Biochemically validated and self-reported quitting
The total number of validated quitters at 12wks and 26wks was low (12wks: 24/1332 = 1.8%; 26wks: 11/1301 = 0.8%). Compared to VBA, point estimates for validated quit rates were lower in the VBA + LA arm at 12wks (RR 0.78 (95% CI:0.32, 1.89) but higher at 26wks (RR 6.98 (95% CI:1.09, 44.54). In the VBA + CO arm, rates were higher at both 12wks (RR 1.29 (95% CI:0.65, 2.57)) and 26wks (RR 3.11 (95% CI:0.28, 35.10)). However, the confidence interval for all estimates were also wide and included no effect apart from LA at 26 weeks where the point estimate was significant, but confidence intervals were very wide (Table For self-reported quitting, point estimates for quit rates were higher in the VBA + LA and VBA + CO arm in comparison to VBA at 4wks (RR 1.15 95% CI:0.51, 2.59; RR 1.95 95% CI:0.92, 4.10;), 12wks (RR 1.02 95% CI: 0.45, 2.30; RR 1.69 95% CI: 0.73, 3.91) and at 26wks (RR 1.58 (95% CI: 0.74, 3.38; RR 1.41 (95% CI: 0.65, 3.08)). However, these estimates also did not reach statistical significance (Table 