Author contributions
PRS
S.K. and C.A.T. were involved in designing the study, conducted the analysis, prepared the manuscript draft, and are responsible for the overall results; C.R. performed the calculation of the PRS., J.P.P. conducted the UKB analysis, and K.B., C.R., A.S., and L.S. provided statistical consulting, performed calculations, and edited the manuscript draft. B.R. and R.S. were involved in critical review of the manuscript and editing the final manuscript; T.Z. was responsible for the handling of the biomaterial before transfer to the Broad Institute and provided critical review of the manuscript, A.Z. and K.W. were involved in the statistical analysis plan of the main trial and provided critical review on this work, L.F. provided consulting on the study design, the review of data and the manuscript draft, and P.T.E. and P.K. were involved in the study design, the review of data, the manuscript editing, and review. P.K. was also involved in the final manuscript, and the figure design and led the main trial as principal investigator.