Randomization and blinding
MUSCLE RELAXATION
Random grouping: This study adopts a randomized double-blind controlled trial. The experimental subjects were randomly divided into three groups by anesthesiologist A who did not know the experimental plan using statistical software SPSS 26.0(IBM Corporation, USA): ROC1 group (1 ED95 group: 0.3mg/kg rocuronium), ROC2 group (2 ED95 group: 0.6mg/kg rocuronium), and ROC3 group (3 ED95 group: 0.9mg/kg rocuronium). And anesthesiologist A put the grouping and drug configuration information into opaque envelopes. Double-blind design: Before anesthesia induction, anesthesiologist A who did not know the experimental plan opened the random grouping envelope in the drug preparation room to determine the corresponding number of patients in each group, extracted the drug into a 10ml syringe and labeled the drug name, and handed it over to the surgical researcher in the operating room for intravenous injection preparation for patients. The anesthesiologist responsible for anesthesia operation, experimental data recording, postoperative follow-up, and the patients in the experiment were unaware of the specific grouping situation. Unblinding plan: If the patient suspects that the muscle relaxation effect during operation leads to the inability to IONM, unblind emergency will be performed by opening the random grouping envelope and administering 2-4mg/kg sugammadex sodium injection (Patheon Manufacturing Services LLC, USA) according to the dose of rocuronium.