Author contributions
T.R., M.J.G., S.S., A.M.A., J.V., and P.P.C. designed the study. T.R., S.S., M.J.G., S.L.T., and C.M.H. drafted the manuscript. T.R., S.S., M.J.G., R.M.G., A.Y., D.A., R. Chaudhary, R. Chen, M.Z., C.L.-E., H.D.M., N.B., J.G., A.M., M.A., N.M., J.S., S.J., F.C., A.M.A., S.T.L., K.L.D., and C.M.H. carried out the investigation, had access to the data, interpreted the analyzed data, and had final responsibility for the decision to submit for publication. All authors critically reviewed the manuscript and approved the final version. An independent data manager and the senior authors had access to all of the data in the study and take responsibility for the integrity of the data. Two independent groups of statisticians had access to all of the data in the study and take responsibility for the accuracy of the data analysis.