Conclusion
These findings suggest that the zero PEEP group was more likely to induce a higher number of patient–ventilator asynchronies in difficult‐to‐wean patients.Low‐level pressure support ventilation (PSV) is most commonly adopted in spontaneous breathing trials (SBTs). This study aims to investigate the effects of two PSV protocols on the patients' respiratory mechanics. These findings suggest that the enhanced low‐level PSV protocol was more likely to induce a higher number of patient–ventilator asynchronies in difficult‐to‐wean patients.

Baozhu Zhang, Zhe Zhang and Haiping Qin contributed equally to this work.