Study design and patients
This multicenter, prospective, randomized controlled study was conducted between June 2021 and December 2021. Four centers located in different regions of China were included in this study: the Second Affiliated Hospital of Xi’an Jiaotong University, the Second Affiliated Hospital Zhejiang University School of Medicine, the Peking University Third Hospital, and the Nanfang Hospital Southern Medical University. The study was approved by the Ethics Committee of the second affiliated Hospital of Xi’an Jiaotong University (Permit Number: XJTU 2021-015). The trial is designed as a randomized controlled study (Trial Number, ChiCTR2200065786). The study protocol and ethics approval are available on this website (