Conclusions
perspiration, HFSR
The suppression of perspiration with aluminum chloride may prevent progression to grade 3 regorafenib-related HFSR and prolong the time to HFSR development. However, since many subjects in the present study discontinued the treatment during the 12-week study period, further studies enrolling a larger pool of patients receiving regorafenib and other MKIs are required to determine the efficacy of aluminum chloride in reducing the incidence of treatment-related HFSR.