Statistical Modeling of the Primary and Secondary Outcomes
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REGRESSION
To assess the effect of cognitive training on the outcomes at each time point (baseline and after finishing training at 6 months [±2 months] and 16 months [±2 months]), a mixed model for repeated measures was performed for each outcome. We systematically adjusted for confounding by including the following confounders in the mixed regression model: neurodevelopmental profile severity (for 3 subtests of NEPSY, 2nd EditionAn additional sensitivity analysis using the previous mixed model was conducted for participants who completed at least 15 training sessions by recommendations of the cognitive training program to assess the conclusions’ robustness. When appropriate, 95% CIs were presented. The α level of significance was set at 5%; hence, 2-sided Another sensitivity analysis was conducted for participants who completed at least 20 or 25 cognitive training program sessions. Data were analyzed from February to December 2020 using IBM SPSS Statistics for Windows, version 20.0. The statistical analysis plan is available in 