Conflict of interest
Author GL-R acts as a consultant for Icon Genetics GmbH (Halle, Germany) to assist in the design and management of the trial, analysis of results, and development of the manuscript. AD, FJ, VK, and FT are employees of Icon Genetics GmbH (Halle, Germany), a wholly owned subsidiary of Denka Company, Ltd. (Tokyo, Japan).The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.The authors declare that this trial has received funding from Icon Genetics GmbH (Halle, Germany), a wholly owned subsidiary of Denka Ltd. (Tokyo, Japan). The funder was involved in the study design, analysis and interpretation of data, the writing of this article, and the decision to submit it for publication.