Clinical End Points
The primary end point for this analysis was the change in 24‐hour, daytime, and nighttime BP from baseline to 8 weeks in patient subgroups based on nocturnal BP dipping status (dipper and nondipper). Secondary end points included the following: change from baseline to 8 weeks in 24‐hour BP; change from baseline to 8 weeks in levels of NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide); changes from baseline to 8 weeks in 24‐hour, daytime, and nighttime BP in patient subgroups based on baseline characteristics; rates of BP control at 8 weeks, where BP control was defined as 24‐hour SBP <130 mm Hg and 24‐hour diastolic BP (DBP) <80 mm Hg; safety in patient subgroups based on nocturnal BP dipping status; and between‐group differences in change from baseline to 8 weeks in the daytime and nighttime SBP.