Discussion
infection, Porphyromonas, ATL, inflammation
INFECTION, INFLAMMATION, INFLAMMATION
In this study, we examined the effect of aspirin on the secretion of IL-1β, PGE2, and ATL cytokines in periapical lesions before and after aspirin administration. The study showed that the systemic administration of 80 mg of aspirin at one week decreased the levels of the IL1β and the PGE2 while increased levels of ATL, therefore the null hypothesis is rejected.We collected periapical tissue fluid in the root canal with a paper cone to investigate the secretion of cytokines from the lesion. In the past, periapical lesions were sampled using invasive methods that had the disadvantage of not being followed longitudinally [Inflammation is a vital biological process triggered by infection or injury that plays a crucial role in the immune system’s defense mechanism. Its purpose is to restore tissue homeostasis by initiating a series of reactions that eventually lead to the resolution of inflammation and the restoration of normal tissue function [In recent years, pro-resolving mediators have gained attention due to their active role in inflammation [[IL-1β and PGE2 levels were lower in the aspirin-treated group than in the control group. Reduction of PGE2 due to suppression of Cox-2 pathway by NSAIDs seems reasonable and has been shown in several studies. Also, in a study of murine air pouch infected with Porphyromonas gingivalis, the use of stable analogues of LXA and ATL alone reduced PGE2 in cellular exudates [