Study Outcomes
SECONDARY, HYPERTENSION, RECRUITMENT
The data that support the findings of this study are available from the corresponding author upon reasonable request. All outcomes were pre-specified in the trial protocol. The primary process outcome was recruitment rate (number of women eligible, recruited and completing study per month). The primary clinical outcome was reduction in diastolic BP from baseline to 8 weeks post commencement of L-citrulline supplementation.The secondary process outcome was acceptability of the intervention in pregnant women with chronic hypertension. Secondary clinical outcomes were as follows: (i) change in maternal haemodynamic measurements (PWV, augmentation index, central BP and total peripheral vascular resistance) following L-citrulline supplementation; (ii) change in uteroplacental blood flow indices; (iii) change in maternal plasma AAR and angiogenic markers.