Variation across study sites
anorexia, fever
REGRESSION, ANOREXIA
The widest range of the proportion of patients reporting a specific symptom across the sites was for anorexia. A total of 97.3% (361/371) of patients in Arba Minch, Ethiopia reported anorexia between day 0 and day 13 compared with 4.7% (5/106) of patients in Krong Pa, Vietnam. The proportion of patients at the remaining sites reporting anorexia fell between these maximum and minimum values (Table Participants reporting symptoms at least once between day 0 and day 13 by study siteAfter adjusting for treatment arm, age, sex, day 0 parasite density, and day 0 fever in separate multivariable analyses for the presence of each symptom between day 0 and day 13, substantial heterogeneity remained between study sites for the covariate-adjusted estimated proportion of patients reporting a symptom (Fig. Covariate-adjusted estimate (95% CI) of proportion of patients reporting symptoms between day 0 and 13 and day 3 and 13 Legend: Covariate-adjusted site-specific estimated proportions were generated from logistic regression models adjusting for treatment arm, age, sex, day 0 parasite density and day 0 fever, with all covariates set at mean/prevalence values for all trial patients