Safety
Somnolence, tachycardia, somnolence
ADVERSE EFFECTS, SIDE EFFECT
Only two DME patients reported adverse effects. One patient in the placebo group informed tachycardia 2 weeks after treatment and abandoned the study, whereas one levosulpiride case reported somnolence, which could relate to the study medication as it is a known side effect of levosulpiride. Somnolence occurred 6 weeks after initiating treatment and the patient withdrew from the study. There were no significant differences in mean ocular pressure, mean serum levels of HbA1c, mean glomerular filtration rate, and mean blood pressure between the placebo- and levosulpiride-treated DME patients (Table 