Conclusion
ADHESION
Within the limitations of this study, which, to the best of our knowledge, is the first study that evaluated the clinical and biochemical significance of RGD hydrogel in periodontal regeneration, we can conclude that the use of RGD peptide-loaded hydrogel could be an effective treatment option that improved periodontal regeneration. MIST could be important in maintaining RGD peptides and autogenous growth factors levels within the defect area for more positive outcomes. More studies are required to evaluate the minimum amount of RGD molecules required to get the maximum effect on cellular adhesion.