Introduction
OUD
Opioid and cocaine use are associated with morbidity and mortality, and co-use of opioids and stimulants is increasing in the United States.This double-blind, placebo-controlled randomized clinical trial examined whether bupropion SR and monetary-based incentives reduced cocaine use in persons maintained on methadone for OUD while accounting for the moderating role of early abstinence. Because persons who show early response to treatments (eg, abstinence) are highly likely to remain abstinent throughout treatment,