Statistical analysis
delirium, SD, pain
EVENTS, HEMODYNAMIC INSTABILITY
The Primary endpoint was intraoperative remifentanil consumption. Secondary endpoints include intraoperative hemodynamic instability events, awakening time, pain score, fentanyl consumption and incidence of delirium in the PACU, and perioperative changes in inflammatory and immunologic markers, including IL-6 and NK cell activity.As intraoperative remifentanil consumption in both groups was the primary endpoint in this study, the sample size was determined based on the results of the opioid consumption (mean ± SD = 3.5 ± 2.4 vs. 5.1 ± 2.4 mg in the SPI vs. the conventional groups) in a previous report by Won et al. [The SPSS software version 18 (SPSS Inc., IBM, Chicago, IL, USA) was used for statistical analysis. Continuous data included age, weight, height, anesthesia time, awakening time