Study population.
diarrhea, inadequate hepatic or renal function
POORLY CONTROLLED DIABETES MELLITUS
The study design has been previously reported (Patients were excluded if they had a history of SARS-CoV-2 vaccination or if they wished to receive vaccination during the study period. Other exclusion criteria were as follows: (i) onset of symptoms ≥8 days before enrollment; (ii) oxygen saturation measured by pulse oximetry <96% on room air; (iii) inadequate hepatic or renal function ([i] alanine aminotransferase or aspartate aminotransferase ≥5 × upper limit of the reference range, [ii] Child–Pugh class B or C, or [iii] serum creatinine ≥2 × upper limit of the reference range and creatinine clearance <30 mL/min); (iv) poorly controlled diabetes mellitus (random blood glucose ≥200 mg/dL or hemoglobin A1c ≥7.0% despite treatment); or (v) severe diarrhea. Pregnant or breastfeeding women, women who might become pregnant during the study, or patients who did not use adequate contraceptive precautions were also excluded.