CONCLUSIONS
This is the first randomized controlled trial comparing different modalities of RRT completed in infants; our learning from previous experience of a standard crossover trial in NIDUS led to the use of SW design to address this. We had engagement and support from parents and staff due to the perceived need for this device.Largely, the results were in concordance with clinical experience of RRT in babies and with previous NIDUS animal and compassionate-use evidence (