MRI substudy: functional connectivity analysis
Most statistically significant changes reflected higher functional connectivity after the intervention. In relation to grey matter regions associated with visual processing, significant lower functional connectivity before the intervention was found in the connection between the right lateral occipital gyrus and the right hippocampus, and between the left lingual gyrus and left lateral orbital frontal gyrus. In contrast, higher functional connectivity before the intervention was appreciated in the connection between the right lateral occipital gyrus and the right pars opercularis. Moreover, other connections with significant higher connectivity after the intervention involved the left parahippocampal gyrus, left isthmus cingulate gyrus, right insula, and right pars triangularis. These results are shown with higher detail in Fig. Connections with significant differences after therapy. Blue connections mean lower functional connectivity before than after the intervention, and orange connections mean higher functional connectivity before than after the intervention. 