Data Processing
As these were ROM data, it was decided to select the assignments completed on the closest date to the time points of interest (baseline, 2 weeks, 4 weeks, 6 weeks, 8 weeks, 10 weeks, and 12 weeks). The following criteria were used to do this: (1) an interval of –6 days to +6 days from each of the time points of interest was considered, and if there were more assignments done in that period, the one on the closest date to the time point of interest was selected; (2) if in the –6 days to +6 days interval there were 2 assignments equally close to the time point (eg, 1 assignment done 4 days before the time point and 1 assignment done 4 days after the time point), the second one was selected (ie, the one after the time point); and (3) if no assignments were completed in that time interval, a check was done to see if any assignments were done on the seventh day before or after the time point. If neither of these conditions was met, no assignment was selected for that time point.As ROM data were used for outcomes with the criteria explained earlier, there were a number of missing PHQ-9 and GAD-7 assessments at each time point (for more details regarding missing data, see Table S1 in LCGA uses the maximum likelihood algorithm to handle both participants with full and missing data [