Statistical analyses
EAE, MULTIPLE SCLEROSIS
For sample size estimation, a systematic search using PubMed, MEDLINE and Web of Science was performed to identify prior trials using SHED in murine EAE or cuprizone models. The search string was “animal or animal model” AND “multiple sclerosis or MS” AND “stem cells from human exfoliated deciduous teeth” or “SHED”. The search was performed in June 2020. One trial was identified using SHED in an EAE model and the EAE clinical scores from this trial was used for sample size estimation [The Shapiro–Wilk test was used to test normal distribution. Students t test was used to analyze parametric data and The Mann–Whitney U test for non‐parametric data. An interrater analysis was performed by calculating the kappa statistic to assess conformity in the rating of myelination in the luxol fast blue staining. All calculations are carried out using STATA 17.0 (Stata Corp, TX, US). Differences were considered significant at p < 0.05.