Study design and participants
critically ill
SECONDARY, CRITICALLY ILL
We conducted an exploratory secondary analysis of the EFFORT Protein trial, an international, prospective, investigator-initiated, pragmatic, registry-based, randomized, single-blinded trial, in 85 Intensive Care Units (ICUs) across 15 countries.The primary objective of this trial was to evaluate if delivering a higher, compared to usual protein dose, in mechanically ventilated critically ill patients with high nutritional risk would result in reduced TTDA. Briefly, this study enrolled adult (age ≥ 18) patients with one of the following nutrition risk factors within 96 h of ICU admission: body mass index (BMI) ≤ 25 or ≥ 35 kg/m