Methods
Breast Cancer
MAY, BREAST CANCER
The prospective open-label, pragmatic three-armed study was designed as a comprehensive cohort study and was conducted in three centers, the Research Institute Havelhöhe and Department of Internal Medicine, Hospital Havelhöhe, Berlin, Center of Integrative Medicine University Witten/Herdecke and Breast Cancer Center, Hospital Herdecke, Herdecke, Department of Rehabilitation Medicine, Hannover Medical School, Hannover, all located in Germany. The trial was conducted from June 2011 to December 2013. Patients were first invited to participate in the study and to be randomized into one of the three treatment arms; if they declined random assignment they could choose their preferred treatment arm. Here, we present a 4-year follow-up undertaken from May 2016 to February 2017. This CRF-2 study is an investigator-initiated trial which was conducted according to the declaration of Helsinki