Screening and randomization
viral infection, varicella-zoster virus, VZV
CYTOMEGALOVIRUS, VIRAL INFECTION
The eligibility of all autologous HSCT recipients newly admitted to HSCT ward was pre-screened by the researchers. Patients who were potentially eligible were recommended to participate in the current study. A signed consent form was completed by patients were willing to participate in the current study. Patients were screened for HSV IgG and IgM status and history of past viral infection for HSV, varicella-zoster virus (VZV), and cytomegalovirus (CMV). Patients who were finally confirmed eligible were subsequently randomized in a 1:1 fashion to either the study group (acyclovir prophylaxis group) or the control group (no prophylaxis). Randomization was stratified by HM (MM vs. lymphoma) and sex (male vs. female) to make even distribution of underlying HM and because male sex was an independent risk factor of CIOM in our previous study [