The source of cells and administration
Allogeneic human BM-MSCs (MSV®) cultured under Good Manufacturing Practice (PEI Number 15-007) and following the method for obtaining an enriched population of functional MSCs (Patent Number PCT/EP2019/074991) were used. Cells were provided the cell processing unit of the Institute of Biology and Molecular Genetic (IBGM, R&D Building of the Miguel Delibes Campus, Valladolid, Spain) that is accredited by the Spanish Agency of Medications and Medical Devices (AEMPS) (ES/102I/22 University of Valladolid-Citospin S.L.). Cells were characterized by fluid flow cytometry following the last update of the criteria of the International Society for Celle Therapy [This investigational product is packaged in a 1-ml Luer lock syringe containing 150 µl of an isotonic medium with a cell concentration of 1.5 × 10