Recovery from ocular toxicity
ocular toxicities, uveitis, keratopathy, ocular toxicity
KERATOPATHY, BAND KERATOPATHY, UVEITIS, CONJUNCTIVITIS, DIM VISION
Drug administration was subjected to a temporary hold due to ocular toxicity in 22 cases. For patients with conjunctivitis, uveitis, and keratopathy, temporary hold of the drug was less frequent: 0 of the 1 patient with conjunctivitis, 0 of the 1 patient with uveitis, 4 of the 9 patients with keratopathy. Some patients were treated with eye drops and laser therapy. Except for three cases, all patients fully recovered from their ocular toxicities. Recovery was not confirmed in the three patients because the trial was stopped for two patients and one patient died; these patients experienced keratopathy due to an FGFR inhibitor, uveitis due to HER2-directed ADC, and dim vision (where patients see darker images) due to an HSP90 inhibitor (follow up time: 4–196 days) (Table Among 37 ocular toxicities in 33 patients, 19 cases recovered to grade 0 within 50 days from onset, while the patient with dim vision due to an HSP90 inhibitor required more than 400 days to recover.