Objectives {7}
death, skeletal muscle, overdose
DRUG WITHDRAWAL, EVENTS, SECONDARY
The primary objective of this trial is to test the effectiveness of a health-system-embedded deprescribing intervention on the incidence of medically treated falls with a sample of older adults who are long-term users of one or more CNS-active medications. CNS-active medication classes targeted by the intervention include the following: opioids, sedative-hypnotics (benzodiazepines and Z-drugs), skeletal muscle relaxants, tricyclic antidepressants, and first-generation antihistamines. Participants will be followed for up to 26 months. We will also examine (1) discontinuation or dose reductions of target medication (secondary outcomes); (2) serious adverse drug withdrawal events (ADWE), (3) unintentional overdose, and (4) death (safety outcomes); (5) evidence of planned dose reductions (process outcome), and (6) factors affecting intervention implementation.