Allocation and blinding
wheezing, CTCM
SECONDARY, RECRUITMENT
The wheezing preschool children that participate in the RCT will be randomly assigned (1:1), with a secure computer-generated block randomisation procedure (block size of 6), into a usual care group and an intervention group. The randomisation will be organised by the Clinical Trial Centre Maastricht (CTCM) and MEMIC (centre for data and information management at the Faculty of Health, Medicine and Life Sciences of Maastricht University and MUMC +). Randomisation is stratified per measurement centre. The participants, treating physicians and the researchers or research assistants involved in conducting the baseline visit are not blinded to the results of the randomization procedure. The assessment of the primary outcomes and secondary outcomes after one year and at the end of the study will be done by researches who were not involved in the recruitment and randomization procedures. These researchers will be blinded towards the allocation in randomisation group and (final) diagnosis of the participants.