Acknowledgements
This study was funded by the Spanish Ministry of Health (grant no. PI17/01116), Instituto de Salud Carlos III, Madrid, Spain, and Laboratorios ERN, Barcelona, Spain (grant no. 19PNJ145). We thank the Spanish Clinical Research Network (SCReN), Instituto de Salud Carlos II, for its support through projects PT17/0017/0010 and PT20/000008, integrated into the ‘Plan Estatal de I + D + I’ 2013–2016 and co-financed by the European Regional Development Fund (FEDER). J.M.M. received a personal 80:20 research grant from Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, for the 2017–2024 period. O.G. received a research grant from the ‘Pla estratègic de recerca i innovació en salut (PERIS) 2019–2021’ (Departament de Salut, Generalitat de Catalunya). We also thank the CERCA Program and the Generalitat de Catalunya for institutional support. The funders did not contribute to the design or conduct of the study; collection, management, analysis or interpretation of the data; preparation, review or approval of the manuscript; or the decision to submit the manuscript for publication.