Author contributions
P.Z., and D.B. conceived and designed the study. W.H., L.D., D.Z., and N.S. provided the materials and patients support. G.J. and Y.Z. provided the administrative support. D.B., H.X., X.Z., F.S., Y.X., Z.H., Y.H., D.Z., J.Y., X.B., W.W., and J.Huang. collected the data. D.B., L.S., J.Hu., and L.Z. analyzed and interpreted the data. D.B. and L.S. wrote the first draft of the manuscript. All authors approved the final version of the manuscript for submission.