Statistical analysis
All animal groups were age and weight-matched male and randomized to study groups. We use Stata 17 (Stata Corp LP, College Station, TX) for statistical analyses. The Kolmogorov-Smirnov test was used to evaluate the normality of distribution. For normal distributions, continuous variables were compared for two groups using unpaired t-test and ≥3 groups using ANOVA. Non-parametric tests were used for data not normally distributed. Kaplan Meier analysis was used to compare survival over time between groups. Bonferroni’s correction was applied when a sample had multiple time points/treatment measurements. A p-value of 0.05 was considered significant and is denoted with an asterisk (*) in the figures.