Statistical analysis
PRS, death
Descriptive statistics present mean and standard deviation or median and interquartile range (IQR) for metric variables and frequencies and percentages for categorical variables. We visually checked if the continuous genetic risk was approximately normally and equally distributed and the categorized genetic risk was equally distributed across treatment groups. For visualization of time-to-event endpoints, we used Aalen Johansen cumulative incidence estimators to account for the competing risk of all-cause death.PRS was assessed as a standardized continuous variable, first. Additionally, patients were grouped into low (quintile one), intermediate (quintile two to four), and high genetic risk (quintile five) for PRS-AFThe interaction term was removed when the interaction 