Introduction
cancer, Chemotherapy-induced OM, chemotherapy-induced OM
ADVERSE EFFECTS, CANCER, ORAL MUCOSITIS
Oral mucositis (OM) has been reported as one of the worst adverse effects associated with cancer therapy [Chemotherapy-induced OM usually affects the non-keratinized mucosae and is in its mildest form seen as erythematous regions with an intact epithelial lining [Several methods have been proposed for prevention of chemotherapy-induced OM [Intraoral cooling is initiated prior to the chemotherapy infusion. The cooling procedure then continues during the infusion, and for a period after the infusion has been completed. While the cooling period post-infusion depends on the half-life of the chemotherapeutic drug [The lowest achieved temperature in the oral mucosa is believed to provide the best conditions to prevent OM. Given this, it was of interest to investigate when along the course of intraoral cooling this temperature was achieved, and if there was any difference between different cooling modalities and temperatures.Thus, the aim of the present study was to study intraoral temperatures during a clinically relevant time of cooling, using IC and the ICD set to 8 or 15 °C.