Statistical analysis
obesity, SD, ’
OBESITY
This economic evaluation was performed from a societal and a healthcare perspective, using a 12-month follow-up period. All participants included in the study were analyzed. Missing data were handled using Multivariate Imputation by Chained Equations (MICE) and the number of imputed datasets was determined using the loss of efficiency approach, where a loss of efficiency of <5% was deemed appropriate.In addition to the primary cost-effectiveness analysis, the following 5 a priori specified sensitivity analyses (SA) were performed. In SA1, the healthcare perspective was applied, meaning that only costs accruing to the formal Dutch healthcare system were included in the analyses. In SA2, the Human Capital ApproachClinical outcomes and knee-related health care utilization in OCTOPUS-trial.SD = standard deviation.based on data from patient-reported questionnaires after multiple imputation;.based on registration data from participating physical therapists and dieticians collected during study, without multiple imputation.only data from participants from ‘obesity subgroup’ in experimental arm (based on data from participants and/or therapists, without multiple imputation.