Acknowledgements
®
The study was funded by the Wellcome Trust (223016/Z/21/Z). TJ is supported by a grant from UK Medical Research Council (MC_UU_00002/14). For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission. Tetris® has been licenced for use within i-spero® from The Tetris Company. The authors would like to thank the Intensive Care Society, in particular Dr Sandy Mather and Alex Day; Our Data Monitoring Committee members comprising Prof Andreas Reif (chair, Frankfurt am Main—Goethe University), Prof Steve Hollon (Vanderbilt University), Prof Ian Penton-Voak (Bristol University), and adjunct member Prof Michael B. Bonsall (University of Oxford); Trial Steering Committee including Prof Guy Goodwin, Pooyan Behbahani, and Rebecca Dias; Expert Advisors including Dr Nick Grey, Prof Sir Simon Wessely, and Prof Jonathon Bisson. Members of study team including Veronika Kubičková, Alfred Markham, Zunaid Islam and Marie Kanstrup for support; Our Data Management Team including Mark Dziedzic, Sameer Iqbal, and Nikita Shukan.