Subgroup analysis based on MCI subtype
AD-specific deficits, aMCI, MCI, impaired delayed recall
We also tried to perform subgroup analysis based on the MCI subtype. There were significant differences in AVLT recall term in the aMCI subgroup between the two groups after the intervention. The changes in ReHo values in dl-SFG and ACC were positively correlated with improving overall cognitive function, and FC changes in vmPFC-LAG was negatively correlated with the STT-B score. The vmPFC is the core node of the former default mode subnetwork. Studies have found that FC in anterior DMN of patients with aMCI increases [In the naMCI group, we found significant differences in global cognitive function between the two groups after the intervention. The change of ReHo value in the rEAP group was associated with improving verbal and executive domains. In contrast, the improvement of delayed recall was negatively correlated with the change of FC in PCC. Previous studies have found that impaired delayed recall may be because of AD-specific deficits in learning and storage processes and inefficient encoding or retrieval strategies caused by poor execution in patients with naMCI, which may lead to decreased memory performance [Interestingly, we did not observe the association between the increase of ReHo value in the executive brain region and memory improvement in the rEAP group. However, we observed that the decreased FC value of PCC-RMTG was negatively correlated with AVLT long term score, similar to the results of previous studies [