Participants
MAY
Between September 14, 2020, and May 9, 2021, a total of 321 healthy men were screened, and 70 eligible subjects were enrolled. Of these, 56 subjects were randomly assigned to receive SHR7280 (eight subjects for each dose), and 14 were assigned to receive placebo. Two subjects in the SHR7280 group (one in the 500 mg group and one in the 1000 mg group) discontinued the treatment due to subject decision. The remaining 68 subjects completed the assigned study treatment. Baseline characteristics were well-balanced across different doses of SHR7280 and the placebo group (Table Baseline characteristicsData are mean (SD)