Results
MISCARRIAGE
A total of 181 tNC- FET were analysed. The mean age was 35.37 ± 4.72 in patients with serum progesterone concentrations ≥10 ng/mL on the day of ET and 35.35 ± 5.3 years in patients with serum progesterone concentrations <10 ng/ml on ET day. Overall, 49.7% (90/181) of patients had adequate serum progesterone concentrations on ET day (≥10 ng/mL). Patients with serum progesterone concentrations <10 ng/mL and ≥10 ng/mL were similar in terms of age at oocyte pick up, IVF indications, serum LH concentration on the day of LH surge, serum progesterone concentration on the day of LH surge, endometrial thickness on the day of embryo transfer and number of embryos transferred. (The characteristics of patients.Values are expressed as mean± standard deviation for continuous variables and (n. (%)) for categorical variables. Of all transfers, 55.2% (100/181) of all transfers resulted in a clinical pregnancy. There was no significant difference between the groups regarding positive pregnancy test, OPR, multiple pregnancies, and miscarriage rates (57.8% versus 52.7%; 34.4% versus 29.7%, 1.1% versus 2.2%; 7.8% versus 5.5%; respectively, for progesterone concentrations on ET day ≥10 ng/mL and <10 ng/mL). Biochemical pregnancy rates (3.3% versus 12.1%, P = 0.02) was lower and clinical pregnancy rates (54.4% versus 40.7%, P = 0.03) was higher in patients with ≥10 ng/mL P concentrations on the day of ET. Serum progesterone concentrations on ET day were evaluated by percentiles (<10%, 10–49%, 50–90%, and >90%). The threshold for <10%, 10– 49%, 50–90%, and >90% were 0–5.9 (11%), 5,9–9,96 (39.2%), 9.96–16.54 (39.8%) and >16.64 ng/mL (9.9%), respectively. However, the positive pregnancy test of serum progesterone percentiles on ET day was 8% in the <10% percentile, 40% in the 10–49% percentile, 39% in the 50–90% percentile, and 13% in the >90% percentile. The CPR of serum progesterone percentiles on ET day was 5.8% in the <10% percentile, 37.2% in the 10–49% percentile, 43% in the 50–90% percentile, and 14% in the >90% percentile. There was no significant difference between the patients in terms of CPR in all percentiles when evaluating separately according to the day of embryo transfer. The CPR of serum progesterone percentiles for day three embrio on ET day was 35.3% in the <10% percentile, 41.2% in the 10–49% percentile, 17.6% in the 50–90% percentile, and 5.9% in the >90% percentile (P=0.41). The CPR of serum progesterone percentiles for blastocyst stages on ET day was 9.4% in the <10% percentile, 37.5% in the 10–49% percentile, 46.9% in the 50–90% percentile, and 6.3% in the >90% percentile (P=0.14). 10 ng/mL was represented as the threshold of the 51st percentile in this study. A total of 78.5% of biochemical pregnancies were under the 50 percentile.