Randomization
All participants were randomly assigned into study groups of cases and controls using the permuted block randomization method with a random block length of 2, 4, 6, and 8. The randomization list was generated by a computer-based program and the details of the random sequence were concealed from researchers. Whenever a new patient entered the study a new envelope (which contained the group for the order sequence of the patient) was opened and the group was revealed. Participant enrollment and intervention assignment were carried out (HM, HE, and AR).