Statistical analysis
In the phase III trial conducted in Japan, the mean (standard deviation [SD]) time from the end of general anesthesia to first eye opening was 10.3 (5.1) min in the propofol group [Normality of the distribution of continuous variables was determined using the Shapiro–Wilk test. Continuous data are reported as the mean (SD) or median (interquartile range [IQR]) and were compared between the two groups using the independent t-test or Mann–Whitney U test, respectively. Categorical data are presented as frequencies or percentages and were compared between the two groups using the chi-square test or Fisher’s exact test according to their expected counts. The effect sizes and their 95% CIs were also calculated. The Bonferroni correction was applied for multiple comparisons of variables related to the recovery speed of consciousness other than the primary outcome.Statistical analyses were performed using R software, version 3.6.1 (R Foundation for Statistical Computing, Vienna, Austria). All statistical tests of hypotheses were two-sided, and 