Ethics approval and consent to participate
The study protocol, patient information, and consent were approved by the ethics committee of the Kyungpook National University Chilgok Hospital on October 17, 2019 and the IRBs of all participating institutions. Furthermore, the trial is approved by the Ministry of Food and Drug Safety (2020004284) on June 04, 2020. Patients will receive information (purpose, potential advantages, risks) about the study and be asked to sign a consent prior to enrolment. Each participant will complete written informed consent before enrollment. This study complies the principles of both Declaration of Helsinki rules and the Good Clinical Practices guidelines.