Introduction
cancer deaths, cancer
CANCER, SOLID TUMORS
In 2020, there were almost 10 million cancer deaths and approximately 19.3 million new cancer cases worldwide [Poly(ADP-ribose) polymerase (PARP) inhibitors target the enzymes PARP1 and PARP2, which play key roles in DNA repair [Talazoparib (oral, 1 mg once daily [QD]) is approved as a monotherapy for the treatment of patients with human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer with a germline When this study was initiated, no Chinese patients were involved in prior global talazoparib studies. The purpose of this open-label phase 1 study (NCT04635631) was to evaluate the PK, safety, and antitumor activity of talazoparib monotherapy in Chinese patients with advanced solid tumors.