INTRODUCTION
cancers, fatigue, diarrhea, nausea and vomiting, pain, lung cancer, constipation, debilitating symptoms, malignant tumor, disorder of the gut microbiome
CANCERS, ADVERSE EVENTS, LUNG CANCER, APPETITE LOSS, MALIGNANT TUMOR
Despite significant improvements in the realm of anticancer strategies, whatever chemotherapy is administered as a monotherapy or in combination with other treatment paradigms encompassing surgery, radiotherapy, immune checkpoint inhibitors (ICIs), antiangiogenesis agents, targeted therapies, and beyond, it remains an important treatment strategy for almost all cancers, especially lung cancer, the most prevalent and fatal malignant tumor in the population.Platinum‐based doublet chemotherapy occupies an important role in the management of lung cancer; however, there are treatment‐associated side effects which include nausea and vomiting, fatigue, appetite loss, pain, constipation, diarrhea, and many other debilitating symptoms that may deteriorate the quality of life for patients undergoing chemotherapy, and even necessitate dose reduction or discontinuation.Chemotherapy can also damage the gastrointestinal epithelial cells and result in a disorder of the gut microbiome.Many strategies for controlling chemotherapy‐related adverse events have been applied in clinical practice during the past decades, but the management situation is not optimistic in the real world.