Exclusion criteria
ER-negative DCIS, tumor, unstable arrhythmia, unstable angina pectoris, Cardiac Disease Grade II, non-melanomatous skin cancerEvidence, palpable, neoplasm, cardiac disease, necrosis, ER-positive
TUMOR, MYOCARDIAL INFARCTION, COMEDO, UNSTABLE ANGINA PECTORIS, DCIS, CERVICAL INTRAEPITHELIAL NEOPLASIA, CEREBRAL STROKE, NEOPLASM, CARDIAC DISEASE, NECROSIS, PATHOLOGY

Known Women whose DCIS is palpable at the time of diagnosis, multicentric (mammography), mass (mammography), or bloody nipple dischargePathological characteristics:Lesions measuring >2.5 cm in the greatest dimension on pathology specimensHigh-grade lesions or low- to intermediate-grade with comedo or necrosis classified according to the Pathologic Guidelines [Margins, as assessed by the ink method, were < 3 mm.ER-negative DCIS or ER-positive percentage < 10% in tumor cellsPost-mastectomy patients.Prior diagnosis of neoplasm within 5 years, except for cervical intraepithelial neoplasia 1 or localized non-melanomatous skin cancerEvidence of clinically significant cardiac disease, as defined by cardiac disease (New York Cardiac Disease Grade II), history of myocardial infarction, cerebral stroke, unstable arrhythmia, and unstable angina pectoris within 12 months before study entry