Outcome measurement techniques
PCD
LYMPHEDEMA
This study assessed the CV and responsiveness to change of a wide range of measurements used in previous lymphedema studies. Perometry and BIS measured both single-treatment effects and those over the 5 days of the study. While tonometry,PROs are also recommended but given the CVs found here, it is suggested that they are limited to LYMQOL, to reduce the burden on participants for completing questionnaires.This preliminary study succeeded in defining a feasible framework for a future definitive trial of PCD dosing. Strengths of this study include the broad set of measurements assessed and the comparison of short- and medium-term effects. Limitations include the difficulty in recruiting participants which led to a failure to recruit the planned number; a study population unrepresentative of real-world clinical practice; and the lack of a control group of “no treatment” (as the use of PCDs was considered an established treatment).