Methods for additional analyses (e.g. subgroup analyses) {20b}
hernia/hernia, diabetes mellitus, hernia, non-COPD, abdominal aortic aneurysm, SSI, seroma, hematoma, COPD
CARDIOVASCULAR DISEASE, DIABETES MELLITUS, POSTOPERATIVE COMPLICATION, COPD, RENAL DISEASE, SEROMA, REGRESSION, HEMATOMA, COMPLICATIONS
Pre-specified subgroup analysis will be performed in the FAS population for the rate of IH in the following subgroups: (a) body mass index (< 27 vs. ≥ 27), (b) neoadjuvant therapy (yes/no), (c) COPD vs. non-COPD, (d) previous laparotomy vs. previous minimal invasive surgery and (e) history of hernia/hernia repair vs. no history of hernia/hernia repair.Furthermore, uni- and multivariate analyses using two-level binary logistic regression models will be performed to find risk factors for IH. Factors that will be included in the model (besides the fixed factors treatment group and IH risk, and the random factor centre which are already used in the primary model) are age, BMI, sex, presence/absence of diabetes mellitus with chronic complications, corticosteroid use, preoperative (radio)chemotherapy, renal disease, smoking, previous laparotomies, COPD, cardiovascular disease, history of hernia or hernia repair, history of abdominal aortic aneurysm, ASA classification, occurrence of SSI, postoperative complication (Dindo-Clavien), seroma formation, hematoma formation and length of hospital stay.Furthermore, the treatment effect will be assessed descriptively within several subgroups of interest to identify potential prognostic and predictive factors.