Background
inflammation
SYSTEMIC DISEASE, GINGIVAL ENLARGEMENT, INFLAMMATION, SECONDARY, PERIODONTAL DISEASE
The etiology of gingival enlargement is associated with many factors including inflammation, drug use, systemic diseases, and neoplastic conditions [Management of periodontal disease must include consideration of re-establishment of the physiologic gingival architectural form. In case of gingival enlargement, the therapeutic technique to accomplish this may be done either by gingivoplasty or gingivectomy procedure [The wound site after gingivectomy and gingivoplasty operations heals by secondary intention [Photobiomodulation (PBM) is the direct application of light to stimulate cell responses in order to promote tissue healing, reduce inflammation and induce analgesia [The optimal wavelengths for PBM are in the red or near-infrared spectrum in the range of 600 to 700 nm and 780 to 1100 nm [Another factor that is expected to improve healing after surgery is the application of topical agents. Hyaluronic acid (HA), also known as hyaluronan, is one of the most recently used topical chemotherapeutic agents [It is conceivable that hyaluronan administration to periodontal wound sites could achieve comparable beneficial effects in wound healing [As per our knowledge, no study in the literature has been conducted reporting the healing outcome of surgical gingivectomy wound areas when combining both, HA gel topical application with PBMT. Based on the previously mentioned properties of HA, the aim of the current study was to evaluate the effect of topical pure 2% HA gel after PBMT on the healing of surgical gingivectomy sites.