What this study adds
Competing interests
FRANK, URINARY TRACT INFECTIONS
A multimodal intervention including guideline information, individual prescribing feedback, and provision of regional resistance data might reduce the proportion of second line antibiotics and antibiotic prescriptions in uncomplicated urinary tract infectionsWe thank all participating practice teams, Christiane Wagner, Judith Kraft, Karin Scheeser, Mandy Böhme, and Liliana Rost for coordinating the project at the local sites; Wolfgang Schneider-Rathert for technical support of the data extraction and the members of the Advisory Board (Stanislava Dicheva-Radev, Ernst Engelmayr, Kerstin Kamm, and Florian Salm) for their project support; and members of the citizens forum for their supportive feedback. We also thank the thorough review of the article to Frank Sullivan.Extra material supplied by authorsWeb appendix: Online appendixContributors: IG, GS, AM, CH, and JB conceived the idea of the study. AG, AK, TE, AS, AME, and VM acquired data and supervised data collection in the practices. AG, AK, TE, AS, AME, and VM were involved in the statistical concept and analysis. All authors analysed and interpreted the data. IG and GS drafted the manuscript. The guarantor (IG) accepts full responsibility for the work and the conduct of the study, had access to the data, and controlled the decision to publish. The corresponding author (AG) attests that all listed authors meet authorship criteria and that no others meeting the criteria have been omitted.Funding: Funded by Innovation Fund coordinated by the Innovation Committee of the Federal Joint Committee (G-BA) in Germany (grant no. 01VSF18053). The funders had no role in considering the study design; nor in the collection, analysis, and interpretation of data, the writing of the report and in the decision to submit the article for publication; we confirm the independence of researchers from funders and that all authors, external and internal, had full access to all of the data (including statistical reports and tables) in the study and can take responsibility for the integrity of the data and the accuracy of the data analysis.Competing interests: All authors have completed the ICMJE uniform disclosure form at Patient consent: Informed consent was only obtained from the physicians; patient informed consent was not needed because only aggregated and anonymised data were collected.The lead author (the manuscript's guarantor IG) affirms that the manuscript is an honest, accurate, and transparent account of the study being reported; that no important aspects of the study have been omitted; and that any discrepancies from the study as originally planned (and, if relevant, registered) have been explained.Dissemination to participants and related patient and public communities: Study results will be presented to all participating practices and all information developed (patient information in various languages, posters, data on resistance rates) including the study homepage will be accessible to the public. Resistance rates are already included in the current update of the national guideline on urinary tract infections. The material developed will also be included in continuous medical education programmes.Provenance and peer review: Not commissioned; externally peer reviewed.