Local Response of Lesions Receiving Intratumoral Glycopyranosyl Lipid A in Stable-Emulsion Formulation
tumor
DISEASE, TUMOR, BEST
A, Spider plot demonstrating change from baseline of tumor size and its durability beyond the trial period. B, Best percent change (which was at the end of follow-up time point for all patients) by cohort and histologic subtype.To analyze the contribution of IT GLA-SE in combination therapy, we identified 3 patients with evaluable concomitant lesions during the trial follow-up period who received radiotherapy alone or no local therapy. Although other patients also had multiple sites of disease, they lacked lesions that underwent radiotherapy alone during the trial follow-up period. Durable local responses were observed only in irradiated lesions that also received IT GLA-SE. By pooled mean percent change at last follow-up, lesions treated with IT GLA-SE and radiotherapy had deep size reductions (−69%), single-modality irradiated lesions also decreased (−39%), and untreated lesions increased (+69%) (