Drug administration and adverse events
non-alcoholic
ADVERSE EVENTS, HOOKWORM
The participants were asked not to take a meal for at least four hours after the drug consumption to exclude the possibility of affecting albendazole absorption by immediately taking foods. During this time, the health personnel in the health centres observed the participants to determine if any adverse events occurred. Water, and other non-caffeinated and non-alcoholic beverages were allowed during the four hours fasting period.Albendazole (AGOZOLE 400mg; batch number T11098, produced by AGOG Pharmaceutical Ltd., India) was used for the trial. AGOZOLE albendazole is approved by the National Drug Authority (NDA) of Uganda and is widely available in the Ugandan domestic pharmaceutical market (NDA registered number: NDA/MAL/HDP/3013).For those in the relevant trial arms in our study, we provided 200 grams of avocado, which contains 27–28 grams of fat [For participants in intervention groups 2 and 3, who were taking 400mg of albendazole on two consecutive days, they were asked to return to the same clinic to do so.A single stool sample was collected from each trial participant three weeks after the treatment to evaluate the albendazole efficacy while avoiding the effect of re-infection after albendazole treatment and egg production by re-infected hookworm.