Study outcomes and assessments
DISEASE, REMISSION, THIGH DISEASE, DISEASE
In this post hoc analysis, the proportions of patients achieving response at IP week 24 and at both IP weeks 40 and 52 (early sustained response) were assessed. The proportion of patients achieving the stringent endpoints of remission according to SDAI and Boolean criteria, and other endpoints, including Disease Activity Score in 28 joints using CRP (DAS28 [CRP]) < 2.6, during the IP were investigated by treatment arm.The flow of these patients in early sustained remission between SDAI categories (remission, LDA [> 3.3–11], moderate disease activity [> 11–26], and high disease activity [> 26]) during both the IP and DE period were plotted using Sankey diagrams. The Sankey diagram format was used to evaluate patterns of disease activity following de-escalation of abatacept in patients with sustained remission. As a comparison with patients with early sustained SDAI remission (IP weeks 24/40/52), Sankey diagrams were also plotted for patients with later sustained SDAI remission (IP weeks 40/52 but not 24).Heat maps were used to plot color-coded SDAI data across time points to visualize response trajectories for individual patients with early sustained (weeks 24/40/52) SDAI remission during both the IP and 48-week DE period.