CONCLUSIONS
TXR monotherapy showed sustained decrease in ALT and body weight, but there was no substantial incremental efficacy with the combination of TXR and CVC either on ALT or body weight reduction nor in histological end points when compared with the monotherapy arms. The TANDEM study demonstrated that the safety profile of this combination therapy (TXR + CVC) was similar to that of each of the monotherapies. There were no new safety signals compared with those already reported in monotherapy studies.