Biodistribution and dosimetry estimation
DECAY
Visual analysis was applied to determine the integral biodistribution of the tracer as well as the transient and intersubject stability. For each subject, regions of interest (ROIs) were delineated over the identified organs: the heart, liver, lungs, kidneys, pancreas, spleen, brain, thyroid and salivary glands. The geometric mean count was determined for every organ from the background-corrected anterior and posterior counts. The results are expressed as a percentage of the initial injected activity after decay correction (%ID/organ). For dosimetry estimation, absorbance dose of different organs and effective dose were calculated using OLINDA/EXM 1.0 software (Vanderbilt, University, Nashville, TN, USA) as previously described [