Discussion
postoperative pain, Pain, swelling, pain, trauma
HAND SWELLING, COMPLICATIONS, INFLAMMATORY RESPONSE
The purpose of this study was to evaluate the postoperative effects of PRF in bone healing, wound healing, pain, swelling and periodontal complications outcomes after impacted mandibular third molars extraction. We hypothesized that PRF would enhance bone repair and would modulate the inflammatory response. The specific aims of the present study were 1) to measure differences in bone volume, trabecular thickness and greyscale for the two different treatment groups and 2) to evaluate the efficiency of PRF in terms of swelling reduction, pain and wound healing improvement. The results indicated that the use of PRF in impacted third molar sockets after the extraction significantly improves bone healing on the 90-day postoperative evaluation.Third molar extraction is the most common procedure performed on the clinical routine of Oral Maxillofacial Surgeons (The healing process, swelling, and pain can be affected by several factors, such as surgeon experience, degree of trauma, patient age and gender, and third molar surgery operative time (In the analysis of the modified Landry Index (The application of platelet concentrates following third molar extraction has been described in the literature with promising results (In some clinical trials (Regarding postoperative swelling and pain, the PRF group showed earlier pain and swelling reduction during peak (72 h). This finding agrees with data reported in previous studies (In our study, no periodontal defects adjacent to the second molar were observed in either group. Ritto A previous study (The use of CBCT images enables the analysis of bone structure parameters usually performed in micro-CT or histology (When discussing the limitations of our study, we cannot exclude the possible effects of rescue medication intake on postoperative pain levels. In this study, the patients received oral and written instructions regarding the use of acetaminophen. Pain subjectivity is a complicating factor in the patient’s understanding in regards to the need to take a rescue medication in the postoperative period. Postoperative wound healing evaluation was performed using a modified Landry index (The use of PRF in impacted third molar sockets after the extraction significantly improves bone healing as it exhibits higher trabecular thickness and bone volume on the 90-day postoperative evaluation. PRF reduces postoperative pain and swelling and improves wound healing during the postoperative period. Besides, it does not affect the distal probing depth of the second molar on the 90th day of postoperative period.Ackcnowledgements This study was partly financed by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001. BV is grateful to the ‘Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)’.Authors contributions Éwerton Daniel Rocha Rodrigues, DDS, OMFS, MSc, PhD student: The conception of the study, Surgical Procedures, Text Conceptualization, Final Text Approval.
Andrea dos Anjos Pontual, DDS, PhD: Tomgraphic Analysis, Final Text Approval.
Rômulo Augusto de Paiva Macedo, DDS, OMFS, MSc: Evaluator, Text Conceptualization.
Eduarda Helena Leandro do Nascimento, DDS, MSc, PhD: Evaluator, Text Conceptualization.
Belmiro Cavalcante do Egito Vasconcelos, DDS, PhD, Professor, Chair of ostgraduate: Statistical expert, Final Text Approval.Ethics The study was submitted and approved by the Ethical Committee, under the IRB approval number 08330919.0.0000.5207, and registered on the Brazilian Clinical Trials Registry RBR-64vgjd (REBEC).Conflicts of interest None of the authors is exposed to conflicts of interests, financial or corporate affiliations within the past years.Funding None of the authors received any amount of money or products as funding for this study.