RESULTS
manic, disruptive-aggressive behavior, mania, bipolar depression, irritability
Baseline characteristics were similar for the lurasidone and placebo treatment groups (Table The two most prevalent manic symptoms at study baseline in this sample of youth with bipolar depression were “decreased need for sleep” at 53.1% (182/343) (YMRS item 4 > 0) and “irritability” (YMRS item 5 > 0) at 84.0% (288/343). These two symptoms were followed in prevalence by: “disruptive-aggressive behavior” (YMRS item 9 > 0) at 38.8% (133/343), “reduced insight” (YMRS item 11 > 0) at 24.8% (85/343), and “appearance of mania” (YMRS item 10 > 0) at 22.7% (78/343). The remaining YMRS symptom items were observed in less than 15% of the study participants.