Non-inferiority trials
SECONDARY
The choice of population-level summary measure is particularly important in non-inferiority trials. In such trials, the non-inferiority margin has to be chosen, and this is expressed as a value of the population-level summary measure of treatment effect that would be considered non-tolerable even in the presence of secondary advantages of the research treatment.The choice of summary measure is more important than in superiority trials because different measures imply different null hypothesesDespite this issue, it is possible to match margins between different summary measures by using the expected values, though the null hypotheses remain different.