Study design
AKI
The protocol was carried out according to the principles in the Declaration of Helsinki and approved by the Yale Human Investigations Committee (HIC #2000025786) which approved a waiver of informed consent. A reliance agreement was obtained from the Bridgeport Hospital and Greenwich Hospital IRBs as well. A waiver of informed consent was granted on the basis that the intervention was minimal risk, that the rights and welfare of participants were protected, and that the study could not be feasibly conducted with consent (as the act of consent would serve to be an AKI alert of sorts). ELAIA-2 was a multicenter, parallel-group, pragmatic, open-label randomized trial of a real-time EHR alert for AKI among individuals exposed to one or more of three classes of kidney-relevant MOIs: NSAIDs; RAASi and PPIs (Supplemental Table 