Distributions of cognitive development categories (patients younger than 6 years of age)
In the subpopulation of patients younger than 6 years of age at phase 2/3 baseline, cognitive categories were defined for 25/28 and 12/12 patients in the idursulfase-IT and no idursulfase-IT groups, respectively, at 1 year, and for 25/28 and 11/12 patients in the early idursulfase-IT and delayed idursulfase-IT groups, respectively, at 2 years (Additional file Results for this subpopulation were similar to those for the overall population (Fig. Distribution of, and patient movement between, cognitive categories in the subpopulation aged < 6 years. Graph depicts the movement of individual patients from their cognitive category at 1 year to their cognitive category at 2 years; the width of each band corresponds to the number of patients who changed cognitive category with that movement. At 2 years, the proportions of patients in the different cognitive categories were more similar in the two treatment groups than at 1 year, with no statistically significant difference in category distributions between groups (