Associations of change in DNAm age with changes in physical, psychological, and cognitive functions from baseline to post-intervention
Cancer, Depression, Fatigue
CANCER
From baseline to post-intervention, the change in accelerated DNAm ages, as determined using GrimAge, PhenoAge, and DunedinPace were correlated with the change in distance walked on 6-minute walk test (6MWT) and grip strength. Decreases in accelerated GrimAge (r = − 0.47, Correlation between changes in accelerated DNA methylation age and changes in physical, psychological, and cognitive functions. Δ; changes from baseline to post-intervention; 6MWT, 6-minute walk test; ADL, Activities of Daily Living; BFI, Brief Fatigue Inventory; CES-D, Center for Epidemiological Studies Depression; FACT-Leu, Functional Assessment of Cancer Therapy-Leukemia; IADL, Instrumental Activities of Daily Living; SPPB—Short Physical Performance Battery; vSPPB—Virtual Short Physical Performance Battery