Limitations
OSA
Even if the present study offers unique data on the effects of a novel drug treatment for OSA over the longest administration period tested so far, we acknowledge a few limitations. First, our findings on the short-term impact of Reb-Oxy on cardiac autonomic modulation in OSA patients cannot be generalize to other populations and need to be confirmed over a longer period. Second, the relatively small sample size was powered to detect significant changes in AHI, not in baroreflex or HRV indices, possibly precluding the detection of smaller effects of the treatment. Third, by study design we evaluated cardiovascular autonomic modulations only by indirect measures, as direct measures of sympathetic activity such as norepinephrine spillover or muscle sympathetic nerve traffic were excluded.