Medical group
After 4 weeks of spironolactone/eplerenone, further treatment titrations in the medical group were at the discretion of the study or referring physician. Formal study visits occurred at 9–12 months and 24 months, where the same clinical and biochemical measurements as at the baseline visit were performed, except BNP, troponin and 24-h urine measurements, which were repeated only once, at the 9- to 12-month visit.