3. Patients enrolled in the study and sample selection procedures
multiple organ dysfunction, Coma, abdominal injuries, TBI, trauma
COMA
The current study included individuals in the emergency intensive care unit. The study staff approached the participants, assessed their eligibility, acquired informed consent, and enrolled them. The inclusion criteria were as follows: (1) individuals between the ages of 18 and 65; (2) confirmed diagnosis of severe TBI through CT or MRI within 8 hours of the trauma; (3) patients requiring immediate craniotomy as evaluated by 2 neurosurgeons; (4) randomly assigned to either receive RIPC or serve as a control group; and (5) preoperative Glasgow Coma Scale (GCS) score ranging from 5 to 8 points. The exclusion criteria included: (1) patients who were not expected to recover upon admission; (2) individuals younger than 18 or older than 65 years; (3) GCS score of 3–4 or >8; (4) pregnant women and patients; (5) those with severe cervical, chest, and abdominal injuries; (6) individuals with multiple organ dysfunction; and (7) any other explanations identified by the researchers.