Conclusions
constipation
ADVANCED CANCER
L‐TAMS outperforms a placebo in enhancing the analgesic effect of opioids and reducing the necessary opioid dosage. Moreover, L‐TAMS can significantly relieve opioid‐induced constipation. These advantages may be beneficial to patients with advanced cancer.A randomized, double‐blind placebo‐controlled prospective clinical trial. Oral magnesium‐L‐threonate enhances the analgesia and reduces the dosage of opioids needed in advanced cancer patients. Magnesium‐L‐threonate inhibits or eases morphine tolerance. Magnesium‐L‐threonate relieves opioid‐induced constipation
Siyin Wu and Tian Jin contributed equally to this article.