Pleiotropy and sensitivity analysis
REGRESSION, -11
We employed MR‒Egger regression to assess the potential pleiotropic effects of IVs. The intercept term in the MR‒Egger regression can be used to indicate whether horizontal pleiotropy affects the results of the MR analysisThe beta value and odds ratio (OR) show the kind of relationship between exposure variables and outcome variables. A correlation of P < 0.016 for the beta value (0.05/3 exposures) was considered to be significant, and a correlation between p > 0.016 and < 0.05 was considered to be a suggestive correlation. The threshold of p < 0.05 was used in all sensitivity analyses. Investigations were carried out with the MendelianRandomization, TwoSampleMR and MR-PRESSO packages in R version 4.1.2 (2021-11-01)