Statistics
The expected 3-year DFS with CAC was 72 per cent based on a literature reviewAll randomized patients were defined as the intention-to-treat (ITT) population. Patients with protocol violations, which meant the date of initiating chemotherapy did not meet the protocol, were excluded from the per-protocol population. Safety analyses were performed on the safety population, which meant all patients who received at least one cycle of chemotherapy after randomization. QoL analyses were performed on patients in the safety population who answered QoL questionnaires at baseline and follow-up.The χStatistical analyses were performed using SPSS