2.1. Study Design
pruritus
This was a single-blind, parallel randomized controlled trial (RCT) assessing the effectivity of Severity of AD was measured using the SCORAD index, ranged from 0–100. Meanwhile, pruritus intensity was measured by subjective symptom of SCORAD with visual analog scale average for the last 3 days. The serum IL-3 level was measured using an ELISA IgE kit, and was measured in IU/mL. The formation of This study had been registered into the Thai Clinical Trials Registry, registration number TCTR20231025004. Moreover, this study was also approved by the Ethics Committee of the Faculty of Medicine, USK—Dr. Zainoel Abidin General Hospital, Banda Aceh (Ethical Approval Number: 157/EA/FK-RSUDZA/2021). Prior to data collection, patients’ parents or caregivers were given an explanation about the study procedure, benefit of the study and possible side effects. Signed informed consents from the parents/caregivers who were willing to participate in the study.