Effects of azithromycin on airway microbial interactions within the microbial community network.
To explore the changes of microbial interaction after exposure to azithromycin, a bacterial community network analysis was performed. The azithromycin group networks became less complicated and stabilized after the antibiotic exposure regarding decreases in the total number of vertices, edges, connectance, average degree, average clustering coefficient, and centralization closeness (Fig. S7). The co-occurrence patterns of microbial communities before and after azithromycin administration were quite distinct (The network analysis in the azithromycin group. (A) Networks of co-occurring ZOTUs in airway microbiota for time points D0, D4, D14, D30, and D60. Nodes are colored by ZOTU genera, with size proportional to mean relative abundance and edge width proportional to confidence score. (B) The number of shared edges between network D0 and time points D4, D14, D30, and D60. (C) The closeness centralization of shared nodes between network D0 and time points D4, D14, D30, and D60.