Secondary outcomes and post-hoc analyses
NDD, anemia
REGRESSION, SECONDARY, ANEMIA, SEVERE ANEMIA
We constructed additional models for the secondary outcomes, using the logit link for binary outcomes, negative binomial distribution for count outcomes, and linear models for continuous outcomes, controlling for sex and the baseline level of the outcome variable. Our mixed model for the composite AUDIT-C/PEth variable did not converge; we instead conducted a generalized estimating equation (GEE) logistic regression model. We conducted an analysis of SDS score, to examine whether SDS increased over time in study and whether changes in SDS over time were differential by study arm. To explore discordance between self-report and PEth results, we constructed a model of NDD, including the study arm by follow-up interaction, sex, PEth (log10 ng/mL), SDS score, and the Perceived Awareness of the Research Hypothesis scale as the independent variables. We did not correct for multiple comparisons given guidance against doing so (We conducted two post-hoc exploratory analyses: 1) adding BMI and anemia to the main model of log10 PEth described above, and 2) excluding the subset of participants with BMI≥ 30 and severe anemia for whom PEth was previously observed to be less sensitive from our main log10 PEth model (