Distribution-based methods of score interpretation
In addition to the anchor-based methods, distribution-based methods were also used to determine a meaningful change for the domain scores. These methods aimed to identify the smallest amount of change which exceeded measurement errors. Thus, the distribution-based estimates, in the form of 0.5 SD and the SEm, were calculated for the domain scores. For PIB weekly mean, the distribution-based methods suggested a point reduction exceeding 1.13 to be meaningful (