3.1.3. MASLD and MASLD + Fibrosis
fibrosis
FIBROSIS
Once the phenotypes for MASLD and MASLD + fibrosis were established, we aimed to identify the differences between MASLD and MASLD + fibrosis. The heatmap showed that children with MASLD + fibrosis had higher concentrations of methionine, leucine, glycine, alanine, proline, arginine, phenylalanine, ornithine, citrulline, carnitine, AC5:1, medium-chain acylcarnitine (AC6, AC8, and AC10:2), AC18, ALT, AST, and GGT than children with only MASLD (The PLS-DA discriminated into two clusters (