Repeated measures analysis of TOMAC efficacy over time
Restless Legs Syndrome
RESTLESS LEGS SYNDROME
The results above showed that TOMAC was efficacious after 24 weeks of treatment. Next, we evaluated if TOMAC was consistently efficacious over the full 24 weeks of treatment based on analysis of repeated measures at weeks 8, 16, and 24 (Results of Repeated Measures AnalysisResults of generalized linear model comparisons across the repeated measures at weeks 8, 16, and 24 compared to Week 0.Abbreviations: CGI-I, Clinical Global Impressions-Improvement; IRLS, International Restless Legs Syndrome Study Group Rating Scale; MOS-I, Medical Outcomes Study Sleep Problem Index I; MOS-II, Medical Outcomes Study Sleep Problem Index II.Efficacy results for the intervention and control groups. For each efficacy outcome measure, results are shown at weeks 0, 8, 16, 24, and 32 after entry into the extension study. Results are presented as responder rates relative to baseline for (A) CGI-I and (B) PGI-I and presented as mean scores for (C) IRLS total, (D) IRLS Question 7, (E) MOS-II, and (F) MOS-I. Treatment group data are shown in blue with triangle markers and Within the treatment group, there was also a trend towards progressively increased efficacy with longer-duration treatment from week 0 to 24 during the extension study (To further evaluate the trends towards increased response with longer-duration TOMAC, we measured the effect size from week 0 to week 24 in the treatment group based on Cohen’s d and Cohen’s 