Treatment
Dukes’ B3 and C disease
Perioperative chemotherapy consisted of 5-FU administered as a continuous infusion, 600 mg/mAdjuvant chemotherapy for patients with Dukes’ B3 and C disease consisted of either levamisole and 5-FU or leucovorin and 5-FU. From August 1993 to August 1997, levamisole and bolus 5-FU for a total of 12 months was the prescribed therapy. The dose/schedule was levamisole: 50 mg PO TID days 1–3 and 15–17; then 50 mg PO TID × 3 days beginning day 29, repeated every 14 days for 11 months and 5-FU: 450 mg/mDose modifications for adjuvant levamisole and 5-FU were as follows: (1) absolute granulocyte count (AGC) on the day of treatment ≥ 1000 and < 1500/mmDose modifications for adjuvant leucovorin and 5-FU were as follows: (1) for a nadir WBC 1000–2500/mm