Discussion
desaturation, anxiety, cerebral desaturation
Children in critical stages of development are particularly vulnerable. Surgical stress response, intraoperative blood transfusion, a decrease in rScONPOBC is associated with multiple risk factors, including young age, type of surgery, preoperative and induction anxiety in the preoperative periods, and method of inhalation anesthetic agent used [NPOBC has previously been associated with preoperative anxiety in children [Another independent risk factor for NPOBC on postoperative day 3 is the presence of cerebral desaturation (OR: 1.16, 95%CI: 1.02–1.32). There is no standardized, general absolute to define pathological brain region desaturation in children, perhaps partially attributable to the wide baseline variation of rScOOur nomogram included all three independent risk factors described above. To the best of our knowledge, this is the first study to build the nomogram with preoperative factors based on a prospective cohort of 192 patients and quantify the probability of NPONC individually. Parametric bootstrapping internally validated the established nomogram, which demonstrated good generalization and predictive performance. According to the calibration plot, the predicted and observed consequences were in agreement. ROC analysis revealed excellent discrimination between the nomogram and the NPOBC on postoperative day 3 (AUC = 0.762, 95%CI: 0.691—0.833). As the incidence of NPOBC in the early postoperative period reported in previous studies ranged from 24 to 80% [The prospective design of this study may exclude some confounding factors. However, it is important to note that our study has some limitations. First, PHBQ is designed for assessing children’s posthospitalization and postoperative new onset behavioral changes and has a good profile of reliability and validity [