Background
leptospirosis, CKD, chronic kidney disease, interstitial disease, diabetes mellitus, ’ presenting renal function
LEPTOSPIROSIS, ESSENTIAL HYPERTENSION, DIABETES MELLITUS, INTERSTITIAL NEPHRITIS, REMISSION
Endemic chronic kidney disease of unknown aetiology (CKDu) which is prevalent in Sri Lanka and many other tropical countries rank amongst diabetes mellitus and essential hypertension in causing chronic kidney disease (CKD) [CKDu is primarily a chronic interstitial disease which may have resulted from acute or subacute, low-grade recurrent interstitial nephritis [After leptospirosis outbreaks in the dry zone of Sri Lanka in 2008 and 2011, leptospirosis was found to be endemic in a region where CKDu is also endemic [The objectives of the current clinical trial were to assess the effectiveness of prednisolone or doxycycline treatment, compared to those without such treatment, for patients presenting with AIN of unknown aetiology from CKDu endemic regions of Sri Lanka. Our hypothesis was that these treatments improve a patients’ presenting renal function, either to a complete remission (CR) 61–90 ml/min/1.73m