ACKNOWLEDGEMENTS
We are grateful for the support of the Institut Català de la Salut, especially those from the Gerència Territorial Terres de L’Ebre, including the authorities, health and non-health workers, the Informatic Systems unit, and the patients involved in the study. We are also grateful to the Catalonian Primary Care Services Information System (SISAP) for its data contributions. Furthermore, we thank the Division of Insurance Medicine in Karolinska Institutet (Stockholm, Sweden) for their technical support and academic collaboration. Finally, this work has been carried out within the framework of the doctoral programme in Biomedical Research Methodology and Public Health from the Universitat Autònoma de Barcelona.This study was supported by a grant from the Fundació Doctor Ferran in 2017, by the Instituto de Salud Carlos III (ISCIII) and the European Regional Development Fund with a research grant awarded in 2018 (reference PI1800943), and a predoctoral scholarship granted to VMA in 2019 (reference FI19/00254). The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.The study was conducted in accordance with the Declaration of Helsinki and approved by the Clinical Research Ethics Committee of the IDIAPJGol Institute (codes P17/069 and P18/068 on 25 April 2018). Written informed consent has been obtained from the patients to use their anonymous information for research and publication.ClinicalTrials.gov: NCT04049006, Registered 7 August 2019 – Retrospectively registered (
