Pharmacokinetic analysis
Dosing regimen (using median dose) for the current study was used to obtain simulated concentration-time data and corresponding profiles of L-citrulline using R (version 4.1.0) via package “linpk”. Parameter values for clearance, volume of distribution and absorption rate constant were obtained from a previous study and were fixed at 0.6 L/h, 0.9 L and 0.95, respectively [