Study population
Melanoma
MELANOMA, AUTOIMMUNE DISEASES, LYMPH NODE METASTASIS, METASTASES, STAGE III MELANOMA
Patients were included in the NKI and Melanoma Institute Australia (MIA, Sydney, Australia). Eligible patients were ≥18 yr and had resectable stage III melanoma of cutaneous or unknown origin with at least one lymph node metastasis measurable according to RECIST v 1.1, a World Health Organization performance status of 0 or 1, and normal lactate dehydrogenase (LDH) levels. Key exclusion criteria included a history of in-transit metastases within 6 mo prior to inclusion, autoimmune diseases, and prior treatment with checkpoint inhibitors targeting CTLA-4, PD-1 or PD-L1, BRAF ± MEK inhibition, or radiotherapy.