Background
Gastric cancer, deaths, cancer
GASTRIC CANCER, RECURRENCE, CANCER, MALIGNANCIES, TUMOR PROGRESSION, CAVITY
Gastric cancer (GC) is one of the most common malignancies worldwide, ranking as the fourth leading cause of cancer-related deaths, and it has a poor 5-year survival rate, which is mainly caused by tumor progression and recurrence (Song et al. Hyperthermic intraperitoneal chemotherapy (HIPEC) provides direct delivery of concentrated, heated chemotherapeutic drugs into the abdominal cavity, maintaining the thermo-thermal effect and increasing the exposure of cancer cells to chemotherapy to improve the anti-tumor efficacy (Cai et al. This prospective, randomized, controlled study was performed to determine the clinical benefit of the combination of HIPEC and systemic chemotherapy on locally AGC patients after radical resection and provide an effective treatment strategy for these patients.