Long-term follow-up
RECRUITMENT
After EOT, all patients move to the observational follow-up with 3-monthly visits. For patients of the MRD-triggered arm, safety follow-up starts after the last visit of the last cycle of chemotherapy with subsequent transition to observational follow-up until the end of the study (EOS).After the end of the study visit, patients are routinely followed-up and treated as per the standard of care at the discretion of the treating physician. Follow-up is planned to continue until the last patient alive has been observed for at least 2 years in total (study treatment including subsequent follow-up). Assuming 2 years of recruitment, the total observation period of the first patient may last up to 4 years. Event-free and overall-survival follow-up is recorded until the end of the overall study.