Statistical analysis
The primary endpoint will be analyzed according to the intention-to-treat principle in patients who are randomized and receive preoperative treatments. Secondary analyses will be conducted using the per-protocol principle, considering only patients with sufficient compliance with the protocol. The Kaplan–Meier curve will be used to analyze the survival outcomes and the log-rank test for the prognostic factors. The chi-squared test will be employed to compare categorical data between the two groups and Student’s 