Image processing: Candidate processing approaches
PVC
To optimize our MK6240 processing pipeline, several approaches were evaluated. Target region SUVRs were calculated using an inferior cerebellar gray reference region (standard processing as originally developed for flortaucipir; (In addition, MK6240 scans were either unmasked (standard processing) or masked with the whole OTS mask described above (non-standard). The reverse-normalized whole OTS masks were allowed to overlap with (and thus remove) voxels in native space cortical regions defined by FreeSurfer (Finally, we applied PVC using a geometric transfer matrix approach (