Statistical analysis
SSNS, illness
REGRESSION, REMISSION
Continuous data were presented as the mean ± standard deviation (SD) or median (range), according to distribution. Normal distribution was tested using histograms and QQ-pots. Discrete data were presented as frequencies and proportions (%).Total and subscale PedsQL scores were calculated for each age category. Differences between children with SSNS (SSNS group) and reference group were tested by an independent t test. The proportion (%) of children with impaired HRQoL, based on a score of ≥ 1 SD below the mean of the reference group, were compared by Fisher’s exact test. Individual items scores were presented as proportions (%). For each SDQ (summary) subscale, scores were calculated per age group. SDQ scores of the SSNS and reference group were compared using a one-sample t test. To quantify the differences, effect sizes (Cohen’s Multiple linear regression models were used to identify associated variables with PedsQL and SDQ scores. First, the following variables were tested by univariate analyses: child’s age and sex, older age ate onset (above median), parent’s country of birth (Netherlands/Belgium versus other) and educational level (low, intermediate, or high), time-to-remission, late remission (above median), illness in the past 4 weeks, school absence in the past 4 weeks, > 1 week of illness, > 1 week of school absence, the presence of any and pre-specified steroid side-effects (if present in ≥ 25% of the children), and the use and number of medications. Variables with a Data were analyzed using IBM SPSS Statistics for Windows [