Study design and setting
allergic reactions
DIABETES MELLITUS, DISEASES, ALLERGIC REACTION, MALIGNANT DISEASE
The present study is a single-blind randomized clinical trial (RCT) with an allocation ratio of 1:1. The study protocol was registered in International Standard Randomized Controlled Trial Number (ISRCTN) (Registration number: ISRCTN32724024, Registration date: 22/8/2018). The study population included the patients who were referred to Razi Hospital (Rasht, Guilan province, Iran) by a Gastroenterologist for colonoscopy procedures for diagnostic indications from June 2018 up to October 2018.Patients with the following criteria were eligible for the study: (1) age was between 18 and 70 years old regardless of gender; (2) being aware of the study protocols or having an alert companion. Patients were excluded from the study if they had the following criteria: (1) showing allergic reactions to the drugs used in the study; (2) being a pregnant or lactating woman; (3) having underlying diseases that make the exercise uncomfortable for the patient, like heart, lung, malignant diseases, and diabetes mellitus; (4) having hip and knee joint replacement or any movement problems.We used random sampling (Random Allocation) using the online software to allocate participants into two intervention and control groups. All patients were randomly divided into two groups of intervention (having walking exercise) and control (without walking exercise).