Ethics statement
The studies involving humans were approved by Bioethics Committees of the Andalusian Government (Cadiz, Spain), and the Bioethics and Biosafety Committees of the University of Extremadura (UEX) (Caceres, Spain). The studies were conducted in accordance with the local legislation and institutional requirements. Written informed consent for participation in this study was provided by the participants’ legal guardians/next of kin.