MAD-H vs MAD-S
teeth and painful jaw muscles
MINOR
In the present study, there was no significant difference between the MAD-H and MAD-S in affecting the AHI-supine, as well as AHI and AHI-non-supine. According to the post hoc power analysis, the effect size f of the AHI-supine was 0.29 in the PP analysis and was 0.10 in the ITT analysis, which is qualified as small to medium (an effect size f = 0.10 is small, one = 0.25 is medium, and one = 0.40 is large [No significant difference was found between both MADs in changing the upper airway dimensions. With the same protrusion position and vertical opening, the same effect of MAD-H and MAD-S was applied to the tongue and mandible in the awake state, and thus no difference of upper airway changes could be found between both groups. Our results are similar to the outcomes of two previous studies based on cephalometric images [The self-reported side effects were not significantly different between both MAD groups. However, sensitive teeth and painful jaw muscles were 3–4 times more frequent in the MAD-H group compared to MAD-S group, which might be due to the different design feature. However, it seems that the side effects of MAD in most cases were of a minor nature and probably improve in the longer term [