Discussion
cataract, occlusion of the internal carotid artery, reduced ocular blood flow, glaucoma
OPTIC NERVE, RETINA, CATARACT, GLAUCOMA, AGE-RELATED MACULAR DEGENERATION, PATHOGENESIS
Figs In the present study OR was estimated from AL based on an invasive study on cataract patients that found a strong negative correlation between OR and the natural log of AL [OIS occurs in patients with partial or total occlusion of the internal carotid artery on the same side as the affected eye. Poor collateral circulation between the internal and external carotid arteries usually accompanies the OIS diagnosis [While the complete pathogenesis of glaucoma is unknown, reduced ocular blood flow has been associated with the progression of glaucoma, as well as age-related macular degeneration [Sophisticated methods for measuring ocular blood flow have been developed, such as color Doppler imaging, Doppler Fourier domain optical coherence tomography, and laser speckle flowgraphy [Other limitations of this study relate to the data collection strategy of the original study. IOP was set manometrically, making the measurement of a μL-scale volume impossible. If an electronically controlled syringe pump had been utilized, then the actual pressure-volume relationship could have been recorded and compared with the estimated OR. However, this was not the primary goal of the study. Subject blood pressure was also not recorded.Finally, it should be noted that reduced blood flow in the choroid does not necessarily translate to reduced blow flow in the retina or optic nerve head. Choroidal blood flow is influenced by innervation of the sympathetic and parasympathetic nervous system where retina and optic nerve head blood flow are regulated locally [