Acknowledgements
The authors thank the patients and their families who made this study possible and the clinical study teams who participated in the study. The authors also thank Olga Ferrero, the primary research nurse for the study, and Esther Chan for assistance with pharmacodynamic analyses. This study was sponsored by Celgene, a Bristol Myers Squibb Company. The study sponsor was involved in the study design, analysis of data, and writing the manuscript. Medical writing and editorial assistance were provided by Bernard Kerr, PGDipSci, and Agata Shodeke, of Spark, funded by Bristol Myers Squibb.