Introduction
death, massive damage, infarct, coronary artery occlusion
CORONARY ARTERY OCCLUSION, ACUTE MYOCARDIAL INFARCTION, AMI, ARTICULAR DISEASE, INFARCT
Acute myocardial infarction (AMI) inflicts massive damage leading to coronary artery occlusion and progressive cell death in the infarct regionHuman CD34The postulated mechanism of action by which CD34There is growing evidence suggesting that miRNAs have proangiogenic activitiesThe development of advanced therapeutic medicinal products (ATMPs) for cell transplantation requires a potency assay before commencing the pivotal studies and commercialization of the ATMP. This potency assay should quantitatively measure the relevant biological product attribute, have lot to lot consistency, and be based on the ATMP’s mechanism of action for the particular disease intended to treat. In order to develop a potency assay, we conducted a series of in vitro studies characterizing the growth factor secretion, exosome secretion, gene expression, cell surface markers, differentiation potential, and angiogenic potential of ProtheraCytes clinical batches, which are human autologous CD34