Endpoints
The primary objectives of the study were to establish the concordance of ctDNA molecular response with radiographic RECIST/immune RECIST (iRECIST) response and define the optimal timepoint of ctDNA molecular response. Secondary objectives included the association of ctDNA molecular response with progression-free survival (PFS) and overall survival (OS), the correlation of depth of ctDNA kinetics with radiographic response and analyses of time to ctDNA molecular response.