Study population
gastrointestinal diseases, chronic infectious diseases, liver and kidney insufficiency, allergies, diabetic, Diabetes, cardiovascular and cerebrovascular diseases, 6)Leukopenia, T2DM
GASTROINTESTINAL DISEASES, VIRUS, HEART INSUFFICIENCY, ALLERGIES, HEPATITIS C, DIABETES, DISEASES, COMPLICATIONS
We recruited 29 adult T2DM patients, following the diagnostic criteria of the American Diabetes Association (ADA) for T2DM in 2019. We obtained written informed consent from all patients before screening. All patients volunteered to participate in the trial and exhibited good compliance and did not replace diabetic drugs in the study cycle. Patients were excluded if they had other diagnoses: 1) acute and chronic infectious diseases, gastrointestinal diseases, severe heart insufficiency, severe liver and kidney insufficiency, and/or other diseases or complications; 2) other gastrointestinal diseases that may affect drug absorption; 3) pregnant and lactating women; 4) people with allergies; 5) patients who have used other hormone therapy within the past three months; 6)Leukopenia or abnormal granulocytes; 7) cardiovascular and cerebrovascular diseases that first occurred in the past three months; 8) Participants in other clinical trials during the same period; 9) a history of human immunodeficiency virus (HIV) seropositivity after laboratory screening; and 10) hepatitis B virus surface antigen (HBsAg) positive or hepatitis C virus antibody (HCV-Ab) history after laboratory screening. During this period, the research team instructed all participants to maintain their original eating habits before and after the intervention, including total calories, types, diet culture, etc., and to maintain light to moderate physical activity (the same intensity) and avoid heavy physical activity. The study has been approved by the Longhu Hospital, The First Affiliated Hospital of Shantou University Medical College Ethics Committee in Shantou, China(Ethics number:LHLL2019001), and was registered at Chinses Clinical Trial Registry.(Registration number: ChiCTR1900024636).(