Sample size and power calculation
Diabetes
DIABETES
Determination of non-inferiority margin was carefully considered, following extensive consultation. A questionnaire was sent to all investigators, British Society for Paediatric Endocrinology and Diabetes clinical study group members, and a patient support group representative (Whilst the percentage of children reaching mid-parental TH [For the primary outcome measure of near FH-SDS with a non-inferiority design comparing means and assuming equal variance, a non-inferiority margin of 0.55 near FH-SDS, a one-sided test with alpha = 0.025 and 90% power, a group size of 57 (total 