Data sources
asthma
ASTHMA, ASTHMA
We pooled individual-level data from two double-blind, placebo-controlled trials of mepolizumab for severe asthma: the Dose Ranging Efficacy And safety with Mepolizumab (DREAM, 2009/11–2011/12), and the Mepolizumab as Adjunctive Therapy in Patients with Severe Asthma (MENSA, 2012/10–2014/01) studies [During the 52-week DREAM study, 621 patients were randomly assigned (in a 1:1:1:1 ratio) to receive one of the three doses of intravenous mepolizumab (75 mg, 250 mg, 750 mg) or matched placebo every 4 weeks. During the 38-week MENSA study, 576 patients were randomized (in a 1:1:1 ratio) to receive placebo, a 75 mg intravenous dose, or a 100 mg subcutaneous dose of mepolizumab, every 4 weeks. Both studies had similar inclusion criteria related to clinical diagnosis, eosinophilic asthma, and lung function, with details provided in 