References
sleepiness, PVT, PVT reaction
TSD
Study design. Experimental design including a habituation and training day (D0), a baseline day (D1), and a total sleep deprivation (TSD) day beginning on D1 at 23:00 until D2 at 21:00. Subjects completed the psychomotor vigilance task (PVT) every 6 h and were EEG-recorded during the PVT at 09:15 at D1 and D2. They also completed the Karolinska sleepiness scale (KSS). (↓) 08:30 and 14:30; acute placebo or caffeine (2.5 mg/kg) intake.PVT reaction times during total sleep deprivation as a function of caffeine daily consumption. Graphical representation of the linear mixed-model analysis showing a trend of an interaction between habitual daily caffeine consumption and time awake (from 2 to 32 h) in the conditions of acute placebo (PVT reaction times during total sleep deprivation for the three caffeine consumption groups. Polynomial curve fitting of mean reaction times (RT, mean ± S.E.M) as a function of time spent awake (h) for low (blue), moderate (green), and high (red) habitual caffeine consumption groups in the placebo (EEG power spectra before (D1 day) and after (D2 day) total sleep deprivation (TSD) for placebo (PBO) and caffeine (CAF) conditions at different regions of interest (ROIs). Power spectra (µVRelationships between subjective sleepiness (KSS) scores, PVT reaction times, and individual alpha frequencies as function of the habitual caffeine consumption in response to total sleep deprivation (TSD). (Effects of habitual caffeine consumption, awakening, and treatment on PVT performances. A linear mixed-model analysis was performed on PVT reaction times (RT). Significant Effects of treatment condition (PBO vs. CAF), day (D1 vs. D2), and caffeine consumption groups (low, moderate, and high) on EEG parameters. A linear mixed-model analysis was performed for the EEG theta, alpha, and beta power at each region of interest (ROI), assessing fixed effects of treatment, day, and caffeine group as well as their respective interactions. Significant 