Trial design and ethical oversight
This study was a pilot, single-dose, single-center, double-blind, and randomized controlled trial conducted in a tertiary hospital in Melbourne, Australia. Ethics approval was obtained from Austin Health Human Research Ethics Committee (HREC/64579/Austin-2020, approval date: September, 17, 2020) and the trial was registered with the Australian New Zealand Clinical Trial Registry (ACTRN12620000651987) before the start of enrolment.Written informed consent for enrolment or consent to continue and use patient data was obtained from all patients or the legally responsible person.