Randomisation
Following confirmation of patient eligibility, receipt of informed consent and completion of all questions and data items on the randomisation form, the patient will be randomised at the level of the individual in a 1:1 ratio to either continue (GH +) or discontinue (GH −) growth hormone therapy. Randomisation will be provided by a secure online randomisation system at Birmingham Clinical Trials Unit (BCTU). A minimisation algorithm will be used within the online randomisation system to ensure balance in the treatment allocation over the following variables:Tanner stage (B2 (females) or 6– < 9 ml testicular volume of the largest testicle (males) vs B3 (females) or 9–12 ml testicular volume (males).Sex (male vs female).Participating centre.Following randomisation, a confirmatory e-mail will be sent to the responsible clinician including the child’s trial number and treatment allocation.