Statistical analysis
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Continuous variables were expressed as either mean (± standard deviation or 95% confidence interval) or median (interquartile range, IQR: 25th–75th percentiles) and categorical variables as percentages. Differences between groups were assessed in case of continuous variables by Student Statistical analyses were performed using the SPSS program (SPSS version 20, Chicago, IL), and GraphPad Prism version 9.3.1 (1992–2021 GraphPad Software, LLC).