1. Introduction
Obesity, obesity, cancer, metabolic inflammation, hypoxemia
OBESITY, OBESITY, OBESE, CANCER, DEGENERATIVE, DYSFUNCTION, METABOLIC DISORDERS, CHRONIC INFLAMMATION, OXIDATIVE STRESS, DISEASES, COMPLICATIONS
These authors contributed equally to this work.Background: The aim of this study was to determine the effect of using an oxygen-enriched breathing mixture during controlled physical training on blood oxidative stress parameters and total phenolics (TP) concentrations in obese adult women. Methods: A prospective randomized controlled trial study included 60 women aged 19–68 with BMIs greater than 30 kg/mThe processes of proper oxygen supply to tissues and cells, the control of mediators of the inflammatory process, and balance in the oxidation–antioxidation system occur simultaneously in living organisms in close interdependence with each other. Appropriate balance between them is a prerequisite for health and wellbeing. The dysfunction of any element entails changes in the others, leading to the development of a wide variety of diseases ranging from cardiovascular conditions, metabolic disorders, degenerative processes, neurodegenerative processes, and finally, cancer [Obesity is a condition which in itself induces oxidative stress, and the coexistence of hypoxemia and chronic inflammation further exacerbates its effect. De Ferranti and Mozaffarian demonstrated an increase in malondialdehyde (MDA) levels in the fatty tissue of obese individuals, which is manifested by the presence of lipid peroxidation processes of cell membranes in these patients [The aim of treating obesity is to compensate for energy balance through diet and exercise. Only in this way can we reduce metabolic inflammation and oxidative stress and reduce the burden that excess weight places on many systems, including the cardiovascular, respiratory, and osteoarticular ones. Currently, there are three main methods of treating obesity: the method of changing dietary habits connected with applying physical exercise, the use of pharmacotherapy, and surgical treatment. The last two methods of treatment carry a high risk of complications or side effects, and the results are not always satisfactory.The aim of this study was to determine the effect of using an oxygen-enriched breathing mixture during controlled physical training on the total phenolics concentration in plasma and oxidative stress indices in obese female patients. We hypothesized that the controlled use of oxygen therapy as a supportive measure in the treatment of obesity would not cause oxidative stress in the examined women.