Discussion
sepsis
SEPSIS
To the best of our knowledge, this study is the first RCT to evaluate the difference in cytokine CHA between the AN69ST and PMMA hemofilters in a clinical setting. We found that AN69ST and PMMA membranes had significantly different cytokine CHA in patients with sepsis in different time points at 2–4 h and 12–24 h after CRRT initiation (Table The AN69 membrane is an electronegative copolymer of acrylonitrile and sodium methanesulfonate. AN69 can undergo adsorption in the membrane bulk through electrostatic interaction. In contrast, AN69ST was achieved by neutralizing the surface in contact with blood by ionic grafting of a polycationic polymer in AN69; however, AN69ST can also be adsorbed in the membrane bulk through electrostatic interaction [An in vitro closed-loop circulation system study showed that time-dependent changes of transmembrane pressure (TMP) were not observed but time-dependent superiority for CHA ability was observed in AN69ST membrane in comparison with PMMA for HMGB1 [In contrast, PMMA membranes have a higher CHA ability for IL-6 than for AN69ST membranes (Table Cytokine levels were significantly decreased in both the AN69ST and PMMA groups (Fig. Some observational studies [