Meaningful change estimates for domain scores.
Meaningful change estimates for the PIB weekly mean and PIB weekly maximum domains were calculated using the PGIC anchor. For the Decision Tree score, the CGIS anchor was used instead. The correlation between the anchor and the change in domain score was determined by calculating polyserial correlation coefficient. Subjects were divided into groups based on their progression from Visit 1 to Visit 2. According to the anchor point used, the groups were defined as ‘Improved’ (very much improved, much improved, or a little improved at Visit 2) and ‘Stable’ (no change at Visit 2). Meaningful change estimates were determined within subjects (minimal important change) and between groups (minimal important difference). Data is displayed as the mean change score / mean difference score with the 95% confidence interval being displayed in brackets for each mean value.

minimal important changeminimal important difference