2.3. Analysis of Overlapping Metabolomic Profiles in the Human OP and the Rat RYGB Group
Thirty-one metabolites with significant differences in both OP vs. LS and RYGB_rat vs. BWM_rat could be identified (see In terms of individual metabolites, six amino acids with a significant difference between RYGB_rat and BWM_rat were also found to be significantly different in the Analyzing the phosphatidylcholines with ester bonding, eleven PCs could be identified to be significantly different in both comparisons: PC aa C32:0 (16.0 µM in LS vs. 18.5 µM in OP; 5.7 µM in BWM_rat vs. 11.4 µM in RYGB_rat), PC aa C34:1 (257 µM in LS vs. 283 µM in OP; 66 µM in BWM_rat vs. 106 µM in RYGB_rat), PC aa C38:1 (0.62 µM in LS vs. 0.97 µM in OP; 0.43 µM in BWM_rat vs. 1.08 µM in RYGB_rat), PC aa C38:5 (44.1 µM in LS vs. 52.1 µM in OP; 24.3 µM in BWM_rat vs. 40.5 µM in RYGB_rat), PC aa C40:2 (0.16 µM in LS vs. 0.19 µM in OP; 0.26 µM in BWM_rat vs. 0.51 µM in RYGB_rat) and PC aa C40:5 (6.5 µM in LS vs. 8.0 µM in OP; 5.7 µM in BWM_rat vs. 9.2 µM in RYGB_rat).Five of these PCs are characterized by forty-two carbon atoms (PC aa C42:Y): PC aa C42:0 (0.29 µM in LS vs. 0.35 µM in OP; 0.06 µM in BWM_rat vs. 0.10 µM in RYGB_rat), PC aa C42:1 (0.13 µM in LS vs. 0.16 µM in OP; 0.08 µM in BWM_rat vs. 0.11 µM in RYGB_rat), PC aa C42:4 (0.09 µM in LS vs. 0.12 µM in OP; 0.13 µM in BWM_rat vs. 0.20 µM in RYGB_rat), PC aa C42:5 (0.21 µM in LS vs. 0.28 µM in OP; 0.13 µM in BWM_rat vs. 0.28 µM in RYGB_rat) and PC aa C42:6 (0.24 µM in LS vs. 0.29 µM in OP; 0.31 µM in BWM_rat vs. 0.49 µM in RYGB_rat).Twelve phosphatidylcholines with ether bonding were found to be significantly different in the Finally, two out of five sphingolipids with a significant difference in the 