References
toxicity
HIVES
CONSORT flowchart. PLA, placebo; PRO, propolis; ITT, intention-to-treat; PP, per-protocol. Obtained from honeybee hives and extracted using ethanol. Wheat germ oil is extracted by pressing the wheat germ and is used as a solvent for propolis supplements. Therefore, it was selected as a placebo in this study. The supplements used in the present study are commercially available as health foods. As for the dosage of propolis, an animal toxicity study has shown that the non-observed effect level is 1400 mg/kg/day [Absolute fat mass (Boxplots showing values of serum levels of adiponectin (Baseline characteristics of the participants in each group.Data are presented as mean ± standard error of the mean or median (interquartile range). Significant differences were analyzed using the Student’s unpaired Measurements before and after 12 weeks of supplementation with propolis and placebo Data are presented as mean ± standard error of the mean. Results from both ITT and PP analysis are shown. Variables were analyzed via two-factor repeated-measures analysis of variance, with time (week 0 vs. 12) and group (placebo vs. propolis) as factors. A 