Introduction
allergic inflammatory diseases, PMBL, Allergic rhinitis, grass pollen-induced AR
ALLERGIC RHINITIS
Allergic rhinitis (AR) is one of the most common allergic inflammatory diseases worldwide and it has a significant economic impact through its effects on education, productivity and use of healthcare resources (There are many drugs for AR, including: intranasal corticosteroids, oral and intranasal H1-antihistamines, leukotriene receptor antagonists, intranasal anticholinergic, intranasal and oral decongestants, intranasal saline, allergen immunotherapy and anti-IgE therapy (γδT cells are a small subset of human T cells, comprising approximately 1–10% of T cells. They have a T cell receptor (TCR) built of γ and δ chains instead of α and β. These cells combine characteristics of both innate and acquired immune response and are frequently recognized as the ‘bridge’ between them (Another lymphocyte population capable of a sudden release of large amounts of cytokines is invariant natural killer T (iNKT) cells, a rare subpopulation (up to 0.5% of T cells) that combines features of typical T and NK cells (The purpose of this study was to evaluate the effect of PMBL therapy on the clinical course of grass pollen-induced AR in children, and primarily to characterize the immunomodulatory effects of this treatment.