Mendelian randomization data and process
PD, cardio-cerebrovascular diseases
To investigate the causal link between PD and cardio-cerebrovascular diseases, we used a two-sample MR research. Figure Flow chart of Mendelian stochastic analysis, The study satisfies the three main assumptions of Mendelian randomization: Assumption 1: The solid line indicates that the instrumental variants directly affects the incidence of PD. Assumption 2: Dashed lines indicate that instrumental variables are not related to any potential confounders. Assumption 3: The instrumental variables affect the outcome only through the exposure, and not through any other causal pathways.