Postprandial Dairy Effect in the Serum Volatilome
While
not present in dairy products, 3,5-dimethyloctan-2-one was previously
shown to be specifically increased in serum after intake of milk and
cheese but not a soy-based drink.Relative concentrations of 3,5-dimethyloctan-3-one, a candidate
biomarker of dairy products, during the 3 week restricted period (V1,
V2, V3) and during the 6 h postprandial test after milk (M0, M15,
M30, M60, M90, M120, M180, M240, M300, M360) and yogurt (Y0, Y15,
Y30, Y60, Y90, Y120, Y180, Y240, Y300, Y360) challenge. YA: young
adults, OA: older adults.Interestingly, no age or product effect was observed
for the postprandial
behavior of this molecule. However, the restriction phase resulted
in a decrease in the fasting levels of 3,5-dimethyloctan-2-one, that
was only significant in the OA group, although the In this study, we also
evaluated the dairy effect among the 21
identified metabolites demonstrating a postprandial change combined
with an age or product effect. Only octanoic acid had a significant
postprandial response after milk and yogurt intake and showed a change
during the 3 week restriction phase in the OA group. In other words,
the postprandial increases in octanoic acid after milk and yogurt
intake were preceded by a significant decrease in their fasting levels
during the 3 week restriction phase (see Interestingly, octanoic
acid not only demonstrated a significant
dairy effect in the OA group, but also an age effect was observed
both after milk and yogurt intake (see 