Trial design
This study was a single-centre, randomized placebo-controlled, double-blind trial. The experiment was completed in The First People’s Hospital of Changde City. The trial was supported by the Scientific Research Project of Hunan Provincial Health Commission (project number: 202,204,114,103) and the research project of “Wings Research Fund” of The First People’s Hospital of Changde City (project number: 2022ZZ06). There was no commercial participation in the experiment. The Medical Ethics Committee of The First People’s Hospital of Changde City conducted the ethical review throughout the process and approved the program (approval number: 2021-265-02). Meanwhile, the program was also registered in the Chinese Clinical Trial Registry (16/1/2022, registration number: ChiCTR2200055683). The study was conducted with the written informed consent of the patient or the patient’s authorized person and in strict accordance with the Declaration of Helsinki and clinical practice guidelines. The author can guarantee the accuracy, completeness and authenticity of all data obtained.