Author contributions
CM, PMF, UC
GPS, PI, A. Giaccari designed the trial; MAG, LL, ML, and A. Giordano described and reviewed the nuclear procedures. DD performed, and F. Crea reviewed the cardiological procedures. F. Cinti, TM, CM, SG and UC performed the metabolic procedures. LL and ML performed the nuclear procedures. PMF reviewed statistical analysis. LL, F. Cinti and GPS gave the major contribution in analyzing data and writing the manuscript. All authors have read and approved the final manuscript.