Study groups
Participants, physicians and house staff are blinded to the study group assignment. Participants undergo sequential randomization to one of 4 study groups:SPS (Kayexalate, Kionex) one dose of 30 gPatiromer (Veltassa) one dose of 25.2 gSodium zirconium cyclosilicate (Lokelma) one dose of 15 gPolyethylene glycol 3350 (MiraLax) one dose of 17 g (nonspecific osmotic laxative)Higher doses of the oral potassium binders were chosen to evaluate maximum impact on lowering blood K