Exercise tests
ST-segment depression
The three 45 min exercise tests were performed consistently across all treatment groups regarding heart rate (CON 144 ± 3, D40 145 ± 3, D20-P 144 ± 3 beats per minute). All participants cycled at 70% of their heart rate reserve, except for one participant, who cycled all three tests at 57% heart rate reserve because of mild ST-segment depression during CPET. The increase in blood lactate (Δ lactate CON 0.76 ± 0.15, D40 0.97 ± 0.35, D20-P 0.69 ± 0.14 mmol/l) and decrease in blood glucose levels (Δ glucose CON −3.88 ± 0.95, D40 −4.91 ± 0.50, D20-P −3.69 ± 0.58 mmol/l) during cycling did not differ for the three exercise tests (ESM Fig. 