Recruitment {15}
The 24-month inclusion period allows a reasonable mean rate of randomized patients of 1.39 patient/month/center. All participating centers are large and well-experienced liver transplantation centers in France. To ensure an adequate number of patients will be enrolled in the required time frame, the participating centers will be asked to report on a regular basis their problems related to enrolment, in order to find adequate responses to improve the enrolment rate. Moreover, to stimulate enrolment, a newsletter describing the enrolment status will be sent regularly to all centers.