Study design
We conducted a randomized, single-blind, multicenter phase II trial to determine the effects of one or two intracoronary infusions of umbilical cord Wharton’s jelly tissue-derived MSCs on post-AMI LVEF when added to standard management. The Ethics Committee of Shiraz University of Medical Sciences approved the study protocol (IR.SUMS.REC.1399.406), which is registered with the Iranian Registry of Clinical Trials (IRCT20201116049408N1). Written informed consent was obtained from all patients before participation once they were in stable condition and recovered from the influence of sedatives. An independent Data and Safety and Monitoring Board (DSMB) monitored patient safety during the study. In-depth details regarding the study protocol are available in a previous publication [CONSORT flow diagram of the study