Study design and patients
Study design and patient eligibility for ASCEMBL (NCT03106779) were described previously [Patients meeting lack of efficacy criteria were to permanently discontinue study treatment. A protocol amendment on December 14, 2018, allowed patients for whom bosutinib treatment failed due to lack of efficacy (based on objective laboratory criteria) the possibility to switch to asciminib. Data collected for patients receiving asciminib after switching from bosutinib are not part of this manuscript.