References
Dermatitis, psoriasis, keratoderma, non-skin, DSAP
DERMATITIS, DISSEMINATED SUPERFICIAL ACTINIC POROKERATOSIS, PSORIASIS, SKIN CONDITION, SKIN CONDITIONS
CONSORT flow diagram of participants with inflammatory skin conditions.Dietary differences observed at baseline between participants with a skin condition (Differences in dietary intake observed at T2 between those with skin conditions (Differences in dietary intake observed at T3 between those with skin conditions (Dissimilarities between skin cohort and non-skin cohort at baseline determined by SIMPER analysis.Data presented as percentage abundance. Different letters denote a significant difference between the genera individually between skin and non-skin groups determined by a Wilcoxon signed-rank test, significance determined by Baseline demographics by treatment regime groups.Data are presented as number and % for gender, mean ± standard deviation or median (25th and 75th percentile). SXRG84, sulfated xylorhamnoglucuronan; BMI, body mass index; PPK, palmar plantar keratoderma; DSAP, disseminated superficial actinic porokeratosis; PPP, palmar plantar psoriasis; PASI, psoriasis area severity index; VAS, visual analogue scale; DQLI, dermatology quality of life index. * Those presenting with an undiagnosed inflammatory skin condition were classed generally as Dermatitis Changes from the baseline at 6 weeks and 12 weeks after placebo or SXRG84 treatment.Data are presented as mean ± standard deviation or median (25th and 75th percentile). AA = Placebo for 6 weeks; AB = Placebo for 6 weeks then SXRG84 treatment for 6 weeks; BB = SXRG84 treatment for 6 weeks; BA = SXRG84 treatment for 6 weeks then placebo for 6 weeks. Change determined by median post value (6 or 12 weeks) minus median baseline value; * Skin conditions that responded to SXRG84 intervention.PPK, palmar plantar keratoderma; DSAP, disseminated superficial actinic porokeratosis; PPP, palmar plantar psoriasis.ANCOVA analysis of responders vs. non-responders after SXRG84 treatment.Data presented as mean difference (standard error).Significant Spearman correlations at baseline between skin measures and gut microbiota genera.Groups used for ANCOVA analysis.