Ethics and registration
This study was approved by the Medical Ethics Committee in Affiliated Hospital of Yangzhou University, Jiangsu, China (Protocol/serial number: 2022-YKL3-08–002) on 8 March 2022. All study subjects gave informed consent for all treatments and investigations. All procedures in the study involving human participants were performed in accordance with the ethics standards of the institutional and national research committee and with the Helsinki Declaration and its later amendments or comparable ethics standards. The study was conducted and reported in accordance with the Consolidating Standards of Reporting Trials (CONSORT) 2010 statement. This trial was registered at the Chinese Clinical Trial Registry (