Statistical analysis
Both Intention‐To‐Treat and Per‐Protocol analyses were considered. Continuous data were expressed as means and standard deviation, with categorical variables expressed as number and percentage. Analysis of variance, Chi‐square, Fisher's exact, and Kruskal‐Wallis tests were used to compare baseline factors among groups. Bonferroni, Chi‐square, and Fisher's exact tests were used for pairwise comparisons. A paired t test and Wilcoxon's sign rank test were used for comparison of the same group before and after treatment. Kruskal‐Wallis, Fisher's exact, and Chi‐square tests were used to compare end points among each group. Collected data were analyzed using SPSS version 24 (SPSS Inc.). Statistical significance was defined as a two‐tailed 