Heart rate
irritability
One participant had a gradual increase in heart rate at 1-hour after commencing the infusion at 0.3mg/kg and peaked with an increase over baseline of 51%, reaching 98 beats/min 4-hour post infusion completion. The participant attributed this to the questionnaire burden, although study intervention can increase irritability. The heart rate increase for that participant did not recur at the higher dose of 0.4mg/kg in the subsequent week. For the rest of the group, there was no clinically meaningful increase of median change from baseline heart rates at all time points on the intervention days (max +3.1%; +2.0 beats/min).