Efficacy
LBCL, PD, B-Cell, DLBCL
DISEASE PROGRESSION, DISEASE, B-CELL LYMPHOMA, DIFFUSE LARGE B-CELL LYMPHOMA
All 157 patients were efficacy and safety evaluable. The ORR per IRC using Lugano criteria was 63.1% (n/N = 99/157; 95% CI, 55.0 to 70.6), and the CR rate was 38.9% (n/N = 61/157; 95% CI, 31.2 to 46.9). Efficacy outcomes are summarized in Table Summary of Efficacy End Points (per IRC; Lugano Criteria) in Patients With Large B-Cell LymphomaEfficacy results (per IRC; Lugano criteria) with epcoritamab in patients with LBCL. (A) shows best percentage change in sum-of-product perpendicular diameters of target lesions for patients with LBCL. Asterisks represent patients with prior exposure to CAR T-cell therapy. (B) shows the Kaplan-Meier curve for DOR. Results were similar in the DLBCL population (data not shown). (C) shows the Kaplan-Meier plot of PFS. A PFS ad hoc analysis using the Mantel-Byar approach showed a hazard ratio (95% CI) for patients with CR versus nonresponders of 0.11 (0.04 to 0.25) and a hazard ratio (95% CI) for patients with PR versus nonresponders of 0.47 (0.26 to 0.86). Thirty-six patients had disease progression (n = 28) or died (n = 8) within the first 6 weeks of treatment. Data cutoff: January 31, 2022. CAR, chimeric antigen receptor; CR, complete response; DLBCL, diffuse large B-cell lymphoma; DOR, duration of response; IRC, independent review committee; LBCL, large B-cell lymphoma; PD, progressive disease; PFS, progression-free survival; PR, partial response; SD, stable disease.The median PFS was 4.4 months (95% CI, 3.0 to 7.9; Fig Concordance between the IRC and investigator assessments was high at 82.8% (kappa: 0.77 [95% CI, 0.69 to 0.84]; Data Supplement). For key subgroups, benefit with epcoritamab was consistent with that of the overall population (Figs Response (per IRC; Lugano criteria) in prespecified subgroups of patients with LBCL. (A) ORRs. (B) CR rates. Data cutoff: January 31, 2022. 