Conflicts of interest
Author Russell is an employee of and owns stock in Exact Sciences. Author Foreman is a former employee of Exact Sciences. Author Meisel has conflicts of interest caused by honoraria as follows: AstraZeneca, Clovis, Genentech, Glaxo SmithKline, Novartis, Pfizer, Puma, Sanofi Genzyme, and Seagen. She also has conflicts of interest caused by research grants or other funding from Seagen, Pfizer, and Olema. The remaining authors have no conflicts of interest.