Progression free survival by investigator and independent radiology assessment across tumor cohorts.
HGG, glioma, MM
MULTIPLE MYELOMA, DISEASE PROGRESSION, BILIARY TRACT CANCER, HAIRY CELL LEUKEMIA, DISEASE, GLIOMA, ANAPLASTIC THYROID CANCER, ADENOCARCINOMA OF SMALL INTESTINE
Efficacy evaluable population: Primary and expansion cohorts in all except low grade glioma and MM which is primary analysis cohort; (A) Investigator assessment (B) Independent radiology assessment. ATC: By investigator assessment in 36 patients, 21 (58%) patients had disease progression and six (17%) had died without disease progression. Nine (25%) patients were censored due to end of follow-up. By independent radiology review, progression of disease was observed in 26 (72%) patients and three (8%) patients died without disease progression. Seven (19%) patients were censored due to end of follow-up. BTC: By investigator assessment in 43 patients, 33 (77%) patients had disease progression and six (14%) patients had died without disease progression. Four patients were censored due to end of follow-up. By independent radiology review, progression of disease was observed in 27 (63%) patients and five (12%) patients died without disease progression. Eleven (26%) patients were censored due to end of follow-up. ASI: By investigator assessment in three patients, one patient (33%) had disease progression. Two (67%) patients were censored due to end of follow-up. By independent radiology review, progression of disease was observed in three (100%) patients. LGG: By investigator assessment in 13 patients, six (46%) patients had disease progression. Seven (54%) patients were censored due to end of follow-up. By independent radiology review, progression of disease was observed in nine (69%) patients and one (8%) patient died without disease progression. Three (23%) patients were censored due to end of follow-up. HGG: By investigator assessment in 45 patients, 38 (84%) patients had disease progression. Seven (16%) patients were censored due to end of follow-up. By independent radiology review, progression of disease was observed in 36 (80%) patients and four (9%) patients died without disease progression. Five (11%) patients were censored due to end of follow-up. HCL: By investigator assessment in 55 subjects, six (11%) patients had disease progression and three (5%) patients had died without disease progression. Forty-six (84%) patients were censored due to end of follow-up. MM: By investigator assessment in 10 patients, nine (90%) patients had disease progression. One patient was censored due to end of follow-up. ASI, adenocarcinoma of small intestine; ATC, anaplastic thyroid cancer; BTC, biliary tract cancer; G, grade; HCL, hairy cell leukemia; HGG, high (WHO G3/G4) grade glioma; LGG, low (WHO G1/G2) grade glioma; MM, multiple myeloma; WHO, World Health Organization.
