Authors’ contributions
HL
XJ, HC1, ZZ, HZ, JN, and YD designed the study. HJ, JM, MW, HC2, XL, CL, JL CL, YH, XZ, HZ, and YD performed the clinical trial. JM, HZ, JN, and YD analyzed the data. HJ, HZ, and YD wrote and edited the manuscript as well as composed the figures. BH, TX, GL, AD, BL, RG, HL, and ZW synthesized the drug and assisted in this study. ZZ edited the manuscript. All authors approved the final version of the manuscript.