Baseline evaluations
Potential participants are identified at NHS hospital trusts in the UK and invited to a baseline visit. After informed consent, participants undergo assessment of eligibility criteria, review of medical history and concomitant medications, measurement of vital signs, biochemistry and haematological laboratory investigations, ECG and 24-hour heart monitoring. If eligibility is confirmed, visit 2 is arranged during which a urine sample is collected and participants undergo CMR scanning and cardiopulmonary exercise testing before being randomised.