Clusters and participants
arteriovenous malformation, trauma, tumour, intracerebral haemorrhage
INTRACRANIAL ANEURYSM, INTRACEREBRAL HAEMORRHAGE, SECONDARY, TUMOUR, CEREBRAL INFARCTION
Hospital sites were approached through neurosurgery and neurology professional networks. To be eligible, they either had no or inconsistent protocols for managing abnormal physiological variables in patients with acute intracerebral haemorrhage and had to be willing to implement the required interventional care bundle protocol as part of routine care. Eligible sites needed to enrol consecutive adult (age ≥18 years) patients presenting within 6 h after the onset of acute intracerebral haemorrhage, have a local representative (known as a champion) who was willing to lead the implementation of the intervention, and be able to provide the required study data. Key patient exclusion criteria included the intracerebral haemorrhage being secondary to a structural abnormality in the brain (eg, an arteriovenous malformation, intracranial aneurysm, tumour, trauma, or previous cerebral infarction) or to reperfusion therapy (eg, intravenous thrombolysis or endovascular thrombectomy), or that a patient was unlikely to adhere to the study treatment or follow-up regimen, or both, as judged by the treating clinician. Full details of the inclusion and exclusion criteria are provided in the 