References
ST-segment elevation, myocardial infarction, NSTEMI, VTE, venous thromboembolism, AKI, acute kidney injury
ADVERSE EVENT, DISEASE, ACUTE CORONARY SYNDROME
Flow diagram. The flow diagram shows the number of subjects assessed for eligibility, randomized, randomized and receiving intervention, randomized and withdrawing consent before treatment initiation, and included in the primary analysis. Patients who were eligible but not randomized, who were not randomly allocated, who were lost to follow-up, and who discontinued the intervention are also reported.Changes in inflammatory markers between lactoferrin and placebo arms. CRP (Data collection frequency for the relevant parameters.Informed consentFulfillment of inclusion criteriaRandomizationMedical historyOngoing pharmacological therapiesNEWS2Need for oxygen supplementationArterial blood gas analysisNasal swab analysisRoutine hematological analysisNEWS2Vital signsP/F ratioOxygen supplementationAdverse eventsArterial blood gas analysisRoutine hematological analysisNEWS2Adverse eventsOxygen supplementationArterial blood gas analysisRoutine hematological analysisDemographic and baseline characteristics of the studied population. Data are expressed as number of patients or median (interquartile range, IQR) when appropriate. * refers to data obtained with oxygen supplementation.Abbreviations: NEWS2 = National Early Warning Score 2, ALT = alanine transaminase, AST = aspartate aminotransferase, CRP = C-reactive protein, LDH = lactic dehydrogenase.Demographic and baseline characteristics of the studied population. Data are expressed as number of patients or median (interquartile range, IQR) when appropriate. * refers to data obtained with oxygen supplementation.Abbreviations: NEWS2 = National Early Warning Score 2, ALT = alanine transaminase, AST = aspartate aminotransferase, CRP = C-reactive protein, LDH = lactic dehydrogenase.Secondary outcomes. Data are expressed as number of patients or median (interquartile range, IQR) when appropriate.Abbreviations: NEWS2 = National Early Warning Score 2, NIV = non-invasive ventilation.Lactoferrin effectiveness in driving disease evolution towards primary endpoints according to age subgroup and gender.Adverse events in the two treatment arms.Abbreviations: ACS = acute coronary syndrome, STEMI = ST-segment elevation myocardial infarction, NSTEMI = non-ST-segment elevation myocardial infarction, ALT = alanine aminotransferase, ULN = upper limit of normal (defined by local laboratory settings), VTE = venous thromboembolism, AKI = acute kidney injury.