Ethics approval and consent to participate
DER
The study complies with the principles laid down in the Declaration of Helsinki and has been approved by the ethics committee of the Medical Association Berlin (Berlin—Ethik-Kommission der Ärztekammer Berlin). The reference number is Eth-27/10, it has been retrospectively registered at the WHO-approved registry German Registry for Clinical Trials (Deutsches Register Klinischer Studien, DRKS), trial registration number DRKS00013335 on 27/11/2017. Written informed consent has been obtained from all patients prior to study enrollment.