Statistical analysis
Data were coded and entered using the statistical package for the Social Sciences SPSS (IBM, Armonk, NY) version 24. Data was summarized using mean, standard deviation, median, minimum, and maximum in quantitative data and using frequency (count) and relative frequency (percentage) for categorical data. Comparisons between quantitative variables were done using the non-parametric Mann–Whitney test. For comparison of serial measurements within each patient, the non-parametric Wilcoxon signed rank test was used. For comparing categorical data, Chi square (