Participants and inclusion criteria
aphthous lesions, Behcet’s syndrome, stomatitis, urticaria, myopathy
MUSCULAR DISORDERS, STOMATITIS, LIVER FAILURE, MINOR, URTICARIA, SYNDROMES, RECURRENT APHTHOUS STOMATITIS, APHTHOUS ULCERS, MYOPATHY, SKIN AUTOIMMUNE DISEASE
According to the study conducted by Babaei et al. with the mean and standard deviation of the lesion diameter on the seventh day in the control group of 0.60 ± 0.69 and the intervention group of 1.29 ± 0.66 with a confidence level of 95%, a test power of 90%, and for the two-way test, by using the formula for comparing the two averages in the G-power software. The sample size of the current study was calculated 44 patients (22 patients in each group) [The patient selection was based on the inclusion criteria from those referred to Mazandaran dental school with recurrent aphthous stomatitis in the age range 20–40, reporting a history of minor aphthous ulcers in areas such as the lips and buccal mucosa. The patients were randomly divided into two groups: 22 patients in the intervention group and 22 patients in the control group. The head nurse of the dental clinic (who was not from analyzers or evaluators) registered the patients and gave the medication to participants (atorvastatin mucoadhesive tablets or placebo). This intervention took 7 days.The inclusion criteria of this study include patients with minor recurrent stomatitis, patients with aphthous lesions in lips and buccal mucosa (due to greater access and less movement that allows mucoadhesive tablets to remain on the lesion), systemically healthy, not taking immunosuppressive drugs within the past month, not using dentures, not taking antibiotics. Also, pregnant patients, people who were not able to use mucoadhesive tablets, people with syndromes manifesting aphthous-like lesions (Behcet’s syndrome), smokers, people with mucosal skin autoimmune diseases, patients with liver failure, myopathy, and muscular disorders, patients experiencing urticaria and skin and mucosal itchiness, and those who were not able to study due to personal or social reasons, were excluded from the study [