Patient response
death, tumor, high-grade glioma, glioma, glioblastoma, tumors
TUMOR, DISEASE, GLIOMA, GLIOBLASTOMA, TUMORS
Twenty-three patients were analyzed for their response to CGA. The disease control rate after 4-week injections (the first cycle) was 52.1% (SD, 12) (Summary of 17 patients with grade 4 glioma, including response assessment and overall survival, in the dose cohort, and after the first cycle and extended monotherapy with CGAC1D1, cycle 1 day 1; NA, not applicable. CGA treatment duration and patient response. (A) Summary of patient dose cohorts, patient response status assessed at the end of the first CGA treatment cycle, and the survival status after CGA treatment or combination treatment with standard-of-care therapeutics. Arrows indicate patients remaining alive at the most recent follow-up (February 11, 2022). Y axis, patient ID. X axis, time (month) from the start of CGA treatment until death. (B) Ten patients received CGA treatment at the extended time after the first cycle. Y axis, patient ID. X axis, days of CGA treatment at the extended time.According to the protocol and physician’s judgement, after 4-week treatment, the patients could continue to receive the CGA alone or in combination with other treatments. All the patients were followed up until their death. Among these patients, 10 received extended CGA monotherapy for a median of 28 days (range 14–133 days) after the first cycle (Kaplan-Meier curves of overall survival in patients with recurrent high-grade glioma who were treated with chlorogenic acid. (A) OS of per protocol set population (Interestingly, the patient with glioblastoma (GBM) (patient ID 0005) was resistant to TMZ before enrollment. After CGA treatment for 4 weeks, the tumor lesions remained stable. Subsequently, this patient continued to receive CGA treatment in combination with TMZ, and the tumor lesion began to shrink (MRI images (arrows indicate tumors) obtained at baseline, 4 weeks of treatment, and follow-up of a representative patient (ID 0005) ww chlorogenic acid treatment. Red arrows indicate tumors.