Statistical justification of the number of patients to be included
The calculation of the number of participants required is based on a preliminary estimate of the effectiveness of the program, based on the following assumptions: a mean decrease in the JADAS-27 score of 2.7 points, a standard deviation 4.6 points [based on a previous descriptive study conducted on 24 patients at the University Hospital of Besançon (Ten additional patients will be included in a control group (without APA). This group will allow to estimate the “natural” progression of the primary outcome without any APA program (control); Follow-up data (excluding activity assessment) will also be collected on this 10-patient group.Randomization will be performed in a 3:1 (experimental:control) ratio according to the design of the study.The study methodology and statistical analyses are managed by the research methods unit (uMETh) of the clinical investigation center, University Hospital of Besancon.