Feeding regimens
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The ketogenic enteral feed was reconstituted for each patient in a clean kitchen area of the ICU by research nurses, with the proportions of individual nutritional components used devised by a dietitian using K.Quik® (Vitaflo International Ltd, Liverpool, UK), Renapro® (Stanningley Pharma, Nottingham, UK), Maxijul® (Nutricia, Liverpool, UK) and Fresubin® 5 kcal (Fresenius Kabi, Dublin, Ireland, if additional fat was needed). Ketogenic and standard enteral feeding regimens were provided continuously as per the standard protocol for each trust.Patients were ineligible if they received 