Non-hematologic toxicity
asthenia, nausea, fatigue, diarrhea, PET-MF, pyrexia, PPV-MF, MPNs
ATRIAL FIBRILLATION (AF), PHILADELPHIA CHROMOSOME
The most common non-hematologic AEs (occurring in ≥ 5% of patients) included nausea, diarrhea, pyrexia, fatigue, and asthenia. Atrial fibrillation (AF) occurred in 3.9% of patients (patients with concomitant AF were excluded from the COMFORT trials).Elevated alkaline phosphatase (AP) levels have been described in Philadelphia chromosome–negative MPNs, and There were no relevant changes in bilirubin, aspartate aminotransferase, alanine aminotransferase, gamma-glutamyl transferase, glutamate dehydrogenase, serum protein, or lipase levels during RUX treatment. Also, urea, sodium, potassium, and chloride levels were not elevated at baseline and did not change relevantly during RUX treatment. Median creatinine slightly increased over time, with the increase being most severe in patients with PET-MF and PPV-MF (