Statistical analysis
Data analysis was performed by SPSS 24.0 software (SPSS Inc., Chicago, IL, USA). Qualitative variables were compared by Chi square (χ2) test and Fishers’ exact test between the two groups. Kolmogorov–Smirnov test determined distribution pattern of quantitative data. The normally and non-normally distributed data were presented as mean (SD) and median [IQR], respectively. Wilcoxon Signed Rank test was applied for comparison of values at the beginning and end of intervention within each group. Mann-Whithney U test was applied for comparison of baseline values between the two groups. ANCOVA test was performed to compare the post-intervention values between the groups with the control of baseline values as covariates. 