Translational perspective
stroke, heart failure, AF
STROKE, HEART FAILURE, ATRIAL FIBRILLATION (AF)
Early rhythm-control therapy reduces cardiovascular outcomes across the spectrum of genetic atrial fibrillation (AF) and stroke risks estimated by polygenic risk scores (PRS).The PRS for AF is moderately associated with an increase for recurrent AF while the PRS for stroke is associated with heart failure hospitalization.The association of genetic stroke risk with heart failure is replicated in the UK Biobank, highlighting the need for comprehensive care of these cardiovascular conditions.Further research into the mechanisms leading to heart failure risk associated with genetic stroke and AF risk could identify approaches for stratified therapy.