Strength and limitations
We consider the main strength of this study showing another research perspective for the VLCHF and HIIT issue which can contribute to a better understanding the effects of such a diet with and without exercise. The lipidomic and metabolomic results complement the performance, body composition and biochemical data which have been already presented elsewhere (Cipryan et al., The limitations of the study design have been discussed previously (Cipryan et al., We have demonstrated the metabolomic and lipidomic differences between the VLCHF and VLCHF + HIIT groups versus HIIT and control groups along with a significant total energy decrease in all intervention groups (except the control group) (Cipryan et al., 