Eligibility criteria {10}
Allergy, dry, pulmonary or liver disease, fatigue, diarrhea, fibromyalgia, pain, psychosis, dizziness, alcohol abuse, illicit drug abuse, obstipation
ALLERGY, DISEASE, FIBROMYALGIA, SYNDROMES, CHRONIC PAIN, OBSTIPATION
In order to be eligible for trial participation, a patient must meet all of the following inclusion criteria:
Chronic pain patients with a pain score ≥ 5 (on a scale from 0 = no pain to 10 = most severe pain imaginable) for most of the day and meet the 2010 American College of Rheumatology diagnostic criteria for fibromyalgia [A widespread pain index (WPI) ≥ 7 (on a scale from 0 to 19);And a symptom severity (SymS) score ≥ 5 (on a scale from 0 to 12) or a WPI of 3–6 and a SymS score ≥ 9.The WPI defines the number of body areas in which a patient experienced pain during the last week; the SymS score indicates the level of other core symptoms of fibromyalgia such as fatigue, non-refreshing sleep and cognitive symptoms.The following exclusion criteria are being applied:Unable to give written informed consent.Presence of medical disease that may alter the pharmacokinetics of inhaled cannabinoids or oral oxycodone such as pulmonary or liver disease.Allergy to study medication.Prolonged (> 3 months) use of strong opioids (oxycodone, fentanyl, buprenorphine, morphine) or tramadol (> 150 mg/day).Inability to taper down on previous pain medication in the 4–6 weeks prior to dosing.History of illicit drug abuse or alcohol abuse.A (family) history of psychosis.Pregnancy and/or lactation.The presence of pain syndromes other than fibromyalgia.Age < 18.The presence of autonomic complaints such as diarrhea or obstipation, dizziness, and dry mouth/eyes are no reason for exclusion in the chronic pain patient group, as these are symptoms consistent with the fibromyalgia syndrome [