Results
periodontitis, cardiomyopathy
PERIODONTITIS, DISEASE, CARDIOMYOPATHY
Out of the 235 patients screened, 180 were enrolled. Two patients were withdrawn from treatment because of cardiomyopathy (1) and pregnancy (1) during the follow-up. Overall, one-hundred-two participants were female (58.8 ± 10.8 years), and 78 (56.9%) were men (54.9 ± 16.5 years). The intervention period lasted for 6 months (8.12 median, ± 13.7 weeks). Baseline characteristics of both trial cohorts were similar. The clinical and biochemical characteristics between groups at baseline are summarized in Table 
Comparisons of the baseline characteristics between participants assigned to groupsThe main effect for degree of periodontitis’ severity was significant, F(15, 19) = 2.32, p = .043, η2p = 0.65, suggesting the linear combination of each dependent variable was significantly different between the levels of severity of disease after controlling for age, smoking status, and sex. The main effect for treatment was significant, F(15, 19) = 4.73, p < .001, η2p = 0.79, suggesting the linear combination of all dependent variables was significantly different between the levels of treatment after controlling for covariates. The covariates, age and smoking status, were not significantly related to dependent variables at each time point, F(15, 19) = 1.61, p = .163, η2p = 0.56, and F(15, 19) = 0.77, p = .695, η2p = 0.38 respectively. The covariate, sex, was not significantly related to each dependent variable, F(15, 19) = 0.93, p = .551, η2p = 0.42. Table 
MANCOVA Results for each dependent variable by severity of periodontitis and treatment while controlling for the covariates age, smoking status, and sexThe ANCOVA results were insignificant, F(5, 34) = 0.77, p = .575, indicating the differences among the degree of degree of periodontitis’ severity and treatment were insignificant (Table 
Analysis of Variance Table for each dependent variable at T0, T1, and T2Table 