Study design
inflammation, FMNST
INFLAMMATION, PERIODONTITIS
This study was set to investigate the effect of Metformin on acute systemic inflammation during Periodontal Treatment in healthy non-Diabetic patients. Twenty patients in good health and diagnosed with Generalized Periodontitis stage 3 or 4 Grade B or C, requiring for non-surgical periodontal treatment were selected to participate in the trial. The volunteers were randomized into two groups: control group (Placebo, n = 10), test group (850 mg oral Metformin, n = 10). Participants were instructed to start the administration of medication (1 oral tablet) once a day, orally, in the morning at breakfast, 3 days before periodontal treatment and after blood and gingival crevicular fluid (GCF) collection for baseline laboratory tests. Full mouth non-surgical treatment (FMNST) was provided to the participants on the third day of medication. During treatment, the granulation tissue of the deepest periodontal pocket was collected. After treatment, the medication was prescribed once a day, orally, in the morning at breakfast, for 7 days, similarly to the prescription course of antibiotic therapy. In total participants had 10 days of either Placebo or 850 mg Metformin (Additional file 