Co-primary outcomes
death

Duration of IV antibiotics (h), derived from the starting and stopping times of IV antibiotic useComposite safety outcome with three components:Unscheduled admissions/readmissions to the paediatric intensive care unit (PICU) with/without infective diagnosis, or unplanned readmission to hospital, within 7 days of stopping IV antibioticsRestarting IV antibiotic therapy (for any reason) within 7 days of stopping IV antibioticsMortality (death for any reason) in the 28 days following randomisation