Validation of the nomograms of OS and DSS
DSS
Several validation methods have demonstrated the stability and efficacy of the established nomograms. The calibration plots in the training, internal validation, and external validation cohorts for 1-, 3-, and 5-year OS and DSS were described in Calibration curves of the nomogram of CRNENs for 1, 3, and 5-year OS rates in the training cohort Calibration curves of the nomogram of CRNENs for 1, 3, and 5-year DSS rates in the training cohort ROC curves for the nomogram of CRNENs for 1, 3, and 5-year OS rates in the training cohort ROC curves of the nomogram of CRNENs for 1, 3, and 5-year DSS rates in the training cohort The DCA plots at 1-, 3-, and 5- year rates of OS and DSS in the training, internal validation, and external validation cohorts illustrated that our nomogram for CRNENs achieved positive net clinical benefits at a broad range of threshold probabilities, which indicated a high clinical utility for the nomogram model (The decision-curve analysis (DCA) plots of the nomogram of CRNENs for 1, 3, and 5-year OS rates in the training cohort 