4. Discussion
HIE, hypoxia, cerebral palsy, asphyxia
ASPHYXIA, INTRAUTERINE HYPOXIA, HYPOXIA, NEONATAL ASPHYXIA, CEREBRAL PALSY, COMPLICATIONS
UC-ABG analysis can determine the degree of fetal intrauterine hypoxia, which reflects the acid-base status of the fetus, and is the main method used to evaluate the fetal acid-base status and gas and substance metabolism. The neonatal central nervous system has an extremely poor tolerance to hypoxia, and central nervous system damage in asphyxiated children begins with disturbances in umbilical blood flow and fetal gas exchange. One of the most devastating complications of HIE is cerebral palsy, with children with cerebral palsy having the highest burden on families, and the effects persist throughout life. Timely and accurate diagnosis of asphyxia and correct resuscitation could reduce the incidence of asphyxia, cerebral palsy, and neonatal mortality.Our study showed that the pH, BE, and Lac values of venous blood collected using this cord blood double collection method were relatively stable. According to previous studies, pH, BE, and Lac levels are significance predictors of adverse neonatal outcomes.Some studies have suggested a negative correlation between pH and the concentrations of CD34 + cells and TNCs.Unrelated UCB donated to public banks for the common good offers substantial promise as a graft for hematopoietic stem cell transplantation, a source of different cell subsets for cellular therapies,This study had some limitations. First, the data in this study were only from the UCB collected from vaginal deliveries, and subsequent studies can further include UCB data from cesarean deliveries. There was limited data of neonates diagnosed with asphyxia in this study, and the results only showed that this method is applicable to normal neonates. Subsequent studies can be carried out on neonates diagnosed with neonatal asphyxia, but UCB collection should be based on the safety and health of neonates.In conclusion, the UCB double collection method not only meets the requirements of UCB blood gas analysis but also minimizes the impact on hematopoietic stem cell transplantation-related indices of UCB. This finding deserves attention in the field of UCB collection.