Host circadian rhythms compared with metabolite profiles
McSF
Host chronotype as assessed by MCTQ compared with AZA or 6-MP metabolite profiles is shown in Figure Corrected midpoint of sleep (McSF) by Munich Chronotype. Questionnaire compared with time of optimal thiopurine metabolite profile. McSF was calculated my Munich Chronotype Questionnaire at the initial visit. Optimal metabolite profiles were estimates as increased 6-thioguanine (T-TG) and lower 6-methyl-mercaptopurine (6-MMP). If no change in metabolite profile participants were excluded from analysis. The time of McSF between the 2 groups was compared by circular analysis (Hotelling 2-sample test). Azathioprine/6-mercaptopurine (AZA/6-MP).Host chronotype as assessed by MEQ did not predict optimal metabolite profiles. Among the participants who had better metabolite level profiles in the morning vs evening, the mean MEQ score was (1.5 vs 1, 