Ethics approval and consent to participate
This research was approved by the Ethics Committee of the First Affiliated Hospital of Bengbu Medical College. The ethical approval process complies with the requirements of Good Clinical Practice (GCP), the Declaration of Helsinki and relevant Chinese laws and regulations. All volunteers signed informed consent when participating in the study. The trial has been registered on the Drug Clinical Trial Registration and Information Publicity Platform. Registration number CTR20200764 at 26-Apr-2020. 