Introduction
­chemotherapy-induced nausea/vomiting, cancer, CINV
CANCER, CHEMOTHERAPY-INDUCED NAUSEA AND VOMITING, ADVERSE EFFECT
Chemotherapy-induced nausea and vomiting (CINV), a major adverse effect of cancer treatment, is associated with a significant deterioration in life quality.In the 1990s, it was demonstrated that the use of ­5-hydroxytryptamineOver the past decade, olanzapine, an antipsychotic medication that blocks multiple neurotransmitters in the central nervous system, has been demonstrated to be an effective agent for preventing CINV.The above-noted data demonstrate that there are 4 drug types that are effective for decreasing highly emetogenic ­chemotherapy-induced nausea/vomiting (corticosteroids, 5-HTGiven the above question, the current clinical trial was developed to compare 2 olanzapine-containing antiemetic regimens, one with the use of an NK-1 receptor antagonist and one without. When this trial was developed, olanzapine was an inexpensive generic agent while NK-1 receptor antagonists were quite expensive.