SYNERGIC Trial Consortium Flowchart
MCI, cognitive impairment
SECONDARY
MCI indicates mild cognitive impairment.Between-arms comparisons followed our protocol and statistical analysis plan, which aligns with the recommended analysis and reporting of factorial trials.The durability of the intervention effect from baseline and postintervention to follow-up (month 12) was assessed for primary and secondary outcomes using linear mixed models with all 3 time points.Adjustments for multi-arm comparisons were not made as the trial is intended to compare the intervention effect with the control rather than pairwise, and no adjustments for having 2 primary outcomes were executed.