Secondary outcomes
AKI, hyperchloremia
METABOLIC ACIDOSIS, HYPERCHLOREMIA
First, we planned to evaluate the association between the use of the continuous infusion of hypertonic saline solution and the occurrence of hyperchloremia and metabolic acidosis. Second, we studied the association between the continuous infusion of HSS and the need for renal replacement therapy (RRT) within 28 days after starting the infusion of HSS. Third, we studied the association of AKI from inclusion to Day 28 with chloride level and cumulative chloride dose infused. Finally, we tested the association between AKI and ICU length of stay, the need of RRT from inclusion to Day 28, and ICU mortality. As an exploratory analysis, we also compared eGFR and the highest creatinine levels between the two groups.