Introduction
migraine, RS, Migraine, neurological disease
MIGRAINE, MIGRAINE, NEUROLOGICAL DISEASE
Migraine is a common and highly disabling neurological disease [The application of advanced magnetic resonance imaging (MRI) techniques has markedly enhanced the understanding of migraine [Here, using a blinded, placebo-controlled design, we primarily aimed to confirm central modifications mediated by erenumab and resting state (RS) functional connectivity (FC) patterns of responders and non-responders after 12 weeks of therapy. Secondary and exploratory aims of the study were to: (1) explore whether central modulation of RS FC contributes to explain the therapeutic effect of erenumab; (2) identify imaging biomarkers of positive response to erenumab; and (3) investigate whether erenumab could lead to sustained central effects after 3-month treatment discontinuation.Gathering data on the effects of erenumab administration, their persistence and their relation with clinical response is crucial for a better understanding of the mechanism of action of this drug within migraine neurobiology.