Metabolic dysfunction is pronounced postprandially in patients with 
NAFLD, T2D, cirrhosis
CIRRHOSIS
We found significant differences in the metabolic response to the standardized mixed meal between patients with NAFLD, cirrhosis and healthy participants, and these differences were most pronounced in patients with cirrhosis.Postprandial glucose concentrations were higher in both NAFLD and cirrhosis compared to healthy. In NAFLD and cirrhosis, glucose increased for up to 90 min after the meal intervention while concentrations normalized to baseline within 60 min in healthy. Postprandial iAUC for glucose was higher in NAFLD and cirrhosis compared to healthy, with a 2.8‐fold increase in NAFLD and a 3.8‐fold increase in cirrhosis. These findings indicate impaired postprandial glucose regulation in NAFLD and cirrhosis, although none of the patients in the postprandial groups had T2D. However, likely reflecting that these individuals may be characterized as having pre‐diabetes. When investigating peak glucose concentrations in the groups, we found highest peak concentrations in cirrhosis that were statistically significantly different from NAFLD and healthy. (Table Total AUC, incremental AUC, and peak concentrations in fasting and postprandial study groups for glucose, C‐peptide, insulin, glucagon and FGF21.
Abbreviation: FGF21, Fibroblast‐growth‐factor 21.Healthy vs. NAFLD, NAFLD vs. cirrhosis, Healthy vs. cirrhosis, Healthy vs. cirrhosis, 