Strengths and limitations
death, COPD
COPD
This study is the first large randomized controlled trial assessing the effectiveness of palliative care integrated into regular COPD care. As part of a hybrid type 2 effectiveness-implementation study,However, our study also has limitations. Next to insufficient study power, we had a high rate of missing data due to the death of participants and high non-response to follow-up questionnaires. Missing data are expected in palliative care studies and increase with more items, quality of life questionnaires and longer follow-up time.