Author contributions
RECRUITMENT
F.M. coordinated the translational axis of the study and contributed to the writing. L.L.B. performed the artificial intelligence analyses. A.L. and T.F. ran all statistical analyses of the study. E.D., A.D., B.P., T.B., F.V. and C.L. were involved in recruitment, clinical care and data returns. Y.P., B.J. and M.D. performed bioinformatics analyses. V.M., N.S. and A.A. did the Multiplex IF analyses. I.J.G. participated in artificial intelligence analyses. H.T., S.C. and M.V. supervised the artificial intelligence analyses. D.T.N.T., N.D. and A.S. performed the genomic analyses of the trial. M.K. and T.K. performed the T-DXd distribution experiments at Japan. L.L. and P.S. did the RT–PCR analyses. M.J. and C.M. are the project managers of the DAISY trial and centralized the collected samples and data. V.B., P.L. and P.K. performed the in vitro experiments for 