Conclusion
allergy, eczema
ALLERGY, PEANUT ALLERGY, ECZEMA
We demonstrate a significant reduction in PA with early peanut introduction in a large group of pooled, randomized participants. This significant reduction was demonstrated across all risk subgroups, including children with no eczema. Furthermore, our results point to increased efficacy of the intervention with earlier age of introduction.An integrated meta‐analysis employing both LEAP (high risk) and EAT (normal risk) individual patient data shows that early introduction of peanut in infancy prevents the development of peanut allergy regardless of presence or severity of eczema, ethnicity and sensitization to peanut. Earlier introduction of peanut before 6 months of age is more effective than later introduction in the prevention of peanut allergy. Causal inference methods accurately estimated the efficacy of this strategy while addressing the problems of poor adherence in the intention‐to‐treat analyses and biases in the per‐protocol analyses.Abbreviations: EAT, enquiring about tolerance; ITT, intention to treat; LEAP, learning early about allergy; PP, per protocol
Kirsty Logan and Henry T. Bahnson contributed equally to this manuscript.