Discussion
MP, ARDS
ARDS, RECRUITMENT
In this randomized crossover trial, we found a significant decrease in MP using EIT-guided PEEP titration compared to High-PEEP/FiOZhao and colleagues reported that EIT-guided PEEP titration was associated with improved respiratory mechanics [He and colleagues compared the effects of EIT-guided PEEP titration vs. a low PEEP/FiOIn patients with ARDS, persistent elevation of MP > 17 J/min is associated with higher mortality [Our findings are consistent with previous observations [Our study has several limitations; 1) excluding subjects on prone positioning could have introduced post-randomization selection bias. 2) Sample was small, but the effects in MP reduction were significant and occurred despite optimal LPV at baseline. This suggests a strong effect of EIT in reducing MP. 3) We did not include a washout phase. However, our analysis considered the order of interventions to assess for carryover effects. 4) We did not assess for recruitability before the recruitment maneuver. This could have impacted sample’s enrichment. 5) Our intervention focused on titrating PEEP during the initial 24 h. However, PEEP/FiO