Background
chronic kidney disease, self-catheterization, urinary infections, insufficiency, urinary tract stones, voiding dysfunction
DISEASE, MCC, URINARY INFECTION
Underactive bladder is characterized by slow urinary flow, hesitancy straining to urinate, with or without a feeling of incomplete bladder emptying and elevated postvoid residual volume [The incidence of voiding dysfunction in children can be as high as 1/5 [To date, no traditional medicine has been shown to treat DU and restore bladder contractility. Thus, patients affected by this disease often experience an increase in the severity of the signs and symptoms.The main factors complicating treatment are high postvoid residual volumes, recurrent urinary infections, formation of urinary tract stones and even acute insufficiency that can progress to chronic kidney disease [Cell therapy (CT) with mesenchymal stem cells (MSCs) is a potential treatment. A previous study reported the autologous use of muscle-derived stem cells to treat bladder DU: the results demonstrated that the therapy is safe and reduces the maximum cystometric capacity (MCC), but the patient remained dependent on self-catheterization [As CT is still relatively unexplored in this area, the present research is the first to examine the evaluation of the effects of CT with adipose tissue-derived stem cells (ADSCs) in the treatment of DU among men.