Ethics approval and consent to participate
After institutional review board evaluation approval for this study and all experimental protocols was given by the local ethics committee (Ethikkomission Technical University Dresden, IRB 00001473, IOGR 00001076 registered at Office of Human Research Protection) under EK 101032016. All methods were carried out in accordance with the Declaration of Helsinki and its relevant guidelines and regulations. Written informed consent was obtained from all participants prior to enrollment. The study protocol was registered in the US National Institutes of Health’s database (