Statistical analysis
REGRESSION
Sample size calculation was performed by means of power analysis for matched case–control studies [The estimated number of subjects needed for the advanced brain imaging analysis, computed by power analysis for a two-sample means test [Once the desired sample size of 264 participants had been achieved, it became clear that the number of patients included in the advanced brain imaging analysis was insufficient – only 26 patients were recruited. This was due to the additional, more stringent inclusion criteria for the imaging cohort. Thus, we decided to increase the total sample size by issuing additional envelops in the described above manner until that number reached 34.The descriptive statistics included median (M) with the interquartile range (IQR) for non-normally distributed continuous data and percentage for categorical data.Groups were compared with the Mann–Whitney U test and Pearson’s χOdds ratio (OR) was calculated with binary logistic regression followed byThe STATA v.14.2 (StataCorp, USA) and IBM SPSS Statistics v.26 (IBM Corporation, USA) software packages were used for statistical analysis.