Statistical analysis
gastric cancer
REGRESSION, EVENTS, METASTASIS, GASTRIC CANCER
The primary endpoint was 1‐year survival rate, and recent studies in advanced gastric cancer with peritoneal metastasis showed that the 1‐year survival rate was approximately 70%. The sample size was calculated based on the hypothesis that the experimental regimen's 1‐year survival rate could improve by 15%. A one‐sided, one‐sample log‐rank test calculated from a sample of 43 subjects achieved 90.5% power at a 0.025 significance level to detect a 1‐year survival rate of 85% in the experimental group and the expected number of outcome events was 14 during the study. The loss of follow‐up rate was supposed to be 10%; therefore, a total of 47 patients needed to be enrolled. Survival analysis was performed using the Kaplan–Meier method with a log‐rank test. Univariate and multivariate survival analyses were performed using the Cox proportional hazards regression model to generate a hazard ratio using SPSS (version 23.0, SPSS Institute, USA). Rate calculation and 95% Confidence Interval (CI) were done by the “Hmisc” R package with the Wilson test. In all the statistical tests, P‐values ˂0.05, between each group, were deemed to show a statistically significant difference.