Conclusion
We confirmed that late lesion growth in the subacute period (between 24-hours and 1 week) after treatment is common and is associated with poor outcome in the sub-acute period (between 24-hours and 1 week) after treatment. We did not find evidence that IVT with alteplase influences the growth of lesion characteristics. Lastly, IVT did not influence the association between late lesion growth and outcome, suggesting that developing treatments to cease the lesion development are crucial.