Limitations
chronic pain, pain
CHRONIC PAIN
The study has some limitations that should be considered when interpreting the results. The first limitation is that the study was conducted on healthy subjects. It is unclear if the findings can be generalizable to individuals with chronic pain in which the placebo effect may work differently. Also, the brief experimental pain we applied is different from ongoing pain. Further studies that include subjects with specific conditions are needed to test if the effects of modulating FC on the placebo effect would vary depending on the pain condition.The second limitation is that no MRI data were collected during the tDCS session on day 2. This means that we cannot know if there were any changes in FC within the DAN and FPN on day 2. It is possible that the changes in FC that were observed on day 1 were not sustained.