Results
INTRAOCULAR PRESSURE
One-hundred-fifty-five patients were included in the study. Four patients were excluded because not properly randomised. Four patients from the citicoline oral solution-placebo arm and one from the placebo-citicoline oral solution arm were excluded because they did not complete any visit beyond the baseline, as reported in the CONSORT flow diagram (Supplementary Fig. Descriptive statistics at baseline, reported as median [interquartile range] for continuous values. BCVA = best corrected visual acuity; MD = mean deviation; RNFL = retinal nerve fiber layer; VFQ = Visual Function Questionnaire; SF = Short Form health survey. RNFL thickness and intraocular pressure are for the better eye. *One female subject missingGraphical representation of the results in Table Results of the sequence analysis at different time points. The table reports the estimate [95% confidence intervals] of the composite score from the model. The Bold: Graphical representation of the results in Table The results of subscale score analysis are reported in Fig. Sequence analysis for each subscale in the VFQ-25 questionnaire. The dots represent the estimates from the model; the error bars represent the 95% confidence intervalsOverall, both placebo and citicoline oral solution had a significant effect compared to no treatment (i.e., to baseline, see Fig. Results of the treatment analysis. The table reports the estimate [95% confidence intervals] of the composite score from the model. The Bold: A mixed effect model was used to explore the effect of the baseline composite score on the change obtained with the placebo and citicoline oral solution respectively. The differential effect of the treatment was modelled through an interaction term between the treatment and the baseline composite score. If significant, this indicates a significant difference in the effect of citicoline oral solution compared to placebo at the same baseline score. The Change from baseline obtained with citicoline oral solution and placebo stratified by baseline composite scoreA model similar to the one for the baseline score was used to study the correlation between the mean deviation (MD) of the better eye and the composite score. MD had a significant effect on the composite score (The analysis of SF-36 questionnaire was conducted using the same approach as the VFQ-25. The only difference was that the two main summary scales, the mental component, and physical component summary, needed to be kept as separate scores. The estimates of the model for the main outcome are reported in Table Results of the sequence analysis at different time points. The table reports the estimate [95% confidence intervals] of the composite score from the model. The Results of the treatment analysis. The table reports the estimate [95% confidence intervals] of the composite score from the model. The Bold: 