Biomarker Discriminative Accuracy Over Time
Receiver operating characteristic curve (ROC) analysis was performed to test the accuracy of serum biomarkers to discriminate between outcome groups at 24 hours, 48 hours, and 72 hours. Aβ40 indicates amyloid-β 40; Aβ42, amyloid-β 42; NfL, neurofilament light; p-tau, phosphorylated tau; t-tau, total tau.Aβ40, Aβ42, and the Aβ42/40 ratio did not significantly change between groups at 24 hours; however, a significant difference was observed at 48 hours for Aβ42 and both Aβ peptides at 72 hours. Thus, the diagnostic accuracy of Aβ remained to low at all time points (As expected, different longitudinal trajectories of p-tau in comparison to NfL and t-tau were observed in the poor neurologic outcome group (