Clinical Efficacy
DER
It is difficult to generalize that AmBisome is equally effective but safer than amphotericin deoxycholate; it depends on the dose of both drugs. Hamill et al [Mortality in the van der Horst trial was 5.5% at 2 weeks and 3.9% at between 2 and 10 weeks, and it is sometimes assumed therefore that 10-week mortality was 9.4%. However, the trial was conducted in 2 stages, and only participants who responded to treatment at 2 weeks were continued in the trial and re-randomized to fluconazole vs itraconazole for consolidation treatment [