2.9. Bioinformatic Processing and Statistics
REGRESSION, PLAQUE
Clinical data, plaque score, and BOP % were processed between groups using multiple linear regression (ANCOVA). Changes in plaque and BOP % within groups were compared with analysis of variance (ANOVA) using Tukey correction and visualized in a spaghetti plot. Calculations and visualizations were made in R (version 4.2.3) using R studio (IDE version 2023.04.1 + 446). The supragingival microbiota was as previously [Data on cytokines and proteases were log-transformed and compared within groups using repeated-measures one-way ANOVA with Tukey correction, while differences between groups were compared using ANCOVA with baseline measurements as covariates using R (version 4.2.2) and R studio (IDE version 2023.06.2 Build 561). A 