Conclusions
TEEs, tumor, cancer
CANCER, TUMOR
Despite promising preclinical results and observed peripheral target engagement at higher doses, the incidence of TEEs, variable target engagement at the tumor level, and observed limited clinical efficacy led to early termination of this trial. It is not known whether the lack of clinical efficacy and elevated risk of TEEs is specific to GSK3368715 or if type I PRMT inhibition may still be a viable cancer treatment alone or in combination with other therapies. No future clinical trials are planned at this time for GSK3368715 and it would be important that further development of drugs in the same class will require an understanding of the mechanism by which inhibition of type I PRMTs may impact the risk for TEEs.