Background
SE, Status epilepticus, convulsive SE, cerebral damage
STATUS EPILEPTICUS
Status epilepticus (SE) is an emergency condition that is life-threatening with respiratory and circulatory system failure and may cause irreversible cerebral damage.Phenytoin is recommended as an effective second-line therapy for SE.Levetiracetam (LEV), which primarily binds to synaptic vesicle protein 2A and regulates the release of neurotransmitters,To establish intravenous LEV for the treatment of SE, we herein conducted a multicentre non-inferiority RCT, in which adult patients with convulsive SE transported to an emergency room were randomised into LEV and FPHT groups as a second-line treatment after the administration of diazepam, a typical benzodiazepine and their efficacies were compared. Since the participating facilities were recruited around Ibaraki in Japan, this study was entitled the 