Author contributions
LSS, NJI, ABH
Trial, analysis conceived by SMC, SD, LSS, and MG (YIS assisted). ABH and YIS conducted trial operations. AOC, RM, and MG monitored trial safety. KB and HZ conducted Aβ monomer ELISA in CSF; MEH analyzed data. CMY, HME, WDG, and JRC developed, validated AβO MIE assay and conducted CSF sample measurements and analysis. KML, NJI, LW, and RY developed, validated AβO gel electrophoresis/native WB assay, and KML, NJI, LW, RY, and MEH conducted CSF sample measurements and data analysis. RJG performed the pharmacokinetic analysis. All authors interpreted data. CSD contributed to statistical analysis. SMC, KML, MEH, MG, and NJI wrote the paper. All authors read and approved the final manuscript.