Serum E2 levels
As pre- and post-operative E2 levels did not conform to normal distribution, the median value was used for comparative analysis. The pre-operative serum E2 level was 84.15 pg/ml (range: 15-278 pg/ml) and 68.6 pg/ml (range: 31-282 pg/ml) in the transdermal and oral group, respectively. There was no statistically significant difference between the two groups in terms of baseline serum E2 levels (The comparison of serum estradiol levels between transdermal and oral groups. 