Participants
MDD, Depression, DSM-IV-TR
MAY, DISORDERS
This study enrolled participants at the Banner University Medical Center in Tucson, Arizona, between February 2013 and May 2015. Participants were recruited via print, radio, posted fliers, email listserv, social media, and television advertising. Eligible participants were males and females, aged 18 to 65 years, who were medically healthy, met Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) criteria for MDD lasting at least 4 weeks prior to signing the consent form, and had a baseline 17-item Hamilton Depression Rating Scale (HDRS) score ≥16. All participants were free of psychotropic medications at the time of signing consent and remained off these medications during study participation. A full list of inclusion and exclusion criteria, as well as relevant demographics for the study population, has been provided previously [