Introduction
alopecia, Alopecia
ALOPECIA, DERMATOLOGICAL DISORDERS, DISORDERS, ALOPECIA
Alopecia is classified into two categories, which are cicatricial and noncicatricial alopecia [Although it is also encountered in females, AGA is more prevalent in males of various ages. AGA manifests after puberty and progressively worsens with age [There are currently few AGA treatments available, yet little have met expectations [The development of biotechnologies to enhance hair regrowth in AGA is clinically necessary. This implies that the aim of hair tissue engineering (HTE) must be the invention of new autologous technologies involving hair regrowth. In order to promote hair development, autologous stem cells have attracted a lot of attention. As a potential treatment for AGA, platelet-rich plasma (PRP) and micrografts containing human follicular mesenchymal stem cells (HF-MSCs) were tested [The application of cell-based therapy as an alternative to treat medical disorders has skyrocketed in recent years. Specifically, stem cell therapy has been used to manage various dermatological disorders [Nevertheless, there have been limited randomized, placebo-controlled trials in the Asian population that aim to observe the efficacy of ADSC-CM therapy in AGA. Therefore, we conducted a randomized clinical trial to evaluate the effectiveness and tolerability of ADSC-CM for treating male AGA in combination with minoxidil. Based on existing evidence, we believe that this combination could serve as a prospective and safe agent to induce hair growth, particularly in male patients with AGA.