MPB-GT group showed increased number of engrafted clones
To rule out the possibility that the higher transduced cell chimerism observed in MPB-GT patients could be the result of few engrafting clones that rapidly expanded after transplantation, we collected unique IS from PB and BM MNC samples at early (30 days), intermediate (1 year) and late (3 years) phases after GT. In addition, we collected IS from BM CD34+, PB CD3+ and PB CD15+ cells as markers of HSPC, lymphoid and myeloid compartments (Supplementary Table In accordance with the higher VCN detected, we observed a tendency to higher number of IS in MPB-GT group with respect to BM-GT, that became statistically significant at steady-state condition (Fig. 