Prognostic biomarkers of radiographic changes
fibrosis, IPF, Fibrosis
REGRESSION, OPACITIES, FIBROSIS, FIBROSIS
IPF is recognized in HRCT by subpleural lower lobe reticular opacities and honeycombing (Fibrosis changes in left and right lower lungs by baseline (A and B) lipid and (C and D) protein biomarker profile. A multivariate linear regression model adjusted for the following covariates: age, sex, baseline FVC %pred, baseline DLCO %pred, and geographical region, was used to assess the association between (A and B) lipids, and (C and D) protein biomarkers with fibrosis change from baseline in the (A and C) left lower lungs, or (B and D) right lower lungs. #The LPA model absolute coefficients ranged from 4.27 to 7.71, which showed that for every twofold increase in baseline LPA levels, fibrosis increases by an additional 4.27%–7.71% in the lower left or right lung in 72 weeks, with all other covariables held constant. TAG species were not prognostic of fibrotic changes. Higher levels of SPD at baseline were also associated with greater increases in fibrosis in the lower lungs (