Randomization
The data manager, who has no contact with participants, will use the REDCap randomization module to randomly assign participants to (1) Med-A, (2) WL-A, (3) WL-Med, or (4) TDC, in a 1:1:1:1 allocation ratio. Stratified block randomization will be adopted to ensure good balance among the four study groups with respect to the selected covariates: sex, age (45–60 or 61–75 years), and baseline BMI (30–39.99 or 40–50 kg/m