Conclusion
T2DM
INSULIN RESISTANCE, INSULIN SENSITIVITY
Overall, this study has shown the potential of highly sensitive lipidomics in identifying patients at risk of developing T2DM. In addition, the lipid species identified as associated with T2DM development, combined with clinical variables, have provided a new, highly sensitive model to be used in clinical practice. The findings also suggest that the risk of T2DM development is associated with a specific lipidomic profile which is characterized by lower peripheral insulin sensitivity and higher hepatic insulin resistance. Finally, these results also indicate that we need to look closely at isomers to understand the role of this specific compound in T2DM development since isomers of the same class of lipids are associated with different outcomes.