Follow-up, Outcomes, and Definitions
death
CVD, EVENTS, EVENT, MYOCARDIAL INFARCTION, STROKE
Time 0 was defined as date of first ART start, and individuals were followed until the first CVD event, loss to follow-up, death, or last cohort visit (database closure on 30 September 2022). Individuals in the INSTI group who stopped INSTIs during follow-up were censored at that time, and those who received an initial ART without INSTIs were censored when they switched to an INSTI-based therapy (artificial censoring). The outcome of interest was the time to the first CVD event, which included myocardial infarction, stroke, and invasive cardiovascular procedures. CVD events were collected using a dedicated case report form and validated from a senior HIV physician at the cohort site. In addition, central validation was performed using a standardized algorithm blinded to the ART history of the patient [