Covariates and HF definition
death, Death
EVENTS, EVENT
Upon enrollment, the participants completed questionnaires and underwent physical examinations and laboratory measurements according to a standardized protocol, as previously described (The outcome of interest in the present analysis was incident HF, defined as the first hospitalization event for HF or death due to HF. In the ACCORD study, an independent committee adjudicated HF events as a prespecified outcome. Hospitalization for HF was based on documented clinical and radiological evidence. Death due to HF was based on clinical, radiological, or postmortem evidence of HF, with an absence of an acute ischemic event according to clinical or postmortem evidence. Time to event was calculated as the number of months until the occurrence of an HF event. Participants were censored at the time of their last follow-up.