Interim analyses
RECRUITMENT
The independent REVISE data monitoring committee (DMC) includes professor Roberts (Oxford), Dr. McAuley (Queen’s University of Belfast), and Dr. Thomlinson (Chair, University of Toronto). When 1200 patients were enrolled, the DMC reviewed 90-day mortality data and recommended continuing REVISE.When 2400 patients (50% recruitment) had 90-day mortality ascertained, we conducted a single interim analysis of all outcomes. To maintain the overall type-I error rate (i.e., Guided by their charter [