Background
fatigue, Multiple Sclerosis, disability, non-traumatic
NEUROLOGICAL DISORDER, MULTIPLE SCLEROSIS, DEMYELINATING DISEASE
Multiple Sclerosis (MS) is the most common, non-traumatic, neurological disorder among middle aged adults. Initially characterized as an inflammatory demyelinating disease of the central nervous system, neurodegenerative processes lead to progressive disability during later stages [The definition and conceptualization of fatigue has been changing and expanding for years, including recent updates [Contrary to its impact, pharmacological treatment options for fatigue are limited [We have recently described a group-based exercise training framework for pwMS (multimodal agility-based exercise training [MAT] [In a first step, the present feasibility study was conducted to determine whether all aspects of the trial were implementable in the clinical setting, and to inform the potential progression to a powered randomized controlled trial (RCT). Secondarily, preliminary clinical outcome data was acquired.