Conclusion
The investigation documents that the PRECIS-2 and PRECIS-2-PS can be simultaneously used to feasibly and reliably rate pragmatic clinical trial protocols. The quality of pragmatic and implementation clinical trial protocol design, grant review, and manuscripts submissions can be enhanced by the use of common metrics such as the PRECIS-2 and PRECIS-2-PS rating tools. Finally, to optimally address the research-to-practice gap, future integrative study could productively focus on the development of continuum indicators continuum indicators/checklists that assess the extent to which clinical trials successfully catalyze health care system practice changes that are linked to pre-specified policy targets.