Introduction
DISEASE, ADHESION, PREMALIGNANT
Immune surveillance is a process where immune cells monitor all tissues in the body, on the alert for pathogens and premalignant and malignant cells. During this process, our immune cells travel throughout the body in a resting state, involving cell migration from the blood circulation to the tissue and returning to the blood circulation via the lymphatic system.Unique anatomical areas are smaller post-capillary veins in which the immune cells travel close to the vessel walls and recognize signals from chemokines secreted from tissue and the endothelial vessel walls [As part of the process of migrating from the blood circulation across the endothelial barrier into tissue, the immune cells sequentially engage a series of different types of adhesion molecules, including selectins and integrins, that act as both adhesive and signaling receptors [The immune system undergoes circadian cycles [Biological communication networks require a bidirectional communication from a variety of signals to function properly, and disruptions or noise in those signals can inhibit the ability to mount an appropriate immune response [This communication is disrupted by stress, disease, and environmental factors [In this process of concerted communication, the gut mucosal barrier is a pivotal area for our immune system to receive and interpret signals and communicate to the rest of the body. Macrophages and dendritic cells are embedded in the mucosal surface, and the dendritic cells extend tentacles directly into the gut lumen, sampling antigens from the gut microbiome and ingested material, including foods and pathogens present in the food [Consumption of nutraceutical products can support the natural processes of immune surveillance which represents a unique opportunity for the use of botanical extracts in preventive health. Previous research has shown that consuming certain botanical and fungal extracts can induce mild but significant changes to immune surveillance and activation status within hours [UP360, the blend tested in this study, contains two botanical ingredients and one medicinal mushroom extract. The ingredients are extracts from 