Introduction
glaucoma, hypotrichosis, Eyebrows
HAIR LOSS, HYPOTRICHOSIS, GLAUCOMA
Eyebrows are an important feature of facial identity and communications in human beings as well as an important eye defense shield from dust and foreign bodies [The eyebrow hair cycle is comprised no differently from other hairs of three phases (anagen, catagen and telogen) however with specific characteristics. Almost 10–15% of eyebrow follicles are in anagen phases which last from 15 to 30 days in average while the majority of follicles (85–90%) are in telogen phase which last for 60–90 days [Minoxidil has been approved for treating male and female pattern hair loss and was found to stimulate hair growth by limiting and regressing the telogen phase of hair follicles as well as by prolongation of the anagen phase resulting in increased hair follicle size. A few number of reports and studies proved an eyebrow enhancement and favorable safety effect of topical minoxidil use in eyebrow hyptrichosis [Bimatoprost is a prostamide, a sytnthetic prostaglandin used to treat glaucoma. The mechanism of bimatoprost and prostamides for enhancing hair growth is still unclear. It is well-known that prostaglandin receptors exist in dermal hair papillae and outer root sheath of the hair follicles. It is predicted that bimatoprost may stimulate the transition of hair follicles from the telogen to the anagen phase and prolong the duration of the anagen phase as well as stimulate melanogensis increasing hair length and darkness [Bimatoprost in its 0.03 and 0.01 formulations was studied in a number of recent studies and compared to one another which revealed its safety and efficacy as a therapeutic potential for eyebrow hypotrichosis [To our knowledge, there has been no previous report of randomized trials comparing, the efficacy and safety between 0.01%, 0.03% bimatoprost and minoxidil 2% in gel formulations for eyebrow enhancement has been published to date which is the main aim of the presented study.