Patients
juvenile psoriatic arthritis, JIA, uveitis, polyarticular JIA
DISEASE, UVEITIS, JUVENILE PSORIATIC ARTHRITIS
The BeSt for Kids study (NTR 1574) is a Dutch multicenter randomized single-blinded trial. It was designed to investigate the effectiveness of three different treat to target strategies for non-systemic JIA patients. Newly diagnosed patients between 2 and 16 years old with JIA (oligoarticular JIA, RF negative polyarticular JIA and juvenile psoriatic arthritis) were included. Exclusion criteria were a disease duration of more than 18 months, uveitis at enrolment and prior DMARD therapy.Patients were randomized between three strategy arms. Patients in arm 1 were initially treated with methotrexate(MTX) or sulfasalazine(SSZ) monotherapy. Patients in arm 2 initially received MTX and 6 weeks prednisolone bridging. Patients in arm 3 were initially treated with etanercept (ETN) and MTX. Patients were treated to target, with inactive disease (as defined by Wallace [The BeSt for Kids study was approved by the Institutional Review Board at Leiden University Medical Center and written informed consent was obtained from all participants before enrolment.