Hypotheses
neutropenic, fever of infectious
The use of oral fosfomycin is not inferior to oral ciprofloxacin in the prevention of fever of infectious origin in high-risk neutropenic patients. This hypothesis is based not only on the broad-spectrum activity of fosfomycin but also on the low rate of resistance to this drug. In addition, we anticipate that the clinical efficacy of fosfomycin will be accompanied by an acceptable safety profile. Thus, there is potential for fosfomycin to be useful as a prophylactic agent in settings endemic for GNMRB.