Study design
This open labelled randomized control trial study was conducted during the period from March 21, 2021, to September 30, 2021, recruiting patients from the outpatient clinics of Alexandria University hospitals, the largest hospital in Alexandria governorate that services also residents of the other 2 neighbouring Egyptian governorates, as well as those referred by clinicians working in inpatient and outpatient facilities. The report of this trial follows the recommendations of the Consort Statement for the quality of reports of parallel group, randomized trial.