Interventions
Participants are randomized into either one out of the three approaches (exp. I–III). Three randomizations take place—one for each experiment. Patients are randomly assigned to receive either first verum then placebo, or vice versa. The randomization lists were created using RANCODE professional 2015. Randomization is performed block-wise. The randomization list was provided to the pharmacy for blinding, labelling and distribution of trial medication. For the case of emergency unblinding, a second set of sealed envelopes includes the information on the type of medication for each randomization number and is stored at the trial site. The integrity of the envelopes is monitored until end of study.