Strategies to improve adherence to interventions {11c}
As the intervention includes one clinical treatment procedure, no specific strategies exist to improve intervention adherence. However, routine outcome measures from the PRESENT cohort will be used for effect estimation. To minimize missing outcomes on the primary endpoint, a member of the research team will call patients who do not return a questionnaire within 1 week to request the patient to complete the questionnaire and to ask out their response on the primary outcome.