Immunogenicity
All 40 participants were followed-up at 5 time points to assess immunogenicity: 0, 15, 29, 57 and 85 days after administration. One participant (2.5%) in the 50 mg/kg dose group was found to have ADA prior to administration (day 0) and tested positive for antibody titers at day 85. The similar results have been reported in other clinical trials [