Statistical analysis
SECONDARY, INTERACTIONS
Numeric variables that followed a gaussian distribution are presented as mean (standard deviation), while those with a non-gaussian distribution (i.e., median ≠ mean) are shown as median (interquartile range, 3rd quantile–1st quantile). Category variables and count data are specified as numbers or fractions, with values rounded to two decimals. Values smaller than 0.005 are presented as < 0.005, and values greater than 1 million are expressed in scientific notationPrimary and secondary outcomes, as well as MADRS scores, were analyzed blindly by one of the authors (B.P.P) who did not know the group assignments. Both intention-to-treat (ITT) and per-protocol analyses (PP) were performed using linear mixed models (LMM) for the primary and secondary outcomes. We calculated the interaction Interactions were corrected for Statistical analyses and descriptive data were conducted using IBM SPSS Statistics software, version 26.0 (International Business Machines Corporation, New York, United States of America). LMM analyses were performed using the R-based software jamovi 2.0.0