INTRODUCTION
Clinician-Administered, Treatment-emergent adverse, psychosis, psychotic symptoms, psychotic disorders
ADVERSE EVENT
Dissociation is a clinical construct that incorporates a variety of different types of symptoms, ranging from disturbances in perception of sensory, proprioceptive, or temporal information to disturbances in one’s sense of self or identity. The extent to which the nature of these dissociative experiences is consistent across different clinical conditions or diagnoses has received relatively little attention. For instance, a recent meta-analysis of clinical and nonclinical samples examining the relationship between dissociation and psychotic symptoms in patients with psychotic disorders found a “robust” relationship between dissociative experiences and multiple positive psychotic symptoms but less consistent relationships with negative symptoms (The patterns of dissociation-related symptoms that occur in association with i.v. ketamine treatment as quantified by the Clinician-Administered Dissociative States Scale (CADSS) have been described by multiple groups (It has also been reported that the correspondence between a clinician’s perception of dissociation occurring as an adverse event vs dissociation as characterized by structured measurements (e.g., the CADSS) may vary (Treatment-emergent adverse events, including dissociation and psychosis, were monitored and recorded in the pivotal registration trials of esketamine, thereby providing the opportunity to evaluate the relationship between these (i.e., between patient experience and clinician-reported assessment) as well as adverse event reports of dissociation or psychosis. We thus conducted post hoc analyses of data from the SUSTAIN-2 study (