Author contributions
HZ designed and implemented the study. YW, JX, XQW, BZT, PR, GMW, collected and processed the trial data. CXH, MHZ, LF, QG, YS pretreatment of blood samples. JZ, RFS were responsible for the quality control of the study. JXD, YYX, wrote the article. BYL, YZD provided valuable comments on the analysis and writing of the article. The authors read and approved the final manuscript.