Introduction
OLT, biliary atresia
SECONDARY
Conventional orthotopic liver transplantation (OLT) is complicated and involves a high risk of acid-base imbalance and drastic haemodynamic fluctuations [Although several improvements in crystalloids have been made in the past decade, more effective crystalloids for OLT are lacking. Recent evidence suggests that acetate-buffered solutions result in better hemodynamic stabilization than 0.9% saline in patients undergoing major surgery and also reduce lactate levels compared with LR in infants with biliary atresia [However, due to poor liver function and the anhepatic phase in LT patients, the liver has poor metabolic capacity for acetic acid. Lv [To overcome these problems, a new type of crystalloid solution, bicarbonate Ringer’s (BR) solution has recently been used for fluid resuscitation. Compared to AR solution, BR solution is characterized as a direct liver and kidney metabolism-independent HCOHowever, whether BR solution is more effective in acid-base equilibrium and more conducive to better liver function than AR solution remains unclear. To date, and to our knowledge, there has been a paucity of evidence in the literature on the comparative influence of AR or BR solutions. Therefore, our primary objective in this randomized controlled trial was to compare the effects of AR or BR solutions infused during surgery and used to prepare the 2% albumin solution for graft washing on pH and base excess (BE) levels in OLT patients. The secondary outcome measures were intraoperative 5% sodium bicarbonate infusion incidence and volume, as well as laboratory indicators related to liver and kidney function.