Statistical analysis
Response was summarized with the use of frequency counts and percentages, with exact 95% confidence intervals (CIs) calculated. Fisher's exact test was used to examine the association between two categorical variables. PFS and OS were estimated using the Kaplan–Meier method, and 95% CIs were calculated. The Cox proportional hazards model using the stepwise method was used to identify prognostic factors. Statistical analysis was performed using SPSS Statistics V.26.0 (IBM). To calculate the sample size, one arm binomial was used in SWOG's Statistical Tools (