3.3. Secondary Outcomes and Exploratory Outcomes
fungemia, infections
MICROBIAL COLONIZATION, FUNGEMIA, SECONDARY, INFECTIONS
The secondary outcomes are displayed in There were no statistically significant differences in the mean CRP concentration, mean ferritin concentration, mean lactate dehydrogenase (LDH) concentration, and mean D-dimer concentration over time between the patients in the anakinra and placebo care groups at enrollment (Day 0), at Day 2, or at Day 10 post enrollment (data not shown). Confirmed microbial infections occurred in four (27%) patients in the anakinra group (of which one was fungemia caused by candida species, and the remaining infections were considered colonized organisms) and two (13%) patients in the usual care group, which were both microbial colonizations (Regarding the observed cytokine levels, only the levels of IL-6, IL-10, IL-18, and CXCL9 were noted to be significantly elevated (i.e., detectable and above the reference range for normal in over 50% of the subjects) at the time of enrollment (see 