Study procedures and questionnaires
gastrointestinal symptoms, flatulence, diarrhea, burping, vomiting, constipation, colic
DIAPER DERMATITIS
After the study was properly explained, parents/caregivers were asked to sign the informed consent form. Subsequently, a screening visit took place in which anthropometric measurements were performed, and screening questionnaires were conducted to check the in- and exclusion criteria. Once enrolled in the study, the parents/caregivers received instructions on how to access and use the app which was used to fill in the questionnaires. Parents/caregivers were able to login with their individual account and see a listing of the task per day. They could open each of the questionnaires to insert the corresponding data. The app would prompt parents/caregivers to complete the required activities on a daily basis. Furthermore, stool sample kits were provided. To check the type of IF that was consumed, the parents/caregivers were requested to upload a picture of the IF used for feeding into the app as well.Parents/caregivers were requested to complete daily diaries, to record time and description of each bowel movement, according to the Amsterdam Infant Stool Scale [Parents/caregivers were also asked to rate certain gastrointestinal symptoms in the daily diaries (score per day absent = 0 – very severe = 5), including abdominal distension, burping, flatulence, diarrhea, constipation, colic, diaper dermatitis, arching of the back, vomiting, and spit ups/regurgitation.On day 7 parents/caregivers were requested to fill in the IGSQ (Infant Gastrointestinal Symptoms Questionnaire). The score was computed by summing the scores of all 13 items (range 13–65) [