Population cohort study: metformin interaction with LVH risk SNP rs9838915
Diabetes Audit, diabetes, LVH, KLF-15
RECRUITMENT, LEFT VENTRICULAR HYPERTROPHY, INTERACTION, REGRESSION, LVH, DIABETES
Patients were derived from the Genetics of Diabetes Audit and Research Tayside Scotland (GoDARTS) study, the methods and cohort details have been described in full previously [In this study we included all DM cases and excluded non-DM controls. Patients were stratified by genotype related to Kruppel-like factor 15 (KLF-15) (rs9838915) which we have previously shown is significantly associated with echocardiographic left ventricular hypertrophy (LVH) [Logistic regression was used to determine the association of KLF-15 genotypes (GG vs. GA vs. AA) with presence of LVH with adjustment for age, gender, diabetes status, systolic blood pressure and BMI. Interaction testing was performed to determine whether the association of rs9838915 with LVH was different in those patients using metformin at the point of recruitment into the GoDARTS study. We used Angiotensin Converting Enzyme (ACE) inhibitors or Angiotensin II Receptor Blockers (ARB) use as a control group. A 2-sided p value of <0.05 was considered significant and analysis was performed using R version 3.4.3.