2.1. Study Population
CRC
MAY, COMPLICATIONS
Retrospective analysis of 2279 patients of CRC with confirmed diagnosis at Wuhan Union Hospital from May 2017 to December 2019 was done. Patients with the following conditions were excluded from the study: (i) no MMR status outcome, (ii) no complete clinical data, and (iii) history of radiotherapy and chemotherapy prior to MMR status identification. A total of 2279 patients were enrolled in our study and randomly assigned to train and test sets in a 7-to-3 ratio. The consensus criteria for dMMR protein diagnosis were to select CRC patients who met the Revised Bethesda Guidelines (RBG) and then underwent MSI testing and/or immunohistochemical staining for MMR protein. This study was approved by the Ethics Committee of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (No. 2018-S377). All patients signed an informed consent form stating that they understood the procedure and its potential complications and agreed to participate in this study.