Expected treatment-related adverse events
liver irradiation, musculoskeletal and connective tissue disorders, toxicity, mediastinal disorders, hepatitis, autoimmune pneumonitis
ADVERSE EVENTS, DISORDERS, MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDER, METABOLISM AND NUTRITION DISORDERS, HEPATITIS, GASTROINTESTINAL DISORDERS
The possible toxicity of a combination of radiotherapy and immunotherapy mainly depends on the location of the irradiation and may involve hepatitis for liver irradiation or autoimmune pneumonitis for lung irradiation. However, such side effects are transitory and manageable. In a phase I study, administration of SBRT before immunotherapy appeared safe with acceptable toxicity. The most common treatment-related adverse events were general disorders and administration site abnormalities. Other frequent mild adverse events (> 20%) included gastrointestinal disorders, metabolism and nutrition disorders, musculoskeletal and connective tissue disorders, and respiratory, thoracic, and mediastinal disorders [