Funding
This study was supported by the National Key Research and Development Program of China (2022YFC2503300, 2022YFE0107600), Projects of International Cooperation and Exchanges NSFC (82220108015), Shandong Provincial Key Research and Development Plan Major Scientific and Technological Innovation Project (2021CXGC011103) and Qingdao Medical and Health Research Program (2021-WJZD168).