Composition of the coordinating center and trial steering committee {5d}
The coordinating center is the University of California, San Francisco. There are weekly meetings between the coordinating center principal investigator, project managers, and research fellows where any data quality or study-related issues are discussed. In addition, there are bi-monthly meetings with the study site principal investigator and research coordinators where study progress and issues are discussed. In addition, the trial is overseen by the trial steering committee, consisting of the statistician and two orthopedic surgeons from the coordinating center. The adjudication committee consisting of two orthopedic surgeons from the coordinating center and one Tanzanian orthopedic surgeon meet every 2 months to adjudicate any suspected cases of the primary outcome.Finally, the trial has additional external oversight by both the NIAMS-appointed monitoring body and the DSMC. An organization chart of all involved organizations can be seen in Fig. Study organization chart