Authors’ contributions
ED, OvS, and RJ initiated the research project. ED, OvS, RJ, MB, SK, FvS and AS designed the randomized controlled trial and observational cohort study protocol. AS and FvS developed and reviewed the VOC-based breath test analysis. GK and EK developed the genomic analysis. JD initiated and facilitated the collaboration between the different laboratories and uniformed laboratory analyses. SK drafted the manuscript. All authors read and revised the manuscript. All authors approved the final manuscript.