Identification of significant ligand–receptor pairs
breast tumor
BREAST TUMOR
To investigate L–R pairs mediating the CAF–M2 interaction in breast tumor tissue, we integrated both ST data and single-cell data because ST spot data contains the mixture transcriptome from a few cell types, thus cannot directly reveal the cell source of gene expression. First, we computed the Spearman correlation of ligand and receptor pairs across CAF–M2 colocalized spots. Then, we examined whether the highly correlated L–R pairs had significant co-expression between CAF and M2 across our collected scRNA-seq datasets (Supplementary Table 