Electroencephalographic assessment
Changes in low‐beta EEG power (averaged absolute power at 12–25 Hz) after the administration of zuranolone and placebo were measured by normalization with baseline EEG power in frontal regions (Fz, F3, F4, and average of three electrodes). EEG measurements were obtained immediately before and 3, 5, 6, 8, and 24 h after zuranolone administration on Day 1. Enhancement of low beta‐band power was observed in the EEG assessment for the zuranolone 30‐mg group but not for the 10‐mg group, suggesting that a single 30‐mg dose is sufficient to induce GABA