Statistical analyses
Experimental data were expressed as the mean ± s.e.m. of three or more individual experiments. The two-tailed Wilcoxon rank sum test was used to evaluate differences between unpaired data; the Wilcoxon signed rank test was used to compare paired data.As detailed in the clinical protocol, descriptive statistics were used to summarize efficacy, including response rate (with 95% CI). PFS and median overall survival were calculated via Kaplan–Meier. Descriptive statistics were also used to report rates of AEs. General power calculations for the clinical trial cohort were based on a sample size of at least 