Introduction
cutaneous allodynia, aura symptoms, Cutaneous allodynia, headache, migraine, Migraine, hypersensitivity, nausea, vomiting
BRAIN DISORDER, COLD, SENSITISATION PROCESS, MIGRAINE, MIGRAINE, HYPERSENSITIVITY
Migraine is a common, multifactorial brain disorder, characterized by recurrent headache attacks with nausea, vomiting and hypersensitivity to movement, light and sound, and sometimes with aura symptoms. Most patients have the episodic form, with a median attack frequency of 1–2 per month [Migraine chronification is hypothesised to be a decreased threshold problem, in which patients have increased susceptibility for migraine attacks. This increased susceptibility may be a consequence of central sensitisation, a state of ongoing excitability and hyper-responsiveness of central regions of the brain [Thus, cutaneous allodynia, and especially the spatial distribution of cutaneous allodynia, may be used as a clinical marker of the presumably sequential central sensitisation processes. Cutaneous allodynia can be perceived upon thermal or mechanical stimuli. Hence, it is experienced during daily activities, such as combing hear, exposure to cold, wearing tight clothes, and resting the head on a pillow [