Author contributions
DSS
RECRUITMENT
CL was responsible for study design, study set-up, study oversight, data analysis and writing of the manuscript. SA was responsible for data collection, study oversight and editing of the manuscript. QL was involved in oversight of the computational modelling and editing of the manuscript. GS was involved in the study design, study oversight and editing of the manuscript. TS was involved in participant screening and recruitment, data acquisition and editing of the manuscript. AS was involved in participant screening and recruitment, data acquisition and editing of the manuscript. EBP was involved in participant screening and recruitment, data acquisition and editing of the manuscript. NS was involved in participant screening and recruitment, data acquisition and editing of the manuscript. OOH was involved in participant screening and recruitment, data acquisition and editing of the manuscript. AJ was responsible for medical oversight, blood sample collection and editing of the manuscript. CB was responsible for medical oversight, blood sample collection and editing of the manuscript. RNC was involved in oversight of the computational modelling and editing of the manuscript. TWR was involved in study design, study oversight, statistical advice and editing of the manuscript. DSS was involved in study design, study oversight and editing of the manuscript. GMK was involved in study design, study oversight, allocation to treatment group, statistical advice and editing of the manuscript. BJS was involved in study conception, study design, study oversight, statistical advice and writing of the manuscript. CL and SA contributed jointly to the study.