Cardiac Magnetic Resonance Imaging, Doppler Echocardiography, 24-Hour Blood Pressure, and Natriuretic Peptide Outcome Measures
PHYSICAL DISABILITY
Abbreviations: BNP, B-type natriuretic peptide; bpm, beats per minute; DBP, diastolic blood pressure; E/e′, the ratio between early mitral inflow velocity (E) and mitral annular early diastolic velocity (e′); LA, left atrium; LV, left ventricle; PP, pulse pressure; SBP, systolic blood pressure.Among patients randomized to sacubitril/valsartan, 6 did not attend for baseline cardiac magnetic resonance imaging (MRI; 1 was found to have recent surgery clips contraindicating MRI, 1 had a physical disability, and 4 refused for personal reasons) and 23 did not attend follow-up (4 were lost to follow-up, 2 died, 1 had a prolonged medical admission, and 16 refused for personal reasons, including concerns about attending due to COVID-19). Among those randomized to valsartan, 9 did not attend for baseline cardiac MRI (all refused for personal reasons) and 24 did not attend follow-up (5 were lost to follow-up, 3 died, 1 had a non-MRI compatible pacemaker inserted, and 15 for personal reasons). Differences in LV and LA absolute numbers relate to incomplete left atrial acquisitions.Within-group change, Within-group change, Within-group change, 