Acknowledgements
This work was funded by Shionogi & Co., Ltd., Strategic Global Partnership & X (Cross)- Innovation Initiative, Graduate School of Medicine, Osaka University and Osaka University Hospital, Grant for Research and Development against Covid-19, and JSPS KAKENHI Grant Number 21K08153 (KI). The clinical study was supported by Shionogi & Co., Ltd. The quantification of lymphocytes and cytokines was supported by Strategic Global Partnership & X (Cross)-Innovation Initiative, Graduate School of Medicine, Osaka University and Osaka University Hospital, Grant for Research and Development against Covid-19. Preparation of the study report was supported by JSPS KAKENHI Grant Number 21K08153. We thank the teams in the Department of Medical Innovation, Osaka University Hospital, Yukio Tanaka for project management, Yasue Imagawa for data management, Takashi Hirota for programming, Sayuri Tsurumura and Miho Tarui for study monitoring, Manabu Yamaji, Megumi Asayama, and Tsubasa Nagata for drafting the protocol, Etsushi Iida, Mayuko Ouchi, and Yoshiaki Yamagishi for drafting a clinical study report, and Yukiko Shiromoto and Keisuke Sawada for the study audit.