References
Anxiety, anxiety, depressive disorder, depressive, MetS, metabolic syndrome, depression, Depression, TG, dysthymic disorder
DISORDER, METABOLIC SYNDROME, INFLAMMATION
Participant flow diagram. MetS: metabolic syndrome; PRO-DMS: probiotic + depression + MetS group; PRO-D: probiotic + depression group; PLC-DMS: placebo + depression + MetS group; PLC-D: placebo + depression group.General characteristics of the study participants at the start of the trial.F: females; M: males; 6A70: single episode depressive disorder; 6A71: recurrent depressive disorder; 6A72: dysthymic disorder; 6A73: mixed depressive and anxiety disorder; BMI: body mass index; MetS: metabolic syndrome; TG: triglycerides; HDL-c: high-density lipoproteins cholesterol; BP: blood pressure; fGlc: fasting glucose.Dietary intakes of study participants at the beginning of the study according to Food Frequency Questionnaire-6.Food frequency intake assessed in a scale 1–6: 1—never or almost never; 2—once a month; 3—several times a month; 4—several times a week; 5—every day; 6—several times a day.Psychometric scores of the study participants at the beginning of the study.MADRS: Montgomery–Åsberg Depression Rating Scale; DASS: Depression, Anxiety and Stress Scale; QoL: quality of life.Metabolic parameters of the study participants at the beginning of the study.BMI: body mass index; WC: waist circumference; sBP: systolic blood pressure; dBP: diastolic blood pressure; fGlc: fasting glucose; HDL-c: high-density lipoprotein cholesterol; TG: triglicerides; AST: aspartate aminotransferase; ALT: alanine aminotransferase; APRI: AST/PLT ratio index; FIB-4: Fibrosis-4; *: metabolic syndrome criteria components.Inflammation parameters of the study participants at the beginning of the study.CRP: C-reactive protein; WBC: white blood cells; NEU: neutrophils; LYM: lymphocytes; PLT: platelets; SII: systemic inflammatory index.Change in psychometric scores of the study participants.PRO-DMS: probiotic + depression + MetS group; PRO-D: probiotic + depression group; PLC-DMS: placebo + depression + MetS group; PLC-D: placebo + depression group; MADRS: Montgomery–Åsberg Depression Rating Scale; DASS: Depression, Anxiety and Stress Scale; QoL: quality of life.The values of metabolic health-related parameters at the beginning (V1) and the end (V2) of the pilot study. PRO-DMS: probiotic + depression + MetS group; PRO-D: probiotic + depression group; PLC-DMS: placebo + depression + MetS group; PLC-D: placebo + depression group.PRO-DMS: probiotic + depression + MetS group; PRO-D: probiotic + depression group; PLC-DMS: placebo + depression + MetS group; PLC-D: placebo + depression group; BMI: body mass index; WC: waist circumference; sBP: systolic blood pressure; dBP: diastolic blood pressure; fGlc: fasting glucose; HDL-c: high-density lipoprotein cholesterol; TG: triglycerides; AST: aspartate aminotransferase; ALT: alanine aminotransferase; APRI: AST/PLT ratio index; FIB-4: Fibrosis-4.The values of inflammation-related parameters at the beginning (V1) and the end (V2) of the pilot study.PRO-DMS: probiotic + depression + MetS group; PRO-D: probiotic + depression group; PLC-DMS: placebo + depression + MetS group; PLC-D: placebo + depression group; CRP: C-reactive protein; WBC: white blood cells; NEU: neutrophils; LYM: lymphocytes; PLT: platelets; SII: systemic inflammatory index.