Implications of all the available evidence
inflammation, PWH
CVD, INFLAMMATION
Our findings suggest that the lipid mediator of inflammation profile, some with important functions in CVD risk, is distinct by HIV status. Importantly, our data also suggest aspirin does not increase the production of aspirin triggered specialized pro-resolving mediators (AT-SPM) in PWH. These results are in line with other findings that inhibition of platelet activation in response to aspirin is also blunted in PWH. Given the potent platelet directed activities of AT-SPM, we believe that our present observations provide insights into mechanism behind the failure of aspirin to regulate platelet responses in these patients. Taken together, these results suggest that aspirin might potentially be less effective in PWH. The clinical implication of these results for CVD prevention in PWH needs to further addressed in future studies.