Trial design
Figure Experimental schematic. A muscle biopsy was taken prior to the beginning of any treatment (PRE) or intervention. Participants were then given placebo or metformin for 2 weeks and stopped taking their treatments 2 days before the start of bed rest. At the start of the first day of bed rest a muscle biopsy was taken (DAY 1), and participants began treatments again for the next 4 days of bed rest. On the 5th day of bed rest (POST), a muscle biopsy was taken, and participants stopped their treatments the night before and did not continue on their treatments for the remainder of the study. After a 1‐week recovery period (REC) participants returned and underwent another muscle biopsy.