Author contributions
LCM
MLA and LCM conceived and planned the clinical study design. LCM performed the administration of the treatments. MLA and LCM accomplished the participants’ follow-up. MLA collected data. CLS conducted the bone marrow aspirate. AB and GR conducted the participant sedation during bone marrow aspirate. SMB and VS conducted the cell multipotent assessment by flow cytometry. MLA and MEO analyzed the data. MLA interpreted the data. MLA, LTGV and SES did the literature search. AMVB completed the analysis of the EQ-5D questionnaire. OV supervised the study. MLA wrote the manuscript. SMB, VS, SES and ACI critically revised the manuscript final version. All authors approved the final article.