Acknowledgements
The authors thank the Dongmei He’s research staff and patients who participated in the trial. The authors also thank Mr. Sicheng Wu and Mr. Xin Nie (Biostatistics Office of Clinical Research Center, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China) for help with statistical analysis. The trial is registered at chictr.org.cn, ChiCTR1900021821. Full details of the trial protocol are available at Chictr.org.cn.