Study Design
WEST
SECRAB was a large randomised, phase III trial comparing sequential chemotherapy followed by radiotherapy with synchronous radiotherapy given concurrently or as a sandwich with chemotherapy [The protocol and subsequent amendments were approved by the West Midlands Multi-centre Research Ethics Committee and by the research and development department at each centre. The trial was carried out in accordance with The Code of Ethics of the World Medical Association (Declaration of Helsinki). All patients provided informed consent.