Discussion
paresthesia, infections or gastrointestinal bleeds, postoperative nausea and vomiting, hyperglycemia, postoperative fatigue, PONV, MP, THA, trauma
HYPERGLYCEMIA, INFLAMMATION, PARESTHESIA, INTESTINAL OBSTRUCTION
In our research, we delved into the possibility of MP and TXA amalgamation to additionally lessen postoperative inflammatory reactions and stimulate swift recuperation. As far as we are aware, there is a lack of extensive research examining the effectiveness and safety of MP and TXA combined usage in patients undergoing total hip replacement procedures. The principal discoveries of our research indicate that the MP and TXA combination resulted in a significant decrease in postoperative CRP and IL-6 measurements, enhanced analgesic response, reduced the frequency of PONV and postoperative fatigue, expedited patients' rapid recovery, and did not heighten the risk of perioperative infections or gastrointestinal bleeds.Earlier investigations [Several factors contribute to postoperative nausea and vomiting (PONV), including surgical procedures, individual predisposition, the use of anesthesia and analgesic drugs, and importantly, the stimulation of inflammation. Recent studies suggest that the congregation of immune cells and inflammatory mediators, triggered by surgical trauma, may incite postoperative intestinal paresthesia or even lead to full-blown intestinal obstruction [However, the appropriate dose of MP in patients undergoing total hip arthroplasty (THA) remains contentious [Glucocorticoids administered preoperatively may induce hyperglycemia during the perioperative period [While the beneficial clinical efficacy of MP has been supported by numerous prior studies [