Trial design
AKI, critically ill
CRITICALLY ILL
This study was a single center, pragmatic, unblinded, quasi-randomized cluster trial in which the use of CVVHD was compared with pre-filter CVVH among critically ill adults with severe AKI at the University of Iowa Hospitals and Clinics (UIHC) between March 2020 and December 2020. The study was considered quasi-randomized because time-based clusters alternated between modalities.