Study design
This study is a single-center, randomized, controlled study. The trial was performed at a tertiary medical center in Seoul, Korea between January 2021 and August 2021. Ethical approval for this study (SMC 2020-10-058-002) was provided by the Samsung Medical Center Institutional Review Board on December 3, 2020. The study was registered with the Clinical Research Information Services (CRIS identifier: KCT0005714) prior to patient enrollment on December 29, 2020. The study was conducted in accordance with the principles of the Declaration of Helsinki and the International Conference on Harmonization of Good Clinical Practice guidelines. Written informed consent was obtained from each participant and/or their legal guardian prior to inclusion.