2.1. Trial design and oversight
ESSENTIAL HYPERTENSION
This was a randomized controlled study to determine the effect of Liuzijue exercise in different periods on the circadian rhythm of blood pressure in patients with essential hypertension. The Medical Ethics Committee of the Affiliated Hospital of Chengdu University of TCM approved the study(ethical review number: 2019KL-047). Prior to commencing the intervention, a comprehensive explanation outlining the precise objectives, methodology, intervention schedule, anticipated advantages, and potential risks of the study was provided to all participants. By rigorously adhering to the principle of voluntary participation, individuals were duly informed, and their consent was obtained through the signing of an informed consent form prior to their inclusion in the study. To ensure the safety of the participants, stringent termination criteria were applied and adhered to throughout the study. Throughout the intervention period, the participants retained their autonomy to withdraw from the study based on their individual circumstances. Participants’ personal information and related records were kept strictly confidential.