Eligibility criteria criteria
GASTRIC ADENOCARCINOMA
The study will include GC patients with histologically confirmed PM scheduled for the first-line treatment if they meet all of the following inclusion criteria:
Histologically verified gastric adenocarcinoma (HER2 negative) with peritoneal metastases;Age ≥ 18;ECOG ≤ 1;Patient willing to participate;Patient is the candidate for 1st line FOLFOX palliative systemic chemotherapy.Patients will be excluded if they meet the following criteria:
Extra-abdominal metastases;Siewert I type gastroesophageal junction cancer;Mechanical bowel obstruction;Allergy to study drugs;History of previous intraperitoneal chemotherapy;Pregnancy of refusal for birth control at least 6 months post-study treatment.