RANO-LGG criteria (post hoc exploratory endpoints)
tumor, SD, PD, BOR, tumors
TUMOR, TUMORS
The ORR per RANO-LGG criteria was 53% (95% CI: 41–64), including 20 (26%; 95% CI: 17–38) patients with a PR and 20 (26%; 95% CI: 17–38) with an MR. Twenty-three (30%) patients had a BOR of SD, giving a CBR of 83%. ORR was similar in patients with tumors harboring Figure Similar to the RAPNO analysis, there was a subset of patients who initially had PD according to RANO-LGG criteria per IRC evaluation but who continued on treatment due to the absence of PD according to RANO-HGG criteria. Plots of tumor size (SPPD) over time in several of these patients showed a pattern of subsequent tumor shrinkage after the initial PD assessment (Extended Data Fig. 