Discussion
ADVERSE REACTIONS, ADVERSE REACTION
The present study was designed to evaluate whether vitamin B6 can alleviate the adverse reactions caused by the quadruple anti-Minocycline combined with metronidazole, bismuth, and PPI is an excellent treatment for patients with According to previous research, we speculate that the alleviation of adverse reactions may be because vitamin B6 drives the production of GABA in the brain by regulating glutamate decarboxylase [Our study has several limitations. First, it was a single-center clinical study with a small sample size. Although based on our research data, the sample size has met to the minimum standard. We should appropriately expand the sample size while considering the missing rate. And further double-blind trial studies with larger sample sizes are needed in the future. Second, we speculate that the mechanism of vitamin B6 of reducing adverse reaction may be related to the production of GABA in the brain, which needs to be proved by further experiments. Third, previous studies suggest that the eradication rate of minocycline regimens is up to 80% [To the best of our knowledge, this is the first study to explore whether vitamin B6 can alleviate the adverse reactions of the quadruple anti-In conclusion, we have shown that the effect of 