Treatment groups
GROUP B
In total, 90 patients were randomised to 1 of 2 groups. Group A received intravenous TXA 10 min before tourniquet compression (20 mg/kg) and 3, 6 and 24 h later (10 mg/kg); Group B was treated the same as Group A but received intravenous TXA before tourniquet release. The included patients were randomised into Groups A and B in a 1:1 ratio using the random number table method. The random numbers generated were sealed in opaque envelopes and kept by staff who were not involved in the study and did not measure outcomes. Preoperative, intraoperative and postoperative data were collected and recorded by one researcher without the surgeon being involved in the collection. Throughout the study, the surgeon, patient, and data collector and analyst were unaware of the intervention.