Statistical analysis.
The sample size of 20 subjects was determined based on the expectation that data from 18 evaluable (complete) subjects would provide adequate precision estimate for the geometric mean ratios, according to the within-subject variability of TBP parameters observed in previously conducted studies conducted during fasting with a 600 mg dose with an immediate release formulation (Analyses of variance (ANOVA) was performed on the ln-transformed plasma TBP PK parameters (AUC