Gavo-cel expansion, persistence and tumor infiltration
Serosal effusion, tumor, peritoneal tumor, Tumor
TUMOR, INFILTRATION, MALIGNANT EFFUSION, TUMOR, EFFUSIONS
The post-infusion expansion and persistence kinetics of gavo-cel are displayed in Fig. Trafficking of gavo-cel into tumor tissue or malignant effusions was evaluated in five patients. Tumor lesions collected at autopsy from patient 2 at 34 d after infusion showed clearly detectable levels of TRuC-T cell infiltration in two of five analyzed lesions: a peritoneal nodule (4,928 copies per μg of gDNA) and a heart nodule (4,473 copies per μg of gDNA). Notably, the gavo-cel transgene had become undetectable in peripheral blood by day 27, and no transgene was detected in normal lung adjacent to tumor lesions. Serosal effusion samples collected after infusion from four patients showed clearly detectable levels of TRuC-T cells. The peritoneal tumor nodule from patient 2, and effusions from patients 7 and 14, showed a much higher TRuC-T cell detection signal when compared to blood samples collected at the nearest proximal timepoint and at the time of peak expansion (Fig. 