Contribution statement
All authors contributed to the design of the clinical study,
collection of samples and interpretation of the results. EMdH, PDC, MVH, AMN and
NMD contributed to data management and data analyses of the human study. EMdH,
PDC and MVH contributed to data collection, management and data analyses of the
mouse experiments. PDC and MVH wrote the first draft of the manuscript. All
authors reviewed and edited the first draft of the manuscript. All authors
approved the final version of the manuscript. PDC and MVH are the guarantors of
this work.