Introduction
infection, coronavirus disease 2019, fever
VIRUS, CORONAVIRUS DISEASE 2019, SARS-COV-2 INFECTION, INFECTION, CAVITY
SARS-CoV-2, the cause of coronavirus disease 2019 (Covid-19), a Betacoronavirus, belongs to the coronaviride family. It is a single-stranded, positive-sense RNA virus [There is evidence that the oral cavity is a SARS-CoV-2 reservoir because ACE2 is highly expressed in the oral non-keratinizing squamous epithelium. Moreover, researchers successfully detected the SARS-CoV-2 RNA in the saliva [Prevention of SARS-CoV-2 infection is important in dental clinics; hence, it is critical to break the viral transmission chain between the patients and staff. There are some recommendations for this. The first step is to use personal protective equipment. Patient evaluation and identification of patients with potential Covid-19 infection are very crucial. The use of a non-contact thermometer is recommended for temperature measurement. A questionnaire can screen the patients; it should investigate whether the patient had any Covid-19 infection symptoms, such as fever and respiratory problems, during the past 14 days and if they had a close contact with a confirmed Covid-19 infected patient within the past two weeks [Despite the application of these health recommendations, because of the presence of asymptomatic patients in to dental clinics, additional protective measures should be considered before and during dental procedures, such as the use of disinfectants and mouthwashes.Today, a large number of antimicrobial mouthwashes are available on the market that have natural or synthetic antiseptic compounds. Preoperative antisepsis mouthwashes are frequently used in dental offices [Recent publications have recommended that using antiseptic mouthwashes may control the viral load of SARS-COV-2 in the saliva. However, scientific evidence is lacking/contradictory for the anti-SARS-COV-2 effects. Although researchers have investigated the in-vitro effects of antiseptic mouthwashes on Covid-19 [Methods.We systematically reviewed studies including patients with a SARS-CoV-2 positive test that used a mouthwash for SARS-COV-2 viral load reduction. In this study, we adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement 2020 recommendations provided by Liberati [