Patients and data extraction
death, cirrhosis, tumors
DISEASES, CIRRHOSIS, HEPATIC COMA, LIVER CIRRHOSIS, TUMORS
Patients enrolled in this study were hospitalized in the ICU and diagnosed with cirrhosis complicated with HE at discharge. The exclusion criteria were as follows: (1) Not hospitalized in the ICU or duration of hospitalization in the ICU ≤ 24 h, (2) The patient’s data completely lacked laboratory test records or had a range of values, (3) Wrong follow-up time, (4) Patients with tumors, (5) Age < 18 or > 89. The screening process is shown in Fig. The screening process of the study sample. MIMIC-III, Medical Information Mart for Intensive Care IIIThe relevant data of patients were extracted from the MIMIC-III database by executing the structured query language. According to the ninth edition of the International Classification of Diseases (ICD-9), the ICD-9 codes 0700,07020,07021,07022,07023,07041,07043,07044,07049,0706,07071,07042,5722, were used to extract information of patients diagnosed with HE (including hepatic coma). Then, ICD-9 codes 5712,5715,5716 were used to extract information about patients diagnosed with liver cirrhosis. If patients had records of multiple hospitalizations or admissions to the ICU, the first ICU records of each hospitalization were included in the study.The data extracted from the MIMIC-III database in this study included demographic factors, average vital signs on the first day in the ICU, urine output in the first 24 h of ICU, first laboratory examination results after admission, comorbidities, SOFA score, and MELD score. In addition, information about therapeutic measures during hospitalization was also extracted. Ninety days survival after discharge was used as the endpoint of this study. The survival time was based on the time from discharge to death recorded by the Social Security Administration.