Participant Recruitment.
During the COSMOS enrollment process, all participants who agreed to participate in the parent trial were also mailed an invitation to enroll in the COSMOS-Web study, during the enrollment period of August 2016 to March 2018. In addition to the COSMOS inclusion criteria, the COSMOS-Web inclusion criteria required that prospective participants 1) had access to, and the ability to use, an internet-connected computer, and 2) were willing to complete the COSMOS-Web assessment annually for up to 3 y. Participants who agreed to enroll in the COSMOS-Web study were mailed instructions on how to access the study online. All participants received a $15 gift card for attempting each COSMOS-Web assessment, regardless of completion. COSMOS-Web received ethical approval from the Institutional Review Board at Brigham and Women’s Hospital/Mass General Brigham. The CONSORT diagram is presented in 