2.3 TDM and mercaptopurine/placebo dose adjustments
ADVERSE EVENTS
The initial mercaptopurine or placebo dose was 25 mg/day for the first week, followed by an increase to 1–1.5 mg/kg body weight, according to the ECCO guideline.Placebo or mercaptopurine dose adjustments were also made by study physicians or unblinded clinicians based on intolerance and adverse events as well as laboratory results [