Introduction
inflammation, nerve injury, arthritis, pain
INFLAMMATION, ARTHRITIS
[version 1; peer review: 2 approved]

 The aim of this study was to determine the clinical effectiveness and safety profile of PeaNoc XL in patients with arthritis experiencing joint pain and inflammation.



Alternative medicine, encompassing herbal medicines, phytonutrients, ayurvedic products, and nutraceuticals, is commonly employed by a substantial number of patients worldwide to address diverse health conditions. According to available data, approximately 80% of the global population relies on herbal products as their primary choice of treatment for various ailments. The utilization of alternative medicines, including classical herbal products, has exhibited a consistent and notable upward trend over the past few decades.
PeaNoc XL Tablet is extensively utilized for the purpose of pain and inflammation management. PeaNoc XL Tablet is a combination of palmitoylethanolamide 400mg and astaxanthin 1mg.Palmitoylethanolamide (PEA) is an endogenous fatty acid amide belonging to the class of lipid mediators and the family of N-acylethanolamines (NAEs). It shares similarities with the endocannabinoid anandamide (AEA). PEA demonstrates inhibitory effects on the release of pro-inflammatory mediators from activated mast cells and diminishes mast cell activation at nerve injury sites.
Astaxanthin is a carotenoid primarily present in natural sources and marine organisms, including microalgae, salmon, trout, krill, shrimp, crayfish, and crustaceans.
To the best of our knowledge, there is no scientific study investigating the efficacy and safety of PeaNoc XL in arthritis patients. Therefore, a clinical trial was conducted to assess the clinical efficacy and safety of PeaNoc XL specifically in arthritis patients experiencing joint pain and inflammation.