Conclusions
CRC, cancer, GI cancer, overweight, noncolorectal GI cancers
CANCER, OBESE, GI CANCER, CARCINOGENESIS
This cohort study found increased GI cancer risk among individuals with overweight and obese BMI reported at early, middle, and later adulthood. We also found that increasing BMI over time was associated with increased risk of CRC and noncolorectal GI cancers. This association was not modified by aspirin use 3 or more times per week. The results of the current study prompt further exploration into the mechanistic role of obese BMI in carcinogenesis. Finally, future research must focus on identifying cancer prevention mechanisms for this high-risk group.