Statistical analysis
We used Simon’s two-stage design. Previous studies of neoadjuvant anthracycline-taxane-based chemotherapy showed a pCR rate of 30%−40% in TNBCFor the endpoints of pCR and objective response rate, the point estimate and 95% confidential intervals (CIs) were summarized descriptively using the Clopper-Pearson method. Post-hoc subgroup analyses of pCR regarding patient characteristics were summarized descriptively and reported with 95% CIs (Clopper-Pearson method). Statistical analyses were performed with SAS version 9.4 software (SAS Institute Inc.) and PASS version 15.0.3 software (NSCC, LLC, Kaysville, UT, USA).