Machine Learning Indices, SPARE-AD and SPARE-BA, as a Function of Age
T1D, diabetes
DISEASE, DIABETES
A, there was no significant difference observed between EDIC participants (blue) and controls without diabetes (orange). In panel B, EDIC participants showed a significant increase in predicted brain age (SPARE-BA) demonstrating more advanced brain aging patterns. SPARE-AD indicates spatial pattern for recognition-Alzheimer disease; SPARE-BA, spatial pattern for recognition-brain age.To identify which brain regions have been altered due to T1D, we calculated differences in effect sizes between EDIC participants and controls across ROIs. 