Statistical analysis
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The primary PK parameters (CThe pharmacokinetic (PK) analyses were performed by Nuventra Pharma Sciences, Inc. located in Durham, NC. PK parameters were derived from the baseline-adjusted plasma nicotine concentrations-time data by noncompartmental methods using Phoenix® WinNonlin® (Version 6.3; Certara USA Inc., Princeton, NJ).
AUCs were calculated using the linear trapezoidal rule. C