Study design
SECONDARY
This study was a randomized controlled clinical trial in a single centre and was performed at the Department of Dental Implantology, College & Hospital of Stomatology, Anhui Medical University (Hefei, China) from December 2020 to December 2021. The primary aim was to investigate the histomorphometry of new bone, and the secondary aim was to assess the dimensional changes of alveolar bone at extraction sites. All procedures and materials were approved by the Medical Ethical Committee of Stomatology Hospital Affiliated with Anhui Medical University (No. T2020011). All the participants agreed to our treatment plan and signed informed consent before the operation. The manuscript was prepared according to CONSORT guidelines, and the clinical trial was registered on the Chinese Clinical Trial Registry Platform.The sample size was calculated for alveolar ridge reduction as reported by a meta-analysis of alveolar ridge preservation, that is, 3.5 mm resorption in height in the control group and 2 mm in the ARP group. The standard deviation between the two groups was 1.08 mm [