Introduction
prediabetes, hypoglycemic, Diabetes, weight loss, diabetes
DIABETES, TYPE 2 DIABETES, PREDIABETES, DIABETES
Diabetes continues to be a major global health concern with a rapidly rising incidence. The incidence of conversion of prediabetes to diabetes has increased greatly. According to the International Diabetes Federation (IDF), 382 million people globally (8.3% of adults) are affected by diabetes, and the incidence is predicted to increase beyond 592 million in the next 25 years [There is a lack of robust recommendations to prevent or delay the progression of prediabetes to type 2 diabetes because of limited pharmacological options and scarce literature on nutraceutical therapy with favorable safety profiles. ADA recommends lifestyle behavior changes to prevent the progression of prediabetes to diabetes, including weight loss, moderate-intensity physical exercise, dietary changes, and metformin pharmacotherapy [Berberine is a naturally found alkaloid with a quaternary-based chemical structure that is known to have a hypoglycemic effect. It has been used in Ayurveda in India, traditional Chinese medicine, and Middle Eastern countries for over 400 years [