Results
LEIOMYOMAS
Of the 69 patients enrolled in the study, 47 women completed the questionnaires either in person, by telephone, by mail or online. Twenty-four patients were from the medical intervention arm, and 23 patients had surgical intervention using the TruClear™ hysteroscopic tissue removal system. Of the 69 patients who completed their questionnaire, 42 completed by month 1, 36 completed by month 3, and 49 completed by month 6. However, two patients who completed the questionnaire at 6 months or greater interval did not meet the requirements of the study at the submission of the questionnaire. One patient had her IUD removed and another patient had an endometrial ablation performed prior to her questionnaire submission. Therefore, these two patients’ questionnaires were deemed invalid after their submission.Patient demographics collected include age, body mass index (BMI), race, parity, history of medical problems and surgery(s) are shown in Table 
Demographics of Study ParticipantsA total of 22 patients dropped out of the study. The same number of patients (N = 11) dropped out from the surgical arm, like the number of patients who dropped out of the medication treatment arm (N = 11). The most common reasons for dropping out in either arm included lack of patient response, patient changing her mind after study enrollment, and request or requirement of (additional) surgery (Fig. 
Subject Disposition FlowchartAll patients in the surgical arm were treated under general anesthesia for hysteroscopic myomectomy in the outpatient setting. Although the surgical times were not measured, a vast majority of the surgeries were completed within an hour. Meanwhile, the patients in the medical arm did not undergo hysteroscopic assessment but only pelvic ultrasound measurement of their submucosal leiomyomas.Between the two treatment groups, UFS-QOL scores were similar at baseline (Table 
UFS-QOL Scores at Baseline (Month 0)
Comparison of Changes in UFS-QOL Scores from BaselineHigher improvement scores were noted in the surgical group compared to the medical group for all UFS-QOL scores except for HR-QOL concern score at 1 month, HR-QOL self-conscious score at 1 month, HR-QOL sexual function score at 1 month and 3 months, and HR-QOL total score at 1 month. At ≥ 6 months, the most considerable score improvements for the surgical group were reported in HR-QOL concern, activities, self-conscious and symptom severity scores having mean change scores (95% CIs) of 35.3 (22.3–48.2), 28.9 (16.3–41.5), 28.6 (15.0–42.1), and 32.2 (21.5–43.0), respectively.