Statistical analysis
SECONDARY
The mean BoP at 8 weeks was defined as the primary outcome variable. All other parameters were considered secondary outcomes. All calculations were performed by GraphPad Prism 6 (GraphPad Software, Inc., San Diego, CA, USA). Each clinical parameter was computed per participant and then averaged across patients in both groups. The significance level was set at 5% in all tests.Normality of the distribution and the homoscedasticity of the data were analyzed by Kolgomorov Smirnoff and Bartlett test, respectively. The variables BoP, GI ≤ 1, and PI were normally distributed and the significance of differences between groups was determined using unpaired 