Conclusions
tumor
TUMOR, COMPLICATIONS
The present trial is a multicenter prospective randomized controlled trial comparing SCRT followed by mFOLFOX6 and CRT as two preoperative treatments for LARC. Based on the similar effect on local control between SCRT and CRT as well as the potential systemic effect of neoadjuvant systemic chemotherapy, we hypothesized that preoperative treatment with SCRT and mFOLFOX6 would lead to longer DFS. Quality control measures are implemented to reduce surgery-related complications and achieve competent sphincter preservation, while ensuring adequate local tumor control.