Phase 1: CBD patch test outcomes on human skin
allergic reaction, allergic reactions
CONTACT DERMATITIS, CONTACT DERMATITIS, ALLERGIC REACTION
To investigate the possible allergic reactions on the skin (e.g., contact dermatitis) while using CBD oral paste, 100 healthy subjects (50 males and 50 females, 18–65 years old) were recruited to participate in this study. 0.1% CBD was loaded in four Finn Chambers (Epitest, Tuusula, Finland) and placebo (pure oral paste) was loaded in four other chambers. The chambers were applied to the subjects’ skin on the upper back. After 48 h, the chambers were removed and 15 min later, any allergic reaction was scored according to the International Contact Dermatitis Research Group (ICDRG) standards [