2.2. Binding Antibodies to DaxibotulinumtoxinA
At baseline, 12 of 2737 (0.4%) evaluable subjects were found to have binding antibodies to BoNTA. A total of 21 of 2737 subjects (0.8%) developed treatment-induced (Most binding antibodies to daxibotulinumtoxinA were transient. In 18 of 19 subjects with further antibody tests after a positive result, their subsequent result(s) were negative. Only two subjects (#3, #16) had more than one anti-daxibotulinumtoxinA binding antibody positive result (Of the 21 subjects with treatment-related anti-daxibotulinumtoxinA antibodies, seven (33.3%) had previously received BoNTA. Overall, 18 of the 21 subjects (all except Subjects #6, #15, and #16; 