ACKNOWLEDGMENTS
This work was supported by the National Natural Science Foundation of China (No. 81974356, No.61771313, and No.82102665), the National Key R&D Program of China (2020YFC2004200), and the Shanghai Sailing Program (No.21YF1404600). The sponsor played no role in the study design, data collection, data analysis, data interpretation, or writing of the manuscript. The authors are indebted and thank all patients for participating in this study, Dr. Jerry for English revision, and Ms. Yefan Cao for assistance on figure drawing.