Carriers of the I allele versus D/D homozygotes
Due to the low frequency of ACE I/I homozygotes and to ensure a more balanced genotype distribution in the statistical analysis, a sub-analysis, in which carriers of the I allele were combined into a single group (I/ +), was conducted. Patients with the ACE D/D or I/ + genotype had similar gender and ACE inhibitor treatment distribution and were comparable in age, height, weight and BMI (Table Patients allocated to exercise training.Anthropometrics are presented as means ± standard deviation, and dichotomous data are expressed as numbers (percentages) in patients with the ACE D/D or ACE I/ + genotype. BMI: body mass index. The Combining carriers of the I allele into one group did not significantly alter the results for any of the obtained markers of exercise capacity, with between-group 