Pretransfusion Near-Infrared Spectroscopy (NIRS) Measures by Hemoglobin (Hgb) Threshold Group
death, NDI
RESIDUAL, SECONDARY
A, Pretransfusion cerebral saturation (Csat) in the first 28 days after birth in the high– compared to low–Hgb threshold groups. B, Pretransfusion cerebral fractional tissue oxygen extraction (cFTOE) in the first 28 days after birth in the high– compared to low–Hgb threshold groups.Data on the secondary composite outcome of NDI or death were available for 97 infants (96%; 4 infants were lost to follow-up). NDI or death occurred in 36 infants (37%); 29 (30%) survived with NDI and 7 (7%) died. Predictors of NDI or death ordered by importance in the CART analysis were infant mean pretransfusion Csat 48.6% or less, mean study Hgb 12.5 g/dL or greater, and 49 or more days of mechanical ventilation prior to hospital discharge. Residual sum of squares-based importance statistic was 2.34 for pretransfusion Csat and 2.10 for Hgb. Entropy was 0.78. 