Introduction
Heart rhythm disorders
HEART RHYTHM DISORDERS, ATRIAL FIBRILLATION (AF), VENTRICULAR ARRHYTHMIA
Heart rhythm disorders are major causes of mortality and morbidity globally. Atrial fibrillation (AF) is the most common heart rhythm disturbance and the prevalence is exponentially growingThree randomized trials of omega-3 FA supplementation have reported protective effects on SCD and ventricular arrhythmias, whereas the remainder have not. With respect to AF, we recently reported that omega-3 FA and/or vitamin D3 supplementation resulted in no significant difference in the risk of incident AF over a median follow up of over 5.3 years in the VITAL trialThe mechanisms underlying this potential increased risk of AF and lower SCD risk associated with omega-3 fatty acid supplementation are unclear, although cellular electrophysiologic and autonomic mechanisms have been postulatedThe large-scale randomized placebo-controlled VITamin D and OmegA-3 TriaL (VITAL) primary prevention trial