MTN-035 placebo study products.
The products were administered in order of the assigned sequence and prior to each respective product use period. Participants were instructed to use one dose of the assigned study product between 30 minutes and 3 hours prior to RAI, following their usual pre-RAI practices, and not to use more than one product dose in 24 hours. If a participant did not engage in RAI in a given week, they were asked to insert a dose of the product in the absence of RAI. Participants self-administered the first dose of each product in the clinic to ensure correct administration.The schedule of participants’ study activities is depicted in 