Meaning
depressive disorder, depressive
CORTEX
These findings suggest that DLPFC volumetric and rsFC changes after treatment may represent one set of potential neurobiological treatment markers that are associated with depressive symptom improvement in adolescents with MDD.This cohort study examines neurobiological changes associated with selective serotonin reuptake inhibitor treatment in adolescents in Korea with major depressive disorder by evaluating longitudinal changes in volume and resting-state functional connectivity in the dorsolateral prefrontal cortex.