Endpoints
death, SD
DISEASE, DISEASE PROGRESSION, SECONDARY, METASTASIS
The primary endpoint of this study was the ORR, defined as the proportion of patients who achieved a confirmed CR or PR. Secondary endpoints included OS, which was defined as the time from obtaining informed consent to death from any cause, and PFS, defined as the time from obtaining informed consent to disease progression or death from any cause, whichever came first. Other secondary endpoints were the CBR, defined as the proportion of patients with confirmed CR, PR, or stable disease (SD) lasting for at least 24 weeks, and the DoR, defined as the time from the first documented response to disease progression for patients with confirmed CR and PR. Safety profiles were also assessed as a secondary endpoint. Additionally, exploratory endpoints included the TTR, which was calculated as the time from treatment initiation to the first documented response, and the incidence of CNS metastasis as the first site of disease progression.