Introduction
tumor, node-negative breast cancer, Breast Cancer, TAXIS
TUMOR, NODE-NEGATIVE BREAST CANCER, BREAST CANCER, DISSECTION, SENTINEL LYMPH NODE, BREAST
Standard axillary lymph node dissection (ALND) was replaced by the sentinel lymph node (SLN) procedure in most patients with node-negative breast cancer (BC).However, in patients with hormone receptor (HR)–positive To our knowledge, the role of ALND to determine the nodal tumor burden to inform systemic therapy decisions in patients with clinically node (cN)–positive BC is not known. Oncoplastic Breast Consortium 03 (OPBC-03)/Tailored Axillary Surgery With or Without Axillary Lymph Node Dissection Followed by Radiotherapy in Patients With Clinically Node-positive Breast Cancer (TAXIS) is an ongoing, international, phase 3 surgical trial investigating noninferiority (with regard to disease-free survival [DFS], but with strong emphasis on quality of life) of axillary radiotherapy (ART) relative to ALND in the treatment of patients with cN-positive BC who undergo tailored axillary surgery (TAS).