Introduction
cancer, TNBC, breast cancers, tumor
TRIPLE-NEGATIVE BREAST CANCER, TUMOR, BREAST CANCER, PROLIFERATION, CANCER, TUMOR ANGIOGENESIS, -20, TUMOR GROWTH
Triple-negative breast cancer (TNBC), characterized by the absence of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) expression, accounting for about 15-20% of breast cancers [Vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR) signal pathway plays an important role in tumor angiogenesis, which is essential for tumor growth and spread [Etoposide, a cell cycle-specific antitumor drug, inhibits tumor cell proliferation by forming complexes with topoisomerases that interfere with DNA repair [Recently, due to the nature of COVID-19 pandemic, many cancer patients are unable to receive intravenous drug therapy on time. Thus, there is an urgent need to explore the accessible and easy-to-use treatment options for advanced TNBC patients. This study aimed to investigate the efficacy and safety of oral apatinib plus etoposide for pretreated patients with advanced TNBC.