Introduction
MINST, tooth loss, Periodontitis
CHRONIC INFECTION, INFLAMMATION, PERIODONTITIS, ALVEOLAR BONE RESORPTION, PERIODONTITIS
Periodontitis is a chronic infection that leads to gingival inflammation, alveolar bone resorption, gingival attachment loss, and tooth loss.Different variations of nonsurgical periodontal therapy, such as minimally invasive nonsurgical therapy (MINST), conventional one-stage or partial quadrant scaling and root planing, and one-stage full mouth oral disinfection, demonstrate successful treatment outcomes.Proanthocyanidins (PACNs) are oligomers or polymers of monomeric flavan-3-ols produced as an end product of the flavonoid biosynthetic pathway.Collagen hydrogels are widely used as active ingredient carriers in pharmacology.To the authors’ knowledge, no clinical study has been done before to evaluate the effects of locally derived PACNs on nonsurgical therapy of periodontitis. The aim of the current clinical study was to assess the effects of collagen hydrogels with PACNs from 