Structural and functional connectomic profiles
multiple basal ganglia and limbic areas
CORTEX
The PPN has connections with the cerebral cortex, multiple basal ganglia and limbic areas, the thalamus, other brainstem regions, the spinal cord, and the cerebellum. These connections implicate the PPN in a variety of functions including movement, cognition, and sleep. With respect to cortical connectivity, dense projections exist between upper extremity regions of the motor cortex, followed by the lower extremity, trunk, and orofacial regions [In adult cats, skilled locomotor performance was disrupted by lesions to motor cortical areas, including M1, S1, and parietal cortices [