Introduction
memory or cognitive impairment, cognitive impairment, MCI, Alzheimer's disease, AD, cognitive, executive, and memory functions
ALZHEIMER'S DISEASE
Alzheimer's disease (AD) is an irreversible degenerative disease of the central nervous system. Mild cognitive impairment (MCI) is considered the prodromal stage of AD, mainly manifested as memory or cognitive impairment (However, there is a lack of high-quality evidence to support the efficacy of drug interventions in patients with MCI (As MCI causes several intricate neurophysiological abnormalities, comprehensive rehabilitation may be more effective in treating patients with MCI. Recent systematic evaluations support the efficacy of non-invasive brain stimulation (A meta-analysis of Tai Chi, a traditional Chinese aerobic exercise, showed a positive effect on improving global cognitive, executive, and memory functions in patients with MCI (Transcranial direct current stimulation (tDCS) is increasingly used as a non-invasive brain stimulation technique to promote functional brain rehabilitation (Therefore, we hypothesized that Tai Chi combined with tDCS is beneficial for improving the cognitive function of patients with MCI; however, no targeted studies have confirmed the effect of Tai Chi combined with tDCS on improving the cognitive function of patients with MCI. Therefore, we designed a randomized controlled trial to evaluate the effect of Tai Chi combined with tDCS on cognitive function in patients with MCI.