Global changes in gut microbiome during phase 1 and 2
To evaluate metformin and prebiotic mediated effects on the gut microbiome, we explored changes in beta diversity throughout the course of the study. Principal coordinate analyses revealed that during Phase 1 and Phase 2 there were overall trends for shifts in beta diversity (Principal component analysis of microbiome composition in Phase 1 and Phase 2. Trend for shifts in microbiome beta-diversity 