Conclusions
postoperative seizures
We used RNA-seq data to propose a seven-gene signature for predicting the occurrence of postoperative seizures in patients with DHGGs. We then developed a prediction model including the identified gene-signature and clinical characteristics of the patients. Finally, we examined the potential mechanisms underlying GRE. The findings of this study may contribute to the development of personalized management strategies for patients with DHGGs and improve our understanding of the mechanisms underlying GRE in these patients. Further prospective validation of the model, ideally a randomized controlled trial of prophylactic AEDs vs no prophylaxis, in DHGGs patients with high-risk of postoperative GRE is still needed.