2.7. 6-MSITC and Placebo Supplements
The 6-MSITC group took one 6-MSITC capsule that contained 100 mg wasabi extract powder containing 6-MSITC (0.8 mg) absorbed on α cyclodextrin and a 100 mg vehicle (calcium stearate, starch, and silicon dioxide) per day. The placebo group took one placebo capsule containing α 100 mg cyclodextrin and the vehicle per day. The main compositions in each capsule are summarized in We set the dose of 6-MSITC (0.8 mg) based on previous findings using 6-MSITC. There were two reasons. First, the dose of 6-MSITC differed among previous studies (from 0.8 to 9.6 mg). Previous studies with 4.8 mg or 9.6 mg of 6-MSITC were conducted using a pre–post intervention design without control groups [