Author contributions
RECRUITMENT
RL is the lead Investigator. NJ-H, DH, FC, CP, BR and RL were responsible for the conceptualisation and design of the study. DC, AR, DG, RW, RH, DS, MS-B, SS, LD, LC, MC, DC, VK, AA, NA, GH, DW, RM, FL, AW, RH, JE, AO, AE, MK, DP, KN, JB, ZS, AR, GW, VK and NS contributed to participant recruitment and sample collection. AR contributed to the collation of data and sample transfer. DH, GP, CP and BR were responsible for experimental analysis and interpretation. RL, DC, AR, HK, DG, RW, RH, DS, AG-M and AM were responsible for oversight of the conduct of the trial. FC was responsible for statistical analysis. NJ-H, DH, CP, BR and RL were responsible for drafting the manuscript. All other authors reviewed and approved the final manuscript.