Sample size calculation
Sample size calculation was performed using G*power software (version 3.9.6.2 for Mac OS). A total sample size of 42 patients was sufficient to detect an effect size of 0.25 at a power of 0.95 (95%) and a partial eta square of 0.06 at a significance level of 0.05. To account for dropouts, the sample size was increased by 20% to 52 participants