Cortisol dynamic and glycemic status
±, Diabetic, diabetic, Pre-diabetic, diabetic and pre-diabetic, weight loss, diabetes
PRE-DIABETIC, TYPE 2 DIABETES, PRE-DIABETIC, DIABETES
We further examined FMC changes from three glycemic states at baseline: Normoglycemic(Baseline FMC=285.44 ± 85.44 nmol/L), Pre-diabetic (Baseline FMC=320.65 ± 90.52 nmol/L), Diabetic (Baseline FMC=325.65 ± 92.5 nmol/L). At baseline diabetic and pre-diabetic groups had higher FMC levels than the normoglycemic group(p<0.05 for both). After 6-months (Normoglycemic=308.28 ± 106.44 nmol/L, pre-diabetic=319.28 ± 112.04 nmol/L, diabetic=370.8 ± 134.3 nmol/L), the group of probands with type 2 diabetes showed the greatest elevation (19%± 42.9% [50.37 ± 114.40 nmol/L], p=0.01 vs. baseline), as compared to the pre-diabetic (4.8% ± 42% [-0.70 ± 112.7 nmol/L], p=0.94 vs. baseline) and normoglycemic (13.7%± 40.6% [22.56 ± 105.15 nmol/L], p=0.02 vs. baseline) groups (p<0.05 for difference between groups; in multivariable models adjusted for age, sex, and 6-month weight loss). After 18-months (Normoglycemic=276.32 ± 88.38, pre-diabetic=291.8 ± 86.56 nmol/L, diabetic=299.42 ± 88.41 nmol/L), only the pre-diabetic group exhibited a statistically significant reduction in FMC levels vs. baseline (-3.9% ± 33.6% [-28.9 ± 100 nmol/L]; p<0.01), whereas the diabetic and normoglycemic groups showed a non-significant change vs. baseline (-4.7% ± 29%[-30.12 ± 117.6 nmol/L]; p=0.17; (5.1%± 51.7% [-8.13 ± 102.77 nmol/L]; p=0.36; respectively). Further details are illustrated in Fasting morning cortisol changes across glycemic-status groups. 1. FMC changes across glycemic status groups (defined at baseline) by time, Baseline, 6-months and 18 months (end of intervention). 2. Diabetic defined as fasting glucose >=126 or HbA1c >=6.5 or receiving medical treatment for diabetes. 3. Pre-diabetic defined as 126>fasting glucose >=100 or 6.5>HbA1c>=5.7. 4. P between groups was analyzed in an ANCOVA model adjusted for Δweight, age, and gender. 5. * Significant (p<0.05) within change vs. baseline at 0.05; Diabetic and normoglycemic groups had significantly elevated FMC levels in 6-months and pre-diabetic groups had significantly reduced FMC levels.Participants were classified into three groups by their transition from three glycemic status groups [Normoglycemic[n=148, mean weight=91.11 ± 13.01 kg, fasting glucose=91.94 ± 5.55 mg/dL, HbA1c=5.19% ± 0.31%], Pre-diabetic[n=110, mean weight=96.13 ± 16.14 kg, fasting glucose=106.51 ± 7.34 mg/dL, HbA1c=5.51% ± 0.34%], Diabetic[n=32, mean weight=96.36 ± 12.41 kg, fasting glucose=147.16 ± 46.73 mg/dL, HbA1c=6.75% ± 0.97%]; glycemic status groups were defend using ADA definition (Fasting morning cortisol and shifting of glycemic-status. 1. 