Discussion
myocardial ischemia/reperfusion
ATRIAL FIBRILLATION (AF), CORONARY HEART DISEASE, PCT
Among patients with CPB, 0.5 mg of colchicine once daily resulted in lower levels of cTnT, cTnI, and CK-MB on the second postoperative days than the placebo. During the period of postoperative 5 days, the colchicine could also significantly decrease levels of cTnT, IL-6, and PCT. And the level of cTnI might be decreased in the colchicine group during the postoperative 5 days compared with the placebo group. The postoperative troponin levels have been shown to be associated with prognosis [There is great interest in using anti-inflammatory therapies in order to reduce the risk of myocardial ischemia/reperfusion injury. Colchicine deemed as an economical treatment that targets inflammatory mechanisms and seems safe and useful for patients with coronary heart disease [The incidence of atrial fibrillation (AF) after cardiac surgery is usually 23.7% [To the best knowledge, our study is the first single-center RCT in the world to assess the effect of colchicine on perioperative cardioprotection in patients who need valvular or aortic surgery but CABG. Giannopoulos et al. [