Procedures
BLOOD
Vaccinations were given in accordance with the clinical trial protocol and good clinical practice (GCP), with intervals for primary vaccinations as recommended in FASS (Pharmaceutical Specialties in Sweden): FSME IMMUN, three doses 0-, 1- and 5-month intervals; IXIARO, two doses, 0- and 1-month interval; Stamaril, one dose. For cohorts A1, A2, B1, B2, C, and D, blood and serum were set to be sampled before each vaccination, and then at day 7 (+/- 1 day) and at day 14 after each vaccination. Blood and serum were also set to be sampled 30 days after the last vaccination. For cohort E, blood and serum were sampled before the vaccination, and then after vaccination at day 7 (+/- 1 day), at day 14, at day 30 (+/-2 days), day 37 (+/- 1 day), day 44 (+5 days) and day 60 (+14 days). This schedule led to the following approximate time allocations in terms of days for blood and serum samplings: cohorts A and C, days 0 (first vaccination), 7, 14, 30 (second vaccination), 37, 44, 180 (third vaccination), 187, 194, and 210; cohorts B and D, days 0 (first vaccination), 7, 14, 30 (second vaccination), 37, 44, and 60; cohort E, days 0 (vaccination), 7, 14, 30, 37, 44, and 60 (