Adherence assessment
TB, MDR-TB
The primary outcome is the overall adherence rates among MDR-TB patients on self-administered therapy and on DOT. For the participants on the intervention arm, opening of the devices will be equated to a patient swallowing their medication and adherence will be derived from the number of days the device was opened as a proportion of the total number of days in the entire period of their MDR-TB treatment. Patients on the intervention arm will be required to take no less than 70% of their medication to be considered as having good adherence. For participants on the control arm (DOT), adherence information will be obtained from their TB treatment cards. Adherence rates will be calculated from the number of days that they report to the DOTS facility as a proportion of the total number of treatment complaint days in the entire period of their MDR-TB treatment. Participants who take their medication at least 80% of the time (missing no more than 5 days each month) will be considered as having good adherence.The primary analysis will be a comparison of overall adherence in each arm. Adherence by self-administration (proportion of expected openings of the MEMS devices) and DOT (proportion of DOT visits) will also be compared at 2 months and 6 months in the intervention and control arms. The chi-square test and 1-way analysis of variance models will be used to compare outcomes by randomization arm. We shall use independent samples 