1. Introduction
avolition, depression, treatment-resistant depression, anhedonia
SAID
Repetitive transcranial magnetic stimulation (rTMS), which consists of temporally structured magnetic pulse trains, is an emerging therapy for treatment-resistant depression [While rTMS is an effective treatment for decreasing the overall symptoms of depression, it has been found that conventional rTMS protocols over the dlPFC may not significantly treat symptoms related to anhedonia and avolition (i.e., loss of pleasure and motivation) in patients with depression [That being said, the existing rTMS protocols show high inter-individual variability in the treatment outcome and efficacy, and it is not yet understood how we might match different TMS protocols to the patients [In the present study, we evaluated the predictive value of whole-brain modeling for the therapeutic effect of applying accelerated iTBS over dmPFC for patients with depression, using a brief resting-state scan at baseline. We explored our depression sample using computational modeling to unveil covert subtypes exhibiting different whole-brain dynamics. Further, we aimed at testing if the detected subtypes differed in response to rTMS and symptom characteristics. Finding such a dichotomy further stresses the importance of stratification into treatment groups as a key step towards precision medicine.