Statistical analysis
REGRESSION
Characteristics of placebo and donepezil-treated groups were described as means and standard deviations for continuous variables, and as counts and percentages for categorical variables. Differences in characteristics between placebo and donepezil-treated groups were evaluated using one-way ANOVA or Kruskal–Wallis for continuous variables, and the chi-square test for categorical variables.We used multiple linear regression testing for interactions (backwards, with the best general lineal model—Complementary, we also studied differences in the effect of donepezil treatment across MRI subtypes defined using the conventional categorical approach. Mixed ANOVAs were performed to assess the interaction between the categorical subtypes (between-subject factor, four levels: All statistical analyses were performed using R 4.0.2, and results were deemed significant when 