Secondary cognitive outcome responses
SECONDARY
There was no significant effect of the intervention on any of the secondary composite or individual cognitive outcomes, with the exception of reaction time variability (Cognitive secondary endpoints and response to intervention as per protocol analysisData are mean (SD); ANCOVA using mixed models for repeated measures. TREATMENT was fitted as a fixed between-group factor (2 levels: intervention or control group). Change from baseline was calculated for all outcome variables (ie, 3 mo-0 mo and 12 mo-0 mo), and VISIT was fitted as a fixed repeated factor (2 levels: 3 and 12 mo). BASELINE (predose scores), study site, BMI, and years of education were added as covariates in the final model.part of the CDR test batterya composite measure; Verbal Fluency C1- condition 1, letter fluency, total correct and scaled for age; Verbal Fluency C3a- condition 3, category switching, total correct responses and scaled for age; # Number of items. CDR, Cognitive Drug Research; OM3FLAV, omega-3 polyunsaturated fatty acids (EPA+DHA; OM3) + cocoa flavan-3-ols (FLAV).