Fc receptor binding and Fc-effector function induction by Ad26.RSV.preF alone and the Ad26.RSV.preF/RSV preF protein combination vaccine
ADNKA
RSV INFECTION
Both pre-existing and vaccine-induced RSV preF-specific antibodies demonstrated binding to Fc receptors FcγR2a, FcγR2b, FcγR3a, and FcγR3b and induction of Fc-effector functions (RSV preF-specific FcγR binding and Fc-effector functions induced by Ad26.RSV.preF and the Ad26.RSV.preF/RSV preF protein combination vaccine. RSV preF-specific FcγR binding and Fc-effector functions were measured in serum samples collected on days 1 (pre-vaccination), 15, 29, and 183 from participants receiving Ad26.RSV.preF alone (Despite pre-exposure to RSV infection, substantial ADCD, antibody-dependent neutrophil phagocytosis (ADNP), and ADNKA responses were not observed at baseline, suggesting that responses measured post-vaccination were 