Continuous glucose monitoring results
No statistically significant differences were noted in terms of CGM indicators such as MBG, SDBG, LAGE, PPGE, MAGE, MODD, TIR, breakfast AUCpp, lunch AUCpp, and dinner AUCpp among the three groups during the screening and lead-in period (P>0.05). Compared to the screening period, the MBG, SDBG, LAGE, PPGE, MAGE, MODD, TIR, breakfast AUCpp, lunch AUCpp, and dinner AUCpp indicators of all three groups showed significant improvements during the lead-in period (P<0.05; CGM results.*represents P < 0.05(comparison between screening and lead-in period for each group,matched-samples Student’s t- test).#represents P < 0.05(comparison between lead-in and after 12-week treatment period for each group,matched-samples Student’s t- test).CGM results Changes in MBG Compared with those during the lead-in period, the Ins+Met and Ins+SZ-A groups showed significant improvements in terms of MBG, SDBG, LAGE, PPGE, MAGE, TIR, breakfast AUCpp, lunch AUCpp, and dinner AUCpp after the 12-week treatments (P<0.05); there was no statistically significant difference observed in MODD (P>0.05). None of these indicators improved significantly in the Ins group (P>0.05). After 12 weeks of treatment,the MBG, SDBG, TIR,breakfast AUCpp, and lunch AUCpp indicators of the Ins+Met and Ins+SZ-A groups showed significantly greater than those of the Ins group (P<0.05).In addition, the LAGE, PPGE, MAGE, and dinner AUCpp levels of the Ins+SZ-A group were lower than those of the Ins+Met nd Ins groups (P<0.05). However,there were no statistically significant differences in MODD among the three groups (P>0.05; 