Diagnosis of a dose-finding rule
toxicity, overdosed
Now, the fundamental question is this: given a dose-finding rule Next, we define a data generating distribution for simulating toxicity responses The distribution The eventual success of model-based dose-finding design relies on a dose-finding rule With cNumber of patients with DLT (NPD): Number of patients overdosed (NPO): Bias to MTD (BTM): Square root of the relative mean squared error (RMSE): The notation By evaluating the four metrics - Due to the small sample nature of phase I studies, a practically useful diagnosis of a dose-finding rule 