Intra-articular injection of IMRCs is safe
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ADVERSE EVENTS, BLOOD, BLOOD CLOTTING
All participants tolerated the injection procedure well, with no serious adverse events (SAE) associated with IMRCs during the post-procedure period. Four of the 18 patients (22.2%) experienced symptoms of mild adverse events (AEs), including joint pain after injection in 1 case of the mid-dose group and local swelling sensation in the knee joint in 3 cases of the high-dose group (Supplementary Table Blood tests, including complete blood count, basic metabolic panel, blood enzyme tests, blood clotting tests, human lymphocyte subsets and inflammatory cytokines, were almost in the normal reference range and showed no significant change after injection (Supplementary Table Clinical trial shows the safety profile of IMRCs by blood tests at six time points post-injection. 