Ethics approval and consent to participate
This study was conducted in full accordance with all applicable research policies, and all methods were carried out in accordance with relevant guidelines and regulations.The study was performed following the protocol that the National and Kapodistrian Athens University Medical School, Ethics and licensing committee approved.All patients sign an informed consent form, before being included in the research groups for participating and publishing the data. The consent form was reviewed and approved from the ethic committee of the hospital.