Conclusions
SARS-CoV-2 infection, throat
SARS-COV-2 INFECTION
In this randomized clinical trial of participants from SARS-CoV-2 test centers in Denmark, we found that the sensitivity of SARS-CoV-2 rapid antigen testing was significantly higher for HCW-collected throat specimens than for HCW-collected nasal swabs. For symptomatic individuals, self-collected nasal specimens had a higher sensitivity than self-collected throat specimens. Our results indicate that the throat plays an important role in the initial phase of SARS-CoV-2 infection and that throat specimens should be collected together with nasal specimens to improve sensitivity for rapid antigen testing in both health care and home-based settings.