Noncompartmental Analysis
Pharmacokinetic parameters for giredestrant were calculated from the plasma concentration–time data according to standard noncompartmental analysis methods using Phoenix WinNonlin (version 8.3.4; Certara USA, Inc.). Noncompartmental analyses were conducted in pharmacokinetic-evaluable patients, defined as those having at least one nonzero postdose plasma concentration. Patients with dose reductions, sparse pharmacokinetic samples, incomplete pharmacokinetic profiles, or incorrect dosing information during pharmacokinetic sampling were not included in the noncompartmental analysis.