Design and setting
disability, Fatigue
MULTIPLE SCLEROSIS
The study was located at the Neurological Rehabilitation Center (NRC) Godeshoehe GmbH in Bonn, Germany, which provides neurorehabilitation for all levels of disability. It is certified by the German MS Society as one of three MS rehabilitation centers in the state of North Rhine-Westphalia and treats around 120 pwMS each year, 75% coming from within-state. All study-related sessions were implemented within existing therapy services of the NRC.The study had a two-armed, parallel-group, randomized-controlled design with 12 weeks follow-up (Fig. 
CONSORT diagram. EDSS=Expanded Disability Status Scale; FSMC=Fatigue Scale for Motor and Cognitive Functions; MAT=multimodal agility-based exercise training; MS=multiple sclerosis; SET=strength and endurance training; WEIMuS= Würzburg Fatigue Inventory for Multiple SclerosisEthical approval was obtained from the Ethics Committee of the University of Bonn (reference number: 543/20). The study was prospectively registered in the German Clinical Trials Register (ID: DRKS00023943) on 23rd September 2021. For more details we refer to the published feasibility protocol [