Secondary End Points
PD, death
The 24-week CBR was defined as the percentage of patients who completed 6 cycles of treatment without PD. A 90% binomial confidence interval of the CBR was constructed. The duration of response (DoR) was measured from the date of complete or partial response to the date of PD or death, whichever was earlier. Progression-free survival was defined as time from randomization to PD or death. Overall survival was defined as time from randomization to any-cause death. The distributions of PFS and OS times were estimated with the Kaplan-Meier method.