Outcome measures of RAML and SEGA
SEGA, rAML, haemorrhage, tumour, SEGA lesions, RAMLs
HAEMORRHAGE, TUMOUR, COMPLICATIONS
We investigated the change in the size of rAML (largest lesion and mean diameter change of largest lesion in both kidneys) from baseline to the last imaging and the change in SEGA volume from baseline to the last imaging. RAMLs with the longest diameter (LD) in both kidneys and overall were identified. The change in size was calculated by subtracting the LD at baseline from the LD at the last imaging. The baseline was defined as imaging closest to the start of treatment. The change in size was defined according to RECIST [SEGA volume was calculated by manually drawing areas along tumour borders on every axial slice (1 mm slice thickness), summing areas and multiplying the result with the slice interval (usually 1 mm), performed on a PACS workstation (SECTRA PACS software). For every exam, a T1-weighted isotropic volume series (MPRAGE) was used, contrast enhanced when available, and alternatively without contrast.The effectiveness of everolimus treatment for rAML (> 1 cm) and SEGA lesions was investigated when imaging was available and when everolimus was prescribed for these indications. The quality of renal imaging was defined as good, moderate, or poor.We further investigated the change in the number of rAML > 1 cm and renal complications (haemorrhage, embolization, nephrectomy) during everolimus treatment.