Acknowledgments
Dear Editor:We read with interest the study by Xiaoqin Li et al. that evaluated the effectiveness of probiotic supplementation on immune parameters and gut microbiota in healthy adults (a randomized controlled trial).First, as the authors described in the Study design, “Eligible participants were equally and randomly assigned into two groups using computer generated random numbers after stratification by gender and BMI (<24 or ≥24 kg/mSecond, the results of this trial suggest that synbiotic supplementation resulted in statistically significant reductions in C-reactive protein (CRP) and interferon-gamma (IFN-γ) levels at both week 4 and week 8. While describing the results as “these reductions were greater than those observed in the placebo group (A total of 106 patients were included in this article, which is a small sample study. This paper would have been improved if statistical efficiency or/and power could have been calculated. Furthermore, the interaction is an action in which two or more objects affect each other and play an essential role in this paper.Consumption per capita and average beer price.In conclusion, we thank the authors for this excellent work, which provides direct evidence for personalized supplementation of immune regulation in healthy individuals. However, we believe that the conclusions of the study would have been stronger if the previously mentioned issues had been further addressed.Our deepest gratitude goes to the authors for this excellent work, which provides important evidence.