Ethical approval and consent to participate
All procedures performed in studies involving human patients were in accordance with the ethical standards of the Ethical and Scientific Committee of Six hospitals with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Specifically, the IRBs that approved the study were the IRB of Shuguang Hospital affiliated with Shanghai University of Traditional Chinese Medicine (reference: 2014-341-37-01), the IRB of Shanghai East Hospital affiliated with Tongji University (reference: 2013-24), the IRB of Renji Hospital affiliated with Shanghai Jiaotong University (reference: 2015-001), the IRB of Shanghai Changning Tianshan Traditional Chinese Medicine Hospital (2017TSKY04), and the IRB of Shanghai Tongren Hospital affiliated with Shanghai Jiaotong University (reference: 2017-32). Shanghai Hudong Hospital accepted the ethics approval granted by Shuguang Hospital. Informed consent was obtained from all patients included in the study. Details that might disclose the identity of the patients under study were omitted.