Safety
any-grade, TEAEs, TRAEs
Almost all participants (96.43%) experienced any-grade TEAEs. Any-grade TEAEs leading to anlotinib dose modification were observed in 35.71% of patients. TEAEs leading to anlotinib dose interruption were observed in 14.29% of cases. TEAEs leading to etoposide dose modification were observed in 7.14% of participants (Table 
Summary of TEAEs in the ITT set (n = 28)ITT: intent-to-treat; TEAE: treatment emergent adverse eventsGrade 3–4 TRAEs were observed in 42.85% of participants. Grade 3–4 TEAEs leading to anlotinib dose modification were observed in 28.57% of cases. TEAEs leading to anlotinib dose interruption were observed in 7.14% of patients. TEAEs leading to etoposide dose modification were observed in 7.14% of participants (Table 