Methods
liver dysfunction, loss of consciousness, hypotension
CARDIOVASCULAR DISEASE, INTESTINAL OBSTRUCTION, DRUG HYPERSENSITIVITY, NEUROLOGICAL DISORDER, LIPID METABOLISM DISORDER
This study was reviewed and approved by the Ethics Committee of the Tokushima University Hospital (approval no. 4101). The protocol was registered at the University Hospital Medical Information Network Clinical Trial Registry (UMIN-CTR, UMIN000045612). Prior written informed consents were obtained from all participants. The study complies with the CONSORT statement.We included 40 patients aged 45–80 years with the American Society of Anesthesiologists Physical Status 1–2 and who underwent surgery under general anesthesia at the Tokushima University Hospital. We excluded patients with the following characteristics: emergency cases, cardiovascular disease, pregnant woman, severe liver dysfunction, dialysis, neurological disorder, intestinal obstruction, drug hypersensitivity, severe lipid metabolism disorder, body mass index ≥ 30 kg/mPatients were randomly assigned to the remimazolam or propofol group (The primary outcome measure was the maximum change in MAP after induction of anesthesia. Secondary outcome measures were the maximum change in heart rate (HR), CO, and SV. These hemodynamic changes were also examined after adjusting the time until loss of consciousness. Frequency of hypotension (MAP < 65 mmHg over 2.5 min) was also compared. The observation period was from induction of anesthesia to 10 min after endotracheal intubation. Figure The research protocol. TCI, target-controlled infusion; LoC, loss of consciousness