2.3. Allocation to intervention
Participants were randomly assigned to receive SDE (150 mg in 2 mL vehicle; Lumosa Therapeutics Co., Ltd., Hsinchu, Taiwan) or vehicle solution (2 mL of mixture of benzyl benzoate and sesame oil) in permuted blocks of 10 using a computer-generated list. Dose of SDE used in this study was derived from the previous pharmacokinetic study