Internal prediction model and 
The performance of the internal prediction model (full model presented in the supplement) was adequate regarding both discrimination (AUROC 0.73, 95% CI 0.68–0.77) and calibration (Figure The median predicted risks of mortality were 35.5% (12 mg) versus 34.6% (6 mg) with mean predicted probabilities of 38.5% (12 mg) versus 37.6% (6 mg), respectively, while actual mortality rates were 32.0% (12 mg) versus 37.7% (6 mg) (Table The expected outcomes according to predicted mortality risk for both days alive without life support and mortality at Day 90 are presented in Figure Days alive without life support and mortality Day 90 according to treatment allocation and predicted mortality risk. Expected mean number of days alive without life support (DAWOLS) and risk of mortality at Day 90 with 95% confidence intervals according to the predicted risks of mortality at Day 90 using the internal prediction model. For DAWOLS, predicted values and 95% confidence intervals are truncated at the lowest/highest possible values (0/90 days). 