Bedside Goal-Directed Checklist to Guide the Care of Brain-Dead Potential Donors
stroke, cardiac arrest
STROKE, CARDIAC ARREST
ΔPp indicates pulse pressure respiratory variation; ΔSV, stroke volume respiratory variation; CVP, central venous pressure; FiOThe checklist was designed to maximize the conversion of potential to actual organ donors by preventing the loss of brain-dead potential donors to cardiac arrest and to increase organ viability. It consists of 13 goals and 14 actions, including mechanical ventilation, vasoactive support, hormonal supplementation, electrolyte control, body temperature control, and administration of antibiotics and blood products (Expert clinicians visited all sites randomized to the intervention group to provide standardized 4-hour training sessions to the ICU and in-hospital donation and transplant coordination staff. The content of these sessions included world and national scenarios of organ donation, recommendations from the evidence-based clinical practice guideline, and the composition and administration of the paper-based bedside checklist.Based on studies that analyzed the effect of meeting physiological goals on referral after 6 hoursFor patients in the control group, usual care was provided. We instructed the ICU and in-hospital donation and transplant coordination staff at control sites to maintain routine care without sharing information about the checklist.For both study groups, a family interview was conducted. The staff were trained, through an online course and a face-to-face course, to prepare for this task according to the standardized Spanish model of family interview regarding organ transplant (eTable 2 in 