Morbidity Outcomes (Fatal and Nonfatal Events)
nonfatal stroke, death, cancer of any type, stroke, ESRD, Cancer
RENAL, CVD, STROKE, SECONDARY, EVENTS, EVENTS, ESRD, CANCER
Nonfatal events were defined by hospitalization due to a prespecified cause. Except for ESRD, the availability of nonfatal outcome data was limited to participant medical records originating from US clinical centers unaffiliated with Veterans Affairs (VA) that were linked to valid Medicare or Social Security numbers. Therefore, participant medical records originating from VA sources (n = 5558) and non-Medicare participants (n = 4492) were excluded from long-term morbidity follow-up. Events that occurred during the in-trial period were ascertained and classified by investigators and confirmed by discharge summaries. Information on ESRD events (chronic dialysis or kidney transplant) that occurred during the in-trial period was gathered from the United States Renal Data System (USRDS) database through 2006. Data on posttrial morbidity outcomes were gathered from the CMS and USRDS databases. Classification of events identified through CMS data was accomplished using The following morbidity outcomes were prespecified as secondary end points: fatal or nonfatal CVD (death or hospitalization due to MI, stroke, or HF), fatal or nonfatal CHD (death or hospitalization due to CHD), fatal or nonfatal stroke (death or hospitalization due to stroke), fatal or nonfatal HF (death or hospitalization due to HF), and fatal or nonfatal ESRD (death or hospitalization due to ESRD). Cancer mortality and morbidity (death or hospitalization due to cancer of any type) were included as additional outcomes of interest.