Author contributions
JG, LS, and XW were responsible for the conception and design of the study; JG, LS, XW, ZGL, JC, YC, DMJ, LF, and LC conducted the study and collected data; QZ and PH contributed pharmacokinetic analysis; JG, LS, and XW analyzed the data and revised the manuscript; as the sponsor’s clinical research physician, PS and ZWJ participated in the protocol design, study execution, anddata analysis as well as manuscript writing and revision. All authors read and approved the final draft.