Introduction
neurodegeneration, neuroinflammation, cognitive impairment, dysfunction of the blood-brain, Cognitive impairment, cognitive behavioral deficits
DISEASE, NEURODEGENERATION, DISEASE COURSE
Cognitive impairment refers to impairment of one or more cognitive areas, including memory, executive ability, language, attention, and visual space (Cognitive impairment is a complex multifactorial disease involving chronic neuroinflammation, dysfunction of the blood-brain barrier (BBB), and neurodegeneration (Thus far, a number of studies have reported that probiotics and prebiotics reversed the cognitive behavioral deficits of AD mice and increased the diversity of gut microbiota and neurogenesis (However, there are still few studies on cognitive impairment treatment with FMT, such as the choice of transplantation method, disease type, and disease course, which do not allow to recommend FMT for clinical application. More research is needed to answer these questions. Therefore, we conducted this study to understand the safety and efficacy of FMT in cognitive impairment treatment and provide a basis for further large sample studies of FMT in cognitive impairment treatment.