2.2. Simulation Scenarios
All the simulations conducted were open-loop, covering 90 days, with patients undergoing intensive insulin therapy using multiple daily injections following a basal-bolus scheme. The T1DMS automatically determined the basal rate based on the subject-specific optimal rate. The bolus insulin for each meal was calculated using Equation (1), with the ICR and ISF of each patient set as previously mentioned, the GT established at 100 mg/dL, and the IOB assumed to be negligible, as the meal plan presented in From the meal plan in The remaining experiments aimed to evaluate the effect of CC errors in patients with a propensity to CHO overestimation (i.e., EESimilarly, EAs an example, 