Primary outcome.
Diabetic Retinopathy
DISEASE, DIABETIC RETINOPATHY
The primary outcome was the change from baseline in best-corrected visual acuity measured as Early Treatment Diabetic Retinopathy Study (ETDRS) score at week 26. The least-squares mean changes from baseline and between-group differences were adjusted for baseline value, disease phase, and the correlation between the eyes of the same patient, with the use of the generalized estimating equation. In the overall per protocol population, a more discernible difference in point estimate was observed, but the analysis was relatively less powered, leading to a wider confidence interval (difference, 6.2; 95% CI, 0.1–12.4; Supplementary Table A total of 10 sensitivity analyses that addressed assumptions on potential confounding, data missing, conservative estimate, and working correlation structures, respectively, produced largely consistent results with the primary finding, suggesting the non-inferiority for the immunosuppressant group (Supplementary Table 