4. Discussion
cancers, prostatitis, tumor, Tumor, inflammation, prostate, prostate cancer
SYSTEMIC INFLAMMATORY RESPONSE, CANCERS, METASTASIS, PROSTATITIS, TUMOR, TUMOR, INFLAMMATION, PROSTATE, GENETIC DISORDERS, URINARY SYSTEM DISEASE, BACTERIAL PROSTATITIS, BLOOD, PROSTATE CANCER
In this study, we confirmed the correlation between AISI and the occurrence of csPCa. Based on AISI and 5 other clinical parameters, we constructed a nomogram to predict the probability of csPCa occurrence. The validation of the nomogram showed its good discriminatory and calibration ability.Tumor formation, metastasis, and host antitumor immunity are all significantly influenced by inflammation [Blood cell counts are widely utilized and available in clinical practice as the most common tool to reflect systemic inflammatory response. Systemic inflammatory markers such as NLR, PLR, SII, and AISI generated from the inflammatory cell counts are independent predictors of various cancers. In our study, these four blood-related composite markers were selected and further screened to construct a nomogram by AISI. AISI was computed based on the number of platelets, neutrophils, lymphocytes, and monocytes, which can represent most blood cell types. We found that AISI may be a potential marker to predict the risk of csPCa development. Furthermore, we hope that AISI can be used in combination with other biomarkers as a valuable indicator to assess the risk of prostate cancer and provide some help to improve the accuracy of biopsy in patients.Apart from the acknowledged systemic inflammation, one of the most significant pathological changes is the localized inflammation, which also plays an important part in the development of prostate cancer. Bacterial prostatitis, as a common urinary system disease, accounts for approximately 5-10% of the overall prostatitis cases [Age and prostate volume are fundamental clinical parameters in most prostate cancer studies. Cormio et al. [In addition, ethnic factor is also an important risk factor for the development of prostate cancer. In a genome-wide study of Chinese prostate cancer patients, 2 SNPs (9q31.2 and 19q13.4) were found to be strongly associated with prostate cancer prevalence in the Chinese population, which is significantly various from the genetic susceptibility to prostate cancer in European and American populations [There are several drawbacks in this study. First, this is a retrospective analysis. Thus, some selective biases may be unavoidable. Second, AISI is a nonspecific tumor marker, and further prospective randomized controlled trials are needed to validate our findings. Finally, blood cell parameters may be influenced by factors such as diet and genetic disorders, and we cannot completely exclude these factors.