Discussion
MDD, TRD
This RCT found that the antidepressant effect of 20 mg/d of adjunctive simvastatin for 12 weeks did not differ from the effect of placebo in Pakistani adults with TRD. To our knowledge, this is the largest RCT of adjunctive statins in MDD to date and the first in TRD. In a meta-analysisHowever, our negative results are congruent with an RCT