Participating centers
DEL
The following centers are actively recruiting for the trial:
Careggi University Hospital of Florence, Florence, Italy; Germans Trias i Pujol, Badalona, Spain; Federico II University of Naples, Naples, Italy; Udine Hospital, Italy; Fondazione IRCCS Ca' Granda, Milano, Italy; Brescia Hospital, Italy; Pisa University, Italy; IRCCS AUOBO University of Bologna, Bologna, Italy; Policlínico Gemelli, Rome, Italy; Gregorio Marañon, Madrid, Spain; Basurto, Bilbao, Spain; Puerta del Mar, Cadiz, Spain; Alvaro Cunqueiro, Vigo, Spain; Clinic, Barcelona, Spain; Complexo Hospitalario Universitario de A Coruña (CHUAC), Spain; Ospedale Infermi di Rimini, Rimini, Italy; Policlinico Universitario di Modena; Bolzano Hospital, Ospedale dei Bambini “V. Buzzi” Milan, Italy.We estimate that the participating centers will have a minimum of 10 and a maximum of 70 eligible patients during the study period in order to have a final sample size 668 children (334 per arm). Sample size calculation and trial simulation have been performed with R (see below).The study will be carried out in third or fourth level NICUs in which medical staff is adequately trained to use LU and quantify RDS severity with LUS.