Brain activity
cognitive reappraisal, OLP
CORTEX
Region-of-interest analyses: The group comparisons for the contrast Disgust > Neutral indicated that both cognitive reappraisal (CR) and the open-label placebo (OLP) were associated with increased activity in the ventrolateral prefrontal cortex (VLPFC) relative to the passive viewing (PV) of the disgust pictures (corresponding Brodmann areas were BA 47 for the contrast CR-PV and BA 45 for the contrast OLP-PV). CR decreased activity in the putamen, pallidum, and anterior insula compared to PV. The direct comparison of OLP with CR indicated greater activity in the putamen and pallidum for the placebo group (see Fig. Differences in activation between (Group comparison of brain activity (contrast: disgust > neutral).