1. Introduction
ovarian failure, sleep disorders
OVARIAN FAILURE, DYSFUNCTION
Perimenopause is defined as the period of time before and after menopause. It is suggested that the onset of menopause is associated with the ovarian failure and decreased estrogen, leading to hypothalamic-pituitary-ovarian (HPO) dysfunction and central nervous system involvement [Melatonin, primarily synthesized in the pineal gland, is an endogenous hormone, and its synthesis and secretion follow a circadian rhythm, which is inhibited during the day and stimulated at night [Therefore, this study aimed at probing into the impacts of 3 mg melatonin daily in perimenopausal women. We speculated that melatonin treatment could help perimenopausal women relieve climacteric symptoms, mood, and sleep disorders and further improve their quality of life (QoL).