Adherence
Participant retention and adherence to the protocol are facilitated through regular contact via telephone, short message service, clinic or home visits. Contact is weekly during dosing (starting 7 days from previous dose) then monthly thereafter until the final study visit. A maximum of three consecutive days of contact are attempted for each scheduled visit or dose. Where possible, ingestion of study medicine is supervised by clinic, hospital or study staff. Unsupervised, self-administered doses are verified by phone. When dosing is complete the remaining volume of the used bottle is recorded, and it is stored securely and separately from the unused medicines. Empty dosing syringes are not collected.