Primary outcome
guilt, anxiety, loss of appetite, sexual interest, psychomotor retardation, depressive symptoms, depressive, agitation, insomnia, depressed mood, hypochondriasis
DISORDERS
The primary outcome was depressive symptoms assessed by the 17-item version of GRID-HAMD at 21 weeks. We used GRID-HAMD because it assesses not only depressive symptoms (i.e. depressed mood, guilt, suicide, insomnia, difficulties in work and activities, psychomotor retardation or agitation, loss of appetite, sexual interest, weight, or insight) but also anxiety-related symptoms (i.e. psychic and somatic anxiety, general somatic symptoms, and hypochondriasis), which reflect common emotional symptoms across depressive and anxiety disorders (range: 0–52). The GRID-HAMD has been reported to exhibit excellent inter-rater reliability with an intraclass correlation coefficient of 0.95–0.99 and acceptable internal consistency as shown by a Cronbach's alpha of 0.78 (Williams et al., 