2.4. Randomization and Allocation
After enrollment based on the eligibility criteria, the central randomization method was applied based on computer software. The enrollment and randomization process were conducted by a third party that was unrelated to the clinical examination. The participants were arranged into control or test groups in a ratio of 1:1, with 45 participants in each group. Investigators were blinded to randomization and allocation concealment until the completion of the studies.