Introduction
PPROM, PTD, preterm premature rupture of the membrane, pre-eclampsia
VAGINAL BLEEDING, PRE-ECLAMPSIA, PATHOPHYSIOLOGY, SECONDARY, PRETERM DELIVERY, PRETERM LABOR

Preterm labor (PTL) before the 37

Despite an intensive bulk of studies on PTL pathophysiology, there is still much controversy on its mechanism. One of the most acceptable theories is bypassing or early stimulation of “parturition complex cascade”, known to be responsible for on-time labor triggering.

The most important risk factors for preterm delivery (PTD) are a previous history of PTD, smoking, vaginal bleeding, and preterm premature rupture of the membrane (PPROM).

Due to the similarity between the mechanisms of spontaneous PTL and pre-eclampsia, it has been suggested that low-dose aspirin may also be used to prevent spontaneous PTL. Some studies have performed secondary analyses of data on the effect of low-dose aspirin on the prevention of pre-eclampsia to evaluate the effect of low-dose aspirin on the prevention of PTL. Although some studies have reported the effectiveness of low-dose aspirin in preventing PTL, other studies did not prove it.
