Abstract
Cancer Prev Res 2023;16:621–30Single-nucleotide, cancer chemoprevention, colorectal adenomatous polyp, colorectal polyp
COLORECTAL POLYP
Cancer Prev Res 2023;16:621–30Single-nucleotide polymorphisms in genes controlling lipid mediator signaling may modify the colorectal polyp prevention activity of aspirin. Further investigation is required to determine whether testing for genetic variants can be used to target cancer chemoprevention by aspirin to those who will benefit most.Aspirin and eicosapentaenoic acid (EPA) reduce colorectal adenomatous polyp risk and affect synthesis of oxylipins including prostaglandin E