Exploratory outcomes
stroke, arrhythmia
STROKE, MYOCARDIAL INFARCTION, ARRHYTHMIA

All-cause mortalityComposite of all-cause mortality, stroke, myocardial infarction, and cardiac arrestStrokeHospitalization for worsening of heart failureNumber of hospital admissions, analyzed as count dataSix-minute walking distanceHealthcare costs (will be further defined and reported in separate publications)Various biomarkers (N-terminal pro-brain natriuretic peptide (nt-proBNP), high-sensitivity C reactive protein (hsCRP), high-sensitivity troponin I (hsTnI), growth differentiation factor-15 (GDF-15), interleukin 6 (IL6), cystatin-C, YKL40, soluble urokinase plasminogen activator receptor (suPAR), and fibulin-1Switch to rhythm control strategy (such as rhythm control medication, direct current-conversion or pharmacological cardioversion, pulmonary vein isolation, or arrhythmia surgery)Implantation of a pacemaker or cardioverter-defibrillator with or without atrioventricular nodal ablation