Dantrolene treatment decreases heart rate and improves chronotropic competency in HF/SCD
As per our experimental protocol, all groups of animals received a daily low dosage of isoproterenol bolus for 1 hr. As anticipated, the heart rate was elevated in response to β-adrenergic stimulation and recovered to resting heart rate 3–4 hr later. We assessed ECG parameters at the resting heart rate and during post β-AR stress recovery (