Introduction
toenail onychomycosis, onychomycosis
FUNGAL NAIL INFECTION, DISEASE, ONYCHOMYCOSIS, SEPARATION, ONYCHOMYCOSIS
Fractional photothermolysis is considered a significant technological advance in dermatology. In fractional lasers, the laser beam is split into a pattern of microbeams. This results in thermal microscopic wounds into deep skin structures [Onychomycosis is a fungal nail infection often with thickening, discoloration and separation from the nail bed, being more common in the elderly [In view of the limited efficacy of traditional therapies along with its high prevalence, it is needed to explore new and more effective alternative therapies in treating the disease. Lasers are an innovative technology for the treatment of moderate onychomycosis [Moreover, studies involving the use of urea as a therapeutic option for onychomycosis have been newly reviewed [Based in these considerations, a controlled short- and medium-term controlled clinical trial is proposed to assess and compare the efficacy of a pretreatment with urea with another pretreatment based in fractional Er:YAG laser (Fr Er:YAG) radiation before PDT mediated by methylene blue (MB/PDT) for moderate toenail onychomycosis.