Methylphenidate normalizes state-specific hyper-connectivity of the DMN in children with ADHD
ADHD-related dysfunction, ADHD
CORTEX
Our next goal was to uncover latent space features that define the abnormal state S2 in children with ADHD and determine whether methylphenidate can normalize these features. Each latent brain state is characterized by distinct patterns of functional connectivity between the key nodes of the SN, FPN and DMN. These networks play an essential role in a wide range of attention and cognitive control tasks, with a high degree of reproducibility [Our findings provide novel evidence on aberrant functional connectivity of cognitive control systems in children with ADHD and the impact of methylphenidate on these systems. We found that, compared to controls, children with ADHD exhibited higher functional connectivity between the two key nodes of the DMN, the posterior cingulate cortex (PCC) and the ventromedial prefrontal cortex (vmPFC). This is in line with previous findings that show ADHD-related dysfunction in the DMN [