DISCUSSION
decline of cognitive function, MCI, aMCI, MR, AD
DISEASE, PATHOGENESIS, PATHOLOGY, DISEASES
Early diagnosis of MCI and timely clinical intervention may slow down further decline of cognitive function and progression to AD (Livingston et al., Radiomics is a promising technology that emerged in recent years, which improves the diagnosis and prediction efficiency of diseases by extracting a large number of radiomic features of target organs (H. Yang et al., Accumulating evidence suggests different imaging abnormalities related to AD follow a consistent trajectory during the pathogenesis of the disease, and that the first changes can be detected years before the disease manifests clinically (Pievani et al., Recently, automatic‐aided diagnoses of AD and MCI based on ROI techniques, voxel‐based morphometry and volumetric analysis, have gained increasing popularity (Chen et al., In clinical settings, as a conventional MR sequence, 3D‐T1 imaging is widely used in routine brain examination. Owing to the performing results of neuropsychological scales are unstable and require a high degree of patient cooperation (Guo et al., However, there are several limitations in the present study. First, this study was a single‐center study with small sample sizes, and multi‐center with large samples external validation is further needed. Second, this study is based on the Chinese community population, the results may not generalize to other ethnic groups due to ethnic differences. Although the study only examined the frontal lobe, available evidence indicates that the frontal lobe pathology occurs during aMCI and AD progression. Finally, the study lacked an AD patient group.