Discussion
obesity, HC
CVD, OBESITY, TYPE 2 DIABETES
This post hoc analysis of the placebo group of the REWIND CV Outcomes Trial showed that the anthropometric measures WHR and/or WC, but not BMI, were risk factors for MACE-3, CVD-related mortality, and all-cause mortality in patients with type 2 diabetes and CV risk factors or established CVD. BMI was a significant risk factor only for HF requiring hospitalization. WHR and/or WC were risk factors for all four outcomes, with varying strengths of associations when analyzed in a combination model with other obesity measures. WC adjusted for HC was one of the strongest risk factors for MACE-3, CVD-related mortality, and all-cause mortality, indicating that both WC and HC have independent information pertaining to CV risk which is not completely captured by WHR.