Hyperoxia and myocardial injury
infarct, reperfusion injury, hypoxia, myocardial injury
ACUTE MI, INFLAMMATORY RESPONSES, HYPOXIA, OXIDATIVE STRESS, INFARCT
The role of oxidative stress in reperfusion injury is relatively well established. Abrupt oxidative reactions following reperfusion produce reactive oxygen species (ROS) from cardiomyocytes and endothelial cells, which amplifies local inflammatory responses and leads to a vicious cycle of ROS production [However, in the AVOID trial, patients presenting with acute MI were randomized to receive oxygen 8 L/min via face mask or ambient air, and oxygen treatment increased myocardial injury and infarct size in patients without hypoxia [