Simulations
deaths, Tumor
REGRESSION, TUMOR
A simulation study was carried out to evaluate the impact of the proportion of MAR and MNAR deaths on the estimation of the parameters of mixed and joint models. In these simulations, we assumed a single group with a 28-day follow-up with several sample size of mice (300, 200, and 100). In addition, a proportion of all-cause deaths of 50% was assumed with the following MNAR and MAR distribution scenarios: 50% MNAR and 0% MAR, 40% MNAR and 10% MAR, 30% MNAR and 20% MAR, 20% MNAR and 30% MAR, 10% MNAR and 40% MAR, 0% MNAR and 40% MAR. For each scenario, 1,000 datasets were created. Tumor growth kinetics were simulated using a single slope mixed linear regression model with random intercept and slope. MNAR deaths were simulated using R programs provided by Thomadakis and colleagues (All simulations and analyses were carried out with the R software version 4.1.0 (R Project for Statistical Computing, RRID:SCR_001905).