2.2. Randomization and Sample Size
EVENTS
The potential participants were selected from a weekly list of patients scheduled for chemotherapy sessions in the upcoming week. Invitation e-mails were sent to the patients, and those who provided informed consent were included in the screening process.From 22 August 2018 to 13 March 2020, 265 patients underwent screening for eligibility in the study. Among them, 35 were ineligible as they did not meet the inclusion criteria (incomplete chemotherapy sessions, undergoing immunotherapy, non-oncologic diagnosis, or inadequate clinical conditions). Additionally, 54 patients declined to participate, and one patient was isolated due to contact precaution procedures. The remaining 175 patients were randomly assigned to one of five groups: the Control group, intervention Beauty group, intervention Emotions Up group, intervention Miscellany group, and intervention Tranquility group. The randomization process was conducted using the Randomizer [We hypothesized that the intervention group, exposed to images of nature, will experience a clinically significant improvement in positive affect and an 80% reduction in negative affect and chemotherapy-related symptoms/adverse events, compared to the control group. To detect a significant difference with 80% power at a 0.05 level of significance (two-sided), we calculated a sample size of at least 30 patients per group.