Conclusions
T1D, atrophy, AD-related neurodegeneration, Brain atrophy
ATROPHY, BRAIN ATROPHY
The findings of this cohort study suggest that individuals with T1D show an acceleration of brain aging without any early signs of AD-related neurodegeneration. Regional atrophy is most pronounced in the thalamus. Brain atrophy is linked to changes in cognition, but overall, the differences seen in middle-aged to older-aged adults with T1D compared with controls without T1D were modest, even after more than a mean of 38 years of T1D.