Ethical approval
This study was conducted in full accordance with the ethical principles of Declaration of Helsinki, revised in 2013 and Good Clinical Practice (GCP) Guidelines. The study protocol was independently reviewed and approved by the National Health Service (NHS) Solihull Research Ethics Committee (Reference number 21/WM/0068; IRAS Number 289334; initial approval 20/04/2021). Written informed consent was obtained from all individual participants included in the study.