Results
hemorrhage, PROPPR
HEMORRHAGE
The PROPPR Trial randomized 680 patients (338 in the 1:1:1 cohort vs 342 in the 1:1:2 cohort) with 546 (80.3%) male patients, a median (IQR) age of 34 (24-51) years, a median (IQR) Injury Severity Score of 26 (17-41), a total of 330 (48.5%) with penetrating injury, and a total of 591 (87.0%) with severe hemorrhage. Baseline characteristics between the 2 cohorts failed to demonstrate any differences and have been previously published elsewhere.The primary outcomes from the original PROPPR Trial frequentist analysis failed to demonstrate any significant differences in 24-hour and 30-day mortality between the 2 resuscitation strategies. At 24 hours, the 1:1:1 cohort displayed a 12.7% mortality rate compared with a 17.0% mortality rate within the 1:1:2 cohort (difference, −4.2% [95% CI, −9.6% to 1.1%]; risk ratio [RR], 0.75 [95% CI, 0.52 to 1.08]; Within this bayesian analysis, the probability that a 1:1:1 resuscitation was superior to a 1:1:2 strategy with regards to 24-hour mortality was found to be 93% (RR, 0.72 [95% CrI, 0.45-1.11]) (