INTRODUCTION
CAD, pancreatic cancer
CHRONIC PANCREATITIS, PANCREATIC CANCER, CAD, METASTASES
Distinguishing pancreatic cancer from nonneoplastic masses is critical and remains a clinical challenge. As pancreatic cancer and benign masses, primarily mass‐forming chronic pancreatitis, appear similar in imaging examinations. For patients with pancreatic cancer who do not receive timely diagnosis or present with distant metastases, the median survival is 8–12 months and 3–6 months, respectively.Contrast‐enhanced harmonic endoscopy ultrasonography (CH‐EUS) is a promising technology to distinguish between malignant and benign pancreatic masses.In recent years, computer‐aided diagnosis (CAD) systems have become increasingly sophisticated tools in medical imaging.In this study, we built an auxiliary diagnosis system (CH‐EUS MASTER) onto the main engine of the EUS system in order to identify and track the pancreatic masses dynamically in real time via describing TIC characteristics of each area of the pancreas, identifying points of interest and guiding EUS‐FNA. A single‐center randomized controlled trial was conducted to evaluate whether CH‐EUS MASTER could improve the accuracy of diagnosis for benign and malignant pancreatic masses and improve the diagnostic yield of EUS‐FNA.