MDASI-CML: CML symptoms and interference with daily life
rash/skin, cancers, nausea, fatigue, diarrhea, swelling, numbness, vomiting, pain, headache, dry mouth, shortness of breath
CML, CANCERS, DRY MOUTH, LACK OF APPETITE
The MDASI-CML is a validated 26-item, multi-symptom PRO questionnaire for clinical and research use. The MDASI-CML includes 13 core symptoms found to have the highest frequency and/or severity in patients with various cancers and treatment types (assessing pain, fatigue, nausea, disturbed sleep, feeling distressed, shortness of breath, problems remembering things, lack of appetite, feeling drowsy, dry mouth, feeling sad, vomiting, numbness or tingling) and 7 symptoms specific to CML (diarrhea, swelling, rash/skin change, muscle soreness/cramping, bruising/bleeding easily, malaise, and headache) [The MDASI-CML assesses the severity of symptoms at their worst in the last 24 h on a 0–10 scale, with 0 being “not present” and 10 being “as bad as you can imagine.” The symptom severity score is the mean of the 13 core symptom items and 7 CML-specific symptom items, representing overall symptom severity.The MDASI-CML also measures how much symptoms have interfered with six daily activities: general activity, mood, work, relations with others, walking, and enjoyment of life. Interference is rated on a 0–10 scale, with 0 being “did not interfere” and 10 being “interfered completely.” The symptom distress score is the mean of the six interference items, representing overall symptom distress.