Background
melanoma
MELANOMA
The incidence of melanoma has rapidly increased in the past decades [Currently, early-stage melanoma is mainly treated with surgery with a good prognosis. However, before anti-Cytotoxic T-lymphocyte antigen 4 (CTLA-4) or PD-1 antibodies were available, the treatment options for advanced melanoma were limited and usually with frustrating outcomes. Among those, dacarbazine was the optimal one. The median OS was less than 1 year, and ORR was about 5% [