Visual Abstract
atherosclerosis
RHEUMATOID ARTHRITIS, DISEASE, ATHEROSCLEROSIS
Published online Jul. 20, 2023.
Macrophages play an important role throughout the body. Antiinflammatory macrophages expressing the macrophage mannose receptor (MMR, CD206) are involved in disease development, ranging from oncology to atherosclerosis and rheumatoid arthritis. [Macrophages are important throughout the body. They play a regulatory role in inflammatory processes and can adopt various activation states. Although a binary M1–M2 macrophage activation paradigm has long been used, we now know that complex macrophage subtypes exist in vivo (In oncology, tumor-associated macrophages vary from being proinflammatory or immunostimulatory and antitumoral to being immunosuppressive and protumoral (Today, the presence of antiinflammatory macrophages can be assessed by histologic examination of biopsy specimens, limiting the assessment to only a few lesions and small areas within lesions. The development of an anti-CD206 radiotracer would enable noninvasive and whole-body detection of CD206 expression in patients through molecular imaging, allowing different disease sites to be evaluated in a single procedure (Previous efforts in radiotracer development to visualize CD206 expression have mainly focused on the use of mannosylated compounds, because these are naturally binding to CD206. However, mannosylated tracers, such as 2-deoxy-2-[Here, we report on a phase I trial to assess this 