Statistical analysis
We compared baseline characteristics of participants with treatment success versus those with treatment failure. Normally and non-normally distributed continuous variables were analysed using a Student’s Receiver operating characteristic (ROC) curve analysis was performed to evaluate percent in Days 1–4, 1–7, and 4–7 serum hCG change, and area under curve (AUC) for each marker was calculated alongside an optimal classification threshold, identified through maximalization of Youden’s index We included all women if they received either gefitinib or placebo in combination with methotrexate since there was evidence of ineffectiveness of gefitinib versus placebo in addition to methotrexate (A 