Background
AIDS, toxicity, Human immunodeficiency virus (HIV), retinal toxicity, multisystem disease, CMVR
ACQUIRED IMMUNE DEFICIENCY SYNDROME, AIDS
Human immunodeficiency virus (HIV) is a retrovirus that replicates in CD4 T lymphocytes and causes a multisystem disease called acquired immune deficiency syndrome (AIDS) [Ganciclovir has been approved for administration via two routes to treat CMVR: intravenous infusion and intravitreal injection. Intravitreal injection is an easy, safe, and well-tolerated means of administration that effectively increases retinal tissue concentrations without triggering systemic toxicity [Therefore, in our study, all patients received intravenous ganciclovir for 2 weeks, combined with.IVI of ganciclovir at a dose of 0.4 mg or 1.0 mg. We consider this regimen a suitable balance of therapeutic effectiveness, retinal toxicity, and burden for low- to middle-income patients in Southwest China. We thus undertook this investigation to compare the efficacy and injection frequency of 0.4 mg vs. 1.0 mg ganciclovir for AIDS patients with CMVR.