Background
gastrointestinal events, pulmonary fibrosis, ILD, fibrosing, fibrosing ILD, fibrosing interstitial lung disease, fibrosis, IPF, weight loss
ADVERSE EVENT, PULMONARY FIBROSIS, FIBROSIS, IDIOPATHIC PULMONARY FIBROSIS
Patients with various forms of fibrosing interstitial lung disease (ILD) may develop progressive fibrosing ILD, more recently termed progressive pulmonary fibrosis (PPF), characterized by decline in lung function, increasing fibrosis on radiology, worsening symptoms and quality of life, and high mortality [Many patients with pulmonary fibrosis experience weight loss [The randomized placebo-controlled INBUILD trial of nintedanib was conducted in subjects with progressive fibrosing ILDs other than idiopathic pulmonary fibrosis (IPF). The results showed that nintedanib slowed decline in lung function, with an adverse event profile characterized mainly by gastrointestinal events [