Safety assessment
The liver function (the total bilirubin (TBIL), direct bilirubin (DBIL), indirect bilirubin (IBIL), albumin (ALB), alanine aminotransferase (ALT), aspartate aminotransferase (AST)) and renal function (serum creatinine (Scr) and blood urea nitrogen (BUN))of all participants was assessed on day 0 and day 84.