Conclusions
hyperandrogenism, PCOS
PREGNANCY-INDUCED HYPERTENSION, PRE-ECLAMPSIA, HYPERANDROGENISM, PREGNANCY COMPLICATIONS
S-PROK1, in the second trimester, did not predict pregnancy-induced hypertension, pre-eclampsia, or late miscarriage/preterm delivery in pregnant women with PCOS. s-PROK1 was lower in women who used metformin at conception. Women who used metformin at conception and during pregnancy compared with those who used metformin from inclusion or not at all and those with hyperandrogenism compared with normo-androgenism exhibited lower s-PROK1. Further studies are needed to determine the exact role of s-PROK1 in pregnancy complications and the involvement of metformin and hyperandrogenism in the regulation of PROK1 in PCOS.