Protocolized volume expansion at diagnosis of HUS might reduce the severity of the subsequent clinical course
HUS
CONTRACTION
Based on data suggesting that volume contraction at presentation with HUS is a risk factor for poor outcomes, Ardissino et al. developed a systematic approach to the management of newly presenting children with HUS. In a study of 76 children using a pre-post design and a “treat-to-target” approach with a goal of 10% body weight increase from baseline, these authors report that renal replacement therapy (RRT) use decreased from 58 to 26% [