Authors’ contributions
MFA led the model-based economic evaluation in the project, made the first draft and critically reviewed the manuscript. MFA also developed the cost-effectiveness model, analysed model data and interpreted results. He was assigned by the trial chief investigator, JGW, to have full access to the study database, and took final responsibility to prepare and finalize the manuscript for publication. DC was one of the principal investigators of the study and the overall lead for health economics. ML and SG contributed the analysis and interpretation of economic data. LA, HH, AW and JGW were involved in study design. All authors have contributed to the interpretation of data, commented to the draft of the manuscript and approved the final version. MFA is the corresponding author and the guarantor of the manuscript.