Introduction
autoimmune disorders, multiple sclerosis, ’ allogeneic, diabetes
AUTOIMMUNE DISORDER, AUTOIMMUNE DISORDERS, TYPE 1 DIABETES, TYPE 1 DIABETES, MULTIPLE SCLEROSIS, DISEASES, COMPLICATIONS, DIABETES
Type 1 diabetes is an autoimmune disorder, affecting 8.4 million people worldwide in 2021 [Despite great advances in insulin formulations and medical technology devices, people living with type 1 diabetes still have an increased risk of complications and, dependent on age at diagnosis and sex, have a shortened life span by 10–18 years [Mesenchymal stromal cells (MSCs) represent a novel approach to diabetes treatment. These multipotent progenitor cells possess innate immunomodulatory, proangiogenic and antifibrotic properties [MSCs have been exploited for their immunomodulatory capacity in numerous diseases including autoimmune disorders such as multiple sclerosis [In this study we generated a drug product from culture-expanded and pooled WJMSCs, ProTrans, under the classification of an advanced therapy medicinal product (ATMP). The aim of this study was to evaluate the safety and efficacy of i.v. infusion of this ‘off-the-shelf’ allogeneic WJMSC product in individuals recently diagnosed with type 1 diabetes.