Introduction
oligo-amenorrhea, endocrine disorder, PCOS, hyperandrogenism, preeclampsia
PREGNANCY-INDUCED HYPERTENSION, POLYCYSTIC OVARIES, ENDOCRINE DISORDER, POLYCYSTIC OVARY SYNDROME, HYPERANDROGENISM, PREECLAMPSIA
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women at their reproductive age. Its prevalence is 10–17% based on at least two of the three features of PCOS (oligo-amenorrhea, hyperandrogenism and polycystic ovaries) according to the Rotterdam criteria.Prokineticin-1 (PROK1) is a pleiotropic factor secreted by endocrine glands, with a broad range of biological functions. In the female reproductive system, it is expressed in the endometrium, ovaries, adrenal glands and placentaThe administration of metformin, an insulin sensitiser, in the treatment of non-pregnant PCOS women is well established.The primary objective of this study was to investigate if s-PROK1 predicts pregnancy-induced hypertension, preeclampsia and late miscarriage/preterm delivery. We hypothesised that metformin treatment was associated with lower, and hyperandrogenism with higher s-PROK1 in the second trimester.