Statistical considerations and analysis
The number of participants in the study was determined using the online application BiostaTGV with an error α of 5% and a power (1-β) of 80%, and an expected difference of diagnostic yield of 30%. According to the D’Agostino & Pearson test used to challenge the normality of the distributions; comparisons between two groups were tested by unpaired Student t tests or Mann–Whitney tests. Proportions were compared using the Chi