Study population
tumor, hepatic dysfunction, blood coagulation, tooth, ankylosis, hypersensitivity, allergic reactions, diabetes
TUMOR, ALLERGIC REACTION, THROMBOCYTOPENIA, HEMATOLOGIC DISEASES, MAY, ANKYLOSIS, HYPERCEMENTOSIS, HYPERSENSITIVITY, DIABETES
A cohort of patients of the Department of Oral and Maxillofacial Surgery of University Medical Center Mainz, Germany, were included in the study from May 2022 to December 2022. General inclusion criteria were people of any age or gender under monotherapy of FXa inhibitor without other additional antithrombotic or anticoagulant medication, with normal blood coagulation parameters and that required extraction of two teeth each on contralateral sides of the same jaw. Exclusion criteria were patients with hepatic dysfunction; hematologic diseases; thrombocytopenia; immune-, radio-, or chemotherapy; bisphosphonate and antiresorptive therapy; pregnant or nursing patients; uncompensated diabetes; patients with hypersensitivity or allergic reactions to the local anesthetic; disabled patients; a tooth involved in an acute inflammatory process; cyst or tumor; extraction tooth sides needing osteotomy (ankylosis or hypercementosis); need for subperiosteal preparation; contact of the extraction socket with the mandibular nerve canal; connection to the maxillary sinus after extraction.All patients were informed and signed a consent form for inclusion in the study. All patients underwent presurgical orthopantomography and a postoperative clinical control immediately after the surgery, after 30 min, after 1 h, 1.5 h, and at follow-up appointments at 24 h, and on the 7th day after the tooth extraction.