Association between gut microbiota, incretin response and metabolic parameters
T2D, weight loss
SEVERE OBESITY, REMISSION, STILL
A significant increase in GLP-1 and GLP-2 secretion during the MTT and LT after mRYGB was associated with changes in the microbiome.To our knowledge, no previous study has analyzed the relationship between incretin response and the gut microbiota profile after metabolic surgery in patients with severe obesity and T2D.In our cohort, a greater presence after surgery of species belonging to the families of Streptococcaceae, Akkermansiaceae, Rickenellaceae, Enterobacteriaceae, Oscillospiraceae, Veillonellaceae, Enterobacterales_uc, and Fusobacteriaceae, typically observed after massive weight loss in these patients, was associated with the improvement in the incretin (AUC for GLP-1 and GLP-2) and metabolic profile. Interestingly, species belonging to Ruminococcaceae, Erysipelotrichaceae, and Lachnospiraceae families that decreased after surgery showed an inverse association with the incretin response after an oral stimulus and with metabolic parameters. In contrast to other of their family species, Earlier studies have shown that BS induces a favorable shift into a healthier microbiome profile characterized by increased microbial richness (These modifications can be explained by several factors other than diet modifications, such as the gastrointestinal tract’s rearrangement, a relevant anatomical shift, a determinant in bile acids production, and luminal pH changes (One proposed mechanism by which gut microbiota can influence metabolic outcomes is its potential ability to modify incretin secretion, among other gastrointestinal hormones (Our data revealed that a better metabolic and incretin profile after surgery was linked to a specific gut microbiota composition. Still, the study failed to characterize a particular gut microbiota related to T2D remission, probably because it was underpowered to reach significance. Previous studies have described an increase in It is important to take into account that there are numerous interspecies and inter-gut section interactions that profiles microbial functionality.