Study design
hypertension, white-coat hypertension
HYPERTENSION
After signing informed consent, patients went to an eligibility visit where blood was drawn using DBS sampling and simultaneously a 24-h ABPM was started to measure blood pressure in the following 24 h. The 24-h ABPM was obliged to minimize white-coat hypertension.If daytime blood pressure measured with ABPM was at least 135 and/or 85 mmHg, patients were randomized in a 1 : 1 ratio to either a SoC arm or intervention+SoC arm using a digital randomization tool (ALEA) [SoC consisted of visits at 3 (t3), 6 (t6), and 12 (t12) months after the eligibility visit and included a blood pressure measurement, DBS sampling, and a visit to an internist or nurse specialist. All blood pressure measurements were performed as indicated in the current American and European hypertension guidelines [Directly after randomization, before any results on adherence were available, the treating physician or nurse was asked to estimate the adherence rate of included patients, to determine if there was any bias in selecting patients.