Sensitivity analyses
REGRESSION, SECONDARY
Considering that the condition of the patients deteriorates over time, as a sensitivity analysis, two imputation methods for the missing data were proposed for the primary variable (ADAS-Cog11) and secondary variable (CIBIC+). The methods were as follows (1) regression analysis and (2) analysis with the worst response (missing values were considered as “non-responder” with an increase in the value of the initial score by 5 and 10 units for ADAS-Cog11 at 24 and 48 weeks, respectively, and 7 units for CIBIC+).