4.8. Statistical Analysis
SECONDARY
The change in the maximal incremental plasma glucose level (iCmax) between baseline and endpoint within intervention groups vs. control was predefined as the primary outcome measure of the study. Changes in insulin levels and the incremental area under the curve (iAUC) were secondary outcome measures. The area under curve (AUC) for glucose and insulin was calculated using the trapezoidal rule, and the net AUC was calculated by subtracting the AUC below baseline values. The normality of the obtained data was analyzed by the Shapiro–Wilk test. To analyze the glucose and insulin levels over time, a repeated measures ANOVA was conducted. Subjects were considered fixed effects, while treatment and time were treated as repeated measures. To account for multiple comparisons, a Bonferroni adjustment was applied. The correlation was evaluated using Pearson or Spearman correlation, as appropriate. Differences were considered significant at 