Abbreviations
EGCG, (-)-Epigallocatechin-3-gallate; LC-ESI-MS/MS, liquid chromatography-electrospray ionization ion-trap tandem mass spectrometry; GnRHa, gonadotropin-releasing hormone analog; OPLS-DA, orthogonal partial least squares discriminant analysis; VIP, Variable importance in the projection; HMDB, Human Metabolome Database; SMILES, simplified molecular-input line-entry system; CTD, Comparative Toxicogenomics Database; KEGG, Kyoto Encyclopedia of Genes and Genomes; PPI, protein–protein interaction; 3D, three-dimensional; HPGA, hypothalamic-pituitary-ovarian axis; GnRH, gonadotropin-releasing hormone; IGF-1, insulin-like growth factor 1; mTOR, Mammalian target of rapamycin; ER, estrogen receptor; ERK2, extracellular signal-regulated kinase 2.