Markers of insulin sensitivity and phenotypic flexibility during dietary challenges
intra-abdominal adipose, weight loss
INSULIN SENSITIVITY
There was no significant difference in fasting glucose, insulin, HOMA IR, or HOMA %β during the 12 wk intervention between the WLG and the WMG in the OGTT (Fasting and mean postprandial values for glucose, insulin, HOMA-IR, Β-cell function, and the Matsuda Index fasting and postprandial parameters from OGTT and MMTT testsMMTT, mixed-meal tolerance test; WLG, weight-lowering group; WMG, weight-maintaining group. Values expressed mean and standard error and delta change from baseline. Between-subject effects reported in tables were assessed using ANCOVA with post values as dependent variables, type of intervention as a fixed factor (0 = weight loss, 1 = maintenance), and baseline data as a covariate.In our present study, we confirm previous observations on the relationship between body composition and markers of insulin sensitivity, although the study population primarily included normoglycemic individuals according to WHO definitions [Associations between markers of insulin sensitivity with adipose tissue and plasma glucose and insulin levels before the weight-loss intervention. (A) Pearson correlations of different markers with isoleucine. (B) Pearson correlations of different markers with leucine. (C) Pearson correlations of different markers with glutamate. (D) Pearson correlations of different markers with serine. The area under the curve data were derived from OGTT. Data were Log-transformed. Abbreviations: IAAT, intra-abdominal adipose tissue; NASAT, nonabdominal subcutaneous adipose tissue. 