IVT with alteplase and lesion evolution
REGRESSION
The median lesion and non-hemorrhagic volumes after 24 hours in the patients that received IVT (27 (IQR: 9.2–78) ml and 24 (IQR: 9–77) ml, respectively) and in those that underwent direct EVT (24 (IQR: 9.1–57) ml and 24 (IQR: 9.1–53) ml, respectively) were not significantly different (p = 0.87, p = 0.94, respectively). Similarly, the lesion and non-hemorrhagic volumes after 1 week were similar between patients with and without IVT (41(IQR: 13–92) ml vs. 31 (IQR: 12–120); p = 0.71 and 40 (IQR: 13–90) ml vs. 31 (IQR: 12–120) ml; p = 0.72, respectively). Furthermore, there were no significant differences in the late lesion and non-hemorrhagic growth between patients with and without IVT (7.1 (IQR: −0.94–19) ml vs. 8.7 (IQR: −0.53–33) ml p = 0.59 and 9.2 (IQR: −0.41–23) ml vs. 8.7 (IQR: −0.53−32) ml p = 0.84, respectively). Details of the lesion characteristics are provided in Univariable linear regression showed no significant association between IVT and late lesion growth (β = 5.1 (95% CI: -8.8–19), p = 0.47) and late non-hemorrhagic growth (β = 4.0 (95% CI:-9.7–18), p = 0.56). Furthermore, IVT was not statistically significantly associated with presence of late lesion growth >0 ml (OR: 1.24 (95% CI: 0.57–2.74, p = 0.59) and late non-hemorrhagic growth >0 ml (OR: 1.00 (95% CI:0.45–2.23, p = 1.00).