Statistical analysis
SECONDARY
With regard to the statistical analysis, RIAT investigators adhere to the original protocol procedures linked only to primary and secondary prespecified outcomes. A database was created to register and extract data from every endpoint described in the study protocol, including a statistical analysis when needed [Efficacy analyses were prespecified to be conducted using a Missing values were jointly dealt by the sponsor, lead researcher and statistician to decide on the last meaningful data (probably a The final unpublished report was used as the main source of data for all outcomes except the non-preplanned primary outcome and use of acetaminophen, as data for these variables were only available in the article publication.