Study design
current bowel disorder, traumatic injury, swallowing dysfunction
SYNDROME, DELAYED GASTRIC EMPTYING
This was a 1:1 randomized, double blinded phase I safety and tolerability study of auto-FMT using acid-resistant capsules compared to placebo capsules. Following donation of a faecal sample, the intestinal microbiota of participants (N = 24) was disrupted by intake of clindamycin capsules. After a two-day washout, study persons were randomized to treatment with autologous faecal matter or placebo. Faecal samples were collected on days 1, 10, 15, 28, 60 and 180 for future microbiome analyses using next generation sequencing, though this data is not yet available. The study protocol is available as Inclusion criteria were as follows; age 18–40 years, ability to swallow study capsules, negative pregnancy test at inclusion, use of an approved method to prevent pregnancy during the study period and written informed consent.Exclusion criteria were previous or current bowel disorder, delayed gastric emptying syndrome, recurrent aspirations, swallowing dysfunction, antibiotic treatment during the previous three months, regular intake of any medication (except vitamin pills and dietary supplements), body mass index <18.5 and >30, any other significant medical history (except resolved traumatic injury) and identification of 