Background

Term-born, hypoxaemia, hyperoxaemia
COMPLICATIONS
Term-born infants require respiratory support for a variety of reasons with an overall incidence of mechanical ventilation of 3.6 per 1000 live births [Ventilated neonates frequently require supplemental oxygen, but its use must be monitored carefully due to associated complications. Therefore, oxygen saturation levels (SpOMaintaining peripheral oxygen saturation levels within targets can be challenging as neonates experience frequent fluctuations and episodes of intermittent hypoxaemia or hyperoxaemia [Closed-loop automated oxygen control (CLAC) systems work through an algorithm comparing the patient’s SpOMost of the studies assessing closed-loop automated oxygen control included very preterm or low birth weight infants. Yet, more mature infants are also vulnerable to the risks related to oxygen treatment. In a randomised crossover study in ventilated infants born at or above 34 weeks gestation, we demonstrated that CLAC increased the percentage of time spent within the target range (SpOThe aim of this study is to explore if in ventilated infants born at or above 34 weeks of gestation, the use of closed-loop automated oxygen control compared to standard care reduces the overall duration of supplemental oxygen therapy and the time spent in hyperoxia. These are important outcomes related to respiratory morbidity and the complications arising from oxygen treatment. Our primary outcome is the percentage of time spent in hyperoxia (SpO