Treatment intervention
toxicity, toxicities
Naltrexone was administered to patients daily in escalating doses. Study subjects were given 10 mg of naltrexone orally once daily for one week, then 25 mg daily for one week, and then further increased to a maximum of 50 mg daily as tolerated. Naltrexone was held for any grade 3 or 4 toxicities. Once the toxicity had resolved, the therapy was resumed at the next lower dose, with dose reductions as follows: 50 to 25 mg daily, 25 to 10 mg daily, 10 mg to 5 mg daily or 5 mg daily to every other day.