Safety outcomes
nausea, diarrhea, abdominal pain
DRUG WITHDRAWAL, EVENTS, EVENT
Serious adverse drug withdrawal events (ADWE) due to opioids or benzodiazepines.Urgent care, ED visits, or hospitalizations for an adverse drug withdrawal is the trial’s main safety outcome. For participants mailed an opioid or benzodiazepine brochure, we will identify possible withdrawal events using ICD-10 codes for drug (opioid or benzodiazepine) withdrawal and withdrawal symptoms (e.g., for opioids, nausea, diarrhea, abdominal pain), over 12 months from brochure mailing. Information related to the reason for the healthcare event and course of care will be abstracted from the EMR. Two study team members will independently review the abstracted chart, blinded to the intervention status and use a published algorithm to assess the probability that the symptoms represent an ADWE [