Ethical approval, clinical trial registration, and informed consent
The Ethical Committee of the College of Applied Medical Science, Majmaah University, Majmaah, Saudi Arabia, approved the study (Ethics number: MUREC-Jan. 25/COM-2021/19-5). This study has been registered in a clinical trial registry (clinicaltrial.gov, ID: NCT05056792 on 27/09/2021). The study conforms to ‘The Code of Ethics of the World Medical Association (Declaration of Helsinki)’. Participants were given a detailed description of the study, its procedure, benefits, and harms before applying any intervention. All methods were performed following the relevant guidelines and regulations. All participants voluntarily gave their written informed consent.