Secondary outcomes
inflammation, depression, PCOS
INFLAMMATION

Glucose metabolism via HOMA and Matsuda indices as determined through an oral glucose tolerance test.Other hormonal parameters of PCOS (Anti-Müllerian hormone; androstenedione; follicle-stimulating hormone FSH; luteinizing hormone LH; dehydroepiandrosterone-sulphate DHEA-S; 17α-hydroxy-progesterone; 17β-hydroxy-estradiole; total testosterone, 25-hydroxy-cholecalciferol).Hirsutism (modified Ferriman-Gallwey score).Body weight (body-mass-index BMI; waist-to-hip-ratio).Gut permeability and inflammation (functional sucrose-lactulose-mannitol test; surrogate parameters: serum diaminooxydase; stool zonulin; calprotectin; lipopolysaccharide; soluble cluster of differentiation sCD14; bacterial DNA).Gut lumen and mucosa microbiome composition (16 S-RNA gene sequencing).Phytoestrogen production -log10 (equol to daidzein concentration ratio in urine) obtained via the soy challenge test)Quality of life (PCOS questionnaire; depression questionnaires; diet questionnaires).