Olink Proteomics and Multiplex.
INFLAMMATION
Inflammation panel comprising of 96 protein biomarkers (Olink Proteomics) was used on serum samples of patients at baseline (day-2) and day 10. Data from the analyzed protein biomarkers was presented in normalized protein expression (NPX) values, Olink Proteomics’s arbitrary unit on log2 scale. Cytokine/Chemokine/Growth Factor Panel (EPX450-12171-901) in serum samples in patients treated with Foralumab, untreated control, and healthy controls. Assay was performed by The Cytokine Core, LLC according to the manufacturer’s instructions. Markers were BDNF, EGF, Eotaxin, FGF-2, GM-CSF, GRO-α*, HGF, IFN-α, IFN-γ, IL-1RA, IL-1α, IL-1B, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12(p70), IL-13, IL-15, IL-17A, IL-18, IL-21, IL-22, IL-23, IL-27, IL-31, IP-10, LIF,MCP-1, MIP-1α, MIP-1β, NGF-β, RANTES, PDGF-BB, PIGF-1, SCF, SDF-1α, TNF-α, TNF-β, VEGF-A, VEGF.