Introduction
lung injury, ABI
PATHOPHYSIOLOGY
The optimal ventilator settings are still debated in patients with severe acute brain injury (ABI) admitted to the intensive care unit (ICU) [In patients with ABI, lower tidal volumes may improve outcomes [It is generally accepted that in patients with ABI, monitoring and treatment of the ICP as the only single cerebral parameter is of limited value [As a first step, recognizing the need to enrich the evidence behind the recommendations for ventilator management in ABI patients without lung injury, we hypothesized that LPV would not induce significant changes in neuromonitoring-derived variables in this setting, provided that the baseline ICP was less than 22 mmHg. Therefore, the aim was to conduct the brain vent study to investigate the effects of LPV on brain pathophysiology, determined by simultaneous monitoring of TPP, brain oxygenation and indices derived from ICP waveform analysis.
