Angiogenesis and blood vessel density are predictive of clinical response to camrelizumab plus apatinib in cohort 2
NASOPHARYNGEAL CARCINOMA
Given that the response rate of camrelizumab plus apatinib in cohort 2 (PD-1 inhibitor-resistant) was much lower compared with cohort 1 (PD-1 inhibitor-naive), suggesting that there is significant heterogeneity among patients in these cohorts, possibly due to variances in immune microenvironments and vascular density. These factors contribute to the variability in patient response observed in our study. In order to explore the mechanism of PD-1 inhibitor resistance in patients with advanced nasopharyngeal carcinoma, we analyzed the baseline sequencing data in two cohorts. Compared with the patient in cohort 1, differentially expressed genes such as 