2.5. Combined test of transcriptomic and WES data
We computed a gene-based score, and its associated p-value, by combining the results of the differential gene expression analysis (To assign equal weights to the 2 experiments into the combined statistic, we rescaled the p-values derived from the LCL expression analysis to have the same range as the p-values calculated from the WES data, before converting them to Z-scores. We used Bonferroni correction for multiple testing.