Introduction
malaria, ®
MALARIA, MALARIA
Indoor residual spraying (IRS) is a core intervention for the prevention and control of malaria. It significantly reduces adult mosquito vector densities, thereby disrupting malaria transmission for several months following its application. The largescale implementation of IRS contributed substantially to the elimination of malaria from 37 countries during the Global Malaria Elimination Campaign (1955–1969)Despite its impact, the use of IRS has, unfortunately, declined in malaria endemic African countries in recent years mostly due to concerns about the cost and logistical challenges associated with its implementationThe development and spread of vector resistance to the rather limited number of insecticides that have been used for malaria vector control is well documentedVECTRON™ T500 is a wettable powder IRS formulation of the meta-diamide broflanilide, a new insecticide developed by Mitsui Chemicals Crop & Life Solutions, IncMore recently, community trials have been conducted across Africa to assess the impact of deploying IRS with VECTRON™ T500 on a large-scale for malaria vector control in endemic communities. Here we present results of a large-scale cluster randomised trial that evaluated the entomological efficacy, residual activity, and acceptability of VECTRON™ T500 for indoor residual spraying against pyrethroid-resistant malaria vectors in communities in central Benin, in comparison to Fludora® Fusion, a WHO prequalified IRS clothianidin-based formulation used in previous campaigns in Benin. The trial ran for a total of 24 months in the Za-Kpota District of Benin.