Background
Ulcerative colitis, chronic disease, UC
RECURRENCE, DISEASE, REMISSION, MUCOSAL INFLAMMATION, ULCERATIVE COLITIS, CHRONIC DISEASE
Ulcerative colitis (UC) is a chronic disease characterized by relapsing and remitting mucosal inflammation of the rectum and colon [Accumulating evidence indicates that endoscopic improvement is associated with better outcomes, including improved long-term remission rates and a decreased risk of colectomy [Several studies have compared long-term outcomes in patients with UC with endoscopic remission (MES 0) and endoscopic improvement (MES of 0 or 1). Patients with a MES of 0 have been shown to have a reduced risk of disease recurrence [Recent advances in the medical management of UC have made endoscopic improvement a realistic goal [Tofacitinib is an oral small molecule Janus kinase inhibitor for the treatment of UC. The efficacy and safety of tofacitinib in patients with UC were demonstrated in two phase 3 induction trials (OCTAVE Induction 1 and 2) and a phase 3 maintenance trial (OCTAVE Sustain) [