Introduction
migraine, heterogenous diseases, Migraine
MIGRAINE, MIGRAINE, MRS
Migraine is a common, complex and debilitating neurological disorderMagnetic resonance spectroscopy (MRS) studies in migraineurs consistently show decreased ATP levels or hypometabolismSeveral nutraceuticalsOxidative stress seems to be the common denominator of most migraine triggersMetabolic approaches to migraine prevention, such as a ketogenic diet (KD), which to some extent mimics the state of fasting, have been shown to be migraine protectiveOut of the three physiologically relevant KBs β-hydroxybutyrate (BHB) constitutes up to 70%In complex and heterogenous diseases such as migraine, a therapy that can simultaneously target multiple possible pathogenic pathways seems advantageous and elevated KB levels have been shown to be well tolerated for extended periods of time, even up to several yearsOur research group wanted to examine whether exogenously raised KBs would also be able to attenuate migraine frequency, if ingested daily, and carried out the first RCT exploring the effect of BHB as a prophylactic agent in episodic migraine patients