Background
pseudomembranous, inflammation, pain, RAU, ulcer
INFLAMMATION, RECURRENT APHTHOUS ULCER, ULCER, ADVERSE EFFECT
Recurrent aphthous ulcer (RAU) is the most common painful oral lesion and affects patients’ quality of life (QoL) [RAU presents as an ovoid or round well-defined ulcer, with a pseudomembranous yellowish gray center, and an erythematous circumscribed border [Currently, there are no curative therapies for RAU. Thus, RAU management primarily focuses on pain relief, reducing inflammation, and promoting wound healing. Topical steroids are an acceptable first-line pharmacological intervention for RAU [In recent years, there is considerable public interest in the use of cannabis for medical purposes. Cannabinoids are one of the major medicinal components of cannabis. They are synthesized in the human body and produced by the cannabis plant. The two active medical components from the cannabis plant are ΔMedicinal cannabis products are defined as dried female flowers of The safety of CBD has been demonstrated in animal and human studies. It has a low adverse effect profile, including when chronically used [CBD might be an alternative approach for RAU management due to its known clinical benefits, particularly in reducing pain and inflammation and promoting wound healing [