Introduction
PROLIFERATION
With the change of gestational age, gut microbiota is participated in the physiological adaptation of maternal metabolism (Different from probiotics, galactooligosaccharides (GOS) is a kind of prebiotics that aren’t digested and absorbed by the host, but can selectively promote the metabolism and proliferation of beneficial bacteria in the body, particularly by Lactobacillus and Bifidobacterium (Therefore, prebiotics have the potential to promote health and regulate gut microbiota. However, the beneficial effects of prebiotics during pregnancy remain unclear, the study of GOS prebiotics intervention on pregnant women is still in the preliminary exploration stage. This pilot randomized controlled pilot study aims to evaluate the feasibility, acceptability, and safety of prebiotic intervention for healthy pregnant women, and preliminarily explore the possible benefits for pregnant women.