Background
death
DELHI, SEVERE ACUTE RESPIRATORY SYNDROME, MULTI-ORGAN FAILURE
Most individuals infected with severe acute respiratory syndrome coronavirus-1 (SARS-CoV-2) experience mild symptoms, however the progression to severe COVID-19 is characterised by multi-organ failure, and a high risk of death [Early variants of SARS-CoV-2 required the Angiotensin Converting Enzyme 2 (ACE2) receptor, and transmembrane serine protease 2 (TMPRSS2) on the cell membrane to facilitate cell entry [In this context, we report a phase 2 randomised placebo-controlled trial (RCT) comparing the addition of low dose spironolactone and dexamethasone (SpiroDex) to standard of care with dexamethasone (Dex) in a hospital setting in Delhi, India.