PD-1 signaling inhibited proliferation of malignant T cells.
LYMPHOMA, TUMOR PROGRESSION
To explore the mechanisms underlying malignant T cell activation and tumor progression upon PD-1 blockade, we evaluated PD-1 expression in lymphoma tissue samples. scRNA-Seq and flow cytometric analysis of PBMCs isolated from the patient before treatment showed PD-1 expression on malignant T cells (Previous studies have reported that the PD-1 signaling pathway functions by inhibiting the PI3K/AKT and PKCθ/NF-κB signaling pathways, inhibiting activation of transcription factors like activator protein 1 (AP-1) and nuclear factor of activated T cells (NFAT) and activating phosphatase and tensin homolog deleted on chromosome 10 (PTEN) in T cells (