Power analysis
The sample size was calculated using a pilot study with 10 patients. For 1:1 parallel control, 28 patients were required in each group to obtain a statistical power of 0.90 and an α error of 0.05 for the two-sided test. Since 10% of patients might lose to follow-up and 10% might have incomplete data, this study recruited 35 patients per group, a total of 70 patients.