Data management and handling of missing data
Data will be managed and stored using REDCap, a secure software designed exclusively to support data capture for research studies. Considerable efforts (e.g., electronic data capture, standardized data checking strategies) will be made to limit missing data. Rates of missing data will be reported and addressed statistically if over 10%. If missing data are considered to be missing at random, multiple imputation or inverse probability weighting will be implemented at the time of final analysis. Given the modest sample size of this study, every effort will be made to minimize missing data.