Introduction
tooth, alveolar bone resorption, tooth loss, periodontitis, Periodontitis
INFILTRATE, PERIODONTITIS, AIDS, DENTAL PLAQUE, GINGIVAL BLEEDING, PERIODONTITIS, ALVEOLAR BONE LOSS, INFLAMMATORY DISEASE
Periodontitis is a chronic multifactorial inflammatory disease caused by dysbiotic dental plaque biofilms with the formation of an inflammatory infiltrate that contributes to destruction of connective tissue attachment to the tooth, alveolar bone resorption and may result in tooth loss [Primary clinical features of periodontitis include the loss of periodontal tissue support, which manifests through clinical attachment loss and radiographically assessed alveolar bone loss with the presence of gingival bleeding and periodontal pockets [Recent systematic reviews have provided some evidence indicating that adjunctive aids, in conjunction with mechanical debridement, might enhance the outcomes of non-surgical periodontal therapy [HA is a naturally occurring biodegradable polymer that is responsible for several structural properties of tissues as a component of the extracellular matrix [Recently, a novel concept consisting of enhancing biofilm removal during nonsurgical therapy by means of a sodium hypochlorite/amino acids followed by application of a cross-linked hyaluronic acid gel (xHyA) gel was suggested as a novel strategy to improve the outcomes of nonsurgical periodontal therapy [However, to the best of our knowledge, at present no randomized controlled clinical trials have evaluated the potential clinical relevance of this novel concept as compared to mechanical debridement alone.Therefore, the aim of this randomized controlled clinical study was to compare the clinical outcomes obtained with either mechanical subgingival debridement in conjunction with sodium hypochlorite/amino acid gel followed by subsequent application of xHyA, or with mechanical debridement alone.