Introduction
CAD, death
CORONARY ARTERY DISEASE, CAD, DELETION
Coronary artery disease (CAD) is a leading cause of death worldwideImportantly, there is substantial inter-individual variability in the response to systematic exercise training, with training-induced improvements in VOA potentially decisive determinant of exercise capacity adaptability is the insertion (I) and deletion (D) polymorphism in the human angiotensin-converting enzyme (ACE) gene, which is located on chromosome 17 at heading 23 (17q23)Importantly, an effect of the ACE I/D polymorphism on VOGiven the potential link between the ACE genotype and exercise capacity trainability in patients with CAD, the present study was undertaken to determine whether the ACE I/D genotype affects the outcome of systematic supervised exercise training on exercise capacity in patients with CAD.