Endpoints
PD, death, SD
DISEASE, SECONDARY
The primary endpoint was PFS, which defined as the time from enrollment to PD per RECIST 1.1 criteria or death from any cause, whichever occurred first. The secondary endpoints included OS (defined as the time from enrollment to death from any cause), disease control rate (DCR, defined as the percentage of patients with a complete response [CR], partial response [PR] or stable disease [SD]), ORR (defined as the percentage of patients with a CR or PR), and duration of response (DoR, defined as the time from the first document CR or PR to PD or death from any cause). The safety profiles included treatment-related AEs (TRAEs) and immune-related AEs (irAEs).