
Duration of PLT-R

thrombocytopenia
THROMBOCYTOPENIA
At the time of data cutoff, 16 of 47 (34.0%) responsive patients in the eltrombopag arm are still responsive on treatment versus one of six (16.6%) responsive placebo patients. Median duration of response in the whole group was not reached during the entire observation period. In the eltrombopag arm (observation period of 13-561 weeks), 12 of 47 (25.5%) of eltrombopag subjects lost the PLT-R with a cumulative thrombocytopenia relapse-free survival at 60 months of 63.6% (95% CI, 46.0 to 81.2; Data Supplement [Fig S2]). Among 12 patients who lost PLT-R, one patient recovered a response by increasing eltrombopag from 100 mg to 200 mg. The remaining 19 eltrombopag responders terminated the study still in PLT-R for various reasons. No difference in PLT-R duration was observed between responders of the active arm and those of the control arm (log-rank test = 2.16; In the placebo arm (observation period of 83-398 weeks), the six placebo responders maintained the PLT-R until study termination. One remains in the study after 76 months of response.Additional results on PLT-R and reasons for early study termination are provided in the Data Supplement.