Validation of prediction models
The C-index of the OS prediction model was 0.685 (95% CI, 0.664–0.705) in the development set and 0.716 (95% CI, 0.686–0.745) in the validation set. Meanwhile, the C-index of the CSS prediction model was 0.688 (95% CI, 0.666–0.710) in the development set and 0.713 (95% CI, 0.682–0.743) in the validation set. The calibration curve plots of two prognosis prediction models revealed an excellent agreement between the predicted and actual risks (Calibration curves of 1-, 3-, and 5-year OS in the development Calibration curves of 1-, 3-, and 5-year CSS in the development Time-dependent ROC curves comparing the prognostic accuracy of the OS prediction model with clinical risk factors in the development Time-dependent ROC curves comparing the prognostic accuracy of the CSS prediction model with clinical risk factors in development Decision curves of the OS prediction model in the development (upper) and validation (lower) sets.Decision curves of the CSS prediction model in the development (upper) and validation (lower) sets.