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neurodegeneration, MAPT, Alzheimer’s disease, cognitive and functional decline, AD
NEURODEGENERATION, PROGRESSIVE NEURODEGENERATIVE DISORDER
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive and functional decline resulting in substantial disabilityGrowing evidence suggests that aggregated, hyperphosphorylated tau may be a key driver of neurodegeneration in AD. Tau protein is encoded by the microtubule-associated protein tau (MAPTIn this study, we aimed to evaluate the safety and pharmacokinetics (PK) of MAPT