Ethics approval and consent to participate
The study protocol was reviewed and approved by the Ethics Committee of the Second Affiliated Hospital of Xinxiang Medical University (XYEFYLL-Scientific research section-2021-06) on 24/02/2021 and was conducted in accordance with the Declaration of Helsinki and subsequent revisions. That is, all experiments were conducted in accordance with relevant guidelines and regulations. All participants were fully informed of the purpose of the study and signed the informed consent form. Patients were informed that their participation was voluntary, and that they had the right to withdraw from the study at any time with no negative effect on their treatment. The study protocol was also registered at the China Clinical Trial Registry on 26/02/2021 (