Methamphetamine
The active treatment was 0.42 mg/kg methamphetamine hydrochloride (purity 99.8 ± 1.3%). Weighted doses were rounded to the nearest whole number (e.g. weight of 74 kg × 0.42 mg = 31.08 mg, provided 30 mg). Raw product (batch numbers 14-D-12 and 19-D-01) was compounded into 5, 10 and 20 mg size #00 opaque capsules with microcrystalline cellulose filler by an independent compounding chemist. Identical matched placebo capsules comprised microcrystalline cellulose only. Methamphetamine oral fluid concentrations were measured at ~40 min and 3-h after consumption using the Quantisal Oral Fluid Collection Device (IMMUNALYSISTM).Methamphetamine analysis was carried out by Forensic Science South Australia, per the method described in 