Procedures
ANL
ADVERSE REACTIONS, DISEASE
The patients were randomly divided into the ANL group (n = 27) and the ANL+S-1 group (n = 27). Patients in the ANL group were treated with 10 mg of ANL once a day for 14 days. The ANL+S-1 group was treated with 10 mg of ANL once a day and 40 mg of S-1 twice a day. Both drugs were taken continuously for 14 days, discontinued for one week and repeated every 21 days. The two groups were treated with drugs until the disease progressed or could not tolerate adverse reactions. For patients who could not tolerate adverse reactions, the dose of ANL was reduced to 8 mg daily. The curative effect was evaluated by magnetic resonance imaging (MRI) or computed tomography (CT) every 6 weeks.