References
Pain, ±, cancer, malignancy, dementia, pain, allergies, diabetes
ADVERSE EVENTS, CANCER, INFECTIOUS DISEASE, ALLERGIES, OXIDATIVE STRESS, DIABETES
Flowchart of the study.Average numeric pain rating scale scores (NPRS-11) reported at baseline, mid-study (6 weeks) and at the end of the study (12 weeks). Results are expressed as means plus standard deviations. Data were analyzed using two-way ANOVA corrected for multiple comparisons with a Tukey test (* Average numeric brief pain interference scores (BIP) related to physical activity and function at the baseline, mid-study (6 weeks) and end of the study (12 weeks). Results are expressed as means ± SD. Data were analyzed using two-way ANOVA corrected for multiple comparisons with a Tukey test (** Average numeric brief pain interference scores (BIP) related to sleep and emotional wellbeing at the baseline, mid-study (6 weeks) and end of the study (12 weeks). Results are expressed as means ± SD. Data were analyzed using two-way ANOVA corrected for multiple comparisons with a Tukey test (** Changes in the oxidative stress biomarker in the peripheral blood mononuclear cells, measured using CellROX Orange reagent. Results are expressed as means ± SD. Data were analyzed using the paired-samples Inclusion and exclusion criteria of the study.Male and female individuals aged 25–75 years oldSelf-reported pain due to a combination of two types of pain related to bone/muscle-related pain and back pain, joint pain and back pain, or cervical pain and joint painPain duration of 3 years or moreSubjects are not using narcotics to manage pain (anti-hypertensive and lipid-lowering medication allowed)Subjects are not using “warfarin” or any other blood-thinning medicationSubjects do not have suspected dementia or other neurological disordersSubjects do not have a pacemaker or any severe medical condition (e.g., insulin-controlled diabetes), or any medical condition that includes serious treatable causes of pain (i.e., cancer, etc.)Subjects must not be pregnant or nursingSubjects must not be a tobacco userSubjects must not have any allergies to fish, hempSubjects who are experiencing any adverse events due to any nutraceutical, OTC, pharmaceutical, or investigational productsSubjects who self-report a clinically significant condition (e.g., pregnancy, chronic condition, infectious disease, or malignancy, etc.) that, in the opinion of the investigator, would compromise the study or their well-being, or would prevent the participant from meeting or performing study requirements.Subjects that do not comply with the study protocol (i.e., missing study appointments, etc.)Subjects who enroll concomitantly in a different clinical study that, in the opinion of the investigator, would compromise the study or their well-being, or would prevent the participant from meeting or performing study requirementsDemographic, anthropometric, and baseline data of the study participants (means and standard deviations [±]).Abbreviations: NPRS-11—11-Point Numeric Pain Rating Scale; BPI—Brief Pain Inventory.Means and standard deviations of the Brief Pain Inventory by group.Abbreviations: BPI—Brief Pain Inventory, M—mean, SD—standard deviation.