Introduction
EVENT, BLIND
The application of the most reliable evidence to address individual clinical issues underpins the core principle of evidence-based medicine [However, due to the particularity of certain interventions, it becomes challenging to blind participants and investigators in some clinical trials. Recent investigations have highlighted that traditional Chinese medicine (TCM) clinical trials encounter significant obstacles in placebo production, rendering some medications unsuitable for double-blind controlled trials [In this study, we use an open randomized controlled trial of TCM as an example to compare the outcomes of unblinded and blinded evaluations. Furthermore, we propose several strategies for implementing blinded evaluations in clinical trials, which encompass aspects such as staff allocation, training, participant management, trial drug administration, efficacy indicator collection, and safety event management.