Treatment delivery
ADVERSE EFFECTS
The median (IQR) number of intravenous doses of vitamin C administered was 3 (3, 6) and for placebo was 6 (3, 7). All 75 subjects received their intravenous course in hospital and 22 completed their oral course in hospital. Two subjects discontinued the oral formulation in hospital because of adverse effects (see below). An intravenous dose of vitamin C was missed in one subject (3%) and 6 (15%) subjects missed a placebo intravenous dose. Two subjects (6%) missed an oral dose of vitamin C and 6 (16%) missed an oral dose of the placebo while in hospital. Fifty-one subjects were discharged to complete the course of treatment at home. Of those discharged with oral therapy, 29 (81%) were prescribed vitamin C and 22 (56%) placebo. At follow-up, 25 of 29 (86%) taking vitamin C and 20 of 22 (91%) taking placebo reported completing their course of treatment at home.