Pharmacokinetics of single and multiple ascending oral FMGX doses.
SAD
The graph of the MGX PK profile after oral administration of FMGX was comparable to that after i.v. infusion of FMGX (MGX concentration profile after single and multiple ascending oral FMGX doses. (A) SAD cohorts; (B) MAD cohorts. Data are presented for study 2 cohorts 1a and 1b (A) and cohorts 2 and 3 (B) as geometric mean MGX plasma concentrations for participants in the PK population (MGX pharmacokinetic parameters after single and multiple ascending oral FMGX dosesData are presented for study 2 as the geometric mean (geometric %CV) for the PK population. The i.v. dose was infused over 3 h; doses were administered daily for the MAD segment. The SAD and MAD phases were conducted under For single-dose administration, the median 