Ethics approval and consent to participate
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. The study was approved by the local Ethics Committee of the University Hospital Hradec Kralove with favourable opinion (reference number 201705 S10P). No registration was required according to the State Institute for Drug Control of the Czech Republic, as it does not evaluate a new active substance or any new therapies.