Plasma PK parameters
nausea and vomiting, upper right panels].Both, vomiting, SAD
All of the 36 subjects receiving IV administration of contezolid acefosamil were included in the plasma PK analysis. The mean plasma concentration-time curves of the major metabolites (MRX-1352, contezolid, and MRX-1320) after IV SAD of contezolid acefosamil are shown in Mean plasma concentration-time curves of MRX-1352, contezolid, and MRX-1320 after intravenous administration of single ascending dose (500, 1,000, 1,500, and 2,000 mg) of contezolid acefosamil in healthy Chinese subjects (semi-logarithmic scale in the left lower panels and zoom-in view of linear scale in the upper right panels).Plasma pharmacokinetic parameters of contezolid in healthy Chinese subjects after intravenous and oral administration of contezolid acefosamilSubject 2A206 was excluded from this PK analysis due to nausea and vomiting.These steady-state data were the mean values of nine subjects because the data of one subject were invalid due to nausea and vomiting on days 9 and 11.Data are presented as median (minimum, maximum) for AUC, area under the concentration-time curve; AUCAfter intravenous infusion of a single ascending dose (500–2,000 mg) of contezolid acefosamil, the median After IV SAD of contezolid acefosamil, the One subject in the 1,500-mg cohort of oral SAD study was not included in the PK analysis set due to vomiting. The vomiting might have some effect on the reliability of the concentration data. One subject in the 1,500-mg multiple-dose cohort was also excluded from PK analysis set due to vomiting on D9 and D11. The mean plasma concentration-time curves of MRX-1352, contezolid, and MRX-1320 after oral SAD of contezolid acefosamil are shown in Mean plasma concentration-time curves of MRX-1352, contezolid, and MRX-1320 after oral administration of single ascending dose (500 and 1,500 mg) of contezolid acefosamil in healthy Chinese subjects [semi-logarithmic scale in the left lower panels and zoom-in view of linear scale (0–12 h) in the upper right panels].Both the 