Discussion
hypertensive
Our study demonstrated a significant, inverse association between plasma Se and the subsequent risk of renal function decline in hypertensive patients. Furthermore, folate was a significant modifier for the relation of plasma Se and renal function. The inverse association was more pronounced in participants receiving folic acid treatment or with higher baseline folate levels (i.e., ≥9.0 ng/mL). However, it should be noted that given the existing sample size, the positive findings of the interaction test could be due to chance.