3.4.1. Psychometric Measures
Psychometric results from 19 subjects in PLC (13 in PLC-D and 6 in PLC-DMS) and 25 subjects in PRO (19 in PRO-D and 6 in PRO-DMS) were analyzed. The mean changes between time-points V2 and V1 with 95% confidence intervals are shown in We performed an analysis of preliminary data gathered through this pilot study. While comparing groups regarding the MADRS score, the size effect was 0.51, and the power was 0.49. With this data, in order to achieve a power of 0.8 the study should involve approximately 240 subjects (60 in each subgroup).