1. Introduction
inflammation, non-type, asthma, hypersecretion
INFLAMMATION, ASTHMA, ASTHMA, CHRONIC INFLAMMATORY DISEASE
Asthma is a heterogeneous and chronic inflammatory disease characterized by a spectrum of overlapping phenotypes [Neutrophils may play a key role in asthma, attracting other immune cells and contributing to mucus hypersecretion and increased smooth muscle responsiveness [It has been suggested that non-type 2 mechanisms, including neutrophilic inflammation, may directly affect patient outcomes and the efficacy of asthma treatment [Dupilumab, a fully human monoclonal antibody, blocks the shared receptor component for IL-4 and IL-13, key and central drivers of type 2-mediated inflammation [