RESULTS
Descriptive baseline and outcome data for the 982 patients in the ITT population are presented in Table Descriptive baseline and outcome data
Abbreviations: CPAP, continuous positive airway pressure; NIV, non‐invasive ventilation.A total of 13 patients on closed systems (1.3% of the full intention‐to‐treat population; 5 patients in the 12‐mg group and 8 patients in the 6‐mg group) could not be classified due to missing FiOLow flow includes patients with oxygen flow values ≤ the median value in all patients on open systems (22 L/min), whereas high flow includes patients with values > this value.Low FiOLactate values were missing in 106 patients (10.8% of the intention‐to‐treat population; 57 patients in the 12‐mg group and 49 patients in the 6‐mg group).Calculated using the stacked multiply imputed datasets; the mean predicted risk was 38.5% in the 12‐mg group and 37.6% in the 6‐mg group.Days alive without life support at Day 90 were missing in 15 patients (1.5% of the intention‐to‐treat population; 8 patients in the 12 mg group and 7 patients in the 6 mg group).Mortality at Day 90 values were missing in 14 patients (1.4% of the intention‐to‐treat population; 7 patients in the 12‐mg group and 7 patients in the 6‐mg group).HTE according to treatment allocation and simple baseline characteristics.Figures Days alive without life support at Day 90 according to treatment allocation and baseline characteristics. Expected mean number of days alive without life support (DAWOLS) with 95% confidence intervals according to four baseline variables (as described in methods section) according to the model fit. Predicted values and 95% confidence intervals are truncated at the lowest/highest possible values (0/90 days). The Mortality Day 90 according to treatment allocation and baseline characteristics. Expected mortality rates at Day 90 with 95% confidence intervals according to four baseline variables (as described in the methods section) according to the model fit. The 