Echocardiographic outcomes
end-systolic stressDiastolic dysfunction
A detailed description of the echocardiographic analysis principles can be found in supplemental file The following outcomes will be assessed in a core-echo lab:Left atrial size (left atrial volume index)Left ventricular sizeCardiac index (cardiac output/body surface area)Left ventricular ejection fractionTricuspid annular plane systolic excursion (TAPSE)Midwall fractional shorteningGlobal longitudinal strainCircumferential end-systolic stressDiastolic dysfunction estimated by the relationship between left ventricular filling and the interval between two successive R waves on ECG (R-R interval) for the individual patientPulmonary pressure