2.4. Intervention
The intervention group self-administered an oral dose of 150 mg CBD twice a day (morning and evening, 300 mg/day), starting the day before chemotherapy and continuing for eight days totally in every cycle of chemotherapy. This dose schedule was chosen because animal models suggest that neuroinflammatory changes in nerve cell ganglia occur in the first 24 h and up to 6 days following injection of classical chemotherapeutic agents [The dose of CBD was apportioned by the patients using a syringe. The CBD oil was manufactured, packaged, and labeled by Glostrup Pharmacy adhering to GMP standards, as described earlier [