Materials and methods
MAY
This study was conducted as a single-center, prospective, randomized, partly blinded, controlled trial in a tertiary, university affiliated hospital between May 15, 2019 and January 30, 2021 in accordance with the principles of the 2013 Declaration of Helsinki. All experimental protocols were approved by a named institutional was approved by the Institutional Review Board of Beijing Tong Ren Hospital (TR-IRB no:20170828) and was registered at ClinicalTrials.gov (