Mild-exercise intervention
Participants assigned to the ME group participated in three exercise sessions per week for 12 weeks, supervised by qualified exercise specialists. For safety, participants self-monitored their resting heart rate and blood pressure and reported them, along with any daily subjective symptoms they may have been experiencing, to trainers before every session. Participants started by cycling for 30 min, and the duration was increased monthly by 10-min increments until a duration of 50 min was achieved at month 3. All cycling sessions started and ended with 5 min for warming up and cooling down. Trainers adjusted the individual workload of the recumbent ergometer (Monark RT2, Vansbro, Sweden) to correspond to 35% of the 