Author contributions
CDH
EMG-K, CDH, AK, HB-N, MHO, and KH contributed to the conception and design of the study. EMG-K, CDH, MBH, and JMJ conducted the intervention study. EMG-K, TBO and AH contributed to the ultrasound and biomarker analyses. EMG-K, CDH, AK, HB-N, MHO, TBO, AH and KH analysed and interpreted data, and EMG-K and KH wrote the manuscript. All the authors have revised the manuscript critically for important intellectual content and given final approval of the version to be published. KH and AK are guarantors of this work, and as such had full access to all the data in the study and take full responsibility for the integrity of the data and the accuracy of the data analysis.