Introduction
critically ill, ill
CRITICALLY ILL
Intermittent or bolus enteral feeding regimens in critically ill patients have been of increasing interest to clinicians and scientistsCritically ill patients lose 2–3% of muscle mass each day as a result of decreased muscle protein synthesis and unchecked protein breakdownHowever, it has been speculated that other less well-explored benefits of intermittent feeding might improve patient outcome or experienceWe hypothesise that intermittent enteral feeding may modulate amino acid, fat and carbohydrate metabolite profiles over time, when compared to continuous feeding. For example, alterations in amino acid trafficking may be advantageous as a result of addressing the muscle full effect, providing support for future trials combining intermittent feeding with a co-intervention addressing bioenergetics failure to improve physical function