Regional decline in tNAA/tCr and Glx/Cr after 12 weeks in the control group
A significant time effect in the dlPFC region for a decrease in tNAA/tCr and Glx/tCr was observed [tNAA/tCr: F(1,31) = 8.474, Group means (SD) along with mean difference (PRE to POST) of specific neurometabolite ratios in brain regions where ANOVA indicated significant time effectsAbbreviations: Additional exploratory analysis with sub-classification of participants in responders and non-responders did not reveal any significant time or interaction effect in any of the three regions (