Study design, sites, and conduct
SE, malaria
ADVERSE EVENTS, MALARIA
Briefly, in this randomised, placebo-controlled trial, children aged 6 months–11 years with uncomplicated Genotyping was performed to identify the following: (i) the status of cytochrome (CYP) P450 2D6 [Follow-up extended to D42, during which investigations included symptoms (to detect adverse events), Giemsa-stained blood films, venous blood (D0, 7, 14 and 28) for a complete blood count and routine biochemistry, and HemoCue measured Hb concentrations. The latter were used to define Hb changes over time: D0, 1, 2, 3, 7, 14, 21, 28, 35, and 42; in a subset of patients who were having intense monitoring of their parasite counts, additional samples were taken at D0 H1, H1.5, H2, H4, H6, H8, H12, H36, H60, H84, and H96.The study sites, the Kinshasa Mahidol Oxford Research Unit (outside Kinshasa) and the Mbale Regional Referral Hospital (Mbale, SE Uganda), are in areas of hyperendemic, perennial malaria transmission of 