Endpoints
TRG, tumor, locoregional failure
TUMOR, METASTASIS, SECONDARY CANCER, SECONDARY, REGRESSION, EVENTS
The primary endpoint is the 3-year DFS, which is measured from the time of randomization until locoregional failure, metastasis, secondary cancer, or all-cause mortality. The data of patients who have not experienced any events by the time of the analysis will be censored at the last follow-up date. The Kaplan-Meier method will be used to calculate the survival rates. The secondary endpoints are the pathological complete response (pCR) rate; proportions of pathologic tumor regression grade (TRG) (Dworak [