Ethics approval and consent to participate
The trial was approved by Institutional Research Ethics Committee (No.2020–178) of the 1st Affiliated Hospital of Wenzhou Medical University on July 15th 2020 and registered in Chinese Clinical Trial Registry (ChiCTR2000037974). This study was conducted in adherence to the principles of the Helsinki Declaration and complied with CONSORT standards. Informed consent in this study was acquired from patients before participation.