Investigational medicinal product
ADVERSE EVENTS
The active treatment is trientine, taken orally as two Cufence 200 mg hard capsules two times per day (total daily dose of trientine is 800 mg, which is equivalent to 1200 mg of trientine dihydrochloride). The comparator is placebo, manufactured to appear identical to Cufence 200 mg hard capsules, taken orally as two capsules two times per day. The treatment period is 52 weeks. IMP dose may be reduced if participants experience adverse events, with subsequent re-escalation as appropriate. The IMP is taken in addition to participants’ clinical medication regimen, which is recorded at each visit.