Ethics approval and consent to participate
All clinical trials have been approved by The First Affiliated Hospital of Hunan Normal University (Hunan Provincial People’s Hospital, 2023 No. 180), and all methods were carried out in accordance with relevant guidelines and regulations. Informed consent has been obtained from all subjects and/or their legal guardian(s). All animal experiments were carried out in accordance with relevant guidelines and regulations, and reported in accordance with ARRIVE guidelines. All experimental protocols were approved by ethics committee/IRB of the First Affiliated Hospital of Hunan Normal University (Hunan Provincial People’s Hospital, 2021 No. 43).