Study design and patients
weakness, infections, CR-GNB
INFECTIONS, DISORDERS
This is an open, multicenter, randomized, controlled study conducted according to the principles of Helsinki Declaration and was approved by the ethics committees of the participating hospitals. Written informed consent was obtained from the patients before they were randomly assigned to various groups. When patients and had no capabilities due to consciousness disorders, sedative states, intense weakness, their families signed the informed consent, and the patient was required to sign a new informed consent if he/she regained capabilities during the trial.A total of 26 hospitals in Henan province of China and all patients admitted from January 2021–2022 participated in this study. The inclusion criteria were as follows: (1) age 18–75 years; (2) suffered from severe infections caused by CR-GNB susceptible to polymyxin B (minimal inhibitory concentration [MIC] ≤ 2 mg/L by microdilution broth method) [