Outcomes of interest
The primary endpoint was the change observed in glucose disposal (Gd) from pre-treatment measurement to post-treatment assessment, as measured during a hyperinsulinaemic clamp (low-dose insulin). The decision used Gd at low insulin infusion rates was made to try and balance the counteracting effects of prednisolone against the very potent impact of insulin. Published data have shown that prednisolone suppresses Gd at low dose, but not high-dose insulin