Cost-effectiveness Analysis
postamputation
EVENTS, COMPLICATIONS
In the base-case analysis, total health care costs, life expectancy, and QALYs per patient in both groups were simulated over 5 years from the Taiwan health care sector perspective. The cumulative probabilities of patients with healing, uninfected DFU, infected DFU, and postamputation as well as the mean time of staying in the healing health state were computed for each study group. The numbers of healing events and DFU-related complications were estimated through 10 000 times of microsimulation.The incremental cost-effectiveness ratio (ICER) of ON101 with GWC vs GWC alone was the incremental total health care costs divided by the incremental total QALYs. Future costs and health outcomes were discounted at 3% yearly.All study analyses were performed using TreeAge Pro 2020 (TreeAge Software, LLC). The impact inventory for the components considered in economic analyses is provided in eTable 1 in 