Limitations
T1D, AD, diabetes
TYPE 1 DIABETES, PATHOLOGY, DIABETES
This study had limitations. The major weakness of the study is the predominantly non-Hispanic White population which, while typical for type 1 diabetes in the US, limits the generalizability to other populations. Additionally, EDIC participants, who were volunteers initially enrolled in a clinical trial and subsequently in a long-term follow-up observation study, may not be representative of most individuals with T1D. However, they have been part of an observational study and been managed in the health care setting for the most of the follow-up period. Lastly, the cohort is at an age where the prevalence of AD pathology is expected to be low; this study does not address combinatorial effects of diabetes and AD pathology.