Statistical analysis
tumour
TUMOUR
Details of sample size calculations were described previously.An Independent Review Committee (IRC) provided a review of the patient’s images, including CT, MRI, PET/CT and bone scan. Differences in the OS, PFS and the cumulative proportion of patients surviving at 3 and 5 years were compared using the Kaplan–Meier method. The response rate between the subsequent treatments was assessed using the Chi-square test. The effect of neoadjuvant treatment on OS in predefined subgroups (age, gender, N2 status and Based on the investigator’s evaluation of the tumour response from patients’ medical records, Post hoc analyses for subsequent treatments were conducted for patients who experienced relapse or progression after surgery. All analyses were performed using SPSS 25.0 (IBM, Armonk, NY, USA) and R statistical packages (3.4.3). All tests were two-sided and 