Discussion
PD
BRAIN
Brain dopamine may regulate sequential working memory. Dopamine deficiency in PD leads to difficulties in diverse sequencing tasks that rely on the persistent maintenance and flexible manipulation of sequential information [A single oral dose of the D2/3 receptor agonist pramipexole led to less accurate and slower responses in the digit ordering task. Also, it downregulated the dlPFC, STN, and striatal regional activity for maintaining sequences (ordered trials). In contrast, pramipexole upregulated the dlPFC and STN regional activity for manipulating sequences (random 