Longitudinal markers of immune response
Two types of measurements were available at each visit: 1) anti-spike binding IgGs, measured in BAU/mL) neutralization titers of sera provided in In brief IgGs markedly increased after each dose, but rapidly declined over time, with a rate that did not substantially differ after the second or the third dose (A: longitudinal evolution of the binding antibody concentration of anti-S IgG. B-C-D: longitudinal evolution of the neutralizing activity against VoCs after the first (B, see 