Secondary outcomes
TB
EVENT
To assess correlation of specific MDR-TB drug serum concentrations with observed adherence, bedaquiline and linezolid pre-dose concentrations (CWe will compare time to sputum culture conversion in the intervention and control arm using time to event analysis. We shall also use chi-square testing to compare treatment success rates in the intervention and control arms. Treatment success will be evaluated using a composite outcome that includes TB cure (for microbiologically diagnosed patients) and TB treatment completion (for clinically diagnosed TB). We will undertake per-protocol and intention to treat analyses to compare TB cure rates in the two study arms. We will determine the proportions of patients retained in care of retention in care at 2 and 6 months in the two study arms using chi-square tests. Study outcomes by randomization arm will be compared using a generalized estimating equations (GEE) model using repeated measures with identity link, exchangeable correlation structure and robust variance estimates. Adjusted coefficients along with their corresponding 95% CIs will be generated. Statistical significance will be set at the 