Target stability over time
Nine TBI-D subjects were randomized to active treatment and four were randomized to sham. For each of the three targeting methods, connectivity with the normative sgACC seed map was calculated for pre-treatment and post-treatment scans. Two-way ANOVA was used to compare the three targeting methods in terms of difference in connectivity between the two time points. Again, it should be noted that only individualized RSNM-based targeting was performed.Euclidean distances between pre-treatment and post-treatment targets were calculated for RSNM and sgACC-derived targets to assess the stability of target location. Due to non-normal distribution of these distances, a Wilcoxon matched-pairs signed-rank test was used to compare the two targeting methods in terms of stability over time.