Randomisation and blinding
Randomisation was carried out at the baseline visit as described in the study protocol and statistical analysis plan. The three therapies were allocated in random order according to six possible treatment orders: ABC, ACB, BAC, BCA, CAB, CBA. Drugs were blinded by over-encapsulation (Tayside Pharmaceuticals, Dundee, UK) with allocations blinded to the participants, study team, study researchers, and study statistician.