MATERIALS AND METHODS
manic, bipolar disorder
MAY
This study, as a randomized, double‐blind, parallel‐group clinical trial, evaluated the effect of adjunctive treatment with spironolactone compared to placebo combined with one of the main types of the treatment of bipolar disorder type 1 in manic episodes (sodium valproate) for 8 weeks. It was conducted between May 2021 and November 2021.