Ethics approval and consent to participate
All participants provided written informed consent. The study was approved by the ethical committee of the FAU situated in the medical faculty (22_20B, date 11.02.2020; Chair: Prof. Dr. med. Renke Maas). The study was registered at ClinicalTrials.gov (identifier: NCT04362514; 27/04/2022) and followed the principles set out in the Helsinki declaration.