Data analysis
Graphs and statistical analysis were performed using GraphPad Prism 6 (GraphPad Software Inc., LA Jolla, USA), SPSS (Ver. 27, IBM, Ehningen, Deutschland), MATLAB (Ver. R2022a, MathWorks Inc., USA) and Microsoft Excel (Redmond, USA). In the case of normal distribution, t-tests were obtained. If normal distribution could not be assumed, a Mann–Whitney-Wilcoxon test was applied.