Hematology
The hematological examination was performed prior to infusion, on Days 2 and 10 PoI, and on terminal specimens. Mean levels of red blood cells (RBCs), hemoglobin (HGB) and hematocrit (HCT) dropped below normal ranges (~40% reduction over the baseline value) after infusion of ANTHRASIL or IGIV, suggesting the animals were becoming anemic; however, this never became severe enough to warrant euthanasia or other intervention.While all terminal specimens were below normal ranges, it was not determined if the levels in surviving animals returned to normal as no specimens were collected after Day 10 PoI. The mean levels of RBCs, HGB, and HCT were slightly below normal ranges in ANTHRASIL-treated animals in non-terminal specimens. Post-challenge, white blood cell counts were decreased prior to treatment, while neutrophil counts increased as the study progressed. Lymphocyte counts decreased from baseline prior to treatment but seemed to rebound by 48 h post-infusion. Hematology data from the rabbit study are presented in 