Protocol adherence
neurologic decline
Compliance and protocol adherence were high (99%, 1854 of 1872 doses possible), and blinding was intact. Reasons for non-administration of the 18 doses were as follows: hemodynamic parameters not met (11 cases), nursing error (4), pharmacy error (1), and problems with enteral access for clonidine (1). Study drug was discontinued in one patient due to rapid neurologic decline with plans for no further escalation of care. Study drug was never held due to physician preference, physician error, lack of IV access, or the patient not being present in the ICU (e.g., receiving MRI). Patients received non-study 