Data availability
The trial protocol is provided in the Supplementary Information file. Deidentified clinical data for individual patients supporting the results of this manuscript are included within the manuscript and its Supplementary files. To ensure patient privacy, further deidentified data are not publicly available, but can be accessed upon a scientifically justified request to the corresponding author, Xiaojia Wang (wxiaojia0803@163.com), for up to 10 years after this paper’s publication. The corresponding author will review all data requests to ensure its scientific use, and upon approval, de-identified patient data will be shared within three months. The raw sequence data reported in this paper have been deposited in the Genome Sequence Archive in National Genomics Data Center, China National Center for Bioinformation/Beijing Institute of Genomics, Chinese Academy of Sciences (GSA-Human: HRA005624) and are publicly accessible at 