Subjective Effects
DRUG EFFECT
Ketanserin significantly reduced the “any drug effect” duration of LSD from an average of 8.5 hours with placebo to 3.5 hours (Parameters Characterizing the Subjective LSD Drug Effect-Time CurveAbbreviations: AUEC, area under the effect curve; LSD = lysergic acid diethylamide.*Mean Values and Statistics for the Acute Effects of LSD on the VASAbbreviations: AUEC = area under the effect curve; ΔEAcute subjective effects of lysergic acid diethylamide (LSD) over time on visual analog scales (VASs). Ketanserin reversed LSD-induced subjective effects compared with placebo. LSD was administered at t = 0 hours. Ketanserin or placebo was administered at t = 1 hour. The data are expressed as the mean ± SEM in 24 participants (12 men, 12 women). Additional subjective effects are shown in supplementary Figure 1. The corresponding maximal effect and area under the effect curve (AUEC) values and statistics are shown in Lysergic acid diethylamide (LSD) effects on 5 Dimensions of Altered States of Consciousness (5D-ASC) scale. Ketanserin administration 1 hour after LSD significantly reduced LSD-typical alterations of mind compared with placebo, indicated mainly by significantly lower three dimension (3D-OAV) and five dimension (5D-ASC) total scores. Abbreviations: AA, auditory alterations; AED, anxious ego-dissolution; OB, oceanic boundlessness; VIR, vigilance reduction; VR, visionary restructuralization. The data are expressed as the mean ± SEM percentage of maximally possible scale scores in 24 participants (12 men, 12 women). *