Statistical analysis
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The statistical analysis was performed with Graphpad Prism software V.8. The results are expressed as means ± SD. Paired t-test was used for intra-group comparisons before and after the intervention. Comparison among the three groups was performed by one-way ANOVA. The interactions between group and time were evaluated by two-way ANOVA. Correlation analysis was performed with Pearson’s test in the whole post-intervention samples. Statistical significance was set at 