DISCUSSION
impaired microvascular function
OXIDATIVE STRESS
We performed a randomized controlled crossover trial in young, healthy, normotensive adults to evaluate the effect of melatonin during a HSD on vascular function. Melatonin has been shown to have antioxidant‐like properties and has been effective in reducing oxidative stress in clinical populations as well as improving cardiovascular biomarkers (Kedziora‐Kornatowska et al., We measured vascular function following 10 days of a HSD, achieved using salt pills. Previous work using salt pills to increase sodium intake over 10 days has shown a reduction in brachial artery FMD in young healthy adults compared to a recommended sodium diet (Babcock et al., Microvascular function was evaluated using NIRS‐VOT in addition to FMD. Changes in the microvasculature can often present before changes in larger conduit vessels highlighting the importance of examining the microvasculature (Holowatz et al., We have previously demonstrated that ROS scavengers can mitigate impaired microvascular function imposed by a HSD using a controlled feeding study approach (Greaney et al., 