Cumulative incidence of death from possible (blue), probable (red) and proven (green) invasive fungal disease (IFD) in children treated for acute lymphoblastic leukemia.
proven/probable
MINIMAL RESIDUAL DISEASE
The In the multivariate analysis, the hazard ratio [95% confidence interval (CI)] for 5-year EFS was significant for proven/probable IFD (1.86, 1.42-2.45), age ≥12 years (1.14, 1.07–1.21), insufficient response to therapy [blast count on day 15 measured by flow- cytometry ≥10% (1.52, 1.26–1.82) or minimal residual disease measured by PCR on day 33 (2.08, 1.76–2.45); 