Pilot clinical data
The ISPCTN and the NRN have undertaken a retrospective chart review to inform the design of clinical trials for infants with NOWS (ACT NOWS current experience: Infant exposure and treatment). Investigators reviewed medical records for infants ≥ 36 weeks gestational age and born between July 1, 2016, through June 30, 2017, and mothers medical records, when available, when there was opioid use, determined by maternal history, maternal/infant toxicology screen, or NOWS scoring. Data were collected from 1808 infants at 23 of 28 ISPCTN sites and two of five NRN sites.The salient findings from the preliminary data of the ACT NOW Current Experience retrospective chart review were:Of infants evaluated for NOWS, medical professionals treated 38.6% with pharmacologic therapy.Of infants treated with pharmacological therapy, the primary medications to control NOWS signs were morphine (86.1%) and methadone (12.9%).