Cross over therapy/non-compliance
Patients should not be switched to any other formulation of tacrolimus unless it is for a justified medical reason. In case of interruption or switching of tacrolimus therapy, patients should be returned to the assigned IMP as soon as it is safe to do so. Non-compliance with IMP intake is possible, especially after patients are discharged from the hospital. To optimise patients’ compliance, a compliance check will be done at each site visit, including drug accountability and tacrolimus blood trough level measurements.