Discussion
delirium, postoperative delirium, postoperative nausea and vomiting, neurotransmitter deficiency, Delirium, PONV, hypertension
ADVERSE EVENTS, DISEASE, OXIDATIVE STRESS, HYPERTENSION, COMPLICATIONS
The aim of our trial was to see whether postoperative DEX given by PCIA can reduce the development of postoperative delirium in elderly patients. Data from 236 patients were analyzed, and it was found that 3.4% (4 of 117) of group D and 10.1% (12 of 119) of group C had POD, which is statistically significant. DEX given by postoperative intravenous patient-controlled analgesia may thereby lower the incidence of POD in elderly patients. DEX can significantly reduce the incidence of postoperative nausea and vomiting without increasing adverse events, but it cannot reduce the incidence of no-delirium complications or shorten the length of stay.Pervious [POD can increase morbidity and mortality, lengthen hospital stays, lead to poor functional recovery, and result in long-term decrease in cognitive function. Delirium is a complicated process, and Maldonado JR highlighted the main seven proposed mechanisms, which include neuroinflammatory, neuronal aging, oxidative stress, neurotransmitter deficiency, neuroendocrine, diurnal dysregulation, and network dysconnectivity [DEX is a kind of imidazole derivatives, which is a specific, highly selective αIn our study, no increase in the incidence of adverse events was observed in the DEX group, might be due to the small doses used, whereas the incidence of hypertension was significantly reduced in patients who received DEX. There was no difference between the two groups in postoperative cardiovascular problems, indicating that this amount is safe. In our study, DEX decreased the occurrence of PONV substantially. According to a meta-analysis [The study has the following limitations. For starters, we did not gather information on the intensity and duration of delirium. Second, owing to the fluctuating nature of delirium, it may occur outside of the time frame we evaluate, resulting in insufficient data collection. However, our evaluators reviewed the nurse's record to see whether any patients had delirium during this period. Third, this study was a single-center study. The results may be biased due to constraints in disease type, sample size and other variables, and additional investigation is required.