Primary analyses predicting final MADRS score
depression, Depression
CORTEX
We integrated all Functional connectivity pairs associated with final depression severity in initial blinded trailMADRS, Montgomery-Asberg Depression Rating Scale; DLPFC, dorsolateral prefrontal cortex; dACC, dorsal anterior cingulate cortex; CCN, cognitive control network; OFC, orbitofrontal cortex; PCC, posterior cingulate cortex (bilateral); mPFC, medial prefrontal cortex; DMN, default mode network; rACC, rostral anterior cingulate cortex; sgACC, subgenual anterior cingulate cortex (bilateral).In this general linear model examining data from the blinded trial of escitalopram and placebo, the outcome variable was final MADRS score. A positive relationship indicated that higher functional connectivity between ROI seeds was associated with a higher final MADRS score. A negative relationship indicated that higher functional connectivity between ROI seeds was associated with a lower final MADRS score.