Pharmacokinetics
The pharmacokinetic parameters for M8891 for cycle 1, days 1 and 15 are presented with summary statistics in Pharmacokinetic parameters of M8891 in plasma by treatment after single (cycle 1, day 1) and multiple dosing (cycle 1, day 15)Abbreviations: AUC

Except for a few subjects (Peak and total exposures (Plasma concentration–time profiles of M8891 (mean ± SD) at cycle 1, day 1 (From day 1 to day 15 of cycle 1, M8891 showed slight accumulation across all doses. The accumulation ratio for AUC ranged from 1.99 to 2.90, in line with a terminal half-life of approximately 30 hours and once daily dosing, and the accumulation ratio for Pharmacokinetic parameters after repeated dosing generally exhibited low to moderate interpatient variability, ranging from 7.7% to 51.7%. Starting with 20 mg, steady-state C