Trial design {8}
fixatioN
BONE METASTASES, SPINAL METASTASES
The BLEND RCT is a phase III randomized controlled trial within the PRospective Evaluation of interventional StudiEs on boNe meTastases (PRESENT) cohort including patients referred to the radiotherapy or orthopedic surgery department of the University Medical Center (UMC) Utrecht for the treatment of bone metastases, according to the Trials within Cohorts (TwiCs) design [Flow chart of the study. BLEND, Stereotactic Body radiotherapy and pedicLE screw fixatioN During one hospital visit for patients with symptomatic unstable spinal metastases; PRESENT, PRospective Evaluation of interventional StudiEs on boNe meTastases; SBRT, stereotactic body radiotherapy