Toxemia
toxemia
TOXEMIA
Rabbits became toxemic as early as 20 h post-challenge (first blood collection after exposure), and all rabbits were toxemic prior to treatment. Median time to positive toxemia was 24.1 h, and 24.3 h for the IGIV and ANTHRASIL-treated groups, respectively. The average time from challenge to toxemia was 26 h for the treated animals and the average time to treatment was 32.4 h post-challenge. The lag time between the onset of toxemia and treatment was due to the time needed to run the ECL assay.The proportion of toxemic animals (those with ECL results > limit of detection (LOD) (1.0 ng/mL)) after treatment in the IGIV group was significantly greater than that in the ANTHRASIL group (p < 0.05, two-sided Fisher’s Exact test) (