MAD
Plasma concentration–time profiles overlaid for each dose group of the MAD cohorts are in Figure Overlaid mean plasma KCL‐286 concentration Summary of pharmacokinetic parameters (PK set)—multiple ascending dose.Abbreviations: Ae, KCL‐286 excreted unchanged in a collection period; AeData show mean and standard deviation in brackets.Mean exposure for the highest dose 100 mg, on Day 1 (mean CThese reductions in exposure from Day 1 to Day 7 were observed at all doses. Variability in exposure between participants for the MAD cohorts on Day 1 was low‐moderate (CVs of 16.6–41.4% for CUrine PK concentration–time profiles are presented in Table 