Author contributions
RA
CD, PL and PLS designed and supervised the clinical, laboratory and genetics studies. CG and QB coordinated the field clinical epidemiological study in children. MNM, AN, RA, AB processed the samples. KK, SW and IL performed host genetic analyses. LQ managed the database and clinical and epidemiological statistical analyses. AA and YS analysed and interpreted the host genetics data, and AA was the major contributor in writing the manuscript. GZ contributed to data analysis and proofreading the manuscript. All authors read and approved the final manuscript.