Interpretation of scores
Although overall symptoms VAS is not a verified anchor, it was identified as the overall measure of stability and improvement in patients with severe CRSwNP, as this was the only anchor sufficiently correlated (r ≥ 0.3) with SNOT-22 scores (polyserial correlation coefficient: − 0.558). Using the overall symptoms VAS as an anchor to classify patients as stable or minimally improved (minimal improvement was arbitrarily defined as − 2 ≥ change score ≥ − 4, based on EPOS guidance for severity [Mean change in SNOT-22 score by VAS anchor in total ITT population. Overall VAS anchor groups were defined by change in overall VAS symptom score from baseline to Week 52: moderate to major improvement: ≤  − 4-point change in VAS score; minimal meaningful improvement: ≤ − 2 to > − 4-point change in VAS score; limited improvement or worsening (stable): > − 2 to < 2− point change in VAS score; CDF plot: change from baseline in SNOT-22 total score by overall VAS anchor. Overall VAS anchor groups were defined by change in overall VAS symptom score from baseline to Week 52: moderate to major improvement: ≤ − 4-point change in VAS score; minimal meaningful improvement: ≤ − 2 to > − 4-point change in VAS score; limited improvement or worsening (stable): > − 2 to < 2-point change in VAS score. 