Criteria for premature withdrawal
EVENT
In the event of the attending consultant or critical care dietitian having any clinical concerns relating to a patient in the ketogenic arm, a switch to standard feeding occurred. Feeding guidelines included the use of prokinetic drugs, but ultimately their use was at the discretion of the treating clinicians, as is the case for routine clinical care. In the event that a protocol deviation occurred, data continued to be accrued to inform future studies. Protocol violations included meeting less than 80% of prescribed energy and protein over the period of the study protocol (10 days), cross-over between study arms, and need for parenteral nutrition or post-pyloric feeding.