Conclusions and Relevance
neuronal injury, ischemia, cardiac arrest
HYPOXIC-ISCHEMIC BRAIN INJURY, ISCHEMIA, PATHOLOGY, CARDIAC ARREST
In this case-control study, blood biomarkers indicative of AD pathology demonstrated different dynamics of change after cardiac arrest. The increase of p-tau at 24 hours after cardiac arrest suggests a rapid secretion from the interstitial fluid following hypoxic-ischemic brain injury rather than ongoing neuronal injury like NfL or t-tau. In contrast, delayed increases of Aβ peptides after cardiac arrest indicate activation of amyloidogenic processing in response to ischemia.