Introduction
Upper respiratory tract infections, CKD, chronic kidney disease, IgA) predominantly deposits, IgAN, ESRD, hematuria, tonsillitis, upper respiratory tract infections, primary glomerulopathy
UPPER RESPIRATORY TRACT INFECTIONS, HEMATURIA, END-STAGE KIDNEY DISEASE, TONSILLITIS, IMMUNOGLOBULIN A NEPHROPATHY, ESRD, PATHOGENESIS
Immunoglobulin A nephropathy (IgAN) was first described by Jean Berger in 1968 as a kind of primary glomerulopathy, in which immunoglobulin A (IgA) predominantly deposits in glomerular mesangium. Subsequent researches have manifested that IgAN is the most common primary glomerulopathy worldwide, and it is one of the causes of chronic kidney disease (CKD) and end-stage kidney disease (ESRD) [It has been observed that IgAN is mediated by mucosal immunization since the 1970s. Upper respiratory tract infections could aggravate clinical manifestations of IgAN in the early stage. The episodes of macroscopic hematuria associated with upper respiratory tract infections are common in these patients. It has been reported that various pathogens in the upper respiratory tract activate the immunological system by giving rise to tonsillitis, which is involved in the pathogenesis of IgAN [The present study was designed to provide an estimation of the efficacy and safety assessment of fluticasone propionate aerosol in IgAN and help in determining whether a larger multicenter trial with clinical outcomes is warranted.