INTRODUCTION
cancers, breast cancer, cancer, Breast cancer, deaths
CANCERS, BREAST CANCER, INFLAMMATION, CANCER, BREAST CANCER, NODE-POSITIVE BREAST CANCER
A practice-changing, randomized, controlled clinical study established that preoperative hydroxyprogesterone administration improves disease-free and overall survival in patients with node-positive breast cancer. This research perspective summarizes evidences from our studies that preoperative hydroxyprogesterone administration may improve disease-free and overall survival in patients with node-positive breast cancer by modulating cellular stress response and negative regulation of inflammation. Non-coding RNAs, particularly Breast cancer is one of the most common cancer types worldwide, accounting for approximately 25% of all female cancers. According to the World Health Organization, an estimated 685,000 women succumbed to breast cancer in 2020, making it the fifth leading cause of cancer-related deaths overall [