Ethics
The protocol was approved by the LSTM Research ethics committee (reference: 17-078), by the National Institute for Medical Research (NIMR)/Ministry of Health Ethics Committee (reference: NIMR/HQ/R.8a/Vol.IX/2916), by the Tanzania National Research Ethics Committee and by the Tanzania Medicine and Devices Authority. All participants provided written informed consent to participate in the study. This trial is registered with the International Standard Randomised Controlled Trial Number (ISRCTN) registry (