Author contributions
X.X. and L.X. designed the study. W.S., S.C. and W.W. collected all data. Y.Z. and L.Z. analysed and interpreted the data. Y.S. wrote the first draft of the paper. X.X. and A.S.H. revised the work. Y.S., Y.Z., and W.S. are co-first authors. All authors approved the final version of the manuscript. Y.S. and X.X. had full access to all data and takes responsibility for data integrity and the accuracy of the data analysis.