4.1. Significant Effect on Lipids
heart disease, cardiovascular events, stroke, natto, CAD, TG, dyslipidemia
HEART DISEASE, STROKE, EVENTS, ATHEROSCLEROSIS, CAD, DYSLIPIDEMIA
In humans, high levels of TG in the bloodstream have been directly linked to atherosclerosis, a risk factor for heart disease and stroke. It is well established that TC, TG, LDL-C, non-HDL-C, and HDL-C are important factors against cardiovascular events [Our study found that the NMSs significantly (Low HDL-C levels are associated with an elevated risk of cardiovascular events and mortality in CAD patients [The precise mechanism by which NMSs favorably impact lipid levels remains unclear. Based on these observations, we hypothesize that the beneficial effects of NMSs in patients with dyslipidemia may be due to the combined effect of natto and red yeast rice increasing the activity of monacolin K, which inhibits HMG-CoA reductase, the rate-limiting enzyme for cholesterol synthesis, and thus effectively lowers cholesterol levels [