Acknowledgements
The authors thank the patients, their families and all investigators involved in this study. Analysis of imaging data was provided by the central imaging vendor, BioClinica. Medical writing assistance and editorial support, under the direction of the authors, was provided by A. Riaz, R. Dunn and M. Bipath of Prime funded by Regeneron Pharmaceuticals according to good publication practice guidelines. The sponsors were involved in the study design and collection, analysis and interpretation of data, as well as checking data provided in the manuscript. The authors had unrestricted access to study data, were responsible for all content and editorial decisions and received no honoraria related to the development of this publication.