Conclusion
suicidality, depression
INFLAMMATION
In conclusion, KP appears to play a role in increase suicidality in patients with depression and is associated with increased inflammation. Targeting KP in these individuals (especially those unresponsive to standard treatment) could be a potential personalized approach. Although minocycline appears to reduce suicidality in this population, further studies are needed to understand whether KP may be or not the mediating mechanism of this effect.