4.4. Limitations
postoperative acute pain
The disadvantage was that this protocol failed to extrapolate tolerability results including relatively unhealthy patients that underwent elective surgery through broadening the inclusion/exclusion criteria. For SAEs, more detailed documentation and analysis should be done. Further, we look forward to further studies of similar design to validate the analgesic effect of intravenous ibuprofen for postoperative acute pain to add scientific validity to the conclusions, especially with IVIB 400 mg.