Patient-reported outcome measures (PROMs)
pain
Patients treated with TUN reported significantly less pain than CAF during the surgical intervention (MD =  − 16.4; 95% CI: − 31.0/ − 1.9; During the 2 weeks postoperative period, patients treated with TUN reported less pain compared with the ones treated with CAF (Fig. Self-reported pain, medications, PREMs, and OHIP-14 during the 14-day postoperative period. Blue continuous line: subjects treated with CAF. Orange dashed line: subjects treated with TUN. Patients treated with TUN reported also lower PREMs scores during the 2-week postoperative period, being the differences at days 10 and 14 statistically significant (Table S6). Similarly, TUN patients reported lower OHIP-14 values compared to the CAF ones between days 8–14, being these differences statistically significant at days 11, 13, and 14 (Table S7). At 6 months, OHIP-14 and condition-specific HRQoL did not differ between groups (Tables S8 and S9).