5.1. Limitations in This Current Study
anxiety
Importantly, a sample size attrition of 46% from baseline to the second time point (Secondly, GABA concentration levels in the brain derived from spectral data requires high amounts of data modelling to expose GABA peaks, and there is debate on the optimal methods for sequencing, spectral analysis, quality parameters, or data modelling of ‘contaminants’ such as macromolecules. All magnify the risk of measurement errors, among other methodological issues [Thirdly, scan novelty may also be an influencing factor in participants with clinical anxiety. This current study did not collect data as to whether participants were familiar with MRI scan environments. A ‘sham’ scan session for each participant might have reduced this confound.For these reasons, this study’s novel findings should be considered pilot data at best, offering a novel insight into the pattern of GABA levels in a GAD as a product of Kava, as well as an example of greatly needed biomarker research for the benefit of clinical anxiety.