Strengths and Limitations
dementia, MCI, cognitive impairment
These results should be interpreted within the context of the following strengths and limitations. Strengths include the use of complete SPRINT data and a randomized design. Additionally, cognitive outcomes were adjudicated by clinical experts in the care of persons with cognitive impairment and classified into meaningful clinical categories (no impairment, MCI, and probable dementia). Although we observed evidence of risk magnification, greater absolute risk reduction among patients with higher baseline risk of cognitive outcomes, the 95% CIs were wide among participants with high estimated absolute risk or an inverse association was observed due to small sample size (