Safety
headaches, headache
ADVERSE EVENTS
All study products were tolerated well, and no serious adverse events were reported. Sixty-seven adverse events were reported in 24 (60%) participants, with mild headache being the most common. Two headaches were judged to be related to use of Vuse Vibe, three related to nicotine gum use, and one related to smoking UB. All other adverse events were reported in three or fewer participants. Twenty-four AEs were judged to be likely related or related to investigational product use, with four related to Vuse Vibe, two related to Vuse Ciro, three related to UB cigarette, and fifteen related to nicotine gum (details provided in Supplementary Table 