Outcomes
death
ADVERSE EVENTS, CARDIAC EVENTS
The primary outcome was the change in C-reactive protein (CRP) from prior to intervention until day 6, or last day of hospitalization. In cases of discharge from the hospital prior to day 6, if possible, the patient was brought back for biomarker assessment 6 days after first treatment.Secondary outcomes included safety, adverse events and severe adverse events, death within 30 days, hospital length of stay, need for invasive mechanical ventilation, need for extracorporeal membrane oxygenation (ECMO), major adverse cardiac events, and change in inflammatory biomarkers, including interleukin-6, D-dimer, lactate dehydrogenase.