Discussion
VF, POAG, OAG, Glaucoma, NTG
OCULAR HYPERTENSION, GLAUCOMA
In this randomized controlled trial, we compared the short-term efficacy of primary single SLT with 0.005% latanoprost eye drops monotherapy for controlling 24-h IOP in treatment-naïve POAG and OHT. We demonstrated that both SLT and latanoprost eye drops significantly improved 24-h IOP control, including mean, peak, and 24-h fluctuation of IOP. However, latanoprost was more effective. In addition, the nocturnal IOP-lowering efficacy of the latanoprost eye drops was better than SLT during the 12-week follow-up.The Laser in Glaucoma and Ocular Hypertension Trial (LiGHT) study compared IOP lowering 355 OHT or OAG patients (611 eyes) who received SLT with 362 OHT or OAG patients (622 eyes) who received topical medication for two monthsLong-term IOP fluctuation is associated with VF progressionNagar et al.In Chinese patients with POAG, the percentage of those with NTG ranges from 51.43 to 83.58%This study also had some limitations that warrant discussion. First, GAT measurement in the sitting position was utilized at all time points during the 24-h IOP evaluation. This may fail to represent an individual’s actual IOP variation because people usually slept lying down. Interestingly, even though lying down or taking a head-down tilt position was known to impact IOP