Statistics
The distributions of protein changes were examined with the Shapiro–Wilk test. Most changes were skewed; thus, non-parametric tests were used for the analyses. The changes within the study groups were analyzed with the Wilcoxon test using the Benjamini–Hochberg procedure to control false discovery rates.To investigate the differences between the study groups, we calculated the difference between the baseline and 9 weeks for all proteins. These differential variables were then analyzed with the Kruskal–Wallis test and the Benjamini–Hochberg procedure. Statistically significant results were further compared with the Mann–Whitney 