Author contributions
RECRUITMENT, RECRUITMENT
AO: Analysis of data, interpretation of data and writing manuscript. SS: Clinical co-ordinator, developed protocol, running of clinical trial, analysis of data, interpretation of data and writing manuscript. DW, SC, AMB, KM, PS, SW, CP, CT and TPe: Recruitment, patient care, interpretation of data and reviewing manuscript. JB and TPi: Translational lead, interpretation of data and reviewing manuscript. EMC: Principal trial manager and reviewing manuscript. MW: Senior trial co-ordinator and reviewing manuscript. RH: Trial statistician, analysis of data and reviewing manuscript. LH: Statistician, analysis of data and reviewing manuscript. PB-L, DC: Co-chief investigator, recruitment, patient care, design of study, running of clinical trial, analysis of data, interpretation of data and reviewing manuscript.