Introduction
Sepsis, neuroinflammation, cognitive impairment, neuronal cell death, infection
SYSTEMIC INFLAMMATORY RESPONSE, SEPSIS, CIRCULATORY FAILURE, DYSFUNCTION, INFECTION, OXIDATIVE STRESS
Sepsis is a systemic inflammatory response to infection that frequently leads to multiorgan system failure, increased mortality, and long-term cognitive and functional impairment.Postsepsis cognitive impairment is postulated to result from a combination of oxidative stress and prolonged neuroinflammation that results from the initial systemic inflammatory response. Increases in reactive oxygen species induce cellular damage, which, when combined with persistent activation of microglia, can contribute to blood-brain barrier dysfunction, loss of synapses, and neuronal cell death.The multicenter, double-blind, placebo-controlled Vitamin C, Thiamine, and Steroids in Sepsis (VICTAS) randomized clinical trial was conducted between August 2018 and July 2019 to test the hypothesis that this combination therapy would improve clinically important outcomes in patients with sepsis-induced respiratory and/or circulatory failure.