Statistical analysis
diabetes mellitus, CKD, hyperkalemia, acute kidney injury
METABOLIC ACIDOSIS, DIABETES MELLITUS, CONGESTIVE HEART FAILURE
Baseline characteristics between the four groups will be compared using Chi-square test for categorical variables or ANOVA with contrasts and Kruskal-Wallis test (non-parametric) for continuous variables. Variables of interest include acute kidney injury, CKD or chronic dialysis status; diabetes mellitus; congestive heart failure; RAAS inhibitor medication prescription; metabolic acidosis; and concurrent therapies for hyperkalemia (insulin/dextrose, diuretics, albuterol, bicarbonate).Linear mixed effects models will be used to compare mean change in blood KSafety and tolerability will be assessed using a Kruskal-Wallis test to globally test for a negative trend across all 4 study treatments (two-sided 