Dantrolene prevents repolarization abnormalities, normalizes the QT variability, and reduces T-wave heterogeneity
arrhythmias, VT/VF
ARRHYTHMIAS
Detailed analysis of the ECG features revealed how inhibition of the RyR2 leak with DS prevents VT/VF and SCD. QT variability and prolongation are known to have prognostic significance in failing hearts. While prolonged QTc is considered a risk factor for arrhythmias, QT heterogeneity as an add-on is a surrogate for lethal VT/VF (