Study Procedures And Randomization
angina, visual stenosis, ischemia, atrial fibrillation, heart failure
ATRIAL FIBRILLATION, ISCHEMIA, HEART FAILURE
At enrollment, patients ceased antianginal medication. Antihypertensive medications with antianginal properties were replaced with alternatives with no antianginal effects. Medications with antianginal properties required for other clinical indications such as heart failure or atrial fibrillation rate control were continued. Risk reduction medications including dual antiplatelet medication and high-intensity statins were prescribed.Patients were taught to use a dedicated smartphone application for daily angina symptom reporting. The design, features,Patients underwent coronary angiography with auditory isolation using over-the-ear headphones with music playing throughout the procedure. Pre-randomization invasive physiological assessments were performed in each vessel with a ≥50% visual stenosis; operators identified the target vessels for PCI. For randomization, evidence of ischemia was required in at least one cardiac territory. Non-ischemic patients were withdrawn.Eligible patients were administered incremental doses of intravenous benzodiazepines and opiates to achieve a deep level of conscious sedation until they were unresponsive to verbal and tactile stimuli. Patients were then randomized 1:1 to PCI or placebo procedure using computer generated randomization with block size between 8 and 16 and no stratification.