Conclusions and Relevance
cancer, weight loss, CVD
CVD, CANCER, EVENTS
This cohort study of healthy older adults suggests that weight loss was associated with an increase in all-cause and cause-specific mortality, including an increased risk of cancer, CVD, and other life-limiting conditions. Physicians should be aware of the significance of weight loss, especially among older men.This cohort study uses data from the Aspirin in Reducing Events in the Elderly clinical trial to examine the associations of changes in body weight and waist circumference with all-cause and cause-specific mortality.