Acknowledgments
The authors thank Dr. Yuxuan Chen and Tian Sun for their help in sample collection. They also thank all patients, their families, and physicians who involved in the study. This work was supported by the National Key R&D Program of China (2020YFA0710800), the National Natural Science Foundation of China (31700779), the Key Program of National Natural Science Foundation of China (81930043), and the Major International (Regional) Joint Research Project of China (81720108020).