Discussion
peripheral vascular contraction, hypertension
EVENTS, HYPERTENSION
In this randomized controlled trial of patients undergoing spine surgery, both high and low doses of Dex had little effect on SEP monitoring in intravenous inhalation combined anesthesia. In contrast, low-dose Dex had no effect on the rate of tcMEPs positive events, whereas high-dose Dex increased the rate of tcMEPs positive events significantly.The difference between our study and previous reports is that we added a small dose of inhaled anesthetics based on propofol intravenous anesthesia, whereas previous reports studied the effect of Dex on evoked potentials under TIVA [In our study, the signal of SEPs could be acquired efficiently regardless of the Dex dose. Dex exerts sedative and hypnotic effects by activating the α2 receptor of locus ceruleus and stimulating endogenous sleep-inducing pathways [Similar to our findings, Lee discovered that Dex, as an adjuvant anesthetic, was more likely to result in false-positive outcomes of motor-evoked potentials during intraoperative electrophysiological monitoring of 78 adult patients in a randomized controlled trial [The changes in hemodynamics caused by Dex are notable. In the study, there was a significant difference in the incidence of hypertension between group DH and group C. Dex-related hypertension is typically transient, manifesting primarily during the loading dose, and is associated with peripheral vascular contraction [