Change From Baseline to End of Treatment (Week 24) in 6-Minute Walk Test: Subgroup Analysis by Genetic Abnormality
SE, −0.21
Subgroup analysis by genetic abnormality for change from baseline to end of treatment (week 24) in 6MWT for (A) participants with mtDNA alteration and (B) participants with nDNA alteration.nDNA: For participants with nDNA alteration (post hoc analysis), the LS mean (SE) change from baseline in distance walked at week 24 was 25.5 (±8.0) meters for participants receiving elamipretide (n = 29) and 0.3 (±7.7) meters for participants receiving placebo (n = 29), a 25.2-meter difference between the 2 groups favoring elamipretide (95% CI 3.1–47.3; For participants with mtDNA alteration, the LS mean (SE) of change from baseline at week 24 on the PMMSA TFS was −1.3 (±0.2424) for participants receiving elamipretide and −1.1 (±0.2525) for participants receiving placebo, a −0.21 difference between the 2 groups (95% CI −0.9 to 0.5; 