Principal Findings
stroke, depression, anxiety
STROKE
This multicenter RCT sought to investigate the efficacy of a TR nonimmersive VR system on the motor performance and cognitive abilities of patients with SABI compared to a control group undergoing conventional training (URTRs). Our results indicated that both teleneuro-VRRS and control groups improved in global functional, cognitive, and general health status. However, we found that only the teleneuro-VRRS group improved in motor and executive functions, with a significant reduction in anxiety and depression symptoms. These findings confirmed the results of a previous study carried out on patients with stroke [The current literature mostly focuses on the usability and feasibility of TR systems [In a VR environment, exercises favor the development of the knowledge of (1) results of movements and (2) quality of movements (performance) [Another important finding of our study is the more evident reduction in the burden of distress in the caregivers of patients in the teleneuro-VRRS group compared to the control group. This is probably why caregivers were involved during the TR sessions, acting as cotherapists, but received, at the same time, support from a multidisciplinary rehabilitation team for their social, physical, and psychological needs. In fact, remote interventions can be effective in reducing psychological distress, thanks to the active participation in the care and decision-making processes, also avoiding travel difficulties related to access of appropriate health care providers [Lastly, we investigated the usability of the TR system by means of the SUS score, demonstrating that subjects perceived the system as efficient, more satisfying, and easier to use, in line with the literature [