Adherence
obstipation, vomiting and gastrointestinal pain
OBSTIPATION, ADVERSE EVENT
All 81 included participants remained to the 3-month follow-up. At the 3-month follow-up, 54 participants identified from the single or double dose of probiotic groups in the blinded phase were asked to continue with a higher dose of probiotics. Six participants declined further participation, two participants started the second phase, but dropped out, and one participant was excluded due to adverse event (obstipation concurrent with vomiting and gastrointestinal pain). Hence, 45 participants attended the 6-month follow-up visit.Weekly electronic questionnaires asked if capsules had been missed, and if so, how many. During the first 3 months, all participants responded to at least 11 out of 12–14 weekly questionnaires (depending upon follow-up date). During months four through six, all participants responded to at least 11 out of 12–14 weekly questionnaires (depending upon follow-up date). Responses are presented at an aggravated level in Table Reported adherence to intervention.