Treatment effect of the outcomes analyzed at the end of the study.
pain
Independent t-test was used to evaluate sleep, quality of life and pain catastrophization. The participants answered to questionnaire on day 21 in the last treatment cycle.When assessing acceptability at the end of the study period 11 (61%) in the melatonin group had a good experience with the drug, 1 (6%) had a bad experience and 6 (33%) did not know. In the placebo group the reports showed 9 (56%), 3 (19%) and 4 (25%) respectively. 11 (61%) and 10 (62.5%) would recommend the study drug to a friend in the melatonin group and placebo group respectively. No statistically significant differences were seen between the treatment groups in regard to having had a good or bad experience with the drug or recommending it to a friend.