Efficacy Assessments
depressive symptoms
Efficacy was assessed by the Montgomery-Åsberg Depression Rating Scale (MADRS; range, 0-60; higher scores indicating more severe depressive symptoms) and Clinical Global Impression–Severity (CGI-S; range, 1-7; higher score indicates greater severity of illness) at 40 minutes; 2, 4, and 24 hours; and 1, 2, 4, and 6 weeks after infusion. Recalling time of MADRS general version is 1 week. In this regard, the structured interview guide for MADRS was used at 4 and 24 hours with its corresponding version (only these versions were available before this study), since such guides have previously been shown to increase the reliability of given scales and to ensure the accuracy of assessment a short time after infusion.