Introduction
SCD complications, hemolysis-endothelial dysfunction, HbS polymerization-vaso-occlusion, sickle cell disease
SICKLE CELL DISEASE, PATHOGENESIS
The pathophysiological processes in sickle cell disease (SCD) are multicellular and multi-factorial [The role of inflammatory mediators is increasingly recognized in the pathogenesis of SCD complications, in concert with HbS polymerization-vaso-occlusion and hemolysis-endothelial dysfunction [With the present exploratory study, using PFT data and serum samples collected from a cohort of patients from a previous clinical trial of vitamin D therapy in children with SCD (ViDAS) [