Study population
allergic reactions
ADVERSE REACTIONS, ALLERGIC REACTION, CENTRAL NERVOUS SYSTEM DISORDERS, VITAMIN B6 DEFICIENCY, DISEASES
Patients who entered the study met all of the following criteria: men or women aged 18–75, who were patients diagnosed with Patients with any one of the following conditions were excluded: those who had used antibiotics, bismuth, or PPI during the past 2 weeks; those who had used non-steroidal anti-inflammatory drugs (NSAIDs) during the last 4 weeks; those who had used drugs that can cause vitamin B6 deficiency, such as isoniazid and antiepileptic drugs, during the past 4 weeks; those who had a history of allergic reactions to metronidazole or tetracycline; those who had clinically significant hepatic, renal, cardiovascular, respiratory, endocrine, or central nervous system disorders; those who were pregnant or nursing mothers; and those who had a history of gastrointestinal surgery.Furthermore, if the patients had any one of the following conditions, the trial would have been terminated immediately: severe adverse reactions that the patients could not tolerate during the treatment, other diseases that interfered with the outcome of the treatment, being unable to have follow-up sessions, and pregnancy during treatment.