Pharmacokinetics
The trough concentrations of filapixant determined on the morning of the 4th day of treatment with filapixant 20, 80, 150, and 250 mg BID increased in an approximately dose proportional manner from 14.7 µg/L [87.5%], 70.5 µg/L [42.1%], and 109 µg/L [156%] to 198 µg/L [210%] (geometric means and coefficients of variation). (For post-dose concentration–time curves, see Additional file 