4. Discussion
MR, intestinal dysbiosis, T2DM
TYPE 2 DIABETES MELLITUS
In this study, we executed a bi-sample Mendelian randomization (MR) investigation, using data from the MiBioGen consortium and the consolidated GWAS dataset, to appraise the cause-and-effect relationship between particular intestinal microflora and T2DM. We identified two genera as protective factors for T2DM, namely genus.Numerous recent studies have consistently reported a strong correlation between gut microbiota and type T2DM (For the other four genera identified in this study besides genus.It is well known that T2DM cannot be completely cured under the current medical conditions, so it is crucial to prevent the occurrence of T2DM. Several reports have shown that intestinal dysbiosis and a decrease in short-chain fatty acid-producing bacteria increase the risk of type 2 diabetes mellitus (Traditional observational studies measure environmental exposure factors that are associated with behavioral, social, and psychological factors, resulting in bias. MR, however, is not affected by these confounding factors. Relative to other methods, MR has less measurement error in relation to its effects, and data from the GWAS are relatively easy to obtain and less costly when conducting MR analyses.