Conclusion
chronic pain, endometriosis-associated pain, pain
ADVERSE EFFECTS, CHRONIC PAIN
Our study could not show that 20 mg of melatonin given orally at bedtime during two menstrual cycles/ two months had better analgesic effect on endometriosis-associated pain as compared with placebo. We studied a higher dose melatonin than previously studied for EAPP, however no major adverse effects were observed. The mean levels of pain in our study might have been too low to detect any effect compared with placebo. Further studies with larger study populations may be of use to this group of patients suffering from chronic pain and limited treatment options.