Participants
periodontitis, allergic, tooth loss, bone loss
PERIODONTITIS, DISEASES, HIV PERIODONTITIS, BONE LOSS
Male and female patients visiting the Department of Dental and Oral Pathology at the Lithuanian University of Health Sciences in Kaunas, Lithuania, were considered for enrollment.Patients with periodontitis (stage III–IV) were included in the study according to the 2017 World Workshop on the Classification of Periodontal and Peri‐Implant Diseases and Conditions.Patients with stage III and IV periodontitis with slow or moderate rate of progression (A/B) (radiographic bone loss extending to middle or apical third of the root, tooth loss due to periodontitis, maximum probing depth ≥6 mm, horizontal and vertical [≥3 mm] bone loss)Systemically healthy individualsThose with ≥20 remaining teethPatients aged 30 years or olderPatients were excluded if they:Had stage I and II periodontitis (radiographic bone loss in coronal third, no tooth loss due to periodontitis, maximum probing depth ≤5 mm, mostly horizontal bone loss)Had systemic disease(s)Had antibiotic therapy during the last 3 monthsHad periodontal treatment during the last 6 monthsWere pregnant or lactatingClaimed to be allergic to the adjunct (PACNs)