Subject terms
cancers, endometrial carcinomas
CANCERS, ENDOMETRIAL CARCINOMA
Netrin-1 is upregulated in cancers as a protumoural mechanismWe describe netrin-1 upregulation in a majority of human endometrial carcinomas and demonstrate that netrin-1 blockade, using the anti-netrin-1 antibody NP137, is effective both in a mouse model and in patients with endometrial carcinomas.