Methods for additional analyses (e.g., subgroup analyses) {20b}
DISEASE
We will perform adjusted and stratified analyses including mixed-effect models to examine other plausible differences, for example, differences in average causal treatment effect between men and women, and adjusting for site. We plan to explore differences in stratified analyses based on the patient type of disease, disease severity at baseline, type of pharmacological treatment at baseline, and physical activity level measured by accelerometry at baseline.