Primary outcome
PMBL, allergic rhinitis
ALLERGIC RHINITIS
In both groups, during the grass pollen season, a statistically significant increase and then a decrease in the severity of SAR symptoms expressed on the TNSS and VAS was observed (The severity of nasal symptoms assessed using the total nasal symptom score and visual analogue scale.PMBL, polyvalent mechanical bacterial lysate; TNSS, total nasal symptom score; VAS, visual analogue scale; V1, V2, visit 1 and 2; TC1, TC2, telephone contact 1 and 2; Peak nasal inspiratory flow.PMBL, polyvalent mechanical bacterial lysate; PNIF, peak nasal inspiratory flow; V1, V2, visit 1 and 2.Children taking PMBL during the grass pollen season displayed much less intensity of nasal symptoms of SAR compared to children receiving placebo. The severity of the nasal symptoms of SAR on the TNSS scale was revealed to have a significantly lower impact in the PMBL group vs the placebo group at measuring points TC1 and V2 (p = 0.01, p = 0.009, respectively) (
There were no statistically significant changes in immune variables between V1 and V2 in both groups, and between the groups at both measurement points (Variation in γδT, iNKT and cytotoxic T lymphocytes subsets and cytokines throughout the study period.PMBL, polyvalent mechanical bacterial lysate; V1, V2, visit 1 and 2; MFI, mean fluorescent intensity.The analysis of variance showed no statistically significant interaction of the group with the level of measurement for individual variables, meaning that the two groups do not differ in V1 and V2 for individual variables, and that there are no differences between V1 and V2 in individual groups.Data is presented as mean fluorescent intensity (MFI).The relationship between the Th1-like γδT cells and the severity of allergic rhinitis symptoms expressed in the total nasal symptom score. MFI, mean fluorescent intensity.