Side effects
muscle cramps, pregnancy.14, constipation, hypotension, migraine
MIGRAINE, INTOLERANCE TO CARBOHYDRATE
No serious side effects have been reported during the study in the two groups. In VLCKD group, 12 patients (41.4%) reported side effects, in particular 2 patients (16.6%) reported muscle cramps, 4 patients (33.3%) weakness, 1 patient (8.3%) hypotension, 3 patients (25%) constipation and 2 patients (16.6%) unintended weight loss.4 patients (13.8%) showed poor compliance with VLCKD and decided to stop ketogenic diet referring dissatisfaction with weight-loss (25%), intolerance to carbohydrate restriction or craving for carbohydrates (25%), poor dietary variability (25%), the persistence of some residual migraine attacks despite the diet (25%). Remarkably, a relevant part of the clinical trial was performed during COVID pandemic.One patient discontinued clinical trial because she tested positive for pregnancy.14 patients (50%) of HBD group stopped clinical trial; the reasons that most frequently lead patients to reduce compliance or decide to stop with the HBD were: dissatisfaction with weight-loss (28.5%), poor time to prepare and organize meals (35.7%), changing family rituals and habits (14.3%) and lack of determination (21.4%).