Interventions
®, pain
INFILTRATION, INFILTRATED
Each included participant was randomized to receive infiltrations of the affected knee (3 injections on a weekly basis) with either PRGF-Endoret® (BTI) or hyaluronic acid (Euflexxa®, Copenhagen, Denmark). PRGF-Endoret® was prepared from autologous peripheral blood at each treatment visit by following subsequent steps of blood extraction, centrifugation and plasma fractioning. Plasma rich in platelets without leukocytes was then pipetted and activated with calcium chloride before infiltrated. Compliance was not considered a useful outcome to be estimated due to the fact that both interventions were administered by the researchers. Acetaminophen intake, the only permitted medication for pain relief throughout the trial period, was registered during the trial.