Randomization and Masking
depressive symptoms
Randomization was conducted by an independent statistical support service based in the United Kingdom. Randomization was stratified by severity of depressive symptoms at baseline and study center. Participants were randomized using a computer-generated, random permuted block method with variable block sizes. Allocation was masked from study investigators, assessors, participants, and their families or caregivers. All participants were assigned a unique study identification number once they provided informed consent and eligibility was confirmed. A central trial pharmacy prepared a 12-week package of 20 mg/d of simvastatin or placebo, using identical tablets. The packages bearing the participant’s identification number were sent to the site pharmacy, which was also blinded to treatment allocation.