MATERIALS AND METHODS
pseudophakic, corneal endothelial dysfunction
FUCHS ENDOTHELIAL CORNEAL DYSTROPHY, OPEN-ANGLE GLAUCOMA
This article is a post hoc observational analysis of surgical recordings to identify risk factors for GDs and rebubbling procedures of the prospective ADVISE trial, an international noninferiority single-blinded RCT to investigate the utility of intraoperative optical coherence tomography (iOCT) in DMEK surgery. All procedures were performed in accordance with the Declaration of Helsinki, local and national laws regarding research, European directives with respect to privacy, and 2010 CONSORT standards for reporting RCTs.Subjects underwent surgery between December 2018 and April 2021 at the University Medical Center Utrecht (n = 39), University Hospital Leuven (n = 14), or Maastricht University Medical Center (n= 14). Inclusion criteria were pseudophakic adult patients with irreversible corneal endothelial dysfunction resulting from Fuchs endothelial corneal dystrophy, eligible for DMEK surgery. Subjects were excluded if they would undergo human leukocyte antigen-matched keratoplasty, underwent previous keratoplasty, were scheduled for combined phacoemulsification procedures, and had ocular comorbidities other than ocular surface disease, stable open-angle glaucoma, and mild age-related macular degeneration/changes. Only 1 eye per subject was enrolled.Each patient underwent a comprehensive ophthalmic examination preoperatively and 1 day, 1 week, 1 month, 3 months, and 6 months after surgery. Here, we report the baseline, 3 months, and 6 months measurements in detail. The ophthalmic examination was previously reported.