Statistical Analysis
According to prelimnary data from 11 included patients (written communication with K. Borchert, Bioxpedia A/S, March 7, 2022), 40 patients were required to estimate the antibiotic concentration in the implant pocket after 72 hours with a margin of error of 2 μg/mL and an SD of 6.5 μg/mL. Descriptive statistics were used to present baseline characteristics. Binary outcomes were described as simple proportions, and continuous outcomes were described as mean (SD) values or median (IQR) values, depending on the distribution. For each antibiotic, the concentration over time was modeled as a 3-parameter Weibull dose-response function with a fixed lower limit of zero and with a robust covariance matrix estimation to account for multiple measurements per patient.