Incretin profile changes with surgery
When analyzing the incretin profile after MTT, a restoration of the typical slope for GLP-1 and GLP-2 was observed with the corresponding increase in AUC for both hormones after surgery: GLP-1 AUC pre 9731 vs post 15788 pM, P<0.05 and GLP-2 AUC pre 732 vs post 1190 ng/ml, P<0.001 (GLP-1 and GLP-2 response to MTT at baseline and 1 year post-surgery. These figures show mean and standard deviation of GLP-1 (expressed in pM) and GLP-2 (expressed in ng/ml) at each time point after meal tolerance test (MTT). Baseline represented in blue and follow-up in red.Within the study sample comprising 13 participants, of which 9 were female, representing over 50% of the cohort, an investigation into potential differences in GLP-1 and GLP-2 levels before and after surgical intervention was conducted among the female subgroup, consisting of 4 pre-menopausal and 5 post-menopausal individuals. The analysis revealed that there were no statistically significant distinctions in GLP-1 and GLP-2 levels between the pre-menopausal and post-menopausal groups before and after the surgical procedure.