The plasma concentration of acylcarnitines and amino acids.
HTN
REGRESSION, HTN
* The pairwise comparison between elevated BP group and normal BP group** The pairwise comparison between stage 1 HTN group and normal BP group.*** The pairwise comparison between stage 2 HTN group and normal BP groupAdditionally, logistic regression analysis showed that 27 acylcarnitines and 7 amino acids were more likely to increase the odds of stage 2 HTN, whereas 5 amino acids were more likely to decrease the odds of stage 2 HTN. After adjustment for age, sex, and BMI (model 1), 11 metabolites were still associated with the incident of stage 2 HTN. However, when we also adjusted metabolites for lipid profile, FPG, use of oral glucose-lowering drugs, statins, and antihypertensive drugs (model 2), C12 with OR of 1.18 (95%CI: 1.00, 1.40), C14:1 with OR of 1.20 (95%CI: 1.01, 1.42), and C14:2 with OR of 1.19 (95%CI: 1.01, 1.41) were significantly associated with an increased odds of stage 2 HTN, whereas C0 with OR of 0.75 (95%CI: 0.63, 0.90) and glycine with OR of 0.81 (95%CI: 0.68, 0.96) were associated with a decreased odds of stage 2 HTN (We also performed a factor analysis to reduce the metabolites into few factors that had maximum common variance. This technique resulted in 11 factors, the formula of which is shown in 