Immune cell profile analyses in responders and non-responders
Subsequently, we assessed the abundance of 14 predefined immune cells based on the nCounter immune profile panel. At the metagene level, the score of total T cells was significantly decreased in non-responders compared to responders (6.9 vs. 7.7, In a previous report, accumulation of progenitor-exhausted T cells was found as an important mechanism in response to anti-PD1/PD-L1 therapy