Introduction
Human milk substitutes
Human milk substitutes (herein referred to as The non-essential, amino acid glutamic acid is found in the diet in free (non-protein bound) and bound form, and one of its salts (monosodium glutamate, MSG) is a well-known flavor enhancer additive. Although considered a Generally Recognized as Safe (GRAS) substance by the US Food and Drug Administration and considered safe by other health organizations, including the Joint FAO/WHO Expert Committee on Food Additives and the European Food Safety Authority (EFSA), the safety of glutamic acid–glutamates as food additives was re-evaluated by the EFSA Panel on Food Additives and Nutrient Sources [In the years following this EFSA report, many questioned the strength of the evidence and the appropriateness of using a risk assessment paradigm for a macronutrient [To further extend the analyses put forth by Koletzo [