Evaluation of response
cavernomas, radionecrosis
EVENTS, RECURRENCE
All patients had conventional MRI of the brain and spine within 3 weeks prior to cRIT and approximately 5 weeks after each therapy administration along with CSF collection. MRIs included sagittal and axial T1-weighted, axial T2-weighted, axial fluid-attenuated inversion recovery (FLAIR), axial diffusion weighted images, apparent diffusion coefficient and exponential maps, and postcontrast T1-weighted sequences in axial, sagittal, and coronal planes [Initial response on the first post-cRIT MRI and later recurrence on future MRIs were assessed by three board-certified radiologists per RANO/RANO-LM guidelines [Patterns of relapse (e.g., intraparenchymal and/or spine, focal or multifocal/diffuse, CSF cytology) were evaluated. Radiologic events (e.g., radionecrosis, cavernomas) were assessed.