White Blood Cell mobilization
The WBC count was increased by approximately 2- to 4-fold from baseline levels after injection for all MRG-001-treated subjects, reached the peak levels between 8 and 12 h, and returned to baseline levels or near baseline levels at 48 h (WBC mobilization with MRG-001 in healthy subjectsSubjects received SC injections every other day of saline (placebo control, n = 6), low-dose (0.005 mL/kg), mid-dose (0.01 mL/kg), or high-dose (0.02 mL/kg) MRG-001 (n = 4/group). Venous blood was collected to determine the WBC differential count at several time intervals.(A) WBCs on day 1 after a single dose SC injection of saline or MRG-001.(B) WBCs on day 5 after the third dose SC injection of saline or MRG-001. Each value represents the mean ± SD. The gray area represents the normal reference range.