Ethical approval
The trial was approved by the BREC of the University of KwaZulu-Natal (BFC 104/11) and the Medicines Control Council of South Africa. Our consent procedures included: at home level, for each survey round, verbal consent of the homestead’s owner and of the head of household, as well as individual written consent. For participants aged 16 or 17, we collected both the assent of the participant and the consent of a parent or a guardian.