Author contributions
M.R., D.V., F.R., C.S. conceived and designed the study. M.R., A.F.-M., D.V. contributed to develop the methodology. J.C., K.V.B., D.W.H. provided statistical support. B.S., E.P.W., S.E.-A., M.P., S.DC., W.F.S., I.E.K, R.S., S.L., L.P., C.M.P., L.A.C. contributed to data acquisition and to the design of the study. M.R., A.F.-M., D.V., F.R., C.M.P., L.A.C., C.S. analyzed and interpreted the data. M.R., A.F.-M., D.V., K.A.H., J.S.P. performed the analyses. D.V., K.A.H., J.S.P. provided bioinformatics support. C.M.P., L.A.C., F.R., C.S. supervised the analyses and the study. M.R., A.F.-M., D.V., L.A.C., C.S. prepared the manuscript, which was reviewed and approved by all authors.