Study procedures
psychiatric
BLOOD
All volunteers attended a screening visit to determine eligibility to be enrolled in the study. During this visit, a physical examination (weight, ECG, blood pressure, heart rate (HR) and neurological examination) and routine blood test were performed, as well as a psychiatric interview (see ‘Participants’ for exclusion criteria). Subsequently, volunteers provided informed consent to be enrolled in the study and completed questionnaires.The dosing visits took place in a calm, decorated hospital room at Imperial College Research Facility. On dosing days, two research staff, one medic, and one research subject were present. Subjects were reminded of the study procedures and were asked to verbally provide re-consent if they wished to continue. Urine screens for drugs of abuse and pregnancy were performed. Participants were fitted with an EEG cap, an ECG was taken (to ensure safety), and cannulation took place on both arms. Blood samples were drawn from one cannula, and continuous infusions of DMT/placebo were administered via the other cannula. Participants were made comfortable in a semi-supine position and baseline EEG recordings were taken (eyes open and eyes closed). Shortly before dosing started, a body scan meditation was performed to help participants relax. During dosing, participants wore an eye mask and were instructed to keep their eyes closed. Low-volume ambient music (