Discussion
anemia
ANEMIA, OXIDATIVE STRESS
The aim of this cohort study was to assess whether transfusion of a blood product containing HbA or HbF to preterm neonates with anemia was associated with a different oxygen delivery. Our observations suggest that the Hb type was associated with cerebral tissue oxygenation. Repeated transfusions in preterm neonates may cause a progressive and untimely displacement of HbF by HbA, and low HbF levels have been found to be associated with poorer outcome.First, we found that the HbF reservoir was associated with crSOThe second relevant finding of the present study was the possible contribution of HbF in restoring cerebral oxygenation in parallel with the anemia correction. As expected, both A-RBCs and CB-RBCs were associated with an increase of crSOIn addition to shedding new light on the response of cerebral parenchyma to PRBC transfusions, these findings may have important clinical implications. Oxidative stress is increasingly recognized as a pathogenic factor for morbidity in preterm neonates without adequate antioxidation capacity.