Limitations
cognitive impairment
DISORDERS
Our findings must be considered in the context of several potential limitations. First, although we rule out disorders and other factors that could affect cognitive impairment, it remains possible that other as yet unidentified behavioral or neurobiological factors contribute to the cognitive biotype. Second, although our sample was representative of multiple racial and ethnic backgrounds and clinical settings, the findings must be evaluated for generalizability. Third, the pragmatic biomarker design of the trial focused on 3 commonly prescribed antidepressants and the relevance of our approach to other antidepressants and treatment modalities requires investigation. Finally, within the mediation models, we acknowledge some overlap in measures used to allocate 