Author contributions
L.T.P., D.K.P, L.Q., and L.Z. conceived the method and initiated the project; L.Q. and L.T.P. supervised the project; L.Q., U.K., X.Z. and Y.N.Z. constructed the clinical system; L.Z., C.J.S., and M.F.C. performed laboratory experiments; D.K.P, M.S.S., P.K.U., T.M.B., J.M.C., X.Z., L.Z. and L.Q. performed clinical measurements, L.Q., E.V., P.K.U. and X.Z. performed the data analysis; D.K.P., T.M.B., I.I, M.S.S., L.Z., L.Q. and L.T.P. evaluated the method; L.C., X.Z. and L.Q. performed statistical analysis; M.F.C, L.Z., U.K., C.J.S., M.G., L.C., I.I. and D.K.P. contributed to the writing of the manuscript; L.Q. and L.T.P. wrote the manuscript.