Patients
toxicity
RECRUITMENT
From August 12, 2015 to March 29, 2019, a total of 18 patients underwent screening for the trial with 12 patients ultimately enrolled and treated. The trial was stopped prior to the 20 patients enrollment goal due to slow recruitment. Characteristics of the enrolled patients are listed in the Patient Characteristics section. Median age was 63.5 with a male predominance (83%). At the time of data cut-off 12 patients had completed a total of 62 cycles of treatment with the median number of cycles being 6 (range 2-9). Five of the 12 patients did not complete the initial 6 cycles of induction therapy (2 toxicity, 2 progression, and 1 early transplant after cycle 4). Only one patient proceeded to the maintenance phase of treatment and received 3 cycles of maintenance therapy before progression. Seven of the 12 patients ultimately went on to autologous stem cell transplantation.