Clinical outcomes
heart failure, atrial septal defect
HEART FAILURE, EVENT
Severe HF symptoms (NYHA class III/IV) at 6-months did not differ between groups. (Spontaneous closure group vs. residual shunt group NYHA III + n = 2 [33%] vs n = 9 [30%], p = 0.41).All patients completed a six-minute walk test 1-month and 6-months post-M-TEER. No significant changes in the walking distance could be observed in both groups [iASD spontaneous closure 1-month post-M-TEER vs 6-month post-M-TEER 333 (IQR 276-452) vs 397 (IQR 265-505) meter) and residual shunt group 1-month post-M-TEER vs 6-month post-M-TEER 287 (IQR 196-406) vs 284 (IQR 203-375) meter, with a Δ of 52 (IQR 29–75) vs -12 (IQR 36-40) meter] without reaching statistical significance between and within groups.Glomerular filtration rate increased significantly in both cohorts at 6-month post M-TEER compared to baseline measurements (spontaneous iASD closure group 48 (IQR 42-52) vs 62 (IQR 47-88) ml/min/mNT-proBNP levels were available for 33 patients (6 spontaneous closure group and 27 in the residual shunt group) 1-month and 6-months post-M-TEER. In trend, NT-proBNP decreased in both groups between timepoints [iASD spontaneous closure 1-month post-M-TEER vs 6 months post-M-TEER 3407 (IQR 1770-7639) vs 2679 (IQR 1616-7772) ng/ml) and residual shunt group 1-month post-M-TEER vs 6-months post-M-TEER 4108 (IQR 2395-5701) vs 3414 (IQR 1418-5362) ng/ml, with a Δ of − 326 (IQR 1996-2418) vs − 350 (IQR 987-280) ng/ml) without reaching statistical significance between or within groups.The endpoint of HF hospitalization at 6-months follow up showed no significant differences between the groups (spontaneous iASD closure vs residual shunt group 0 [0%] vs 6 [20%], p = 0.25) (Fig. Kaplan–Meier survival curves for endpoint of heart failure hospitalization at 6-month follow-up post M-TEER. Kaplan–Meier estimated event rates in the spontaneous iASD closure and the residual shunt group for the time to the endpoint of heart failure hospitalization. Abbreviations: iASD: iatrogenic atrial septal defect