Clinical significance
periodontitis
PERIODONTITIS, PERIODONTAL DISEASE, PCT, INFLAMMATORY RESPONSE
This research work was carried out to test curcumin gel which is a natural herbal product as a promising local drug delivery agent with the advantages of inherent availability, low cost, and fewer side effects. Additionally, this research evaluated salivary PCT as an inflammatory biomarker and the efficacy of applied curcumin gel on its levels during the treatment of periodontitis patients.As demonstrated in the study, curcumin gel has been proven to be an encouraging local drug delivery with a positive influence in all measured clinical indices with no reported side effects. Additionally, there was a positive correlation between PCT and clinical indices before treatment due to common contributing factors including the presence of the subgingival bacteria and subsequent inflammatory response. Therefore, it can be concluded that PCT can be used as an inflammatory biomarker in the assessment and diagnosis of periodontal disease.