Statistical analyses
All patients who had received at least 1 dose of talazoparib were included in the safety and efficacy analysis sets. All treated patients with at least 1 PK concentration in the single-dose and/or multiple-dose PK part were included in the PK concentration analysis set, and all treated patients with at least 1 of the PK parameters of primary interest in the single-dose and/or multiple-dose PK part were included in the PK parameter analysis set. All patients in the PK parameter analysis set who completed both the single-dose PK and multiple-dose PK parts without major protocol deviations were included in the PK evaluable analysis set.Talazoparib PK parameters were calculated for each patient and each treatment, as applicable, using non-compartmental analysis of concentration-time data. Summary statistics were calculated by setting concentration values below the lower limit of quantification to zero.