Statistical methods
SECONDARY
No data on changes in BMD over time of the 1/3 distal radius were available in patients on dialysis when the study was planned. The sample size calculation was therefore based on cross-sectional data in which a difference in BMD of the 1/3 distal radius of 0.26 g/cmDue to severe heteroscedasticity in the MK-7 group, the variance of residuals at follow-up measurements was allowed to differ from residual variances at baseline. All analyses were repeated with adjustments for age and sex (partly adjusted) and adjustments for sex, age and baseline measures of 25-hydroxyvitamin D and dp-ucMGP (fully adjusted). The testing of secondary endpoints was not hierarchical. Mixed effects models were implemented in Stata version 16 (StataCorp, College Station, TX, USA) and other data processing and analyses using SPSS version 26 (IBM, Armonk, NY, USA). 