3.2. Changes in Cognitive Performance
−0.21
Cognitive performance was measured using the MOCA test, the MMSE, Rey Auditory Verbal Learning Test, and verbal fluency. In all the tests, except for verbal fluency, we found some significant improvement after the intervention.The MOCA test shows a significant improvement in the IG. The variation in the IG between the baseline to the post-dose assessments is 2.81 (95% CI 1.72 to 3.90), in the CG −0.46 (−95% CI 1.70 to 0.77), which is a difference of 3.27 (95% CI 1.59 to 4.96) points (In the overall score of the MMSE test, we did not observe significant differences between the two groups. However, if we look at each of the items, we find significant differences in time orientation. The change between the baseline to the post-dose assessments in the IG was 0.01 (95% CI −0.21 to 0.23), whereas in the CG it was −0.35 (95% CI 0.60 to 0.10), which implies a difference of 0.36 (95% CI 0.02 to 0.70) points (In the Rey Auditory Verbal Learning Test (RAVLT) we observed significant differences between both groups (IG and CG) in both immediate (RAVLT-IR) and delayed (RAVLT-DR) recall. Regarding immediate recall, in the IG there is a change of 1.65 (95% CI 1.20 to 2.10) words from the baseline visit to the final visit, whereas in the CG it is 0.45 (95% CI −0.06 to 0.95). Therefore, the difference between both groups is 1.2 (0.51 to 1.89) words (