Primary outcomes
fracture, purulent, infection, fistula, fracture-related infection
INFECTION
The primary outcome of this study will be the occurrence of fracture-related infection (FRI), a binary outcome. FRI is a consensus definition of infection after fracture treatment that is clinically diagnosed by an orthopedic surgeon based on any of the following four diagnostic criteria: (1) fistula, sinus, or wound breakdown; (2) purulent drainage from the wound or presence of pus during surgery; (3) phenotypically indistinguishable pathogens identified by culture from at least two separate deep tissue/implant specimens; or (4) presence of microorganisms in deep tissue taken during an operative intervention, as seen on histopathological examination. It is expected that the peak diagnosis time will occur between 6 weeks and 6 months; however, these criteria will be assessed by an orthopedic surgeon at every follow-up time point.