Antitumor Responses
toxicity, melanoma
DISEASE, MELANOMA
Of the 18 patients, there were eight partial responses (PR) and two complete responses (CR; Swimmer plot showing time on study. Patients are grouped by dose level. Red bars indicate patients who had a CR; blue bars are patients with a PR. Black bars indicate patients with no response. Patients who had received prior treatment with RAF inhibitors are indicated with an asterisk. The reason for treatment discontinuation is indicated to the right of each bar. POD, progression of disease; TOX, toxicity. Patient 6 underwent complete resection of residual melanoma and was then taken off study.