Acknowledgements
Grateful thanks to all of the patients who participated in this study; all involved investigators and staff at the participating centers; and the trials unit staff at the ICR-CTSU. We also thank the REASURE Trial Management Group members, past and present, and the Independent Data Monitoring Committee and Trial Steering Committee for overseeing the trial.The funders have no involvement in the study design, collection, analysis, interpretation of findings, and reporting. However, research outputs will be published in line with the funders’ publication policy requirements.