1. Introduction
hypothermia, hesperetine-7-Thermosensation, inflammation, hyperthermia, coldness
VASODILATION, OXIDATIVE STRESS, COLD, INFLAMMATION
Hesperetin, a citrus flavonoid, exerts vasodilation and is expected to improve endothelial function and alleviate cold sensation by activating nervous system thermal transduction pathways. In this randomized, double-blind, crossover, and placebo-controlled study, the purpose was to assess the effect of an orally administered highly bioavailable soluble inclusion complex of hesperetine-7-Thermosensation is a sensory process. Harsh environmental conditions can rapidly lead to harmful hypothermia or hyperthermia [In general, the cold sensation is the feeling of coldness at temperatures that are normally not considered so cold by the majority of people. Such epidemiology (so-called Certain dietary foods (such as seasonal fruits, beets, nuts, garlic, red-hot peppers, and some sea foods) play a vital role in blood flow [Hesperidin and its aglycone have been studied for their potential health benefits, including their ability to improve blood flow in the body by reducing inflammation and oxidative stress in the body, which can improve the health of blood vessels. The flavonoids hesperidin and hesperetin increase endothelial function via increased NO production, synthesized by the enzyme endothelial nitric oxide synthetase (NOS) [In this study, we performed a short-term cold provocation test among healthy individuals to confirm the efficacy of a highly soluble proprietary formulation of hesperetin-7-