Introduction
death, cortical ischemic strokes, AIS, acute stroke, disability
ACUTE ISCHEMIC STROKE, ACUTE STROKE
Acute ischemic stroke (AIS) is a leading cause of death and disability across the US and around the world.We performed a first-in-human pilot study of HD C-tDCS as an AIS treatment strategy in patients with acute cortical ischemic strokes who harbored salvageable penumbra. We report the results of our proof-of-concept study, which was designed to assess the feasibility, safety, and tolerability of applying individualized HD C-tDCS in acute stroke emergency settings and explore potential efficacy on imaging biomarkers of neuroprotection and collateral enhancement.