Population
impaired renal or hepatic function, diabetes, T2DM, unawareness
RECURRENT SEVERE HYPOGLYCAEMIA, COMPLICATIONS, DIABETES
Subjects who were 18–75 years old and with previously untreated T2DM (no oral or injected anti-diabetes treatment before 8 weeks of randomisation) were eligible for screening. After a 4-week diet and exercise run-in period, eligible study participants with poor glycemic control (hemoglobin A1c [HbA1c] values of 7.5% to 10.5% inclusive and fasting blood glucose [FBG] ≤ 13.9 mmol/L) were included in the trail. Main exclusion criteria were: treatment with any antihyperglycaemic medication within the run-in period of the trial; hypoglycaemic unawareness or recurrent severe hypoglycaemia; anaphylactic reaction or contraindication to any IMP or placebo; impaired renal or hepatic function; acute or severe chronic complications of diabetes. The full inclusion and exclusion criteria are avaliable in Supplementary table 