Study design
Tumors, Cancer
TUMORS, PEDIATRIC CANCER, CANCER
This study was completed through the Sunshine Project, a multi‐institutional clinical trial consortium sponsored by the National Pediatric Cancer Foundation. Moffitt Cancer Center was the coordinating center, and the study was approved by the Moffitt Cancer Center Institutional Review Board (IRB) and each participating institution's IRB. The trial was registered at Dose escalation followed a 3 + 3 design.Patients were evaluated with cross‐sectional imaging within 14 days of therapy initiation and before course three, five, and every three cycles thereafter. Responses were evaluated using the Response Criteria in Solid Tumors.