Outcome
bipolar 1 disorder, cognitive impairment, bipolar disorder, mania, psychiatric
MEDICATION SIDE EFFECTS
The primary aim of this study was to investigate the effect of spironolactone as adjunctive therapy compared to placebo on reducing the severity of mania symptoms in patients with bipolar 1 disorder. Patients referred to the outpatient clinic of Imam Ali Hospital with the diagnosis of bipolar disorder type 1 in a mania episode were evaluated to enter the study. These patients were subjected to additional examinations in terms of clinical, psychiatric, and pharmacological conditions if they met the inclusion criteria and did not meet the exclusion criteria (along with obtaining informed consent from the patient/patient's guardian).They were examined in terms of the severity of mania symptoms using YMRS, the severity of cognitive impairment using MMSE, and quality of sleep using PSQI at the beginning of the study and then in weeks 4 and 8. Also, the appetite status of the patients was evaluated using SNAQ, and the condition of body mass was examined using BMI at the beginning and end of the study. They were also regularly evaluated using the side‐effect checklist in terms of medication side effects related to the clinical trial.