Background
TB, TUTT
TUBERCULOSIS (TB)
I have read the journal’s policy and the authors of this manuscript report one competing interest: NAM’s institution receives funding from Pfizer which funds an unrelated observational study. Pfizer had no role in the design or conduct of this trial.¶ Membership of TUTT Trial team is provided in the Acknowledgements.The World Health Organization (WHO) recommends systematic symptom screening for tuberculosis (TB). However, TB prevalence surveys suggest that this strategy does not identify millions of TB patients, globally. Undiagnosed or delayed diagnosis of TB contribute to TB transmission and exacerbate morbidity and mortality. We conducted a cluster-randomized trial of large urban and rural primary healthcare clinics in 3 provinces of South Africa to evaluate whether a novel intervention of targeted universal testing for TB (TUTT) in high-risk groups diagnosed more patients with TB per month compared to current standard of care (SoC) symptom-directed TB testing.