Results
dyspnea, diarrhea, fatigue, appetite, constipation, pain
DISEASE, RECRUITMENT
390 patients were assessed for eligibility. Once the desired sample size was reached, recruitment efforts ended. The 78 eligible candidates were randomly allocated into intervention (n = 39) and control (n = 39). The final number of participants available for comparison of baseline and flow up data was 69. The number of participants lost to follow up was 5 in the intervention group and 4 in control group. Thus, the number of participants in the final analysis was 34 in intervention group and 35 in control group (Fig. The majority of patients in the intervention (n = 22, 67.7%) and control (n = 24, 68.6%) groups were females. There was no significant difference between two groups in terms of other demographic and disease data (p > 0.05) (Table 
General baseline characteristics of the participant’sSexN (%)Cancer typeN (%)Previous chemotherapy experienceN (%)Experience laughing yogaN (%)* Chi-square test **Exact Chi-square test ***Mann-Whitney U test ***Fisher’s exact testAt the pre-intervention stage, the mean scores of the physical function, role function, emotional function, cognitive function and social function in the intervention and control groups were not statistically significant (p > 0.05). But at at the post test the mean scores of the three functional domains such as physical functioning, role functioning and emotional functioning in the intervention group was significantly higher than that in the control group respectivly. It means that the mean scores of the physical functioning domain at the post-test in the intervention group (66.27 ± 17.59) was significantly higher than that in the control group (60.57 ± 18.81) (p < 0.05) Also mean scores of the role functioning domain in the intervention group (71.08 ± 25.06) was significantly higher than that in the control group (65 ± 76 ± 25.81) (p < 0.05). And emotional functioning domain in the intervention group (80.88 ± 16.60) was significantly higher than that in the control group (66.19 ± 26.19) (p < 0.05), (Table 
Scores of functional domains of hetalth-related quality of life*Independent-samples t-test **Mann-Whitney U test ***Wilcoxon test ****Paired-samples t-testRegarding the symptoms and single items at baseline, the mean scores of the nausea/vomiting, fatigue, pain, dyspnea, sleep, appetite, constipation, diarrhea, financial and HRQOL (overall health and quality of life) in the intervention and control groups were not statistically significant (p > 0.05) At post-test, the mean scores of fatigue and pain in the intervention group were significantly lower than the control group (p < 0.05) (Table 
Scores of symptoms and single items domains of health-related quality of life*Independent-samples t-test **Mann-Whitney U test ***Wilcoxon test ****Paired-samples t-testHRQOL means participants perspective on their overall health and quality of life