Methylphenidate’s modulation on SN-DMN connectivity contributes to its effect on attention
attention and cognitive control, ADHD
Our last goal was to determine whether changes in functional connectivity induced by methylphenidate in the abnormal state S2 were linked to medication’s impact on sustained attention. We used IIRV from a sustained attention task as high response variability is a hallmark of inattention. We found that methylphenidate’s impact on functional connectivity between left AI and PCC in state S2 was associated with its effect on IIRV in children with ADHD. This aligns with the triple-network model of attention and cognitive control [The triple-network model suggests that the SN plays a critical role in facilitating access to attention and cognitive control resources and modulating its interaction with the FPN and DMN, which are involved in externally-oriented attention and internally-oriented mental processes. Studies in neurotypical adults have shown that attention and cognitive control modulates interaction between key nodes in the SN (e.g. AI) and DMN (e.g. PCC) [