4. Discussion
obesity, diabetic diet, diabetic diets, diabetic diet improves blood glucose, diabetes
OBESITY, DIABETES
This study is the first report on the use of rare sugars in a diabetic diet and the first detailed evaluation of blood glucose trends and endogenous insulin secretory capacity in patients with type two diabetes. This study was conducted in type two diabetes patients aged between 20 and 80 years old and compared the peak PPG levels when diabetic diets containing D-allulose were consumed using isCGM. The consumption of a diabetic diet containing 8.5 g D-allulose per meal improved PPG levels in type two diabetes patients even when compared with a strictly energy-controlled diabetic diet. Serum CPR levels also tended to decrease. In a previous report, 20 healthy adults ingested D-allulose during a 75 g oral glucose tolerance test (OGTT) to check blood glucose trends and insulin levels. This study found that 5 g or more of D-allulose was required to significantly suppress blood glucose levels after glucose loading [A systematic review and meta-analysis have also been reported [Various mechanisms underlying the blood glucose-lowering effect of D-allulose have been reported. Basic research has reported the inhibitory effect of D-allulose on monosaccharide absorption in the small intestine [Owing to massive sugar consumption, alternative food has attracted considerable attention. Artificial sweeteners, which are frequently used as sugar substitutes, have been identified as potentially useful alternatives to sugar to prevent diabetes and obesity [In this study, a diabetic diet was developed in the form of a normal therapeutic diet with the addition of D-allulose to unify the total energy content. There have been several reports on the properties of D-allulose when used in cooking. For example, with regard to changes in the viscosity of food products, previous studies on egg whites with various monosaccharides showed that the flow viscosity tended to decrease with increasing content when D-allulose was added, which was comparable to Fructose and Sucrose [With regard to the safety of D-allulose, studies have shown that D-allulose can be safely consumed in healthy adults [The limitations of our study were as follows. First, this was an exploratory study, and the number of patients involved was small; therefore, the effect of D-allulose should be studied in a larger number of cases in the future. Second, we conducted this study in a controlled setting with patients in the hospital, and the duration of the study was short. Tak et al. [In this study, a diabetic diet containing 8.5 g D-allulose was found to improve PPG levels in type two diabetics compared with a normal diabetic diet. This is the first report to show in detail that a rare sugar diabetic diet improves blood glucose levels in type two diabetes patients. On the basis of these results, further analyses will be possible in the future.