Ethics approval
Ethical and operational approval was obtained from the Health Research Ethics Board at the University of Alberta (Pro00067811 and Pro00069064), the Health Research Ethics Board of Newfoundland & Labrador (#2017.027, 2017.027B, 2017.027C, 2017.027D and 2017.284), the Markham-Stouffville Hospital Research Ethics Board (no file number assigned) and the Research Ethics Board at St. Michael’s Hospital (#17-050 and #17-248). All analyses were performed in accordance with the relevant guidelines and regulations.