Background
dysplasia, Osteoarthritis, OA, arthritis
OSTEOARTHRITIS OF THE KNEE, OSTEOARTHRITIS, DISEASE, DYSPLASIA, ARTHRITIS, ADHESION, ARTHROPATHIES
Osteoarthritis (OA) is a very frequent disease especially in elderly people. Caused by overweight, improper load of the joint, injuries, dysplasia, arthritis or other arthropathies, a progressive destruction of the joint cartilage may potentially involve the bone, the joint capsule and the adjacent muscles [The analgesic effect of radiotherapy on patients with OA has been known for a long time. There is a large body of retrospective publications showing a good analgesic effect of radiotherapy for osteoarthritis of the knee joint in 58–91% of patients [There have been research activities on arthritis models in order to clarify the mechanism of the effect of radiotherapy in OA treatment, which have led to an improved understanding. Radiation has been shown to inhibit the adhesion of macrophages to the endothelium, induces the expression of the x‑linked apoptosis inhibitor, of the transforming growth factor beta (TGFβ), reduces the expression of E‑ and L‑selectin and inhibits the expression of interleukin 1 (IL‑1) and the chemokine ligand 20 (CCL 20). All these effects are maximal after single doses of 0.3–0.7 Gy [We thus conducted a prospective randomized trial in order to examine the effect of radiotherapy on painful OA and to provide a high level of evidence. We now report the final data after 12 months of follow-up.