Author contributions
M.P.
J.M.-B., N.H., D.S.M., I.A., J.G.-F. and A.G. analyzed and interpreted the clinical and translational data. J.M.-B., N.H., J.M.-G., A.R., A.L.-P., J.M.T., I.S., R.D.-B. and M.P.S.-H. participated in patient enrollment and clinical data collection. D.S.M., A.C., M.P., P.R. and D.L.-L. participated in translational research experiments and patient screening. D.M. and J.F.-J. were in charge of the pathological and radiological central review. J.M.-B. wrote the manuscript. All authors have read and approved the article.