Funding
TALON-1 was funded through a doctoral research fellowship from the National Institute for Health Research (NIHR) Academy (NIHR300175). The FALCON trial was funded by a NIHR Global Health Research Unit Grant (NIHR 16.136.79). The funder and sponsor had no role in study design or writing of this report. The funder has approved the submission of this report for publication. The views expressed are those of the authors and not necessarily those of the National Health Service, the NIHR or the UK Department of Health and Social Care.