3.6. Gut Microbiome Modulation
MiRKAT
As the gut microbiota is a key player in prenylflavonoid metabolism and bone homeostasis, potential differences in the microbiome composition between the HE and placebo groups were explored. Low-dimensional representations of the taxonomic profiles computed using non-metric multidimensional scaling (MDS) on Bray–Curtis and Jaccard β-diversity scores suggested that there were no differences between the groups at any visit. These exploratory results were also confirmed with MiRKAT overall association tests based on β-diversity (Results shown in Finally, no difference between groups was observed regarding Changes at week 24 and 48 in the profile of total and individual SCFA were not significantly different between groups (