The effect of conventional antibiotics on periodontal biofilm formation in real-time
periodontal disease, biofilm mass
PERIODONTAL DISEASE, PLAQUE
Once the most suitable conditions for periodontal biofilm transportation and growth were established, we grew subgingival biofilms of 64 patients with periodontal disease Biofilm growth derived from subgingival plaque samples grown in real time in an impedance-based monitoring system in the presence/absence of amoxicillin, metronidazole, their combination and azithromycin. Antibiotics were added at the beginning of the experiment, along with fresh subgingival plaque samples. Black lines represent antibiotic-free controls. Biofilm growth was registered every 10 minutes for 8 h; SDs are not shown for clarity. Each panel represents a different patient and are representative of cases where one of the antibiotic treatments was effective in reducing biofilm mass compared to the rest (panels 