Specific metabolite alterations
We next addressed the question of specific metabolite alterations between the feeding arms using a mixed effect moderated empirical Bayesian approachSummary of all metabolites and associated Human Metabolite Database (HMDB) ID number and related biological pathway whose concentration was found to change significantly over the duration of ICU stay, following removal of a non-significant feeding arm effect by collapsing data into a single dataset together with their associated Human Metabolite Database (HMDB) ID number and related biological pathway. Where two peaks of the same metabolites are seen (representing different isomers) these are numbered separately. “Unknown” refers to metabolites not seen in the HMDB.(