Conflict of interest
H.Y. received consulting and lecture fees from Bayer Yakuhin, Ltd., Kyowa Kirin Co Ltd., and Astellas Pharma Inc. during the study. T.Y., K.M., T.Y., T. K., K.O., and Y.N. are employees of Bayer Yakuhin, Ltd. T.A. received consulting and lecture fees from Bayer Yakuhin, Japan Tobacco, Astellas Pharma Inc., GlaxoSmithKline, Torii Pharmaceutical, Kyowa Kirin Co Ltd, Kissei, Mitsubishi Tanabe, and Chugai during the study.