Plasma folate
SE
REGRESSION
In adjusted analysis, at 4 weeks, mean plasma folate was higher in the DTG arm than in SOC (difference [DTG‐SOC] 1.6 ng/ml, 95% CI 0.8, 2.3; Difference in change in plasma folate and red blood cell mean cell volume from baseline, and cross‐sectional red blood cell folate and serum vitamin B12 at ≥96 weeks, in the DTG arm compared to the SOC armAbbreviations: CI, confidence interval; DTG, dolutegravir; MCV, mean cell volume; RBC, red blood cell; SE, standard error; SOC, standard‐of‐care.Normal ranges: plasma folate 3.89–26.8 ng/ml [Normal regression adjusted for first‐ versus second‐line. Change in plasma folate and MCV were also adjusted for baseline value.Normal regression also adjusted for first‐ versus second‐line, availability of routine resistance testing, NRTI backbone, and site, date of sample and time from sample taken to analysis (plasma folate, RBC folate and vitamin B12 only), and baseline value (for plasma folate and MCV).Change in plasma folate from baseline to week 4 and week ≥96. CI, confidence interval; DTG, dolutegravir; SOC, standard‐of‐care.