Introduction
skeletal muscle, Frailty, cirrhosis, sarcopenia
SARCOPENIA, CIRRHOSIS, SYNDROME
Frailty is a complex syndrome characterized by a decrease in physiologic reserve and increased vulnerability to health stressors. In patients with cirrhosis, frailty is commonly reported as decreased physical function, decreased physical performance, and disability [Branched-chain amino acids (BCAA) including leucine, isoleucine and valine are responsible for ammonia detoxification and protein synthesis. In patients with cirrhosis, BCAA also serve a preferential source of energy for skeletal muscle [So far, the role of BCAA supplementation on muscle improvement in patients with cirrhosis has not been well determined. Previous studies assessing the role of oral BCAA supplementation on frailty and/or sarcopenia in cirrhosis are limited and demonstrated inconsistent results [