Ethical Considerations
This study’s protocol was approved by the institutional review board of the Renmin Hospital of Wuhan University (approval WDRY2022-K175) and registered at the Chinese Clinical Trial Registry (ChiCTR2200063550). The trial was also conducted in accordance with the Good Clinical Practice guidelines, the Declaration of Helsinki, and all applicable Chinese laws and guidelines. Written informed consent was obtained from each patient before inclusion. The trial protocol adhered to the CONSORT (Consolidated Standards of Reporting Trials) reporting guidelines (