Interventions
DMD, acute adenoidal infections, hypertrophic adenoids, choanal space occlusion
RECRUITMENT
Upon enrolment (T0), a complete clinical history (including the number of documented acute adenoidal infections occurring in the previous 3 months) was taken, and the child’s gender and age were recorded; all the children underwent a detailed otorhinolaryngological clinical examination including nasopharyngeal flexible video-endoscopy (performed by the same trained examiner) aimed at grading the blockage of nasopharynx space by hypertrophic adenoids expressed as the percentage of choanal space occlusion.Upon enrolment, the patients were double-blindly randomized 1:1 via a random number generator to:the control group, which received a placebo nasal spray, 1 puff each nostril twice a day for 90 days;the study group, which received the administration of Rinogermina spray (DMD ITALIA s.r.l, Rome), 1 puff each nostril twice a day for 90 days:The compliance to the assigned treatment was evaluated by counting the number of dispensed and returned devices.Clinical assessment was repeated at the end of the treatment (90 days after recruitment, T1), and 90 days later (90 days after treatment suspension, T2).