Study population
Congenital anomalies, digestive system anomalies, RDS, cyanosis, congenital cyanotic heart diseases
CHROMOSOME ABNORMALITIES
This triple-blind randomized clinical trial study was performed on hospitalized neonates in neonatal intensive care unit (NICU) of Afzalipour hospital (Kerman, Iran) between April 1, 2020 and February 1, 2021. Diagnosis of RDS, gestational age of 28–34 weeks and weight ≥ 1 kg were considered as inclusion criteria. Congenital anomalies such as congenital cyanotic heart diseases, digestive system anomalies and chromosome abnormalities were the exclusion criteria.RDS diagnosis and its severity was conducted based on classic clinical presentation of RDS includes grunting respirations, retractions, nasal flaring, cyanosis, and increased oxygen requirement, together with diagnostic finding and onset of symptoms shortly after birth [