Patients
This prospective, single-centre, randomised controlled trial was performed at Severance Hospital, Yonsei University Health System, Seoul, South Korea. This study was approved by the institutional review board of Severance Hospital, Yonsei University Health System (50 − 1 Yonsei-ro, Seodaemun-gu, Seoul, Korea; # 4-2019-1336) and written informed consent was obtained from all individuals participating in the trial. The trial was registered prior to patient enrolment at clinicaltrials.gov (NCT04291339, Principal investigator: Hyun Joo Kim, Date of registration: 02/03/2020). The study protocol followed applicable SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) guidelines. This study was conducted in accordance with the Declaration of Helsinki and the relevant guidelines.