Sequence generation {16a}
We propose to match the 8 centers in their characteristics of number of patients and punctures per day.The different experimental and control groups move forward in pairs.There are 4 pairs, each comprising two centers. They are constituted in such a way that the 2 centers in each pair have similar characteristics, such as a comparable level of activity, a similar number of caregivers, particularly nurses, and a similar geographical environment in terms of urban and rural characteristics.There were 4 centralized randomizations carried out by the Clinical Research Department of the Caen University Hospital. The TT group and the TTST group for each pair are already constituted. Consent, contrary to the Zelen method, is requested before randomization (Fig. Randomization