Ethical approval
The study protocol of the OPTICA trial and other documentation was approved by the competent ethics committee of the canton of Bern (KEK), Switzerland, and the Swiss regulatory authority (Swissmedic) (BASEC ID: 2018–00914). The KEK and Swissmedic received annually safety reports and were informed about the end of the study. The OPTICA trial was performed in accordance with relevant regulations and guidelines. General practitioners and the study team obtained written informed consent from all participants or their legal representatives before study enrolment.