Follow-up
Toxicity
Each participant will undergo regular follow-up until 5 years following surgery for history and morbidity/toxicity assessment, physical examination, measurement of carcinoembryonic antigen (CEA), and assessment of questionnaires of QoL. Toxicity will be evaluated and recorded according to CTCAE v5.0. Furthermore, CEA will be measured at 3 months following surgery and every 6 months thereafter. Abdominopelvic and chest CT scans will be performed every 6 months during the first 2 years and then annually during the following 3 years. QoL assessment using EORTC questionnaires QLQ-C30 and QLQ-CR29, LARS score for all patients, and IIEF-5 for male patients will be performed at 3, 6, 12, and 24 months.