Statistical analyses
SPSS version 26.0 (IBM, Armonk, NY) was used to process and analyze the data. Normally distributed data are expressed by mean (SD) and non-normally distributed data are expressed by Median(interquartile range, IQR). For the comparison of paired measurement data, the paired sample t-test was used for normally distributed data, and the Wilcoxon signed rank test was used for non-normally distributed data. As for the comparison of two-sample measurement data, the two independent sample t-test was used for normally distributed data, whereas the two independent sample Wilcoxon signed rank test was used for non-normally distributed data. The Chi-square test was used to classify data. A p-value <0.05 was considered statistically significant.