Effect of minocycline treatment and suicidal ideation on KYN pathway changes
ideation, suicidal ideation
Considering the increased baseline KYN/TRP for patients with suicidal ideation, we tested whether in these patients, study arm and baseline suicidal ideation influenced KP longitudinal changes. KYN/TRP appeared to overall decrease by week 4 in those with baseline suicidal ideation (from 0.14 ± 0.10 to 0.12 ± 0.08). However, we found no significant effect of study arm on such changes (Repeated measures analysis of variance with log transformed KYN/TRP.In participants with suicidal ideation, the KYN/TRP slightly decreased in the minocycline group versus placebo, but without statistical significance.KYN: kynurenine; TRP: tryptophan.