1. Introduction
tissue damage
OXIDATIVE STRESS, GENOTOXICITY, ENZYME INHIBITION
Adequate antioxidant supply is essential for maintaining metabolic homeostasis and reducing oxidative stress during detoxification. The emerging evidence suggests that certain classes of phytonutrients can help support the detoxification process by stimulating the liver to produce detoxification enzymes or acting as antioxidants that neutralize the harmful effects of free radicals. This study was designed to examine the effects of a guided 28-day metabolic detoxification program in healthy adults. The participants were randomly assigned to consume a whole food, multi-ingredient supplement (The environment contains close to 80,000 novel chemicals, which are registered with the United States Environmental Protection Agency (EPA), but many have not had thorough reviews for their risk to human health [Direct exposure, as well as the bioaccumulation of toxic chemicals in human tissues, make them a major continuous threat to human health. More so, the mechanisms by which environmental pollutants cause disruptive health effects may include tissue damage, endocrine signaling, genotoxicity, enzyme inhibition, oxidative stress, and changes in the activity of the gene expression networks that modulate them [The human body largely relies on the liver to metabolize and direct exogenous chemicals to tissue storage or excretion [Additionally, the liver detoxification system is supported by endogenous antioxidants (GSH, reduced glutathione), dietary antioxidants (ascorbate), and antioxidant enzymes, such as superoxide dismutase (SOD), catalase, glutathione reductases, glutathione peroxidases (GPXs), and glutathione S-transferases (GSTs), that enable scavenging of reactive oxygen species (ROS) and free radicals arising from healthy cellular metabolism, as well as the detoxification of xenobiotics [Nutritional status and dietary intake patterns can have a profound effect on the body’s ability to absorb, conjugate, and excrete potentially dangerous toxins [