Patient population
anorexia nervosa, weight loss, NRS, acute liver failure or cystic fibrosis
DISEASE, ACUTE PANCREATITIS, SECONDARY
The original (EFFORT) trial included all inpatients (≥ 18 years) with an expected hospital stay of more than four days, a Nutritional Risk Screening 2002 (NRS 2002) total score of 3 points or higher, and willingness to provide informed consent. The NRS 2002 is a validated tool covering nutritional status (BMI, weight loss, reduction of food intake), disease severity, and age. Exclusion criteria were: initial admission to a surgical unit or intensive care (ICU); inability to ingest nourishment orally or tolerate nutritional support at time of admission, nutritional support prior to admission, and any individuals with contraindications for nutritional support. In the original trial, other patients with certain diseases or conditions (ex. acute pancreatitis, acute liver failure or cystic fibrosis, anorexia nervosa, stem cell transplantation, terminal status, and history of gastric bypass surgery) were excluded. For this secondary analysis, we only included patients from the main study centre (Kantonsspital Aarau) where cortisol was measured as part of an ancillary project.