Pharmacodynamics
SKIN
Skin prick testing was routinely performed before each intravenous dose. In general, the reaction to MOv18 IgE in this test was indistinguishable from the negative diluent control, although a wheal reaction of up to 3 mm was also considered negative (Fig. Free FRα protein was detected at one or more time points (baseline, prior to infusion 4 and at 28-day follow up) in the serum of eight patients, although in the remainder it was undetectable throughout (Supplementary Fig. Analysis of circulating cytokine concentrations in all the treated patients revealed an increase in the mean fold-change serum concentration of IL-6 from baseline, which peaked 4–6 h after dosing and was detectable for up to 7 days (Fig. Alpha-GAL IgE antibodies