Inflammatory, proteomic and metabolomic CSF profiling
Of 46 tested cytokines, chemokines and growth factors, 17 remained below the detectable range at baseline and after the transplantation (CCL4, CCL11, EGF, G-CSF, IFN-y, IL-1b, IL-5, IL-7, IL-12p40, IL-12p70, IL-17, IL-22, LIF, PDGF-AB, PDGF-BB, RANTES and TGF-B3). We performed a principal component analysis (PCA) on all the detectable analytes evaluated at baseline and 3 months after transplantation; the first two principal components (PC1 and PC2) represent the main axes of variation within these data and explained 30.1% and 19.9% of variation, respectively, for the low-dose group (Fig. 