Dose summation
tumor, tumors
TUMOR, TUMORS
We summed dose contributions from treatment of each successive lesion until a mean dose to normal brain tissue of 3 Gy was reached. After simulating treatment to each tumor, we renormalized the dose distributions to account for the radiation that would be delivered to other tumors. Each dose distribution was weighted such that the voxel at the center of each tumor would receive the intended maximum dose. The weights were obtained by solving the following linear equation system:
where 