Participant Characteristics
HELLP, PROM, chorioamnionitis, cord clamping, hemolysis
PROLONGED RUPTURE OF MEMBRANES, HEMOLYSIS, EPP, CHORIOAMNIONITIS
Abbreviations: DCC, delayed cord clamping; EPP, extrauterine placental perfusion; HELLP, hemolysis, elevated liver enzymes, and low platelet count; PROM, prolonged rupture of membranes.Intention-to-treat set.In the intervention group EPP was feasible in 24 of 24 singletons and in 3 of 5 second twins. In 1 twin pair, EPP was not feasible because the second twin’s placenta was attached to first twin’s placenta; the procedure was switched to DCC according to the study protocol. In the other case of twin birth, the attending obstetrician opted for immediate cord clamping in both infants due to severe chorioamnionitis and maternal instability. In the control group, DCC was performed as randomized in 24 of 25 singletons and 5 of 5 twin births. In 1 case, the placenta was accidentally detached during cesarean delivery before birth, and thus the infant received EPP instead of DCC.The intention-to-treat analysis revealed no significant difference in the primary outcome. In the EPP group, the mean (SD) hematocrit level was 56.0% (1.8%) compared with 53.9% (1.8%) in the DCC group (MD, 2.1 percentage points [95% CI, −2.2 to 6.4 percentage points]). Subgroup analyses by gestational age, sex, and mode of pregnancy also showed no significant differences (