Ethics approval and consent to participate
The study has been approved by the Ethics Committee of the Fourth Affiliated Hospital Zhejiang University School of Medicine (approval number: 202–031), and was registered with the Clinical Trial Registry in the 01/02/2021(No: ChiCTR2100042954). Written informed consent was obtained from patients and their families prior to data collection or study intervention. This study adhered to the CONSORT guidelines, and all methods were performed in accordance with the relevant guidelines and regulations (for example- Declarations of Helsinki).