Conclusion
depression
DISEASE
A global approach strengthening collaborations between social and health systems proved promising. Social support may contribute to preventing or reducing caregiver depression at 1 and 2 years and therefore prevent deterioration in global caregiver QoL. If randomized studies are needed to further define and investigate personalized reliable interventions, a greater use of the large currently available expertise of social workers, supported by already existing nationwide networks is also a contributory promising approach. This social involvement would allow to better reach the caregivers, in a complementary and consistent manner, to provide better identification and characterization of caregivers, and a better understanding of caregiver needs, especially early in the course of the patient disease. Timely organization of dedicated scalable support to the caregivers the most in need could be implemented. Tailored interventions from all available sources, including help provided by the social system, are required to adequately support this important, vulnerable, and still too invisible population.The authors thank all the investigators and all clinical research assistants involved in the study. We also would like to thank the Aidants Attitude organization for the booklet and all patients and caregivers that participated in the study. The authors want to mention that the large program ICE was initiated by the late Professor F. Bonnetain, responsible of the methodology and quality of life in cancerology unity of the hospital of Besançon, France. The Communal Centers for Social Action of Dijon and Besançon, the General Council of the Doubs and the Territoire de Belfort; the Caisse d’Assurance Retraite et de la Santé au Travail Bourgogne and Franche-Comté and the Agricultural Social Mutual provided social workers for the social support. We acknowledge the availability of an online pre-print via the link 