Secondary analyses: Gene expression analyses, body composition, depression, sleep, and stress ratings
depression
SECONDARY, APPENDIX
There were no statistically significant differences between groups for stress, sleep, or depression. There was a significant decrease in mean PHQ‐9 (depression) and PSQI (sleep) (There was a significant decrease in BFM, BMI, and visceral fat area (The group × time interaction gene expression analysis identified 98 genes that were differentially expressed using routinely accepted fold change cutoff values (86 upregulated genes >1.5‐fold change, and 12 downregulated genes <0.5‐fold change in the exercise group compared with control group). This number is insufficient for secondary enrichment analyses. Using more liberal fold change values of >1.2 and <0.8 for this exploratory analysis, 2653 DEGs were identified (1075 upregulated genes >1.2‐fold change, and 1778 downregulated genes <0.8‐fold change) (Appendix Pathway analysis was performed using Advaita Bio's iPathwayGuide, which scores pathways using the Impact Analysis method (Draghici et al., 