1. Introduction
Type 2 diabetes, T2D, hyperglycemia, hypoglycemic, metabolic and chronic disease
HYPERGLYCEMIA, TYPE 2 DIABETES, OXIDATIVE STRESS, COMPLICATIONS
Type 2 diabetes (T2D) affects a large part of the adult population and impairs its quality of life. Because of this, natural compounds with antioxidant, anti-inflammatory and hypoglycemic properties have been used as adjuvants. Among these compounds, resveratrol (RV) stands out, a polyphenol that has been studied in several clinical trials, the results of which are controversial. We conducted a randomized clinical trial on 97 older adults with T2D to evaluate the effect of RV on oxidative stress markers and sirtuin 1, using doses of 1000 mg/day (EG1000, Type 2 diabetes (T2D) is a metabolic and chronic disease that arises due to inefficiency in the body in the use and/or production of insulin, whose hormone is involved in glucose metabolism, which triggers hyperglycemia [In this context, alternative therapeutic options have been proposed to attenuate oxidative damage and thereby delay the onset of T2D complications. In this sense, one of the most widely used is resveratrol (RV), a compound from the stilbenes family that, due to its polyphenolic nature, is capable of donating electrons to FR and ROS, which is why it is considered a powerful antioxidant [