Safety
skin erosion, adverse reaction, stoma prolapse, stoma, sepsis
SKIN EROSION, SEPSIS, BOWEL PERFORATION, ADVERSE REACTION
The MFR intervention was discontinued for 3 infants in the normal-output MFR group temporarily due to bowel distension/ prolapse/ skin erosion around the stoma and resumed after symptom improvement. The MFR intervention was terminated for one infant in the MFR group after a severe adverse reaction was reported. This patient received MFR for 10 days and suffered from bowel perforation during the manual reduction for stoma prolapse, thus requiring termination of MFR. Though the intervention was not interrupted because of an unclear association with MFR, two episodes of culture-proven sepsis (associated with Cases of culture-proven sepsis after enterostomy