Author contributions
RECRUITMENT
LS was the trial coordinator, analyzed and interpreted the data, and wrote the first draft of the manuscript. AS, JD and RO were members of the steering committee, and contributed to study design. ZT contributed to the study design and patient recruitment. NH advised on pharmacy related matters. HP was involved as a member of the steering committee and local principal investigator, contributing to patient acquisition. AB, JS, KS, MB, JL and DB were local principal investigators in participating ICUs involved in patient acquisition. WR was involved as a trial statistician, and advised on study design, data analysis and interpretation. MJ was the principal investigator, responsible for funding, study design and execution, patient recruitment, and drafting the manuscript. All authors revised, read and approved the final manuscript.