Period 1 efficacy
FOP, HO lesions, AHO, pain
SECONDARY
The prespecified primary end point for efficacy was the effect of garetosmab versus placebo on the TWA of the percentage change from baseline in TLA by PET; TLA is considered proportional to the deposition rate of bone mineral into actively forming HO lesions. The next end point in the hierarchy was to assess the percentage change in the total volume of HO lesions by CT in period 1 relative to baseline. The last end point in the hierarchy was the TWA change from baseline in daily pain due to FOP as measured using the daily NRS over 28 weeks in AHO and AHOC. A full list of secondary and exploratory end points is provided in Supplementary Table 