Author contributions
Conceptualization and Methodology, P.S., N.P., T.S., N.R., D.P., P.P. and J.S.; Subject management and Clinical investigation, P.P.; Method validation, P.S.; Data interpretation and Statistical analysis, P.S.; Writing original draft manuscript, P.S.; Review, N.P., T.S., N.R., D.P., P.P. and J.S.; Supervision, J.S.; Funding Acquisition, J.S.