Epilepsy
seizure, Seizure, epilepsy
CLONIC SEIZURE, EPILEPSY
Twenty-eight of 64 patients (44%) were treated with everolimus for epilepsy as the primary indication (epilepsy indication group). Further, 17 (27%) had epilepsy but were primarily treated with everolimus for other indications (other indication group). Thus, in total, there were 45 patients in the entire epilepsy group (70% of the study’s patient sample).Seizure frequency per month at the start of treatment was higher in patients treated for epilepsy indication (mean/median: 32/28, SD: 36.6, range 0.25–175) than in patients treated for other indications (mean/median: 3.2/1.5, SD 4.12, range 0–14), and there were more patients with ≥ 3 seizure types (43 vs. 24%) and ≥ 3 ASMs (50 vs. 35%) at the start of treatment among patients treated for epilepsy than in patients treated for other indications. At least 50% seizure reduction occurred in 31% of the entire epilepsy group and was quite similar in both groups (Table Seizure reduction (≥ /< 50%) and related factors*Significant differenceThe proportions of patients with ≥ 50% (Table Figure Change in seizure frequency in patients with epilepsy (n = 45). *Clinically relevant reduction without a given percentage (when percentage change was not available)Forty-four (98%) had exact information about the number of ASMs during treatment. The number of ASMs decreased from baseline in 6 patients, increased in 10 patients in the entire epilepsy group, decreased in 5 patients, and increased in 6 patients in the epilepsy indication group. In the patients with ≥ 50% reduction in seizure frequency, one started vagus stimulation treatment, one changed the vagus stimulator, and one had epilepsy surgery during the treatment period.Seizure reduction was associated with younger age. The proportions of patients with ≥ 50%, ≥ 30%, and any seizure reduction were significantly higher in patients < 18 years of age in the entire epilepsy group (Table Seizure reduction was not associated with the number of seizure types, focal to bilateral tonic clonic seizure, seizure frequency, number of ASMs, or major changes in the use of ASMs (Table 