Study design
glioblastoma
GLIOBLASTOMA
The study was initially designed as a prospective randomized pilot study, with randomization between biopsy and LITT in the same session (n = 10) and biopsy alone (n = 10). The main goal of randomization in the pilot study was to determine whether patients with glioblastoma were willing to be randomized for biopsy and LITT versus biopsy only. After including the first 11 patients and treating the first 9 patients, randomization was stopped as the feasibility endpoint with respect to willingness to be randomized was met. From then onwards patients were only included in the LITT arm until the target number of 10 patients in the LITT arm was reached.This study is reported in accordance with the extension of the Consolidated Standards of Reporting Trials (CONSORT) for randomized pilot and feasibility trials [