nAb titers against Omicron variants after 50 µg of mRNA-1273.222 administered as a second booster dose by prior SARS-CoV-2 infection status at prebooster.
infection
INFECTION
Prebooster and day 29 nAb titers (logLastly, binding antibody (bAb, reported as geometric mean (GM) levels) GM levels across Omicron BA.1, the ancestral SARS-CoV-2, Alpha, Beta, Gamma and Delta variants were also higher following mRNA-1273.222 than mRNA-1273 boosters, and GMRs (95% CI) ranged from 1.75 (1.57−1.96) to 2.03 (1.81−2.27) in participants with no prior infection (Supplementary Table Given the emergence of the Omicron BQ.1.1, XBB.1 and XBB.1.5 sublineages with the potential for immune escape, neutralization at day 29 against these variants was assessed in exploratory analyses for mRNA-1273.222 as described in the 