THE PARTICIPANTS
Although a formal study of reasons for nonparticipation was not conducted, discussions revealed that potential participants did not feel at risk of contracting COVID-19. Yet, the later acceptance of vaccination was much more pronounced than the acceptance of participating in the trial with HCQ, suggesting that nonparticipation may have been motivated more by unwillingness to use the experimental product—whether because of controversy around its use or the necessity for strict adherence to the protocol requiring daily intake during 90 days—than by other factors.In addition, the poor enrollment can also be explained by the participants’ desire to receive what was felt to be appropriate compensation for their participation in the research. This is called 