Limitations
ADVERSE EVENTS

There were some limitations in this study. Considering Morisky scale as a subjective tool to assess medication adherence, we used pill count method to avoid internal validity threat. This method was used as an objective and supplementary method, considering its practicality and simplicity. Lack of generalizability due to a single site of study was the other limitation. Also lifestyle-related factors with medicine adherence were seldom examined in this study. Larger studies covering wider areas and focusing more on the lifestyle or other risk factors should be carried out in future. Use of a case report form for assessing adverse events in this study was another limitation. Totally self-reported answers may be exaggerated; respondents may be too embarrassed to reveal private details or even forget needed data. Due to neutralize this effect, the investigator compared the answer with their medical records and physician confirmation. The possibility of cross-group contamination also could have affected our study. Although the investigators planned to have even introduction session with each group in different days to avoid participants’ connection.