Safety
hand-foot, ANL, diarrhea, fatigue, major adverse reactions, hypertension
ADVERSE REACTIONS, ADVERSE EFFECTS, HYPERTENSION, EVENTS, HYPERTENSION
The most frequent adverse effects (AEs) were hypertension and fatigue. Hypertension, hand-foot skin, and diarrhea were among the grade 3 treatment-related AEs that occurred in 7 (15.9%) of the patients. Most of these events can be reversed by adjusting the dose of ANL or by taking other drugs (such as antihypertensive drugs). In the ANL group, 4 patients reduced the dose of ANL due to grade 3 or 4 adverse reactions. In the ANL+S-1 group, 3 patients reduced the dose of ANL due to grade 3 or 4 adverse reactions. There were no treatment-related fatalities. The treatment-related AEs did not interrupt the study. Incidence and grade of major adverse reactions in the ANL group and ANL+ S-1 groupThe comparison of adverse reactions was the comparison of any grade data between the ANL and ANL+S-1 groups.ALT = alanine transaminase; ANL = anlotinib