Introduction
IBD, fatigue
INFLAMMATORY BOWEL DISEASE
High doses of oral thiamine improve clinical scores of fatigue in patients with quiescent inflammatory bowel disease (IBD) and chronic fatigue (Bager et al. Thiamine is essential for carbohydrates metabolism and mitochondrial adenosine triphosphate (ATP) production. Absorption of dietary thiamine occurs in the small intestine by a saturable, carrier-mediated active process at low doses (oral intake less than 5 mg) and by a passive diffusion process at high doses (Hrubša et al. In the TARIF clinical trial (ClinicalTrials study identifier NCT036347359), we found that high doses of oral thiamine hydrochloride administered for 4 weeks were able to reduce fatigue levels in patients with quiescent IBD and chronic fatigue (Bager et al. In the TARIF study, blood samples were collected for analyses of B-vitamins and metabolites. In addition to samples from 40 patients with quiescent IBD and chronic fatigue, blood samples from 20 matched patients with quiescent IBD and no fatigue were collected. This allowed us to:compare the plasma levels of selected B vitamins, related vitamers and metabolites between chronic fatigued patients with quiescent IBD and non-fatigued patients with quiescent IBD;examine plasma levels of selected B-vitamins, related vitamers and metabolites between chronic fatigued patients with quiescent IBD with or without positive effect of high doses of oral thiamine.