Patient data
abortions, infertility, endometrial polyp, endometrial growth insufficiency
DILATION, CAVITY, ENDOMETRIAL POLYP, ECTOPIC PREGNANCIES
The age of the patients did not differ significantly between the groups and averaged 34.9 ± 4.0 years. The body mass index was 22.4 ± 3.4 kg/mMost of the patients had a history of repeated intrauterine interventions, including hysteroscopies with dilation and curettage (D&C) of uterine cavity and cervical canal, endometrial polyp resections and diagnostic laparoscopies. The incidence of births, ectopic pregnancies and abortions was similar. There were no losses and exclusions in any group after randomization. The data for Groups 1–3 is given in Table Clinical history indicators for Groups 1–3.*the data are presented as mean ± SD, subject to ANOVA.**the data are presented as raw counts and % incidence, subject to exact Fisher test.Significant values are in bold.It should be noted that, despite the lack of formal statistical assessment, Group 4 had clinical history loads comparable with the rest of the cohort. IVF implantation failures and ET cancellations were encountered by 4 patients out of 5, and 4 patients out of 5 underwent diagnostic hysteroscopies. All patients in this group (n = 5) had at least one D&C procedure in anamnesis.Prior to the enrollment, the vast majority of the cohort had had a history of IVF implantation failure and/or cryotransfer cycle cancellation due to endometrial growth insufficiency. The infertility duration was comparable in all groups and averaged 4.7 ± 3.2 years. All patients had previously received estrogen therapy for thin endometrium, administered orally or transdermally in high doses, as well as repeated courses of physiotherapy. It is important to note that, in addition to hormonal therapy, the patients had also received auxiliary ('add-on') interventions, including non-invasive intrauterine infusions (instillations) of G-CSF and autologous PRP (0.5–1 mL).