Ineligible or unavailable domains
allergies
ADVERSE EVENTS, SECONDARY, ALLERGIES
A participant may be ineligible for a specific domain because of contraindications (e.g. allergies, intolerances, adverse events) or non-contraindications (e.g. lack of access, clinician discretion, site opted out of domain). Domain ineligibilities will be incorporated by including the If response-adaptive randomisation is used and a participant is ineligible for one or more interventions within a domain, assignment probabilities will be re-normalised across the remaining eligible interventions, as long as there are a minimum of two eligible interventions within that domain that are available to the participant. If an intervention within a domain is unavailable at the time of randomisation for site-specific reasons (e.g. temporary lack of access to the intervention drug), then assignment probabilities will be re-normalised across the remaining available interventions, as long as there are a minimum of two eligible interventions within that domain that are available to the participant. Data on both the primary and secondary endpoints in participants flagged as ineligible (refused) for some or all interventions will still be captured and available for analysis.