1. Introduction
collagen-induced, obese, overweight, platelet aggregation
SECONDARY, OBESE
These authors contributed equally to this work.Tomatoes are known for their numerous health benefits, including antioxidants, anti-cancer, antimicrobial, anti-inflammatory, anti-neurodegenerative, antiplatelet, and cardio-protective properties. However, their potential health benefits in the Mediterranean diet’s popular soffritto remain largely unexplored in scientific research. The objective was to evaluate the effects of soffritto intake on platelet activity, vascular endothelial function, weight, lipid profile, and blood parameters. In a prospective, controlled, randomized two-arm longitudinal cross-over trial, 40 overweight and obese individuals received 100 g/day of soffritto, or a control, for 42 days. The primary outcome was the effect on vascular endothelial function and platelet activity. As exploratory secondary outcomes, anthropometric measures, serum lipid profile, and hemogram profile were measured before and after a 6-week intervention with or without soffritto supplementation. Compared with the control group, soffritto supplementation for six weeks improved collagen-induced (−5.10 ± 3.06%) platelet aggregation (The occurrence of overweight and obesity is persistently rising in both developed and developing countries [Tomato, a staple of the Mediterranean diet, is an important source of antioxidants, mainly carotenoids (such as lycopene), phenolic compounds, and vitamins [Discrepancies in the beneficial health effect of tomato or tomato-based products consumption have been related to the bioavailability of lycopene, as it is higher in tomato paste than in fresh tomatoes [