Author contribution
Marco Annunziata and Giovanna Donnarumma equally contributed to study design, data acquisition and interpretation, manuscript drafting and revision and share the first authorship. Agostino Guida contributed to data analysis and interpretation, manuscript drafting and revision. Livia Nastri contributed to data acquisition and to manuscript drafting and revision. Gerardo Persico contributed to data acquisition and to manuscript drafting. Alessandra Fusco contributed to data acquisition and to manuscript drafting. Ignacio Sanz-Sánchez and Luigi Guida equally contributed to study conception, design and supervision, data interpretation, manuscript drafting and revision and share the last authorship. All authors gave their final approval and agreed to be accountable for all aspects of the work.