2.5. Canonical Correlation
PCT, SEPTIC SHOCK
A canonical correlation analysis was conducted. It included clinical variables such as SOFA score, PCT PCR laboratory, and oxidant stress biomarkers, and considered explanatory variables (u1, u2, u3) and effect variables (v1, v2, v3).The first evaluation of the canonical correlation carried out was with laboratory parameters and biomarkers. We included the explanatory variables and those of possible effect (cytocines). We found that in patients with septic shock, there is a high correlation of 0.95 when there are high levels of procalcitonin and carbonylation and low levels of total antioxidant capacity (TAC), glutathione, and vitamin C. This correlates with low levels of IL4 and elevated levels of IP10, IL1B, MCP1, IL-6, IL-17, and TNFα.In the second evaluation of the canonical correlation, we found a correlation of 0.86 when there are high levels of LPO, carbonylation, and low levels of GSH, selenium, and thiols; this correlates with low levels of IL-4, il12p70, and IFNy and high levels of IL1B, mcp1, and IL-6. There was a high correlation of 0.82 (although lower than the two previous correlations) which shows us that high levels of the SOFA score, CRP, and CRP, and low levels of GSH and GSH peroxidase correlate with low levels of IL-4, TGFB1, and Il12p70 and high levels of IL1B and IL8 (