Quality of life
bloating, fatigue, cognitive functioning, social functioning, pain, insomnia, dyspnoea, pancreatic pain
APPETITE LOSS, PANCREATIC DUCTAL ADENOCARCINOMA
The development of quality of life over time in both groups is shown in Functional domains and global health status from QLQ-C30 compared between patients who underwent open and laparoscopic distal pancreatectomy
Symptom domains from QLQ-C30 compared between patients who underwent open and laparoscopic distal pancreatectomy
Symptom domains from PAN26 compared between patients who underwent open and laparoscopic distal pancreatectomy
Symptom and functional domains from PAN26 compared between patients who underwent open and laparoscopic distal pancreatectomy
When comparing only the values from 2 years after surgery, a clinically relevant difference of 10 or more between the groups was seen for the domains of emotional functioning, cognitive functioning, social functioning, fatigue, pain, dyspnoea, insomnia, appetite loss, pancreatic pain, bloating, indigestion, weakness of arms and legs, troubled with side-effects, future worries, (limitation regarding) planning of activities, and sexuality, with better results in the minimally invasive group. The domains of social functioning, insomnia, and pancreatic pain were significantly worse in the open group according to Values at the 24-month follow-up compared between the two treatment arms are shown as the mean with 95 per cent confidence intervalsThe In the sensitivity analyses with mixed models among the patients without pancreatic ductal adenocarcinoma, the results were unchanged except that the domains of pancreatic pain, bloating, and satisfaction with healthcare were no longer significant. In the analyses with mixed models among the patients with Clavien–Dindo scores of II or less, the results were unchanged except that the domains of insomnia and future worries were no longer significant, and financial difficulties were significantly higher in the open group.When comparing the groups solely among patients who had undergone splenectomy, only emotional functioning and indigestion remained significantly better in the laparoscopic group. For this reason, separate mixed models analyses were conducted between patients who had undergone splenectomy and patients who had not. Only the domains of dyspnoea and troubled with side-effects significantly differed between the groups, with better results among patients who had undergone spleen-preserving procedures.
