ACKNOWLEDGMENTS
WS, CM, Cancer
ONCOLOGY, EMD, CANCER
The authors would like to acknowledge the work and support from the following Biostatistics and Biospecimen Repository and Histopathology service shared resources of the Rutgers Cancer Institute of New Jersey.
Study conception and design: JM; Accrued patients to clinical trial: JA, MNS, JM, NC, AW, JM, KS; Data collection: KR, DP, JM; Pharmacokinetic and pharmacodynamic analysis and interpretation: KS, SG, SG, MG, HL, JL, RC, CM, SZ; Biostatistics support: WS; Analysis and interpretation of results: all authors; Draft manuscript and preparation: KS, DP. All authors reviewed, edited, and approved the final version of the manuscript.
KS is on the advisory board for QED Therapeutics. JA serves on the DMC for Merck-Serono. MNS reports consulting for Exelis, Merck Sharpe and Dohme, and Xencor; reports receiving research funding from Advaxis, Bristol Myers Squibb, Exelixis, Genocea Biosciences, Harpoon, Janssen Oncology, Lilly, Medivation/Astellas, Merck Sharp and Dohme, Nektar, Oncoceutics, Seattle Genetics, Suzhou Kintor Pharmaceuticals, Tumunity Therapeutics, and Xencor. JM serves on the advisory board for Astra Zeneca and receives research funding from Biohaven, Bristol Myers Squibb, Celldex, and Beyond Spring. SG has consulted for Merck, Roche, Foundation Medicine, Novartis, Foghorn Therapeutics, EQRX and Inspirataa and serves on the Scientific Advisory Board SilaGene and KayoThera and has equity in SilaGene; his spouse is an employee of Merck and has equity in Merck. SG receives salary from Johnson and Johnson. AWS receives research funding (to the institution) from Biohaven Pharmaceuticals and has served on advisory boards for Bristol-Meyers Squibb, EMD Serono, Merck, and Sanofi Genzyme. JMM has received honoraria from EMD Serono and Pfizer, reports serving as a consultant or advisor for Amgen and Merck Sharp and Dohme, reports serving on the advisory board for Array BioPharma, Bristol Myers-Squibb, EMD Serono, and Sanofi/Regeneron; and has received grants from Amgen, AstraZeneca, Bristol-Myers Squibb, Merck Sharp and Dohme, Novartis, Polynoma, Sanofi, EMD Serono, Immunocore, Incyte, and Macrogenics. The remaining authors report no conflicts of interest or disclosures.
The research was conducted in accordance with the principles embodied in the Declaration of Helsinki and in accordance with local statutory requirements. All participants provided written informed consent to participate in the study.
This trial received funding from both the Cancer Therapy Evaluation Program (CTEP) [NCT01303341; NCI Protocol #8850] and the National Institute of Health grant 1R01CA149627-01 and the National Cancer Institute Cancer Center Support Grant (P30CA072720).