Statistical analyses
In the pilot study, the sample size was calculated based on the objective of assessing differences of the attainment rate of the IOC2 target because it was the primary outcome. A power analysis revealed that 69 individuals per treatment group would provide at least 90% power with a significance level of 0.05 (two-tailed) to detect a 50% relative reduction in the attainment rate of the IOC2 target. Considering a 20% loss, at least 83 patients were required in each group.Statistical analyses were performed using the R v3.0.1 software (