RMS values (in μm) at baseline and consecutive measurements.
The RMS values at 4 and 12 weeks were compared with the values of the baseline using the Wilcoxon test. All p-values were adjusted for 2 comparisons according to the Bonferroni method. An asterisk with the corresponding p-value indicates a significant change compared to the baseline. RMS = Root Mean Square; μm = micrometer; CN = cationic nanoemulsion; F6H8 = perfluorohexyloctane.At baseline the NIBUT between the three groups did not differ significantly (H (2) = 4.7; p = 0.09). After 4 weeks there was no statistically significant difference between the groups (H (2) = 4.8; p = 0.09). After 12 weeks CN increased NIBUT statistically significant from 9.9 ± 5.3 seconds at baseline to 15.5 ± 5.6 seconds (z = -2.4; p = 0.04). The effect size was r = 0.4. This represents a medium effect. F6H8 increased NIBUT from 12.4 ± 5.9 seconds at baseline to 16.9 ± 4.7 seconds (z = -2.6; p = 0.02) after 12 weeks (