Interleukin-1ra
cardiac injury
We observed a positive association between IL-1ra and neutrophils, but not CRP and no associations with markers of cardiac injury. The significant increase in IL-1ra in the tocilizumab treated patients could nevertheless be of relevance. Although no effect on the upstream cytokine IL-1b was found, an attenuating effect of IL-1 may be present as IL-1ra blocks the binding of both IL-1α and IL-1β to their common receptor.