Effect modification analysis
CKD, shock, non-sepsis, AKI, sepsis
MALNOURISHED, SEPSIS, SHOCK
We hypothesized that among patients with AKI, the following subgroups may modify the association of protein dose on TTDA or 60-day mortality: AKI stage 1, 2 or 3, received vs not received KRT post-randomization (regardless of KRT prior to randomization), ever vs never dialyzed prior to or during the current ICU stay, CKD versus no CKD, blood urea nitrogen to creatinine ratio (BUN; > or ≤ 22), age > or ≤ 59, BMI > or ≤ 30, mNUTRIC ≥ or < 5, SOFA ≥ or < 9, APACHE II ≥ or < 21, medical vs surgical patients, sepsis vs non-sepsis patients, patients who were in shock vs not in shock, frailty ≥ or < 5, SARC-F ≥ or < 4, malnourished vs non-malnourished. The within subgroup estimates and tests for subgroup by treatment interaction were obtained by adding a treatment arm by subgroup interaction term to the models previously described to analyze TTDA and 60-day mortality. We tested for interactions between protein target and the 16 subgroups across two outcomes, but since no test for interaction reached statistical significance at 0.05, we did not adjust 