ICSI outcomes by sex preference.
congenital malformations
MINOR, PREGNANCY LOSS
+FHB: Presence of at least one fetal heartbeat.ICSI/PGTA couples underwent 2,303 cycles, in which an average of 7.7 oocytes were injected, yielding an 81.0% (14,375/17,737) fertilization rate. In addition, 45.3% (n = 599) of their embryos were female, and 54.7% (n = 724) were male. Following embryo replacement, these couples achieved a 76.4% (699/915) implantation rate and a 65.2% (597/915) clinical pregnancy rate, resulting in 551 deliveries (48.5% female, 51.5% male) and 46 incidences of pregnancy loss.The 59 couples who wanted female offspring were treated in 73 ICSI cycles and obtained a 77.3% (583/754) fertilization rate. Overall, 79.1% (231/292) of the tested embryos were female. These couples achieved a 79.3% (23/29) implantation rate and a 62.1% (18/29) clinical pregnancy rate, which yielded 16 singleton deliveries of the desired female sex without major or minor congenital malformations.The 46 couples desiring male offspring were treated in 50 ICSI cycles, which yielded a 75.4% (462/613) fertilization rate and a 79.6% (223/280) proportion of male embryos. They achieved a 90.5% (19/21) implantation rate and a 66.7% (14/21) clinical pregnancy rate, yielding 13 singleton deliveries of healthy baby boys. All children have been faring well, with no developmental delays at 3 years of age. Overall, there were no significant differences among the cohorts in terms of fertilization, implantation, or clinical pregnancy rates.To further address safety concerns with the use of this sex selection method, we studied the ploidy of the tested embryos of the control (ICSI/PGTA) and study (ICSI/PGTA+GS) groups (