Distribution of parameter-sets as a function of Monte Carlo threshold.
In Monte Carlo resampling, we randomly selected 30%, 50% or 70% (i.e., Monte Carlo threshold) of patients with 500 iterations per threshold. In all three threshold choices, we observed bimodal distributions with similar peak values (optimal parameter-sets), indicating that two subtypes were detectable at all three thresholds.(TIF)Click here for additional data file.