Statistical analyses
We used Stata SE version 17 (StataCorp, TX, USA) for descriptive analyses and linear mixed model analyses, and IBM SPSS version 26.0 for expectation–maximization calculation. The threshold for statistical significance was set to We dealt with any missing values in FSS-9 scores at baseline and EOT12 as “missing at random” when running expectation–maximization algorithm [The FSS-9 sum scores at baseline and EOT12 were calculated as described above (“