Background
infectious diseases, allergic, inflammation, traumatic, pain, Aphthous Stomatitis
INFECTIOUS DISEASES, ORAL LICHENOID REACTION, STILL, MUCOSA DISEASE, INFLAMMATION, DISEASE, ULCERS, APHTHOUS STOMATITIS, CAVITY, MINOR ORAL APHTHOUS ULCER
Recurrent Aphthous Stomatitis (RAS) is a common oral mucosa disease characterized by single or multiple painful and recurrent ulcers confined to the oral cavity. Its prevalence in different populations has been reported to vary from 5 to 50%, with an average prevalence rate of 20% and higher occurrence in young women [There are predisposing factors reported for this disease, such as psychological, hematological, genetic, traumatic, and allergic factors. Still, the etiology of the disease is unknown. So, there is no definitive cure for the disease [Herbal medicines have become prevalent among people because of several health benefits attributed to these natural and safe agents. Herbal medicines are also widely used in dentistry because of their unique properties, including antimicrobial, antifungal, anti-inflammatory, and antioxidant effects [Salvia officinalis (common Sage, culinary Sage) is an aromatic plant often used for different purposes, especially as a traditional medicine for treating several infectious diseases [Salvizan gel is a pharmaceutical product made of Sage extract used to alleviate the inflammation of the oral mucosa. A study in 2021 compared the effects of Salvizan and triamcinolone acetonide gels on the duration and symptoms of oral lichenoid reactions. They reported that Salvizan gel significantly relieved the pain better than triamcinolone acetonide, which is promising for using Salvizan gel in treating oral lesions [Due to the antimicrobial, anti-inflammatory, antifungal, and analgesic effects of Sage, which is used in Salvizan gel, and the lack of evidence in the considered population, the present study aimed to evaluate the effect of Salvizan gel on minor oral aphthous ulcers in comparison to triamcinolone acetonide.