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TRD, treatment-resistant depression, anhedonia, psychomotor retardation, debilitating symptoms, depression
Patients with treatment-resistant depression (TRD) experience a wide variety of debilitating symptoms, including persistent negative mood, anhedonia, psychomotor retardation and suicidal thoughts. While many patients with TRD who receive experimental subcallosal cingulate (SCC) deep brain stimulation (DBS) have responded to continuous stimulation with durable symptom reliefWe address this gap by leveraging several simultaneous advances to derive a data-driven brain-based biomarker of stable depression recovery that can be used to differentiate clinically acute scenarios from periods of normal transient distress (illustrated in Fig. 