Overview and Patients
MDD, Depression
Data were from 1008 adults with MDD who participated in the International Study to Predict Optimized Treatment in Depression (iSPOT-D)Patients were assessed on cognitive testing, symptoms, functional capacity, and functional neuroimaging at baseline, randomized in a 1:1:1 ratio to 1 of 3 widely prescribed antidepressants—escitalopram (336 patients), sertraline (336 patients), or venlafaxine-XR