Ethics approval and consent to participate
In accordance with local regulations, the protocol gained Ethical and Research approval from the council of the OB/GYN Department, Ain-Shams University. Furthermore, the study protocol was approved by the Ethics Research Committee, Faculty of Medicine, Ain-Shams University (number: FMASU M S 410 / 2020). Written informed consent was obtained from every candidate after explaining the procedure before enrollment. WE Confirm that All methods were performed in accordance with the relevant guidelines and regulations according to the Declaration of Helsinki.