D2/3 transmission in the fronto-subthalamic pathway
CORTEX
A novel finding is that D2 receptor activation can downregulate the maintenance-related STN and dlPFC activity and dlPFC activity pattern similarity but upregulate the manipulation-related STN and dlPFC activity and fronto-subthalamic functional connectivity. Although the STN and frontal cortex have a much lower density of D2 receptors than the striatum [Mechanisms underlying the observed maintenance-related activity downregulation and manipulation-related activity upregulation remain unclear. For the prefrontal cortex, the maintenance-related activity change may result from decreased regional cerebral blood flow. Black et al. [Futhermore, D2 transmission can modulate membrane resonance of STN neurons and high-voltage spindles (HVSs) in the fronto-basal ganglia loops. Yang et al. [