Innate responses to HSV529 that differ based on prior exposure resemble differences between innate responses to yellow fever and influenza vaccinations
yellow fever
YELLOW FEVER, INFLUENZA
We analyzed the differentially expressed genes (DEGs) observed after HSV529 vaccination to investigate the transcriptomic responses which were associated with prior exposure to HSV. We compared day 1 DEGs in each of the three HSV serogroups that received HSV529 vaccine, with the early transcriptomic responses that have been previously reported in recipients of either yellow fever or influenza vaccines (Network analysis of pathways that were enriched in overlap between HSV seronegative HSV529 recipients and yellow fever vaccine recipients, showed central roles for gene sets involved in type I IFN (IFN-α/β) and antiviral innate responses (