2. Methods
This study (ISRCTN: 76597892) received ethical and regulatory approval and is described in detail herein, including the published primary outcome [The original study intervention compared the standardised Concentrated Additional Macronutrients Parenteral nutrition regimen with the contemporary standardised, concentrated neonatal PN (control) regimen [All infants received clinical care in accordance with LWH NPN protocols, including fluid management; introducing, increasing, and stopping enteral feeds; and biochemical monitoring. The study intervention continued until 28 completed days of life. PN was discontinued once enteral feeds exceeded 75% total. The transition from PN to enteral feeds has been described previously [Parents were contacted after their children had reached 2 years of corrected gestational age to make arrangements for a Bayley III neurodevelopmental assessment to be performed in their own homes whenever possible. The aim was to perform assessments at 30 months CGA using one of two assessors (MT or SP). When home assessment was not possible, the assessors used local outpatient clinics. The raw scores of each subtest were converted to scaled and composite scores. A composite score of 100 is equivalent to normative mean. The combined score is a cognitive/language average validated to offer comparison with the Mental Developmental Index. Bayley III cognitive, language, and motor composite scores were calculated along with the combined composite score as described by Johnson et al. [