Subject characteristics
sepsis, congenital anomalies, liver disease
SEPSIS, NECROTIZING ENTEROCOLITIS, LIVER DISEASE
A total of 91 infants born ≤ 28 weeks were screened for eligibility. 62 were ineligible for the following reasons: multiple gestations (n = 27), feeding problems or necrotizing enterocolitis (n = 14), lack of consent form in parent’s language (n = 4), respiratory support below eligibility criteria (n = 4), congenital anomalies (n = 4), sepsis or instability (n = 3), possible liver disease (n = 3), staff unavailable to perform study (n = 2), attending request (n = 1). A total of 6 premature infants were enrolled in this study. The original enrollment target was 18 infants. Slow enrollment and budgetary limitations, which precluded updating the Certificate of Analysis on the L-citrulline product used in this study, necessitated the termination of the study after the sixth study patient was enrolled. The median birth weight was 1050 grams (range 769–1430 g) and the weight at the time of study was 1487.5 grams (range 1330–1880 g) (Table Patient Characteristics.Values presented are counts (%) for categorical variables or median (min,max) for continuous variables.