Sensitivity analyses
acne
ACNE
The results of the sensitivity analyses are presented in There were differential rates of attrition with greater missing data in the no active systemic treatment group, compared with spironolactone group, by 24 weeks follow-up, for costs (39% vs 24%, respectively) and EQ-5D-5L (33% vs 20%, respectively). This may offer some explanation for why, when using MI in a sensitivity analysis, the ICER was less than in the complete case, adjusted analysis (With regards to the oral antibiotic control analysis (SA3), the planned threshold analysis using the complete case, adjusted data found that the incremental QALY benefit for spironolactone compared with oral antibiotics would have to be 0.00057 (0.000384, MI adjusted) or less, over 24 weeks, for spironolactone to be less cost-effective than oral antibiotics at a £30 000 threshold. The plausibility of this value is unclear but research comparing spironolactone with oral antibiotics, currently underway,Of note regarding the wider perspective sensitivity analysis (SA4), the majority of women (97%) reported no impact on their employment as a result of their acne and, thus, it is mainly out-of-pocket expenses driving change from the base-case.The results of a subgroup analysis undertaken for women aged <25 years and ≥25 years are reported in 