Phosphorylation‐dependent and Phosphorylation‐independent changes in cardiomyocyte stiffness in obese rats
OBESE
To investigate the interaction between the GGA‐mediated reduction in cardiomyocyte stiffness and phosphorylation‐mediated changes in FOral GGA treatment reduces the effect of protein kinase A (PKA) on cardiomyocyte stiffness in cardiomyocytes of obese ZSF1 rats. Isolated, permeabilized cardiomyocytes of lean, obese and GGA‐treated obese rats were incubated with exogenous protein kinase A (PKA; 1 unit/μL) and 3′,5′‐cyclic adenosine monophosphate (cAMP; 0.006 mM) over a 40‐min period at an optimal sarcomere length (SL) of 2.2 μm. (a) absolute F