SARS-CoV-2 T-cell responses
SARS-COV-2 INFECTION
Both protein and mRNA vaccines enhanced CD4Activated T cell responses towards ancestral and beta RBD-derived peptides. Proportion of CD134Cytokine profiles from CD4 and CD8 T cells stimulated with ancestral and beta RBD-derived peptides were also assessed using intracellular cytokine staining. These data revealed a baseline displayed a mix of Th1 (IFN-γ, TNF) and Th2 cytokines (IL-5 and IL-13), presumably established by prior vaccination and/or prior SARS-CoV-2 infection. There was no consistent change in cytokine profiles in the day 29 samples for either the protein or mRNA vaccines (