Authors’ contributions
UC
AYM, ER, GT, HZ, AK, IS1, and IS2 conceptualized the DIRECT PLUS and performed the data collection. AYM made the statistical analysis, interpreted the data, reviewed the literature, and drafted the manuscript. AYM, MK, AH, and TH performed the sample processing. MK performed the DNA quality and quantification. BE, URK, SBH, and MVB performed the urine polyphenol measurements. UC and BI performed the laboratory analyses. JL and LL established the methylation age prediction by age. All authors contributed to the interpretation of the data and reviewed this work’s language and intellectual content. AYM, MK, MS, MB, FBH, MJS, PK, LL, and IS2 revised the final draft of the study. All authors read and approved the final manuscript.