PREDIMED-Plus study
cardiovascular disease, cardiovascular diseases, cancer, PREDIMED-Plus, motivational behavior
CANCER, EVENTS, CARDIOVASCULAR DISEASE, CARDIOVASCULAR DISEASES
PREDIMED-Plus is a multicenter, randomized controlled trial in Spain assessing the effectiveness of an intensive lifestyle intervention on the primary prevention of cardiovascular diseases in comparison to usual care in 6874 community-dwelling older adults (women and men, aged 55–75 years). A detailed study protocol has been previously published [At enrolment, participants were free from cardiovascular disease and active cancer. The PREDIMED-Plus study hypothesizes that an intensive lifestyle intervention that encourages energy reduction with a high-quality Mediterranean dietary pattern and increased physical activity with motivational behavior support will have a larger reduction in the risk of hard cardiovascular events compared to usual care encouraging a Mediterranean diet [The PREDIMED-Plus cohort has scheduled baseline and annual follow-up anthropometric, dietary, and physical activity data providing a cumulative assessment of the exposures before the COVID-19 pandemic. The documentation of sociodemographic and health data in the PREDIMED-Plus study also facilitates adjustments for potential confounders, making the study database well-suited to explore the prospective association of anthropometric parameters and their changes over time with the risk of COVID-19 incidence.