PK analysis
SAD
The PK parameters were calculated with WinNonlin 7.0 (Certara, Princeton, NJ, USA) using noncompartmental analysis. As the PK parameters of the SAD study were previously reported, calculations of PK parameters for the MAD study and the food effect study were conducted in this report. In the MAD study, PK parameters of forsythin and its main metabolites M2 and M7, including 