pCR rates by immune biomarkers
tumors, Hormone receptor-negative tumors, hormone receptor-positive tumors
DISEASE, TUMORS
PD-L1 positivity, as assessed on immune cells (IC 1, 2, or 3), was detected in 43.7% (173/396) of patient samples. Most tumors were IC 1 (26%), followed by IC 2 (14%) and IC 3 (4%). pCR rates were numerically higher in the TCH + P versus T-DM1 + P arm, regardless of PD-L1 status (Fig. pCR rates by PD-L1 status and stromal TIL level. Hormone receptor-negative tumors had a higher prevalence of PD-L1-positive status than hormone receptor-positive tumors (51.7% [78/151] vs. 38.3% [90/235]; Additional file Stromal TILs ≤ 10% and > 10% were detected in 59.5% (262/440) and 40.5% (178/440) of patient samples, respectively. pCR rates were numerically higher in the TCH + P versus T-DM1 + P arm across stromal TIL subgroups and higher in patients with stromal TILs > 10% versus ≤ 10% in both treatment arms (Fig. Results from the RNA sequencing analysis of immune markers were similar to those observed in the ITT population for all immune marker subgroups (Additional file An analysis of EFS showed long-term trends generally consistent with those obtained from the analysis of pCR, including numerically better EFS in patients with HER2 IHC3+ (vs. HER2 IHC2+), PD-L1-positive (vs. PD-L1-negative) disease, and HER2-E subtype (vs. non-HER2-E) (Additional file 