The research protocol
Headache, headache
Headache frequency was derived from structured headache diaries. The primary endpoint was the achievement of 50% or more reduction in headache frequency at 12 months compared to baseline.Secondary endpoints included variations in the following: headache frequency (change in number of days and percentage change); QoL, assessed by the Migraine-Specific Quality of Life Questionnaire, version 2.1 (MSQ v2.1) [A detailed description of the research protocol is included in Supplementary Methods 1 (see Additional file 