Compliance with ethical standards
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the local Research Ethics Committee in Denmark (H-16,027,749) in accordance with Danish law and was registered at clinicaltrials.gov (identification number: NCT03203057). All included patients provided written informed consent.