Study scheme.
SECONDARY
The study included three periods—profiling, intervention and follow-up illustrated as a timeline (x-axis). Each row is a type of measurement processed from a specific time point (circles) or continuously (rectangles). Study defined primary outcomes are measures of glycemic response, secondary outcomes are blood tests and anthropometrics, and exploratory outcomes include oral and gut microbiome, serum metabolites and cytokines. Time above 140 daily time of blood glucose levels above 140 mg/dL, HbA1c glycated hemoglobin, OGTT oral glucose tolerance test. Figure adjusted with permission from Ben-Yacov et al.The PPT diet was based on a machine learning algorithm that integrates meal’s nutrient composition, blood tests, anthropometrics, lifestyle and gut microbiome features to predict an individual’s postprandial glycemic responseCompared to the profiling period, participants assigned to the PPT diet significantly increased their diet lipid intake by 14.75% ± 6.21 (mean ± standard deviation, Bonferroni corrected 