Ethics approval and consent to participate
The medical ethics review committee of the Amsterdam UMC, location VUMC (reference number 2020.0752, approved on 21 January 2021) approved the InventCOVID trial and written informed consent for the use of clinical data, PiCCO measurements and blood samples was obtained from the patient or their legal representatives. The trial was conducted according to the principles of the World Medical Association’s Declaration of Helsinki.