Outcomes
AKI, initiation of renal replacement, acute kidney injury
SECONDARY, SECONDARY INFECTION, ACUTE KIDNEY INJURY, KIDNEY DISEASE
The primary endpoint was the time to clinical improvement, defined as the difference in days in length of hospital stay between groups.The secondary outcomes included percentage of participants who needed mechanical ventilation (MV), secondary infection (defined as cultures of blood, urine or tracheal aspirate positive for fungi or bacteria), incidence of acute kidney injury, as well as need for renal replacement therapy, vasoactive drugs, IABP, or ECMO. We have also assessed the mortality rate by 28 days.Acute kidney injury (AKI) was defined according to the Kidney Disease: Improving Global Outcomes (KDIGO) as stage 1 (increase in serum creatinine of 0.3 mg/dl in 48 h or increase in baseline serum creatinine by 1.5 to 1.9 times in 7 days), stage 2 (increase in serum creatinine by 2.9 times in 7 days), or stage 3 (threefold or more increase in serum creatinine in 7 days or initiation of renal replacement therapy).