3.5.2. NCL—explorative statistical tests
NCL, caries
REGRESSION, SECONDARY, CARIES
The secondary efficacy endpoint for NCL is the proportion of subjects showing no increase in NCL% (ΔNCL = NCL% ΔNCL%With ΔNCL%ΔNCL%Percentage of subjects without increase of NCL% (percentage of caries lesions) in the PP set.The upper limit of the one-sided 95% confidence interval for the difference in proportion of subjects without an increase of NCL (ΔNCL%In addition, a logistic regression analysis was performed for the secondary endpoint NCL (increase in NCL vs. no increase in NCL) as dependent variable and toothpaste, center, sex, and age as independent variables (covariates). The results for the PP population confirmed that the “risk” of increase in NCL did not differ significantly between control and test toothpaste. Furthermore, the risk did not differ significantly between centers and was not dependent on age and sex.