1. Introduction
postoperative pain, inflammation, pain, knee arthroplasty, TKA, trauma
ADVERSE EFFECTS, INFLAMMATION, KNEE OSTEOARTHRITIS
Total knee arthroplasty (TKA), a surgical method for the treatment of terminal stage knee osteoarthritis, can effectively relieve pain and restore knee function. However, patients experience moderate to severe pain after TKA. Acute pain after TKA can have a negative effect on enhanced recovery after surgery among patients [The mechanism of postoperative pain is complicated. In the past, it was believed that postoperative pain after TKA was mainly nociceptive pain caused by surgical trauma and tissue inflammation [The use of oral analgesics in advance is a convenient and effective method for preemptive analgesia after TKA. Celecoxib or other cyclooxygenase-2 (COX-2) inhibitors selectively inhibit the activity of COX-2, reduce prostaglandin production and inflammatory reactions, and achieve effective control of pain and anti-peripheral pain sensitization effects. In particular, it has a positive effect on reducing nociceptive pain mediated by inflammatory mechanisms after TKA [The purpose of our study was to evaluate the effectiveness of pregabalin combined with celecoxib as TKA preemptive analgesia by compared the pain score, cumulative dosage of opioids, high-sensitivity C-reactive protein (hs-CRP) level, and adverse effects after TKA. We hypothesised that the effectiveness of pregabalin combined with celecoxib as TKA preemptive analgesia would lead to satisfactory clinical outcomes.