2.7. Statistical Analysis
PBC
A per-protocol analysis was performed with participants who demonstrated at least 80% adherence to the study. To describe the study population, a univariate analysis was performed with percentages and Pearson’s chi-squared test. For frequencies less than 5, Fisher’s Exact Test was applied. In addition, a group mean analysis was carried out using repeated-measures ANOVA (evaluating time, treatment, and time x treatment); the assumptions were verified, and when they were not met, transformations were carried out using the Box–Cox procedure. The analyses were done in the RStudio 4.0, 2021 program interface (Posit PBC, Boston, BSA, USA). 