The alteration of the DLPFC after metformin treatment and its relationship with cognition improvements
MCC, CORTEX
After 12 weeks of treatment, we found significant time × group interaction effects on voxel-wise FC with the DLPFC subregions as seeds between the metformin group and the control group. These FC include as follows: left A9/46d to right anterior cingulate cortex/middle cingulate cortex (ACC/MCC); left A46 to right ACC; right A46 to right superior frontal gyrus/middle frontal gyrus (SFG/MFG), and to MCC (Fig. 