Introduction
adverse drug reactions
SECONDARY, ADVERSE DRUG REACTIONS
In older adults with frailty,Most of the recent pragmatic (ie, conducted under everyday conditions) interventions to facilitate the process of prioritizing and discontinuing medications for older patients with polypharmacy have relied on electronic decision supportFamily conferences are a well-established instrument in nursing and medical care (eg, in intensive care units or palliative care).The aim of this study was to investigate the effects of GP-led family conferences for shared decision-making on deprescribing in community-dwelling older adults with frailty who were receiving polypharmacy. The main hypothesis was that patient safety, reflected as a decrease in hospital admissions, would improve. This intended effect of the COFRAIL intervention, which comprises education and family conferences, should be achieved, on the one hand, directly by reducing adverse drug reactions and, on the other hand, indirectly through better medication adherence and more attentive and individually tailored treatment. The secondary hypothesis related to the decrease in the number and inappropriateness of medications in terms of EU(7)-PIMs.