Main
DDR, ATM, ataxia telangiectasia-mutated, cancer alterations
DNA DAMAGE
The DNA damage response (DDR) is indispensable for the maintenance of genomic integrity and cell survival. Loss of specific components of the DDR machinery results in distinct forms of genomic instabilityIn preclinical and early clinical studies, ATR inhibition has been shown to be synthetically lethal with LOF of the ataxia telangiectasia-mutated (ATM) kinaseMultiple ATR inhibitor (ATRi)-sensitizing cancer alterations have been proposed by means of RNA interference-enabled or CRISPR–Cas9-enabled forward chemogenomic screening