Data collection and study endpoints
bleeding, aneurysm, endocarditis, stroke, Loeys-Dietz syndrome, MFS
BLEEDING, MYOCARDIAL INFARCTION, ANEURYSM, ENDOCARDITIS, POSTOPERATIVE COMPLICATIONS, STROKE, LOEYS-DIETZ SYNDROME, ASCENDING AORTIC DISSECTION
From both databases, patients with CTD (MFS, Loeys-Dietz syndrome and ACTA2 mutations) undergoing elective surgery for aortic root aneurysm <60 mm diameter with at most mild AR (grade 0/4 or 1/4) were extracted. Patients with ascending aortic dissection or endocarditis were excluded. The primary endpoint was mid-term survival. Secondary endpoints were in-hospital mortality and the occurrence of postoperative complications (reintervention for bleeding, myocardial infarction, need for coronary revascularisation, stroke, perioperative dissection). Secondary endpoints during follow-up were the occurrence of type A and type B dissections, freedom from valve reintervention, freedom from valve or aortic intervention (ascending aorta and arch) and freedom from AR grade ≥2/4.