Safety reporting
ADVERSE EVENTS, ADVERSE EVENT, ADVERSE EFFECTS
Adverse events are defined as any undesirable experience occurring to patients during the trial, whether or not related to NAC. The patients were entirely justified about the side effects of NAC or for taking medication and placebo. All patients were requested to inform investigators about any complaints and adverse events during the clinical trial. The signs were recorded at the beginning and each session. Also, possible adverse effects were recorded via telephone call every week and the expert physician was responsible for discontinuing or continuing the drugs.