CONCLUSIONS
inflammation, CAD, T2D
INFLAMMATION, CARDIAC EVENTS, CAD
Although our conclusions are limited due to low statistical power in some groups and high inter‐individual variability, these data regarding plasma concentrations of cytokines in patients with CAD and T2D remain of high value for comparison and/or compilation in future studies/meta‐analyses. While we did not find an increased effect of the HIIT‐based exercise intervention program on reducing the cytokines in the circulation of the study participants compared to the MICT‐based intervention, both training types reduced inflammation in these patients. This effect was preserved in patients with both CAD and T2D, and even more pronounced for FGF21 and IL‐6, suggesting that T2D does not interfere with the positive effects of exercise on inflammatory markers. Our findings highlight the potential for both HIIT and MICT to help patients with CAD and co‐morbidities such as T2D to reduce their risk factor of adverse cardiac events by regulating the levels of certain inflammation‐related markers such as the cytokines discussed (i.e., FGF21, IL‐6, IL‐8, IL‐10, and IL‐18).