Ethics approval and consent to participate
MAY
The research was approved by the Clinical Research Ethics Committee of the First Affiliated Hospital of Anhui Medical University Institutional Review Board (IRB number: No. PJ2020-13-09), and written informed consent was obtained from each subject that attends the trial. In addition, the trial was registered before patient enrollment at the Chinese Clinical Trial Registry at 12/11/2020 (Clinical Trials Number: ChiCTR2000039864) and was conducted from November 2020 to May 2022 in accordance with the Helsinki Declaration.