Results
abdominal spasms, lower anterior resection syndrome, pain
INCONTINENCE, ADVERSE EVENTS, SECONDARY, SYNDROME, EVENTS
Some 64 patients with severe LARS were considered eligible. Of these, 32 (22 men) met the inclusion criteria and were randomized. One patient in each group was excluded (1 performed TAI in SOC group and was excluded; 1 deferred performing the enemas in TAI group and was no longer eligible) (Study flow chart and changes in lower anterior resection syndrome score from baselineBy 3 months, the mean LARS score in the overall population had decreased from 38.3 to 26.5 (Results for primary and secondary endpoints: comparison between groupsTAI, transanal irrigation; SOC, standard of care; LARS, lower anterior resection syndrome; FIQL, Faecal Incontinence Quality of Life; EQ-5D-5L™, EuroQol Five Dimensions 5L (EuroQol Group, Rotterdam, the Netherlands); VAS, visual analogue scale. *Unpaired A total of 17 adverse events occurred in 14 patients (none severe). Seven events in five patients were related to irrigation pain at the anus (2), and abdominal spasms and transit disturbance during irrigation (5). The mean(s.d.) volume of water used per irrigation per day was 718(135) ml. The time spent on bowel management per day decreased significantly in TAI group as compared to SOC group (