Gentleness
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Mean TEWL rates are summarized in Figure Mean trans‐epidermal water loss (TEWL) rates for the respective optical and tail regions of the OxySoftN and MaxN sensors at baseline and after the first 4‐h wear period (T1) or the second 4‐h wear period (T2)In comparing results from the optical region of the OxySoftN and MaxN sensors, it was found that at both T1 and T2, TEWL rates were significantly elevated with both devices compared to the control sites. However, no significant differences were found to exist between the two sensors at either time point.In comparing the results from the tail region of the OxySoftN and MaxN sensors, it was found that at T1, TEWL rates were significantly elevated for both the OxySoftN and MaxN sensors when compared to the control (In comparing the results obtained at T2 from the tail region, it was found that TEWL rates were significantly elevated only for the MaxN sensors when compared to the control (Further, the amount of protein removed was significantly less with the OxySoftN sensor compared to the MaxN sensor (1.3 ± 0.4 ug/ml vs. 10.1 ± 2.9 μg/ml, Interval plot comparing amount of protein adhered to the removed device. Samples for subject #16 were not suitable for measurement. The detection limit of the test was 1.2 μg/cm