Author contributions
CN led the design of the methods, wrote the main manuscript text and is responsible for the overall conduct of the study. AF, JF, AA, TS, JA and RG performed the preliminary laboratory assays for method development and mosquito strain selection and contributed to the design of the data collection tools, laboratory bioassays and hut trials. TC designed the mathematical modelling component and contributed to sample size calculations and data analysis plans. CN, AF, JF, TS, RG and MA prepared the figures and tables. CN, MA, NP, JC, GP and MCA. are responsible for the management of the cluster randomized controlled trial in Benin and contributed to manuscript revision. All authors reviewed the manuscript.