Exploratory responder analyses
Based on the trajectories of their alcohol use, three patients were classified as responders (i.e. reduction of mean alcohol use by two or more WHO risk drinking levels) and 8 as non-responders. The mean reduction in daily alcohol use from baseline to the last study visit (month 18) was 43.4 g/d (±226.7) in non-responders and 198.1 g/d (±52.7) in responders. At baseline, responders showed a significantly higher craving for alcohol (