Statistical analysis
Univariate and multiple comparisons statistical analyses were performed using GraphPad Prism, version 8. For comparisons between patient groups, the Mann–Whitney and Wilcoxon signed rank tests were applied and for multiple group comparisons One-Way ANOVA test corrected for multiple comparisons with original False Discovery Rate (FDR) method using Benjamini and Hochberg method, were used. The Spearman and Pearson test were applied for the correlation analysis with non-parametric and parametric data, respectively. For all analyses, p-values <0.05 were considered statistically significant. Principal Component Analysis (PCAs), Heatmaps, Venn diagrams and correlograms were performed with RStudio version 1.2.5042.