Generalized estimation equations
Generalized estimating equations were used to model categorical change on the individual symptom items of the MPN‐SAF v2.0 to estimate the treatment‐related difference in the odds of “improved” versus “stable or declined/worsened.” Models included fixed effects of treatment, time point, treatment‐by‐time point interaction, and stratification variables, along with an R‐side random patient effect. Results were accompanied by graphic presentations for each statistical test conducted including forest plots of odds ratios for experiencing meaningful change in the treatment group versus placebo with 95% CIs around each odds ratio for each symptom item.