Ethics approval and consent to participate
This study was approved by the Ethics Committees
of the Qingdao Municipal Hospital(group) (XCJJ No. 014 (fast) in 2020), and
registered in the center of Chinese Clinical Trial Registry (registration
number: ChiCTR2000039939,
date of registration:14/11/2020.). All methods were carried out in full accordance with
the Declaration of Helsinki. Informed consent was obtained from all subjects
and/or their legal guardian(s).