Randomization and blinding
BLIND
After eligibility screening, patients were randomly assigned in a 1:1:1 ratio by centralized randomized grouping, the dosing investigator logged into the randomization system (block of size of 6), and obtained the randomization number, the randomization number generated by SPSS 25.0 software was used as the blind codes to number the study drugs and imported into the centralized randomization grouping system of Sichuan Provincial People’s Hospital, drugs were distributed according to the randomization number.Considering the large difference in the appearance of the trial drugs, remimazolam tosylate (powder) and propofol (emulsion), independent dosing investigators and evaluation investigators were established for this study. The entire trial was blinded to the subjects, but also the evaluation investigator, endoscopist and statistical analysts. The dosing investigator was only involved in the randomization, dosing, and administration process, while the evaluation of the efficacy and safety of the patients and the unscheduled visits were done by the evaluation investigator.