Interventions
WS, trisomies
TRISOMIES
Following the completion of the questionnaire, each participant received a session of “traditional counseling”, which included individual counseling and an information sheet for them to read. The individual counseling was face-to-face structured pretest counseling from one of the counseling physicians about the characteristics of common autosomal trisomies, testing options including maternal serum screening, cell-free DNA screening and prenatal diagnosis; and details of cell-free DNA screening. Given genetic counsellor profession did not exist in Thailand, all prenatal genetic counseling in antenatal clinic has been delivered by standardized and trained obstetrics and gynecology residents and maternal–fetal medicine fellows under supervision of the staff, and in some occasion by the staff themselves. Each counseling session took place in an examination room and lasted approximately 10 minutes. All the participants were subsequently given a Thai language information sheet on cell-free DNA screening. The information sheet was developed by maternal–fetal medicine staff (CT, SB, WH, WD, WS), which covered characteristics of common autosomal trisomies, the fetal conditions that can be detected via cell-free DNA screening, the performance and limitations of such screening, the clinical significance of the different screening results, and further management following positive results. The participants were given 10 minutes to read the information sheet in a designated area.After the traditional counseling, the participants in the video group were given a video’s link (Pretest counseling methods in video group (