Identification of additional ICI response predictors by genomic analysis of pretreatment CUP metastasis tissue
MSI, tumor
TUMOR, MICROSATELLITE INSTABILITY
Panel sequencing data from baseline FFPE tumor biopsies were available for 29 of 31 patients. None of the samples showed microsatellite instability (MSI). Panel sequencing of 521 cancer-relevant genes revealed at least one molecular alteration in 28/29 CUP patients, including single nucleotide variants (SNVs) in 26 cases (89.7%) and CNAs, as revealed by sWGS, in 21 cases (72.4%) (Fig. 