Conclusions
depressive disorder, Message-based, RA
This randomized controlled trial supports the treatment efficacy and acceptability of asynchronous message-based psychotherapy for major depressive disorder. Message-based psychotherapy also appears to be noninferior to the more widely accepted remote modality of video-based psychotherapy. Given its lower burden and greater accessibility compared to traditional psychotherapy, asynchronous message-based psychotherapy holds a promising avenue for future research and implementation.This study used REDCap hosted at the Institute of Translational Health Sciences, which is supported by the National Center for Advancing Translational Sciences of the National Institutes of Health under Award Number UL1 TR002319.Conflicts of Interest: TDH and BL were employees of the service. JS, RA, SC, and PAA declare no conflicts.CONSORT-eHEALTH checklist (V 1.6.1).