Cost-effectiveness analysis
death, syncope
EVENTS
Anonymised electronic healthcare record data will be sent to our health economist in Sheffield to apply unit costs and tariffs, to estimate within trial costs and QALYs, and then to undertake lifetime economic modelling. Both within trial and lifetime cost-effectiveness analysis will be performed. In within trial analysis, costs will be estimated by applying national unit costs to items of resource use (monitoring, hospitalisation, treatment, health and social care) to estimate the mean cost per participant in each arm of the trial. Cost-effectiveness will then be estimated as the incremental cost per syncope episode avoided and the incremental cost per QALY gained, with QALYs being estimated from EQ-5D questionnaires. Lifetime cost-effectiveness will be estimated using decision analytic modelling from published sources of life expectancy, annual costs and corresponding annual utilities. This will explore the potential impact of events, such as syncope episode resulting in death or injury, that have consequences beyond the timeframe of the trial.