NanoString analysis of resected tumors
Nivo+CT, cancer, tumors
CANCER, TUMORS
To further characterize the immune composition of tumors treated with neoadjuvant chemoimmunotherapy and evaluate the impact of Ipi on the phenotype of tumor-infiltrating immune populations, we performed gene expression analysis by NanoString of resected tumors from patients treated with Nivo+CT and Ipi+Nivo+CT. We observed overall favorable immunological changes in tumors from the Ipi+Nivo+CT arm. Cell type scores for immune cells (CD45Analysis of differentially expressed genes in responders (MPR) to Ipi+Nivo+CT compared to Nivo+CT showed an enrichment of genes associated with TLS formation, cytotoxic molecules and memory T cell markers, all of which have been shown to be associated with a favorable clinical outcome in patients with cancer treated with immune checkpoint therapies (Extended Data Fig. 