RESULTS
vascular occlusion
DILATION, VASCULAR OCCLUSION, REACTIVE HYPEREMIA
Participant screening characteristics and blood chemistries for the 27 participants who completed this study are presented in Table Screening characteristics.Abbreviations: BMI, body mass index; BP, blood pressure; BUN, blood urea nitrogen; eGFR, estimated glomerular filtration rate; HDL, high‐density lipoprotein; LDL, low‐density lipoprotein; MAP, mean arterial pressure; VLDL, very‐low‐density lipoprotein.

Table Participant characteristics on Day 10 of each intervention.Abbreviations: BP, blood pressure; HDL, high‐density lipoprotein; HSD + MEL, high sodium diet plus melatonin; HSD + PL, high sodium plus placebo (lactose); LDL, low‐density lipoprotein; MAP, mean arterial pressure; VLDL, very‐low‐density lipoprotein.



Vascular function results collected on Day 10 of each condition are presented in Table Vascular function on Day 10 of each condition.Abbreviations: AUC, area under the curve; FMD, flow‐mediated dilation; HSD + MEL, high sodium diet plus melatonin; HSD + PL, high sodium diet plus placebo (lactose); NIRS‐VOT, near‐infrared spectroscopy with vascular occlusion test; TSI, tissue oxygenation index; TSI

Macrovascular function assessed via brachial artery flow‐mediated dilation (FMD) at the end of the high sodium diet plus placebo condition (HSD + PL) and at the end of the high sodium diet plus melatonin condition (HSD + MEL). (a) Relative FMD; (b) Shear rate area under the curve (AUC) to peak reached during reactive hyperemia. Microvascular function assessed via near‐infrared spectroscopy during vascular occlusion test (NIRS‐VOT) at the end of the high sodium diet plus placebo condition (HSD + PL) and at the end of the high sodium diet plus melatonin condition (HSD + MEL). (a), Slope 2, also known as reperfusion slope; (b) Tissue saturation index area under the curve (TSI AUC). ROS were measured as a potential mechanism by which melatonin may exert its antioxidant effects. We found no difference in superoxide between conditions as assessed by nitroxide molarity and free radical number as depicted in Figure Reactive oxygen species (ROS) at the end of the high sodium diet plus placebo condition (HSD + PL) and the high sodium diet plus melatonin condition (HSD + MEL). (a) Nitroxide concentration; (b) total number of free radicals. 