Pharmacokinetic assessments
In order to study the PK characteristics of FCN-159 in plasma, blood samples were collected pre-dose and 0.5, 1, 2, 3, 4, 6, and 10 h post dose on days 1 and 28 of cycle 1, and pre-dose only on days 2, 8, and 15 of cycle 1 and day 1 of cycle 2. Plasma PK parameters of FCN-159 in each dose group were analyzed with standard non-compartmental PK methods using Phoenix WinNonlin, v8.2. PK parameters included area under the curve (AUC)