1. Introduction
dermal pain, idiopathic generalized anhidrosis, pain
CHOLINERGIC URTICARIA, ERUPTIONS, PATHOGENESIS, HYPOHIDROSIS
In a certain population of individuals, the exposure to sweating stimuli such as bathing, exercise, or mental stress, leads to severe dermal pain.Despite numerous attempts to treat sweating-induced dermal pain, no standard treatment has been established. Common nonsteroidal anti-inflammatory and analgesic drugs demonstrate little effect. As the condition frequently presents with transient eruptions and/or generalized hypohidrosis, antihistamines and systemic corticosteroids have been tested based on their effectiveness against cholinergic urticaria and acquired idiopathic generalized anhidrosis.The precise pathomechanisms underlying sweating-induced dermal pain remain elusive. Short duration of the pain following sweating stimuli suggests the involvement of endogenous pain-producing substances with short lifetimes, such as histamine and bradykinin in the pathogenesis of sweating-induced dermal pain. High levels of histamine in sweat and elevated plasma histamine levels after thermal sweating in patients with dermal pain compared to healthy subjectsThis study aims to evaluate the analgesic effect of icatibant, a bradykinin B2 receptor antagonist, on patients experiencing sweating-induced dermal pain and to demonstrate a role of bradykinin in the pathomechanism of dermal pain. Its results are expected to contribute to the development of novel treatments for sweating-induced dermal pain targeting bradykinin and the kallikrein-kinin pathway.