Ethics
Prior to acceptance, the relevance and quality of the grant application were peer-reviewed by a team of (external) experts of the grant provider ZonMw. The Research Ethics Committee of the Radboud University Medical Centre in Nijmegen, The Netherlands (CMO region Arnhem-Nijmegen) judged this study not to be subject to the Medical Research Involving Human Subjects Act (in the Netherlands known by the Dutch abbreviation WMO, in full “Wet Medisch-wetenschappelijk Onderzoek met mensen), file number 2021–8221. The internal independent review board of TNO reviewed and approved the study’s compliance with laws and regulations concerning privacy sensitive data, reference number 2021–054. The study is conducted in accordance with guidelines and regulations of the Declaration of Helsinki. Prior to participation, all participants will receive information about the study and will provide informed consent. The study is registered in the ISRCTN registry, reference number ISRCTN16929184 [