The effectiveness of the 
REMISSION
There are few studies on ICd in NDMM, and no studies have compared ICd with Id, especially in the elderly and frail patients with NDMM. Our results indicated an overall ORR of 75.0%, indicating that oral ICd and Id could provide good tolerance and therapeutic effects in the elderly and frail patients with NDMM. In particular, comparisons between Id and ICd were conducted. The ORR of ICd and Id regimens was 78.9% and 70.6%, respectively, and the power value of the ORR between the two groups is was 0.875. Although the number of patients included is currently small, the power is >0.8. After four cycles, the rate of ≥PR in the ICd and Id groups was 76.5% and 57.1%, respectively, whereas the corresponding ≥VGPR rates were 47.4% and 23.5%, respectively. The ICd regimen seemed to result in faster remission and higher ORR than the Id regimen, and additional cycles could improve the depth of response (Figures The ICd regimen exhibited promising efficacy in NDMM.