Statistical analysis
Descriptive statistics were used to describe the study population using mean, standard deviation for continuous variables and frequency and percentages for categorical variables. The normality of the continuous variables was checked and confirmed using Shapiro–Wilk tests. To account for dependencies of the measured metrices, we used paired t-tests to compare the stability, suspension, and comfort scores using Comprehensive Lower Limb Amputee Socket Survey (CLASS), perceived sweat, and relative humidity AUC between nVS and VS systems. For the 2 × 2 crossover design, using Analysis of Variance (ANOVA) we evaluated inter- and intra-subject variabilities, sequence, period, and treatment effects if no carryover effects exist. One-tailed t-test was performed because the primary outcome hypothesis tested was effect on effective mitigation/decrease of sweat within liner. All statistical testing and analysis were done using Stata/MP 16.1.