Safety parameters
proteinuria, diarrhea, hyperlipidemia
HYPERLIPIDEMIA, PERIPHERAL EDEMA, THROMBOCYTOPENIA, OF DELAYED WOUND HEALING, ADVERSE EVENT, EVENTS
Twenty-one patients on sirolimus presented at least one adverse event: 10 had proteinuria > 0.5g, nine had thrombocytopenia, seven had hyperlipidemia and 13 had peripheral edema. None of these events required temporary or definitive discontinuation of study medication during the conversion. Four patients interrupted sirolimus because of delayed wound healing and diarrhea in the second and third years. There was no development of 