Secondary outcome measures
REGRESSION, SECONDARY, ADVERSE EVENT
Growth and bone-related secondary outcomes will be considered non-inferiority outcomes and so will be analysed as per the primary outcome using both ITT and per-protocol analyses. Biochemistry and adverse event outcomes will be considered superiority outcomes and so will be analysed using ITT analyses only. Continuous outcomes will be analysed using linear regression models, adjusting for minimisation variables and baseline response (where applicable). Adjusted mean differences will be presented alongside 95% confidence intervals. Binary outcomes will be analysed using log binomial regression models, adjusting for minimisation variables, with both a log and identity link to obtain risk ratios and risk differences, respectively. 