Ethical considerations
All samples and data were obtained under protocols approved by the ethics committees of the Medical Faculty of the University of Cologne (22_1262), of the Medical Faculty of the University of Bonn (314/22), of the Medical Faculty of the University of Düsseldorf (2022-2072), of the Medical Faculty of the University of Essen (22-10838-BO), and of the Medical Faculty of the University of Münster (2022-490-b-S). All participants provided written informed consent. This study was registered as a clinical trial (DRKS00029414).