2.11. Randomization, Allocation, and Blinding
blindness
BLINDNESS
In Trial 1, the enrolled participants were randomly assigned to the three test groups using the dynamic minimization method and in a 1:1:1 ratio. Age, sex, composite memory score obtained via Cognitrax and composition of ARA and DHA in plasma phospholipids were used as allocation factors to maintain a balance between groups. In Trial 2, allocations were performed in the same manner at a 1:1 ratio to achieve a balance between the groups regarding age, sex, verbal, and visual memory scores obtained via Cognitrax, the composition of ARA and DHA in plasma total lipids, and residential area. A third-party allocation agency managed the allocation information and ensured that double blindness was maintained until the data were fixed in both trials.