DISCUSSION
depression
In this randomized controlled trial examining the effects of HIIT on an RNA‐based measure of biological age, participants in the HIIT group showed significant reductions in TA and TAaccel. This improvement in biological age coincided with improvements to body composition, ratings of sleep quality, and ratings of depression within the exercise group. These results suggest that exercise exerts an effect on age‐related patterns of gene expression and that such effects could potentially contribute to the positive health and longevity effects associated with exercise.