Why not using randomization?
tumor, tumors, cancer stage
TUMOR, TUMORS, RECRUITMENT
First, in these small selected tumors group, patient cancer stage and tumor characteristics should be comparable (see inclusion criteria) but the influence of patient preferences is as important as the particular expertise of the individual treating medical team. Ignoring patient preferences can lead to recruitment problems, as shown in a recent study [Second, the final treatment depends on the MTB decision based on the NCCN and European guidelines [Finally, to minimize a potential center effect, patient’s inclusion is restricted to hospitals with an expertise in at least 2 different treatments modalities and treating minimum 50 cases/year. Moreover, a fixed center effect will be integrated in the statistical analysis.