1. Introduction
arthroplasty, PJI, infections, periprosthetic joint infection
LYSING, INFECTIONS
Implant-associated infections are the most costly problem in modern orthopedics due to the continued increase in the occurrence of antibiotic-resistant bacterial strains that requires the development of new effective antimicrobials. A non-randomized, prospective, open-label, with historical control study on the use of combined phage/antibiotic therapy of periprosthetic joint infection (PJI) was carried out. Forty-five adult patients with deep PJI of the hip joint were involved in the study, with a 12-month follow-up after one-stage revision surgery. Patients from a prospective study group (SG, Implant-associated infections are the most costly problem in modern orthopedics, with socially significant losses being their most pronounced aspect. Diagnosis and identification of the pathogen, as well as the choice of a rational surgical approach and effective antibacterial therapy, are the key points that determine the outcome of treatment of periprosthetic joint infection (PJI).Currently, an increase in the occurrence of antibiotic-resistant strains, such as methicillin-resistant It has been previously shown that if acute PJI caused by antibiotic-resistant strains is treated without implant removal, the rate of successful outcomes is low, approximately 18% [One of the promising alternatives is the use of bacteriophages, that are natural viruses capable of infecting and lysing bacteria [Previously, a non-randomized pilot study on the use of combined phage/antibiotic treatment of PJI in patients after hip joint arthroplasty has been carried out in Novosibirsk Research Institute of Traumatology and Orthopedics, Russia [