Introduction
dementia
SEPARATION
At a population level, interventions that delay the onset of dementia by 2 y are predicted to reduce the number of dementia patients by 20% [Investigations in model systems add validity to the prospective cohort evidence. Furthermore, they provide insights into the molecular and physiological mechanisms underlying long-chain ω-3 PUFAs and FLAVs which suggest that they could confer additive and potentially synergistic effects. Indeed, DHA supplementation increases its availability for neuronal membrane synthesis, neurite outgrowth, and neurogenesis and promotes synaptic plasticity [However, randomized controlled trials that have intervened with either EPA/DHA or flavonoids are conflicting, with many showing marginal or no meaningful cognitive benefits [The primary efficacy endpoint was hippocampal dentate gyrus-sensitive cognitive function, assessed by the number of false-positives on the Picture Recognition Task of the Cognitive Drug Research (CDR) computerized assessment system. The latter is analogous to the classic pattern separation paradigm, which is highly dependent on hippocampal function [