Introduction
thrombosis, vascular damage, Vasculitis, inflammation, atherosclerotic, CVD, Behcet’s disease, hyperglycemia, metabolic disease, Behcet’s illness, endothelial cell dysfunction, atherosclerosis, platelet aggregation
CARDIOVASCULAR DISEASE, DYSFUNCTION, INSULIN RESISTANCE, THROMBOSIS, HYPERCOAGULABILITY, PLATELET DYSFUNCTION, ENDOTHELIAL DYSFUNCTION, INFLAMMATION, INFLAMMATORY DISORDER, VASCULAR PROBLEM, METABOLIC DISEASE, CHRONIC SPONTANEOUS URTICARIA, HYPERCHOLESTEROLEMIA, CAROTID ATHEROSCLEROSIS, CVD, VASCULITIS, ENDOTHELIAL DYSFUNCTION, HYPERGLYCEMIA, INFLAMMATIONS, ATHEROSCLEROSIS, CHRONIC INFLAMMATORY DISORDER
Behcet’s disease (BD) is a chronic, relapsing, inflammatory disorder characterized by systemic involvement, vascular damage, and endothelial cell dysfunction [Cardiovascular involvement ranges from 7 to 46% [Chronic inflammatory disorders are characterized by systemic inflammation that leads to cardiovascular disease (CVD) by well-established mechanisms: accelerated atherosclerosis, insulin resistance (IR), platelet dysfunction, hypercoagulability, hypercholesterolemia, and hyperglycemia [Endothelial dysfunction is a well-recognized indicator of subclinical vascular atherosclerosis; it is determined by the intima-media thickness of the common carotid artery (CIMT).Endothelial dysfunction is the first manifestation of BD’s vascular problems. It greatly contributes to the onset and progression of vascular damage in many body locations, resulting in metabolic disease consequences [Vasculitis and inflammations of the artery wall can increase platelet aggregation and inhibit fibrinolysis, resulting in thrombosis [Subclinical atherosclerosis is an early sign of atherosclerotic load, and its prompt diagnosis can postpone or prevent the development of overt cardiovascular disease [Irisin is a myokine secreted by the liver, kidney, heart, skeletal muscles, and skin in response to exercise [In 2015, Lee HJ et al. established the association between circulating irisin levels, endothelial dysfunctions, and subclinical atherosclerosis in non-diabetic adult patients by finding a substantial correlation between carotid atherosclerosis and serum irisin levels in dialysis patients [Recently Altay et al. investigated the relationship between inflammation and irisin in serum samples from chronic spontaneous urticaria (CSU) patients, they observed lower irisin levels in the CSU group, and they raised a suggestion that a decrease in irisin levels may be decisive for CSU [The purpose of this study is to determine the link between serum irisin level and subclinical atherosclerosis in patients with Behcet’s illness and to compare serum irisin to other modalities for diagnosing subclinical atherosclerosis and endothelial dysfunctions.