DISCUSSION
Zuranolone, somnolence
BRAIN DISORDERS
Zuranolone is an oral allopregnanolone analogIn this study, the oral administration of zuranolone in capsule form as single (morning) and multiple doses (evening) of 10, 20, and 30 mg was generally well tolerated, regardless of ethnicity or age. The rate of TEAEs for zuranolone 30 mg was 22.2% in Japanese adults, 44.4% in White adults, and 11.1% in Japanese elderly. The most common TEAE observed was somnolence, consistent with previous studies.In this study, Enhancement of low beta‐band power was observed in the EEG assessment for the zuranolone 30‐mg group but not for the 10‐mg group, suggesting that a single 30‐mg dose, but not 10‐mg dose, is sufficient to induce GABAThis study has some limitations. Only male subjects were enrolled in the study although female subjects were eligible. This is important because allopregnanolone likely plays a role in sex differences in susceptibility to brain disorders.