Subtypes of APA identified by somatic genotype and IHC
CYP11B2-expressing adenomas
Genotyping was performed in 70 CYP11B2-expressing adenomas. Bulk RNA sequencing (RNA-seq) of APAs and the paired adjacent adrenal tissue allowed the detection of known somatic driver mutations in most samples (Supplementary Table Overall, the numbers of The expression of CYP11B2 was slightly lower, and CYP11B1 substantially higher, in RNA-seq enabled whole transcriptomes and genotypes to be directly correlated in the same samples and the results are shown for 200 genes that were the most upregulated in APAs (by at least 2.5-fold) compared with the adjacent adrenal. The results for all 200 genes are shown in Extended Data Fig. The first part of the heatmap (Extended Data Fig. 