Biomarkers for SOS risk.
Levels of 3 biomarkers (L-ficolin, HA, and ST2) previously identified in a proteomic study (We next calculated the AUCs of the ROCs on day 3 and day 7 after HCT for each marker (Optimal cutpoints were determined by exhaustive grid search and Youden’s index based on a previous retrospective study. The retrospective study included biomarker data from 3 cohorts of matched cases (For clinical applicability, biomarkers were then dichotomized into high- and low-risk groups based on cutpoints determined above. Cumulative incidence curves of SOS stratified by day 3 biomarkers were generated individually. Low levels of L-ficolin (<1100 ng/mL) and high levels of HA (>200 ng/mL) and ST2 (>45 ng/mL) were associated with a greater cumulative incidence of SOS. As compared with patients with high L-ficolin values, patients with low L-ficolin values were 9.1 times as likely to develop SOS (95% CI 2.6–32.4, 