Modelling analysis
In addition to the study protocol, we will also carry out a Mathematical MultiState-transition Markov Model to perform long-term cost-effectiveness extrapolation. It will be used in order to extend the time horizon (to a life-time horizon) and to extrapolate the intermediate outcome parameters (e.g., OS and DFS) to outcome parameters (e.g., mortality). Sources will be this trial and a systemic literature review on the outcome parameters as well as the costs from the baseline and beyond the trial horizon. The model design will be a Markov Multistate Cohort Model [