Generation of Ranked Lists and Clinical Workflow
CFPs from the baseline screening visit were input into the model. A list of deidentified participant IDs, ranked according to progression score output by the model (from highest to lowest) were provided to the Principal Investigator at each site.Patients were scheduled for their subsequent screening between September 2020 and January 2021 in the proposed order determined by the model from highest to lowest risk. Patients were provided with specific appointment dates by each participating hospital. However, in cases where a patient was unable to accept the given appointment, staff were instructed to find the nearest acceptable appointment day while ensuring that all participants will be screened within 12 to 14 months of their last DR screening, as per the standard of care. Because patients did not always show up on the appointed date, both the scheduled appointment and the actual screening dates were recorded to facilitate analysis. During the visit, clinical staff obtained CFPs and metadata according to routine screening protocol. Fundus images were obtained using Topcon Maestro 3D OCT-1, Topcon TRC NW300, Topcon TRC NW200 and Nidek AFC-210 cameras.