Endpoints
hypotension, AUT
HYPOTENSIVE EPISODE
Primary endpoint is time weighted average of area spent under 65 mmHg for MAP per patient (AUT - depth of hypotension below a MAP of 65 mmHg × time spent below a MAP of 65 mm Hg divided by procedure duration in minutes) of AUT (TWA-AUT).Secondary endpoints are AUT, number of hypotensive episodes (defined as MAP < 65 mmHg for at least 1 min) during the procedure and cumulative duration of hypotension during the procedure.Volume of i.v. fluids (ml/kg/h) and norepinephrine (mcg/kg/min) administered in the operating theater, urine output (ml/kg/h), postoperative arterial blood pH, arterio-venous CO