4. Discussion
premature senescence
DNA DAMAGE, PATHOLOGY, ASH, SKIN CONDITION
Caviar, internationally acclaimed as a highly esteemed seafood, is prized for its abundance of protein and fat, establishing it as an exceptional source of high-quality protein in food [Previous studies have demonstrated that the protein, carbohydrate, and ASH content of caviar increased more in supercritical COIn the clinical trial, a caviar group was formulated to assess the effects of caviar extract alone, while a combination group was included as an example of a finished product, containing well-known ingredients recognized for their positive impact on skin elasticity, hydration, and wrinkle improvement, such as fish collagen, hyaluronic acid, and ascorbic acid [Type 1 collagen induces collagen synthesis in human dermal fibroblasts, while MMPs degrade collagen [UVB radiation induces ROS, causing DNA damage, premature senescence, and melanin production within melanocytes, along with tyrosinase (TYR) [Clinical pathology tests, including hematological, biochemical, and urine tests, were conducted to ensure the safety of CV. To ensure safety, clinical pathology tests such as blood tests, biochemical tests, and urine tests were conducted. Safety evaluations revealed that almost all values exhibited no significant differences within or between groups. Some clinical hematological test results or biochemical test items showed significant differences between groups; however, these variations were within the clinical laboratory reference values, making it challenging to assign clinical significance. Based on the confirmed data, CV can be considered an effective food ingredient for improving skin conditions.