DISCUSSION
migraine, stress insults, pain
MIGRAINE
The present trial assessed the effectiveness of eye movement exercise and diaphragmatic breathing with jogging in individuals with migraine. The first interventional group received eye movement exercise plus jogging, the second interventional group received diaphragmatic breathing plus jogging, and the control group only received TAU. The results showed significant effects of the interventions on migraine symptoms in the interventional groups (Figure Although the results of a meta‐analysis (Naugle et al., As a diagnostic criterion, individuals with migraine have a fear of movement or kinesiophobia (Benatto et al., In the present trial, another essential guided behavior was diaphragmatic breathing. To be precise, jogging itself may increase exercise‐induced stress insults in a brain with migraine; however, diaphragmatic breathing helps promote stress‐response control indices and potentiate cortical readiness before jogging (Martarelli et al., All participants in the present trial were female individuals with migraine. Because of the lack of generalizability of our findings to male individuals, a similar trial with the same approach and method should be performed with male individuals with migraine. Moreover, heterogeneity in the rate of prescribed medication and OTC drugs use in the control group was another limitation of the present trial. In the control group, we did not ask individuals to keep a journal of the medication that they were taking for their pain. However, no single or specific prescription has consistent or long‐term efficacy for migraine. Even recording the rate of medication use over two years by the control group individuals was considered an unviable goal and could not help interpreting the trial outcomes.Furthermore, given the Middle Eastern context of the present trial, future studies can replicate the trial with individuals from different cultural, racial, and ethnic backgrounds. Since the acceptability and feasibility of eye movement exercise plus jogging or diaphragmatic breathing plus jogging intervention were not considered in the present preliminary trial, future studies are recommended to consider these criteria in their designs. Although the current comparative effectiveness trial was non‐inferiority (