Results
PD, controlNo
ADVERSE EVENTS
Fifty-five patients were consecutively screened, and 24 of them were enrolled, and 12 allocated to the test and 12 to the control group. All patients attended the 3- and 6-month follow-up visits. Figure CONSORT flow diagram of the studyThe characteristics of the included patients at baseline are listed in Table Characteristics of the enrolled patients at baselineThe baseline mean values for all the clinical outcomes are depicted in Table Baseline values and follow-up changes measured at all treated sites expressed as mean values (standard deviation)Statistically significant differences evaluated by the Mann–Whitney *intra-group statistically significant differencePD reduction was significantly greater in deep pockets as compared to shallow-moderate pockets at 3 and 6 months only in the test group (Table PD reduction for shallow-moderate (initial PD <6 mm) and deep pockets (initial PD ≥ 6 mm) at 3 and 6 months expressed as mean values (standard deviation)Statistically significant differences evaluated by the Mann–Whitney Percentage of closed (PD ≤ 4 mm and BOP-) pockets for all, shallow-moderate (initial PD < 6 mm) and deep (initial PD ≥ 6 mm) pockets in the test and control groups at 3 and 6 monthsStatistically significant differences evaluated by the Fisher exact test. *, statistically significant difference vs. controlNo adverse events were reported, and no significant differences in terms of intraoperative and postoperative discomfort were observed between the groups.Bacterial species levels showed heterogeneous behaviour from baseline to the follow-up visits (Fig. Microbiological results. DNA level of microbial species in test (