Outcomes
Bradycardia, bradycardia, hypotension
SECONDARY
The primary outcome was the percentage of time within the target sedation range without rescue sedation. The secondary outcomes included ventilator-free hours within 7 days, successful extubation (defined as no reintubation or tracheostomy within 48 h after extubation), length of ICU stay, and 28-day mortality. Patients were considered hospitalized for 28 days if died within 28 days. During the study period, occurrence of hypotension (systolic blood pressure below 80 or diastolic blood pressure below 50) and bradycardia (heart rate below 50) were recorded. Bradycardia was treated with medication to increase heart rate, and hypotension was treated with vasopressors.