Introduction
tumor, tumors, aggressive embryonal tumor
TUMOR, MEDULLOBLASTOMA, PROLIFERATION, CENTRAL NERVOUS SYSTEM TUMORS, MEDULLOBLASTOMA, TUMOR GROWTH, TUMORS
Medulloblastoma, an aggressive embryonal tumor arising in the cerebellum or, less frequently, in the dorsal brain stem, is one of the most common malignant central nervous system tumors in children.The advantage of metronomic antiangiogenic therapies targeting the tumor microenvironment is that even drugs to which tumors have previously been exposed at high concentrations and have developed resistance can be used. For example, etoposide and cyclophosphamide given at low, long-term dosing to target normal cells that support tumor proliferation, such as endothelium, can produce substantial inhibition of tumor growth, even in tumors made highly resistant to these drugs.A retrospective observational study was recently published of an alternative strategy to treat recurrent medulloblastoma, using a modified 5-drug oral metronomic antiangiogenic therapy.