Introduction
disturbance of systolic and diastolic function, atherosclerotic, CAD, ST-elevation myocardial infarction, necrosis, heart failure
MYOCARDIAL INFARCTION (MI), CARDIOVASCULAR DISEASES, DISEASE, PLAQUE, CORONARY ARTERY DISEASE, NECROSIS, HEART FAILURE, CAD, VENTRICULAR HYPERTROPHY
Coronary artery disease (CAD) is a disease caused by an inadequate supply of blood and oxygen to the myocardium. This condition made the oxygen demand higher than the oxygen supply to the myocardium, which occurred from the complete or partial occlusion of the coronary arteries lumen due to atherosclerotic plaque [When there is complete occlusion which makes myocardial cells necrosis, it will become myocardial infarction (MI) and might show the ST-elevation myocardial infarction (STEMI) pattern in ECG [MI could develop into cardiac remodeling through the cellular, molecular, and proteomic process which causes ventricular hypertrophy. This condition promotes myocardial wall change, contractility impairment, and disturbance of systolic and diastolic function, so it could lead to heart failure [In order to prevent heart failure due to cardiac remodeling, it is important to regulate markers that are elevated in MI conditions that could lead to cardiac remodeling. Along with the development of research, colchicine is widely used in the treatment of cardiovascular diseases. Colchicine is a potent agent which could exhibit some anti-inflammatory actions by inhibiting neutrophil chemotaxis, inflammasome network, and pro-inflammatory cytokines [