Limitations
malaria
MALARIA, RECRUITMENT
Forest workers in this study were those who were residents of the villages where the recruitment was conducted. It was not known how many migrant workers from other provinces worked periodically in forested areas of the trial province and, therefore, they could not be recruited. The field reports contained the research team`s notes, questions and topics that had been discussed with participants. Data were not collected on reasons for forest goers to participate. Although the proportion of community participants completing the trial procedures was used as a measure of the effectiveness of engagement, the participation can be influenced by several other factors including tolerance of the drug-regimen, peer pressure and economic pressure (5 USD compensation was provided for lost income). MORU’s various studies and activities such as clinical trials, epidemiological studies and engagement activities have been conducted since 2018 which may have demonstrated the continuous presence, built community relationship and the trust ultimately affecting the participation in the current trial.There is also a need for malaria chemoprophylaxis that can be taken by women of reproductive age. Moreover, it is important that this vulnerable population should not be excluded from research, therefore, a strategy was designed for their participation in the trial. Due to the limited duration of chemoprophylaxis (3 months) a strategy was evaluated that this population can access without sacrificing childbearing.Assessing full comprehensibility of the trial procedures and of the informed consent (study procedures, benefits and harms of study drugs) was beyond the scope of this study. Nonetheless, participants` understanding of the trial was assessed by quantifying successful participation, and by evaluating observational meeting notes, which indicated a fair amount of comprehension. These claims are based on our efforts and focused on simplifying the study contents, and promoting independent decision-making by participants.