Pathway analysis
Metaboanalyst pathway analysis demonstrated differential metabolite abundance in ketogenic enteral feeding arm vs. controls in beta-alanine metabolism (Impact 0.5), glycerophospholipid metabolism (Impact 0.2) and pentose and glucoronate interconversions (Impact 0.14).Over time, changes in metabolite abundance in the ketogenic enteral feeding arm were seen in pantothenate and CoA biosynthesis (Impact 0.1) and alpha-linoleic acid metabolism (Impact 0.33). This was different to that seen in the control arm of caffeine metabolism (Impact 0.69), terpenoid backbone synthesis (Impact 0.11) and pentose and glucoronate interconversions (Impact 0.14). These data, and non-impactful pathways are summarised in Table Pathway Impact Scores following mapping of metabolites to relevant pathwaysPerformed by over representation analysis (ORA) using MetaboAnalyst. Pathway Impact scores represent an objective estimate of the importance of a given pathway relative to the global metabolic network