Effect on salivary biomarkers
MINST, periodontitis
PERIODONTITIS, ADVERSE EFFECTS
A goal of this study was to determine whether MMP-3 might be considered as a biomarker of periodontitis. A total of 46 individuals with periodontitis were included in the study. The effects of MINST and MINST + PACNs treatment on MMP-3 and TIMP-1 levels in saliva are presented in Effect of specific periodontal treatment on MMP-3 (A) and TIMP-1 (B) concentrations in saliva in pg/mL by group and visit. Periodontal treatment groups: MINST and MINST + PACNs. The boxplots of MMP-3 and TIMP-1 concentration in saliva are presented.#MINST, minimally invasive nonsurgical therapy; MMP-3, matrix metalloproteinase-3; PACN, proanthocyanidins; TIMP-1, tissue inhibitor of matrix metalloproteinase-1.The MMP-3 concentration in the MINST + PACNs group reduced statistically significantly after treatment when compared to baseline (The effect of MINST and MINST + PACNs treatment on change in MMP-3 and TIMP-1 concentrations in saliva is presented in The effect of specific periodontal treatment on change in MMP-3 (A) and TIMP-1 (B) concentrations in saliva by group. Periodontal treatment groups: MINST and MINST + PACNs. The boxplots of changes in concentrations of MMP-3 and TIMP-1 in saliva are presented.#MINST, minimally invasive nonsurgical therapy; MMP-3, matrix metalloproteinase-3; PACN, proanthocyanidins; TIMP-1, tissue inhibitor of matrix metalloproteinase-1.No adverse effects were recorded over the whole study period. In addition, we used the economic assumptions and calculated cost-effectiveness of PACNs as a product. Our conclusion is that adjunctive materials (eg, chlorhexidine chips, tetracycline fibers) are similarly cost-effective as PACNs.