Data collection and masking
Cataracts, stroke
CATARACTS, EYE DISEASE, STROKE, HEART ATTACK
Measurement of BCVA was performed with ETDRS charts using standardized procedures. Cataracts were graded using Age-Related Eye Disease Study photographic standards. CMT was measured from the central 1 mm subfield from spectral domain OCT (Cirrus; Zeiss). Wide-field fundus imaging and FFA was performed (Optos®). Patients underwent dilated fundal examination at each visit. Wide-field FFA was performed at baseline and the Exit visit. At each visit, patients were asked about stroke or heart attack since their last visit. If a patient withdrew their consent, an early exit visit was conducted where possible. When the interval between injections was greater than 3 months, an additional safety visit was arranged. Source data were verified by an independent study monitor of all BCVA and OCT data for all patients.