Impact of chronotherapy on clinical disease activity, quality of life, inflammatory cytokines, and adverse events
TNF-α
ADVERSE EVENTS, ADVERSE EVENT, DISEASE
There was not a significant difference in clinical disease activity or quality-of-life measures with chronotherapy intervention. The mean Inflammatory cytokines TNF-α and IL-6 also did not differ significantly by Adverse events encountered by each participant over the course of intervention period did not differ with change of timing of the medication. Most side effects were mild to moderate and required no intervention. There were no serious adverse events that required participant discontinuation from the study.