Acknowledgements
RECRUITMENT
Dr. Shahenda Shama had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. None of the authors has any potential conflict of interest, any relevant financial activities outside the submitted work or any other relationships or activities that readers could perceive to have influenced, or that give the appearance of potentially influencing, what is written in the submitted work at any time prior to submitting this work. No funding was received for this work. Ethical Committee of the Faculty of Medicine, Helwan university, approved this research in July 2019 with serial number 25/2019. IBR and ethical approval were granted prior to the study and consent was obtained from all participants. Dr. M. Elkomy and Dr. N. Bedair designed the study. Dr. S. Shamma was responsible of recruitment of participants, obtaining their consent, and administrating the therapeutic agents. All authors were responsible for following up the participants. Dr. M. Elkomy and Dr. Nermeen Ibrahim Bedair were responsible for literature review and preparing the draft for this manuscript. All authors approved the manuscript for publishing.