2.1. Study Design and Ethical Considerations
WEST
A 12-week randomized, single-blind, parallel-group clinical trial was conducted at West China Hospital of Stomatology, Sichuan University, Chengdu, China. The research program was approved by the Research Ethics Committee of West China Hospital of Stomatology, Sichuan University (WCHSIRB-D-2021-493). This study was conducted in full compliance with the Declaration of Helsinki, the related regulations of the People’s Republic of China, and Good Clinical Practice. This trial was retrospectively registered in the Chinese Clinical Trial Registry (ChiCTR, Registration number: (ChiCTR2100054254)).