Participants and criteria of eligibility
fatigue, COVID-19 disease, pain, infection, SARS-CoV-2.No, disability
MUSCLE WEAKNESS, DISEASES, DISEASE, RECRUITMENT, INFECTION, TERMINAL DISEASE, SEQUELAE
The sample will be made up of 120 eligible participants, over the age of 60 years who have had COVID-19 disease and present persistent COVID-19 symptomatology with sequelae of fatigue, muscle weakness, pain, difficulty in performing daily life activities, etc. diagnosed by the corresponding physician.Participants will be recruited from internal medicine services and patients with post-COVID-19 sequelae will be selected from the database of the hospital and primary care centers who have given their consent to be contacted for participation in the research project. The recruitment status of the participants will be ongoing at the time of manuscript submission.Candidates will fulfill the following inclusion criteria:Persons of both sexes (and different expression of gender) older than 60 years of age.Molecular diagnosis (reverse transcription polymerase chain reaction [RT-PCR]) of infection by SARS-CoV-2.No history of physical diseases and no disease or disability that limits participation in the exercise program or precludes the corresponding measurement/evaluations.Be able to communicate without difficulty.Be able to understand the objectives of the project and provide written, informed consent.Not taking any medication that can affect normal performance of the exercise program and the evaluations. Specifically, patients who were treated with IL-6 receptor antagonists (example: tocilizumab) during the last month will be excluded. This type of medications will interfere with the exercise adaptations of the cardiorespiratory system.The following exclusion criteria will apply:Having acute or terminal disease or any other disease that may affect the normal practice of a supervised exercise program and the corresponding evaluations.Consumption of any amount of alcohol or drugs during the study.Be performing any type of activity that may interfere in carrying out the supervised exercise program or the evaluations.Not completing the study once initiated or wishing to participate in the control group.To calculate the sample size of this project a type 1 (α) error of 5% and a 95% confidence interval with a level of precision (d = 0.095) was established for the test of proportional hypotheses resulting in a sample size of To know the sample size more precisely in the hypothesis test of means it will be necessary to carry out a pilot study which will provide the size of effect and statistical power (0.80), determine the analysis to perform, obtain delta values in the units corresponding to the principal study variable as well as know the standard deviation. Since this cannot be carried out, the sample size described in the study by Udina and cols. (2021) [