Conclusions and Relevance
noncolorectal GI cancers, overweight, CRC, Cancer
SECONDARY, OBESE, CARCINOGENESIS, CANCER
In this secondary analysis of the PLCO Cancer Screening Trial, overweight and obese BMI in early and middle adulthood was associated with an elevated risk of CRC and noncolorectal GI cancers. The results of the current study prompt further exploration into the mechanistic role of obese BMI in carcinogenesis.