Outline of simulation experiments
STD
To assess the method’s average behavior, we perform a simulation study. The general setup adopted here is similarly designed to the simulation experiments from [We compare four dose-finding algorithms that mainly differ in the enrollment schedule of patients with the same number of total patients. Additionally, we want to explore the “Exploration-Exploitation Dilemma” [The four algorithms are denoted as (1) FSAD (acc); (2) FSAD (std); (3) CSAD (acc); and (4) CSAD (std). The first two algorithms are fully sequential adaptive designs with accelerated and standard dosing strategies, respectively, whereas the third and fourth ones are cohort sequential adaptive designs with a cohort size of three 