Introduction
primary bile acid chenodeoxycholic acid, Hyperbilirubinemia
NEONATAL DISORDERS, NEONATAL HYPERBILIRUBINEMIA, HYPERBILIRUBINEMIA
Hyperbilirubinemia is one of the most common neonatal disorders, especially in the first week after birth, which occurs in half of term and most preterm infants [Ursodeoxycholic Acid (UDCA) is a type of hydrophilic bile acid that accounts for about 4% of bile acids in humans and is synthesized by bacterial enzymes in the gallbladder from primary bile acid chenodeoxycholic acid. During oral administration, almost half of the drug, is absorbed in the intestine and enters hepatocytes through the portal circulation. UDCA significantly reduces the secretion of cholesterol into the bile [It is noteworthy that pediatricians have to be assured about the safety profile of drugs used for neonates. Although some previous studies mentioned the positive effect of administering UDCA on neonatal hyperbilirubinemia [