Conclusions
CRSwNP
These psychometric analyses demonstrate that both the VAS and SNOT-22 have acceptable psychometric properties for outcome assessment in patients with very severe CRSwNP. Scores derived from both measures exhibited acceptable internal consistency and construct validity, in addition to test–retest reliability and known-groups validity (assessed only for the VAS). Overall, our analysis demonstrated that patients receiving mepolizumab were more likely to experience improvements in symptom severity and HRQoL versus placebo, when added to standard of care.