Neuroimaging data acquisition and analysis
Three-dimensional T1-weighted MRI images were collected at baseline and four-week follow-up at the UBC MRI Research Centre on a Philips Achieva 3.0 T scanner and UofC on a GE 3.0 T MR750w scanner. The scanning parameters of the Philips Achieva scanner were: number of axial slices = 155; repetition time (TR) = 6.6 ms; echo time (TE) = 3.0 ms; flip angle (FA) = 8 degrees; field of view (FOV) = 240 mm × 240 mm × 155 mm; slice thickness = 1 mm. The scanning parameters of the GE scanner were: number of axial slices = 176; TR = 8.1 ms; TE = 3.2 ms; FA = 16 degrees; FOV = 256 mm × 256 mm × 176 mm; slice thickness = 1 mm.The FreeSurfer image analysis suite (version 7.1.0, 