2.2. Association of Concentrations with CYP Genotype and Phenotype of Subjects
In total, 39% of the participants had a normal metabolism (NM) (genotype *1/*1), 56% had an intermediate metabolism (IM) (genotype *1/*2 or *1*3), and 5% had a poor metabolism (PM) (genotype *2/*2, *2/*3 or *3/*3), according to the CYP2C9*2*3 enzyme phenotype.The CYP2C19*2*17 enzyme phenotype revealed that 39% of subjects had a normal metabolism (NM) (genotype *1/*1), 24% had an intermediate metabolism (IM) (genotype *1/*2 or *2/*17), 32% had a rapid metabolism (RM) (genotype *1/*17), 3% had an ultra-rapid metabolism (UR) (*17/*17), and 2% had a poor metabolism (PM) (genotype *2/*2).Subjects were divided into categories for the CYP3A4 enzyme based on genotype. Consequently, 92% of them were wild type and 8% were heterozygous. No statistical significance was seen in the concentration differences at any timepoint when the CYP2C9 and CYP2C19 phenotypes were considered.A statistically significant difference in the concentration of CBD in urine for timepoint 3 was seen for the CYP2C9 enzyme in male participants. Men with the NM phenotype had higher CBD values than males with the IM phenotype (At timepoint 2, the CBD/7-COOH-CBD concentration ratio had a statistically significant result for CYP3A4 (