Trial design
comorbidity
The FAMOUS trial is a prospective multicentre mixed methods study. Patients with at least three chronic conditions across nine participating general practices are eligible to be treated as an intervention group by a trained APN. All patients will be treated by APNs for twelve months. Data on the period of intervention are available as data from health insurance companies or the Association of Statutory Health Insurance Physicians (ASHIP) or data collected by the APN. The intervention group will be compared with a control group of patients from German health insurance who are matched according to age, sex, comorbidity and living in a nursing home. The matching will be performed at a ratio of one FAMOUS patient to two control patients.Qualitative interviews will take place with GPs, APNs and patients to assess factors that are difficult to capture using quantitative data. This evaluation procedure will be carried out by an independent institution (IMBEI). In addition, the intervention will be assessed in more detail in an internal evaluation from the trial sponsor using a longitudinal design.