2.3. Inclusion criteria
pain
CHOLINERGIC URTICARIA, HYPOHIDROSIS
Male and female subjects aged ≥ 18 years and ≤ 50 years at the time of obtaining consent.Patients with severe dermal pain induced by thermal sweating stimuli (e.g., bathing), regardless of the presence or absence of cholinergic urticaria and hypohidrosis.Patients who have had symptoms of dermal pain for more than 3 months.Patients with a dermal pain degree ≥ VAS 60 mm in their daily life during the 2 weeks before obtaining consent.Patients who have not changed drugs* that may alleviate symptoms during the 2 weeks before obtaining consent and have no plans to change drugs until the end of this study (including injections, oral medications, and topical medications). The asterisk refers to antihistamines, H2 receptor antagonists, leukotriene receptor antagonists, antipyretic analgesics, narcotics, antipsychotics, and drugs acting on the central and peripheral nervous systems.Patients whose consent for participation in this study can be obtained in writing.