Participants
COLD
Between February 2018 and February 2019, we screened 23 young, healthy, male volunteers and measured cold-induced thermogenesis (CIT). In 16 subjects the basal metabolic rate increased by at least 5% in response to cold exposure. Only those were enrolled into the clinical trial. Participants were randomly assigned to a treatment sequence (placebo first or prednisone first). The two sub-groups did not differ in terms of baseline characteristics (Clinical characteristics at baseline.All results are given as mean and 95% CI. The participants were equally randomized into the allocated group, multiple t-test comparison did not reveal any differences.