2.13. Statistical Analyses
The primary outcome parameter was the difference in IHL between the two diets. Exploratory outcome parameters included the effect of the two diets on DNL, 24-h glycemic response, hepatic glycogen content, plasma BHB levels, hepatic lipid composition, plasma metabolites related to energy expenditure, energy expenditure, and substrate oxidation.The sample size of Results were expressed as mean ± SEM. Participant characteristics were expressed as mean ± SD. Continuous variables were tested for normality (Shapiro–Wilk test). In case variables were not normally distributed, non-parametric statistical tests were used. Changes in liver fat content/composition and glycogen between diets were assessed by a paired-sample Changes across the time course during the meal test after both diets and changes across the time course during the continuous glucose measurements on day 14 were assessed using a two-way repeated-measures ANOVA to evaluate any significant effect of diet and timepoint and any interaction between diet and timepoint. A 