1. Introduction
Coffeeberry extract, fatigue
Background: Coffeeberry extract, rich in chlorogenic acids, shows promise in improving mood and cognition, particularly when co-supplemented with phenolic compounds. However, limited work has considered the effects of coffeeberry in isolation, especially at low doses. Objective: The current study investigated the effect of low and moderate doses of coffeeberry extract on cognition and mood. Design: This randomized, double-blind, placebo-controlled crossover design investigated three active beverages on a sample of 72 healthy adults aged 18–49 years. The investigational beverages contained 100 mg or 300 mg coffeeberry extract (standardized to 40% chlorogenic acid), or 75 mg caffeine (positive control). Cognition, mood, and subjective energy were measured at baseline and then again at 60 and 120 min post-treatment. Results: Analysis revealed no effect of 300 mg coffeeberry extract, while 100 mg resulted in increased mental fatigue during the performance of cognitively demanding tasks (Considerable interest has been placed on the potential health-promoting effects of polyphenols, specifically with regards to their effects on cognition. [Coffeeberry extract (also referred to as coffee cherry), rich in chlorogenic acids (CGA) and low in naturally occurring caffeine, is a promising candidate. Previous work has indicated that coffeeberry extract can interact with biological systems underlying brain function. For example, acute supplementation of 100 mg whole coffee fruit extract has been shown to significantly increase concentrations of brain-derived neurotropic factor (BDNF) in plasma [To date, investigations of coffeeberry extract have explored effects following single doses of coffeeberry and also when co-supplemented with additional phenolic and herbal compounds. Taking the latter as an example, in healthy, young adults, acute improvements in mood were observed following 1100 mg coffeeberry extract (440 mg chlorogenic acid, 22 mg caffeine) in combination with beetroot (10 g), ginseng (170 mg), and sage (280 mg) extracts [Trials administering coffeeberry extract in isolation to cognitively intact adults are limited; however, similar mood enhancements have been observed following 1100 mg coffeeberry extract [