1. Introduction
CVDs, death, Cardiovascular diseases, cardiovascular disease, deaths
CVD, CARDIOVASCULAR DISEASE, CARDIOVASCULAR DISEASE
Low-carbohydrate high-fat (LCHF) diets can be just as effective as high-carbohydrate, lower-fat (HCLF) diets for improving cardiovascular disease risk markers. Few studies have compared the effects of the UK HCLF dietary guidelines with an LCHF diet on lipids and lipoprotein metabolism using high-throughput NMR spectroscopy. This study aimed to explore the effect of an ad libitum 8-week LCHF diet compared to an HCLF diet on lipids and lipoprotein metabolism and CVD risk factors. For 8 weeks, Cardiovascular diseases (CVDs) are the leading cause of death, accounting for approximately 17.8 M deaths globally [One concern with LCHF diets is an increase in low-density lipoprotein cholesterol (LDL-C) compared to HCLF diets [Nuclear magnetic resonance (NMR) spectroscopy is a powerful tool that can accurately quantify lipoprotein subclasses (density, size, and particle number) and their associated lipid species [Therefore, this study aimed to investigate the impact of an ad libitum 8-week LCHF diet compared to an HCLF diet (current UK guidelines) [