Statistical methods
Descriptive statistics were used to summarize demographic and clinical data. Categorical data are shown as numbers and percentages, and continuous data are given as median (minimum, maximum). Repeated measures analysis of variance (ANOVA) with multiple comparison by the Bonferroni method was used to compare the primary outcome between and among the three different interventions at different time points. All statistical analyses were performed using a SPSS Statistics version 18.0 (SPSS, Inc., Chicago, IL, USA), and a 