Results
neutropenia
NEUTROPENIA, FEBRILE NEUTROPENIA
Overall, 191 patients were identified, median age of 57.0 years (range 24.3–90.9); 30% were diagnosed with de novo MBC; 72% received first-line and 10% as ≥ second-line treatment. Median progression-free survival (95% CI) was 22.8 months (16.5–not reached [NR]) in first-line; NR in patients with de novo MBC; 7.8 months (6.8–NR) in ≥ second-line (median follow-up: 24 months). Median overall survival (OS) was NR in the overall cohort; OS rate (95% CI) at 24 months was 74.2% (67.1–81.9%) in first-line; 82.1% (72.6–92.8%) in patients with de novo MBC; 55.0% (37.0–81.8%) in ≥ second-line. Forty-seven per cent of patients developed grade 3–4 neutropenia; 3% febrile neutropenia.