Supporting measures used to validate the EoE-IQ
dysphagia, EoE, stomach pain, chest pain, throat, pain
DYSPHAGIA, EOSINOPHILIC ESOPHAGITIS, DIFFICULTY SWALLOWING, EOE
Four EoE-related PRO measures were used in the psychometric evaluation of the EoE-IQ: the Patient Global Impression of Severity (PGIS), the Patient Global Impression of Change (PGIC), the EoE-SQ, and the DSQ (Additional file The PGIS is a single-item questionnaire evaluating patients’ difficulty swallowing food over the past week on a 4-point scale (0 = None to 3 = Severe), with lower scores indicating lower symptom severity. The PGIC is a single-item questionnaire evaluating patients’ overall change in difficulty swallowing food since beginning study medication on a 7-point scale (0 = Very much better to 6 = Very much worse), with lower scores indicating greater improvement in difficulty swallowing food.The EoE-SQ measures frequency and severity of EoE symptoms other than dysphagia and pain with swallowing during the past 7 days: chest pain, stomach pain, burning feeling in the chest, food or liquid coming back up into the throat, and throwing up. Frequency is rated on a 5-point scale (1 = Never to 5 = More than once a day) and severity on an 11-point numeric rating scale (0 = No symptom to 10 = Worst possible symptom) for each symptom. EoE-SQ Frequency scores are calculated as the sum of responses to 5 items and thus range from 5 to 25, with higher scores indicating higher frequency of symptoms. EoE-SQ Severity scores are calculated as the sum of the responses to 3 items (chest pain, stomach pain, and burning feeling in the chest) and thus range from 0 to 30, with higher scores indicating more severe symptoms.The DSQ is a 4-item questionnaire evaluating the daily frequency and severity of dysphagia associated with EoE [Clinical measures assessed in R668-EE-1774 included the peak esophageal intraepithelial eosinophil count and the Eosinophilic Esophagitis Endoscopic Reference Score (EoE-EREFS) (Additional file 