INTRODUCTION
Nonadherence, HYpertension
Nonadherence to antihypertensive drugs (AHDs) is one of the most important barriers to achieve blood pressure control [Only a few randomized clinical trials have been performed that investigate interventions improving adherence in patients with resistant hypertension [In this unique randomized, controlled trial RHYME-RCT (Resistant HYpertension: MEasure to ReaCh Targets), we compared an intervention with DBS sampling at the moment of blood pressure measurement combined with feedback using our communication tool on top of standard of care (SoC) compared with SoC alone. The primary aim of our trial was to determine whether this intervention leads to a decrease in resistant hypertension. Our second aim was to determine whether this decrease in resistant hypertension was due to an improvement in adherence.