Conclusions
sepsis, cardiovascular or respiratory support
SEPSIS
In the VICTAS trial, for survivors of sepsis who were treated early with vitamin C, thiamine, and hydrocortisone in the ICU, the cognitive, psychological, and functional outcomes at the 6-month follow-up either were unaffected by the regimen or were worse than for patients who received placebo. These results do not support antioxidant and anti-inflammatory therapy and suggest that antioxidant and anti-inflammatory therapy does not mitigate the development of long-term cognitive, psychological, and functional impairment in patients with sepsis who require cardiovascular or respiratory support in the ICU.