PATIENTS AND METHODS
In this study, single‐blind participants are blinded to the parallel group that was initiated within a single institution. The study was approved by the Saga University Hospital Research Ethics Committee (Protocol number 2019‐07‐01), and informed consent was obtained from all subjects and/or legally acceptable representative (LAR) of subjects to participate in the study.　This trial was registered at the University Hospital Medical Information Network (UMIN) Clinical Trials Registry (Registration number UMIN000046091). This study followed the 2010 Consolidated Standards for Reporting Trials (CONSORT) statement.　The study was performed in line with the principles of the declaration of Helsinki. Regarding setting sample size, there were few similar research reports in the past. This study was conducted under the actual conditions of daily clinical practice, and the sample size was set as the number of possible cases within the study period.