3. Discussion
obesity, cancer
OBESITY, INFILTRATION, CANCER, CLEAR CELL RENAL CELL CARCINOMA, DISEASES, INFLAMMATORY DISORDER, METASTASES
A nephrectomy remains the most efficacious option for primary clear cell renal cell carcinoma (ccRCC), despite the fact that 20–40% of patients experience relapses and metastases following the surgery [Chemerin (RARRES2), an adipokine and chemoattractant factor, has been implicated in obesity, inflammatory disorders, and cancer [The analysis of immune cell infiltration is of paramount importance in the assessment and management of diseases. This study involved a thorough examination of the immune landscape in patients in varying ccRCC risk groups. To explore the abundance and functions of immune cells, we utilized the CIBERSORT, ESTIMATE, and ssGSEA methodologies. Notably, the levels of immune cell infiltration, particularly CD8In this study, however, experimental studies were not conducted to validate the functions of the seven genes. Consequently, additional clinical trials will be required to substantiate the predictive capability of the risk model.