Outcome definitions
SECONDARY
The primary outcome is the change in distance (in meters) walked during the 6MWT from baseline to 6 months. The secondary outcomes and time points of their measurement are summarized in Table Overview of the study outcomesThe average daily step count is measured by the hip-worn Actigraph wGT3X-BT accelerometer over a 7-day period and calculated using a proprietary algorithm within the ActiLife software. The non-wear time is detected using the Choi algorithm as implemented in the ActiLife software. In contrast to the trial protocol but in line with the latest recommendations [