Supplementary information

Reporting SummaryTumor mutational burden.DEG_epithelial_On versus pretreatment in patients with PFS > 6 months and PFS < 6 months from scRNAseq analysis.Gene set enrichment analysis using Gprofiler.ISG and MAPK gene list used for the ISG and MAPK scores calculation.RNAseq gene signatures from BRAF/MEK/EGFRi trial.