Discussion
wheezing, asthma, wheeze
ASTHMA
In this study protocol we described the assessment of the three main objectives of the ADEM2 study: with respect to the first objective, a multicentre RCT will be performed to assess the potential gain in health and reduction of health care related costs by means of a proper early diagnosis through the breath test in wheezing preschool children. Parallel to the RCT, a longitudinal observational cohort study will be executed to unravel early and important pathogenic mechanisms of asthma and transient wheeze (second objective), and to assess the diagnostic potential of alternative VOCs sensing techniques besides GC-tof–MS as well as other multi-omics measurements (third objective).