Competing interests
Cancer
ONCOLOGY, EVENTS, CANCER, EMD
Alexandra Leary has grants or contracts from Agenus, Astra Zeneca, BMS, GSK, Iovance, MSD, OSE Immuno, Roche as principal investigator in clinical trials and from ARCAGY-GYENCO, AZ, Sanofi for translational research; has payment as invited speaker from Astra Zeneca, Clovis, GSK, Kephren publishing, Medscape; payment for consultancy from GLG and Orion, and payment for writing engagement from Onko+; has participation in Advisory Boards from Ability Pharma, Apmonia, Astra Zeneca, Blueprint, Clovis, GSK, Merck Serono, MSD, Tesaro and Zentaris; has participation in a steering committee from MSD; was IDMC member or chair for Clovis and Pfizer; and participated in an Academic Research Project for LX Repair and Owkin. Ana Oaknin has grants or contracts from Abbvie Deutschland Gmbh & Co Hg, Ability Pharmaceuticals, Advaxis, Agenus, Aprea Therapeutics AB, Astrazeneca AB, Beigene USA, Inc., Belgian Gynaecological Oncology Group (BGOG), Bristol‐Myers Squibb International Corporation (BMSM Clovis Oncology, Corcept Therapeutics, Eisai, F. Hoffmann‐La Roche, Grupo Español de Investigación en Cáncer de Ovario (GEICO), Immunogen, Iovance Biotherapeutics, Lilly, Medimmune, Merck Healthcare, Merck Sharp & dohme, Millennium Pharmaceuticals, Mundipharma Research, Novartis Farmacéutica, Regeneron Pharmaceuticals, Seagen, Seattle Genetics, Sutro Biopharma, Tesaro, University Health Network, and Werastem; has payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events from ESMO, Edizioni Minerva Medica SpA and Doctaforum Servicios S.L.; has support for attending meetings and/or travel from AstraZeneca; Clovis Oncology; PharmaMar, and Roche; and participation on a Data Safety Monitoring Board or Advisory Board from Agenus, AstraZeneca, Clovis Oncology, Inc., Corcept Therapeutics, Deciphera Pharmaceutical, Eisai Europe Limited, EMD Serono, Inc., F. Hoffmann‐La Roche, GlaxoSmithKline, Immunogen, KL Logistics, Medison Pharma, Merck Sharp & Dohme de España, Mersana Therapeutics, Novocure GmbH, Pharma Mar, prIME Oncology, ROCHE FARMA, Sattucklabs, and Sutro Biopharma, Inc., as well as participation to non‐remunerated activities and non‐remunerated leadership roles for GCIC and GEICO. Daniel Castellano have payment for Advisory Board or Expert Opinion from Pfizer, Roche, BMS, MSD, Astellas, Astra Zeneca, Novartis, Gilead, Ipsen, Pierre Fabre, Sanofi, Eisai, Janssen and GSK. Geoffrey. I. Shappiro has payment to Dana-Farber Cancer Institute from PharmaMar for conduct of the clinical trial; has sponsored research agreement with payment to DFCI from Merck KGaA/EMD-Serono, Merck & Co. and Lilly; has funding for investigator-initiated clinical trials to DFCI from Pfizer; consulting fees from XinThera, Inc.; has patent issued to Cyclacel Pharmaceuticals and Geoffrey I. Shapiro for dosage regimen for sapacitabine and seliciclib, and pending to Liam Cornell and Geoffrey I. Shapiro for compositions and methods for predicting response and resistance to CDK4/6 inhibition; and has participation on advisory boards for Pfizer, Eli Lilly, Merck KGaA/EMD-Serono, Bicycle Therapeutics, Fusion Pharmaceuticals, Cybrexa Therapeutics, Bayer, Boehringer Ingelheim, ImmunoMet, Asana, Artios, Atrin, Concarlo Holdings, Syros, Zentalks, CytomX Therapeutics, Blueprint Medicines, Kymera Therapeutics, and Janssen. Cristian Fernández, Carmen Kahatt, Vicente Alfaro, Mariano Siguero, Daniel Rueda and Ali Zeaiter have personal fees for salary as full time employee from PharmaMar S.A. Cristian Fernández, Carmen Kahatt, Vicente Alfaro, Daniel Rueda and Ali Zeaiter are stock ownership of PharmaMar S.A. Ahmad Awada has advisory role with Amgen, AstraZeneca, Bayer, Daiichi, EISAI, Genomic Health, Hengrui, Innate, Ipsen, Leo Pharma, Lilly, Merck, MSD, Novartis, Pfizer and Seattle Genetics; has speaker fees with Amgen, AstraZeneca, Bayer, Daiichi, EISAI, Genomic Health, Ipsen, Leo Pharma, Lilly, Merck, MSD, Novartis, Pfizer and Seattle Genetics; and has research grants to his Institute by BSM and Roche. Vivek Subbiah received grants from PharmaMar, Eli Lilly/LOXO Oncology, Blueprint Medicines Corporation, Turning PointTherapeutics and Boston Pharmaceuticals; and grants fromHelsinn Pharmaceuticals during the conduct of the study; in addition, Vivek Subbiah received a grant and advisory board/consultant position with Eli Lilly/Loxo Oncology during the conduct of the study; research grants from Roche/Genentech, Bayer, GlaxoSmithKline, Nanocarrier, Vegenics, Celgene, Northwest Biotherapeutics, Berghealth, Incyte, Fujifilm, D3, Pfizer, Multivir, Amgen, AbbVie, Alfa-sigma, Agensys, Boston Biomedical, Idera Pharma, Inhibrx, Exelixis, Blueprint Medicines, Altum, Dragonfly Therapeutics, Takeda, National Comprehensive Cancer Network, NCI-CTEP, University of Texas MD Anderson Cancer Center, Turning Point Therapeutics, Boston Pharmaceuticals, Novartis, PharmaMar and Medimmune; an advisory board/consultant position with Helsinn, Incyte, QED Pharma, Daiichi-Sankyo, Signant Health, Novartis, Relay therapeutics, Roche and Medimmune; travel funds from PharmaMar, Incyte, ASCO, ESMO; and other support from Medscape, all outside the submitted work. The remaining authors made no disclosures.