeutic development for this cancer [The findings above provide the rationale for a BMP4-driven, pro-differentiation clinical strategy for glioblastomas, tackling those key neurogenic mechanisms of malignant GSCs that are fundamental for their onset, maintenance, recurrence, and incurability. This innovative strategy, aimed at shrinking the stem cell pool that sustains glioblastoma’s growth, simultaneously increasing the efficacy of adjuvant therapies [