Perioperative Systemic Therapy
At physician’s discretion, perioperative systemic therapy comprised either six two-weekly neoadjuvant and six two-weekly adjuvant cycles of FOLFOX (5-fluorouracil, leucovorin, oxaliplatin), four three-weekly neoadjuvant and four three-weekly adjuvant cycles of CAPOX (capecitabine, oxaliplatin), or six two-weekly neoadjuvant cycles of FOLFIRI (5-fluorouracil, leucovorin, irinotecan) followed by either six two-weekly adjuvant cycles of 5-fluorouracil with leucovorin or four three-weekly adjuvant cycles of capecitabine.