Introduction
Knee osteoarthritis, disability, pain
SECONDARY, KNEE OSTEOARTHRITIS, KNEE OSTEOARTHRITIS
Knee osteoarthritis is a world-wide leading cause of pain, disability, and reduced quality of life (QoL) [Also, less is known about the efficacy of aerobic exercises alone on knee-related QoL. Of 48 trials in a systematic review [There is still lack of evidence on the efficacy of different types of structured, easily available exercise programs beyond post-intervention assessment on knee-related QoL in younger patients with symptomatic knee osteoarthritis. The primary objective of this trial was to evaluate the efficacy of a standardized strength exercise program, or a standardized aerobic exercise program compared to usual care at 1 year on knee-related QoL in individuals with symptomatic knee osteoarthritis. We hypothesized that (1) Strength exercise was more effective than usual care on knee-related QoL at 1 year in individuals with symptomatic knee osteoarthritis, and (2) Aerobic exercise was more effective than usual care on knee-related QoL at 1 year in individuals with symptomatic knee osteoarthritis.The secondary objectives were to investigate the efficacy of respectively strength exercise or aerobic exercise compared to usual care, on pain, symptoms, function in activities of daily living (ADL) and sport/recreation, self-efficacy for pain and symptoms, health-related QoL, muscle strength and cycle-specific maximal oxygen uptake (VO