Objectives {7}
neurological deterioration, pain
ADVERSE EVENTS, COMPLICATIONS
The primary objective of this study is to evaluate the effectiveness of SBRT followed by surgical stabilization with or without decompression within 24 h compared with the standard of care, which is surgical stabilization with or without decompression followed by radiotherapy (either cRT or SBRT) as soon as the wound is healed sufficiently, in terms of physical functioning at four weeks after the start of the treatment.Secondary objectives are as follows:To compare the pain response, duration of pain relief, length of hospital stay, time to return to systemic oncological therapy including hormonal, immune, targeted, and chemotherapy, neurological deterioration, adverse events (AEs) such as wound complications, HRQOL, and survival between the intervention and control group, andTo study the cost-effectiveness to assess whether same-day SBRT and surgery is cost-effective compared with the standard of care, from a societal perspective.It is hypothesized that the same-day treatment procedure will result in faster recovery of mobility, less hospital visits, earlier pain relief from irradiation, and faster restart of systemic oncological therapy without an increase in wound complications due to the short interval between surgery and radiotherapy.