1. Introduction
knee arthroplasty, end-stage knee osteoarthritis, blood loss, TKA
BLOOD LOSS, COLD
Total knee arthroplasty (TKA) is recognized as an excellent surgical procedure for patients with end-stage knee osteoarthritis.Intravenous tranexamic acid (TXA) has been shown that can significantly reduce blood loss in total hip and knee arthroplasty.There are several other strategies to reduce BLV during perioperative period, such as cryotherapy, draining clamping and different knee position.However, there are few reports of cryotherapy combined with TXA in TKA, especially continuous cryotherapy. Considering literature reports on the related effects of TXA and cold therapy, it is necessary to explore the synergistic effect of combined application. In this study, our aim is to evaluate the efficacy and safety of continuous cryotherapy combined with TXA in the perioperative period of TKA and explore a new strategy of enhanced recovery after TKA.