Sample size calculation and statistical analysis
alopecia
ALOPECIA
This study was designed to achieve 80% power to detect 35% improvement in patients' thermal comfort response, with a margin of error of 5%. In total, 20 patients were required per study arm, considering a margin of 15% lost to follow-up or non-evaluable for the primary endpoint.We evaluated the impact of age (≤ or > 50 years), alopecia (grade 0 or 1/2), chemotherapy regimen (with or without taxanes), and EHW use (yes or no) in the different comfort scales using Fisher’s Exact Test. Due to the difference in number of cycles that each patient could receive, we considered each patient questionnaire during the chemotherapy session as an individual sample and compiled them to compare the two arms. Statistical analyzes were evaluated using R Statistical Programming Language version 4.1.2