Statistical methods
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Statistical evaluation were performed with SPSS® Statistics Version 27 (IBM Corporation Armonk, New-York, USA). Graphs were created using Prism 9® (GraphPad Software Inc., Boston, USA). Descriptive representation of nominal variables is presented with numbers (n) and valid percentages (%). Normal distribution was determined using Shapiro–Wilk test. Cluster comparison was presented using the chi-square test. If the expected frequency of data was below 5, Fisher's exact test was applied. Quantitative data were reported with mean value, standard deviation and were compared using the Mann–Whitney U test. The 