INTRODUCTION
DLB, parkinsonism, dementia, Abundant Lewy, Alzheimer’s disease, Parkinson’s disease, PD, motor dysfunction, Dementia, PDD
VASCULAR DEMENTIA, PARKINSONISM, DISEASE, DISORDERS, DEMENTIA WITH LEWY BODIES, CORTEX
Along with Alzheimer’s disease and vascular dementia, dementia with Lewy bodies (DLB) is one of the three most common forms of dementia, accounting for approximately 10% –20% of dementia cases [Abundant Lewy bodies composed of alpha-synuclein in the cerebral cortex, midbrain, or peripheral autonomic nervous system of patients with DLB and Parkinson’s disease (PD) dementia (PDD) indicate that both disorders are part of the same disease spectrum and present similar pathological features [A survey of patients with DLB revealed that parkinsonism is one of the most troubling symptoms in daily life and that this treatment need remains unmet [According to the Clinical Practice Guideline for Dementia 2017 by the Japanese Society of Neurology [Zonisamide, originally an antiepileptic drug, has several mechanisms of action to improve motor dysfunction associated with PD and DLB, such as dopaminergic and nondopaminergic mechanisms, including inhibition of monoamine oxidase B activity, inhibition of T-type Ca