Study design
Danlos syndrome, orthostatic tolerance, hypermobile, hEDS
HEDS
Subjects completed a study visit at baseline and after the 3-month intervention period. During each study visit subjects completed a 10-min stand test and questionnaires to assess orthostatic tolerance and symptom severity, 24 h urine sodium, bioimpedance assessment of fluid, and a maximal exercise test. Following the baseline visit, subjects were randomized to either the exercise training (ET) or standard of care (SOC) groups using a blocked randomization scheme stratified on the basis of hypermobile Ehlers–Danlos syndrome (hEDS) diagnosis and equal randomization between groups every four subjects. Participants returned for a 12-week follow-up visit where all testing done on the baseline visit was repeated. The Mayo Clinic Institutional Review Board reviewed and approved the protocol. All participants provided written informed consent prior to study and all aspects of the study were performed in accordance with the declaration of Helsinki.