Limitations
microvascular dysfunction
DISEASE
This study has some limitations. Of note, a mechanistic study is not designed or powered to assess clinical benefit, and we only studied the effect of a single acute increase in CS pressure in patients with microvascular dysfunction. Whether similar effects occur over chronic periods and in patients with epicardial (as compared with microvascular) disease will have to be investigated. Also, the mechanisms hypothesized are based on evidence from animal models or human in vivo models of the extracardiac circulation.