Author contributions
L.Z. and K.Q. conceived the research ideas. L.Z. and L.T. performed the experiments. K.Q. analyzed the data and wrote the main manuscript text. Y.L. and T.L. provided the related references and funding. W.B. ran a thorough check on the use of English for scientific writing. All authors contributed to manuscript revision, and each read and approved the revision and final manuscript. All study subjects provided informed consent.