MMP-9, NOX2, and TGF-β1 in late PCI group
tumor necrosis, TNF-α
CELL DAMAGE, ADHESION, TUMOR NECROSIS
Based on the guidelines, it is certain that STEMI patients with an onset < 12 h will be treated with primary PCI or fibrinolytic [Besides the results in the No Revas group already suggest the benefit of colchicine in reducing MMP-9, NOX2, and TGF-β1, the analysis in both late PCI groups is still not significant. If we compare the level of biomarkers in Fig. IRI initially mobilizes neutrophils via chemotaxis and endothelial adhesion, CD4 + T cells, and circulating platelets in the vascular space. Neutrophils induce the generation of tissue-damaging reactive oxygen species (ROS), tumor necrosis factor-alpha (TNF-α), and local inflammatory mediators [These processes lead to the formation of free radicals, which are unstable molecules that destabilize inorganic and organic substances and cause cell damage [