Associations between depression symptoms (PHQ-9) and systemic inflammation ratios at baseline.
ALI, inflammation, depressive symptoms, depression, lung cancer inflammation
ONCOLOGY, INFLAMMATION
SIR, systemic inflammation ratio; NLR, neutrophil-lymphocyte ratio; PLR, platelet lymphocyte ratio; ALI, advanced lung cancer inflammation index; CI, confidence interval; PHQ-9, Patient Health Questionnaire-9; ECOG-PS, Eastern Cooperative Oncology Group Performance Scale.Note: NLR, PLR, and ALI were log-transformed in modeling, so exponentiated estimates are provided. Estimates represent the increase in geometric mean for the corresponding SIR outcome per point increase in PHQ-9. NLR and PLR models were adjusted for ECOG-PS, race, sex, age, marital status, education level (high school or less, beyond high school) and BMI. The ALI model was adjusted for ECOG-PS, race, sex, age, marital status, education level, and treatment; BMI is used to calculate ALI, so the model was not adjusted for BMI.To illustrate significant associations at the patient level, figures display the relationship between depression [PHQ-9<8 (none/mild) vs ≥8 (moderate to severe)] and SIRs (e.g., NLR<5 vs. NLR ≥5), yielding 4 patient groups determined by cutoffs. For patients with no/mild depressive symptoms, they were as likely to be found above (50%) as they were to be below (50%) the NLR cutoff (