Limitations
Opening the Wisepill® box does not necessarily imply ingestion of pills. Furthermore, the pillbox can only contain a limited number of pills. That would mean a participant will have to refill it every 2 weeks. Although we can show a possible effect, there are several groups for which the effect will be difficult to extrapolate. One group is those who are not able to read and understand SMS. Later, we may develop an interactive voice response calling system to overcome this problem. In addition, those without a phone will not be able to participate. This will be mitigated by providing them with a simple mobile phone feature. Another limitation is that in the currently proposed study, we will still work with a pre-defined SMS structure whereby participants will receive the same messages over a given period that only intervenes on missed intakes. Messages could be more personalized and tailored by using a learning mechanism that will send messages completely tailored towards the adherence pattern of a participant.