Results
PAPILLARY THYROID CARCINOMA
This study included a total of 189 patients who underwent elective thyroidectomy for papillary thyroid carcinoma. Patients were randomly assigned to three different doses of rocuronium test groups: ROC1 group (0.3mg/kg, n=63), ROC2 group (0.6mg/kg, n=63), and ROC3 group (0.9mg/kg, n=63). The flow chart is shown in The flow diagram of patient selection in our study.Demographic and perioperative characteristics.ROC1 group: 1x ED95 rocuronium (0.3mg/kg); ROC2 group: 2x ED95 rocuronium (0.6mg/kg); ROC3 group: 3x ED95 rocuronium (0.9mg/kg); BMI, body mass index; F, female; M, male; Data are expressed as There is no significant difference in IONM evoked potential among the three patient groups, but there is a significant difference at each time point. The IONM evoked potential is not the same at different time points, and the rate of change at different times in different groups is not the same. The pairwise comparison shows that the relationship between different times is R120>R110>R100>R90>R1 (IONM evoked potential.Unit: μV. The data are expressed as The uppercase letter 'F' represents the F-value or F-statistic.The Profile plot of IONM evoked potential at each monitoring time for three groups of patients.In summary, there is no statistically significant difference in VHI-30 scores among the three patient groups. However, there is a statistically significant difference in VHI-30 scores at each time point, and there is no interaction between group and time. This means that the VHI-30 scores are the same at different time points and that the rate of change at different times in different groups is also the same. By comparing pairs, it can be seen that the relationship between different times is postoperative day 1 > postoperative day 10 > postoperative 2 months, and there is no statistically significant difference among the groups (VHI scores.The data are expressed as x ®±SD, and all p-values are obtained by repeated measurement variance analysis. a represents the within-group (time) effect, b represents the between-group (group) effect, and c represents the group × time effect.The uppercase letter 'F' represents the F-value or F-statistic.The statistical analysis revealed significant differences in SBP, DBP, and HR among the three groups at different time points. SBP exhibited a cross-effect between group and time, whereas DBP and HR had consistent rates of change at different time points. There was no significant difference in Ta, Tb, Tc, and Td time points between groups (all p>0.05) (For specific data, please refer to the supplementary materials). The results of Cooper scores and intraoperative body movements of the three groups of patients showed that all patients had successful tracheal intubation once. Compared with the ROC1 group, the intubation conditions of the ROC2 group and ROC3 group were better, and the difference was statistically significant (both p<0.001). Compared with the ROC1 group, the number of patients with intraoperative body movements in the ROC2 group and ROC3 group was less (both p<0.001), and there was no statistically significant difference between the ROC2 group and ROC3 group (p=0.285) (COOPER score and intraoperative body movement.*p-value is obtained by rank sum test, and there was no significant difference between groups with the same letter subscript. **p-value was obtained by chi-square test, and there was no significant difference between groups with the same letter superscripted.