The importance of prefrontal brain dynamics in determining inhibitory control
As shown earlier, post performance was strongly correlated with pre performance, but the strength of this relationship decreased with increasing levels of intoxication (Fig. Lateralization metrics improved the prediction of behavioral performance in addition to measured BAC. (To tease apart the contribution of different parameters to post behavior, we used an Ordinary Least Squares (OLS) approach (“Next, we wondered whether the addition of the lateralization metrics, namely the direction and angle metrics, would improve our model performance in explaining behavior. As such, two additional models were considered in which the direction metric and angle metric were added to the BAC model independently (“We repeated the above analysis while considering only sessions that involved alcohol consumption (i.e. low and moderate) doses. The motivation to perform this analysis was to ensure that placebo sessions were not driving the model performance and diluting the importance of alcohol-related features. Namely, when considering all dosing sessions, including placebo, the distribution of BACs contains an over representation of 0.00 (one-third of the sessions). Therefore, considering only dosing sessions provides a mathematically sound and fairer comparison of the effect of BAC and lateralization metrics on inhibitory control. When comparing the performance of the different OLS models on alcohol-only sessions, we observed that the lateralization metrics (i.e. the direction and angle metrics) performed comparable to BAC in terms of feature importance. The improvement in model performance by the addition of the lateralization metrics was even more pronounced when considering only alcohol sessions (Fig. Taken together, these analyses suggest that the brain lateralization metrics provide complementary information to the legal gold standard of intoxication (i.e. BAC), and may offer more robust predictive power, when considering behavioral performance during inhibitory control. Following suit, the brain-behavior relationship as well as the above-mentioned descriptive model–when redone with 850 nm mean moment–matched these results (Supplementary Fig. 