Introduction
intrabony defects, chronic inflammatory disorder, bleeding, Periodontitis
BLEEDING, STILL, PERIODONTITIS, PERIODONTITIS, SECONDARY, PLAQUE, CHRONIC INFLAMMATORY DISORDER
Periodontitis is a chronic inflammatory disorder, associated with dysbiotic plaque biofilms, resulting untreated in progressive destruction of the tooth-supporting apparatus and intrabony periodontal defects [The osteoinductive demineralized freeze-dried bone allograft (DFDBA) harbors a variety of growth/differentiation factors, notably bone morphogenetic proteins (BMPs) 2, 4, and 7, and is inferred to promote periodontal repair/regeneration, with significant PPD-reduction, CAL-gain, and bone fill [Still, limited data is available on the clinical potential of I-PRF in combination with DFDBA in treating intrabony defects. The present randomized controlled trial assessed for the first time the clinical and radiographic outcomes of I-PRF combined with DFDBA in the management of periodontal intrabony defects in patients with stage-III periodontitis. Clinical attachment level (CAL; primary outcome), periodontal probing depth (PPD), gingival recession depth (GRD), full-mouth plaque scores (FMPS), full-mouth bleeding scores (FMBS), radiographic linear defect depth (RLDD), and bone fill (secondary outcomes) were assessed at baseline, 3, 6, and 9 months post-surgically.