Authors’ contributions
DM, MP, MM
MP and MC conceived, planned, finalised, and wrote the statistical analysis plan, with review by JT, EC, and FP. MP and MC wrote the manuscript with a review by DM. DM, in collaboration with FP, GM, and MM, led the study conceptualization, design, and application for funding; MM is the grant holder. DM manages the trial. FP, GM, and DM are responsible for all medical and neurological and neurophysiological issues that arise during participant screening, intervention delivery, and follow-up. EC and FC provide leadership in the design and implementation of the BCI technology; JT provides leadership in the design and implementation of the advanced biosignal (EEG-EMG) processing; AB provides advice on neuropsychology and behavioural evaluation and participates in study participant evaluation; FTamburella and ML provide advice on the functional motor evaluation and participate in study evaluation of participants. FTomaiuolo is responsible for neuroimaging data analysis. DM, FP, GM, MM, and MP contributed to the statistical plan of the study. FS, MP, FP, and EM developed the REDCAP template for data collection and trial monitoring. FS is REDCap Administrator for Istituto Superiore di Sanità, Rome, Italy. DC is an IT system administrator at Istituto Superiore di Sanità, Rome, Italy. MP generated the randomization list. DM was the clinician responsible for the randomization assignment at FSL. MM is the chief investigator of the Promotoer project. DM is the clinical lead of the Promotoer study. MP is the senior statistician responsible. All authors have read and approved the final manuscript.