Conclusions
COA, amnestic MCI
DISEASE
In conclusion, this study provides supportive evidence that the ADCS-ADL-MCI is reliable, with acceptable internal consistency (item-total correlations and Cronbach’s alphas) and moderate-to-good reproducibility. Convergent validity was demonstrated, with moderate-to-high correlations observed between the ADCS-ADL-MCI with other relevant COA measures. Further, there was strong support for known-groups validity, as evidenced by the ADCS-ADL-MCI’s ability to distinguish between various disease severity groups. Finally, the ADCS-ADL-MCI was shown to be responsive to change when patients reported change on other COA measures. This instrumentis fit-for-purpose as a key endpoint in pivotal trials and for use by clinicians in clinical practice, capable of capturing amnestic MCI patients' functional abilities in ADLs from a caregiver's perspective.