Statistics
Statistical analyses were performed using GraphPad Prism (GraphPad Software). Data sets were analyzed using non-parametric Wilcoxon matched-pairs signed rank test, Kruskal-Wallis, Friedman tests, or Fisher’s exact test. Dunn’s multiple comparisons test was used to correct for multiple comparisons where applicable. Handling of missing values due to missed visits (13 out of 1,150 visits) were determined before analysis according to the study protocol. In line with this, missing values were imputed in Figs using median values from the specific time-point in each cohort. All 