Incidence of clinical malaria one month post dose 2 in cohort 2
malaria, fever
MALARIA
The trial was not designed to measure vaccine efficacy but an additional exploratory objective was to look at differences in malaria incidence. There were very few malaria episodes in Cohorts 1 (n = 4) and 3 (n = 1). Cohort 2, in which subjects received three vaccine doses prior to the rainy season, experienced more episodes of clinical malaria (defined as ≥ 5000 parasites/µL + fever, ≥ 38.0°C) with 5 episodes among 30 participants in the BK-SE36/CpG arm (5/30) compared with 8 episodes in 15 participants in the control arm (8/15) (rate ratio compared to control arm = 0.31, 95% CI 0.1-1.0, 