Conclusions
gastritis, atrophy
INTESTINAL METAPLASIA, GASTRITIS, ATROPHY, EROSIVE OESOPHAGITIS
In this 3-year interim analysis comparing the long-term safety of vonoprazan and lansoprazole as maintenance therapy in patients with healed erosive oesophagitis, pathological examination of gastric biopsy specimens showed no neoplastic/dysplastic alteration of epithelial cells, no gastric NETs, no exacerbation of gastritis, no development of atrophy, and no intestinal metaplasia. Approximately 80% of enrolled patients received treatment with vonoprazan or lansoprazole for at least 3 years. A further interim analysis is planned at week 204, with the final analysis occurring at week 260.