Impact of Coronavirus Disease (COVID-19)
coronavirus disease, pleural infection
PLEURAL INFECTION, RECRUITMENT
The coronavirus disease (COVID-19) pandemic presented significant challenges. The first wave in the United Kingdom began in March 2020, 4 months after trial recruitment began (November 2019). The main impact was to trial recruitment rates, which, having been ahead of target, decreased substantially (Figure E1 in the online supplement). Based on a separate analysis of screening data, pleural infection rates in the United Kingdom decreased by approximately one third during the pandemic (