Outcomes
EVENTS, SECONDARY
While the change in E/e′ assessed by echocardiography from baseline to the end of the study (48 weeks) was the primary endpoint, the secondary endpoints included the changes in (1) e′; (2) E/atrial systolic transmitral flow velocity (A); (3) deceleration time of early diastolic mitral annular velocity; (4) LV and left atrial size; NYHA functional class; (5) NT-proBNP levels; (6) serum aldosterone levels; (7) BP at each visit; and (8) the incidence of cardiovascular events. E/e′ ratio and e′ were obtained by averaging the values of septal and lateral e′. Full secondary outcomes are documented in the protocol paper