TRIAL DESIGN
This single-center, split-mouth, randomized clinical trial was conducted at the Department of Orthodontics, SRM Dental College, Ramapuram, Chennai, India. The protocol for the human clinical trial and the methods were approved by the Institutional Review Board and Institutional Ethical Committee, SRM University. The trial was registered in the Clinical Trials Registry, India (ICMR NIMS) with the registration number CTRI/2019/10/021718.