Objectives {7}
nonunion, fractures, fracture-related infection, fracture-related
The primary objective of this study is to determine the efficacy of intraoperative, locally administered gentamicin versus placebo in the management of open tibial shaft fractures as measured by the prevention of fracture-related infection (FRI). Secondary objectives include assessing the efficacy of local gentamicin versus placebo on the occurrence of nonunion and unplanned fracture-related reoperations.