Sample size calculation
ARDS
ARDS
A sample size of 90 patients was determined to demonstrate a 25% reduction in EVLWi, with 80% power and a type 1 error rate of 0.05. The calculation was based on an anticipated baseline EVLWi of 17 ml/kg with a standard deviation (SD) of 7 ml/kg. This was based on previously performed EVLW measurements in patients with moderate to severe ARDS [The study protocol (Additional file 