Vaccine Immunogenicity
SARS-CoV-2 infection
SARS-COV-2 INFECTION
Of the 58 patients who were successfully vaccinated, one recipient that had received JNJ-78436735 was not included for the immunogenicity analysis due to acquiring SARS-CoV-2 infection prior to the second blood draw (Post vaccination immunogenicity rates, which is the primary outcome, for BNT162b2 and JNJ-78436735 were 83.3% and 85.2% respectively (The baseline anti-spike protein SARS-CoV-2 IgG positive rate was 36.9% among all cohort and there was no statistically significant difference between BNT162b2 and JNJ-78436735. Median quantitative SARS-CoV-2 IgG titers at the time of enrollment for BNT162b2 and JNJ-78436735 were 719 (range 11–173057) AU/mL and 2385 (range 101–48296) AU/mL, respectively.Quantitative anti-spike protein SARS-CoV-2 IgG increased significantly post third dose vaccination compared to baseline (Quantitative anti-spike protein IgG titer pre and post third dose of either BNT162b2 or JNJ78436735. Each dot represents each participant’s IgG titer at pre or 1 month post third dose of vaccination.Median geometric mean titer (GMT), analyzed as the absolute fold-increase of titer from pre- to post- third dose of the vaccination, for BNT162b2 and JNJ-78436735 was 9.51 (range 0.18–284.54) and 1.64 (range 0.24–170.2), respectively and there was a trend towards BNT162b2 showing higher response (When proceeding to analyze factors affecting vaccine IgG positivity after vaccination, we found in the univariate analysis that none of the variables could be identified as risk factors since all 