4.1. Summary of findings
comorbid depression, RA, insomnia
MINOR
To the best of our current knowledge, this is the first sham-controlled RCT to investigate acupuncture for comorbid depression and insomnia during perimenopause, and to assess the effect in the short-, medium-, and long- term. Blinding was successful and only minor AEs were reported. The RA group reported significantly reduced PSQI scores at post-treatment and 8-week follow-up, to a greater extent than the SA group, but did not differ from the SA group on either the reduction of HAM-D