Cardiovascular Magnetic Resonance
MRS
All cardiovascular magnetic resonance (CMR) assessments took place in the Oxford Centre for Clinical Magnetic Resonance Research (OCMR, University of Oxford). ECG-gated magnetic resonance imaging was performed at baseline (visit 2) and after 12 weeks of treatment using a 3-T scanner (MAGNETOM Prisma; Siemens Healthineers, Erlangen, Germany). Imaging sequences included steady-state free precession cine imaging, ShMOLLI T1–mapping, resting perfusion and late gadolinium enhancement imaging. A detailed description of the entire scanning protocol is provided in our published design manuscript.Binuclear (MTG of the heart was assessed via proton MRS using an 18-channel surface coil supine in end-diastole and expiration. This enabled acquisition of water-suppressed, and non–water-suppressed lipid spectra, allowing the calculation of MTG.