3. Results
caries lesions, caries
CARIES
Overall, 16,719 dental surfaces from 180 kids were included in this study. The CONSORT flow-chart is displayed in The calibration procedure was successfully performed. The level of agreement overall ranged from 90.44% for caries lesions at enamel level (ICDAS 2) to 94.50% for caries lesions at deep dentinal level (ICDAS 6). The Cohen’s kappa regarding the intra-examiners’ reliability ranged from 0.71 to 0.79.The distribution of the surfaces by caries status recorded using the ICDAS and the distribution of the subjects by CTNI are displayed in At baseline, the percentage of surfaces with no caries lesions and surfaces affected were in statistically significant association among the three groups (χThe changes of the CTNI approach during the trial in the three experimental management groups (The Kaplan–Meier survival curves underline statistically significant differences (Breslow estimator No gender or age difference was observed between groups.The multivariate analysis (Cox-Regression) underlines a significant reduction in the risk rate of caries change in the APF in the toothbrush group; the status was highlighted (HR = 0.51 95%CI = 0.33/0.81). Sex and gender were not statistically significantly associated to caries increment. 