2.3. Sample size
KOA
The mean values of the patients with KOA were obtained from previous studies. Subsequently, the sample size was obtained according to the expected effect of cryotherapy and HBE on the function of patients with KOA. In this regard, we expected that the mean value of 6.85 (standard deviation [SD]: 1.57) be reached 1.57 (SD: 1.67) considering the large sample size (Cohen d 1.39). The required sample size for each group was 15 patients. The actual power was 0.9562 (two tails, α error prob of 0.05, and allocation ratio N2/N1 of 1). G*Power 3.1.9 was used to calculate the sample size.