Conclusion
toxicity, GEP-NET
In summary, everolimus and temozolomide may be a treatment option for selected patients with metastatic GEP-NET G3 resulting in a high DCR at 6 months of 77%, PFS 12.6 months, and OS 31.4 months. The benefit for the few GEP-NEC patients was limited. Careful monitoring of toxicity is essential when using this combination, but toxicity did not compromise QoL.