Optimal, 100% sensitivity and 100% specificity diagnostic cut‐offs
Various cut‐offs were identified for SPT to EW, EW‐sIgE, OVA‐sIgE, OVM‐sIgE, BAT using CD63 and 100 ng/mL of egg extract and BAT using CD203c and 10 ng/mL of egg extract. These cut‐offs included the optimal cut‐off, positive and negative cut‐offs defined by 100% sensitivity and 100% specificity, respectively. The sensitivity, specificity, PPV, NPV, accuracy as well as number of true and false positives and true and false negatives are shown in Table Optimal, 100% sensitivity and 100% specificity cut‐offs for the various tests compared with the outcome of baked egg challenges.Abbreviations: AUC ROC, area under the receiver operator characteristic curve; BAT, basophil activation test; EW, egg white; FN, false negatives; FP, false positives; NPV, negative predictive value; PPV, positive predictive value; S, sensitivity; sIgE, specific IgE; Sp, specificity; SPT, skin prick test; TN, true negatives; TP, true positives.