Study treatment
tumour, RCC
TUMOUR, RCC
In phase 1b, the starting dose level for ibrutinib was 560 mg orally once daily. Ibrutinib 560 mg was combined with everolimus 10 mg orally once daily (RCC cohort), docetaxel 60‒75 mg/mFollowing the determination of the RP2D by a Dose Level Review Committee (DLRC), additional patients were enrolled and treated in phase 2 at the RP2D to further evaluate the efficacy of the regimen for each specified tumour type as prespecified.