INTRODUCTION
hyperlipidemia
HYPERLIPIDEMIA
The rapid development of the world economy has dramatically changed people's living standards and diet structure, and the fast-food diet structure has also led to an obvious increase in the proportion of high-fat foods in the daily diet (Several studies have found a link between hyperlipidemia and human gut microbiota, for example, significant differences in the gut microbiota profile between hyperlipidemic and healthy individuals (including animals) (Wang et al. found that feeding animals with high-fat diets disrupted both the host’s antioxidant capacity and gut microbiota balance, ultimately leading to the exacerbation of hyperlipidemic symptoms (This study hypothesized that probiotics could regulate the gut microbiota balance in hyperlipidemic patients and improve hyperlipidemic symptoms via modulating the host lipid metabolism. In this 3-month intervention trial, a total of 56 hyperlipidemic patients were recruited and randomized into the placebo and probiotic (receiving a mixed probiotic formulation) groups. The fecal microbiome and serum lipids of these patients were analyzed using metagenomics and liquid chromatography–mass spectrometry (LC-MS), respectively. Meanwhile, changes in patients’ physiological and biochemical parameters were recorded. This study confirmed the beneficial effect of Probio-X in managing hyperlipidemia.