4.4. BMI Percentage Loss Prediction Model Based on the MHP and LF Diets’ Methylation Data
BMI loss, weight loss
The model that predicts the percentage of BMI loss was made with a total methylation score that was constructed considering the MHP diet methylation score, in which the 15 CpG sites that were better associated with the reduction of BMI percentage were selected and 11 CpG sites for the LF diet. With this model, it was possible to predict with which diet the highest percentage of BMI would be lost for 75 participants, corresponding to 37.3% of the total population of this study. We consider that this total methylation score could be used to predict which diet is more appropriate for each individual. If not significant, the predictive model indicates that these subjects would lose a similar percentage of BMI with both diets. In this case, and in order to increase the adherence to the treatment, the individuals could choose by dietary preference.The potential of DNA methylation to predict BMI loss has been described before, as demonstrated in a study in which a prediction score was performed based on 83 CpG sites that was associated with BMI; the result they obtained was a prediction that represented 29% of the variation in BMI in the population they studied [To conclude, it is important to mention that this pioneer prediction model can be improved by adding other information, because the use of other variables for the prediction of the decrease in anthropometric measurements with a dietary intervention has been evidenced. For example, a useful weight loss prediction model using gut microbiota data and urine metabolites in a nutritional intervention has been recently published [