As-observed analysis (included all data after taking selected prohibited and/or rescue medications)
Data collected after taking all prohibited medications and/or rescue medications were included in the supplementary analysis to evaluate the robustness of the primary analysis results with respect to the method of handling data while taking selected prohibited/rescue medications (for example, treatment policy strategy). In addition, for patients discontinuing the study treatment before week 12 (or 24), their off-study treatment values measured up to week 12 (or 24) were included in the analysis. The patients having missing data at week 12 (or 24) regardless of reason(s) were considered non-responders at that timepoint (Extended Data Table 