Intervention
hypoglycaemia
HEART, HYPOGLYCAEMIA
Following the baseline hyperinsulinaemic–hypoglycaemic clamp study, participants entered a 4 week intervention period. All participants used RT-CGM, in addition, those in the HIIT group carried out a 20 min HIIT programme on a stationary exercise bike three times a week. Each exercise session in the HIIT programme consisted of 5 min of gentle warm up cycling followed by 4×30 s cycle sprints (with 2 min active recovery after each sprint) followed by a 5 min cooldown, with the aim of achieving ≥90% of the peak heart rate obtained during the During the intervention period, all participants attended a weekly study visit (visits 4–7) to download RT-CGM data and receive advice as required on insulin dosing to optimise blood glucose levels and aid hypoglycaemia avoidance. Heart rate data were downloaded from participants in the HIIT group to ensure that their target heart rate (≥90% peak) was reached during the exercise sessions.There was a 4 to 7 day break at the end of the active intervention period prior to the second, matched hyperinsulinaemic–hypoglycaemic clamp study (visit 8). This was to avoid any lasting effect from the final exercise session.