Statistical analysis
AKI
Continuous variables were expressed as mean (± SD) or median (IQR). Categorical variables were expressed as percentage. Missing data were identified, and multiple imputations (5 iterations) were used for variables with less than 20% missing data. Continuous variables normally distributed were compared with unpaired Student t-tests. A Wilcoxon test was used for other continuous variables. Categorical variables were compared with the Chi-Square test. In univariate analysis, we identified the unbalanced variables between the two groups (control vs. interventional arm) and any variables associated with AKI from inclusion to Day 28. For repeated measures comparison, we performed a mixed model with a “subject” random effect variable and a “time” fixed effect variable. Results of the mixed model are shown as coefficients and estimated 