Concentrations of EVG, TAF and TFV in plasma
Systemic concentrations of EVG were low but detectable in plasma at 4 hours post-dose, were higher at 24 hours post-dose (mean 0.33 ng/mL), and then were markedly lower by 48 hours and 72 hours post-dose. At 72 hours post-dose, 6 of 7 participants had BLQ plasma EVG levels. Similarly, the mean plasma concentration of the prodrug TAF was highest at 4 hours post-dose (mean 1.03 ng/mL), then lower by 24 hours (4 of 8 participants BLQ), 48 hours (7 of 8 participants BLQ), and 72 hours (7 of 7 participants BLQ) post-dose. Levels of TFV were detectable in plasma for most participants by 4 hours post-dose. TFV concentrations were higher at 24 hours post-dose (mean 0.48 ng/mL), decreasing by 48 hours and 72 hours post dose.