Exploratory metabolic data
DISEASE
A total of 30 patients out of 46 underwent a metabolic assessment. At the baseline evaluation, the median highest SUVmax was 12.0 (IQR 7.0-15.7), the median total SUVmax was 21.4 (IQR 12.5-33.3), and the median highest TLG was 39.5 (IQR 5.7-110.2) (After 2 weeks of treatment, three patients (10.0%) had a metabolic response according to the highest SUVmax, five (16.7%) according to total SUVmax and four (13.3%) according to the highest TLG. The early metabolic response was not associated with clinical outcomes (Baseline metabolic assessment was not associated with PFS (Conversely, baseline metabolic evaluation, assessed with the highest SUVmax and total SUVmax, was associated with OS. As per univariate analysis, carried out in the group of 30 patients undergoing metabolic assessment, a numerical increased value of baseline highest SUVmax (HR 1.10, 95% CI 1.03-1.17, Moreover, in a multivariate model including the number of metastatic sites, the presence of lung-limited disease, and total SUVmax, the only covariate significantly associated with survival was baseline metabolic evaluation as total SUVmax (HR 1.03, 95% CI 1.01-1.05, 