Strengths and Limitations
gangrene
DISEASE, GANGRENE
To our knowledge, this is the first model-based simulation economic analysis of the ON101 with GWC vs GWC alone strategies for DFUs. To ensure the applicability of our economic results to the study setting and the health care sector perspective in the Taiwanese context and to reduce heterogeneity arising from multiple data sources for model input parameters, several methodologic efforts were made, including (1) transformation of the health care costs using the cost ratios to reflect local health care systems and practice patterns; (2) utilization of the Taiwanese population-based health utility data to enhance the applicability of study results to the local setting; (3) adaptation of existing validated disease simulation models to include the gangrene state, which was not well considered in previous cost-effectiveness studies,Some limitations to our study should be acknowledged. First, our analysis may underestimate the cost-effectiveness of ON101 with GWC alone because of 2 conservative modeling assumptions. The relative healing efficacy for ON101 vs GWC alone was adopted directly from the ON101 trial, in which ON101 was compared with a commonly used absorbent dressing for standard care, which has a better wound healing efficacy than GWC.