Author contributions
RECRUITMENT
FS: had full access to all data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. FS, RUN, DAG, and DRT: contributed to the study conception and design. Patient recruitment was contributed by FS, JT, MB, EO, and DH. Material preparation, data collection and analysis were performed by FS, RUN, DAG, DRT and PL. The first draft of the manuscript was written by FS: and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.