Criteria for discontinuing or modifying allocated interventions {11b}
If it turns out that patients do not meet the inclusion criteria after randomization (e.g., proper planning of the radiation dose is not possible without meeting the constraints to the organs at risk, especially the spinal cord), patients will be excluded from the BLEND RCT and they will receive standard of care. The intervention or standard of care can be discontinued or modified for urgent medical reasons. Patients can withdraw consent for the intervention and/or participation in the PRESENT cohort (and hence the BLEND RCT) at any time for any reason if they wish to do so without any consequences.