Background
AKI, sepsis, critically ill, acute kidney injury
SEPSIS, CRITICAL ILLNESS, CRITICALLY ILL
When subscribing continuous renal replacement therapy (CRRT) to critically ill patients with acute kidney injury (AKI), intensivists lack suitable tools to assess kidney recovery and to determine optimal timing of therapy cessation. Unfortunately, CRRT modifies standard markers of kidney function, such as serum creatinine. While urine output might be a predictor for CRRT liberation, it has a low sensitivity, and heterogeneity of investigated thresholds, study outcomes and lack of validation studies hampers generalizability of study results [Recently, we investigated whether penKid may be a competent marker to assess kidney function during CRRT and found an association between low penKid values, indicating better kidney function, with early and successful liberation from CRRT. Our hypothesis was based on data that demonstrated penKid as a marker of kidney function in unstable settings, such as sepsis or critical illness [