Findings
tumors
TUMORS, STS
In this phase 1 nonrandomized controlled trial of 12 patients with advanced STS, intratumoral GLA-SE with radiotherapy was well tolerated, with all patients achieving local control of injected tumors. Durable local response was associated with expansion of intratumoral T-cell receptor clones, and these specific clones were detectable in the systemic circulation following intratumoral GLA-SE.