Cytokine/chemokine’s level
CYTOKINE STORM
Cytokine storm, featuring elevated cytokine and chemokine levels in serum, has a crucial role in the aggravation of COVID-19. We measured the serum level of 16 cytokines/chemokines, including IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-1ra, MCP-1, IL-15, IL-7, MIP-1β, IP-10, TNF-α, IL-17A, IL-2Rα, and IFN-γ; the results are shown in Supplementary Tables Forest plot of cytokine level changes from baseline (log10). The levels of cytokine/chemokines were converted to logarithmic form before statistical analysis and presented in the form of mean (95% CI). The paired t-test was used to compare the cytokine level at each time point with baseline in each groupCompared with the placebo group, the serum levels of 12 cytokines/chemokines decreased in all the meplazumab groups at multiple visit time points, among which 6 cytokines/chemokines were in the 0.12 mg/kg group, 10 in the 0.2 mg/kg group, and 10 in the 0.3 mg/kg group. Six kinds of cytokines/chemokines were in the 0.12 mg/kg group, 9 kinds in the 0.2 mg/kg group, and 6 kinds in the 0.3 mg/kg group showed decreased tendency from day 2 to day 29. The 0.2 mg/kg dose significantly reduced the IL-4 levels on day 2 (Compared with the baseline, the IL-8, IL-15, IL-2Rα, IFN-γ, and MCP-1 levels in the meplazumab groups declined significantly on days 8 and 9 (