Association of TILs and iGESs With EFS in the CALGB 40601 Trial
REGRESSION
In the CALGB 40601 trial, 37 iGESs, but not TILs, were significantly associated with EFS in Cox regression models adjusted by treatment group (eTable 6 in the Finally, we wanted to test whether the combination of iGESs and TILs was more prognostic than each alone by comparing multiple multivariable Cox regression models. To test this, we selected 6 immune signatures that outperformed TILs for pCR and were also prognostic in the CALGB 40601 trial: 3 IgG signatures, 2 B-cell signatures, and 1 plasma cell signature. The results for 1 of the IgG signatures are shown in 