4. Discussion
obesity, T2D, muscle contraction, myosin, diabetic, muscle fatigue
OBESITY, INFLAMMATION, INSULIN RESISTANCE
Vibration stimulation of skeletal muscles and tendons activates muscle spindles, which is termed “tonic vibration reaction”. It activates more motor neurons, which in turn activates motor units and the movement of actin and myosin, increasing muscle contraction [When muscle tissue is stimulated, it secretes myokines, which affect inflammation, glucose processing, and adipose tissue. FGF21 and myostatin, myokine factors, are known to be associated with obesity and insulin resistance [Moreover, because vibration stimulation of skeletal muscle has different physiological effects depending on the parameter settings (e.g., frequency, amplitude, posture), the protocol should be carefully set by a certified professional [More importantly, we need to focus on the specific postures that were performed on the vibrating platform. High-intensity postures such as resistance exercise are difficult protocols for the elderly or diabetic patients in the high-frequency and high-amplitude settings. Because people with obesity and T2D have lower exercise adherence than healthy adults, strenuous resistance exercise accompanied by muscle fatigue is more likely to reduce exercise continuity [This pilot study has several limitations. First, it did not include diabetic patients exclusively. Because it is at an early stage to verify the feasibility of a novel 