Gene set enrichment analysis of 
We performed rank‐based pathway enrichment analysis on the 16,450 protein coding genes using four major reference gene set collections, namely Hallmarks, Reactome, WikiPathways, and KEGG from the Molecular Signature Database MSigDB (v. 7.4; Subramanian et al., Selected significantly enriched pathways (Some differentially expressed genes and leading genes in the enriched functional pathways (Table 