Sensitivity and Subgroup Analysis
depression, psychiatric, anxiety
SENSITIVITY
Sensitivity analysis removing individuals randomized to bupropion did not materially change the estimates compared with the complete case Tobit model: β = −0.33 (95% CI, −0.53 to −0.12) for anxiety and β = −0.37 (95% CI, −0.53 to −0.21) for depression. Following multiple imputation, there was a difference in adjusted anxiety scores of β = −0.33 (95% CI, −0.53 to −0.12) for the Tobit model and β = −0.54 (95% CI, −0.70 to −0.37) for PSM and adjusted depression scores of −0.97 point (95% CI, −1.15 to −0.78 point) for the Tobit model and −0.53 point (95% CI, −0.67 to −0.40 point) for PSM.Among individuals without a psychiatric history who stopped smoking, the decreases in depression (−0.32 point; 95% CI, −0.48 to −0.15 point) and anxiety (−0.29 point; 95% CI, −0.50 to −0.08 point) scores were smaller than the decreases observed among individuals with a psychiatric history who stopped smoking (depression, −0.60 point; 95% CI, −0.82 to −0.38 point; anxiety, 0.48 point; 95% CI, −0.76 to −0.20 point).