Authors’ contributions
M.C.Lee, W.Y.Wu, W.H.Wu proposed concept development and design of study. H.Y.Lu, H.N.Hsieh performed statistical simulations and acquisition of data. M.C.Lee, W.Y.Wu, H.Y.Lu analyzed and interpreted data. H.N.Hsieh, W.H.Wu conducted manuscript drafting and revised the manuscript. All authors reviewed and approved the final manuscript.