Simulation set-up
toxicity
To simulate a phase I clinical trial, experimenter needs to specify the following five categories of variables: (1) the total number of patients After specifying the aforementioned variables, we generate a continuous toxicity response We assume that the scale of the continuous toxicity response We experiment with two dosing strategies, accelerated and standard dosing strategies. To that end, we set the values of the homogeneity constant To summarize, the following are the variables we set for the simulation experiment:Number of patients: Variables specific to accelerated designs: Variables specific to standard designs: Variables describing the degree of non-linearity of dose-toxicity curve: Variables shared in accelerated and standard designs: Under the above specification, a patient shows DLT if the patient’s toxicity response 