Introduction
deficits in social cognition, psychosis, schizophrenia, cognitive domain
People with schizophrenia frequently show deficits in social cognition, a cognitive domain comprising multiple processes including social cue perception, mentalizing, regulation of emotion and experience sharingWhile in some instances social cognition or mentalizing were shown to improve upon treatment with atypical antipsychoticsSince discovery of its psychotomimetic qualities, subanesthetic ketamine has been used as a model for psychosis in humans and rodentsThe aim of this study was to find out whether manipulating NMDA-receptor activation via ketamine would influence mentalizing and its neural correlates in healthy volunteers. We used a modified version of the Movies for the Assessment of Social Cognition (MASC) task by Dziobek and colleagues to assess the level of mentalizing (normal, over-, under- or no mentalizing)