Genomic landscape of the NIBIT-M4 trial.
skin cancer, melanoma
SKIN CANCER, MELANOMA
Oncoplot of frequent somatic nonsynonymous and copy number alterations of NIBIT-M4 trial organized by response (columns, non-responder (NR, Solar ultraviolet (UV) radiation is one the main etiological factor for skin cancer, including melanoma as it causes a characteristic genomic mutational pattern associated with elevated TMB via the formation of pyrimidine-pyrimidine photodimers (COSMIC signature 7)Overall, our longitudinal analysis confirmed several genomic features previously associated with response to ICI, such as defects in the EMT, mutations of 