Statistical analyses
schizophrenia
SECONDARY
The primary endpoint was the average percentage of conditioned responses in the EBC task at day 8. Pairwise comparisons between active treatments and placebo were generated with an analysis of variance (ANOVA) in a within-subject manner, with treatment sequence, period, and treatment as fixed effects. Subject nested within sequence was included as a random effect. The dependent variable was the change in response from the period baseline assessment to the final treatment day for each period, and the response data were logit transformed before the change was calculated. The primary endpoint was tested individually for each of the two doses against 5% (one-sided) level of significance. Sample size was determined based on prior studies using EBC and MMN in patients with schizophrenia. The secondary EEG endpoints were analyzed using an ANOVA model like that used for the primary endpoint and were tested individually for each of the two doses against 5% (one-sided) level of significance.The changes from baseline in concentrations of D-serine, L-serine, and the ratio of D-serine to total serine were compared using a mixed model for repeated measures (MMRM). Sequence, period, treatment, and time point were fixed effects, and subject nested within sequence was a random effect.