4. Discussion
delirium, hypotensive, hypotension
EVENTS, HYPOTENSIVE
Intraoperative hypotensive events are risk factors for postoperative mortality in older patients.The recovery profile was similar in patients in both groups. The context sensitive half time of remimazolam is longer than that of propofol.There was a previous study by Sekiguchi et alRemimazolam could be adopted as a reasonable alternative hypnotic agent to propofol, especially in patients vulnerable to decreased blood pressure. Some anesthesiologists may be reluctant to use remimazolam because of the risk of perioperative delirium associated with benzodiazepines. However, none of our patients administered remimazolam developed delirium. Similarly, the drug was not reported to be associated with delirium in patients undergoing cardiovascular surgery or transcatheter aortic valve implantation.A lower dose of remimazolam is required for LOC in older patients and adjusting the remimazolam dose can further lower the risk of hypotension.The study limitations include the type of surgery and possibly the single ethnicity of the participants. However, the race is expected to have a small to negligible effect on pharmacological profile of remimazolam.