Statistical analysis
According to our preliminary research results, the incidence rate of ≥ 2 grade RD in the control group is 65.6%. We estimated that approximately 102 patients would need to be randomized in a 1:1 ratio, with 51 patients in each group. This is to detect a difference in the incidence rate of ≥ grade 2: 65.6% in the control intervention group vs. 36.0% in the Sanyrene group. The estimation assumes a power of 80%, a two-sided significance level of 0.05, and an anticipated dropout rate of about 8%. An interim analysis was performed when reaching approximately half the sample size, the O’Brien–Fleming type boundary (alpha of 0.003) was used for early trial stoppage.Baseline characteristics of patients were displayed in the intention-to-treat trial populations (see the Fig. 
CONSORT Diagram