Immune cell subsets by pCR status.
tumour
CYTOTOXICITY, TUMOUR
Proportion of CD45+ cells which stained positive for The proportion of CD3+ T cells significantly increased following neo-adjuvant treatment (Fig. Diametric changes were observed in other circulating immune cell populations. There was a significant decrease in the proportion of CD56+ NK cells (Fig. Peripheral T cells are not expected to elicit cytotoxic effects in the assays used in this study as they have not been antigen-primed or otherwise activated. However, NK cells and monocytes are mediators of direct cytotoxicity against tumour cells and ADCC [Expression of the immune checkpoint PD-1 was investigated in CD45+ PBMCs to assess potential immunosuppressive phenotypes. CD45+PD-1+ immune cell levels were unchanged between pre- and post-treatment samples (Fig. 