Materials and methods
schizophrenia
DYSFUNCTION, PATHOPHYSIOLOGY
We collected resting state-fMRI, genetic and clinical data from 146 in- and out-patients suffering from schizophrenia. To link the obtained resting state-fMRI connectivity findings of the genetic variant to the pathophysiology of schizophrenia, resting state fMRI data from 142 healthy control subjects were compared with the whole sample of patients suffering from schizophrenia. The healthy control subjects participated in different study arms of the same research network (APIC), but no genetic information was available. For the comparison of genetic and pharmacological brain signatures of NMDAR dysfunction, we also analyzed a pharmaco-fMRI dataset comprising resting state—fMRI data from 28 healthy male subjects who participated in a single-blind, placebo-controlled study with a three-way cross-over design applying ketamine, midazolam and placebo [