Background and rationale {6a}
ascites, cirrhosis, Liver cirrhosis, deaths, variceal bleeding, TIPS
ASCITES, CIRRHOSIS, LIVER CIRRHOSIS, COMPLICATION
Liver cirrhosis is a major cause of global health burden with 31 million disability-adjusted life years and 1 million deaths worldwide in 2010 [The transjugular intrahepatic portosystemic shunt (TIPS) is placed under radiological control and communicates the portal vein with a hepatic vein, leading to a reduction in portal pressure. Use of this shunt is part of the standard of care in patients with variceal bleeding and refractory ascites [Two pilot studies have evaluated the use of TIPS in classical HRS type 1. One included only patients who had had a response to midodrine, octreotide, and albumin. From the 14 patients with HRS type 1, only 10 had a response to treatment, of which 5 could receive TIPS. After 6–30 months of follow-up, all patients with TIPS were alive (1 with liver transplantation), while in the other group, 3 had died (and 2 were alive with liver transplantation) [Furthermore, previous studies in the setting of another complication of cirrhosis, namely variceal bleeding [