Baseline assessment
inflammation, psychiatric, infections, psychosis
INFLAMMATION, INFECTIONS, TUBERCULOSIS (TB)
All participants (60 inflamed psychosis, 30 non-inflamed psychosis and 30 HCs) will attend a baseline assessment comprising psychiatric measures, cognitive tasks, blood sampling and neuroimaging (optional). This will be the final study contact for patients without evidence of inflammation and HCs. Patients with evidence of inflammation will undergo further tests to establish safety/eligibility to receive tocilizumab, including an X-ray of the chest and blood tests to exclude pregnancy and certain infections, such as tuberculosis (TB), human immunodeficiency viruses (HIV), and COVID-19. Eligible participants will be randomised and invited for infusion.