Post hoc analyses
infection
INFECTION
Using only provider-collected end-point cervical swabs and excluding self-collected vaginal swabs, the results for the primary analysis were not different: the VE was 98.7% (95% CI 90.5–99.8%) for the nonavalent vaccine and 97.3% (95% CI 89.0–99.3%) for the bivalent in the HPV 16/18 mITT cohort. Nonavalent VE was 95.3% (95% CI 88.4–98.1%) in the HPV 16/18/31/33/45/52/58 mITT cohort (Table Incidence of persistent HPV and vaccine efficacy using cervical swabs only (mITT primary cohorts)Post hoc analysis used cervical swabs only to ascertain end points; all self-collected swabs after month 3 were excluded. Methods are otherwise the same as described in Table The absolute reduction in the HPV 16/18 mITT cohort for cumulative incident-persistent HPV 16/18 infection was −16.0% (95% CI −19.5 to −12.5%) for the nonavalent group and −15.8% (95% CI −19.3 to −12.3%) for the bivalent group; an absolute incidence of 0.2% (95% CI 0–0.6%) in the nonavalent vaccine group and 0.4% (95% CI 0–1.0 %) in the bivalent group compared to 16.2% (95% CI 12.7–19.7%) in the control group. For the HPV 16/18/31/33/45/52/58 mITT cohort, the absolute reduction in persistent HPV 16/18/31/33/45/52/58 infection was −30.1% (95% CI −36.1 to −24.2%) for the nonavalent vaccine; an absolute incidence of 1.6% (95% CI 0.2–2.9%) in the nonavalent vaccine group compared to 31.7% (95% CI 25.9–37.4%) in the control group.