Sample Size Estimation
RECRUITMENT
The sample size was calculated to compare 2 independent sample means and detect a difference of 0.5 in the NCQ TCC score (SD 0.75), with 80% power and a 2-sided α of 5%. The minimum number of patients required per group was 37. Considering the potential loss to follow-up, the aim was to recruit an additional 7 patients, with a recruitment target of 44 patients per group or 88 for each of the treatment and survivorship phases (176 patients in total; eOncoNote trial schema.