Statistical analyses

To examine the agreement of sample distributions with the normal distribution, graphs were used: normal QQ plot and histogram, as well as tests: Kolmogorov–Smirnov and Shapiro–Wilk.To describe important parameters, and depending on their nature, measures of descriptive statistics were used: frequencies, percentages, mean value (average), median, standard deviation (SD), and range (range).The value To test the differences between treatment groups, and depending on the nature of the examined parameters, the following were used: Fisher's exact test; Kruskal–Wallis test, Wilcoxon rank sum test.The Kaplan–Meier product‐limit method was used to display the time to maximum response, time to progression, and overall survival, and survival analysis medians and corresponding 95% confidence intervals (95% CI) were used to describe them. The log‐rank test was used to test differences in time to maximum response and time to progression.Standard tests in the statistical program R version 3.3.2 (2016‐10‐31) — “Sincere Pumpkin Patch”; Copyright (C) 2016 The R Foundation for Statistical Computing; Platform: x86_64‐w64‐mingw32/x64 (64‐bit) (Available at: 