2.3. Randomization and Intervention Programs
weight loss
After a baseline evaluation, participants were randomized to receive dulaglutide combined with CRD or CRD alone, hinged on the predetermined number generated by a computer with a 1:1 allocation, which was concealed using opaque, sealed, and serially numbered envelopes. Participants remained on their prescribed treatment program until they reached the 7% weight loss goal (determined by initial body weight at randomization), which was reported to be associated with ameliorative metabolic outcomes [Dietary consultation was conducted by dietitians from the Department of Nutrition in the hospital. Once enrolled in the trial, participants received personalized dietary information booklets that provided portion advice and specific one-week recipes. CRD is a dietary pattern that maintains basic nutritional requirements while restricting energy intake, with a ratio of macronutrients meeting the requirements of a balanced diet. Dietitians calculated daily calorie requirements using the following formula: (height (cm) – 105) × 20 kcal, and all participants were instructed to follow a diet of 1000 to 1300 kcal per day. In the diet, carbohydrates accounted for 40–55% of the total calories, fat 20–30%, and protein 15–20% [