Introduction
diabetic retinopathy, diabetic nephropathy
DIABETIC RETINOPATHY, DIABETIC NEPHROPATHY, DIABETIC COMPLICATIONS, CAPILLARY DISEASE
Calcium dobesilate is a kind of vasodilator selectively acting on the capillary wall, which can not only adjust and improve the permeability and brittleness of the capillary wall but also inhibit bradykinin and other active substances, mainly used for the treatment of capillary diseases caused by a variety of reasons [Calcium dobesilate is often used in clinical treatment for some diabetic complications, such as diabetic retinopathy and diabetic nephropathy [Although the branded drug of calcium dobesilate (Doxium) has been on the market for many years, it is still high-cost for some patients. Therefore, the approved generic product of calcium dobesilate is needed to support the marketing application and help relieve the medical cost burdens. Bioequivalence studies comparing generic to innovator products are required for marketing a new generic product by the National Medical Products Administration (NMPA) of China [Pharmacokinetic (PK) properties and bioequivalence of calcium dobesilate in different dosage forms by different manufacturers have been studied before, including in Chinese subjects [