Ethics approval statement for human studies
The study was conducted according to the latest revision of the Declaration of Helsinki and was approved by the Ethical Committee of the Social Insurance Institution of Finland. This work was supported by the Emil Aaltonen Foundation [to T.N.], the Paavo Nurmi Foundation [to T.N.], the Finnish Medical Foundation [to T.N.], the Finnish Foundation for Cardiovascular research [to T.N.] and Academy of Finland [321351 to T.N.; 129479 to I.E., 141136 to S.J. and M.S.].