A pre-planned targeted metabolomic cohort ancillary study was performed
Sequential Organ Failure Assessment, multi-organ failure
MULTI-ORGAN FAILURE
In brief, patients were required to have been admitted to the ICU for ≤ 24 h prior to enrolment. Included patients were those anticipated to be mechanically ventilated for > 48 h, who required enteral feeding via a nasogastric tube, had multi-organ failure (Sequential Organ Failure Assessment (SOFA) score > 2 in ≥ 2 domains at admission), had a likely ICU stay of > 7 days, and who were considered likely to survive > 10 days. The characteristics and demographics of patients randomised to each limb were well balanced.