Safety
toxicity
The MTD was determined to be 600 mg three times a week. Dose-level summary with DLTsNote: Four patients, 2 each at dose levels 150 and 600 mg, missed more than 25% of the first 4 weeks of treatments. Therefore, 2 additional patients were recruited for each dose level.Abbreviations: DLT: dose-limiting toxicity.AEs of any grade were reported in 20 of 21 patients (95.2%; Summary of all AEs (