Feasibility outcomes
failure of breath synchronisation
All patients received all prescribed doses of surfactant. There were two episodes of delays in surfactant delivery due to issues relating to the device, one related to failure of breath synchronisation and one to breath-sensor failure. The devices were replaced immediately on both occasions and patients subsequently received their appropriate dose. No other device related issues were documented. The first two cohorts (cohort 1 + 2) had 10 surfactant vials delivered with a median nebulizer delivery time of 252 min (IQR 190, 283). The next two cohorts (cohort 3 + 4) had a reduced surfactant dose (5 vials) with a much shorter median nebulization duration of 87 min (IQR 70, 98).