Statistical Analysis
SECONDARY
The analysis population included patients with ambulatory BP data at baseline and all follow‐up visits. Demographics and baseline characteristics are presented using descriptive statistics, including mean±standard deviation, minimum, first quartile, median, third quartile, and maximum values for continuous variables, and frequencies and percentages for categorical variables. Between‐group differences were determined using an independent ANCOVA was used to assess treatment effects on changes from baseline to 8 weeks in 24‐hour ambulatory BP in patient subgroups based on nocturnal BP dipping status. A repeated measures ANCOVA model with treatment, postdosing hours (time elapsed since drug administration), and treatment by postdosing hour interaction as fixed‐effect factors, and mean 24‐hour ambulatory SBP/DBP at baseline and 8 weeks as repeated measures was used. In addition, between‐group differences in mean change in 24‐hour ambulatory BP from baseline to 8 weeks with 95% CIs were determined.Statistical analysis for secondary end points included 1‐way ANOVA, ANCOVA, least‐squares means with 95% CIs, and paired Statistical analyses were performed using SAS version 9.4 or higher. A 2‐sided 