fMRI statistical analysis
INSULIN SENSITIVITY
The individual data sets were preprocessed before running statistical analyses using tools from the FMRIB Software Library (FSL version 5.08, Statistical analyses were conducted using Statistical Parametric Mapping version 12 (r6225, Wellcome Trust Centre for Neuroimaging) implemented in MATLAB R2019b (MathWorks) in the framework of a GLM. At the single-participant level, conditions were modelled using a boxcar reference vector convolved with the canonical hemodynamic response function and its time derivativeAt the second (group) level, we specified a GLM to investigate the effects of insulin sensitivity and intervention on adaptive prediction error neural encoding. In a flexible factorial design, the factors participant, group (normal insulin sensitivity (IS