Eligibility
tumor, ophthalmopathy
CENTRAL SEROUS RETINOPATHY, TUMOR, CARDIOVASCULAR DISEASE, OPHTHALMOPATHY, DISEASE, NEUROFIBROMATOSIS TYPE 1
Full inclusion and exclusion criteria are listed in the trial protocol, located in the Patients were excluded if their tumor harbored an additional previously known or expected to be activating molecular alteration; if they had symptoms of clinical progression without radiographically recurrent or radiographically progressive disease; if they had a known or suspected diagnosis of neurofibromatosis type 1 by genetic testing or current diagnostic criteria; if they had a history or current evidence of central serous retinopathy, retinal vein occlusion or ophthalmopathy present at baseline that would be considered a risk factor for either; if they had clinically significant active cardiovascular disease; or if they were neurologically unstable despite adequate treatment.