Statistical Analysis
All analyses were performed by intention to treat. Baseline characteristics are reported as percentages for discrete variables or mean (SD) and/or median (25th–75th percentiles) for continuous variables.Statistical analyses of the AFEQT and MAFSI end points follow the same methods as the primary CABANA QOL report.Point estimates for each treatment group as well as treatment group mean differences (ablation, drug therapy) with 95% CI were generated using the ESTIMATE Statement with the SAS PROC MIXED procedure. No adjustments were made in the analyses for multiple comparisons. Instead, we limited the number of formal statistical tests reported and focused primarily on the estimated treatment effect sizes and associated precision. Prior QOL analysis in CABANA used post hoc baseline AFEQT scores subgroups <70, 70 to 89, and ≥90 to identify severely symptomatic, mildly to moderately symptomatic, and asymptomatic patients with AF, respectively, to examine whether treatment response magnitude at 12 months was affected by baseline scores.AFEQT and MAFSI outcomes are reported by treatment group and sex both overall and according to the AFEQT subgroups expressed as mean difference (ablation minus drug therapy) with 95% CI. Results are displayed as bar graphs and histograms (unadjusted) as well as forest plots (adjusted mean difference).All analyses were performed using SAS software version 9.4 or later (SAS Institute).