Ethics approval and consent to participate
The trial in the manuscript was registered at the Chinese Clinical Trial Registry, a member of the World Health Organization international clinical trials registry (Registry Number: ChiCTR1900021821; Registry Time: 03/11/2019). This study was approved by the ethics committee of Shanghai Ninth People’s Hospital affiliated with Shanghai Jiao Tong University, School of Medicine (Number: SH9H-2018-T88-2; Registry Time: 04/03/2019). All the methods in the trial were carried out in accordance with relevant guidelines and regulations. All participants permitted this study and signed an informed consent agreement. For participants that are minors, informed consent have been obtained from a parent and/or legal guardian.