Treatment exposure and response
Figure Treatment exposure and duration of response: “On treatment” indicates patients were receiving tirabrutinib. “Off treatment” indicates patients had stopped administration of tirabrutinib but were being followed up in the study. Cohort 1: 160 mg QD; Cohort 2: 320 mg QD; Cohort 3: 480 mg QD; Cohort 4: 300 mg BID. 