Experimental plan in the cuprizone experiment.
Mice were randomized into different treatment groups: BM-MSC injection group (n = 10), SHED injection group (n = 10), saline injection group (n = 10) and healthy control group (n = 5). Mice in BM-MSC and SHED groups received one million stem cells dissolved in 0.2 ml saline via intraperitoneal injections at day -1, 14 and 21 whereas the mice in the saline group received the same amount of saline through the same administration route. The healthy control group did not receive any injections.