Trial design
PENFUP study was a multicenter, randomized (allocation by opaque sealed envelope), double-masked, parallel-group 1:1, controlled trial (ClinicalTrials.gov ID: NCT02565745), to evaluate the efficacy of hydrocolloid dressings and cost-effectiveness compared with the control group (conventional care using petrolatum-VaselineParticipants were allocated to the intervention group or to the conventional care prior to signing the informed consent form between January 1, 2015, and December 12, 2017, at two Third-level hospitals in Colombia at two Third-level hospitals in Colombia.