5. Conclusions
hypoxic damage, tissue damage, heat loss
VASODILATION, COLD, COLD
Cold exposure is directly related to the peripheral skin blood flow behavior, wherein vasoconstriction reduces the cutaneous blood flow to protect the skin against heat loss, tissue damage by the cold, and thus maintains a stable body temperature. It is further followed by vasodilation, which will prevent hypoxic damage. Thus, blood flow is a balance between multiple factors that cause vasodilation and vasoconstriction. To conclude, we have studied a localized cold-stimulated response and spontaneous rewarming to detect the cold sensation among healthy humans after HEPT7G/βCD inclusion complex consumption. The present findings demonstrate that the skin temperature and skin blood flow responses during localized cooling and spontaneous rewarming were also transferable to whole-body conditioning and ameliorated the cold sensation responses. This provides grounds for believing that hesperetin aglycone derived from deconjugation of hesperetin glucuronide metabolites after acute ingestion of rather small doses of highly bioactive HEPT7G/βCD inclusion complex (150 mg and 300 mg SunActive