Blinding and randomization
Patients, outcome assessors, and statisticians will be blinded. Patients in the colchicine treatment group will be given colchicine tablets, and those in the control group will be given starch tablets. We will remove the name of medicine packaging so that patients will not know which group they are in. A research assistant who will not be involved in the study intervention and evaluation will be in charge of the randomization. The random numbers will be generated using Microsoft Excel software in a block size of 4. Patients will be enrolled in a ratio of 1:1. Each patient will get a number according to the date when they sign the informed consent form.