Safety
pneumonia, hyperkalemia
ADVERSE EVENTS, ADVERSE EVENT, PNEUMONIA
The safety profile of AK0529 is shown in Table Adverse event profile of AK0529 compared with placebo.Abbreviations: AEs, adverse events; SAEs, serious adverse events; TEAEs, treatment‐emergent adverse events.One case each of increased aspartate aminotransferase, increased transaminases, hyperkalemia.Two cases of unrelated pneumonia.One case of pneumonia, classified as SAE; one case of elevated transaminase.One case of pneumonia.Shifts evaluation for aspartate aminotransferase and alanine aminotransferase (safety population).Abbreviations: CS, clinically significant; For a subject with multiple shifts with different categories, only the worst shift category was counted, where the hierarchy for shift category was ordered from “Normal to abnormal CS” (worst) to “Abnormal CS to normal” (best). Cochran–Mantel–Haenszel test was used to calculate the Two serious TEAEs (pneumonia) were reported: one of Grade 4