Therapeutic mechanisms of CBD
depression, psychiatric, anxiety
DISORDERS
Despite interest in the potential medicinal uses of CBD [The endocannabinoid system consists of cannabinoid type 1 receptors (CB1Rs), type 2 receptors (CB2Rs), and endocannabinoid ligands that bind to these receptors such as anandamide and 2-arachidonoylglycerol (2-AG) [Like CBD, the endocannabinoid system has been implicated in a range of psychiatric disorders. In mouse and rodent models, the experimental elevation of anandamide via exercise or inhibition of FAAH resulted in anxiolytic effects, which were then nullified by CB1R blockade [In addition to anxiety and depression, the endocannabinoid system plays a key role in addiction [