Discussion
bone loss, tooth
PROLIFERATION, ALVEOLAR BONE RESORPTION, BONE LOSS
This randomized controlled trial was designed to evaluate the efficacy of recurrent application of C-PRF injections inside the extraction sockets on the hard and soft tissue dimensional alterations following tooth extraction. This study represents the first clinical study to evaluate the effectiveness of recurrent C-PRF injections for ridge preservation.PRF is prepared from the patient’s blood without adding any materials. Therefore, it’s resorbed completely without leaving any negative effects. In contrast to PRF, socket augmentation with bone graft is more expensive, time consuming, and may leave some residual materials that can affect the osseointegration of the dental implant later on [In this study, statistically significant differences in the horizontal and vertical dimensions were observed between the groups after 3 months of healing. Ridge preservation using A-PRF + with recurrent C-PRF injections demonstrated lower alveolar bone resorption than A-PRF + alone by 1.5 times. For the A-PRF + group in this study, the amount of horizontal and vertical bone loss was 2.9 mm and 1.8 mm, respectively. These results were comparable to Clark’s clinical trial results [Several studies have shown the positive effects of the recurrent application of liquid PRF injections for soft tissue healing and improvement [There are many preparation protocols for liquid PRF. However, it was shown that C-PRF collected from the buffy coat layer following high centrifugation protocols represents a novel harvesting technique that was recently developed to extract higher concentrations of platelets/leukocytes. This protocol produces PRF with the greatest potential for cell migration and proliferation, with a higher level of TGF-β1, PDGF-AA, and EGF in comparison with other traditional preparation protocols [For soft tissue thickness in this study, there were no statistically significant differences between groups in the third month, and this result is comparable to Avila-Ortiz’s study results [This clinical trial, however, had many limitations. Further studies with a larger sample size are recommended. Histological investigations are also recommended to assess bone quality following the recurrent application of C-PRF injections. Another limitation in this study was the use of a fixed-angle centrifuge instead of a horizontal centrifuge. Finally, we recommend using surgical templates and CBCT to ensure the accuracy of clinical outcomes.