Secondary outcomes
REMISSION
For change in mean MADRS scores, ≥50% reduction in MADRS scores (i.e. response) and remission (defined as MADRS score ≤12), there was no significant difference between groups in cohort 1 at the end of the RCT. However, in cohort 2 the reduction in mean MADRS score by treatment end differed between groups by 5.5 points (95% CI 2.1–8.7), and response rates (29% 