Renal function-stratified analysis
non-low vision, NVG, renal insufficiency
REGRESSION, HYPERTENSION, RENAL INSUFFICIENCY
In the training cohort, eGFR differed significantly only in the univariate analysis between the low and non-low vision groups. We further analyzed the features and prognosis of all the patients with borderline/normal renal function (n=184), early renal insufficiency (n=43), and poor renal function (n=23). For baseline characteristics, patients with worse renal function were shown to have significantly longer symptom duration, more hypertension, lower hemoglobin levels, lower hemoglobin A1c levels, and higher fibrinogen levels (P<0.05). There was no significant difference in preoperative median BCVA measurement (normal eGFR group, 1.7 (1.0–2.0) logMAR; median eGFR group, 1.5 (1.0–2.3) logMAR; low eGFR group, 2.3 (0.8–2.3) logMAR; P=0.178). The long-term BCVA significantly improved in the three groups (P<0.01); however, those with lower eGFR experienced considerably worse vision outcomes (normal eGFR group, 0.4 (0.15–1.0) logMAR; median eGFR group, 0.7 (0.4–1.3) logMAR; low eGFR group, 0.8 (0.4–2.3) logMAR; P=0.011). Furthermore, there was no significant difference in BCVA changes among the groups (P=0.068). After adjusting for symptom duration and hypertension, renal function was still an independent predictor of negative visual outcomes in the multilinear regression analysis (P=0.024). The incidence of NVG in the renal insufficiency group (n=66) was substantially higher than that in the group of patients with borderline/normal renal function (13.6% vs. 4.9%, P=0.018). Finally, incidence of re-vitrectomy in the three groups did not differ significantly from one another (P=0.933).