Limitations
A few limitations of this study merit attention. Despite a washout period of at least two weeks, we cannot fully exclude carry-over effects due to potential long-term effects of psychedelics [Moreover, LSD is known to affect heart rate, blood pressure and body temperature [Due to the salient subjective effects of LSD, blinding is inherently difficult. Thus, knowledge about the condition could have impacted neural effects and future studies should include active control conditions. Although do note that one of the studies included an active control [Finally, while classification performances in this study were promising, they should be taken as preliminary until replicated in an external sample.