Introduction
addictive disorders
RECRUITMENT
A hallmark of the neurobiological basis of addictive disorders is an altered recruitment of the brain’s reward system (Adinoff Regarding pharmacological treatment options for AUD, baclofen — a gamma-amino-butyric acid-To date, three recent meta-analyses assessed the efficacy of baclofen of which two found evidence for significant efficacy of baclofen in AUD with a higher percentage of abstinent patients at the study end and a longer time to lapse compared to placebo (Pierce et al. It is assumed that AUD leads to a downregulation of the GABAergic system and simultaneously to an alteration of fronto-striatal information processing (Beck et al. In our current study, we investigated whether baclofen modulates the neural activity during rewarding cues in general. The applied slot machine paradigm (Lorenz et al. 