Model analysis
The incremental cost-effectiveness ratio (ICER) and the net monetary benefit (NMB) was used to assess the cost-utility analysis at the WTP threshold value of USD $ 10.000. According to Paulden et al. [Deterministic sensitivity analysis (DSA) using a tornado diagram was performed to investigate the variation of the ICER/ NMB when parameters are varied independently. The parameters of the model were varied by ± 20 to assess the effect that each variation on the ICER and NMB.Probabilistic sensitivity analysis (PSA) was performed to investigate the uncertainty of ICER and the possibility of PRP effectiveness. In this regard, a Monte Carlo Simulation approach with 10,000 hypothetical samples was used., Gamma Distribution and Uniform Distribution models were used for cost and utility parameters, respectively.This analysis was performed using the TreeAge Pro Software (2020).