Study approval.
All animal experiment protocols were approved by the Ethical Committee of Stockholm and conform to the Guide for the Care and Use of Laboratory Animals published by the United States National Institute of Health (NIH publication No. 85-23, revised 1996). All procedures involving humans were conducted according to the Declaration of Helsinki. The protocol was approved by the Swedish Ethical Review Authority for human studies. All participants were informed of the study’s purpose and gave their oral and written informed consent before any study-related procedures were initiated.