Study Design
Age-Well was a monocentric, observer-masked, randomized clinical trial with 3 parallel arms: an 18-month meditation training intervention arm, an 18-month non-native language (English) training intervention arm, and an arm with no intervention. Participants completed a prescreening visit, with eligible participants invited to a baseline preintervention visit, before being randomized. A midintervention visit was performed after 9 months, and a postintervention visit performed at the end of the intervention. The preintervention and postintervention visits comprised multimodal assessments, including cognitive, behavioral, neuroimaging, and biological assessments, while the 9-month visit included select behavioral measures only. Age-Well received ethical approval from the Comité de Protection des Personnes Nord-Ouest III in Caen, and this study followed the Consolidated Standards of Reporting Trials (