Fluorescein staining
inferior corneal fluorescein, SE
Improvement from baseline was observed for the PL9643 group compared with the placebo group for inferior corneal fluorescein staining at week 12 (day 85, change from pre-CAE to post-CAE) with a LS mean (standard error [SE]) change of −0.92 (0.144) versus −0.38 (0.142), respectively, an LS mean treatment difference of −0.55 (0.202; nominal Difference between PL9643 and placebo at weeks 2 and 12 for the population with moderate to severe DED for corneal and conjunctival fluorescein staining In addition, PL9643 treatment demonstrated some improvement over placebo in mean change from baseline at week 12 in superior corneal and conjunctival fluorescein staining (LS mean [standard error of the mean, SEM] difference, −0.29 [0.174]; nominal 