Conclusions
From a long-term cost-effectiveness modelling of data from a pragmatic RCT ciclosporin produced positive incremental net health benefit relative to infliximab. Our results indicated that ciclosporin is dominant compared with infliximab for the treatment of the NHS ASUC patients, however, these results are subject to some degree of uncertainty, mostly due to non-significant difference in health outcomes between competing drugs. In the long-term, ciclosporin was cost-saving relative to infliximab even though it (ciclosporin) was associated with an estimated higher colectomy rate, and remained cost-effective against an NHS WTP threshold value of up to £20,000.