Ethics approval and consent to participate
The PACINPAT trial was approved by the “Ethikkommission Nordwest- und Zentralschweiz” (EKNZ, project number 2018–00976). The PACINPAT trial has also been registered in the ISRCTN registry (ISRCTN10469580). Before participation in the trial participants were informed about the goals, their right to withdraw from the study at any time without negative consequences and signed an informed consent form.