Introduction
HIE, long-term neurologic dysfunction
NEONATAL ENCEPHALOPATHY, HYPOXIC-ISCHEMIC ENCEPHALOPATHY (HIE)
Hypoxic-ischemic encephalopathy (HIE), an important cause of neonatal encephalopathy, results from reduced oxygen and blood flow to a baby’s brain near the time of birth and is an important cause of long-term neurologic dysfunction.Despite numerous studies of neuroimaging biomarkers of HIE, many questions remain. Although some studies found that a normal neonatal brain MRI is highly predictive of a normal outcome after HIE,It is important to determine the best neuroimaging biomarkers of neurodevelopmental outcomes in infants with HIE, both to improve our ability to counsel families and to improve the design of future neuroprotection trials. Prior neuroimaging studies of HIE have been limited by the wide time window during which neuroimaging was performed,