Introduction
colorectal neoplasia, first-degree, colorectal cancer, CRC
COLORECTAL CANCER
Family history and older age are the most important risk factors in colorectal cancer (CRC) development. The risk of developing CRC is almost doubled among first-degree relative (FDR) of patients diagnosed with CRC over the age of 60 years old. However, it is increased up to 3 to 4 times if the index case is younger than 60 years, and if there are siblings or 2 or more FDR affected in the family, regardless of age at diagnosis [Apart from heightened risk, a pooled analysis of 8 epidemiological studies has shown that most individuals with a family history of CRC do not have a worse prognosis than those with no family history [Decision analytic modeling suggests that colonoscopy screening is cost-effective in this population, assuming a 100% participation rate [A meta-analysis of 12 studies assessed the performance of fecal immunochemical testing (FIT) to detect colorectal neoplasia in those with familial risk [