Ethical approval
This single-blinded RCT was approved by the Chinese Ethics Committee of Registering Clinical Trials (Approval No. ChiECRCT-20190011), and the study was registered in the Chinese Clinical Trial Registry Center (Registration No. ChiCTR1900022110). The study was conducted according to the Quality Management Practice for Drug Clinical Trials [Good Clinical Practice (GCP)] and the guidelines of the 1975 Declaration of Helsinki for human experimentation. Informed consent was obtained from each participant.