Introduction
Sarcomas, sarcomas
ALVEOLAR SOFT PART SARCOMA, SARCOMAS, MALIGNANT TUMORS, SOFT TISSUE SARCOMA, SARCOMAS, STS
Sarcomas constitute a heterogeneous family of malignant tumors, generally derived from mesoderm that exhibit a different behavior across distinct subtypes. Even though targeted therapies have emerged for some rare sarcomas such as alveolar soft part sarcoma,Patients with advanced sarcomas still represent a poor prognostic population, exhibiting a median of overall survival (OS) that has increased above 18 months in recent phase III trials for soft tissue sarcoma (STS) patients,Early cell-cycle control proteins, involved in the G1-S transition, such as D cyclins and cyclin-dependent kinases (CDK) 4 and 6, are frequently dysregulated in different sarcomas.In preclinical studies, we found that the best predictive biomarker for palbociclib efficacy was 