Most informative time points and cell populations associated with protection against colonization.
This study identified the immune cell populations and sampling time points that are the most informative for follow-up studies. Especially in the early days after bacterial challenge (D1, D3, and D4), changes in the innate immune compartment were detected. Changes in the adaptive immune response can be monitored at various time points during the 2 weeks after challenge, with D1, D3, D11, and D14 being most informative. The most informative time points and cell populations to follow up on after bacterial challenge are summarized in 