Ethics
This prospective, single-centre sponsor-initiated study was conducted in healthy volunteers at the University Medical Centre Groningen. The protocol was approved by the Medical Ethics Committee Brabant (dr. Deelenlaan 9, 5042 AD Tilburg, The Netherlands, chairperson: Prof. dr. E.G. Schouten on November 18th, 2020 NL75041.028.20/P2043) and the study was registered at clinicaltrials.gov (October 6th, 2020 NCT04584788). The manuscript was written in accordance with the STROBE reporting guidelines [