Acknowledgements
P.
A.J. and A.V.H.G. are joint first authors of this article. This study was managed by the Royal College of Surgeons Oxford Surgical Intervention Trials Unit (SITU; supported by Oxford NIHR Biomedical Research Centre) and conducted as part of the portfolio of trials in the registered UK Clinical Research Collaboration (UKCRC) Oxford Clinical Trials Research Unit (OCTRU) at the University of Oxford. It followed their Standard Operating Procedures, ensuring compliance with the principles of Good Clinical Practice and the Declaration of Helsinki, and any applicable regulatory requirements. The authors thank the trial sponsors, University of Oxford, staff at the SITU and OCTRU trial units, and the Reconstructive Surgery Trials Network who supported this trial; participants and their families, principal investigators and their teams at each of the NINJA sites; the independent trial steering committee—A. Karantana (Chair), C. Hewitt, G. Smith, S. Petrou, H. Connolly, R. Harman, R. Nandi; the Data Monitoring Committee—G. Lawton (Chair), A. Elders, D. Kennedy; and the patient co-applicants—D. Blanche and S. Snelling for their time and support throughout the trial. The following contributed to aspects of the study conduct: A. Riddell, A. Bonges, A. Diver, B. Tallon, C. Coapes, C. Harrison, D. Berwick, D. Miller, E. Pardoe, E. Glass, I. King, I. Yonjan Lama, I. Teo, J. Ting, J. Summers, J. Jeevaratnam, J. Luck, J. Ruston, K. Finlay, K. Nundlall, L. Kottam, M. Mikhail, M.-C. Miller, M. Singh, M. Kharashgah, M. Shahid Ikram, N. Silberras, N. Johnson, N. Modi, N. Mackie, P. Kumar Patel, R. Mistry, and R. Burton.An executive summary of the findings was sent to all trial participants. Once the findings have been published, the details will be provided to patient/public groups and professional organizations with a request to disseminate to their membership.