CONFLICT OF INTEREST
Naoto Takahashi has received honoraria from Pfizer, Otsuka, and Novartis; research funding from Pfizer, Otsuka, Novartis, Chugai, Eizai, Asahikasei, Ono, and Kyowahakko‐Kirin outside the submitted work. Yosuke Minami received research funding from Ono and CMIC, and honoraria from Bristol‐Myers Squibb, Novartis, Astellas, and Daiichi‐Sankyo. Itaru Matsumura received honoraria from Novartis Pharma KK, Bristol‐Myers Squibb, Pfizer Japan Inc., Daiichi Sankyo Co Ltd., Otsuka Pharmaceutical Co Ltd., Astellas Pharma Inc., Amgen Astellas BioPharma K.K., Janssen Pharmaceutical K.K., AbbVie GK.; research funding from Chugai Pharmaceutical Co., Ltd., Novartis Pharma KK, AbbVie GK., Takeda Pharmaceutical Company Limited., Pfizer Japan Inc., Eisai Co., Ltd., Alexion, Asahikasei, Ono, Kyowahakko‐Kirin, Shionogi & Co., Ltd., Sumitomo Dainippon Pharma Co., Ltd., Nippon Shinyaku Co., Ltd., Taiho Pharmaceutical Co., Ltd., Mitsubishi Tanabe Pharma Corporation, Sanofi K.K., Astellas Pharma Inc., Otsuka Pharmaceutical Co., Ltd, MSD K.K., outside the submitted work. Hiroshi Matsuoka received research funding from Takeda Pharmaceutical Company Limited, Sysmex Corporation. Takafumi Yokota is an employee of Teijin Limited and received research funding from LUCA Science Inc. Akihiro Tomita received research funding from Perseus Proteomics Inc, Novartis Pharma K.K., Pfizer Japan Inc, Chugai Pharmaceutical Co., Ltd., Kyowa Kirin Ltd., Ono Pharmaceutical Co., Ltd., and Taiho Pharmaceutical Co., Ltd. Akio Maki, Makoto Aoki, and Alex Allepuz are employees of Novartis. Noriko Doki, Kohmei Kubo, Keita Kirito, Tatsunori Goto, and Junichiro Yuda have nothing to disclose.