Primary outcome
delirium, DSM-5-confirmed delirium, hemiparesis and decreased attention, Delirium, DSM-5, infarction
SUBDURAL HAEMATOMA, DISORDERS, DISEASE, COMPLICATION, REGRESSION, INFARCTION
In the music group, adherence to the music intervention before, during, and directly after surgery was 96%, 100%, and 74%, respectively (
A high DOSS score (ie, 3 or higher) was observed in 32 patients. This was caused by a neurosurgical complication, as confirmed on radiology, in three patients: two patients with infarction after a vascular procedure with hemiparesis and decreased attention. The other patient had a subdural haematoma which was evacuated in the operating room. This resulted in 29 patients with possible delirium by DOSS; 21 were evaluated by the psychiatrist who diagnosed delirium in 11 patients (57%, 
According to the DOSS, a significantly higher incidence of delirium was observed in the control (n=21) versus music (n=11) group in the ITT population for the univariable (22.3% vs 11.6%, p=0.048) and multivariable (OR/95% CI: 0.49/0.20 to 1.00, p=0.050) analyses. This was not observed in the mITT (p=0.064) and the safety (p=0.064) population. The occurrence of a DSM-5-confirmed delirium was not statistically significant between the control (n=7) versus music (n=4) group in the ITT (7.4% vs 4.2%, OR=0.55), the mITT (7.5% vs 4.4%, OR=0.57) and the safety (7.4% vs 4.3%, OR=0.58) population (Primary outcome*P values assessed with the Χ†Logistic regression analysis with groups, type disease and gender as independent variables.DOSS, Delirium Observation Screening Scale; DSM-5, latest Diagnostic and Statistical Manual of Mental Disorders.Of those patients with DSM-5-confirmed delirium (n=11), severity of delirium (mean/SD) was 12.60/5.52, which was not different between the two arms (p=0.857). The duration of delirium (days, mean/SD) was 3.36/4.69, which was not different between the two arms (p=0.761).