Taxa significantly associated with clinical improvements
T2D, T2DM
To explore the taxa associated with improvement in clinical efficacy, the differences between baseline and week 4 after intervention in FMT alone and FMT plus metformin groups were analyzed by Wilcoxon-rank sum test. A total of 7 phyla, 57 families, and 133 genera level were significantly (p < 0.05) different after intervention in FMT alone group, while the numbers were 10, 63 and 206 in the FMT plus metformin group (The commonly and significantly different species of between the FMT alone and FMT plus metformin groups.Microbial species significantly changed after intervention and their correlation with clinical indicators. Since improvement in HOMA-IR is urgent in treatment of T2D, we further explored the species by conducting correlation analysis between HOMAR-IR and the species significantly different either after FMT or FMT plus metformin, based on samples from T2DM patients at baseline and week 4 after intervention. The results showed that most of the significantly associated species were positively correlated with HOMA-IR (