Outcomes and Mediation Modeling
Two mediation models were specified in this analysis, following previously established methods [The SF-36 model included all SF-36 domains simultaneously, and the IBDQ model included all IBDQ domains simultaneously. Initial models hypothesized that all four Mayo subscores serve as mediators on the same level. However, the data from these initial models indicated that endoscopic appearance, as determined by sigmoidoscopy, should appear causally prior to the other three Mayo subscores (online suppl. Fig. Online supplementary Figures Based on this finding, the models were respecified, and a fragment of a respecified model is shown in Figure 