Analysis population
ITT population is defined as all patients who were randomized into the study.The per-protocol population includes those patients adherent to both visit and medication, respectively defined as patients who completed at least 80% of the expected routine study visits and consumed at least 80% of the prescribed assigned medication [Following the COVID-19 amendment (March 23, 2020), telemedicine visits were introduced as an alternative to in-person visits. For the per-protocol analysis purpose, these two modalities will be considered exchangeable.The safety population (full analysis population) includes all subjects participating in the trial who received at least one dose of the trial medication. The safety population does not include subjects who dropped out before receiving any treatment.