Missing data strategy
SECONDARY
For the primary end point, the area under the curve (AUC) of percent change from baseline in TLA by Briefly, for patients whose week 56 scans were delayed or missed due to the pandemic, the first available scan after the week 28 scan was used to impute the week 56 data in the primary analyses. In the absence of a PET–CT scan, data from the first available CT-only scans after the week 28 scan were used to analyze the primary end point and other secondary imaging end points as applicable. For missing week 56 scans solely due to the COVID-19 pandemic in patients who crossed over to garetosmab from placebo, the assumption of ‘missing completely at random mechanism’ was reasonable.