2.4. Visit Programme and Material Collection
BLOOD, CLOT
Patients were asked to meet with the investigators three times over the aforementioned administration period. The baseline visit (T0) included blood collection, signing of the consent forms, and the distribution of the administration bottles. Over the course of the second meeting, conducted six weeks after the start of the study, the administration bottles were refilled, and the dosage was corrected if necessary. The administration bottles were sent to patients unable to physically attend the second meeting. During the third meeting (T1), conducted 12 weeks after the start of the study, blood was drawn again. Telephone contact was maintained with patients between the meetings.Blood was drawn into test tubes with a clot activator, then centrifuged at 2000× 