Sorafenib Cmin,ss values at dose escalations and riluzole trough concentrations at different time points.
(Plasma riluzole levels achieved steady state after eight days of continuous dosing and no riluzole accumulation was observed through multiple doses (No significant difference in the population mean of riluzole Cmin,ss was observed in patients treated across dose levels with different doses of sorafenib as analyzed by ANOVA analysis at a significance level of 