Introduction
obesity, non-alcoholic fatty liver disease, NAFLD, endocrine disorder, inflammation, PCOS, Adolescent polycystic ovary syndrome
OBESITY, ENDOCRINE DISORDER, INFLAMMATION, ANDROGEN EXCESS, NON-ALCOHOLIC FATTY LIVER DISEASE, INSULIN RESISTANCE
Adolescent polycystic ovary syndrome (PCOS) is a common endocrine disorder hallmarked by clinical and biochemical androgen excess and irregular menses. PCOS appears to be driven by ectopic lipid accumulation specially in the liver that essentially originates from a mismatch between (reduced) prenatal adipogenesis and (augmented) postnatal lipogenesis, resulting in central obesity, insulin resistance, non-alcoholic fatty liver disease (NAFLD), and low-grade inflammation (Follistatin was initially identified in and isolated from follicular fluid based on its inhibition of pituitary FSH secretion (