Study population
tumor, cutaneous melanoma
REGRESSION, TUMOR, DISEASE, CUTANEOUS MELANOMA, ULCERATION, ONCOLOGY
To perform an ITC, patients with stage IIIB-C cutaneous melanoma who were enrolled in EORTC 18,071 and CheckMate 238 were included in this analysis, as they were the common population of the two trials (EORTC 18,071 and CheckMate 238 excluded patients with stage IV and stage IIIA disease, respectively). Inverse probability treatment weighting (IPTW) was used to balance key baseline characteristics between the participants in both trials. In order to generate a weight for each patient, age, sex, Eastern Cooperative Oncology Group performance status (ECOG PS), time from surgical resection to randomization, disease stage at baseline, tumor ulceration status, lymph node involvement (macroscopic/microscopic), and baseline lactate dehydrogenase (above or below the upper limit of normal [ULN]) were included in a logistic regression model, with enrollment in CheckMate 238 as the dependent variable. Stabilized weights, which preserve the original sample size in the weighted population [