Statistical analysis
death
REGRESSION
The mean length of hospital stay in the control group of BeeCovid study was 12.6 days with a standard deviation of 6.5 daysThe main analysis of the study was conducted under the intention-to-treat principle. The modified intention-to-treat population consisted of all patients who were randomized and received either EPP-AF or placebo.The primary outcome of the study was defined as length of hospital stay from randomization to 28 days if the patient remained hospitalized after that period. Additionally, if the patient did not survive hospitalization, length of hospital stay was considered as equal to 28 days, even when death occurred less than 28 days after randomization. Data from patients who could not be reached to complete the 28-day follow-up were censored at hospital discharge. The between-group comparison was evaluated by generalized additive models assuming beta-binomial distribution, with adjustments by stratification variable (baseline type of oxygenation) and had 95% confidence intervals.Secondary outcomes, such as the need for dialysis and mortality, were evaluated by logistic regression models and presented relative to chance with respective 95% confidence intervals. Continuous outcomes were described by means and standard deviations and compared by generalized regression models with distributions that best fit the data. More details are provided in the study protocol