Association Between Mortality and Antidepressant Use After HCC Diagnosis With Different Comorbidities
comorbidity, HBV infection, HCV infection, liver cirrhosis, HCC
DISORDER, LIVER CIRRHOSIS
A subgroup analysis was conducted to examine the use of antidepressants after diagnosis in different comorbidity subgroups. Analyses showed significant inverse associations between postdiagnosis antidepressant use and both overall and cancer-specific mortality in patients with HCC with HBV infection (adjusted HRs, 0.76 [95% CI, 0.75-0.78] and 0.67 [95% CI, 0.60-0.75], respectively), HCV infection (adjusted HRs, 0.92 [95% CI, 0.89-0.94] and 0.86 [95% CI, 0.76-0.98], respectively), liver cirrhosis (adjusted HRs, 0.76 [95% CI, 0.75-0.77] and 0.71 [95% CI, 0.65-0.77], respectively), and alcohol use disorder (adjusted HRs, 0.76 [95% CI, 0.72-0.80] and 0.72 [95% CI, 0.53-0.98], respectively) compared with nonuse (