Adequacy of the Estimation Models for Differences in Risk Between Treatment Groups
For each cognitive outcome and for each covariate set, we summarized the adequacy of the modified elastic-net model to estimate the risk differences in the cognitive outcome between treatment groups by dividing the cohort into tertiles of the estimated risk differences and comparing the observed risk differences (estimated from the Kaplan-Meier curves within tertiles at 4.13 years) to the estimated risk differences under the model. We report the observed risk differences in association with the estimated risk differences on the aforementioned risk amplification plots, where the 95% CIs for the observed risk differences are marked for all tertiles.