Ethics statement
RECRUITMENT
The studies involving human participants were reviewed and approved by Research Ethics Committee from all recruitment centers approved the study protocol, according to the ethical standards of the Declaration of Helsinki. All participants provided written informed consent. All centers have the ethics approval and consent from all the Ethics Committee, and within them, the Ethics Committee of Research of Balearic Islands (ref. CEIC-IB2251/14PI). The patients/participants provided their written informed consent to participate in this study.