Economic Analysis
Between-arm differences in costs and QALYs were analyzed using generalized linear models with bootstrapped 95% CIs adjusted for prespecified T1 covariates and CHU9D scores. Adjustment for differences in T1 costs was not possible as service use data were not collected in Co-SPACE; the CA-SUS was administered at T2 and T3 only. The primary economic analysis was a cost-utility analysis at T2. Costs were calculated from the National Health Service and personal social services perspective. Effects were measured in terms of QALYs. Incremental cost-effectiveness ratios were calculated, and nonparametric bootstrapping was used to propagate sampling uncertainty surrounding the mean incremental cost-effectiveness ratios by generating 1000 estimates of incremental costs and QALYs [