Introduction
postoperative pain, CPSP, pain, knee arthroplasty, TKA, chronic pain
CHRONIC POSTOPERATIVE PAIN, CHRONIC PAIN
Total knee arthroplasty (TKA) is a widely performed orthopedic surgical procedure used to address various knee joint pathologies [Chronic postoperative pain (CPSP) was defined as pain that occurred after surgery and persisted for at least 2 months. In the context of TKA, chronic pain refers to persistent pain that lasts for more than three months after the surgical procedure and proves challenging to alleviate [Therefore, the purpose of this study is to investigate the optimal dose of dexmedetomidine when combined with H-FICB for postoperative pain management after TKA. Specifically, we aim to compare the efficacy and safety of different doses of dexmedetomidine (e.g., 0.25 μg/kg, 0.5 μg/kg, and 1 μg/kg) when used in combination with H-FICB for postoperative pain management after TKA. This study has the potential to provide valuable insights into the optimal use of dexmedetomidine as an adjunct to H-FICB for postoperative pain management after TKA.