Author contributions
C.H.
Trial conceptualization: V.A., C.H., P.A.B. P.O.G., K.D. and J.D. Methodology and protocol writing: V.A., C.H., E.A., P.A.B., P.O.G., K.D. and J.D. Investigation (clinical trial): V.A., C.H., G.N., R.A.J., A.S., A.S.F., P.W.P., S.A.L., B.L., J.L.B., P.A.B., P.O.G and J.D. Investigation (experimental): V.A., A.B., N.N and M.S. Data curation: E.A. Formal analysis: L.Z and K.D. Resources: V.A., M.S, J.O.T. and J.D. Writing (original draft): V.A., C.H., M.S., E.A., P.O.G., K.D. and J.D. Writing (review and editing): all authors. Visualization: A.B., N.N. and K.D. Supervision: V.A. and J.D. Project administration: E.A. Funding acquisition: M.S. and J.O.T.