IRS combined with single-cell analysis identifies communication perturbations in high-risk cells
cancer, tumor, tumors
CANCER, TUMOR, TUMORS, DISEASE PROGRESSION
Cell-to-cell communication plays a crucial role in understanding the complexity of the tumor immune microenvironment. For instance, in cancer, tumor cells interact with various immune cells and stromal cells in the tumor microenvironment. These interactions can shape disease progression and response to therapy. However, this is not captured by bulk transcriptomic data. Luckily, single-cell sequencing technology enables the possibility of uncovering intricate and complex interactions between cells. Single-cell analysis of tumors and immune cells can provide an in-depth understanding of the molecular mechanisms of tumor-immune cell interactions, which can offer information for the development of new immunotherapies. Hence, we acquired and processed single-cell sequencing data from the tumor sites of three patients with GC.Here, a total of 10,234 cells passed quality control. All cells were annotated according to cell surface markers (Fig. Single-cell analysis of IRS. (