Other adverse events
hypertension, headache, somnolence
ADVERSE EVENTS, SINUS BRADYCARDIA, DISEASE, SPINAL CORD COMPRESSION, ADVERSE EVENT, EVENTS, MYELOMA, HYPERTENSION
For expected adverse events known to be associated with ketamine, apart from having a mild increase in the prevalence of grade 2 somnolence (11% - 17%) and grade 1 headache (11% - 17%) no longer than two hours of the infusion duration, there was no significant harm encountered.Apart from the expected adverse events, there were 86 reported adverse events. Regarding the causality to study intervention, 71 events (82.6%) were deemed “unrelated”, 12 events (14.0%) “unlikely”, three events (3.5%) “possible” (two events being grade 1 hypertension with systolic blood pressures between 120 and 139), and one being borderline sinus bradycardia. None of these events was serious in nature. There was one serious adverse event for hospitalisation due to the underlying disease (imaging for possible spinal cord compression in the context of myeloma), deemed unrelated to the study intervention.