Baseline Characteristics and CIPN Score by Study Arm
disease stage, CIPN, Cancer
ADVERSE EVENTS, DISEASE, RECURRENCE, CANCER
Abbreviations: BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); CIPN, chemotherapy-induced peripheral neuropathy; GED, General Educational Development; WALC, Women’s Activity and Lifestyle Study in Connecticut; WALC-CT, Connecticut hospitals; WALC-DF, Dana-Farber Cancer Institute; WALC-G, Geisinger Health Systems; WALC-N, National.Numbers may not sum to total due to missing data, and percentages may not sum to 100% due to rounding.Race and ethnicity data were self-reported by participants.The other category comprised 4 Hispanic White, 1 non-Hispanic Black, 1 Hispanic, and 1 non-Hispanic mixed White and African American participants.Some participants were receiving maintenance chemotherapy at baseline, whereas some participants went back to chemotherapy due to disease recurrence.Overall, 34 participants were missing chemotherapy regimen data.Most participants were diagnosed at stage III or IV (78 [58.2%]), received carboplatin plus paclitaxel therapy (82 [82.0%]), and did not have disease recurrence (111 [82.8%]). Thirty-six patients (29.0%) received chemotherapy during the study because they were receiving maintenance chemotherapy or went back on chemotherapy due to disease recurrence. The mean (SD) physical activity level at baseline was 28.1 (42.4) minutes per week, and the mean (SD) self-reported body mass index (calculated as weight in kilograms divided by height in meters squared) was 29.4 (7.1). Those who did not receive chemotherapy (n = 10) had similar characteristics to those who received chemotherapy, except for disease stage (eTable 1 in Out of a possible total score of 44 on the FACT/GOG-Ntx questionnaire, the mean (SD) CIPN score at baseline was 8.4 (6.8) (exercise: 8.1 [5.6]; control: 8.8 [7.9]; By the end of the exercise intervention, 58 patients (83.8%) met 80% of the exercise goal, and according to the daily activity logs, the mean (SD) exercise time during the study was 166.0 (66.1) minutes per week. There were no adverse events or reactions reported by participants. After the intervention, the CIPN score was reduced from baseline by 1.3 (95% CI, −2.3 to −0.2) points in the exercise intervention arm, a decrease of 16%. No significant 6-month change in CIPN score was observed in the attention control arm (0.4; 95% CI, −0.8 to 1.5 points) (