Cost-effectiveness Acceptability Curve
The figure shows the probabilistic sensitivity analysis using Monte Carlo simulation with 10 000 iterations, in which the input parameters varied simultaneously in the plausible statistical distributions that reflected the uncertainty of the cost-effectiveness for ON101 with general wound care (GWC) vs GWC alone at different willingness to pay thresholds. ON101 with GWC had a 28.7%, 59.7%, and 81.8% probability of being cost-effective against the willingness to pay thresholds of $0, $32 787, and $98 361 per quality-adjusted life-year (QALY) gained, respectively. ICER indicates incremental cost-effectiveness ratio.