Introduction
deterioration of pancreatic beta-cell function, T2DM
TYPE 2 DIABETES
The natural history of type 2 diabetes (T2DM) is characterized by the progressive deterioration of pancreatic beta-cell function over timeHere we show that one such strategy is the administration of initial short-term IIT (as induction therapy) followed by metformin (as maintenance therapy), an approach that has been shown to stabilize beta-cell function for 2-years in some patients but not others