Patient cohort
PLASMA CELL INFILTRATION
The plasma cell infiltration, as derived from BM biopsies, ranged between 4 and 100%, with a mean value of 42% (median = 38%). Cytogenetic data were available in 31 patients (89%), with high-risk cytogenetic abnormalities being detected in 8/31 (26%) of them. A combination of the ISS and cytogenetic data was available in 31 patients. Based on this, 17 patients were classified in the R-ISS-1 group (55%), 11 patients in the R-ISS-2 group (35%), and three patients in the R-ISS-3 group (10%). The patients’ characteristics are summarized in Table 