Author contributions
The authors’ responsibilities were as follows –; AMM, AS, NJC, AC, DV: designed the research; DJW, MI, RG, RK: delivered the clinical trial; AS, NJC, HS: designed the cognitive assessment strategy; CK: designed and managed the flavonoid metabolite analysis of the urine samples; MK: undertook the lipidomic analysis under the guidance of CL-Q; DJW, NJC: were responsible for MRI design and data analysis; JFP: was clinical lead on the project; DV, AS, AMM: wrote the paper, with contributions from DJW and NJC; AC, CDK, KM, CL-Q, JFP: critically reviewed the manuscript; AMM had primary responsibility for the final content; and all authors: read and approved the final version of the manuscript.