Author Contributions
RECRUITMENT
M.C.S.W., S.C.N., F.K.L.C., L.Z., J.W.Y.M., S.W. and J.Y.L.C. conceived and designed the study. M.C.S.W., J.W.Y.M., A.W., O.-L.C. and Y.-T.F. were responsible for patient recruitment and acquired clinical data. M.C.S.W., S.C.N. and F.K.L.C. analysed clinical data and interpreted the results. J.Y.L.C. and P.-K.C. executed clinical protocols. L.Z., S.W., C.K.P.M. and H.-M.T. carried out the metagenomic analysis and statistical analyses. M.C.S.W., L.Z., S.C.N., F.K.L.C. and H.-M.T. wrote the manuscript with input from all coauthors. All authors critically reviewed and approved the final version. All authors had full access to all the data in the study and accept the responsibility to submit it for publication. J.Y.L.C. and P.-K.C. monitored the data while M.C.S.W., J.H., A.W., O.-L.C. and Y.-T.F. accessed and verified the data. F.K.L.C. had final responsibility for the decision to submit for publication. F.K.L.C. and S.C.N. are the guarantors of the study. All authors have read and agreed to the published version of the manuscript.