2.2.1. WAS.
The evaluation of wrinkles will be carried out in a standardized way using the WAS.To ensure homogeneity in the evaluation, an intra and interobserver agreement calculation will be performed before the sample is evaluated. Each specialist will receive 20 photographs of patients who did not participate in the study to classify facial wrinkles at any given time. After 7 days they will receive the same photographs and will need to classify the wrinkles again. The agreement index will be calculated for each evaluator and between the evaluators and an acceptable value of agreement must be above 70%.