Discussion
TEAEs
ADVERSE EFFECTS, SECONDARY
To the best of our knowledge, this is the first randomized clinical trial to investigate the efficacy of VPZ in combination with low- or high-dose amoxicillin for 14 days as a first-line treatment of VPZ is a member of a new class of acid-suppressing agents that inhibit the enzyme by reversible KThe primary and secondary resistance rates to clarithromycin are now above alarming levels (>15%) worldwide (China has a high resistance rate to antibiotics (Furthermore, we found no factors that might influence the efficacy of VA dual therapy, including gender, age, body mass index, education status, cigarette smoking, alcohol drinking, family-based In our study, only one patient in each group took <80% of the study drug; therefore, the compliance of the L-VA and H-VA groups was good. Only 29.1% of patients in the L-VA group and 20.0% of patients in the H-VA group reported TEAEs (with no serious TEAEs), indicating that 14-day VA dual therapy is associated with low adverse effects and good safety. Our previous study (There were some limitations in this study. First, the sample size was limited to 110 patients all from one center. Further centers with larger samples, different amoxicillin resistance rates, and different races are needed. Second, the efficacy of 14-day L-VA and H-VA in In conclusion, 14-day L-VA and H-VA provide high efficacy, low adverse effects, and good safety as first-line treatments of 