Monocytes
We then investigated trend in monocytes, specifically by distinguishing between classical and non-classical subsets (note that non-classical monocytes also included a small proportion of intermediate monocytes). Although no statistical significance was detected for the classical monocyte subsets (interaction p-value=0.50), for the non-classical monocytes we detected a strong association by arm and time (interaction p-value=0.03 in the adjusted model). Also in this analysis, the significance was likely driven by the difference at T6 when non-classical monocytes were significantly lower in B/F/TAF vs the DTG/3TC arm (diff =-6.7 cells/mm3, 95% CI; -16;+2.6). The difference was again attenuated at T12 (Monocytes by study arm—adjusted analysis.RCT, randomized clinical trial.