Data source and analysis population
amnestic MCI
DISEASE
The psychometric evaluation of the ADCS-ADL-MCI was undertaken using data from the ADCS ADC-008 trial, a 36-month, multicenter, randomized, double-blind, parallel-group, placebo-controlled study in subjects with amnestic MCI [The science of evaluating an instrument’s measurement properties does not consider the biological mechanism of the underlying disease process and is agnostic as to the reasons why patients are in the evaluated disease state. As such, disease experiences as viewed through clinical measures and patient-reported outcomes resulting from treatment are considered equally usable to non-treated natural history patients (i.e., the instrument is applicable across the disease continuum). The psychometric evaluation of the ADCS-ADL-MCI was thus performed on all randomized subjects in the ADC-008 dataset for whom the ADCS-ADL-MCI was measured (