2.1. Clinical Trial Treatment Protocol
IDH
After newly diagnosed GBM patients completed surgery, sMRI scans were acquired along with standard imaging to guide radiation treatment. At each participating site, a Siemens 3T scanner was used to perform an echo planar sMRI pulse sequence with GRAPPA parallelization with either a 32- or 20-channel head coil. The scan was acquired with an echo time of 50 ms, repetition time of 1551 ms, and flip angle of 71 degrees, leading to a scan time of 15 min and a nominal voxel size of 108 μL [In For the cohort of 30 patients who received treatment, 2 had an IDH mutation, 9 were MGMT hypermethylated, 11 had a gross total resection (defined by whether their pre-RT T1w-CE lesion volumes were less than 1 mL), and 19 had a subtotal surgical resection [