Efficacy in the overall (ITT) populations
inferior corneal fluorescein, SE
For the overall population of patients with mild to severe DED, for inferior corneal fluorescein staining the PL9643 group showed better improvement than the placebo group, but did not demonstrate a statistically significant difference in mean change from baseline at week 12 compared to the placebo group (pre-CAE to post-CAE) with a PL9643 versus placebo least squares (LS) mean (95% CI) change of −0.11 (−0.38 to 0.16; Primary Efficacy Endpoints for the Intent-to-Treat Population95% CI, 95% confidence interval; LS, least squares; SE, standard error.