Discussion
low RFMI, diabetes disability, death, muscle mass, neuropathy, lower limb muscle, sarcopenia, axonal degeneration of sensory/motor nerves, T2DM, demyelination, diabetes
NEUROPATHY, ANDERSEN, SARCOPENIA, REGRESSION, DEMYELINATION, DIABETES
In this study, low RFMI was found to be associated with DPN in T2DM patients, corroborating previous reports. Henning Andersen and colleagues showed that diabetics have decreased lower limb muscle volume, which has a tight association with the degree of neuropathy (Additionally, both the amplitude and CV of sensory/motor nerves declined with decreasing RFMI. Furthermore, RFMI and NCS indexes were positively correlated. These results showed that both demyelination and axonal degeneration of sensory/motor nerves are tightly correlated with sarcopenia in diabetics. Giorgio Orlando and colleagues showed that DPN affects the muscle by impairing motor nerve conduction (Besides RFMI, risk factors for DPN also encompass diabetes duration based on logistic regression, consistent with previous findings (DPN incidence is elevated in diabetics, also representing a major cause of diabetes disability and even death (In this study, ultrasound was utilized to evaluate muscle mass as a simple, non-radiative and highly operable tool, which can be easily applied in clinical and large-scale studies. Nevertheless, this study had some limitations. First, with a cross-sectional design, a causal relationship between RFMI and DPN could not be determined. Secondly, physical activity, which may be associated with muscle mass, was not assessed.