Statistical analyses
death
REGRESSION, EVENTS, EVENT
Time for follow-up was defined as the time from randomization until the first event, death, or last observation (December 31, 2019). Median time for follow up was 30.2 years for living patients and 17.4 years for all patients. We examined crude cumulative incidence rates which is failure probabilities for a particular type of event, in the presence of other events, which may impede the event of interest to occur [Subhazard ratios (SHR) and the 95% confidence intervals (CI) were estimated based on Fine and Gray's proportional subhazards model. For each analysis, cause-specific hazards (HR) and 95% CI based on Cox regression model were also calculated, censoring for cases representing the competing events above. The HRs and SHRs were similar, and both are reported in the tables. Analyses were done by the intention-to-treat, and the tests were two-sided.A p value of 0.05 was considered to be statistically significant. The statistical analyses were performed using STATA/SE 13.1 [