Oral corticosteroids reduce the IMQ-driven cell infiltration in blister exudate and biopsy
blisters
INFILTRATION, INFILTRATING
In earlier skin challenge research, cellular responses were studied using invasive techniques including suction blisters and skin punch biopsies (In addition, immune cells in the blister exudate were evaluated using flow cytometry. A full overview of the analyzed immune cell subsets is shown in Oral prednisolone reduces IMQ- driven immune cell infiltration. Immune cell subsets in biopsies, quantified by IHC, showed a comparable picture to the cells analyzed by flow cytometry in blister fluid. Administration of prednisolone reduced HLA-DR and infiltrating CD11c (dendritic cells), CD4Prednisolone reduces infiltration of IMQ-driven immune cells as measured by IHC in skin punch biopsies. 