Characteristics of responders and non-responders
Similarities and differences at trial baseline between characteristics, outcome scores and utility values of participants who provided four year follow-up data and those who did not are provided in additional file Figures depicting the difference in means over time for the responders vs. non-responders for the two primary outcomes by arm suggest that the data is not missing at random (Figs. 
Mean BPI severity over time by trial arm and response to the four-year follow-up
Mean BPI interference over time by trial arm and response to the four-year follow-up
Cost effectiveness acceptability curve showing the probability that the STAR care pathway is cost-effective at different willingness-to-pay thresholdsDifferences between the responders vs. non-responders to the four year follow-up were also seen in the EQ-5D-5 L. Baseline utility values were similar in patients who received usual care at 12 months. However, in the intervention group, patients who completed the EQ-5D-5 L questionnaire at a median of four years after randomisation had higher (baseline) utility values than those who did not complete this measure.