Introduction
ADHESION, RECRUITMENT
Periodontal regeneration is a complex process that involves coordinated activities and interactions of many cell types, extracellular matrix, cytokines, and specific growth factors to restore tissue integrity. The most important challenge facing periodontal regeneration is cellular insufficiency.Apoptosis is initiated when failure in adhesion in many different cell types occurs.Hydrogels are natural or synthetic biocompatible polymers that are widely used in periodontal tissue engineering as a delivery material for different biologics.the convenience with which cationic molecules can be loaded for its polyanionic charge.Despite its proven potential in enhancing cellular adhesion, RGD significance in periodontal regeneration is insufficiently studied. To maximize cellular recruitment and improve defect stability, this study was conducted to clinically and biochemically evaluate the effect of using RGD peptide carried on hydrogel in treating human intrabony defect using the MIST approach.