Ethics approval and consent to participate
All methods were carried out in accordance with relevant guidelines and regulations of he World Medical Association Declaration of Helsinki ethical principles. All experimental protocols were approved by the Ethics Committee of Shenzhen Children’s Hospital of China Medical University (IRB no. 201904802). The consent was obtained from all subjects and/or their legal guardian(s). All participating children were verbally informed of the consent and relevant trial protocol in advance. The rights of the participants were protected, all participants and at least one of each patient’s parents or a legal guardian signed a statement of informed consent before the was enrolled.