Organ function parameters and cognitive function
SE, organ damage, cognitive impairment
In the PP population, 14 of 15 (93.3%) participants experienced normalization of all three organ damage maker levels, with the median time to normalization in these individuals occurring at 2.65 (95% CI: 0.98–4.98) days (Fig. Kaplan–Meier plot of time to normalization of all three markers of organ damage (lactate dehydrogenase, cardiac troponin I, and serum creatinine) in the per-protocol population. The x indicates a censored eventMean (range) SMMSE scores improved steadily over the course of treatment in the PP population, from 17.7 (0–30) at baseline (i.e., moderate cognitive impairment) to 25.5 (0–30) on day 5, 27.9 (16–30) at Week 1 (i.e., mild cognitive impairment), 29.6 (27–30) at Week 5 (i.e., normal cognition), and 29.9 (29–30) at the final follow-up visit. Mean (SE) SMMSE scores are shown in Fig. Mean (standard error) standardized Mini-Mental State Examination scores in the per-protocol population. 