4.1. Challenges and limitations
TPO-RAs
THROMBOCYTOPENIA
A limitation of this study is the small sample size that limits the conclusions, especially those regarding observations drawn from subgroups of patients. Nonexperimental observational studies typically involve a more diverse group of patients than experimental and interventional clinical studies and more accurately reflect real-world medical practice. Future larger real-world studies should help to elucidate the potential use of TPO-RAs prior to procedure in this challenging patient population. Further evidence may allow for shift in the risk/benefit calculation for more invasive procedures in patients with CLD-associated thrombocytopenia.