Primary and Secondary Trial Outcomes
stroke
REGRESSION, STROKE, TRANSIENT ISCHEMIC ATTACK
Abbreviations: AOR, adjusted odds ratio; ARD, adjusted risk difference; DNT, door-to-needle time; DPT, door-to-puncture time; EVT, endovascular thrombectomy; ICC, intracluster correlation; IV rtPA, intravenous recombinant tissue plasminogen activator.Results were yielded from generalized estimating equation logistic regression models and adjusted for the hospital clustering effect and temporal trend (period).Results were yielded from generalized estimating equation logistic regression models and adjusted for the hospital clustering effect, temporal trend (period), and imbalanced baseline covariates (medical history of stroke or transient ischemic attack, medication history of antiplatelet agent and statin, and hospital location).A total of 1423 of 11 821 patients discharged alive (12.0%; 856 of 5543 [15.4%] in the intervention period vs 567 of 6278 [9.0%] in the control period) had missing modified Rankin Scale scores because of loss of follow-up.We also assessed the components of reperfusion therapy. The rate of IV rtPA administration among eligible patients who arrived within 3.5 hours of symptom onset was 51.1% (2830 of 5540) in the intervention period compared with 41.4% (2612 of 6316) in the control period; the rate of EVT among eligible patients who arrived within 4.5 hours of symptom onset was 36.5% (270 of 739) in the intervention period compared with 30.6% (236 of 772) in the control period. Baseline characteristics between patients with and without mRS scores at 90 days were largely comparable (eTable 2 in 