3.2. Ivabradine Dosage and Efficacy
bradycardia
The starting dose of ivabradine was 5 mg twice daily. The dose of ivabradine was adjusted at subsequent visits according to the heart rate and side effects. If the heart rate was >75 BPM, the dose was increased to a maximum dose of 7.5 mg twice daily. In four patients, ivabradine was increased to 7.5 mg twice a day. In three patients with heart rates > 75 BPM, the ivabradine dose was not increased due to visual side effects. No patient had to discontinue ivabradine or reduce the dose due to bradycardia. The ivabradine compliance rate was 98.6%. The heart rates achieved in ivabradine group patients are presented in In 79% of patients taking ivabradine, HR decreased by <75 BPM at the visit after two cycles of chemotherapy and remained at 75% after four cycles of anthracyclines.