4. Discussion
injury of the liver, ischemia, hepatic ischemia reperfusion injury, hepatic ischemia reperfusion
ISCHEMIA, INFLAMMATORY RESPONSES, PATHOLOGICAL PROCESSES, VEIN OCCLUSION
Clinically, one of the major challenges to successful partial hepatectomy is ischemia reperfusion injury of the liver, and it is urgent to seek for new noninvasive methods to alleviate hepatic ischemia reperfusion injury [The mechanism of hepatic ischemia reperfusion injury caused by hepatic portal vein occlusion during partial hepatectomy is relatively complex and mainly involves ROS accumulation, cell apoptosis, inflammatory reactions, and other pathological processes, which seriously damages the normal physiological function of hepatocytes [Ischemic preconditioning has been confirmed to be a safe and efficient method with potential protective effect on organs recently. Studies have confirmed that ischemic preconditioning can protect liver function in hepatic ischemia reperfusion injury by inhibiting hepatocyte apoptosis, inducing autophagy, or activating related signaling pathways [Oxidation reaction and inflammatory responses are surely activated in hepatic ischemia reperfusion injury [