Results
thrombosis, pulmonary embolism, pain, infection, venous thrombosis
THROMBOSIS, PULMONARY EMBOLISM, POSTOPERATIVE COMPLICATIONS, INFECTION, VENOUS THROMBOSIS
A total of 208 patients underwent THA during the study period, and 47 patients were excluded according to the inclusion and exclusion criteria, including 42 patients who met the exclusion criteria, and 5 patients who were excluded for other reasons. The 161 patients were randomly assigned, 79 to the topical TXA group and 82 to the intravenous TXA group (Fig. Flow diagram showing participant screening and allocationThere was no statistically significant difference in demographic data such as sex, age, height, weight, BMI, and cardiac ASA grade between the two groups (The comparison of demographic data of two groupsThe hip pain score on the first day after surgery in the topical TXA group was significantly lower than that in the intravenous TXA group (3.54 ± 0.46 vs. 3.84 ± 0.39, The comparation of VAS socre and inflammatory indicators level (CRP, IL-6, ESR) between two groupsThe comparation of tramadol consumption between two groupsThe CRP, IL-6 and ESR level on the first day after surgery in the topical TXA group were significantly lower than that in the intravenous group (The scatter diagram of the CRP, ESR, IL-6 with VAS score 1 day after surgery, correlation analysis was used to analyze the associationsThe postoperative evaluation showed no significant difference in the decrease of Hb values between the two groups (12.22 ± 4.05 g/L vs. 17.07 ± 4.04 g/L, In the topical group, 1 patient developed intramuscular venous thrombosis after surgery, and was given hypodermic anticoagulant therapy with 4000 IU Q12h low-molecular weight heparin after a specialist consultation. One week later, re-examination showed that the thrombosis had disappeared. There were no postoperative complications such as pulmonary embolism or incision infection in the 2 groups (