Endpoints
PD, tumor, SD, death
DISEASE, TUMOR
The primary endpoints were ORR and PFS. Secondary endpoints were OS, disease control rate (DCR), duration of response (DOR), and safety. ORR was defined as the percentage of patients who had a complete response (CR) or partial response (PR). DCR was defined as the percentage of patients who had a CR, PR, or stable disease (SD). DOR was defined as the time from the first assessment of a tumor as CR or PR to PD or any-cause death. PFS was defined as the time from the date of enrollment to progression or any-cause death. OS was defined as the time from the date of enrollment to any-cause death. The date of last follow-up was recorded as censored data for survival analysis when the time of death or progression could not be confirmed or if the patient was still alive.