4. Discussion
obesity, obese, Obesity-related metabolic disturbances, overweight, weight loss
OBESITY, OXIDATIVE STRESS, OBESE
Recent research has indicated that synbiotic interventions may be a promising approach for overweight and obesity management [The study highlights the potential benefits of a multispecies synbiotic intervention, combining probiotic bacteria (Changes in calorie intake can potentially impact alterations in waist circumference and body fat percentage among obese subjects. The findings showed that there were no significant differences in calorie intake, particularly in macronutrients, between the placebo and synbiotic groups. Therefore, decreased waist circumference and body fat percentage in the synbiotic group may not be directly attributed to changes in calorie intake. However, it is worth considering that the synbiotic intervention may have influenced the participants’ gut microbiome, leading to changes in energy metabolism and potentially promoting weight loss independent of calorie restriction.Studies have shown that modulating the gut microbiota can increase energy expenditure and reduce fat storage in overweight and obese individuals [The F/B ratio has been acknowledged to play a crucial role in maintaining intestinal homeostasis, and alterations in this ratio have been linked to various pathologies, including obesity [Obesity-related metabolic disturbances are strongly associated with an elevation in oxidative stress, which refers to an imbalance between the body’s ability to repair or neutralize the damage caused by reactive oxygen species (ROS) and their production [The present study has several strengths, including a clinical approach, an appropriate sample size for the research question, a sufficient treatment period to detect changes in antioxidant status, interventions that align with the typical daily habits of participants, and no reported side effects from the synbiotic treatment. Moreover, recruiting overweight and obese participants in this study can provide valuable insights into understanding the impact of synbiotic interventions on this population and contribute to developing more effective strategies to address obesity. The study will be relevant to a high-risk population, and the results will be more generalizable to a broader range of patients. In this study, we aim to assess the efficacy of multispecies probiotics in overweight and obese individuals. This approach differs from previous studies that have utilized multi-strain probiotics. Using multispecies probiotics confers a more diverse range of beneficial bacterial strains and promotes a more diverse gut microbiome, which may enhance gut health and overall well-being. Additionally, multispecies probiotics have the potential to provide a more comprehensive range of health benefits compared to single-strain probiotics. However, the study also has some limitations that should be acknowledged. One limitation is the lack of fecal physical examination measurements, which could have provided valuable information about the effects of synbiotic consumption on gut health. Additionally, changes in the bacterial flora were not evaluated for specific bacterial strains, which could have provided insight into the impact of the synbiotic treatment on the F/B ratio. In order to fully comprehend the impact of synbiotics on antioxidant capacity, further studies should focus on evaluating the influence of individual variations and the microbiome composition on the efficacy of treatment.