Outcomes
dysuria, Dysuria, pain
ADVERSE EVENTS, SECONDARY
The primary outcome was the improvement of dysuria, evaluated as the percentage of participants presenting an excellent clinical response, defined as an improvement in symptoms from mild, moderate, or intense to absent, from 0 to 24 h after treatment.Dysuria was divided into three components: pain, burning, and burning on urination, and participants used the categorical seven-point scale and a 100-mm visual analog scale (“0” = absence of the symptom and “100” = maximum intensity) to report symptoms.The secondary outcomes were:Percentage of participants with an excellent clinical response at 12 h, 36 h, 48 h, and 72 hTime to reach absence of symptomsSustained healing—defined as the absence of pain after 72 hImprovement of dysuria by the investigator using the Clinical Global Impression (CGI) scale, which consisted of two subscales, the severity (CGI-S) and the improvement (CGI-I) [Urine culture at the end of the treatmentSafety, by the incidence of adverse events (AEs)