Clinical study protocol
This study was designed as a prospective, multicenter, randomized, non-inferiority trial. It was conducted in three tertiary referral university hospitals (Soonchunhyang University, Asan Medical Center, and Chungbuk University) in South Korea. Enrolled patients were randomized into an experimental or a control group without risk stratification at a 1:1 ratio from March 15, 2021 to January 27, 2022 (Fig. Flow of presented study.