Ocular surface disease index
dry eye disease
DISEASE
The OSDI correlates well with other measures of disease severity in dry eye disease and has been found suitable as a surrogate measure of disease severity in clinical trials. Changes in scores on this 100-point scale based on patient responses to the 12-item questionnaire were in line with other assessments in this study. The higher dose of MNP Cyclosporine was statistically superior to Restasis™ after 12 weeks of treatment with either product in per-protocol analysis. While results with the lower dose of the test product did not reach statistical significance in comparison to the control group, results of the higher and lower dose groups of test product could also not be statistically separated. Analysis of covariance with baseline value as covariate confirmed statistical superiority of the higher dose of MNP cyclosporine over the control group in the PP population. OSDI values at baseline and after 12 weeks of treatment are shown in Table 