Conclusion
hand deformities, RP, pain
ADVERSE EFFECTS, DIGITAL ULCERS
Our study has proven that when combined with conventional medical therapies, the administration of fat micrografts enriched with the ADSVF into the hands of patients with SSc can significantly improve pain without adverse effects. Studies with larger numbers of patients are necessary in order to confirm that this method can improve the number of digital ulcers, RP, digital perfusion, vascular density of the nail bed, and the function of the hand. Based on the aforementioned findings, the regenerative medicinal benefits of the ADSVF may be an essential aid for rheumatologists and plastic surgeons before or during the treatment of hand deformities in patients with SSc.