D9-choline and its water-soluble downstream metabolites
Figure Plasma kinetics of D9-choline (By contrast, ingestion of D9-POPC resulted in delayed (Similarly, the kinetics and maximum concentrations of D9-betaine were different in response to D9-POPC compared to water-soluble compounds (Fig. Finally, the concentrations of D6-dimethylglycine (D6-DMG), the demethylation product of D9-betaine used for (D3-)methionine synthesis from homocysteine, was lower after D9-POPC ingestion compared to the other deuterium-labelled compounds (Fig. Plasma kinetics of D6-DMG (Panel A) and D9-TMAO (Panel B) in response to deuterium-labelled (D9-) choline supplements. Inserts also show concentrations over time, focussing on a shorter time period (9 h). Data are shown as medians and interquartile ranges. 