Participants
diabetes, Knee osteoarthritis knee pain, pain, KOA
SYSTEMIC ILLNESS, HYPERTENSION, DIABETES
Knee osteoarthritis knee pain patients and HCs were involved in this study. The diagnostic criteria for KOA were derived from the American College of Rheumatology (ACR) criteria and published in their adjusted form in 1991.The matched HCs were enrolled. The inclusion criteria were that all HCs: (1) were aged from 40–60 years and were right‐handed, (2) were free from any pain conditions, (3) had no history of mental or CNS illness, (4) had no history of any systemic illness, like diabetes or hypertension, and (5) provided written permissions to conduct the study. HCs met the exclusion criteria if they: (1) were women who were either pregnant or nursing, (2) were alcohol or drug abusers, or (3) had contraindications to MRI scan.