Feces
Weighed aliquots of selected fecal homogenates from TP2 were pooled in proportion to total sample weight for each human subject to include the majority of excreted radioactivity. The time range of the pooled fecal homogenates varied from 24 to 120 h postdose, among subjects, depending on the rate of radioactivity excretion. Radioactivity of the pooled fecal homogenates was determined by LSC. Each pooled fecal homogenate was extracted twice with methanol/ammonium formate pH 3.0 and the resulting two supernatants were combined, evaporated, and reconstituted in methanol/water (1:3). Sample preparation recovery of radioactivity was determined by LSC prior to subsequent quantitative radio‐HPLC analysis.