Discussion
MR, endometriosis
ENDOMETRIOSIS
Nowadays, gender in clinical is an increasing topical issue, with the report of large sample cohort studies, the incidence of AS in women is gradually approaching in menThe MR analysis has a statistical advantage. Clinical studies are sometimes affected by confounding factors, for example smoking and menstruation.So, epidemiological studies may not be able to directly infer a causal relationship between AS and endometriosis. However, MR analysis can use SNPs as genetic variants to assess the causal relationship between exposure IVs and outcome IVs. Since genetic variation affects outcomes only through changes in exposure, they are randomly assigned and fixed before birthThe underlying mechanism triggering endometriosis and AS remains unclarified. Some studies have shown that endometriosis and AS may share the same genetic basis of variation, Matalliotaki et al.There are limitations to this study. It should also have more AS-related IVs, and a larger sample size study would be more helpful for AS causality between endometriosis and provide more valid conclusions.