Improvement in subjects’ clinical indicators after postbiotic gel application
Vulvar pruritus, vaginal itching, vaginitis
VAGINAL INFLAMMATION, REMISSION, VAGINITIS
In our study, 50 people completed clinical indicators, including 45 people who completed vaginal discharge collection before the intervention and 42 people after the intervention. After matching, the per-protocol population was 42, who completed the process of clinical information collection and provision of vaginal secretion for microbiota sequencing analysis before and after using the postbiotic gel. The vaginal sample of a healthy woman is transparent or milky white, with no odor and in a small amount. A large amount of vaginal secretion that is thin, homogeneous, and of fishy odor is indicative of vaginal inflammation (Changes in vaginal secretion properties and biochemical parameters after the use of postbiotic gel.Vulvar pruritus is one of the reference indicators for evaluating vaginitis. Three among the 50 patients in this study complaint about vaginal itching at the start of the trial, and the symptom remained only in one subject after using the postbiotic gel. A high level of vaginal secretions cleanliness (the cleanliness rating is closer to IV) and positive reaction in hydrogen peroxide test indicate poor BV or at least poor vaginal health. Initially, 47 patients showed a positive result for hydrogen peroxide, and 18 (remission rate = 38.3%) of them showed a negative hydrogen peroxide result after using the gel. Moreover, 29 people had a cleanliness grade of III or IV, and most (18) of them showed significant improvement after using the postbiotic gel. These data suggested that applying the postbiotic gel for a week could improve BV and vaginal health.