Author contributions
Y.H., H.L., X.Z., Y.D. and J.N. were involved in the conception, design, and analyses of the data; Y.H., H.L., H.Z., X.C., J.C., Z.X., H.Y., R.D., Y.P., J.L., X.L., D.W., L.Z., D.C., H.J., D.Q., A.Y., J.Lou, X.Z., Y.D. and J.N. performed the clinical trials, acquisition and interpretation of the data; Y.H., Y.D., and J.N. participated in the drafting of the paper; Y.H., H.L., H.Z., X.C., J.C., Z.X., H.Y., R.D., Y.P., J.L., X.L., D.W., L.Z., D.C., H.J., D.Q., A.Y., J.Lou, X.Z., Y.D. and J.N. contributed to revising the paper critically for intellectual content and approving the final version to be published; Y.H., H.L., H.Z., X.C., J.C., Z.X., H.Y., R.D., Y.P., J.L., X.L., D.W., L.Z., D.C., H.J., D.Q., A.Y., J.Lou, X.Z., Y.D. and J.N. agree to be accountable for all aspects of the work.