Inclusion criteria and sample collection.
infection
INFECTION
Peripheral blood (PB) samples were collected during a dose-finding controlled infection study using Colonization was assessed by culture of nasal wash samples on PB was collected in EDTA blood collection tubes on D0, D1, D3, D4, D7, D9, D11, D14, D28, and D56 after challenge. PB was taken early in the morning and transported to Leiden University Medical Center (LUMC), the Netherlands, where flow cytometric evaluation was performed within 12 hours after donation. In 2 participants (ID.08 and ID.13), the expression of CD45RA on lymphocytes was found to be unusual, most likely caused by a CD45RA-related polymorphism (