1. Introduction
hypertension
HYPERTENSION
The use of garlic (A wealth of evidence exists to demonstrate that lowering blood pressure can substantially reduce premature morbidity and mortality [Several studies have shown that garlic can help lower blood pressure in individuals with hypertension [Aged black garlic (ABG) is a type of modified garlic that contains a unique composition of organosulfur compounds and polyphenols compared to fresh garlic [In this sense, this study aimed to evaluate the antihypertensive effects of a daily intake of a low-dose SAC-optimized ABG extract for 12 weeks in individuals with Grade I hypertension following blood-pressure-reducing drug therapy. For that purpose, a randomized, triple-blind, placebo-controlled parallel trial was developed, where the primary outcome was the reduction in office and home blood pressure. Secondary outcomes such as endothelial function, nitric oxide, inflammatory cytokines, angiotensin-converting enzyme activity, and antioxidant capacity levels in blood were determined to explain the antihypertensive effect of ABG.