Smooth Away From Expected (SAFE) frontier
EVENT
This frontier allows for a more gradual decrease in the non-inferiority margin for decreasing control risk. While the function remains linear between 5 and 1% event risks, the decrease from 9 to 5% is quadratic, to allow a gentler and smoother reduction of the non-inferiority margin for situations where the event risk is just below 9%.We initially focus on the SAFE frontier (depicted as a black solid line in Fig. 