Results
comorbid neurological or psychiatric disease, depressed, depression, Depression, white matter hyperintensities
WHITE MATTER HYPERINTENSITIES
The study enrolled 162 depressed elders (Consort diagram. The majority of people who were not eligible at the screening visit were due to MRI contraindications, not meeting depression severity criterion, or having other comorbid neurological or psychiatric disease. Most placebo arm withdrawals were for worsening symptoms. Most drug arm withdrawals were for medication intolerance.Demographics tableCIRS, Cumulative Illness Rating Scale; MADRS, Montgomery-Asberg Depression Rating Scale; MMSE, Mini-Mental State Exam; WMH, white matter hyperintensities (in milliliters).Continuous variables presented as mean (standard deviation), with categorical variables presented as percent (N). Continuous variables were compared between treatment arms using pooled, two-tailed tests with 88 degrees of freedom. Categorical variables were compared using a χOf the 95 participants who were randomized (