3.2. Primary Endpoint: Improvement in BIA and TOL Test Scores
With regard to the cognitive indicators measured by mean scores of the BIA and TOL tests, the following variables were identified for BIA:Sustained visual attention (identified from the number of omissions in the continuous performance subtest);Impulsive behavior (calculated from the number of errors in the MF subtest);Inhibitory control (identified with the response time of the MF subtest);Selective auditory attention (represented by the auditory attention test score);Motor inhibition (obtained from the frogs test score).The following variables were identified for TOL:Organisation and planning (representing the number of moves score);Problem-solving (obtained from resolution time);Executive functions (calculated from the main score of the test).A correlation analysis was conducted between the BIA variables at T0 and T1 and between the TOL variables at T0 and T1. The results are reported in We highlighted the following results:A significant positive correlation between the values of the scores for the variables “Sustained Visual Attention”, “Impulsive Behaviour”, “Inhibitory Control”, and “Auditory Selective Attention” of the BIA test at T0 and T1;A significant positive correlation between the values of the scores for the variables “Organisation and planning”, “Problem solving”, and “Executive functions” of the TOL test at T0 and T1.This shows that there is a relationship between the values at the initial and post-treatment time. From this initial observation, we examine the weight of the relationship between the variables at the two different times by analyzing the difference between the mean scores obtained in the tests in order to establish their significance in terms of improvement.A descriptive analysis of the averages of these variables at T0 and T1 was also conducted (Our statistical analysis shows a significant improvement in the areas of attentional processes, problem solving, sustained auditory attention, and task planning and organisation and, more generally, an improvement in executive functions. Last, we proceeded to calculate the RCI value for the individual variables (