Evidence before this study
inflammation, PWH, CVD, HIV (PWH
CVD, INFLAMMATION, CARDIOVASCULAR DISEASE
Aspirin can reduce cardiovascular disease (CVD) risk in the general population, in part through its anti-inflammatory properties. For example, aspirin is known to reduce levels of pro-resolving (i.e. anti-inflammatory) lipid mediators of inflammation. Persons with HIV (PWH) have higher risk of CVD and aspirin administration could potentially reduce CVD risk in this population. We searched PubMed through August 20, 2022 for studies on “aspirin” AND “HIV” AND “lipid mediators of inflammation” (or variations of these terms), but could not find any study that comprehensively assessed pro-inflammatory and pro-resolving lipid mediators of inflammation in PWH before and after aspirin intervention. Further, we only found one small study (n < 20 per group) that assessed lipid mediator of inflammation profile in PWH.