Abbreviations
death, breast tumors, breast cancer, breast cancer deathconfidence, reduced cancer, Tumors, breast tumor, tumors, breast cancer‐related death
RECURRENCE, BREAST TUMORS, BREAST CANCER, RECURRENT CANCER, TUMORS, BREAST TUMOR, TUMORS
Downregulation of the DNA repair protein WD40‐encoding RNA antisense to p53 (WRAP53) has been associated with radiotherapy resistance and reduced cancer survival. The aim of this study was to evaluate WRAP53 protein and RNA levels as prognostic and predictive markers in the SweBCG91RT trial, in which breast cancer patients were randomized for postoperative radiotherapy. Using tissue microarray and microarray‐based gene expression, 965 and 759 tumors were assessed for WRAP53 protein and RNA levels, respectively. Correlation with local recurrence and breast cancer‐related death was assessed for prognosis, and the interaction between WRAP53 and radiotherapy in relation to local recurrence was assessed for radioresistance prediction. Tumors with low WRAP53 protein levels had a higher subhazard ratio (SHR) for local recurrence [1.76 (95% CI 1.10–2.79)] and breast cancer‐related death [1.55 (1.02–2.38)]. Low We have studied the levels of WRAP53, a DNA repair protein, in 965 breast tumors and correlated this with the prognosis and effect of radiotherapy treatment. Tumors with low levels of WRAP53 had a higher risk for locally recurrent cancer and death from breast cancer. Low levels of breast cancer deathconfidence intervalestrogen receptorgene set enrichment analysishuman epidermal growth factor receptor 2ipsilateral breast tumor recurrencenormalized enrichment scoreprogesterone receptorreferenceradiotherapystandard deviationsubhazard ratiotissue microarrayWD40‐encoding RNA antisense to p53