Exploratory End Points
fibrosis
FIBROSIS, MRS
A variety of exploratory end points were defined in the trial protocol as well as the trial statistical analysis plan. These included measures of energy metabolism at rest and during dobutamine stress, assessment of myocardial triglyceride content (MTG) by proton MRS, cardiac function and volumes at rest and during dobutamine stress, measures of cardiac fibrosis (late gadolinium enhancement, extracellular volume, and shortened modified look-locker inversion recovery [ShMOLLI]) T1, as well as blood biomarkers relating to drug effects on metabolism or neurohormonal activation. A full list of exploratory outcomes is provided in the trial statistical analysis plan in the 