Introduction
hemorrhagic shock, PROPPR, trauma
HEMORRHAGIC SHOCK
Evidence-based medical practices remain the goal for clinical decision-making purposes in health care.Limitations in study design and methods pose further restrictions on a study’s quality and outcomes. Most medical studies are currently structured on frequentist statistics. Frequentist approaches often focus on the concept of providing evidence against a null hypothesis to highlight significant differences between various groups through the use of Bayesian statistics offer an alternative framework for data interpretation that provides the probability of a hypothesized treatment effect based on the known available data. Furthermore, bayesian approaches can preemptively incorporate prior knowledge (termed Considering these 2 statistical methods, this analysis incorporates both approaches to assess the landmark clinical trial: the Pragmatic Randomized Optimal Platelet and Plasma Ratios (PROPPR) Trial. The PROPPR Trial was the first prospective RCT to assess the resuscitation ratios of transfused units of plasma (FFP), platelets (PLT), and red blood cells (RBCs) for trauma patients in hemorrhagic shock by comparing a balanced (ie, 1 FFP:1 PLT:1 RBC; ie, 1:1:1) vs an RBC-heavy (ie, 1 FFP:1 PLT:2 RBC; ie, 1:1:2) transfusion strategy.