Conclusion
BLOOD, RESIDUAL
This study comparing citrate vs. heparin in cell salvage in adults undergoing coronary artery bypass grafting (CABG) found significant differences in the washed red blood cell concentrates: Hb and Hct were lower in the citrate group and the washed red blood cells had a higher MCV and lower MCHC. Residual trombocyte count was higher in the citrate group. Despite these differences, WRBC concentrates in both groups met the quality guidelines published by the American Association of Blood Banks. There were no differences in the necessity for transfusion of allogenic blood products intraoperatively and postoperatively nor in coagulation parameters. Higher IL-10 was found in the citrate group in the BCR, higher myeloperoxidase (MPO) in heparin group patients after WRBC infusion a possible reflection of a proinflammatory effect of heparin compared to citrate anticoagulation.It has been speculated that intraoperative use of hemo-adsorption therapy may alleviate the hyperinflammatory response triggered by cardiopulmonary bypass during cardiac surgery, though as yet little evidence exists for a decrease in proinflammatory cytokines [