Author contributions
HT
All authors contributed to the conception and conduct of this clinical trial. SY designed and wrote the protocol and the manuscript. AN, FK, KN, JY, YK, RY, and FY designed and discussed the protocol. TT, YA, MI, SH, TO, YK, TY, MI, HU, SK, YS, SU, HT, MY, YM, YY, KK, HY, KI, AM, and KN helped with implementation. YU and YN will monitor the data set. RK and AH designed the statistical analysis. SY is the principal investigator. All authors contributed to and approved the final version of the manuscript.