Enhancement of compliance of patients
CRF
CRF

Researchers will conduct informed consent carefully to ensure subjects understand experimental requirements fully and comply to trial. They should know that the sponsor will provide free trial medication, laboratory examination fees and so on.Using dose counting method monitors subjects compliance. Compliance = actual dosage/prescribed dosage × 100%. Good drug compliance: 80 − 120%; poor drug compliance: less than 80% or more than 120%.Researcher should require subjects to bring all drugs when follow-up and record on CRF. Patients with poor efficacy and compliance will strengthen follow-up.