Introduction
Smoke, emphysema
HEART DISEASE, DISEASE, EMPHYSEMA, LUNG CANCER, HEAT, DISEASES
Cigarette smoking is a cause of serious diseases including lung cancer, heart disease, and emphysema, and is a leading cause of preventable deathsIn 2001 the US Institute of Medicine issued the report ‘Clearing the Smoke’, in which it was proposed that ‘For many diseases attributable to tobacco use, reducing risk of disease by reducing exposure to tobacco toxicants is feasible’Heated tobacco products (HTPs) in general electrically heat tobacco to temperatures significantly lower than those which cause pyrolysis and combustion in combustible cigarettesReductions in toxicant exposure and ensuing changes in disease risk in smokers switching to using HTPs have been well described in the literature. However, despite the importance of nicotine delivery, along with positive subjective effects, in providing an acceptable alternative to cigarettes for adult smokers and therefore in supporting THR, much less is known about the delivery of nicotine from commercially available HTPs. The Pulze Heated Tobacco System (HTS)