Introduction
allergic, postoperative infections, implant failure
INFECTIOUS ENDOCARDITIS, COMPLICATIONS, POSTOPERATIVE INFECTION
Oral implants are considered a predictable and safe treatment modality for the rehabilitation of missing teeth [Consequently, researchers have advocated prophylactic antibiotics to prevent postoperative infections and oral implant failures [Prophylactic antibiotics are generally recommended during surgery for patients at risk of infectious endocarditis, with reduced host response, surgery at infected sites, extensive and prolonged surgeries, and the implantation of large foreign materials [Recent systematic reviews and meta-analyses of randomised clinical trials (RCT) [Despite current studies published in this field, there is a lack of consensus among clinicians while prescribing antibiotics in oral implant surgery. Moreover, their prescriptions may not frequently follow evidence-based recommendations [Recent surveys have confirmed that more than half of the dentists who routinely place implants prescribe antibiotics [Amoxicillin is one of the most extensively studied and prescribed antibiotics [Clindamycin has appeared as one of the choices for oral implant surgery according to multiple surveys performed in the last few years among oral care professionals [A single 600-mg dose of clindamycin 1 h preoperatively was reported as one of the routinely prescribed regimens for implant surgery in Sweden [Clindamycin has been studied to this purpose previously [According to several researchers and national guidelines, clindamycin is principally prescribed for patients allergic to amoxicillin to prevent the loss of dental implants. However, no clinical trial has been published yet to support its efficacy neither in allergic nor in non-allergic patients to penicillin. Therefore, we intended to conduct an RCT that provides information regarding this. As a consequence, we aimed to assess the effect of a single 600-mg dose of oral clindamycin administered 1 h pre-operatively in reducing early implant failure and on post-surgical complications in healthy adults undergoing a conventional implant installation.The null hypothesis was postulated as follows: there are no differences in the cumulative incidence of implant failures following an oral implant surgery in medically and periodontally healthy adults and straightforward conditions upon administering a single 600-mg dose of oral clindamycin 1 h preoperatively versus placebo.