2.3. Statistical Analyses
Statistical analyses were performed using SPSS vers.25.0 (IBM, Armonk, NY, USA). The normal distribution of variables was evaluated using the Shapiro–Wilk test. According to the study design, variables were collected and compared at baseline and after Algorithms 1 and 2 (study phases). Patients were analyzed both as a whole and divided according to the type of treatment (MDI or CSII). The ANOVA and the related-sample Friedman’s two-way ANOVA by ranks were used to compare variables collected at baseline and with Algorithms 1 and 2. The Bonferroni post hoc test and Wilcoxon signed rank test were used to compare the glucose metrics between study phases. The sample size was not driven and was arbitrarily chosen to collect adequate information on protocol efficacy and safety.