Patient Population
allergy, hypersensitivity
ALLERGY, HYPERSENSITIVITY
Inclusion criteria were Chinese patients between 18 and 65 years of age, with moderate (Grade 2) or severe (Grade 3) wrinkles of vertical glabellar lines at maximum frown at baseline per the ILA, a validated four-point photographic scale to assess the severity of glabellar lines (where 0 = no wrinkles and 3 = severe wrinkles), and the subject’s self-assessment scale (SSA; a four-point categorical scale to assess the severity of glabellar lines, where 0 = no wrinkles and 3 = severe wrinkles). All patients were BoNT-A-naïve or had received their most recent BoNT-A treatment in any muscle of the face  > 1 year before screening. Exclusion criteria included any previous or planned treatments or surgeries that may have interfered with the evaluation of the study results and an inability to substantially lessen the glabellar lines by physically spreading them apart or a lack of capacity to frown. In addition, patients were ineligible if they had any current conditions (including facial conditions), were using any concomitant medications that could interfere with the safety, conduct, or outcomes of the study, or had a known allergy or hypersensitivity to BoNT-A or excipients. Female patients who were pregnant, lactating, or of childbearing potential but not willing to use contraception were also unable to participate.
