Conclusion
xerostomia, dryness, dry mouth
XEROSTOMIA, DRY MOUTH
Intraoral administration of 10% trehalose spray improved unstimulated salivary flow rate and pH in xerostomia subjects after radiotherapy for HNC. Equivalent with conventional CMC-based interventions, a trehalose oral spray can effectively relieve dry mouth symptoms in post-radiotherapy xerostomia patients with superior patients’ satisfaction. Thus, trehalose solution spray can be indicated as an alternative therapeutical option to relieve oral dryness and improve the quality of life in HNC patients post radiotherapy.