Parametric survival analysis
malaria
MALARIA, EVENTS
A parametric survival model, adjusted for repeated events, was developed to estimate the hazard of incident malaria from 6 to 24 months of age, during chemoprevention. The Laplace estimation method in NONMEM, version 7.4.2 was used.Model selection was guided by change in objective function value (OFV) between nested models, parameter estimates, relative standard error (RSE), and Kaplan–Meier visual predictive check.Hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated using the final parameter estimates and covariance matrices. Percent reductions in incident malaria hazard were defined as 1 – the HR. For the final models, 95% CIs of parameter estimates were determined by bootstrap (