Background
Schizophrenia, schizophrenia, first-episode psychosis, inflammation
CARDIOVASCULAR DISEASES, INFLAMMATION, REMISSION, CARDIAC EVENTS, INFLAMMATORY DISEASE
Schizophrenia is widely considered to be an inflammatory disease associated with chronic neural and systemic inflammation. Pro-inflammatory cytokines play a role in neurogenesis [The clinical impact of antipsychotics differs depending on patient sex [The neutrophil-to-lymphocyte ratio (NLR) is a reasonably good marker of systemic inflammation that correlates with cardiac events and mortality related to many cardiovascular diseases [NLR is increased relative to the general population in both first-episode psychosis and chronic forms of schizophrenia [The monocyte-to-lymphocyte ratio (MLR) and the platelet-to-lymphocyte ratio (PLR) are two other accessible blood biomarkers. Though they are less well-studied than the NLR, some reports suggest that they also may reflect inflammatory/anti-inflammatory processes in schizophrenia and its treatment. All three markers show higher levels in schizophrenia during relapse than during remission [We conducted a previous clinical trial with schizophrenia patients [