Proportion of participants with no decrease or <5-letter ETDRS letter decrease from baseline BCVA at month 12
INFLAMMATION, DETACHMENT
There was a greater proportion of participants with no decrease from baseline or a decrease of <5 ETDRS letters from baseline in study eye BCVA at month 12 in the high-dose group (Surgical detachment of the fovea is normally associated with a reduction in visual acuity, as is vector-related inflammation. Hence, the finding that the proportions of participants maintaining at least one line (that is, five letters) of ETDRS acuity in both high-dose (83%) and low-dose (71%) groups were numerically greater than in the unoperated control group (68%) does at least support the safety of the gene therapy treatment.