Intervention
Alzheimer’s disease, ’s eleven-module cognitive training battery.
BRAIN, NEUROLOGICAL DISORDERS
The CCT group received 24 1-h sessions (three sessions/week × 8 weeks) using the Chinese Food and Drug Administration (FDA)-approved Cognitive Assessment and Rehabilitation Training Machine (hereinafter, the Machine; Xiamen Amity Brain Health, China, No. YJRZ-LJ-01). The machine delivers clinical evaluation and training packages in electronic format for the rehabilitation of patients with neurological disorders. The CCT utilized the machine’s eleven-module cognitive training battery. We have reported positive treatment effects of the same 24-session CCT elsewhere [The clinical protocol for the CCT spanned 2 weeks of inpatient treatment followed by 6 weeks of outpatient visits to the rehabilitation departments of the participating hospitals. In each session, the participants sat in front of computer screens and completed the training modules assigned by the rehabilitation therapist. Descriptions and assignment logistics of the eleven training modules, such as attention, working memory, and response speed, can be found in Supplementary Table SParticipants in the control group received eight 1-h weekly sessions of health education through outpatient visits to the hospital rehabilitation departments. The contents covered in the sessions were collated based on the Alzheimer’s disease prevention guidelines published by Barnard et al. [