2.2. Patients recruitment
DISEASE, RECRUITMENT
A total of 480 aged women diagnosed with POR will be included in the study. Potentially eligible patients will be recruited by the clinicians in the reproductive center of ten tertiary hospitals. The detail about the trial will be introduced to them on their first visit. After a wash-out period of at least 2 weeks, eligible women will be arranged a second visit on day 2 or 3 of a menstrual cycle. Then, all couples will provide written informed consent before participation following the approval by the ethics committees of participating reproductive centers. Given the high prevalence of the disease and the large outpatient volume in participating centers, we will not apply other methods of recruitment.