Discussion
cataract, IOL, glaucoma-related AEs, blindness
CATARACT, SECONDARY, IOL, BLINDNESS
Pediatric cataract is the leading cause of avoidable childhood blindness worldwide. Treatment of pediatric cataract remains challenging because of the extremely high incidence of glaucoma-related AEs. Our prospective interventional case series have proved that compared to ciliary sulcus secondary IOL implantation, in-the-bag IOL implantation reduced AEs and yielded better IOL centration and VA for pediatric aphakia. Based on this research, we plan to conduct a multi-center RCT to further investigate the safety and efficacy of two approaches of IOL implantation in pediatric aphakia. The results will provide high-quality evidence for the clinical guidelines for the treatment of pediatric aphakia.