Statistical analysis
EVENT
Based on previous work showing superior correlation of Median time to event for progression-free survival, overall survival and duration of response was calculated with the Kaplan–Meier method. The impact of clinical benefit on overall survival was assessed with a 24-week landmark analysis in which only patients alive after 24 weeks were considered. Additionally, a time-dependent Cox analysis was performed, with clinical benefit (on the date of first PR or at 24 weeks in cases of SD) as a time-dependent variable. Frequencies, such as response rate and clinical benefit rate, were estimated with corresponding two-sided 95% CIs (Clopper–Pearson), and comparisons between frequencies were performed using a Fisher’s exact test. Two-sided non-parametric tests were used for translational analyses, a Mann–Whitney 