Patients
cHCC-CC, intrahepatic lesion, Cancer
METASTASIS, CHCC-CC, PATHOLOGY, DISEASES, CANCER
This is a retrospective study in accordance with the Declaration of Helsinki and was approved by the Institutional Review Board (Approve Number: 2023-E423-01) of our hospital that waived the requirement of an informed consent. From January 1, 2012, to December 31, 2020, a retrospective analysis was conducted on 213 cHCC-CC patients confirmed by surgical pathology in three institutions (The 1st affiliated hospital of Guangxi medical University, People’s Hospital of Guangxi Zhuang Autonomous Region and Guangxi Medical University Affiliated Cancer Hospital). The inclusion criteria for patient selection were as follows: (1) presence of a single intrahepatic lesion; (2) confirmation of cHCC-CC through surgical pathology; (3) negative marginal state of resection after radical operation as confirmed under the microscope (R0); (4) high-quality enhanced CT images were obtained within 1 month; and (5) regular follow-up imaging examinations (such as ultrasound, CT, and MRI.) and laboratory examinations within 1 year after operation. The exclusion criteria included: (1) previous treatment for cHCC-CC before operation; (2) adjuvant therapy and extra-hepatic metastasis after operation; (3) loss to follow-up or died of other diseases during the follow-up; and (4) incomplete CT imaging data. (Fig. The flowchart of the inclusion process. Numbers in parentheses are numbers of patients. After applying inclusion and exclusion criteria, a total of 143 patients were included in the study. Therein, 110 patients from institution 1 (The 1st affiliated hospital of Guangxi medical University) were randomly divided into training set (