Institutional Review Board Statement
The animal experiments were performed in accordance with the guidelines established by the Institutional Animal Care and Use Committee of the National Taiwan University College of Medicine. The Phase I/II clinical study was approved by the Institutional Review Board of NTUH (201710061MIPB) on 22 December 2017 and conducted according to the principles of the Declaration of Helsinki for all human experimental investigations. The Phase I/II clinical studies were registered at 