Lung nodule malignancy
malignancy, NELSON
To address the 3rd objective, specific lung nodule features will be measured and an AI-based malignancy risk score will be computed for the lung nodules in the NELSON cohort, including baseline and new lung nodules. During the NELSON scan rounds, all CT scans were analyzed with the use of dedicated software (LungCare, version Somaris/5 VA70C-W, Siemens Medical Solutions). The analysis included semi-automated segmentation of all solid nodules, yielding quantitative imaging features such as nodule volume, diameter and average density. To complete the set of quantitative imaging features for nodules in NELSON, a novel semi-automatic algorithm for segmentation of subsolid nodules [A previously published AI-based nodule malignancy estimation algorithm [The performance of the AI-malignancy risk score will be compared to that of existing nodule risk models (Mayo Clinic model [