Antiviral activity
BLOOD
The changes in the serum levels of HBV DNA, HBV pgRNA, HBcrAg, HBsAg, HBsAb, HBeAg, HBeAb, and HBcAb at different time points were examined. Blood samples were collected on the initial screening day (baseline) and days 1, 8, 15, 22, 29, 43 ± 1, and 57 ± 2 postdosing. Blood samples for detecting viral resistance to Canocapavir were collected on day 1 (predosing), day 29 (24 h after day 28 dosing), and day 57 ± 2 postdosing.