2.3. Clinical and Biochemical Evaluation
NAFLD, fatty liver, TG
RENAL, FATTY LIVER
At baseline and after 6 months of treatments, subjects underwent clinical assessments and laboratory tests, including body weight, waist circumference, systolic blood pressure (SBP), diastolic blood pressure (DBP), ultrasound examination of the carotid arteries and endothelial function. Fasting blood glucose was collected and fasting glycemia, glycosylated hemoglobin, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), were measured. Renal function was assessed by serum creatinine levels and estimation of the glomerular filtration rate was performed. Hepatic enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST), and γ-glutamyltransferase (GGT) were also measured. The AST/ALT ratio was calculated as the ratio between the concentrations of the enzymes AST and ALT. The fatty liver index (FLI) was used as a marker of NAFLD, which was calculated as previously described [