Viral correlatives: pharmacokinetics and pharmacodynamics analyses
CAVITY
Pharmacokinetics and pharmacodynamics of VSV-IFNβ-TYRP1 were monitored by measuring VSV-nucleocapsid (N) RNA in whole blood by RT-qPCR and by analyzing plasma IFNβ levels using a IFNβ specific ELISA kit (PBL Assay Science, cat #41415, RRID : SCR_006852), respectively. Viral shedding into the buccal cavity and urine was analyzed using RT-qPCR for VSV-N RNA (