Endpoints
metabolic acidosis, death, hyperkalemia
METABOLIC ACIDOSIS, FLUID OVERLOAD, PULMONARY EDEMA
The primary outcome was death from any cause at 90 days after randomization.Secondary endpoints included ICU and hospital mortality, ICU and hospital length of stay, RRT-free days, RRT dependence at hospital discharge, and renal function in surviving patients who were not RRT dependent at hospital discharge (creatinine absolute values and creatinine progression, expressed as percentage change in creatinine values from baseline values).In the present analysis, we evaluated the criteria for emergency renal replacement therapy within 7 days after randomization in all 3 groups, notably: severe metabolic acidosis (defined as a pH less than 7.15 and a base deficit of more than 5 mmol per liter or a bicarbonate level of 18 mmol or less per liter), severe hyperkalemia (defined as a potassium level of more than 6.5 mmol per liter with characteristic electrocardiographic changes) and fluid overload (defined as extravascular fluid overload that was refractory to diuretics, with pulmonary edema).