Increased blood pressure
ADVERSE EVENT
The greatest mean (SD) change in systolic and diastolic blood pressure (BP) from predose values were +9.3 (12.01) mmHg at day 15 and +6.1 (7.84) mmHg at day 25, respectively, in the induction phase and +10.2 (9.25) mmHg at week 184 and +6.0 (6.36) mmHg at week 184, respectively, in the optimization/maintenance phase, all at 40 min post-dose. Participants who met the study criteria for markedly elevated BP (i.e., systolic BP ≥ 180 mmHg or diastolic BP ≥ 110 mmHg) are summarized in the Supplement.Overall, investigators reported an adverse event related to increased BP for 17.9% of participants, with incidence generally similar at visits throughout both the induction and optimization/maintenance phases (Fig. 