Sample size
INFECTIOUS DISEASE
Assuming intubation rates of 10% in the teprenone group and 22% in the controls, the required sample size to afford a statistical power of 64% with a one-sided 0.1 type 1 error was 50 patients per arm. The intubation rate of 22% in controls was based on the weekly report (in Japanese) dated March 17, 2020, from the National Institute of Infectious Disease [