HBO acutely improves myocellular insulin signalling while reducing endoplasmic reticulum stress
TYPE 2 DIABETES
First, changes were analysed by comparing the difference (Δ) between pre-clamp and basal periods. During the pre-clamp period, expression of biomarkers of endoplasmic reticulum (ER) stress was measured in skeletal muscle. Expression levels of eIF2α were comparable between the interventions (ΔeIF2α, Myocellular ER stress and insulin signalling after HBO or CON in humans with type 2 diabetes. (For the clamp period, changes were analysed by comparing the difference (Δ) between clamp and basal periods. Skeletal muscle Akt was not different between the groups (ΔAkt, 