Associations between within-class FA plasma concentrations and CMD risk in EPIC-Potsdam
CMD, cardiometabolic disease, TG
The associations between within-class FAs affected by the replacement of dietary SFA with UFA in the DIVAS RCT and the long-term CMD risk in the EPIC-Potsdam cohort study are presented in Effect of the DIVAS dietary intervention on lipid metabolites identified in lipidome-wide screening and associations with cardiometabolic disease risk in the EPIC-Potsdam study. Assessed using multivariable Cox proportional hazard models adjusted for age (timescale); sex; waist circumference; height; leisure time physical activity; smoking status; alcohol intake; highest achieved education level; fasting status as blood draw, total energy intake, diastolic and systolic blood pressures, circulating total cholesterol, HDL cholesterol, and TG concentrations; antihypertensive medication; lipid-lowering medication; and acetylsalicylic acid medication. In addition, each model was adjusted for the concentration of the total lipid class to which the within-class FA concentration of interest belonged. 