Methods for additional analyses (e.g. subgroup analyses) {20b}
death, TTP
REGRESSION, TTP
Descriptive summary statistics, such a mean/median of the time to culture conversion will be tabulated. Proportion of participants achieving culture conversion at each time point during treatment will be summarized.A Cox regression model will be used to compare each arm with different DZD doses to the background regimen without DZD, censoring for death and loss to follow-up, to estimate the hazard ratio. The analysis will be adjusted for the baseline cultures using time to positivity (TTP) at the time of screening and enrolment. Demographic and clinical characteristics, such as gender, age, race, BMI, HIV status, smoking, and alcohol usage, will also be adjusted in sensitivity analyses.