Authors’ contributions
CH and J-PN These authors takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation. CH, J-PN, NG, AS, BB, KS, SJK, RG, EG, MK and UKK. These authors acquired the data, critically revised the manuscript for key intellectual content and approved the final manuscript. MK and UKK are the corresponding authors and contributed equally to the elaboration of the study protocol, they are principal investigators in Tyrol (Austria) and are EVA-Tyrol’s project directors. All authors read and approved the final manuscript.