Author contribution
Line Skarsem Reitlo contributed to the data quality control, statistical analysis, figures, drafting, and revision of the manuscript. Jelena Mihailovic performed the MRSI data analyses, wrote methods, and revised the manuscript. Dorthe Stensvold and Ulrik Wisløff supervised the RCT Generation 100 study; were responsible for exercise, health, and clinical data collection; and revised the manuscript. Fahmeed Hyder supervised MRSI analyses and revised the manuscript. Asta Håberg supervised the MRI substudy in Generation 100, organized the data collection, collected data, performed statistical analysis, and drafted and revised the manuscript.