Associations between systemic inflammation ratios (SIRs) and overall survival.
inflammation, Lung Cancer, ALI
INFLAMMATION, INFLAMMATION, LUNG CANCER
NLR, Neutrophil to Lymphocyte Ratio; PLR, Platelet to Lymphocyte Ratio; ALI, Advanced Lung Cancer Inflammation Index; HR, hazard ratio, CI, confidence interval.NOTE: Associations are between inflammation biomarkers and overall survival. HR indicates the difference between biomarkers above and below the specified cutoff levels. The NLR and PLR models are adjusted for ECOG-PS (dichotomized as 0–1, 2 or more), age (dichotomized as <65, 65≥), educational level (dichotomized as no college education, at least some college), smoking status, and treatment received at baseline.After adjusting for covariates, the hazard ratio (HR) for NLR is 1.91 (95% CI: 1.29, 2.84; p = 0.001). That is, patients with elevated NLR at diagnosis (higher inflammation) were approximately twice as likely to die at any time point compared to those with a lower inflammation ratio. Patients with baseline NLR<5 (47%) had an estimated one-year survival probability of 0.76 (95% CI: 0.67, 0.85), while those with NLR≥5 (53%) had a one-year survival probability of 0.46 (95% CI: 0.37, 0.57). The log-rank test was significant (p-value = 0.001) indicating a marked difference in survival (