Statistical Methods
stroke
STROKE
Statistical analyses were performed using Matlab R2020 software. For measures
taken at baseline and follow-up, the change from baseline to follow-up was
calculated. Then the changes were compared between groups using an unpaired
two-tailed MAS scores were grouped by flexion or extension items and summed to obtain lumped
MAS extension and flexion values. We quantified items marked with a “+,” with an
additional 0.5 points for calculations. EQ-5D-L3 was analyzed
following.Several participants dropped out of the study (see Participant flow diagram. Subjects who did not return for an
end-of-therapy assessment were not considered for analysis. Missing data
was imputed as described in the statistical methods to maintain group
sizes across all analyses.To assess the ability of FitMi to motivate an appropriately high dose of home
therapy, we performed a post-hoc exploratory analysis comparing the total number
of repetitions that FitMi participants completed to a theoretical target dose of
2700 repetitions. A dose of 2700 repetitions of UE exercise corresponds to
300 repetitions/hour (5 reps/minute) over 9 hours of exercise, an intensity and
duration sufficient to provoke a forelimb rehabilitative effect in a rodent
model of stroke.