16. Discussion
death, nerve injury, ischemia, brain damage, TBI, ischemia-reperfusion injury
ISCHEMIA
Based on the results of the present study, remote ischemic preconditioning (RIPC) has the potential to significantly enhance the 6-month prognosis for individuals with severe TBI. Furthermore, we discovered that RIPC can reduce NSE levels and plasma S-100β levels, which serve as indicators of nerve injury. Moreover, it resulted in a decrease in both the duration of hospitalization and the associated costs. Multiple studies have indicated that in patients with TBI, the levels of serum NSE were found to have a significant inverse correlation with GCS scores, this suggests that it can serve as a crucial indicator for assessing brain damage.RIPC involves intermittent ischemia and reperfusion of the distal organ to protect the target vital organ from subsequent lethal ischemia-reperfusion injury, and several organs and illnesses have been tested for RIPC.TBI, one of the most crucial issues in public health, has a profound impact on the lives of those who are injured and their families, and it is linked to a considerable rate of death.Here are a few of the constraints that were identified in the study. The findings may not be extrapolated as this research was a trial that was randomized and controlled, conducted at a single center. Another constraint is that we solely conducted a follow-up for 6 months, potentially necessitating an evaluation of long-term results. The study is limited by the small number of participants. To further investigate the clinical outcome of RIPC treatment in severe TBI patients, additional multicenter randomized controlled trials will be required in the future.