Participants and methods
This randomized controlled clinical trial was carried out from November 2020 to July 2021 upon approval from the Institutional Review Board of Shanghai Children’s Medical Center on 17/06/2020 (SCMCIRB-Y2020095), and was registered at the Chinese Trial Registry (ChiCTR2000039622) on 03/11/2020. Informed consent was obtained from the parents or legal guardians ofall participants. The trial was carried out following the Declaration of Helsinki, and the authors guaranteed the accuracy and completeness of the data and analysis of this paper.