Statistical analyses
SECONDARY, RECRUITMENT, EVENT
Statistical analyses were carried out using the R Environment for Statistical Computing (version 3.6.1). A sample size calculation as not performed as this was a secondary analysis of data from the EPOC study, with the number of recruited patients already determined by the EPOC study and further recruitment not possible. Further, as a secondary aim was to provide an event rate for a subsequent cluster randomized controlled trial [Patients were classified into four groups based on the type of pharmacological prophylaxis used. These groups were patients who received (1) aspirin only, (2) LMWH (dalteparin or enoxaparin) only, (3) LMWH and aspirin either concurrently or sequentially and (4) DOACs. Baseline demographic, operative and postoperative data were tabulated and compared for each prophylaxis group. ASA classification was dichotomized into whether patients had an ASA > 2 or not, the time to mobilization postoperatively into whether this occurred by the end of day 1 and duration of chemoprophylaxis into whether patients received greater than or equal to 14 days or not. The cut-off of 14 days was chosen as this represents the current minimum recommended duration of prophylaxis from the most recent international guidelines [