RANDOMIZATION
RECRUITMENT
Following recruitment and consent, a random list of all the subjects was created online (https://www.random.org/) by an individual who was not involved in the trial. The allocation sequence was concealed from research personnel and assessor, using sealed opaque envelopes, which were numbered sequentially and were chosen by the patients. Subjects were randomly allocated in 1:1 ratio into the two arms of this study i.e.: Group PE - Premolar extraction treatment (mean age = 13.03±1.78 years) and Group FF - Fixed Functional Appliance Therapy (mean age = 12.80±1.67 years), with 23 subjects each. There was no restricted randomization.