Statistical analysis
All analyses were performed for all patients who were administered with at least one dose of the research treatment. The Clopper-Pearson method was used to determine the 95% confidence interval (CI) for ORR and DCR. PFS and OS were determined using the Kaplan-Meier technique. Statistics provided clinical and demographic features, as well as AEs. We used the χ2 test or Fisher’s exact test to evaluate the relationship between ORR and exploratory subsets, and the log-rank test was employed to compare the relationships among them. SPSS software (version 25) was used to carry out the statistical analyses. All statistical tests were bilateral tests, and 