Ethical approval
RECRUITMENT
This study was approved by the Institutional Review Board of Seoul National University Hospital (approval number: 1806-039-949, date: July 10, 2018) and registered in the Korean national registry of clinical trials before patient recruitment (number: KCT0003225, registration date: 28/09/2018), All patients provided written informed consent. We conducted this study in accordance with the Helsinki Declaration and the Good Clinical Practice guidelines and reported the findings based on the applicable Consolidated Standard of Reporting Trials guidelines. A reporting guideline checklist is included in the 