Procedures
ADVERSE EVENTS
In both treatment groups, baseline loop diuretic dose (the first inhospital dose of loop diuretics administered at the emergency department, irrespective of loop diuretic administration in the prehospital setting) was determined on the basis of the estimated glomerular filtration rate (eGFR) and outpatient loop diuretic dose (Supplementary Table In both groups, 24 h urines were collected during the first 3 days of hospitalization. In the SOC group the values of these urine collections were blinded until the end of the study. Patients were contacted by telephone 180 days after enrollment to collect vital status and (serious) adverse events.As defined in the statistical analysis plan, major protocol deviations were defined as those affecting the primary endpoint analyses (Supplementary Note 