Author contributions
M.J.B., M.G. and W.M.D. conceived of and designed the study. X.W., E.G., R.S., W.B., G.A., S.M.O., K.L., E.A. and J.S. ran the study and collected the data under the supervision of M.J.B., M.G., J.K.C and W.M.D. J.S. was trial coordinator. AVS was performed by M.M., B.K. and N.H. N.B., I.B., S.H., V.W., D.G. and F.A. supervised and coordinated the [