Why was this study done?
non-syndromic CRC, colorectal cancer, CRC, adenomas
COLORECTAL CANCER, ADENOMAS
The risk of colorectal cancer (CRC) is 3 to 4 times higher in first-degree relative (FDR) of patients with non-syndromic CRC. These individuals are considered candidates for colonoscopy-based screening starting at 40 years of age, but this approach is associated with a suboptimal acceptance rate of approximately 50%.Recent evidence suggests that annual fecal immunochemical testing (FIT) may be equivalent to colonoscopy for detecting CRC and advanced adenomas, but the acceptance of this strategy is unknown in the familial-risk population.This study was designed to test the hypothesis that the uptake of FIT screening is superior to the uptake of colonoscopy screening in this population, with an equivalent effect on CRC detection.