Duration
DISEASE, RECRUITMENT
It is expected that recruitment to stage I will complete in approximately 12 months. Analysis of disease control will be performed at approximately 6 months from completion of stage I recruitment. As the results of stage I will inform which arms are included in stage II, during this time randomisations will be paused. It is then expected that recruitment to stage II will complete in a further 12 months. Analysis of disease control will be performed within 12 months of recruitment completion.