Introduction
CKD, chronic kidney disease, skeletal muscle dysfunction, a loss of functional independence and frailty, mitochondrial dysfunction
MITOCHONDRIAL DYSFUNCTION, PATHOGENESIS
Patients with chronic kidney disease (CKD) suffer from a loss of functional independence and frailty (Coenzyme Q10 (CoQ10) is a fat-soluble coenzyme involved in the transfer of electrons from complex I and II to complex III in the mitochondria during oxidative phosphorylation (Nicotinamide riboside (NR), a precursor to NADGiven the central role of mitochondrial dysfunction in the pathogenesis of kidney related skeletal muscle dysfunction (