Introduction
fever illness
RESPIRATORY DISEASE, VIRUS, INFLUENZA, INFLUENZA
Influenza, a contagious respiratory disease, which induced by the influenza virus that resulting in high morbidity and mortality worldwide. Outbreaks of influenza are usually earliest detected in children with fever illness [Currently, four classes of antiviral drugs are approved for influenza treatment in several countries, mainly including adamantane, neuraminidase inhibitors, membrane fusion inhibitors, and RNA-dependent RNA polymerase inhibitors [Oseltamivir carboxylate, which is a neuraminidase inhibitor (NAI), is produced by hydrolysis of oseltamivir through the ester bond and inhibits the isolation of mature influenza virus from host cells by inhibiting neuraminidase, thereby inhibiting virus transmission in humans [TAMIFLU® was jointly developed by Roche Registration Ltd and Gilead Sciences, Inc. The capsule was first approved for marketing by the FDA in October 1999, and the oral suspension was approved for marketing by the US FDA in December 2000. It has been marketed in many countries and regions around the world, and is recognized as one of the most effective drugs against influenza in the world. The purpose of this study was to assess the bioequivalence of oseltamivir phosphate for suspension (Hetero Labs Limited, 6 mg/ml after reconstitution, dose: 75 mg/12.5 mL) and TAMIFLU® (F. Hoffmann-La Roche AG, strength 6 mg/mL, dose: 75 mg/12.5 mL) in Healthy Chinese volunteers.