Symptoms and Clusters at Day 14
myalgia, coronavirus disease 2019 convalescent, fatigue, loss of taste, fever, diarrhea, loss of smell, vomiting, cough, headache, coronavirus disease, Coronavirus Disease 2019 Symptoms, shortness of breath
On day 14 of follow-up, >70% of participants reported ≥1 symptom. Participants in the control and CCP groups each had a median of 2 symptoms (IQR, 0–4) (Prevalence of Coronavirus Disease 2019 Symptoms and Clusters on Day 14Abbreviations: CCP, COVID-19 convalescent plasma; COVID-19, coronavirus disease 2019.Cluster 1 included fatigue, shortness of breath, headache, and/or cough; cluster 2, neurologic symptoms, loss of smell, and/or loss of taste; and cluster 3 (affecting the ability to return to work), any fever, any shortness of breath, grade 2+ fatigue, any diarrhea, grade 2+ headache, grade 2+ myalgia, and/or any vomiting.Using the silhouette method, we identified 2 clusters as the optimal number of clusters to minimize intracluster variation for the k-means cluster analysis (The severity of all cluster 1 symptoms decreased from day 0 to day 14 for participants in both groups. There were no significant differences between treatment groups in the change in severity from day 0 to day 14 for cough (Severity of cluster 1 symptoms in both treatment groups at days 0, 5, 7, and 14. Numbers within bars indicate the number of participants experiencing a symptom, by severity level. Abbreviation: CCP, coronavirus disease 2019 convalescent plasma.