Author contributions
EBB was the principal investigator and had the main responsibility for the clinical trial in which the data was obtained; EBB and LH acquired funding for the present study; EBB, UB, GB, and LH conceived the original idea and made a substantial contribution to the outline and design of the study; AW conducted the statistical analysis and all authors contributed to the interpretation of results; LH was the main author with continuous support from EBB, UB, AW, and GB. All authors contributed to substantially revising the manuscript.