Author contributions
MR, JP, MP
JA, FC-T and AF-M conceived the study, designed the protocol, submitted the requested changes the Institutional Board Review for its approval, organized the field work, discussed the results, and wrote the manuscript. JK helped on the trial design. AF-M recruited and randomized the patients. JZ, MP-S, LM-N, NM-R, MP, MM-F treated and followed patients. MR organized and performed the RT-PCR studies. GR organized and performed the immunological assays. JP and FC-T reviewed the microbiological and immunological data. JQ, CS, GG-A, LM-G, and JP reviewed the manuscript. CS, SM, CO, GC, JR. and GG-A coordinated and performed the 