Authors’ contributions
J.G.H. carried out the experiments and wrote the first draft of the manuscript; K.A., M.B., and R.H. provided consultations and contributed to the writing of the manuscript. S.M. contributed to the study methodology and statistical analysis of the data. Z.S.A. and R.S.K. contributed to the experimental works. J.R. conceptualized the work and M.D. provided the clinical consultations and study conceptualization. All the authors read and approved the final manuscript.