Introduction
colorectal cancer, major depression, postoperative pain, CRC, anxiety, cancer, pain, chronic pain
CANCER, COLORECTAL CANCER, CHRONIC PAIN, ADVERSE EFFECTS
GLOBOCAN 2018 reported that colorectal cancer (CRC) is the third most deadly and fourth-most common cancer worldwide [Multi-modal analgesia is advocated for perioperative pain management, to reduce opioid use and its associated adverse effects [Duloxetine is a serotonin-norepinephrine reuptake inhibitor (SNRI) commonly prescribed for the treatment of major depression and anxiety; it has also been used in the treatment of chronic pain conditions [We hypothesized that the incorporation of perioperative oral duloxetine doses would produce a reduction in postoperative pain intensity, opioid consumption, and quality of recovery for patients subjected to colorectal surgery.