Primary endpoint
SE
In the primary analysis using analysis of covariance (ANCOVA) model, the percentage change from baseline to week 24 in body weight was dose-dependent with mazdutide. The estimated mean percentage change from baseline to week 24 in body weight were −6.7% (SE 0.7) with mazdutide 3 mg, −10.4% (0.7) with mazdutide 4.5 mg, −11.3% (0.7) with mazdutide 6 mg and 1.0% (0.7) with placebo. The estimated treatment difference versus placebo were −7.7% (95%CI: −9.5, −5.9) with mazdutide 3 mg, −11.4% (−13.2, −9.6) with mazdutide 4.5 mg and −12.3% (−14.1, −10.5) with mazdutide 6 mg (