Author contributions
LZ, LC, and QX designed the research, analyzed and interpreted the data, performed the statistical analysis, drafted the manuscript, and incorporated feedback from all authors. ML and HL coordinated and managed study data acquisition. LZ, ZS, and HL examined all the specimens and collected clinical data. ZG, YG, HZ, and FQ collected clinical specimens, supervised data acquisition, and analyzed and interpreted data. WC co-conceptualized the study, designed the research, and revised the manuscript. All authors contributed to the article and approved the submitted version.