Study population (
high-grade glioma, midline glioma
Participants must be ≥ 18 and ≤ 39 years old at the time of enrollmentParticipants must have recurrent high-grade glioma or midline glioma based on clinical and/or radiologic findingsPatients will be recruited to the NIH Clinical Center in Bethesda, MD.Target of 5 completed patients.Withdrawals which do not complete the initial study procedures will be replaced up to the accrual ceiling of 7 patients