Statistical analysis
stroke
STROKE, EVENTS
The predefined statistical analysis plan dictated the use of mixed logistic models to assess the effect of reminders on Subgroup analyses were done by (i) DOAC type (once-daily vs twice daily), (ii) stroke location (right vs left hemisphere), (iii) Fazekas score (0–3) and (iv) MoCA score (0–30). Analyses were done on an intention-to-treat basis as prespecified in the statistical plan and were repeated in the per-protocol population (including only patients who used the reminder according to randomisation). We investigated time-trend and carry-over effects in sensitivity analyses. The effect of the counselling session and pillbox was assessed by comparing overall adherence during the observational phase and the first half of the interventional phase without the reminder (group 2). We present clinical events of interest and patient satisfaction with the reminder descriptively. All analyses were performed in R (version 4.1.2). Study outcomes were reported according to the CONSORT guideline [