Transient cytokine release upon CARVac administration.
Interferon-gamma and interferon-gamma inducible protein 10 serum levels were measured in a lymphodepleted patient prior to and following ACT of CAR-T cells (DL1, solid green line). CARVac (25 µg) dosing started 4 days post-ACT and was administered on d51, d72, and d93 (50 µg), denoted by green dashed lines. Cytokine measurements were taken prior to CARVac dosing, then 6 hr, 24 hr, and then weekly after each CARVac dose.
