Discussion
binge eating behavior, metabolic BAT-brain
The current study reveals in vivo that secretin induces metabolic BAT-brain crosstalk, as indicated by the negatively correlated glucose uptake rates after secretin infusion. Using functional measures of neuroactivity, our study also shows that secretin directly enhances inhibitory control, extending our previous report that secretin downregulates of brain responses to appetizing food images and causes satiation [Secretin modulated the correspondence between caudate GU and cerebral BOLD signals during food-reward responses (Mechanism of the secretin-induced satiation. BOLD, blood-oxygen-level-dependent signalOur previous studies have highlighted that BAT has a dual role in maintaining energy homeostasis [The role of the caudate in reward-oriented action has been well established [Secretin’s suppressive effect on acute brain responses to appetizing food images and enhancement of cognitive control further highlights its potential role in weight control. Previous studies have shown that binge eating behavior is associated with enhanced BOLD response to rewarding food images [How this metabolic crosstalk between BAT and caudate occurs remains elusive. BAT is largely innervated by the central nervous system [We have previously shown that human BAT has high expression of secretin receptors and that secretin infusion enhances thermogenesis [