Research design
congenital heart disease, congenital malformations, gastrointestinal abnormalities, intestinal obstruction
SKIN DISEASE, PREMATURE, COMPLICATIONS, INTESTINAL OBSTRUCTION
This study was a prospective randomized controlled study conducted in the Department of Neonatology in a hospital on the southeast coast of China from June 2019 to October 2020. Based on the difference in the incidence of feeding intolerance (13% vs 35%) between the two groups from the pre-experiment, and assuming that the alpha value was set at 0.05 with a power of 0.80, the required number of participants was calculated to be 45 in each group. Assuming a 10% rate of missing data, the total sample size was set at 100 (50 per group). A total of 100 Premature infants were enrolled in this study.The inclusion criteria were as follows: 1) preterm infants who received enteral feeding, 2) a gestational age of 28-36 weeks, 3) vital sign stationarity, 4) no intestinal obstruction or abdominal surgery, 5) no skin disease, and 6) parents' informed consent. The exclusion criteria were as follows: 1) unstable medical condition; 2) complications of severe congenital malformations, such as severe congenital heart disease and gastrointestinal abnormalities, etc.; and 3) weight<1000 g.\