Group I (urea 40% pretreatment)
HYPERKERATOSIS
40% urea ointment was employed to soften the plates of the affected nails and vaseline was applied in periungual skin to prevent irritating effects of urea at high concentrations. Once the urea and vaseline were applied, the nail was covered by an occlusive dressing for 12 h at night. Urea softening treatment was limited to 4–5 days in toenails with hyperkeratosis < 2 mm and 7 days in those with hyperkeratosis ≥ 2 mm [