Explanation for the choice of comparators {6b}
stroke
STROKE, CORTEX
The comparison between the Experimental Condition and Control Condition 1 will reveal to what extent brain‐oscillation‐synchronized rTMS is more effective than non‐brain oscillation‐synchronized but otherwise identical rTMS, i.e., it will address the comparison of primary interest in this trial. The comparison between the Experimental Condition and Control Condition 2 will address the important question to what extent it is the real brain stimulation rather than somatosensory and auditory inputs synchronized to the ongoing brain oscillation that causes the therapeutic effect. Use of a combined active/passive stimulation coil with realistic auditory and somatosensory stimulation enables stimulation that blinds both the patient and the treatment provider to the condition.The dose (number of stimuli per session, number of sessions) was adopted from previous stroke trials that used high‐frequency rTMS of the ipsilesional motor cortex in early subacute stroke patients [