Conclusions
disuse-induced muscle atrophy
We showed that FOR ingestion was safe and tolerable, and it prevented the rise in myostatin observed after the 6-wk protocol, which included 2 weeks of single-leg immobilization. However, the unchanged myostatin circulation concentration in the FOR group did not affect the molecular markers related to myostatin-regulated signaling in skeletal muscle and did not attenuate disuse-induced muscle atrophy. We note that 2 weeks of normal activity following two weeks of immobilization was insufficient to recover the decline in muscle CSA and peak torque during disuse.