Background and rationale {6a}
diarrhea, hyperhydration, STEC, kidney injury, AKI, HUS, acute kidney injury
BLOODY DIARRHEA, COMPLICATIONS, COMPLICATION
Globally, there are over 2.8 million [Most STEC-infected children present for care when bloody diarrhea prompts medical attention; 15–20% of children infected with high-risk STEC develop HUS, and this complication ensues a median of ~ 7.5 days following the onset of diarrhea [Over four decades of research on STEC have produced elegant cellular and pathogen genomic insights but have not generated any interventions to reduce or avoid major complications including acute kidney injury (AKI). Narcotics [Observational studies have shown that early high-volume intravenous fluid administration (hyperhydration) is associated with reduced severity of kidney injury and may be effective in mitigating or preventing complications [