Relationship between vessel lumen diameter and CBF exercise intervention changes
This exploratory analysis showed that an increase in ICA lumen diameter between study visits was associated with an increase CBF in the exercise intervention group in the left and right lateral parietal lobe (Top: voxel-wise positive association between change in vessel lumen diameter and ASL parameters with exercise, significant voxels indicated in red. Bottom: perfusion change averaged over the significant voxels plotted against the change in ICA lumen diameter (bottom). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)There were no significant associations between MCA M1 lumen diameter and CBF changes over the exercise intervention period. The association between the change in ICA lumen diameter and perfusion is still significant when examined with a non-parameteric Spearman test (S(29) = 3074, ρ = 0.04, p = 0.04).