Specific Aim 1 – Primary outcome
weight loss, diabetes
REGRESSION, DIABETES
Hypothesis: The intervention will result in a greater proportion of participants achieving ≥ 5% weight loss at 12 months as compared to patients receiving usual care.For the primary analysis, we will use logistic regression to compare the proportion of participants with ≥5% weight loss between the two study arms at 12 months. The model will include indicator variables for study arm, SDM provider type (UCLA pharmacist vs. Intermountain registered nurse), and pre-selected baseline patient characteristics such as age and race/ethnicity. Given potential differences in intervention effectiveness across sites, we will conduct preliminary analyses within each site. Effect estimates for the intervention and relevant baseline covariates, if any, from the two models will be compared. Those with relatively large differences indicate potential interaction effects with site (i.e., site is an effect modifier). We will not draw final conclusions from these preliminary analyses, but in the formal analysis which combines data from the two sites, we can test interaction effects between site and intervention, and between site and other covariates as indicated by the preliminary analyses.We used data from prior work in SDM for diabetes prevention to estimate the effect size of the proposed intervention [