Changes to trial design
RECRUITMENT
In March of 2020 study recruitment was terminated early. While the PLPL trial was originally designed to run in two cohorts, shutdowns due to COVID-19 necessitated an early termination of recruitment. Prior to this shutdown, we were able to fully complete Cohort 1 of this study in 2019. Thus, this manuscript reflects only data from Cohort 1. We did not collect data from the second cohort once restrictions were eased due to the length of time the study had been paused and the substantive changes in physical activity due to COVID-19 [