Treatment allocation
LYMPHEDEMA
Enrolled participants were allocated randomly and in equal numbers into one of three treatment groups by a sealed envelope method (Study flow diagram.Group A received one treatment per day for 12 consecutive days. The first five treatments were administered in clinic followed by two patient-administered treatments at home (Saturday and Sunday) for participant convenience, concluding with an additional five in-clinic treatments (12 total hours of treatment).Group B received two in-clinic 1-hour treatments per day (Group C received two consecutive 1-hour in-clinic treatments two times per day (In participants with bilateral lymphedema, the leg with the largest volume was studied. Treatment of contralateral legs was maintained as it had been before the study. Investigators used a pressure measuring device (PicoPress; Microlab Elettronica Sas, Padua, Italy) to ensure uniform application of the device across all participants before inflation (7–10 mm Hg).