Metabolomic and lipidomic changes associated with pre-eclampsia
pre-eclampsia
PRE-ECLAMPSIA, APPENDIX
Out of 174 women who gave samples for metabolite profiling, 20 developed pre-eclampsia, of whom 12 had cord blood available (ESM Appendix In maternal blood at 12 weeks, two TAGs were positively associated with pre-eclampsia. At 24 weeks, N-acetylhistidine, orotidine and nine individual PEs (containing FA[16:0], FA[18:0) or FA[18:1]) in maternal blood were associated with pre-eclampsia. At 34 weeks, there were positive associations between pre-eclampsia development and several amino acid derivatives, polyamines and an endogenous or exogenous pentose alcohol (arabitol or xylitol).