2.2. Treatment administration
RECRUITMENT
This was the first study that directly compared the relief provided by benzydamine HCl, using 2 different formats in the same study population. Patients were randomized to treatment according to the order of recruitment either to 1 dose of benzydamine HCl spray oromucosal solution (test product - 4 nebulizations corresponding to 2.04 mg of benzydamine HCl), or to one 3 mg lozenge of benzydamine HCl (reference therapy - corresponding to 2.68 mg of benzydamine HCl), both administered at the investigational site. The efficacy evaluations started immediately after the nebulization or after the complete lozenge dissolution (taking an average time of 9.12 minutes) (Table 