Implications
MDD
This study has raised several implications at the clinician, health system, policy and research levels. Ketamine warrants exploration in future definitive studies, evaluating its role in the symptomatic treatment of MDD with or without typical antidepressants when prognoses are extremely short. Screening and assessment of MDD in the palliative care setting using ultra-short questionnaires (e.g. PHQ-2) and Endicott Criteria might be feasible, and may be further investigated [