Author contributions
XFG
XFG as the chief investigator of the study, conceived the study, and is responsible for the overall conduct of the study. YJG, YNZ, and MZ participated in the study design and patient enrollment. YH and CJC are responsible for the clinical input. CZD and XFG initiated the trial and supervised the drafting of the manuscript. All the authors have read and approved the final manuscript and agree to be accountable for all aspects of the work.