Limitations and Prospects
HYPOXIC, EVENTS
The sample size in the study was small. A larger study with no different baseline MS parameters should be conducted to obtain more reliable results. This was a single-centered trial using a limited number of patients, which does not allow firm conclusions in regard to rare but important safety events and side effects of IHHE.Secondly, the patient’s dietary regime as well as physical activity were not closely monitored, which may have partly influenced both the dynamics of TMAO and the effectiveness of hypoxic conditioning.Thirdly, TMAO values above the reference were found at baseline in only a small proportion of patients, which may have influenced the results of the study.Finally, the study was limited to a survey before–post 3-week interventions; longer monitoring might have revealed the timing of the persistence of the observed effects of IHHE.