Introduction
cancer, tumor
CANCER, TUMOR, SOLID TUMORS, TUMOR VASCULATURE
Eribulin is a halichondrin-class microtubule dynamics inhibitor with cytotoxic and vascular remodeling effects leading to tumor immune modulation (Liposomal formulations can be used to improve the access of anticancer treatment into tumor cells by increasing their ability to permeate tumor vasculature (E7389-LF monotherapy has shown responses in several cancer types; specifically, in the dose-escalation part of a phase I study (Study 114) enrolling 21 patients with solid tumors in Japan (Chemotherapies such as eribulin have potential to provide synergistic antitumor effects through the programmed cell death-1 (PD-1) pathway when combined with immune checkpoint inhibitors (ICI; refs. In this study, we sought to determine a recommended phase II dose (RP2D) of E7389-LF in combination with nivolumab (