Randomization and blinding
In this parallel double-blind trial, the computer-generated random allocation sequence was created by an independent investigator using SPSS Statistics (version 24.0, IBM Corp., Armonk, NY, USA) with a 1:1 allocation and random block size. After providing written informed consent, the eligible patients were entered into the trial within 2 h of the emergency visit and were randomized into the trial and control groups using sealed opaque envelopes to reveal the treatment arm. None of the patients or data collectors were aware of the grouping.