Meaning
colorectal cancer
LIVER METASTASIS, COLORECTAL CANCER, SECONDARY
Future clinical trials of immune checkpoint inhibitors in microsatellite-stable or mismatch repair–proficient advanced colorectal cancer should stratify patients according to the presence of LM and focus on understanding the mechanism of resistance by LM.This secondary analysis of a randomized clinical trial investigates whether the presence of liver metastasis is an indicator of treatment resistance to immune checkpoint inhibitors (ICIs) in patients with advanced colorectal cancer.