Evaluation of microcirculation
TVD, PVD
PVD
No differences in microcirculation flow and density parameters were found between the groups at the beginning of the study. TVD and PVD did not change significantly over the course of the study. However, PPV 6 h after the beginning of the trial was significantly higher in patients receiving ascorbic acid (89.7 (82.5–93.3) %) compared with placebo (79.9 (73.5–86.4) %, p = 0.041) (Fig. 
PPV changes in ascorbic acid and control groups throughout the studyAA—ascorbic acid; PPV—proportion of perfused small vessels; * p < 0.05 between groupsData are presented as median and 25th and 75th percentiles
MFI changes in ascorbic acid and control groups throughout the studyAA—ascorbic acid; MFI - microvascular flow index of small vessels;Data are presented as median and 25th and 75th percentiles