Analyses of secondary outcomes
REGRESSION, SECONDARY
A secondary analysis will fit the same model to the 180-day outcome measured at the 12-month timepoint to assess durability. Further secondary analyses will explore temporal patterns of number of days of risky opioid use. In addition, a mixed effects negative binomial model will be fit including treatment by time interactions for each timepoint. The model will include participant random intercepts to account for correlation in responses arising from multiple observations for each patient participant.Analyses for Aim 2 secondary outcomes will be analyzed with mixed effects regression models with treatment by time interactions (analogous to those described above for the primary outcome) or generalized linear models with generalized estimating equations (GEE) to account for correlation of responses will be fit. Similar regression models will be fit for the Aim 3 objectives, but these will use provider participant rather than patient participant as the unit of observation.