2.1.2. Specific Objectives
SECONDARY
As a secondary outcome, we evaluated whether the disparity between postprandial (after-meal) and preprandial (before-meal) blood glucose levels of fasting, lunch and dinner, separately, could be altered by the use of melatonin. This evaluation aims to determine whether melatonin use has any impact on glucose fluctuation at specific times of the day.In order to analyze the effect of melatonin after a greater number of days of use, we analyzed the glycemic variability obtained on the last day of measuring capillary glycemic levels.We also conducted an analysis of the glycemic variation coefficient (standard deviation/mean glycemic value) of capillary blood glucose levels during the administration of the placebo and melatonin. We considered the condition to be stable if this value was below 36% and unstable if it exceeded this threshold. Furthermore, we evaluated whether there was a statistically significant difference in the glycemic variability coefficient obtained from each patient between the use of melatonin and the placebo.Finally, we evaluated whether the use of melatonin altered the glycemic variability between post-dinner on Day 6 and pre-breakfast on Day 7.