3.4. Ischemic Index
The UWFA images of the eyes were assessed before (V1, baseline) and 2, 4, and 8 weeks after (V7, V8, and V9, respectively) drug administration. There was an overall significant decrease in ischemic indexes during the investigation period (Greenhouse–Geisser F = 9.456, To observe changes in ischemic indexes within each group, the repeated measures ANOVA test was used. The ischemic index significantly decreased over time (Greenhouse–Geisser F = 9.456 for the main effect of time), and a significant interaction effect was observed (Greenhouse–Geisser F = 10.946 for time × group interaction). A significant change in the ischemic index was found in the >1.59 group (Wilk’s lambda F = 9.142, In the >1.59 group, the ischemic index was significantly different compared with the baseline value at V7, V8, and V9 (