Efficacy endpoints
nocturnal back pain, pain
ENTHESITIS, ANKYLOSING SPONDYLITIS, DISEASE, REMISSION, DISEASE
The following endpoints were assessed through week 52: the percentage of patients achieving ASAS40 response, AS Disease Activity Score (ASDAS) using C-reactive protein low disease activity (LDA; < 2.1), ASDAS inactive disease (ID; < 1.3), ≥ 50% improvement in BASDAI (BASDAI50), ≥ 20% improvement in ASAS response (ASAS20), ASAS partial remission (PR; absolute score of ≤ 2 units for each of the four domains of ASAS40); change from baseline in linear Bath Ankylosing Spondylitis Metrology Index (BASMI), Maastricht Ankylosing Spondylitis Enthesitis Score (MASES), ASAS Health Index (HI), Ankylosing Spondylitis Quality of Life (ASQoL), patient’s assessment of total back pain and nocturnal back pain (numeric rating scale 0–10), and Bath Ankylosing Spondylitis Functional Index (BASFI). Additional efficacy endpoints are listed in Supplementary Table 