Conclusions
CHRONIC INFLAMMATION, PATHOPHYSIOLOGY
After 8 weeks of low-dose prednisone chronotherapy, there was a statistically significant increase in the physical HRQOL of GWI+ Veterans with baseline PCS <40. This result supports the hypothesis that chronic inflammation is a component of GWI pathophysiology. A Phase 3 RCT is necessary to determine the efficacy of low-dose prednisone chronotherapy as a treatment for GWI.