Oxidative stress induction sensitizes AML PDX to imetelstat
OXIDATIVE STRESS
The finding that responses to imetelstat are associated with baseline molecular signatures annotated as oxidative stress and that the mechanism of action of imetelstat features ROS-mediated ferroptosis led to the hypothesis that oxidative stress induction can sensitize to imetelstat therapy.Standard induction chemotherapy composed of cytarabine and an anthracycline is a potent inducer of ROS