Tumor response
tumor, acinar cell cancer, fatigue, fracture, NSTEMI, CAD
GASTROINTESTINAL STROMAL TUMOR (GIST), TUMOR, ADVERSE EVENTS, DISEASE, ST SEGMENT ELEVATION MYOCARDIAL INFARCTION, CONGESTIVE HEART FAILURE, CORONARY ARTERY DISEASE, CAD
Thirty patients (86%) were evaluable for treatment efficacy and tumor response. Five patients discontinued protocol therapy prior to the first scan and were not evaluable. Two patients discontinued therapy due to adverse events possibly related to study treatment, one patient with grade 3 fatigue possibly related to riluzole or sorafenib, and one patient with grade 4 troponin elevation, grade 4 non-ST segment elevation myocardial infarction (NSTEMI), and grade 3 congestive heart failure in the setting of a prior history of coronary artery disease (CAD). The remaining three patients discontinued therapy for non-treatment related reasons, including 1 patient who discontinued treatment due to a hip fracture that was unrelated to treatment, and 2 patients who were discontinued due to protocol nonadherence. Eleven patients (36%) experienced stable disease. The median time from on study to date of progression was 106 days (range 51–240 days) or 3.5 months (range 1.7–8.0 months). Only one patient had stable disease for over six months, a patient with a metastatic gastrointestinal stromal tumor (GIST) previously treated with imatinib, nilotinib, and sunitinib who was on protocol therapy for 8 months before progression. Eighteen patients (51%) experienced progressive disease. One patient with metastatic pancreatic acinar cell cancer experienced a partial response lasting 264 days (8.8 months) (