Effect of vitamin K1 and MK-4 on bone mineral density (BMD)
Lumbar spine (LS)BMD
There was no significant difference between the vitamin KThere were no significant differences in BMD between the vitamin KPlacebo
Vitamin K
MK-4
Lumbar spine (LS)BMD (g/cm0.760(0.085)0.775(0.087)2.11(5.80)0.790(0.101)0.796(0.105)0.59(3.06)0.793(0.100)0.802(0.116)1.00(4.06)

Femoral neck (FN)BMD ( (g/cm0.619(0.090)0.633(0.095)1.19(5.57)0.617(0.088)0.625(0.089)1.44(5.59)0.643(0.105)0.646(0.109)0.50(3.18)

Total hip (TH)BMD (g/cm0.744(0.092)0.745(0.095)-0.23(2.35)0.736(0.093)0.742(0.096)0.71(3.27)0.761(0.089)0.761(0.094)-0.04(2.63)

Placebo
Vitamin K1
MK-4
Lumbar spine (LS)BMD0.765(0.083)0.775(0.090)1.23(3.35)0.789(0.102)0.792(0.105)0.46(3.05)0.790(0.097)0.804(0.112)1.65(3.49)

Femoral neck(FN)BMD0.625(0.086)0.630(0.095)0.73(5.09)0.618(0.088)0.622(0.092)0.77(3.92)0.649(0.106)0.653(0.109)0.59(3.12)

Total hip(TH)BMD0.745(0.094)0.743(0.095)-0.28(2.38)0.738(0.095)0.740(0.099)0.24(1.84)0.769(0.085)0.768(0.090)-0.17(2.59)

Table 2A and B represent intention to treat (ITT) and per protocol (PP) analysis respectively, 