4. Discussion
obesity
OBESITY, DISEASE
PL inhibition has been established as a safe and effective strategy to treat obesity. To date, a tremendous number of chemically diverse PL inhibitors of varying degrees of activity have been identified from a wide range of natural sources such as plant extracts and microbial products. Despite maintained interest in the modulation of intestinal lipid handling by targeting PL, very few of the PL inhibitors have found their way into clinical research [Humans spend most of diurnal time in a postprandial state, and it is increasingly acknowledged that disease development is essentially associated with the dysregulation of substrate fluxes in the immediate postprandial period [