Characterization of pathways enriched for overlap between responses to HSV529 and to vaccines for other pathogens.
(Multi-parameter flow cytometry quantified 70 cell populations which were compared for the same timepoints as the transcriptomic analysis, for all subjects combined. Cell population changes occurring across broad lineages were observed as expected for vaccine responses (The number of genes showing significant changes (FDR corrected p < 0.05) in response to vaccination was higher at 1 day after the first dose of vaccine than at later timepoints and after subsequent vaccine doses (