Long-term follow-up
respiratory failure, pneumonia, pneumothorax, leukopenia
DISEASE PROGRESSION, BRAIN METASTASIS, PNEUMONIA, PNEUMOTHORAX, LEUKOPENIA, RESPIRATORY FAILURE, SECONDARY, COMPLICATIONS
There were no signs or symptoms of complications in any of the patients during the follow-up. One patient developed post chemotherapy leukopenia in relation to the adjuvant treatment applied which improved after drug protocol modification. We did not detect a pneumothorax on X-ray or pathological findings on CT in any of the patients during follow-up at months 1, 3, 6, 12 or 24 follow-ups.One patient died before finishing the initial follow-up (2 years) due to disease progression (brain metastasis), which was diagnosed 19 months after the surgery. The patient who did not receive the MSCs because of insufficient cell expansion died 14 months after surgery due to respiratory failure secondary to pneumonia. The remaining four patients were followed for more than six years, and no pathological outcomes were reported in the routine clinical and radiological exams.Regarding patients treated with MSCs as compassionate use, they were alive and no treatment-related complications or pathological findings were detected after a follow-up longer than 50 months.The main long-term follow-up outcomes are summarized in Table Follow-up