Conclusions
AKI, sepsis, CR-GNB
SEPSIS
For patients with sepsis caused by CR-GNB, a fixed polymyxin B loading dose of 150 mg followed by a maintenance dose of 75 mg every 12 h was safe, with better 180-day survival compared to patients receiving a lower dose. The target AUC compliance of polymyxin B was not correlated with clinical outcomes, but increased AUC was associated with increased incidence of AKI. Therefore, the TDM should be valued to prevent AKI in sepsis patients.