Background
functional disability, Osteoarthritis, OA, arthritis, pain, peripheral sensitization
INFILTRATION, OSTEOARTHRITIS, DISEASE, ARTHRITIS, INFILTRATION
Osteoarthritis (OA) is the most common form of arthritis and a significant cause of pain, functional disability, and socioeconomic cost worldwide. OA is a disease that involves inflammatory, mechanical, and metabolic factors. All these lead to pathological changes across different weight-bearing joint tissues, severely and particularly affecting cartilage tissue [Infiltration of immune cells and release of pro-inflammatory mediators activate different inflammatory pathways in joints. These lead to the release of pro-nociceptive molecules, which induce peripheral sensitization [At the cellular level, SPMs act via specific receptors that promote macrophage phagocytosis of: pathogens, apoptotic cells, and cellular debris, that precede and is necessary for tissue regeneration. SPMs also cease infiltration of pro-inflammatory immune cells, counter-regulate pro-inflammatory mediators, and increase the production of anti-inflammatory mediators [Despite OA´s prevalence and burden, its standard treatment still involves the use of non-steroidal anti-inflammatory drugs (NSAIDs), which lack sufficient efficacy and present multiple side effects. With limited pharmacological options, in many cases joint replacement is considered as the only treatment option [In this study, the effect of consuming an SPMs enriched oil has been clinically evaluated in the context of pain in patients with OA. This randomized, double-blind, placebo-controlled trial sought to assess the efficacy of SPMs 12-week consumption in reducing pain in patients with symptomatic knee OA.