Changes in fMRI activation during the emotional face processing task and cognitive reappraisal task.
PTSD
Columns depict brain regions in which the change in activation during the task from pre-treatment (T1) to post-treatment (T2) significantly correlated with changes in PTSD symptoms. Scatter plots on the second row depict change in signal intensity in the identified region and percentage reduction in PTSD symptoms. Bar plots in the third row depict mean activation in these regions at T1 and T2 for the PTSD and control groups.ROIs displaying significant correlations with CAPS change scores were selected as seed regions for the connectivity (gPPI) analysis. The insula regions were split into anterior and posterior subregions (see supplementary section) because each pole correlated in opposite directions with CAPS change scores in the activation analyses. Using the left hippocampus as seed, significant negative correlations with CAPS change scores were found for the left amygdala (