3.3. CYP Genotype and Phenotype
Our results showed that there was no association of CBD concentrations of concentration-matched CBD formulation with any phenotype or genotype. An exception was observed only for the concentration of CBD in men after 5 weeks of consumption, and related to the CYP2C9 enzyme phenotype. Men with the NM phenotype had significantly higher values of CBD in urine compared to subjects with IM phenotype. Also, a difference in the CYP2C19 enzyme phenotype was observed among female subjects. Although this was compared to subjects with the RM phenotype, subjects with the NM phenotype had greater values here as well. Perhaps this is the result of the formulation used, which bypasses the first pass through the liver, where the tested enzymes are located. There are also studies that have shown that cannabinoids and their metabolites can inhibit some P450 enzymes [