Plasma Protein Analysis
To further evaluate the pharmacodynamic effects and potential association with clinical response to study treatment, the presence of immune and nonimmune plasma proteins was determined using a Multiplex Proximity Extension Assay by Olink Proteomics. In this assay, each biomarker is identified by a matched pair of antibodies coupled to unique, partially complementary oligonucleotides and measured by qRT-PCR, with more than 1,100 plasma analytes evaluated per sample.