Methods
MSSA
INFECTIOUS DISEASES, SESSION, BACTERIAL RESISTANCE
PREVIOUS PRESENTATION. These data were presented in part in abstract 04905 at Session 182: Late Breaking Clinical Trial Data, at the European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) on July 10, 2021, held virtually.We studied 83 cardiac-surgery patients with nasal Methicillin-susceptible In a large, randomized, controlled study comparing topical, nasal mupirocin versus placebo for a variety of surgical procedures, mupirocin prophylaxis decreased the rate of Although not a formal indication, mupirocin is used as a topical antibiotic prior to surgery for nasal decolonization of MSSA and MRSA, worldwide.Exeporfinium chloride (XF-73) is a dicationic porphyrin derivative with rapid potent bactericidal properties and a low propensity for engendering bacterial resistance.In this multicenter, randomized, placebo-controlled, phase 2 study, we assessed the effect of nasal XF-73 versus placebo on Patients were randomized (1:1) to receive 0.2% (w/w) XF-73 or color-matched placebo as 3 doses (ie, the primary end point), 1 dose immediately before cardiac surgery, and a fifth dose after surgery (ie, 5 doses in total). Of the 5 doses, 4 were administered <24 hours prior to surgery. Destiny staff trained research staff in nasal swab collection and dose administration; nasal swab cultures were obtained just prior to the next application of XF-73 or placebo by research staff. All nasal swabs were analyzed in a central laboratory within each country and the same techniques were followed in all laboratories. Nasal swabs were plated onto BBL ChromAgar plates. S. The primary end point of interest in this study was change in 