Acknowledgements
This study is supported by research grants MOST 106-2314-B-002-106, 107-2314-B-002 −222 -MY3, and 110-2314- B002-121-MY3 from the Ministry of Science and Technology (MOST), Taiwan. The MOST peer-reviewed this study protocol before granting the funding. Then the MOST played no role in operation of this project and did not have any involvement in the preparation, review, approval, or decision to submit this manuscript for publication. We appreciate Dr Hiroyoshi Takeuchi's thoughtful inputs to strengthen the rationale of our approach. We also thank Dr Ko Yen for assistance with ascertainment of medical records.