Limitations
This study has some limitations. First, as a post hoc analysis from the OPT-PEACE trial, it should be considered exploratory and was not specifically powered, especially when comparing individual groups. Second, there was an unavoidable selection bias because our study was based on an Asian population and most enrolled patients were men. Our results require validation in further studies with a broader range of patients. Third, each group contained a comparable proportion of patients who consumed alcohol or had 