Study population
endo-perio, periodontitis, cancer
PERIODONTITIS, CANCER, DIABETES MELLITUS, PERIODONTAL DISEASE, DISEASES
All included patients were referred by their general dentists to the Department of Oral Medicine and Periodontology, University Dental Clinic of Ljubljana, Slovenia, for periodontal assessment and treatment. Between March 2019 and November 2021, 20 male or female participants were explicitly selected as participants in this study of 207 consecutively evaluated individuals.Age 18 to 70 years, stage III periodontitis (grade B/C according to the AAP/EFP classification 2018), presence of 20 teeth for stable occlusion (excluding third molars), and equally distributed periodontal pockets on both sides of the jaw and between molar and non-molar teeth, with at least 9 non-molars in the upper arch, were the inclusion criteria. Exclusion criteria included the following: periodontal treatment in the last 12 months, the presence of prosthetic restorations, implants, endo-perio lesions, pregnancy, lactation, and systemic medical conditions that could affect the progression of periodontal disease or healing (i.e. HIV/AIDS, cancer, diabetes mellitus, diseases of bone metabolism, radiation therapy, chemotherapy, immunosuppressive therapy, antiepileptics, calcium antagonists, and nonsteroidal anti-inflammatory drugs). Less than 10 cigarettes smoked per day was not considered an exclusion criterion.