Ethics approval and consent to participate
This prospective randomized controlled clinical study was carried out on patients scheduled for lower limb orthopedic surgeries at Zagazig University hospitals. The first patient was enrolled on October 1, 2021, after ethical approval from the institutional review board (The research ethics committee of Faculty of Medicine, Zagazig University) with the reference number (ZU-IRB#7045-15-8-2021). This study was registered under clinicaltrials.gov (NCT05041270) on registration date 13/09/2021. Written informed consent was obtained from all participants after they understood the concept of this research. The study was carried out in accordance with the guidelines and regulations of the Helsinki Declarations.