Sample size estimate
Based on preliminary power analyses (see below), we plan a 36-month intervention period that includes a 90-day run-in period. Patients intubated during the run-in period will not be included in the final analysis. Estimated enrollment in the final analysis is up to 9900 mechanically ventilated patients over 33 months. Study duration and enrollment targets may be adjusted prior to the intervention period based on C-SAT/SBT adherence and other data observed during the pre-intervention baseline period.