Conclusions
hypogonadism, prostate cancer, acute urinary retention, prostate
HYPOGONADISM, BPH, PROSTATE CANCER, PROSTATE
In this randomized clinical trial of men with hypogonadism who were carefully evaluated to exclude those at high risk for prostate cancer and followed using a standardized monitoring plan, TRT was associated with low and similar incidences of high grade or any prostate cancer, acute urinary retention, and invasive surgical procedures for BPH compared with a placebo. Testosterone replacement therapy did not worsen LUTSs. The concern about prostate risk heavily influences decision-making by clinicians and patients who are considering TRT for hypogonadism. The study’s findings will facilitate a more informed appraisal of the potential risks of TRT.