Author contributions
AS contributed to conception of work and study design. ZK, ER and AS contributed to the acquisition and interpretation of data. DT, LS, HB, SK, VL and StH contributed to the interpretation of data. ZK, ER, JS and AS drafted the report. AS and JS are the guarantors of this work and, as such, had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. All authors contributed to the article and approved the submitted version. 