Secondary Outcomes: EU(7)-PIMs at Baseline and After 6 and 12 Months in the Per-Protocol Population
REGRESSION
Abbreviations: EU(7)-PIM, European Union list of the number of potentially inappropriate medication; IRR, incidence rate ratio.The EU(7)-PIM for older people.Mixed-effect Poisson regression model adjusted for the number of EU(7)PIMs at baseline. Practices were taken into account as a random effect.The application of a mixed regression model (model 1 mixed-effect Poisson regression) with adjustment for the number of medications at baseline (T0) as well as taking GP practices into account as a random effect resulted in a significant group difference between the intervention and control arms at T1 (IRR, 0.88; After 6 months, the mean (SD) number of EU(7)-PIMs was significantly lower in the intervention group (1.30 [1.05]) than in the control group (1.71 [1.25]; The results for the assessments and safety parameters after 12 months are reported in the eTable in During the course of the study, a total of 59 (11.3%) of the 521 participants examined at baseline died within the 12-month observation period (intervention, 29 of 272 [10.7%]; control, 30 of 249 [12.0%]). There was no statistically significant difference between the groups with regard to mortality (