Acknowledgements
We are grateful to the NIHR (HTA) programme for commissioning this study, and to the NIHR Biomedical Research Centres at Cambridge University Hospitals NHS Foundation Trust, Birmingham Children’s Hospital, Southampton Children’s Hospital, St George’s University Hospital London, John Radcliffe Hospital Oxford and Bristol Royal Hospital for Children for supporting the study at their sites. The sponsor (Cambridge University and Cambridge University Hospitals NHS Foundation Trust) and the clinical trials unit (ICNARC) provided tremendous support to overcome logistical and study process hurdles to deliver this feasibility study in a timely manner. The study would not have been possible with the consent and participation of children admitted to the PICUs involved in the study and their parents, along with the PICU, microbiology and pharmacy staff who undertook the study in a backdrop of NHS recovery from the COVID-19 pandemic and all the restrictions and clinical pressures that imposed. Outside of the PICnIC study sites, clinicians working in PICUs across the UK and their allied team members regularly reviewed and advised on study development and progress as part of the Paediatric Critical Care Society Study Group.