Mobilization of immunoregulatory T cells to the peripheral blood
In the mid-dose group (0.01 mL/kg), the numbers of CD3Lymphocyte mobilization with MRG-001 in healthy subjectsSubjects received SC injections every other day of saline (placebo control), mid-dose (0.01 mL/kg), or high-dose (0.02 mL/kg) MRG-001 (n = 4/group). Venous blood was collected and PBMCs were isolated at different time intervals on day 1 after a single dose SC injection of saline or MRG-001 and on day 5 after the third dose. Lymphocyte populations (CD3(A) Lymphocyte populations in peripheral blood on day 1 after a single dose SC injection of saline or MRG-001.(B) Lymphocyte populations in peripheral blood on day 5 after the third dose. Each value represents the mean ± SD.Yellow marked cells represent significant difference with p < 0.05.At day 5 (0 h, before the third dose), the numbers of CD3To better reflect the immune balance during mobilization, the ratio between Tregs and T cells was calculated (The mid-dose of MRG-001 consistently increased CD4