Conclusions
hormone-dependent diseases
SHR7280 was well-tolerated for 14 consecutive days of use within a dose range of 100 to 1000 mg BID in healthy men. SHR7280 showed a rapid onset of action and was dose proportional. Its suppression of hormones was quick and reversible. These findings provide a rationale for further clinical development of SHR7280 as a potential androgen deprivation therapy for hormone-dependent diseases in men.