Pharmacokinetic results
Visual inspection of the median GSK3772847 serum concentration‐time profiles for both dose levels indicated no appreciable difference across injection sites (Figure Median serum concentrations of GSK3772847 over time by dose and injection site (A, B) (PK population) and summary of median serum concentrations of GSK3772847 over time for cohorts 1 and 2 (PK population) (C). Dashed black line represents the lower limit of quantification (0.2 μg/ml). Error bars represent minimum and maximum values. PK, pharmacokinetic; SC, subcutaneousSummary of derived GSK3772847 PK parameters for cohorts 1 and 2 (PK population)Abbreviations: %CVb, between subject variability; AUC, area under curve; CI, confidence interval; 
Overall, the geometric mean GSK3772847 serum concentration‐time profiles by cohort for 140 mg SC (upper arm) were comparable, with overlapping confidence intervals (Figure Median serum concentrations of GSK3772847 over time by cohort for 140 mg SC dose (PK population). Dashed black line represents the lower limit of quantification (0.2 μg/ml). Error bars represent minimum and maximum values. PK, pharmacokinetic; SC, subcutaneous