Introduction
OHCA, cardiac arrest, comatose
CARDIAC ARREST, COMATOSE
Survival rates remain around 50% for comatose patients treated in the Intensive Care Unit (ICU) after out-of-hospital cardiac arrest (OHCA) [Adequate mean arterial blood pressure (MAP) is vital to maintain cerebral blood flow (CBF) at a level sufficient for preserving oxidative energy metabolism. Cerebral autoregulation is impaired or right-shifted in approximately 30–50% of patients following cardiac arrest [This randomized trial was designed to compare the effect of two levels of MAP on global cerebral energy metabolism in comatose patients resuscitated from OHCA. Therefore, we tested the hypothesis that higher MAP improves CBF, cerebral oxygenation and oxidative metabolism by lowering the LP ratio, during post-resuscitation care compared with lower MAP.