Discussion and potential impact
GHD
ADVERSE EFFECTS, GHD
Five previous studies have demonstrated reversal of GHD (mean 49%; range 19–95%) with earlier re-testing, before or during puberty [Assuming that GH discontinuation will be non-inferior to GH continuation, the expected impact of the study will be:A change in inter/national guidance on GH therapy in I-GHDImproved QoL, fewer injections and clinic visits, diagnostic certainty, and earlier discharge from care for reversed GHD patientsReduce health care costs, with savings estimated at £2 million per year in the UK alone, and potentially hundreds of millions worldwide, every year. In turn, such huge cost savings will benefit patients with other conditions needing expensive therapies, particularly in resource-limited countries.Reduce the risk of long-term potential adverse effects