Explanation for choice of comparators {6b}
®
ADVERSE EFFECTS
We will compare adverse effects among the three treatment groups: oxycodone, Bediol®, and the combination of Bediol® and oxycodone. The main reason is that we expect that combining Bediol® with oxycodone will reduce opioid side effects both during treatment and following treatment, i.e., we expect less withdrawal symptoms. We expect that this may partly be due to the expected reduction in opioid dose during Bediol