Introduction
seizures, seizure, epilepsy, neurotoxic, epileptic
ADVERSE EFFECTS, EPILEPTIC, EPILEPSY
Up to 65 million people worldwide are affected by epilepsy.The three main objectives of epilepsy treatment are total seizure control, maintaining quality of life (QoL), and avoiding adverse effects (AEs).KD (a high-fat, adequate-protein, and low-carbohydrate diet) is an effective, non-invasive, and non-pharmacologic treatment for refractory childhood epilepsy used since 1920s with few to no neurotoxic effects when compared to multiple ASM.Despite the KD’s effectiveness, most patients discontinue the diet because of its unpalatable and restrictive features. So, new variants of KD have emerged, including the modified Atkins diet (MAD) and the low-glycemic-index diet.MAD provides a more palatable and less restrictive dietary treatment option.However, since KD is not a physiological diet, it is important to identify and carefully monitor any AEs.Electroencephalographic (EEG) features are improved by KD in addition to significantly reducing clinical seizures in epileptic patients. Despite this, there have not been any reported prospective studies of the predictive power of baseline EEG or early changes in EEG for KD therapy response. In addition, few research have compared the electrophysiologic properties of KD responders and non-responders.So, this study aimed to assess short- and long-term efficacy, safety, and tolerability of KD (classic KD and MAD) in childhood DRE and to investigate the effect of KD on EEG features of children with DRE.