Author contributions
C.K.M. obtained funding for the study. C.K.M., C.H., J.W.A., J.L.D., J.M.O., C.M.C., M.I.C. and G.D.F. designed the study. C.K.M. and C.H. oversaw data acquisition, and S.Y., C.H. and C.K.M. analyzed and interpreted the data. C.H. and C.K.M. drafted the manuscript; all authors provided critical revisions for important intellectual content. C.K.M. was responsible for the overall study supervision, and F.L.G. was responsible for the medical supervision.