Conclusions and Relevance
multiple B-cell, early-stage ERBB2/HER2-positive
BREAST CANCER
Results of this study suggest that multiple B-cell–related signatures were more strongly associated with pCR and EFS than TILs, which largely represent T cells. When both TILs and gene expression are available, the prognostic value of immune-related signatures appears to be superior.This prognostic study (in which a combined correlative analysis of the CALGB 40601 and PAMELA trials was conducted) compares the effectiveness of tumor-infiltrating lymphocytes vs immune-related gene expression signatures in predicting pathologic complete response and event-free survival in patients with early-stage ERBB2/HER2-positive breast cancer.