What This Article Tells Us That Is New
ventilator-induced lung injury, ARDS
COVID-19 ACUTE RESPIRATORY DISTRESS SYNDROME, ARDS, RECRUITMENT, ACUTE RESPIRATORY DISTRESS SYNDROME
In a cohort of patients with moderate to severe COVID-19 acute respiratory distress syndrome, the authors determined respiratory mechanics and end-expiratory lung volume by nitrogen dilution over a 10–cm HThe global effect displayed a linear correlation of both global and granular recruitment-to-inflation ratio with dynamic strain reduction. However, granular recruitment-to-inflation ratio showed high intraindividual variability, suggesting nonuniform recruitability across a 10–cm HA nonlinear quadratic relationship was noted between granular recruitment-to-inflation ratio and PEEP.These pilot data suggest that the recruitment-to-inflation ratio measured across a 10–cm HMechanical ventilation represents the mainstay of supportive therapy in the acute respiratory distress syndrome (ARDS), aiming at maintaining gas exchange while limiting the occurrence of ventilator-induced lung injury.A high interindividual heterogeneity in the potential for lung recruitment with PEEP has been described.Measurement of end-expiratory lung volume through the nitrogen dilution technique looks promising in this contextThe recruitment-to-inflation ratio is assessed through a simplified maneuver and estimates the potential for lung recruitment within a 10–cm HWe report the results of a physiologic study conducted in moderate-to-severe COVID-19 ARDS to determine the behavior of recruitment-to-inflation ratio across the conventionally tested 15– to 5–cm H