2.4. Inhibition of TG2 by ZED1227 in a Lamina Propria-Free Intestinal Organoid Model
We next studied the expression and localization of TG2 and ZED1227 in human intestinal epithelial organoids that are devoid of lamina propria. The staining results of TG2 protein were similar to those obtained from clinical biopsies, with prominent deposition on the organoid epithelial cell surface (