Potential targets for FOLFOX4-ATRA therapy
We performed a differential expression analysis to identify proteins that were affected by the FOLFOX4-ATRA treatment. We compared the protein expression between pre- and post-treatment within each response evaluation and treatment arm and identified 184 proteins that were significantly differentially expressed after the FOLFOX4-ATRA treatment (Further, we analyzed the interaction effects of treatment group and time point within each response evaluation and identified 13 proteins that were uniquely differentially expressed in the FOLFOX4-ATRA group compared to the FOLFOX4 alone group (adjusted Proteins that differed significantly between the pre and post FOLFOX4-ATRA treatment (adjusted 