1. Introduction
cancer, tumor
CANCER, TUMOR
Curcumin is a natural ingredient with antioxidant effects, widely studied as a treatment for various types of cancer. However, its effects on ultraviolet radiation have not been fully explored. The effects of single or daily application of 0.1–100 μM curcumin on cell apoptosis in ultraviolet B (UVB)-induced mice were tested using an experimental double-blind posttest design with a control group and two research models: a single application of curcumin before a single UVB exposure and daily application of curcumin for 7 days before a single UVB exposure on the seventh day. Apoptotic cells were counted using a tunnel system kit. The number of apoptotic cells under a single or daily application of curcumin for 7 days was significantly lower than that of the UVB controls (Curcumin is a polyphenolic compound extracted from turmeric (Topical curcumin at a dose of 30 µM can induce apoptosis in several tumor cells, thereby reducing cell cycle progression and preventing the growth of cancer cells [This study aimed to explore the preventive effect of topical curcumin on UVB-induced mice by histopathologically examining the number of apoptotic cells using two different study designs. The first group was applied with topical curcumin in four concentrations once, followed by a single UVB exposure. The second group was applied with topical curcumin in four concentrations once daily for 7 consecutive days, followed by a single UVB exposure. Biopsy was then performed to determine the number of apoptotic cells. The optimal number of applications and concentration were also determined for the potential use of topical curcumin as a photoprotective agent.