Funding
 This research was supported by several foundations. That included:(1) Bethune Foundation, the grant number was zllcaxw-19; (2) The Science and Technology Program of Guangzhou (202102080084, Han Yan), the Key Project of Scientific; (3) National Natural Science Foundation of China (81873277), Key Project of Jiangsu Administration of Traditional Chinese Medicine (ZD202207) and Suqian Sci&Tech Program (K20222); (4) China Postdoctoral Science Foundation (2022M723207) and the Medical Scientific Research Foundation of Zhejiang Province of China (2023KY666).