CONSORT Diagram
Patients were screened by acute care clinicians from the affiliated centers, mainly the departments of neurology and neurosurgery. Numbers of screened patients were not recorded in all affiliated hospitals (eTable 2 in Of 287 included patients, 197 (68.6%) were female, and the median (IQR) age was 55 (48-63) years. A total of 287 randomized patients were analyzed according to the intention-to-treat principle, with 144 in the lumbar drain group and 143 in the standard of care group (