The effect of the GRIN2A variant resembles the differential effect of ketamine versus midazolam
To assess the similarity between the effect of the GRIN2A variant on the one hand and the pharmacological effect of the NMDAR antagonist ketamine as well as the GABA-A receptor agonist Midazolam on the other hand, we conducted a correlation analysis using the averaged second level connectivity changes associated with the genetic variant and the respective pharmacological contrasts. Correlation curves revealed a positive correlation between the SNP effect and the effect of ketamine—both as compared to placebo and compared to midazolam (Fig. 