TLR7 gene expression response to vaccination.
herpes simplex
VIRUS, HERPES SIMPLEX
Longitudinally monitored TLR expression is plotted for all 60 subjects, colored by sex and separated by herpes simplex virus (HSV) serostatus for vaccine recipients, or with all serogroups combined for placebo recipients.To further assess whether the day 1 responses associated with sex depended on prior exposure to HSV, responses were next compared between men and women, and between each of the three HSV serogroups. Changes in gene expression associated with sex in each serogroup were used to determine differences between the HSV naive group and each HSV exposed group for every gene. This enabled two parallel enrichment analyses; all BTMs that were enriched and showed greater sex-associated differences in the HSV naive compared to exposed groups are shown (FDR adjusted p < 0.05) (