Limitations
hypotension
Our study was limited by its sample size, and although our results show no difference in patients’ physiological parameters and postintubation hypotension after a single-dose of etomidate or ketamine, we had limited statistical power. Moreover, we did not calculate the sample size to demonstrate the differences in physiologic parameters in the design phase of the trial. However, our study has provided prospectively collected data on 28-day mortality rates that could be used for future high-quality and adequately powered studies comparing the immediate effects of etomidate and ketamine as well as mortality.