Competing interests
D.H.
L.B.K. has received consulting fees from Blueprint Medicine as DSMB Chair and has contracted institutional research with Novartis, Regeneron Pharmaceuticals, Day One Biopharmaceuticals, Spring Works Therapeutics, Bristol Myers Squibb and SonALAsense. L.B.K. also owns stock in Onconova Therapeutics. J.R.H. has received honoraria for consultation from Bayer, Alexion Pharma and Boxer Capital. P.H.D. is on an advisory board with Alexion and is part of the Alexion ICI Sprinkle Study. S.P. is on advisory boards with Bayer, Alexion and Esai and has received research support from Novartis, Bayer and Roche. D.S.Z. has received consulting/advisory board fees from Bayer, AstraZeneca, Accendatech, Novartis, Day One Biopharmaceuticals, FivePhusion, Amgen, Alexion and Norgine and has received research support from Accendatech. O.W. is on advisory boards with Novartis, Janssen, Roche, Bristol Myers Squibb and AstraZeneca and has received research grants from Day One Biopharmaceuticals, Biomed Valley Discovery, Bristol Myers Squibb, Syndax and PreComb. H.J.K. is on advisory boards with Novartis, Jazz Pharmaceuticals, Takeda, Cartexell and GPCR. D.H. is on advisory boards with Alexion/AstraZeneca, Bayer, Bristol Myers Squibb, Celgene, Day One Biopharmaceuticals, Janssen, Novartis and Roche and has received research grants from Alexion/AstraZeneca and Roche. V.L. is on an advisory board with Alexion. C.K. is a study chair of an investigator-sponsored trial for which Day One Biopharmaceuticals provides drug and research support; she also has research relationships with other industry partners. D.S. is on an advisory board with Alexion. L.M., X.Z., A.W., D.D., P.M., I.C. and S.C.B. are employees of Day One Biopharmaceuticals and have received Day One Biopharmaceuticals stock and stock options. K.N. has received advisory board or consulting fees from Y-mAbs, EUSA Pharma, Bayer and Eli Lilly. All remaining authors declare no competing interests.