Introduction
lupus disease, SLE disease, lupus, connective tissue disorder
DISEASE, LUPUS, CONNECTIVE TISSUE DISORDER, SYSTEMIC LUPUS ERYTHEMATOSUS (SLE), COMPLICATIONS
Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory connective tissue disorder that affects multiple organs [The 5-year survival rate of SLE patients has increased to 90% in most treatment centers due to early diagnosis and improvement of therapeutic factors to control the disease and relevant complications [As an adjuvant, NAC therapy is a controversial issue among rheumatologists in managing and controlling lupus disease. Therefore, considering the high prevalence of lupus in Iran, the importance of using anti-oxidant agents in controlling lupus activity, and existing contradictory on NAC therapeutic effects in patients with lupus, the present study aimed to explore the effect of NAC on decreasing SLE disease activity and its complications and outcomes.