Pharmacokinetics of ultrafiltered cisplatin
Plasma ultrafiltered and total cisplatin PK data were available from eleven patients. Intraperitoneal fluid samples were available from six patients at the end of cisplatin administration. A total of 147 samples (6 IP, 71 UF and 70 PB cisplatin concentrations) were used to estimate pharmacokinetics parameters. The final structural pharmacokinetic model included four compartment: three compartments with available concentrations (VThe PopPK plasma ultrafiltered cisplatin concentration vs. time curve including individual observations is shown in Fig. PK POP plasma ultrafiltered cisplatin concentration vs. time curve including individual observations (∙) and 5th, 50th, 95th percentiles of plasma ultrafiltered cisplatin individual prediction