Genetic associations with change in estimated glomerular filtration rate
ΔeGFRPolymorphisms
MINOR
We first characterized associations with ΔeGFRPolymorphisms with lowest Covariates included baseline age, sex, study arm (tenofovir alafenamide fumarate or tenofovir disoproxil fumarate), and screening BMI, logMAF, minor allele frequency; SNP, single nucleotide polymorphism.Significance threshold was 0.0036 for a subset of 14 SNPs.Significance threshold was 7.9 × 10Significance threshold was 9.8 × 10Significance threshold was 8.4 × 10Significance threshold was 5 × 10Manhattan plots of genome-wide associations with change in estimated glomerular filtration rate from week 4 to week 48. The figure shows −logAs a sensitivity analysis, we repeated the above analyses but based on the change in eGFR from screening (rather than week 4) to week 48. In this analysis, no associations withstood correction for multiple testing. Inclusion of cotrimoxazole use as a covariate did not substantially alter genetic associations.