Limitations and Strengths
VASCULAR DISEASE
The main strength of this study was the randomised double-blind crossover design that reduced bias and number of participants needed. The study included a disproportional number of females compared with males and participants were healthy and relatively young individuals, which makes it hard to extrapolate results to older individuals with established vascular disease. Present results might not be applicable to regular EC users, as the exposure regime of 30 puffs in this study is low compared with the mean vaping amount of 120–235 puffs daily estimated for regular EC users [