Sample size {14}
pain
BONE METASTASES
Four weeks after the start of treatment, patients in the control group may just have received radiotherapy or still need to undergo radiotherapy. Therefore, we assume that they do not experience a pain response yet at that time point. From the PRESENT cohort, we know that patients who did not experience a pain response after radiotherapy had a physical functioning mean score of 43.6, 4 weeks after the start of radiotherapy.A recent study reported a minimal clinically important difference (MCID) of 13 points on the EORTC QLQ-C15-PAL physical functioning scale in patients with bone metastases undergoing radiotherapy [