Body weight
HED
Body weight decreased by 0%, 7%, 10% and 12% from baseline in CON, DCON, MED and HED, respectively, and decreased more in all intervention groups than in CON (Tables Within-group changes (0–16 weeks) in cardiometabolic outcomesData are estimated means with 95% confidence intervals. Data were analyzed using a constrained baseline longitudinal model (two-sided). No corrections for multiple comparisons were performed. Reduction is defined as at least one step down on the predefined algorithm. Discontinuation is defined as discontinuation of all drugs when therapeutic target was met. Intensification is defined as at least one step up on the predefined algorithm. Pairwise comparisons of the change in cardiometabolic outcomesData are estimated means with 95% confidence intervals unless stated otherwise. Reduction, Discontinuation and Intensification are defined as in Table 