Conclusions
obesity, T2D, weight loss
OBESITY, REMISSION
Patients with obesity and T2D submitted to metabolic surgery by mRYGB improve their metabolic phenotype in parallel with significant modifications in the microbiome composition. Incretin response is restored after weight loss and is associated with a specific microbiota signature after one year of follow-up. These changes operate in parallel with T2D remission. Further studies are guaranteed to confirm a causal role of the microbiome changes on incretin response and T2D remission in patients with obesity.