3.4. Predicted Chemical and Biological Drug Targets in COPD-Predominant Monocyte and Alveolar Macrophage Clusters
COPD
COPD
We predicted the drug targets on the basis of the DEGs in the COPD-related clusters. To do this, we included an analysis of the differentially expressed genes from COPD-predominant vs. control-predominant clusters (e.g., alveolar macrophages (Cluster 0 vs. Cluster 12) and classical monocytes (Cluster 15 vs. Cluster 11), as well as mixed clusters (COPD vs. control cells within the same non-alveolar macrophage Cluster 6, classical monocyte Cluster 2, and non-classical monocyte Cluster 10). Interestingly, fluticasone propionate, a drug commonly used in COPD, was significantly enriched in all cluster comparisons, and was within the top five predicted drug targets across three of the five comparisons (