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high-grade malignant gliomas, cancers, Glioblastoma
ADENOVIRUS, CANCERS, GLIOBLASTOMA, PRIMARY BRAIN TUMOR
Glioblastoma is the most common and lethal adult primary brain tumor. The standard of care treatment for newly diagnosed patients includes surgical resection followed by concomitant chemoradiotherapy and adjuvant temozolomideWhile immune checkpoint blockade by anti-PD1 or anti-PD-L1 antibodies have improved outcomes with objective responses in a variety of other cancers, including those in the brain such as metastatic melanomaDNX-2401 (tasadenoturev; Delta-24-RGD) is a conditionally replicative oncolytic adenovirus engineered to treat high-grade malignant gliomas