Treatment and procedures
Tumor, Cancer
TUMOR, CANCER
Patients were randomized (2:1) to receive oral afatinib 40 mg/day for 21 to 28 days (Arm A) or no treatment (Arm B) before surgery. Surgery was not delayed as compared to standard of care. Tumor biopsies were collected during baseline endoscopy and surgery. FDG-PET scans were performed before the endoscopy, and at day 15 after treatment initiation. FDG-PET scans examinations were performed on the same system at baseline and before surgery, and assessed by central imaging review (FDG-PET unit of the François Baclesse Cancer Center) as per the EANM guidelines