INTRODUCTION
autoimmune blistering disease, Pemphigus vulgaris
MUSCLE ATROPHY, DISEASES, COMPLICATION, ADVERSE EFFECTS, PEMPHIGUS VULGARIS, AUTOIMMUNE BLISTERING DISEASE
Pemphigus vulgaris (PV) is a potentially fatal autoimmune blistering disease that affects the skin and mucous membranes. It is characterized by autoantibodies against the antigens of the intercellular junctions of keratinocytes, desmoglein (Dsg) 1 and 3 (Dănescu et al., CONSORT Flow Diagram.
Glucocorticoids are immunosuppressants widely prescribed for a multitude of diseases. With over 50 years of usage, they are among the most recognized mycotoxins agents. The long period of treatment and high dose of these drugs have many adverse effects on patient's physiology such as muscle atrophy, a complication which leads to intolerance to treatment, poor prognosis, low quality of life, and high mortality are some of the side effects in patients (Ringseis et al., 