Author contributions
R.E.M.
R.E.M. conceived and designed the study and led efforts in drafting the manuscript. R.E.M., M.D.F., B.L.L., E.-M.K.S., A.G. and M.E.P. acquired the data. R.E.M., J.A.G. and G.Z. analyzed the data. R.E.M., M.D.F., J.A.G., B.L.L., E.-M.K.S., A.G., S.P., D.Y., G.Z. and M.E.P. interpreted the data, contributed substantially to subsequent versions of the manuscript by critically revising it for important intellectual content and approved the final version of the manuscript for submission.