Introduction
tumor
TUMOR
Treatment of BRAF V600-mutated melanomas with a RAF inhibitor, such as dabrafenib, results in rapid adaptations including loss of MAPK pathway feedback inhibition (Phenformin can also affect the tumor immune microenvironment. Recently, we demonstrated that phenformin selectively inhibits myeloid-derived suppressor cells (MDSC) in mice by inducing reactive oxygen species (Phenformin, typically at doses of 50–100 mg/day (