Strengths
ulcers
PRESSURE ULCER, ULCERS
The PENFUP study was a multicenter randomized controlled clinical trial. This study is unique in having administered the interventions in multiple areas of the body per patient at risk symmetrically and in the sacral area simultaneously. Likewise, it implemented the validation of ulcers using photographic records to validate ulcers and their different degrees of complexity. This study was blinded to data analysts, researchers, and pressure ulcer validators. Additionally, the cost-effectiveness study provided a key element that can help hospital health decision-makers decide whether to use any of the two interventions evaluated. Stopping the study, with a low prognosis to detect differences if the sample had been completed due to futility, provides uncertainty in the care of these patients, but can guide future research towards exploring the impact on PU prevention using other dressings with characteristics more similar to skin (i.e., silicone, hydrogel), including cost analysys.