Statistical analysis
ATRIAL FIBRILLATION, HEART
For the primary endpoint, safety analyses will be performed based on the intention‐to‐treat principle. A per‐protocol basis analysis will also be performed as a supplemental analysis. When noninferiority is demonstrated on the primary endpoint, the superiority hypothesis will also be evaluated. An asymptotic method based on the normal distribution will be used to compare the rate of SCEs by brain MRI 1–3 days after CA of AF.Other categorical variables will be presented as absolute and relative frequencies and compared using a chi‐square test or Fisher's exact test. Continuous variables will be presented as the mean ± standard deviation for normally distributed data or median with the interquartile range (25th–75th percentiles) for skewed data and analyzed with the Student's A Patient characteristics at baselineAbbreviations: AF, atrial fibrillation; CRT‐D, cardiac resynchronization therapy defibrillator; CRT‐P, cardiac resynchronization therapy pacemaker; ICD, implantable cardioverter defibrillator; INR, international normalized ratio; LA, left atrium; LV, left ventricle; NYHA, New York Heart Association.The CA procedure and complicationsAbbreviations: 3D, three‐dimensional; ACT, activated clotting time; CA, catheter ablation; CB, cryoballoon; LA, left atrium; MRI, magnetic resonance imaging; RF, radiofrequency.