Statistical analyses
SE, PVT
The statistical significance of the MWT, KSS, and PVT endpoints was evaluated using a linear mixed effect model with effects of treatment, period, sequence, and participant within sequence. The least squares (LS) mean over the four post-dose time points and associated standard error (SE) and 95% confidence intervals (CIs) for each treatment were estimated along with all pairwise differences from placebo and associated SEs, 95% CIs, and 