INTRODUCTION
rash, pain, Herpes zoster, HZ, PHN
POSTHERPETIC NEURALGIA, PHN, VIRUS INFECTION, DISEASE, HERPES ZOSTER, NEUROINFLAMMATORY RESPONSE, PATHOGENESIS, COMPLICATIONS
Herpes zoster (HZ) is a comment disease with distinctive clinical conditions, it is caused after varicella‐zoster virus infection. According to epidemiological investigation, one in four people might suffer from HZ during their lifetime, and for individuals aged over 50, the incidence for HZ increased to almost 50% (David, Postherpetic neuralgia (PHN) is one of the most common complications of HZ, PHN is defined as pain that persists for 3 months or more after the resolution of the initial rash. The risk of PHN is reported between 5% and 30% after the break out of HZ. Advanced age is one of the risk factors for developing PHN, as about 12.5% of HZ patients over 50 years old can develop PHN, and the increase in risk varies from 1.22 to 3.11 for every 10 years of age (Hadley et al., Numerous researchers have investigated the potential mechanism for the residual pain of PHN. Theories including peripheral sensitization, central sensitization and peripheral neuroinflammatory responses have been identified, yet the pathogenesis of PHN remains unclear (Hoon, One approach to prevent PHN could be autologous fat grafting, a widely used technique in cosmetic surgery and has proven to be a safe procedure in the past 30 years (Bucky & Percec, 