Conclusions
MCI
The SYNERGIC Trial demonstrated that a multidomain intervention of progressive aerobic-resistance exercises with sequential cognitive training can improve global cognition, including memory, attention, word recognition, and orientation in older adults with MCI, as measured by one of our primary outcomes, the ADAS-Cog-13. The multidomain intervention effect was larger than the improvement from exercise alone. Vitamin D supplementation had no significant benefit. Our findings suggest that this multidomain intervention could induce a clinically meaningful cognitive improvement in individuals with MCI, which may have important implications for their quality of life.