Vaccine-elicited human antibodies N751-2C06.01 and N751-2C09.01 neutralize HIV strain BG505
VIRUS
We further characterized the purified antibodies for neutralization activity and found that the antibodies N751-2C06.01 and N751-2C09.01 (named for donor-lineage.clone, hereafter referred to as 2C06 and 2C09) neutralized both BG505 and a version of BG505 virus with glycan at residue 611 missing (BG505.N611Q), found to be especially sensitive to fusion-peptide-directed antibodies (We used SPR to measure the binding of the antigen-binding fragments (Fabs) of 2C06 and 2C09 to BG505 DS-SOSIP trimer. Both bound tightly, with K