Purpose
hypoxaemic respiratory failure, pulmonary edema, pulmonary vascular hyperpermeability, ARDS
ARDS, ACUTE RESPIRATORY DISTRESS SYNDROME, PULMONARY EDEMA, HYPOXAEMIC RESPIRATORY FAILURE
A hallmark of acute respiratory distress syndrome (ARDS) is hypoxaemic respiratory failure due to pulmonary vascular hyperpermeability. The tyrosine kinase inhibitor imatinib reversed pulmonary capillary leak in preclinical studies and improved clinical outcomes in hospitalized COVID-19 patients. We investigated the effect of intravenous (IV) imatinib on pulmonary edema in COVID-19 ARDS.