Statistical design for translational study
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Variables following binomial distributions (i.e.: response rate), were expressed as frequencies and percentages. Comparisons between qualitative variables were made using the Fisher Exact Test or Chi-square, with Yates’ continuity correction when necessary. Comparisons between quantitative and qualitative variables were performed through non-parametric tests (U of Mann-Whitney or Kruskal-Wallis). Time to event variables (OS and PFS) were measured from the date of therapy onset and were estimated according to the Kaplan-Meier method. Comparisons between the variables of interest were performed by log-rank test. Median follow-up was calculated using the reverse Kaplan-Meier estimator. All p-values reported were 2-sided, and statistical significance was defined at p < 0.05.