Statistical Analysis
depressive, manic
SYNDROMES
We investigated “bridge” symptoms in a network model that were highly associated with depressive (assessed by 17 CDRS-R item scores) and manic (assessed by 11 YMRS item scores) syndromes. In this analysis, “bridge” symptoms were defined based on the following pre-specified criteria [In the network analysis, the graphical Least Absolute Shrinkage and Selection Operator (LASSO) method [We used clinical trial data and the statistical interaction test for “bridge” symptoms by treatment to evaluate the associations of “bridge” symptoms with treatment outcomes in Analysis of Covariance (ANCOVA) and mixed model for repeated measures (MMRM). The residual symptoms of “decreased need for sleep“ (week-6 YMRS item 4 > 0 