Discussion
PTD, dysbiosis, vaginal dysbiosis
EARLY PREGNANCY
The potential benefit of vaginally applying Although current literature suggests that women with PTD have a reduced presence of lactobacilli as part of the vaginal microbiome, increased bacterial diversity, and low vaginal levels of beta-defensin-2Nevertheless, intermediate dysbiosis has a prevalence of approximately 7%The limitation of this study represents a smal avaliable size of this specific group of pregnant women, e.g. Absence of vaginal lactobacilli species. Overall, given that only 1% of women with intermediate vaginal microbiota have a complete absence of detectable In our study, we observed a decrease in the Nugent score among many participants. The greatest reduction was 4 points in subgroup C, the women who harbored no Pregnant women with a normal vaginal microbiota during the first trimester of pregnancy have a 75% lower risk of delivery before 35 weeks of gestation, and an abnormal vaginal microbiota in early pregnancy is a risk factor for PTD and low birthweightTo date, the effectiveness of antibiotic treatment of vaginal dysbiosis in pregnancy, as well as its influence on pregnancy outcomes, remains unclear