Ethics approval and consent to participate
This study was approved by the Institutional Review Board of Seoul National University Hospital (Seoul, Republic of Korea, Approval number: 1712-125-909) and registered at ClinicalTrials.gov (NCT03505112, Date of registration: 23/04/2018, principal investigator: Jin-Tae Kim). The study was conducted in accordance with the Declaration of Helsinki, and written informed consent was obtained from all the patients.