The role of CHW in the CANTAM-
malaria, HIV or viral hepatitis
MALARIA
The CANTAM-The trial was conducted at six centers in five African countries with the main objective to assess the safety of PA in malaria patients with underlying liver function abnormalities, comorbidities like HIV or viral hepatitis, and in children under 1 year of age To evaluate safety and real-world effectiveness, participants were primarily followed up by CHWs trained specifically in the trial procedures. Depending on the country's strategies, most CHWs were recruited either from a pre-existing pool or through structured processes set up by e.g., the Ministry of Health. CHWs needed to be rapidly deployable and serve as a mobile link between the participants living at varying distances from the study centers and the investigator teams. They provided oversight of participant safety while intervening as little as possible with the participants’ healthcare-seeking behavior to mirror the real-world patient-doctor interactions in the management of uncomplicated malaria.