Randomization
FMNST
Participants were randomly allocated in a 1:1 ratio to receive either 850 mg Placebo or 850 mg Metformin as an adjunct to Full Mouth non-surgical therapy (FMNST) by using a computer-generated random sequence. Allocation to treatment was concealed in consecutively numbered opaque envelopes and revealed to the therapist and patients at the end of the last visit of the last patient of the trial.