References
Hepatitis A-, fatigue, psychiatric illness, allergy, arthritis, drug abuse, hepatitis, neurological disorders
RECRUITMENT, ALLERGY, ARTHRITIS, HEPATITIS, NEUROLOGICAL DISORDERS
General schematic of trial design.Recruitment flow chart.NPN_1 group had significantly increased strength recovery post-strenuous exercise over the hour period post-resistance exercise, but not at individual timepoints. (NPN_1 significantly relieves fatigue and allows a return to performance. (NPN_1 supplementation alters plasma myokine concentrations, increasing myokines associated with glycogenesis and protein synthesis, whilst decreasing those associated with negative regulation of protein synthesis. Serum myokine expression following intense exercise is altered with supplementation with NPN_1. Analysed by repeated measures ANOVA. (Subject inclusion and exclusion criteria.Males between 30 and 45 years of age.Participants agree to abstain from taking additional supplements throughout the testing period, with particular emphasis placed upon protein-based products.Participants agree to maintain their normal diet and exercise routine throughout the study.BMI between 18.5 and 29.9 kg/mParticipants agree to refrain from consuming alcohol in the 48 h leading up to a test day.Willingness to complete questionnaires, records and diaries associated with the study and to complete all clinic visits.Provide voluntary, written, informed consent to participate in the study.Refrain from any sort of exhaustive physical exercise from 48 h prior to each test or blood draw.Healthy as determined by medical examination at screening visit.Willingness to complete food diaries during the study.Must have a smart phone to use the Nutritics App.Non-smoker.Alcohol or drug abuse in past year.Participation in any other clinical trial in the past 3 months from time of randomisation.Volunteer has a known allergy to the test material’s active or inactive ingredients.Volunteers with unstable medical conditions.Any complaints that could interfere with ability to exercise.Individuals who are cognitively impaired and/or who are unable to give informed consent.Any co-morbidities interacting with mobility or muscle metabolism of the lower limbs (e.g., arthritis, spasticity/rigidity, all neurological disorders, paralysis).Creatine supplements, anticoagulants, corticosteroids, growth hormones.Presence or history of neurological disorders or significant psychiatric illness.Any other condition which in the investigator’s opinion may adversely affect the volunteer’s ability to complete the study or its measures or which may pose significant risk to the volunteer.Participation in resistance or aerobic exercise within 48 h of the test days.Participation in >3 high-intensity exercise sessions per week.Undertake no recovery methods such as sea swims, foam rolling, cryotherapy or undue stretching during Days 14–17.Have been in contact with a suspected or confirmed case of COVID-19 in the previous 14 days.Are Hepatitis A- or B-positive, HIV-positive or have had a sexual partner who is infected with hepatitis or HIV.Population allocation adjudication results based on exclusion criteria.Anthropometric data (mean ± SD).