Data extraction and quality/risk of bias assessment tools
Two independent reviewers extracted the data from all the articles according to the following information: The first author, published year, location, trial registration number, study type, study phase, study population, age, sex, sample size, infusion route, intervention, control, follow-up, efficacy outcomes, safety outcomes; all data were extracted on a predefined form and supervised by the primary author. After data extraction, we assessed the methodological quality or risk of bias in RCTs through version 2 of the Cochrane risk-of-bias tool (RoB 2), where judgment can be "Low" or "High" risk of bias or can express "Some concerns." Moreover, we judge the risk of bias in non-RCTs through the ROBINS-I tool.