Participant timeline
LIVER FIBROSIS
The patients will be followed up for 24 weeks (Fig. Study timeline. ICR, intermittent calorie restriction; SOC, standard of careThe schedule of enrollment, interventions, and assessmentsFollow-up at 12 weeks (end of treatment) will include the following mandatory tests: assessment of liver fat by MRI-PDFF, liver fibrosis by magnetic resonance elastography (MRE), anthropometrics, body composition analysis (BCA), visceral adipose tissue (VAT), food intake, quality of life (QOL), liver metabolites, microbiome, and hormones (leptin, adiponectin, ghrelin, GLP-1, apelin, and osteopontin). Follow-up will be terminated at the end of the maintenance period (24 weeks), and anthropometrics, BCA, VAT, food intake, and QOL will be assessed. All study participants, except those who withdraw consent for the study, will be followed up for the study period.