Introduction
Rashes, allergic skin, Cutaneous adverse drug eruptions, immunologic intolerance, skin injury, hypersensitivity
INFLAMMATORY RESPONSES, DRUG REACTION, SECONDARY, INFILTRATING, HYPERSENSITIVITY
Rashes, drug reactions, and allergic skin responses are encountered in everyday medical practice. The skin is a complex organ, maintained by tight homeostatic control of native and infiltrating cells. Local skin injury can trigger a reactionary cascade leading to a multisystem response. Cutaneous adverse drug eruptions, especially to topical chemotherapeutics, present a frequent iatrogenic challenge to both patients and clinician: 30%–80% of patients develop reactions severe enough to warrant treatment discontinuation (Cholecalciferol (vitamin DIn the present study, we aimed to investigate whether a single intervention of high-dose oral VitDDuring our analysis, we also discovered a striking divergence in the degree of participants’ inflammatory responses to low-dose topical NM. While it is well established that topical chemotherapeutics may induce treatment-limiting reactions secondary to hypersensitivity and immunologic intolerance in some patients undergoing longitudinal therapy, these reactions are often attributed to the concentration, total dose, or formulation of the medication and typically develop over time with repeated applications (