Interpretation of PRO scores—Meaningful changes
For consistency across the PRO questionnaires, and due to the lack of published data relating to minimally important difference (MID) thresholds for the CML-specific instruments (MDASI-CML and WPAI-CML), a threshold of 1.5 points or 15% is used in this analysis as a guide to clinically meaningful thresholds, in line with interpretation guidelines from certain health technology assessment (HTA) agencies [