Implications of study findings
Our findings imply that 60 g of Na Ascorbate given over 6 h significantly increases UO over time compared with placebo. Moreover, these observations suggest that such treatment can also lead to a greater decrease in vasopressor dose and SOFA score over time than placebo. Finally, they suggest that such mega-dose treatment can deliver ascorbate blood levels which are up to 30 times those seen in a previous trial of high dose therapy [