Ethical approval
The study was conducted after obtaining approval from the Nihonbashi Cardiology Clinic Institutional Review Board (approval number: NJI-021-07-01, approval date: July 27, 2021), in accordance with the principles of the Declaration of Helsinki by the World Medical Association and the ethical guidelines for bioscience and medical research involving human subjects set forth by Ministry of Education, Culture, Sports, Science and Technology, Ministry of Health, Labour and Welfare, and Ministry of Economic, Trade, and Industry. The study protocol was pre-registered with the Clinical Trials Registry System (UMIN-CTR) (UMIN 000045050).