Conclusion
infections, pain
INFECTIONS
DEXGEL Bone is a moldable, easy-to-apply bone regeneration optimized technology that naturally stimulates bone formation. The addition of DEXGEL to BL® granules provided the biomaterial with injectability without compromising bone volume nor density. DEXGEL Bone even showed a tendency for more new bone formation and maximized primary stability of the dental implant, which have reported a positive correlation. A clinical benefit is therefore achieved: improved granule cohesivity, easier handling, delivering (injectability), and sculpting of the biomaterial within the alveolar socket. DEXGEL Bone did not cause pain, discomfort, or infections, being effective in alveolar ridge preservation. DEXGEL is easy to produce, is cost-effective, has a long-shelf life, and can provide benefits to commercially available grafting materials in terms of injectability, moldability, and clinical performance. This in situ gelling HG further provides a platform for the entrapment of specific therapeutic agents to meet other clinical scenarios. Some conclusions of this study may be limited by a small population size, which however was adequate for the first human safety assessment. Now with safety validation, larger populations could be considered in the future.
