Treatment
After confirmation of eligibility, patients were randomly assigned (by interactive response technology) in a 3:2 ratio to treatment with Isa-Kd or Kd (control arm). Patients were stratified by the number of prior treatment lines (1 vs >1) and Revised International Staging System stage (I or II vs III vs not classified).Patients in the Isa-Kd arm received Isa 10 mg/kg intravenously (IV) on days 1, 8, 15, and 22 of the first 28-day cycle, and on days 1 and 15 of subsequent cycles. In both study arms, carfilzomib was administered IV at 20 mg/m