Objective/Aims
The aim of the COOL trial is to test the null hypothesis that there will be no difference in survival when an OA management strategy administering NPPT is utilized compared to a primary fascial closure strategy in patients with SCIAS. The study is designed as a prospective, single-blinded, multicenter, international RCT. A SPIRIT Diagram overview of the trial is presented in Table SPRIT Diagram describing schedule of enrollment, interventions, and assessments1. Singer et al. [8]2. Sartelli et al. [9]3. Posadas-Calleja et al. [64]