Potential mechanisms underlying GRE
seizures, epilepsy, neuronal hyperexcitability, immune dysfunction, Epilepsy seizure, glioma
GLIOMA, EPILEPSY
GRE and glioma are comorbidities and share common pathogenic mechanisms. In this study, we explored the mechanisms underlying GRE and discovered that ion channel and immune system dysfunctions may play a major role in the epileptogenesis of GRE.Epilepsy is correlated with changes in neuronal excitation/inhibition balance. Ion channel malfunctions can influence the extracellular concentrations of ions and neurotransmitters, inducing neuronal hyperexcitability that lead to seizures [The correlation between immune dysfunction and glioma is widely accepted. Moreover, the relationship between immune dysfunction and epilepsy has been studied intensively, and the 2017 International League Against Epilepsy seizure classification identified immune group as a major etiological category for epilepsy [