2.1. Study Participants
post-prandial endotoxemia
This randomized controlled prospective human intervention study in crossover design was approved by the Ethics Committee of the University of Vienna (reference number: 00585) and was carried out in accordance with the ethical standards laid down in the Declaration of Helsinki. Originally, it was planned to investigate the effect of an acute (only once) and a two-day long intake of sucralose and sucrose on post-prandial endotoxemia in healthy subjects. Due to the COVID-19 pandemic situation and the associated restrictions, we were not able to conduct the study as originally planned and therefore focused on the acute intervention only. The study is registered at ClinicalTrials.gov (NCT04788680) and obtained approval to be carried out between 2021 and 2022. Sample size was calculated based on previous studies [