Outcomes
death
DISEASE PROGRESSION, DISEASE, DISEASE
The primary endpoint was the proportion of patients achieving an objective response according to RECIST version 1.1, which included patients with measurable disease who had a complete or partial response. Secondary endpoints were progression-free survival, duration of response, proportion of disease control, and safety. Progression-free survival was defined as the interval from the start of treatment to disease progression or death for any cause (whichever occurred first) or the last progression-free survival assessment for patients alive without progression. Duration of response was assessed in patients who achieved a response and was defined as the time from the date of the first documented response until the date of documented progression or death from any cause. Disease control was defined as the proportion of patients who achieved complete response, partial response or stable disease. The overall survival was defined as the time from treatment initiation to death for any reason.