Discussion
CAD
CAD
We investigated the significance of the ACE I/D genotype for pre-training exercise capacity and whether the ACE I/D genotype impacts the outcome of 12 weeks of whole-body high-intensity interval training on exercise capacity in patients with stable CAD. The pre-training exercise capacity was independent of the ACE genotype. The applied low-volume high-intensity exercise protocol efficiently improved exercise capacity in the ACE D/D, ACE I/D and ACE I/I genotype groups, but the magnitude of improvements was similar between groups. Thus, our findings indicate no interaction between the ACE I/D genotype and pre-training exercise capacity and exercise capacity trainability in patients with CAD.