Sequence generation {16a}
Computer-based random sequences will be generated by the statistician in charge of the analyses. A total of 240 random extractions from a Bernoulli distribution with a probability equal to 0.5 will be performed to assign patients 1:1 to the interface rotation (treatment) or standard of care (control) group. Moreover, following the same procedure, patients in the interface rotation group will be assigned to start their treatment wearing an oronasal mask or full face/hybrid masks. The randomization list will be uploaded into the research electronic data capture (REDCap) system that will provide the assigned arm of the patients. Investigators will have no access to the randomization list.