Introduction
nervous system disorders, Neurofibromatosis, NF2, 3RP-NF, NF1
NERVOUS SYSTEM DISORDERS, NEUROFIBROMATOSIS, NEUROFIBROMATOSES, SCHWANNOMATOSIS, SECONDARY
Neurofibromatoses (NF; NF1, NF2, and schwannomatosis) are nervous system disorders unified by risk of nerve sheath tumorsNeurofibromatoses share poor quality of life (QOL),We used a sequential approach to develop and optimize the Relaxation Response Resiliency Program for Neurofibromatosis (3RP-NF), a remote psychosocial program to improve QOL among geographically diverse patients with NF. Using qualitative interviews, an open pilot with exit interviews,We aimed to establish the efficacy and durability of 3RP-NF vs HEP-NF over 12 months among English-speaking adults with NF worldwide. We hypothesized that participation in 3RP-NF would be associated with improvement in the primary (physical health and psychological QOL) and secondary (social relationships and environmental health QOL) outcomes compared with those participating in the HEP-NF program and that these improvements would persist at 6- and 12-month follow-up.