Author Contributions
W.-H.T. designed the in vitro and animal studies. C.-H.C. performed the in vitro and animal studies. J.-H.J. performed the WGS analysis. W.-H.T. and I.-J.W. analyzed the data. E.-K.L., W.-W.C., W.-H.T. and I.-J.W. wrote the article. All authors have read and agreed to the published version of the manuscript.