Ethics approval and consent to participate
This study obtained full ethical approvals: Integrated Research and Approval System (IRAS) -250981, and National Health Service Research Ethics Committee (NHS REC) - 18/YH/0470 before commencement. We ensured that each participant received written informed consent, understood its contents, and then accepted to take part in the study before having them sign it. We confirm that all methods were performed in accordance with the guidelines of the Declaration of Helsinki.