Subject disposition and dosing
Of the 323 subjects screened, 282 were enrolled in the study, of whom 70 were rollover subjects and 212 were new subjects (including 24 enrolled as new subjects from the previous study because their last completed dose in the previous study was >45 days before the first dose in the current study; Subject disposition. DB, double-blind; DO, dose optimization; SDX-d-MPH, serdexmethylphenidate/dexmethylphenidate.On day 0, the mean (standard deviation [SD]) daily dose of d-MPH HCl equivalent was 32.54 mg (7.28 mg), or 0.94 mg/kg (0.35 mg/kg) of body weight. At 6 months of treatment, the mean daily dose of d-MPH HCl equivalent was 33.56 mg (7.11 mg), or 0.94 mg/kg (0.36 mg/kg). At the last dispensing visit, day 330, the mean daily dose of d-MPH HCl equivalent was 35.08 mg (6.38 mg), or 0.95 mg/kg (0.34 mg/kg) of body weight.