Introduction
cancer, AML, blood cancer
INFILTRATION, CANCER, BLOOD CANCER, ACUTE MYELOID LEUKEMIA, DISEASE, AML, PROLIFERATIVE
Clinical studies have been reported in which autologous γδ T lymphocytes have been generated and infused in cancer patients.Acute myeloid leukemia (AML) is a blood cancer affecting adults and children, characterized by infiltration of bone marrow and other tissues by clonally proliferative immature myeloid cells. While AML may be cured using chemotherapy, allogeneic stem cell transplantation and novel targeted therapies in select cases, significant proportion of patients have either relapsing or refractory disease. New treatment approaches are therefore a research priority.This article describes a phase I clinical trial of an allogeneic γδ T cell product of the Vγ9Vδ2 subtype, expanded using zoledronic acid and interleukin-2 (IL-2) in patients with relapsed or refractory AML.