Statistical analysis
Due to the nonindependence and unknown distribution of data associated with an up-down sequential allocation method, the exact sample size needed for a prespecified precision of the estimation of EDStatistical analyses were performed using SPSS (version 25.0, IBM Corp., Armonk, NY, USA). Data were presented as the mean ± standard deviation (SD), the median (interquartile range, IQR), or the number (proportion) as appropriate. Values for ED