Study design and participants
RECRUITMENT
This was an interventional study with a cross-over design. Approval was obtained from the Research Safety Ethics Review Committee of the Tokyo Metropolitan University Arakawa Campus (approval number: 20021) and the Tokyo Metropolitan Rehabilitation Hospital (approval number: 2021–10). All participants were informed, both orally and in writing, about the content of the research, and a letter of informed consent was obtained from each participant before their enrolment. A participant in this study (This study was conducted in a quiet laboratory environment in Tokyo Metropolitan Rehabilitation Hospital and Tokyo Metropolitan University. The period of study, including recruitment period was from 1 April 2021 to 31 March 2022.The following criteria were established to exclude a possible reduced response to NMV: (1) healthy participants under 65 years of age [