Results
pain
This study was conducted as a double-blinded clinical trial. Somehow, 44 patients who met the inclusion criteria of the study were selected from those who were referred to the dental clinic of Mazandaran University of Medical Sciences (18 men and 26 women) and completed the treatment and study period. At the same time, they were divided into two groups: intervention (Atorvastatin) and control (Placebo) groups. 22 patients were included in each study group and all patients were studied and examined for 7 days. To evaluate the diameter of the inflammatory halo, patients were clinically examined on the baseline (day zero), 3rd, 5th, and 7th days. The patients were also taught to determine the intensity of pain based on the VAS scale. Participants in this study reported no side effects or complaints from the mucoadhesive tablets (Fig. 
CONSORT flowchartThe comparison of gender in the two groups showed that the distribution of gender in control (female: 59.1%, male: 40.9%), and atorvastatin (female: 59.1%, male: 40.9%) groups were not significantly different from each other and they were homogeneously distributed (P = 0.999). Also, the mean and standard deviation of the age in control (14.27 ± 39.09) and atorvastatin (13.64 ± 34.81) groups were examined, and according to the results of the Mann-Whitney test, the mean age in the two groups did not show a statistically significant difference (P = 0.372).