Circulating white blood cells
There were modest changes in the levels of circulating white blood cells, including T cells, B cells and monocytes; however, the differences between the study arms were not significant due to high individual variability.There was a small transient decrease in the absolute numbers of circulating B cells in the RO5459072 group, with a maximal reduction at week 2 [mean (A slight decrease was also seen in the absolute numbers of circulating CD8+ T cells at the end of the treatment period (week 12) in the RO5459072 group. The mean (For monocytes, there was a small increase in the absolute values over the dosing period in the RO5459072 group compared with the placebo group. The mean (