Study design
open-angle glaucoma
OCULAR HYPERTENSION, OPEN-ANGLE GLAUCOMA
The present multicenter, randomized, open-label, investigator-masked, parallel-group clinical trial investigated the efficacy and safety of preservative-free and preserved brimonidine in patients with open-angle glaucoma or ocular hypertension. The involved institutions were CHA Bundang Medical Center, Pusan National University Yangsan Hospital, Ulsan University Hospital, and Nowon Eulji Medical Center. This study was approved by the institutional review boards of CHA Bundang Medical Center, Pusan National University Yangsan Hospital, Ulsan University Hospital, and Nowon Eulji Medical Center and adhered to the tenets of the Declaration of Helsinki. This study conformed to CONSORT 2010 guidelines (The participants were enrolled in four institutions from June 2019 to January 2021. The participants were fully informed and voluntarily provided written consent before screening and were randomized into two groups after providing agreement; namely, the unit-dose preservative-free brimonidine (Bridin-T