5. Conclusion
postoperative pain, nephrotoxicity, bleeding, pain
EVENTS, BLEEDING, GASTROINTESTINAL DYSFUNCTION
In conclusion, the results of this study suggest that IVIB 400 mg and 800 mg ibuprofen administrating postoperative pain before 30 minutes the end of surgery, with Injection every 6 hours, 8 times in total, can reduce morphine consumption, which may reduce recognized opioid-related AEs associated with postoperative analgesia, also achieved effective pain relief. Regarding the incidence of AEs associated with IVIB, gastrointestinal dysfunction, bleeding, nephrotoxicity, and cardiovascular or neurological events, there were no significant differences between the 400 mg group, the 800 mg group, and the placebo group; IVIB was well tolerated for postoperative pain treatment.