Background
diabetic models, death, pre-diabetic, pre-diabetes
METABOLIC DISEASES, INFLAMMATION, INSULIN RESISTANCE, PRE-DIABETIC, PRE-DIABETES, PATHOLOGY
Edited by: Benoit Pourcet, Université de Lille, FranceReviewed by: Paola Llanos, University of Chile, Chile; Shulin Yang, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, China†Lead ContactThis article was submitted to Inflammation, a section of the journal Frontiers in ImmunologyDiabetes is one of the most common metabolic diseases and continues to be a leading cause of death worldwide. The NLRP3 inflammasome has been shown to exert detrimental effects on diabetic models. However, evidence linking NLRP3 inflammasome and pre-diabetes has been scarcely explored. Herein, we aimed to determine whether the NLRP3 inflammasome correlates with insulin resistance and liver pathology in a cohort of pre-diabetic subjects.