Participants
pelvic infection, epilepsy, drug allergies, bronchitis, asthma, glaucoma, abortion, schizophrenia, sepsis
PELVIC INFECTION, VAGINAL BLEEDING, LUNG DISEASE, MITRAL STENOSIS, HEART DISEASE, EPILEPSY, DRUG ALLERGIES, IRREGULAR UTERINE CONTRACTIONS, DISORDERS, LIVER DISEASE, ACUTE HEPATITIS, BRONCHITIS, ECTOPIC PREGNANCY, ASTHMA, GLAUCOMA, SEVERE ANEMIA, SEPSIS, BLEEDING DISORDERS
Inclusion criteria included (a) Iranian nationality; (b) ≥ 18 years of age; (c) gestational age from 12 to 20 weeks; (d) having a single fetus according to ultrasound confirmation; (e) initial Bishop score less than four; (f) body mass index (BMI) less than 30; and (g) indication of termination of pregnancy due to IUFD with confirmation in two ultrasounds.Exclusion criteria included (a) drugs abuse; (b) smoking more than ten cigarettes a day; (c) history of cesarean section; (d) contraindications of misoprostol including ectopic pregnancy, symptoms of pelvic infection or sepsis, unstable hemodynamic status, mitral stenosis, glaucoma, asthma, and bronchitis; (e) contraindications of EPO including a history of mental illness with taking phenothiazine, history of epilepsy, schizophrenia, history of bleeding disorders and use of anticoagulants; (f) medical disorders such as heart disease, lung disease, active liver disease, acute hepatitis; (g) contraindications of misoprostol/EPO include previously known drug allergies to them, having regular uterine contractions, severe anemia, and severe vaginal bleeding.The withdrawal criteria included (a) women with drug allergies to misoprostol or EPO; (b) women with abnormal hemodynamic status during the study; (c) Failure to expel the fetus by receiving five doses of misoprostol and 20 h passed (d) need for catheterization during the abortion process, and (e) unwillingness to continue the study.