2.3. Intervention
Morinaga Milk
ADVERSE REACTIONS
The test powder was composed of 50 billion cells of MCC1849 and maltodextrin derived from tapioca starch as an excipient, and the placebo powder was maltodextrin without MCC1849. Test powder and placebo powder were produced by Morinaga Milk Industry (Tokyo, Japan). The taste, smell and appearance of the test foods were confirmed to be indistinguishable before and at the end of this study by an independent investigator. Participants received test powder or placebo powder with water once daily for 24 weeks.We excluded participants who planned to be vaccinated against COVID-19, but did not prohibit vaccination during the intake period. If participants were vaccinated against COVID-19, the intake of test food was suspended for 5 days before and after vaccination. If a vaccinated participant did not suspend intake of the test food, data for the day of vaccination and the next 5 days were not used, as adverse reactions to the vaccine often occur during this time. The intake of supplements including 