Liver
EVENTS, LIVER
Liver parameters included ALT, aspartate transaminase (AST), albumin, alkaline phosphatase, total bilirubin, and Hy's Law (Incidence of Abnormal Laboratory Tests in the Total Study PopulationResults shown are confirmed events, defined as a consecutive abnormal laboratory value on next measurement after the initial observation and on a different day, unless specified otherwise. If there is no consecutive test to confirm, the initial observation is presumed confirmed.Elevated levels on two consecutive measurements at least 7 days apart with all values between the initial and subsequent test also above (or below) the specified threshold.ALT and total bilirubin must meet the criteria on the same day.BL, baseline; ALT, alanine transaminase; AST, aspartate transaminase.No marked effect of GalNAc-conjugated ASO treatment on ALT levels was observed over time by dose category, with mean values remaining within the range of normal during the treatment period for both monthly and weekly dose regimens (Mean sentinel laboratory tests over time by dose regime cohort, monthly (