MR Biomarker Analysis Based on Place of Birth
MR, death, hypothermia, encephalopathy
ENCEPHALOPATHY
Of 408 neonates recruited, 114 (27.9%) died before MR imaging, and 10 parents declined consent. The remaining 284 neonates received MR imaging; of those, data from 267 (94.0%) were analyzed. Neonates who did not receive MR imaging (n = 124) had more severe encephalopathy (50 neonates [40.3%] vs 30 [10.6%]), a higher mortality rate (122 neonates [98.4%] vs 25 [8.8%]), and a higher rate of death or disability (122 neonates [98.4%] vs 70 [24.6%]) compared with those who received MR imaging (Of the 123 inborn neonates, 40 died and 1 was discharged against medical advice before the scan. The remaining 82 neonates (66.7%) received MR imaging; of those, data from 80 neonates (37 in the hypothermia group and 43 in the control group) were available for analysis. The scans were performed at a median (IQR) age of 12.0 (9.7-16.2) days in the hypothermia group and 12.0 (10.0-13.0) days in the control group.Among inborn neonates, the mean (SD) absolute levels of thalamic 