Outcomes
tuberculosis
SECONDARY, TUBERCULOSIS
We had two coprimary outcomes focused on diagnostic accuracy and clinical effect. The diagnostic effect primary outcome was defined as the proportion of participants without tuberculosis (negative reference standard) correctly identified by the index test at day 8 (Pre-specified secondary outcomes were diagnostic accuracy in participants who could not produce sputum at day 1 and day 8, and antimicrobial resistance. We included the secondary diagnostic accuracy outcome because, in the study setting, as many as 13% of symptomatic adults do not produce sputum.