Author contributions
J.C.P., T.L.
RECRUITMENT, RECRUITMENT
J.C.P. and C.L.H. designed the original study, and applied for and achieved CIHR funding; J.C.P. applied for and obtained both Besins’ contribution of drug and placebo and the donation allowing a further year of recruitment. A.C. was the research coordinator responsible for day-to-day study conduct with support from J.C.P. and M.F. She also directly interacted with the statisticians and pharmacy on study assignment, with ethics and wrote the first draft of this study with support from J.C.P. who has written all subsequent drafts. Statistical design was created by J.S. with assistance from T.L. and J.C.P. Recruitment was facilitated by A.C., J.C.P., C.L.H., P.J. and M.F. All authors have provided feedback on this manuscript that is revised with their input and submitted with their approval.