Acknowledgements
We would like to thank patients and their relatives for participating in the trial. We thank our collaborators in DRUP and TAPUR for sharing their protocol and valuable experience, and for their contributions on trial- and cohort-design. Roche, Pfizer and Merck (CrossRef Funder ID: 10.13039/100009945), GSK, and Incyte reviewed this manuscript for medical accuracy only before journal submission. The authors are fully responsible for the content of this manuscript, and the views and opinions described in the publication reflect solely those of the authors.