Outcomes
nocturnal reduction
The main outcomes used to evaluate the effects of controlling 24-h IOP were: (a) mean 24-h IOP (the average IOP over the entire 24-h period for each visit) at baseline and 1, 4 and 12 weeks after treatment initiation; (b) peak IOP (the highest IOP over the entire 24-h period for each visit) at baseline and 1, 4, and 12 weeks after treatment initiation. (c) 24-h IOP fluctuation (the peak IOP minus the trough IOP over the entire 24-h period for each visit) at baseline and 1, 4, and 12 weeks after treatment initiation. (d) IOP reduction from baseline at 1, 4, and 12 weeks after treatment initiation, including 24-h reduction (the post-treatment mean 24-h IOP at each follow-up time point minus the baseline mean 24-h IOP), diurnal reduction (the post-treatment mean IOP at 7:00, 10:00, 14:00, and 18:00 for each visit minus the baseline mean IOP at the same times), and nocturnal reduction (the post-treatment mean IOP at 22:00, 2:00, and 5:00 for each visit minus the baseline mean IOP at the same times).