Purpose
non-obese, PCOS
POLYCYSTIC OVARY SYNDROME (PCOS), TYPE 2 DIABETES
Edited by: Julius Hreinsson, Sahlgrenska University Hospital, SwedenReviewed by: Mayank Choubey, New York University, United States; Nicolas Crisosto, University of Chile, ChileThis article was submitted to Reproduction, a section of the journal Frontiers in EndocrinologyFollistatin is a glycoprotein that represses members of the transforming growth factor-β superfamily including activin. Higher follistatin levels have been associated with an increased risk for type 2 diabetes and with polycystic ovary syndrome (PCOS). In non-obese adolescent girls with PCOS, insulin sensitization results in a healthier endocrine-metabolic outcome than oral contraception (OC); we assessed whether those differences are underscored by changes in serum follistatin concentrations.