Introduction
tuberculosis
DRUG-SENSITIVE TUBERCULOSIS, RECURRENCE, TUBERCULOSIS
There were an estimated 10·6 million new cases of tuberculosis globally in 2021.National guidelines recommend daily fixed-dose combination therapy to treat drug-sensitive tuberculosis, consisting of 2 months of isoniazid, rifampicin, pyrazinamide, and ethambutol, followed by 4 months of isoniazid and rifampicin. Treatment adherence is considered important for cure and reducing recurrence of tuberculosis.A major component of the directly observed treatment short-course strategy, introduced in China in 1992 and with national coverage by 2005, is directly observed therapy, defined as direct observation of treatment usually by a health-care worker or treatment supporter, to help improve medication adherence. However, a systematic review of treatment support using studies from China showed that only 20% of patients had directly observed therapy by a health professional and more than 50% of patients were self-administering treatment.
