Introduction
OSCC, OPMDs, cancers, traumatic
CANCERS, OPMDS, DISORDERS, ORAL SQUAMOUS CELL CARCINOMA, COLD, MALIGNANT DISEASE
Oral potentially malignant disorders (OPMDs) are the most clinically relevant precursor lesions of the oral squamous cell carcinoma (OSCC). OSCC is one of the 15 most common cancers worldwide [The diagnosis and therapy of clinically relevant precursor lesions of the oral squamous cell carcinoma is one of the main parts of prevention of this malignant disease. Targeted therapy is one of the main challenges concerning an oncologically safe tissue removal without overwhelming functional and aesthetic impairment. Compared to the more invasive and bloody cold blade removal with scalpel, the 445-nm semiconductor laser could be a new functional less traumatic tool in the therapy of OPMDs.Laser devices of a respective wavelength are able to cut or ablate tissue with synchronous hemostasis. Many interaction effects with the tissue have been described such as thermal, photochemical, or ablative effects [Surgical devices with CO2 and Nd:YAG (neodymium-doped yttrium aluminum garnet) lasers have already been described for soft tissue dental surgery procedures [For oral applications recently, a 445-nm semiconductor laser device was introduced [The reduced energy absorption in surrounding tissues from scattering may lead to less thermal side effects and promote better wound healing. Thus, the 445-nm laser technology should provide an auspicious instrument for a variety of applications such as surgical incision and ablative tissue surgery. Blue laser may offer a bloodless and clean cutting option with only few side effects in adjacent tissues basing on its special absorption properties [However, there is no study that analyzed the effects of ablative tissue surgery in a randomized controlled trial. Furthermore, there is no extensive information about blue light laser cutting properties so far. Therefore, the aim of the present study was to establish and evaluate the short-term effects of laser coagulation of OPMDs with a novel 445-nm semiconductor laser, examining the assumption of a blue light laser being more effective and comfortable than conventional cold steel excision without increasing side effects.