Acknowledgements
The research leading to these results has received funding from Fondazione AIRC under 5 per Mille 2018—ID.21073 project—P.I. Maio Michele, G.L. Anichini Andrea, G.L. Ceccarelli Michele and from AIRC under IG 2018—ID. 21846 project—P.I. Ceccarelli Michele. This work was also supported by the Italian Ministry of Research Grant PRIN 2017XJ38A4_004 and from the Ministry of Health, Lombardy and Tuscany regions, Bando Ricerca Finalizzata, grant number NET-2016-02361632, Program P.I. Michele Maio, P.I. work package 2 Andrea Anichini. We thank Astex Pharmaceuticals Inc. that provided the study drug guadecitabine.