RESULTS
HIV viral suppression, viral suppression, HIV (PWH
A total of 259 people were screened for eligibility, and of these, 58 were ineligible for trial participation (55 individuals did not meet travel eligibility criteria, 1 was well-retained in care, and 2 declined to participate; Fig. CONSORT diagram of a randomized controlled trial evaluating the SEARCH patient-centered care intervention vs. standard of care among mobile persons with HIV (PWH) with or at risk for HIV viral nonsuppression in Kenya and Uganda.Characteristics of Participants Enrolled Into the Study, Overall and by ArmMissing among 8 participants (2 intervention and 6 control).Measured over prior 12 months and missing among 5 participants (3 intervention and 2 control).Over 48 weeks of follow-up, 4/201 (2%) participants died (2 in intervention and 2 in control) and 1 participant in the control arm formally transferred care out of the community. Of the remaining 196 participants, comprising the primary analytic population, end point viral loads were obtained in 94% (185/196): 96% (96/100) in intervention and 93% (89/96) in control. Viral load was not measured in 11/196 (6%) participants (4 intervention and 7 control): 9 participants were found to have moved out of the study community during physical tracing, and 2 participants could not be found, and their whereabouts were unknown.HIV viral suppression at 48 weeks did not differ significantly by trial arm with 85% viral suppression in the intervention arm vs. 86% in the control arm, for a RR of 0.99 (95% CI: 0.88 to 1.10; Proportion of participants with viral suppression (HIV RNA <400 copies/mL) by study arm at baseline and 48-week endline.Proportion of time retained in care by arm (top) and time with ART by arm (bottom), overall, by country, and among participants with baseline unsuppressed viral load (>400 c/mL) and very high mobility (>14 nights outside of community in 3 months before enrollment).Over the 48-week follow-up, all intervention participants selected at least 1 of the 7 mobility intervention options offered. Visit coverage was >98% over follow-up visits, and 90% of participants had at least 1 unscheduled visit. The choice of intervention options varied over time, with the travel pack being the most popular intervention component, followed by longer refills and out-of-clinic (“off-site”) refills (Fig. Uptake of patient-centered care intervention components as selected by participants over the 48-week study period, by study visit (ie, scheduled week postenrollment or unscheduled visit). B, Initial choice (week-0) and restocking choices for the “travel pack” intervention component of the mobile PWH-centered care intervention group participants, by study visit (ie, scheduled week postenrollment or unscheduled visit). C, Study visit site as selected by participants in the mobile PWH-centered care intervention group over the 48-week study period, by study visit (ie, scheduled week postenrollment or unscheduled visit).