Quantitative data preparation and analyses
EVENTS
Patient and caregiver characteristics will be demonstrated descriptively. Descriptive statistics will also describe health state fluctuations' occurrence, frequency, and intensity. The occurrence will be operationalized dichotomously: no fluctuations reported vs. at least one fluctuation reported. The frequency will be quantified as the number of fluctuations within 14 days. The intensity will be operationalized as follows: much worse or better = ±2; somewhat worse or better = ±1; about the same = ±0) of the reported health events. We will demonstrate the intensity of the health state fluctuations as a mean change per day with standard deviation.Furthermore, we will use exploratory data analysis of the EQ-5D-5L data by reporting the number and percentage of patients reporting each level on each dimension of the EQ-5D-5L using simple descriptive statistics (To assess the association between occurrence, frequency and intensity of the reported health fluctuation and (i) the differences between the baseline, 7-day and 14-days follow-up EQ-5D-5L profile, health utility and EQ-VAS as well as the (ii) reporting of consideration of these health state fluctuations in the assessment of health today in the EQ-5D-5L, we will use appropriate statistics such as cross tables with ANOVA, 