INTRODUCTION
death, endotoxemia, injuries
HEAT, ENDOTOXEMIA
Heat stress increases all‐cause mortality, and is responsible for the death of thousands globally (Argaud et al., BET may improve acute heat tolerance both as an intracellular osmolyte and molecular chaperone. As an osmolyte, BET may increase intracellular fluid volume and minimize cellular hypertonic stress. Indeed, mammalian cells combat hypertonic stress by accumulating BET by upregulating the BET transporter (Alfieri et al., Furthermore, heat related injuries are partly attributed to endotoxemia, the presence of gut bacteria in the blood (Snipe et al., In fact, most of the research examining BET's role in thermal stress has been performed in cell culture and animal models experiencing passive heat stress. Collectively, these data tend to show evidence of reduced thermal stress when exposed to passive heat (DiGiacomo et al., 