Author contribution
WC and MS conceptualized the study. WC designed the study, analyzed data and wrote the first draft of manuscript. MS contributed to acquisition of data, study design and data analysis. HKR contributed to study design and data analysis. HKR, JMF, RB and CJ provided critical clinical insights into data interpretation. All authors contributed to critical revision of the paper for important intellectual content and approval of the final version to be published. WC and MS had full access to the data in the study, and take responsibility for the integrity of the data and the accuracy of the analyses.