2.6. Interventions
pain
Icatibant (30 mg) and placebo (saline, 3 mL) will be subcutaneously injected in a defined order in a crossover manner. Dermal pain induced by thermal load will be assessed before and after administration of both drugs. For blinding, study participants wear an eye mask when receiving the drugs. The investigator will ensure that the study participant has properly donned the eye mask before preparing the drugs and giving them to the participants. After the used syringes are discarded, the participant will be allowed to remove the eye mask. The study will be conducted over 3 consecutive days under hospitalization.