Study Design
This nonblinded, randomized trial was performed in 11 Dutch hospitals: 1 academic hospital, 8 nonacademic teaching hospitals, and 2 nonacademic nonteaching hospitals. The study was approved by the Medical Research Ethics Committee Nijmegen, all 11 institutional review boards, and underwent an extramarginal review by the Central Committee on Research Involving Human Subjects. Trial registration was performed prospectively (NCT03228108). The study was monitored by an independent expert. The study protocol including amendments summary is available in 