Statistical Analysis
REMISSION
The trial was designed to have a power of 80% to detect a difference of 19% between the 2 groups in the proportion of complete biochemical remission (eMethods in Analysis was conducted on an intention-to-diagnose basis: patients were analyzed in the diagnostic group to which they had been randomly assigned, and the patients with failed AVS remained in the group to which they had been randomly assigned, even though their treatment was not determined by AVS.Sensitivity analysis were conducted (1) excluding patients who were lost to follow-up, (2) excluding patients in whom the treatment decision protocol was violated (if the patient was diagnosed as having UPA but treated with medication or was diagnosed as having BPA but treated with adrenalectomy), (3) excluding patients with failed AVS or with a bilateral PAC-PCC ratio in adrenal venous blood lower than in peripheral blood, (4) excluding patients with an LI of 2 to 4, (5) increasing the AVS selectivity index from 3 to 5 in the ACTH-stimulated group and from 2 to 3 in the non–ACTH-stimulated group, and (6) decreasing the LI from 4 to 2.The extent of missing data of study variables is shown in eTable 1 in 