Methods in analysis to handle protocol non-adherence and any statistical methods to handle missing data {20c}
For missing data, if less than 5% of the sample contains at least one missing data point, it will not be imputed. The analysis will be performed as a complete case analysis. If more than 5% of the sample contains at least one missing data point, there are two options. If a variable contains less than 20% of missing data, we perform multiple imputation by chained equations (MICE). If a variable contains more than 20% missing data, it cannot be introduced in a statistical model.