Definition 1
toxicity
Given prespecified values Throughout the paper, we shall denote the MTD as Here, the variables The medical interpretations of the variables are as follows:Maximum toxicity level Homogeneity constant Dose range We detail some modeling considerations concerning the variables. The clinical meaning of the maximum toxicity level On the other hand, the homogeneity constant The dose range Pictorial illustration of determining an MTD from two different perspectives: continuous toxicity response (left panel) and binary toxicity response (right panel)Figure 