Other outcomes and subgroup analysis
SECONDARY
We conducted similar analyses to evaluate the change over time in the daily care process measures and secondary outcomes. The change over time was evaluated in predefined subgroups (low versus high baseline month compliance rates [categorized by the median of the cohort] of subglottic suctioning, SAT, and SBT, and ICUs in hospitals with >300 versus ≤300 beds), with an interaction term to assess the heterogeneity of treatment effect. The results of subgroup analyses were displayed as a forest plot. A p-value <0.05 was considered statistically significant and all analyses were performed using SAS 9.4 (SAS Institute, Cary NC).