Background
malaria
MALARIA
Insecticide-treated nets (ITNs) are the main malaria control and prevention intervention with over two and a half billion nets distributed globally between 2004 and 2021 [In response to the threat of pyrethroid-resistance, dual active ingredient (AI) ITNs treated with a mixture of a pyrethroid and a non-pyrethroid insecticide or compound to which local vector populations are largely susceptible have been developed for malaria vector control. Three new ITN types, pyrethroid-piperonyl butoxide (PBO), pyrethroid-chlorfenapyr and pyrethroid-pyriproxyfen ITNs, were recently added to the World Health Organization (WHO) list of prequalified vector control products after demonstrating improved impact against pyrethroid-resistant malaria vectors compared to pyrethroid-only nets [Following the WHO recommendation, an increased uptake of pyrethroid-chlorfenapyr and pyrethroid-pyriproxyfen nets is expected in the coming years. However, to be considered long-lasting, new ITNs need to be evaluated for their physical and insecticidal durability over 3 years of operational use [Experimental hut trials are typically used for assessing the entomological efficacy and wash resistance of ITNs under semi-field conditions for the WHO prequalification and for determining the non-inferiority of new ITN products to a similar product that has demonstrated empirical evidence of improved epidemiological impact in cRCT [This paper describes the methodology for a prospective longitudinal study investigating the attrition, physical and insecticidal durability of two dual AI ITNs (Interceptor® G2 and Royal Guard