Introduction
lung inflammation, viral respiratory diseases, HD, infection, leprosy, ’s disease, Dementia, VRDs
SEVERE ACUTE RESPIRATORY SYNDROME, MAY, LEPROSY, INFECTION, CORONAVIRUS, PATHOLOGY, HANSEN
Sorok Island was established in May 1916 to quarantine leprosy patients. The public health report filed on June 4, 1946, increased the capacity of Sorokdo Leper Colony to between 8000 and 9000, making it the largest leprosarium in the world (Kim The antibiotic dapsone (4,4′-diaminodiphenyl sulfone, DDS) is predominantly associated with treating leprosy and is both an antibiotic and ANTI-inflammatory agent (Wolf et al. Acetylation of dapsone showed genetic polymorphism and reproducible individual characteristics. Acetylation of dapsone and deacetylation of monoacetyl dapsone occurred concurrently, and plasma ratios of acetylated to parent drug were attained constantly but characteristic for the individual (Gelber et al. We investigated Hansen’s disease (HD) patients with dapsone following the Dementia Management Act (DMA), enacted in 2011, in Sorokdo National Hospital. We analyzed the medical records of Sorokdo National Hospital from 2005 to 2020. We compared the incidence of viral respiratory diseases (VRDs) with dapsone prescriptions for persistent lung inflammation, inflammatory cytokine production, viral RNA, and sustained IFN response; indeed, these responses are recapitulated and contribute to the pathology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
