Data Collection
depression, paresthesia, CIPN, anxiety
PARESTHESIA
Baseline data including age, body mass index (BMI), gender, race, CIPN severity, hemoglobin, hemoglobin A1c, thyroid stimulating hormone (TSH), Vitamin B6, B12, and D levels, as well as the presence of anxiety or depression, were retrospectively extracted from the electronic medical record (EMR) on the first day of treatment or up to 4 months prior to chemotherapy initiation.Severity of CIPN was defined according to the NCI-CTCAE v4.0 guidelines: grade 1 CIPN or paresthesia; grade 2 CIPN or moderate symptoms limiting instrumental activities of daily living; grade 3 CIPN or severe symptoms limiting self-care activities of daily living; and grade 4 CIPN, or life-threatening consequences for which urgent intervention is indicated.Chemotherapy dosing was also extracted from each participant at the conclusion of the twelve-week treatment period in the EMR. Chemotherapy cumulative relative dose intensity was calculated by dividing the total chemotherapy dose received by the total chemotherapy dose planned. Per protocol, chemotherapy dosage adjustments were at the discretion of the treating provider.Breast cancer recurrence and breast cancer-free survival were determined at the average follow-up period of 61 months (± 6 months) and confirmed at the time of retrospective chart review.