Trial hypothesis
BPD, death
We hypothesized that the use of a LUS to quantify RDS severity and guide surfactant treatment (study group) may increase the proportion of preterm infants receiving timely SRT and eventually improve their short- and long-term outcomes in comparison with a control group treated according to the FiOTherefore, our hypothesis is that the study group will show a decrease in the proportion of infants affected by BPD or death.To confirm this hypothesis, we planned an international multi-center randomized controlled study in which preterm infants are randomized into two groups: one will receive SRT based on the FiOThe study flow chart is detailed in Fig. Study flow chart