Data availability
The raw clinical and imaging data are protected due to patient privacy protected due to patient privacy regulations and are available from the corresponding author upon request for 10 years. Data are located in controlled access data storage at the University Hospital Heidelberg. De-identified clinical data are available upon request and only for research purposes. A first response to access requests will be provided within two weeks of written request. Sharing such data would require approval of the institutional ethics committees. De-identified data will then be transferred to the inquiring investigator over secure data file transfer. Data will then be available for six months. For the CheCUP panel design for targeted ccfDNA sequencing genome build hg19 NCBI Build 37.1/GRCh37 was used as reference. FFPE-DNA, FFPE-RNA and ccfDNA raw sequencing data were deposited into the European Genome-Phenome Archive (EGA) database under Study ID 