4. Discussion
cancers, tumor, CRC, head and neck squamous cell carcinomas, TCGA, malignant tumor
CANCERS, METASTASIS, TUMOR, PROLIFERATION, MALIGNANT TUMOR, COLD
It’s known that CRC is a common malignant tumor with high incidence and mortality.In previous studies, miRNAs have been proved to be good prognostic biomarkers in various cancers. The study reported that immune-related miRNA signature could be used to effectively predict the prognosis of head and neck squamous cell carcinomas.It’s well known that CRC metastasis was a crucial prognostic factor, but the roles of the 5 miRNAs in CRC metastasis were not clear. Due to this, the expression levels of the 5 miRNAs were compared between SW480 and SW620. The result showed that the miRNAs were all down-regulated in SW620 expect for miR-200c-5p, which indicated these miRNAs might participate in CRC progression and metastasis. Studies have reported that miR-328-3p was down-regulated in CRC and could inhibit CRC proliferation and metastasis via inhibiting the PI3K/Akt signaling pathway.Immunotherapy is a novel anti-cancer method and has been a focal point in various cancers, recently. However, CRC is regard as a cold tumor, which less responses to immunotherapy.To date, immune microenvironment was considered to be an important role in development and treatment in cancers. Recently, accumulating studies has revealed that m6A methylation could regulate tumor immune microenvironment, which led to occurrence and progression in various cancers.Since studies reported miRNAs could affect drug resistance,However, there are several limitations should be considered in this study. Firstly, risk score still needs to verify in more external cohort. Secondly, the clinical information of TCGA cohort is not complete, so some CRC samples were excluded, which might affect research results.