Outcomes
manic
REMISSION
The primary outcome was the response rate at 2 weeks, with response defined as a 50% reduction in the MADRS. Secondary outcomes included the response rate at 6 weeks, remission rates at 2 and 6 weeks, and a change in MADRS and CGI-S score from baseline to 6 weeks, with remission defined by a MADRS score of 10 or lower. Safety outcomes included general side effects, psychotogenic effects, dissociative effects, manic symptoms, and suicide risk.