Statistical analysis
ICH, CRS
The sample size throughout dose escalation was based on safety considerations and following a modified 3 + 3 dose-escalation/de-escalation schema. Descriptive statistics include calculations of mean, median, standard deviation, minimum and maximum values for continuous variables and frequency distributions for categorical variables. All AEs were categorized according to the ICH MedDR codes version 23.1 and graded according to CTCAE version 5.0, except for CRS, which was graded according to the ASTCT Consensus Grading Scale. AEs were analyzed using descriptive statistics and classified by organ system and preferred term. The Kaplan–Meier method was used for PFS and OS calculations. Non-parametric tests were used throughout. Kruskal–Wallis ANOVA was used for TCR-β sequencing data and cytokine analyses. Unpaired Mann–Whitney 