Microbial contribution to human energy balance
REGRESSION
Given the robust response to our diet intervention by the gut microbiome and host, we sought to determine the quantitative contributions of the gut microbiome to energy balance versus the impact driven solely by food digestibilityThis led us to postulate that the quantitatively important variability in host energy balance could be associated with the repertoire of gut microbes in the colon. To test this, we asked whether the variability in host metabolizable energy on the MBD could be related to a unique microbial signature. To identify those microbial signatures, we derived regression coefficients describing each microbe’s association with the independent variable of host metabolizable energy using MaAsLin2’s compound Poisson regression modelWe next embarked on a series of mathematical modeling runs