Definition of disease assessments
lymphadenopathy, hematologic/lymphomatous disorder, prostate, protocolRegional failure, regional failure
METASTASIS, LYMPHADENOPATHY, PROSTATE, PROGRESSION, METASTASES

Biochemical failure: two definitions of biochemical failure will be assessed:◦ Primary: PSA ≥ 0.4 ng/mL and rising or initiation of salvage hormones◦ Alternate: PSA ≥ PSA nadir + 2 ng/mL where nadir is the lowest post-RT PSA levelLocal failure: development of a new biopsy-proven mass in the prostate bed, after enrollment in the protocolRegional failure: radiographic evidence (CT or MRI) of lymphadenopathy within the pelvis (lymph node size ≥ 1.5 cm in the short axis) in a patient without the diagnosis of a hematologic/lymphomatous disorder associated with adenopathyDistant metastases: radiographic evidence of hematogenous spread (Progression: first occurrence of biochemical failure, local failure, regional failure, distant metastasis, initiation of salvage ADT