Registration number
DISEASE
NTR 4821 (This multicentre non-inferiority RCT compared isolated ambulatory phlebectomy with or without delayed truncal ablation (SAP) and endovenous truncal ablation with concomitant phlebectomy (TAP). Based on disease specific health-related quality-of-life scores, SAP was non-inferior to TAP after 12 months’ follow-up. Treatment with SAP was shown to be a cost-effective alternative to TAP.