Introduction
intestinal reduction, circulationFolate
SECONDARY
Human milk provides optimal nutrition for infants and has many established health benefits for both the mother and childExclusively breastfed infants rely on human milk to meet their micronutrient needs (with the exception of vitamin D drops)Upon ingestion, folic acid must be reduced to the metabolically active form (5-MTHF); however, the capacity for intestinal reduction is limited, resulting in unmetabolized folic acid (UMFA) entering systemic circulationFolate is transported across the mammary epithelium via the folate binding protein (FBP), folate receptor alpha (FRα)Prenatal vitamins containing an analogue of natural folate [(6This study was a secondary analysis in a randomized clinical trial and aimed to evaluate the impact of supplementation with 0.6 mg/day folic acid or an equimolar dose (0.625 mg/day) of (6