Study design and population
myocardial damage, gastrointestinal cancer, chronic kidney disease, abnormal liver function, hypermagnesemia
ATRIOVENTRICULAR BLOCK, GASTROINTESTINAL CANCER, HYPERMAGNESEMIA, PRIMARY HYPERPARATHYROIDISM, HYPERALDOSTERONISM, ALLERGY TO MAGNESIUM SULFATE
This study was approved by the Ethics Committee of the Deyang People’s Hospital on January 26, 2022 (No. 2022–04-009-K01). This single-center, double-blinded, prospective, randomized study was registered with China Clinical Trial Registration on 10/11/2021 (ChiCTR2100053073). All male patients were enrolled between March and September 2022, and each patient provided written informed consent before entering the trial.Patients scheduled for elective laparoscopic radical gastrointestinal cancer surgery during March ~ September 2022 were screened through the surgery scheduling system of Deyang People’s Hospital. Eligible patients were 18–70 years old, American Society of Anesthesiologists (ASA) physical status I to III, scheduled for elective laparoscopic radical gastrointestinal cancer surgery (including Gastric surgery, Right Hemicolectomy, Left Hemicolectomy, Sigmoidectomy, and Rectal surgery) using 14 or 16 French (Fr) Foley catheters inserted. Then, we were extubated in the operating room. Patients were excluded if they had hypermagnesemia risk (chronic kidney disease, primary hyperparathyroidism, hyperaldosteronism, and abnormal liver function), contraindications (myocardial damage, atrioventricular block, and allergy to magnesium sulfate) and taking medications known to interact with magnesium sulfate (lithium intake). Elimination criteria were changing to operation method, stay in ICU after the operation, and the first indwelling catheter was failure.