Effects of Sirolimus on naive and memory CD4+ and CD8+ T cells subpopulations
CM
As depicted in the representative experiment shown in Figure Representative data obtained from patient n.6 showing the employed gating strategy to detect memory T cells subpopulations (naïve, CM, TM, EM, EMRA). CM, central memory; EM, effector memory; EMRA, effector memory expressing CD45RA; TM, transitional memorySummary representing the mean values of each memory T cells subset tested inside CD4+ (A) and CD8+ (B) subpopulation. (Day 0 Sirolimus, through mTOR inhibition, could increase autophagy levels,Autophagy levels of memory T cells subset tested. (Day 0 