Duration of response
HGG, death, MM, tumor
DISEASE PROGRESSION, TUMOR, MINIMAL RESIDUAL DISEASE, GIST
Among responders, the duration of response (DoR) was defined as the time from complete response (CR) or partial response (PR) (ATC, BTC, LGG, HGG and ASI); CR with and without minimal residual disease or PR (HCL); or stringent CR, CR, PR or very good PR (MM) to disease progression or death. By investigator assessment, the median (95% confidence interval (CI)) DoR was 14.4 (7.4, not reached (NR)) months for ATC; 8.9 (5.6, 13.7) months for BTC; 7.7 (NR, NR) months for ASI; NR (5.5, NR) months for LGG; 31.2 (7.4, 44.2) months for HGG; and 11.1 (5.6, NR) months for MM cohorts. By independent radiology assessments, the DoR was 13.6 (3.8, 39.4); 10.4 (4.6, 14.9); 7.5 (7.4, NR); 19.4 (3.8, NR); and 13.6 (4.6, 26.7) months in the ATC, BTC, ASI, LGG and HGG cohorts, respectively. In the HCL cohort, median DoR was NR. The patient in the GIST cohort did not have a CR or a PR. Kaplan–Meier plots for DoR based on investigator and independent radiology assessment across tumor cohorts are shown in Extended Data Fig. 