Background
PATHOGENESIS
Accelerated biological aging, apart from chronological age, is associated with the pathogenesis of chronic morbidities, such as cardiovascular, musculoskeletal, renal, neurodegenerative, and neoplastic diseases [A healthy lifestyle combining a balanced diet including dietary supplements and vitamins, good sleep, and stress management beneficially alters the mAge signatures [The Mediterranean (MED) diet might increase lifespan and improve aging [Measuring polyphenol metabolomics to use as dietary biomarkers is challenging due to several factors: the dependence of polyphenol detection on their chemical structure, the extent of their microbial biotransformation, and the amount ingested [In this study, we examined the effect of a polyphenol-rich and low-red/processed meat diet (Green-MED diet) on 18-month changes in biological age, as measured by mAge using first-, second-, and third-generation epigenetic clocks. We further examined the associations between changes in mAge and dietary intake, including specific urine polyphenols, following 18 months of dietary interventions.