Risk factors and prediction of postoperative seizure occurrence in patients with glioma
glioma, postoperative seizure, seizures
GLIOMA, COMPLICATION
Postoperative GRE is a disturbing complication to both patients and treating physicians. Most neurosurgeons routinely prescribe postoperative AED prophylaxis for patients with glioma, even though their ability to reduce seizures is not clear [This is the first study to generate a predictive gene-signature for postoperative seizure occurrence in patients with DHGG. We further developed an integrated prediction model using both gene expression and clinical data. Age, temporal lobe involvement, preoperative GRE history, and gene-signature-derived risk scores were identified as independent risk factors for postoperative seizure occurrence and included in the model. Of these, gene-signature-derived risk score was the most significant. Age, temporal lobe involvement, and preoperative GRE have also been confirmed as predictors of postoperative seizures by previous studies [