Apremilast reduces dependence-induced escalations in alcohol intake in C57BL/6J mice.
alcohol dependence
To test whether apremilast reduces harmful drinking associated with alcohol dependence, 2 models of dependence-induced escalations in ethanol drinking were used in C57BL/6J mice, an established high-drinking strain from which both methods were developed (Because dependence in individuals with AUD is characterized by chronic harmful drinking, we next sought to test the effects of apremilast in a chronic model of dependence-induced escalations in alcohol drinking (