Study population and case definition
SARS, infection
INFECTION
The study population consisted of any person age 18 years and above who received T/C at our institution between January 1, 2022 and July 31, 2022. To identify possible cases for inclusion in the study, we utilized the electronic medical records (EMR). Cohort members were considered to have had COVID-19 if they had a positive SARS CoV-2 test or if they had been prescribed one of the COVID-19 therapeutics (remdesivir (Veklury, Gilead), nirmatrelvir-ritonavir (Paxlovid, Pfizer), and neutralizing monoclonal antibodies (including REGEN-COV [casirivimab/imdevimab], (Regeneron); sotrovimab, (GlaxoSmithKline); and bebtelovimab, (Eli Lilly). For those patients with multiple positive tests, we performed a chart review to assess whether the repeat positive test was considered by clinical teams to have been consistent with a new infection.Although we identified all cases in our study population between October 1, 2021 and July 31, 2022, the current analysis focuses on cases who were confirmed on the basis of genotyping to have an Omicron variant or who were highly likely, based on local epidemiologic trends, to have been infected with an Omicron variant. Based on San Diego Wastewater Surveillance data (SEARCH GitHub repository (