Statistical analysis
REGRESSION
The primary analysis was intention-to-treat analysis. Cumulative incidence of each outcome was estimated with the Kaplan-Meier method. Log rank tests were applied to evaluate differences between groups. We calculated hazard ratios (HR) with 95% confidence intervals (CI) for incidence of clinical outcomes using a Cox regression model. Covariates with SMD ˃ 0.1, which could provide evidence of an imbalance between matched groups, were adjusted for survival analysis. We examined proportional hazards assumption using plots of the log(-log) survival function and Schoenfeld residuals. All 