Interpretation
allergic, postoperative infections, postoperative infection
PENICILLIN ALLERGY, POSTOPERATIVE INFECTION
The present clinical trial demonstrated that a single 600-mg preoperative dose of oral clindamycin did not differ from placebo in preventing oral implant failures or postoperative infections following oral implant surgery under ordinary conditions in healthy adults.Several reviews and meta-analyses have demonstrated that a single 2-g preoperative dose of oral amoxicillin may be effective against oral implant surgery; nonetheless, the effectiveness of this treatment was questionable (NNT varied from 25 to 77), and the use of prophylactic antibiotics in oral implant surgery remains controversial [Recent publications have described a wide variation in antibiotic regimens and types prescribed in different countries [Clindamycin is frequently prescribed for penicillin-allergic patients as an alternative to oral surgery; however, researchers have recently reported on the lack of high-quality clinical evidence for its use in oral implant surgery [The present clinical trial represented a further step towards understanding the lack of evidence supporting clindamycin’s prophylactic use.Moreover, the trial can likely investigate the controversy regarding the association between oral implant failures, penicillin allergy, and the use of clindamycin (Salgado-Peralvo et al., 2021a; Salgado-Peralvo et al., 2021b). Considering the exclusion of all participants allergic to penicillin from the trial, we could delimitate the correlation between the possible higher occurrence of implant failures and clindamycin use. Hypothetically, the role of unknown genetic factors in penicillin-allergic participants was excluded from this equation.The low incidence of postoperative infections may be the supposed outcome of standard antiseptic-sterile surgical measures, in combination with the performance of an expert surgeon and limited surgical duration. Nevertheless, the postoperative infection rates (3.2% for the clindamycin group and 6.4% for the control group) were considerably higher but similar to those reported in other clinical trials performed with alternate antibiotics (2.2% for the amoxicillin group and 3.1% for the control group) (Rodríguez Sánchez et al., 2018).