1. Introduction
adolescence, upper incisors, overjet
DISORDER, REGRESSION
Increased dental overjet in adolescence is a clinically relevant outcome associated with the complexity and high cost of treatment, indicating the need for prevention strategies. We investigated the long-term impact of breastfeeding and pacifier use on increased overjet (IOVJ) in permanent dentition. A prospective cohort nested in a randomized controlled trial was conducted from birth to 12 years of age (Increased overjet, a developmental disorder in the craniofacial structures characterized by an exaggerated overlap of the upper incisors [The significant impact of increased overjet on clinically relevant outcomes associated with the complexity and high cost of treatment [From an analytical perspective, conventional regression analysis tends to fail to account for such a complex scenario in which breastfeeding protects against pacifier use, and its interruption may lead to pacifier initiation [Accordingly, the present birth cohort study aimed to investigate the long-term impact of breastfeeding and pacifier use during early childhood on increased overjet in adolescence. We hypothesized that breastfeeding protects from the risk of increased overjet in permanent dentition.