Randomization and masking
Participants were randomized in a 1:1 ratio to an 8-week period of fully closed-loop glucose control with faster-acting insulin aspart (Fiasp) followed by an 8-week period of standard insulin therapy, or vice versa. Randomization was performed using a web-based, permuted blocks-of-four randomization method to assign study participants to one of the two treatment sequences. Participants and investigators were not masked to the intervention used during each period because of the nature of the interventions.