Study Design
This study was developed in healthy subjects in the fasting or postprandial state, using a single-dose, randomized, open-label, two-period, two-sequence, self-crossover design. It authorized by the Ethics Committee of the First Affiliated Hospital of Bengbu Medical College. The ethical approval process complies with the requirements of Good Clinical Practice (GCP), the Declaration of Helsinki and relevant Chinese laws and regulations. Registration number CTR20200764 at 26-Apr-2020. According to "the Guiding Principles for Human Bioavailability and Bioequivalence test of Pharmaceutical Preparations (2015 Edition)", "the Guiding Principles for Human Bioequivalence Research of Chemical Drug Imitations with Pharmacokinetic Parameters as the End Point Evaluation Indicators", and recommended dose in Tamiflu® instructions, the single oral dose of 75 mg/12.5 mL was determined for the reference preparation and test preparation of this study. According to the data in the relevant literature [