The effect of treatment on different types of RAS
ulcer
MINOR, ULCER
Of the 86 subjects who completed the clinical trial, 46 had minor and 40 had major RAS. The response to treatment in these two subgroups showed a similar trend to that noted in the series, with the mean USS progressively decreasing in both groups over 9 months but with no further significant improvement after 12 months (Fig. Furthermore, variation was noted within the groups, as most patients showed a steady decline in ulcer severity over time, while others showed a rapid improvement but then relapsed. In most patients, little improvement was found beyond 6 months therapy. Moreover, two cases of minor RAS and two cases of major RAS appeared recalcitrant to treatment.
Comparison of the sequential response to treatment in the three study groups. 