Blood analysis
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Samples of venous blood were obtained by an independent nurse from each participant after fasting for 12–14 h at 8–9 AM and frozen at − 80 °C until the analysis to evaluate fibrinogen, KCCT, PT, serum TC, fibrin fragment D, and CRP levels. INNOVANCE® fibrin fragment D (Siemens Healthcare Diagnostic Products GmbH) was used to measure plasma fibrin fragment D levels by a particle-enhanced immunoturbidimetric assay for quantifying cross-linked fibrin degradation products (fibrin fragment D). All samples were analyzed by the same accredited medical laboratory before the intervention and after its completion