Introduction
NSCLC, tumor, cancers, cancer, prostate
TUMOR, CANCERS, CANCER, PROSTATE, HEPATOCELLULAR CARCINOMA, NSCLC
Aldo-keto reductases (AKRs) are a superfamily of NAD(P)(H)-dependent oxidoreductases that primarily catalyze the reduction of aldehydes and ketones to their corresponding alcohols [AKR1C3 is expressed in various normal human tissues, including sex hormone-dependent (e.g., testis, breast, endometrium, and prostate) and sex hormone-independent (kidney and urothelium) tissues [In a population-level survey of 2490 patients across 19 cancer types, in which tumor tissue microarrays were used to assess AKR1C3 overexpression, the highest frequency was noted in hepatocellular carcinoma, followed by bladder, breast, prostate, renal, gastric, cervical, colon, and non-small cell lung (NSCLC) cancers [OBI-3424 is a highly potent DNA-alkylating prodrug that is selectively activated by AKR1C3 (Fig. 