Funding
The study is supported by the NIHR Research for Patient Benefit Programme (RfPBP). Reference number NIHR201542.
Name and contact information for the trial sponsor: University Hospital Southampton NHS Foundation Trust (email: sponsor@uhs.nhs.uk), sponsor reference number: RHM CAN1636.The study sponsor was not involved in the study design, writing of the protocol paper or the decision to submit the paper for publication.