Molecular landscape
follicular adenoma, neoplasm, follicular neoplasm
FOLLICULAR ADENOMA, NEOPLASM, FOLLICULAR NEOPLASM
Considering the genetic alterations observed during all MD (Observed Pathogenic Molecular Alterations and Their Concurrent DiagnosisGH type CNA in high- and intermediate-risk groups are defined as suspicious GH type CNA with 6–23 of 23 affected chromosomes, possible but often no heterogenicity, or GH type CNA with any number of chromosomes affected with (possible) endoreduplication.Low-risk GH type CNA concern limited, unsuspicious GH type CNA with 1–5 of 23 affected chromosomes, possible heterogenicity, and no signs of endoreduplication.Patient declined the advised diagnostic surgery.CNA, copy number alterations; GH type, genome haploidization type; RCI type, reciprocal chromosomal imbalance type.Concordance was 63% (82/130) between MD and [Patient and Lesion Characteristics of Cases with Discordant Molecular Diagnostics and [Case numbers correspond to case numbers in This 15-mm neoplasm was difficult to diagnose, with a differential diagnosis of PTC or FA. After review by multiple expert thyroid pathologists and MD, it was finally considered a PTC, spindle cell variant, pT1b.This was a 32-mm follicular neoplasm with an 8-mm solid component and large cystic component, with a differential diagnosis of follicular adenoma or FVPTC. Morphologically difficult to diagnose, it was considered a pT2N0 M0 FVPTC only after an CNA, copy number alterations; F, female; FA, follicular adenoma; M, male; RCI type, reciprocal chromosomal imbalance; US, ultrasound.There were more MD-positive nodules among the [