Food Effect Assessment
In the single-agent dose-escalation stage, giredestrant was taken under fasted conditions (fasted for ≥6 hours overnight) until cycle 4 day 1. To explore whether giredestrant had a potential food effect, patients in the single-agent dose-expansion cohorts were able to take giredestrant with or without food, and were asked to complete a food diary at cycle 2 day 1. Patients who had reported fasting for longer than 6 hours before giredestrant dosing were considered as fasted.