2.1 Population
psychiatric, sleep disorders
Thirty healthy male volunteers aged 20–34 who had consumed cannabis for at least 1 year and held a valid driving license were recruited. The participants were divided into two groups: occasional consumers (OC) consuming 1–2 joints per week and chronic consumers (CC) consuming 1–2 joints per day. Exclusion criteria included excessive alcohol use (AUDIT score >13), usual daily intake exceeding 225 mg caffeine per day, symptoms compatible with medical, psychiatric, or sleep disorders, and consumption of drugs other than cannabis or psychoactive medication in the month prior to inclusion. Initial exclusion of consumption of other drugs relied on self-report, but this was confirmed by urine analysis using liquid chromatography coupled to mass spectrometry (psychotropic medications such as antidepressants, anxiolytics, hypnotics, and narcotic use other than cannabis i.e., opiates, cocaine, and amphetamines). Cannabis use was confirmed by urinary drug screening (using liquid chromatography and mass spectrometry) and chronic use was confirmed by capillary analysis.