Sample size
muscle mass
The sample size was determined by the power calculations for the muscle strength and mass. Using one‐sided test and alpha at 0.05, sampling ratio 1, superiority margin of 0.001, to test the superiority of the intervention, 160 patients (80 patients per group after adjusting for 5% drop‐outs) were required for 80% power for detecting increase in muscle strength or muscle mass in at least 25% patients in the intervention group and ≤10% patients in the control group. An increase of 3% in muscle mass represented a minimum expected change.