Treatment conditions
The main objective of the UNITI RCT is to investigate the effects of four different interventions (SC, ST, HA, CBT) and the combinations of these interventions (CBT and HA, CBT and SC, CBT and ST, HA and SC, HA and ST, SC and ST). Internal standard operation procedures were developed, and workshop training was conducted to ensure harmonization among the participating clinical sites with regard to the procedure, technical equipment, and training of the research staff. A full description of each of the four treatments is available in the study protocol [