Conclusion
PJI
In conclusion, mNGS had a significantly higher positivity rate than culture in detecting PJI, suggesting that mNGS may be a promising tool for rapid aetiological diagnosis of PJI, especially in PJI patients with a negative culture result or history of antibiotic administration. However, our data suggest that antimicrobials should be discontinued more than 3 days prior to sampling to further increase the positivity rate of mNGS for PJI.