Outcome measures.
obesity, cardiovascular disease, diabetes
OBESITY, VIRUS, CARDIOVASCULAR DISEASE, DISEASE, CHRONIC RESPIRATORY DISEASE, SECONDARY, REGRESSION, HIGH BLOOD PRESSURE, DIABETES
The primary endpoint was time (days) to clinical improvement of subjective symptoms within 14 days. A four-point scale (0, none; 1, mild; 2, moderate; and 3, severe) was utilized for subjective symptom assessment (The secondary endpoints were time (days) to clinical improvement of subjective symptoms within 28 days, change from baseline in subjective symptom score, change from baseline in the ordinal scale, and proportion of clinical improvement in the ordinal scale. An 8-point ordinal scale was used in this study, where score 0 was for an uninfected patient state, 1 or 2 for ambulatory, 3 or 4 for hospitalized with mild disease, 5 to 7 for hospitalized with severe disease, and 8 for dead. An improved ordinal scale score was established when the ordinal scale score improved by 2 or more after the baseline among patients whose baseline ordinal scale score was 2 or higher.Subgroup analysis of the high-risk group was conducted, where the high-risk group included patients who were older than 60 years or had one or more risk factors such as cardiovascular disease, chronic respiratory disease, high blood pressure, diabetes, obesity, and smoking.The result of linear regression of the amount of virus (PFU/mL) was obtained using the lm equation of the R program (version 4.0.5).