Pharmacological sGC stimulation in RBCs also induces cardioprotection and cGMP release.
hypoxia
HYPOXIA
To verify that pharmacological activation of RBC sGC produce effects similar to those of hypoxia, RBCs from WT and sGC-KO mice were preincubated with the sGC stimulator BAY 41-2272 in combination with the NO donor DEA/NO and the PDE5 inhibitor sildenafil before administration to the isolated heart. Preincubation of RBCs from WT mice resulted in improved recovery of postischemic LVDP, and this effect was blocked by the sGC inhibitor ODQ and was absent when using RBCs from sGC-KO mice (