Acknowledgements
STUART
We thank the patients who took part in the trial; the investigators from 13 recruiting centres and their research staff, including Prof. Jeremy Whelan, Dr. Michael Leahy, Dr. Christine Ingram, and Dr. Michelle Scurr; the staff from the CRCTU, University of Birmingham including Penny Goodby, as well as Dr Siân Lax for contributions to the paper. We would also like to acknowledge the contribution of the Data Monitoring Committee members, Dr John Green, Prof. Nick Stuart and David Ryder.