Discussion
hypertensive
MYOCARDIAL ISCHEMIA
The present study was conducted to determine the acute effects of dietary NOIn this study, the BRJ used in the intervention phase presented high levels of NOThe serum NOThere was a significant increase in peripheral BP in the control phase, which was attenuated in the intervention phase after the ingestion of BRJ. Most studies in normotensive individuals have evaluated chronic consumption of BRJ and have a decrease in BP levels.These controversial results in hypertensive individuals could be attributed to the great heterogeneity of the study design concerning the BRJ volume (140mL to 250mL), NOThe behavior of central BP was similar to the peripheral BP, with a significant increase in the control phase, which was not observed in the beetroot phase. To date, there are no studies evaluating central BP after inorganic NOIn this study, ED showed a significant reduction after ingestion of BRJ. Hughes et al.SEVR is a sensitive marker of subendocardial oxygen supply and demand that correlates with myocardial ischemia.The microvascular reactivity measured by the percentage of perfusion increase in PORH showed a significant increase after ingestion of BRJ, demonstrating an improvement in endothelial function. Thus far, no clinical protocols are evaluating the effects of dietary NOSome limitations of this study should be considered. Exclusion criteria made it difficult to enroll participants, especially regarding the use of beta-blockers and statins, drugs widely used in hypertensive patients due to the other comorbidities. However, the study population was more numerous than the estimated sample size and similar to the other studies. The intervention period of 150 minutes in the fasting period may have influenced the BP increase, which was more evident in the control phase. On the other hand, this effect contributed to better observation of the dietary NO3‾ action on BP levels. Finally, we conducted a single-dose intervention; therefore, our findings cannot be compared with medium and long-term effects.