Patient selection and allocation
Bleeding, PD, allergy, obstructive pulmonary disease
ALLERGY, OBSTRUCTIVE PULMONARY DISEASE, CAVITY, BLEEDING, PATHOLOGY, HIV PERIODONTITIS
The study included systemically healthy adult participants (18–75 years, inclusive) affected by stage III–IV periodontitis. The participants were selected from the general population afferent to the aforementioned centers. The inclusion criteria for the study population were as follows:Diagnosis of stages III–IV periodontitis[At least 15 sites with probing depth (PD) 5–9 mm and positive to Bleeding on Probing (BoP)The exclusion criteria for the study population were as follows:Pregnant or lactatingCurrent or past (within 3 months of enrolment) medications that may influence periodontal conditions and/or interfere with healing following periodontal treatment (i.e., corticosteroids, calcium channel blockers)Non-surgical and/or surgical periodontal debridement within 3 months of enrolment, the use of systemically administered antibiotics within 3 months of enrolmentTumors or significant pathology of the soft or hard tissues of the oral cavity, or current radiotherapy or chemotherapyChronic obstructive pulmonary disease and asthmaHistory of allergy to erythritol or chlorhexidinePresence of orthodontic appliancesSmokers were included in the study.All participants signed written informed consent before the beginning of the study. Randomized patient allocation to either test or control intervention was performed centrally using ad hoc software (R version 3.6.1, R Core Team (2020). R: A language and envi- ronment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. URL 