Treatment effects on psychological variables (mean scores)
Cancer, Anxiety, anxiety, cognitive impairment, Insomnia, depression, Depression, Fatigue
RECURRENCE, CANCER
Linear mixed models with repeated measures revealed significant time effects on HADS‐D, HADS‐A, FCRI, ISI, FSI‐number of days, and FACT‐Cog‐impact scores (see Table Least Squares Means (standard errors) of Scores Obtained on Each Symptom at Each Time Assessment and Results of Mixed Models Analyses of Variance (ANOVAs).Abbreviations: Extent, how much of the day they felt fatigued; FACT‐Cog, Functional Assessment of Cancer Therapy—Cognitive Function; FCRI, Fear of Cancer Recurrence Inventory; FSI, Fatigue Symptom Inventory; HADS‐A, anxiety subscale of the Hospital Anxiety and Depression Scale; HADS‐D, depression subscale of the Hospital Anxiety and Depression Scale; Impact, impact on quality of life; ISI, Insomnia Severity Index; Others, comments from others; PCA, perceived cognitive abilities; PCI, perceived cognitive impairment; PHQ‐9, Patient Health Questionnaire‐9; V0, baseline; V2, 3 months; V3, 6 months; V4, 9 months; V5, 12 months.
The FACT‐Cog‐Impact subscale was the only variable on which a significant group‐by‐time interaction was obtained, but post hoc analyses indicated a significant change in the placebo group only with a greater score at V3 (