3. Discussion
HYPERTENSION
In this research, for the first time, steady-state CBD concentrations in plasma and urine samples were monitored over a 12-week period (84 days) with volunteers with hypertension. No statistical difference was observed in the CBD and CBD metabolites concentrations of participants who consumed and participants who did not consume angiotensin-converting enzyme (ACE) inhibitors, calcium blockers, and thiazide diuretics.We found that the amount of CBD in the second 2.5 weeks of intake (5 weeks after the beginning of CBD consumption) increased by 50% compared to the first dose. CBD is mainly metabolized to 7-carboxy metabolites, as already confirmed by previous studies [In contrast to our study, Perez-Acevedo et al.’s findings demonstrated that the concentration of 7-OH-metabolites in urine was higher than 7-COOH metabolites [In their study, which lasted 7 days, Taylor et al. administered doses of 1500, 3000, 4500, and 6000 mg per day [