BOINcomb design
The two-dimensional BOIN design for drug combination trials is based on an extension of the one-dimensional design. The details are as follows. Assume that The rules of BOINcomb are as follows:Treat the first cohort of subjects with the lowest dose combination (1, 1).Assuming that the current cohort is treated with dose combination (If If Otherwise, if This process continues until the total sample size is exhausted.During dose escalation and de-escalation, if there are multiple optimal dose combinations in sets 