3. Results
hypoglycemic
TYPE 1 DIABETES
Twenty patients with type 1 diabetes, aged 20–61 years, were recruited and completed this study. No severe hypoglycemic or hyperglycemic episodes occurred during the study. The characteristics of the patients enrolled in this study are illustrated in All patients were adherent and wore the sensor more than 70% of the time during each study phase. Glucose metrics collected at baseline and after using the two algorithms are shown in Three patients (15%) had a TIR > 70% at baseline, whereas five (25%) and twelve (60%) patients had a TIR > 70% after two weeks of using Algorithms 1 and 2, respectively.The mean insulin dose injected before meals was 15 ± 5 units with Algorithm 2 and 16 ± 6 units with Algorithm 1 (We then divided the participants according to the therapy regimen, MDI or CSII, and again compared the glucose metrics collected at baseline and the end of the two study phases. The results are displayed in In patients treated with MDI therapy, we found a statistically significant difference in TIR and TBR collected at baseline and after the two study phases. However, TBR was no longer significant (In patients treated with CSII, TIR, TAR, mean glucose, SD, CV, and GMI were statistically different across the three timepoints of this study. In the post hoc analysis, the same variables differed significantly between Algorithm 2 and the baseline, while Algorithm 1 differed in TIR and TAR when compared to the baseline. Algorithm 1 and Algorithm 2 differed in TIR, TAR, and SD.