Target engagement
FXR target engagement was confirmed at week 6 by dose-dependent increases in fibroblast growth factor 19 (FGF19) levels and decreases in 7α-Hydroxy-4-cholesten-3-one (C4) levels with tropifexor 60–200-µg doses compared with placebo. The LS geometric mean ratio of FGF19 postdose (at 4 h) to predose and the LS geometric mean ratio of C4 at end-of-treatment to baseline have been summarized in Extended Data Table 