Conclusion
obesity, inflammation, reduced abdominal obesity, cardiometabolic disease, abdominal obesity
OBESITY, INFLAMMATION
In people with obesity at risk of developing cardiometabolic disease, the low-calorie diet improved MetS-Z, abdominal obesity, and inflammation marker hsCRP. After one year, intervention with exercise further reduced abdominal obesity, liraglutide treatment further reduced MetS-Z and abdominal obesity, and liraglutide combined with adherent exercise further reduced MetS-Z, abdominal obesity as well as hsCRP compared to placebo. The combination treatment thereby reduced all outcomes compared to placebo, potentially providing the largest risk reductions of future cardiometabolic disease in an adult population with obesity.