Randomization and interventions
APPENDIX
Randomization was performed via a centralized web-app designed by MORU software engineers using RShiny, hosted on a MORU webserver. For all sites, envelopes were generated initially as backup. The no study drug arm comprised a minimum proportion of 20% and uniform randomization ratios were then applied across the treatment arms. For example, for five intervention arms plus the no study drug arm, 20% of patients would be randomized to no study drug and 16% to each of the five interventions. Additional details on the randomization are provided in Appendix 3. All patients received standard symptomatic treatment.Ivermectin (600 μg/kg; 6 mg tablets; Atlantic Laboratories, Thailand) was given once daily for 7 days with food (see 