ACE genotype and exercise capacity
cardiovascular conditionsIn
Exercise capacity is a powerful predictor of the risk of all-cause mortality in patients with cardiovascular conditionsIn our study, we assessed the impact of the ACE I/D genotype on baseline exercise capacity and training-induced adaptations in exercise capacity, since previous research has reported that the I/I genotype is associated with greater baseline exercise capacityFinally, we also performed a sub-analysis to assess the effect of the ACE genotype on baseline exercise capacity as well as exercise capacity trainability for the patients not treated with ACE inhibitors. Excluding ACE inhibitor users from the analysis did not significantly modify any of the obtained measures of exercise capacity, and hence no significant between-group effect was observed for pre-training exercise capacity or the magnitude of exercise capacity improvements. Our findings should, however, be interpreted with care because the low sample size in conjunction with the large variations in exercise capacity measurements augments the risk of undetected effects.