Population
sepsis, pneumonia, infections, ARDS
SEPSIS, ARDS, PNEUMONIA, INFECTIONS
Of the 745 subjects enrolled in SAILS, 678 subjects had sufficient plasma samples available to obtain baseline total cholesterol levels, and thus were included in this analysis. In the SAILS trial, the predominant cause of sepsis-associated ARDS was pneumonia, with the remaining cases largely consisting of other infections and aspiration. Median total cholesterol was low in this cohort, 97 mg/dL (IQR 69–130), with the lowest quartile defined by total cholesterol < 69 mg/dL.Our analysis of the HARP-2 cohort included 509 subjects from whom cholesterol levels were attainable, including 384 subjects with sepsis. The most common etiologies of ARDS in the entire cohort were identified as pneumonia and sepsis. Median total cholesterol levels for all patients in HARP-2 were also low, 97 mg/dL (IQR 44–168), with the lowest quartile defined by total cholesterol < 44 mg/dL. These values were not significantly different when calculated for all 509 HARP2 subjects versus only the 384 with sepsis (data not shown).