Introduction
Sertan, PFAPA, fever, adenitis, pharyngitis
ADENITIS, APHTHOUS STOMATITIS, PERIODIC FEVER SYNDROME, SYNDROME, PHARYNGITIS, PATHOGENESIS
Edited by: Li-Tung Huang, Kaohsiung Chang Gung Memorial Hospital, TaiwanReviewed by: Andrea Trombetta, IRCCS Local Health Authority of Reggio Emilia, ItalySoner Sertan Kara, Adnan Menderes University, TürkiyeShokoufeh Ahmadipour, Lorestan University of Medical Sciences, IranWei Te Lei, Hsinchu Municipal MacKay Children’s Hospital, TaiwanPeriodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome (PFAPA) is the most frequent periodic fever syndrome in children. Its pathogenesis is still unknown, but some disease-modifying factors were observed. Several medications were tested for the long-term prophylaxis of inflammatory flares; however, none are standardly used.