Author contributions
MM
Contribution: KWS, KK designed the study, contributed patients, and were primarily responsible for writing of the manuscript; KWS and RB contributed equally. They had access to full trial data; PB, JS, AS, JG, DR, J.S., FF, BG, FL, SP, PS, SB, MZ, MC, SC, MM contributed patients and helped with data cleaning, and edited the manuscript; XL provided all bio-statistical support and contributed to data analysis; JB, JK contributed to the study design and contributed to the manuscript.