Acknowledgements
We acknowledge and thank the patients and their families for their participation in this study. We also express gratitude Dr. Shirui Zheng from Innovent Biologics (Suzhou) Co., Ltd for medical assisting. This study was sponsored by The National Natural Science Foundation of China (No. 82002835), The National Key Research and Development Project (No. 2022YFC2705005) and Guangzhou Science and Technology project (No. 202201011572).