Landscape of gene mutation, tumour mutational burden, microsatellite instability, and drug sensitivity analysis
MSI, Tumour, Cancer
SENSITIVITY, TUMOUR, MICROSATELLITE INSTABILITY, CANCER
The mutation frequencies and oncoplot waterfall plots for both risk groups were analysed and visualized with the Tumour mutational burden (TMB) and microsatellite instability (MSI) could be regarded as an indicator to predict immunotherapy response. The presence of homologous recombination deficiencies, such as BRCA1/2 mutations, can lead to TMB amplification and contribute to immune checkpoint inhibitor sensitivity [Several common drug sensitivities were estimated from the Genomics of Drug Sensitivity in Cancer database (