Efficacy estimates
pembrolizumab
We used Engauge Digitizer (version 12.1, Superposed graphs of the Kaplan‒Meier curves from the KYNOTE-177 trial and the estimated curves. The smooth lines indicate the fitting parametric survival models for intuitively inspecting the survival distributions. OS, overall survival; PFS, progression-free survivalThe generalized gamma model was chosen as the best fit model for the OS curve of both arms and PFS of the pembrolizumab arm, and the log-normal model was chosen for the PFS curve of the chemotherapy arm. Considerations were as follows: 1) the lowest or relatively lower AIC and BIC values among all survival models and 2) the best fit with the observed curves based on visual inspection.