WHAT THIS STUDY ADDS
cerebellar haemorrhage, epistaxis, purpura, petechiae, Bleeding, RA
EPISTAXIS, DISEASE, HAEMORRHAGE SUBCUTANEOUS, PURPURA, PETECHIAE, BLEEDING, EVENTS
This randomised, double-blind, phase IIa study found that TAS5315 numerically improved measures of disease activity in Japanese patients with RA who had an inadequate response to methotrexate.Bleeding events (haemorrhage subcutaneous, petechiae, purpura, cerebellar haemorrhage and epistaxis) occurred in three patients in the TAS5315 combined group in part A and in six patients in part B; four and two patients recovered with continued drug administration and interruption, respectively, and three patients recovered after TAS5315 discontinuation.