Author contribution
Rui Gao conceived of the study and participated in its design and is responsible for the development of clinical research. Xi Jia and Xinru Li is primarily involved in registration of clinical trials, results analysis, drafting the manuscript and substantively revising. Bing Jia is responsible for the designing and guidance of preclinical drug related experiments. Ye Yang, Ting Ji and Xin Xie are responsible for medical history collection and data processing. Yuanbo Wang and Yan Liu prepared the [