Intervention adherence (tolerability)
fatigue, depression, Pain, shortness of breath
ADVERSE EVENTS
A total of 7 (21%) patients permanently discontinued aerobic training before week 24. Overall adherence to the supervised sessions was 83% (299 out of 360 possible sessions attended by participants). Patients attended on average 9.41 (SD 2.21) out of 12 supervised exercise sessions. Pain, shortness of breath, and conflicting medical appointments were the most common reasons given for missed exercise sessions. Participants were adherent to both the intensity (82%) and duration (83%) of the prescribed exercise programme during class sessions. A total of 21 (1%) supervised sessions, involving 9 (27%) patients, required early termination because of health-related non serious adverse events (e.g. excessive fatigue) or non-health-related reasons (e.g. difficulties with travel). No adverse events were reported by participants enrolled in this study. The combined correlation analysis for all three timepoints showed that adherence to supervised sessions was significantly correlated with quality of life, sleep score, depression, and sedentary behaviour; with the correlation being positive for quality of life and sedentary behaviour and negative for the other responses (Fig. Combined correlation analysis for supervised and home-based exercise programmes at three timepointsOverall adherence to the non-supervised home exercise sessions (months 1–3), measured by heart rate monitors, was 72%. Participants were equally adherent to both the intensity (74%) and duration (71%) aspects of the prescribed home exercise programme. During the three unsupervised months of the programme (months 3–6), overall adherence to the home exercise programme was 67% (exercise intensity, 69%; duration, 65%). Exercise adherence levels in the intervention group did not correlate with patient-reported outcomes at month 3 or month 6. The combined correlation analysis for all three timepoints showed that adherence to non-supervised sessions was significantly correlated with quality of life, stress, sleep score, and depression; with the correlation being positive for quality of life and negative for stress, sleep score, and depression (Fig. 