Ethics approval and consent to participate
Ethics approval was granted by the Colorado Multiple Institutional Review Board (COMIRB #22–2423 and #23–0109). Written informed consent will be obtained from all patients and their legal guardian(s). Written assent of pediatric patients will also be obtained using an assent form for children ages 7–12 years old and a joint assent-consent form for children ages 13–18 years old. All experiments will be performed in accordance with relevant guidelines and regulations including the Declaration of Helsinki.