Antisaccades in PD and the potential influence of DBS frequency
PD, tremor
When ask to perform antisaccades persons with PD tend to higher rates of erroneous prepotent saccades towards, instead of away from the stimulus, than healthy controls (With 130 Hz as the default stimulation frequency, most patients are treated with DBS pulses between 60 and 200 Hz. A differential effect on several clinical hallmarks of PD has empirically evolved with higher frequencies enabling tremor control and lower frequency stimulation (60 to 90 Hz) possibly improving gait function and axial symptoms (Interestingly, axial motor signs, and specifically freezing of gait, paralleled antisaccade performance in several recent trials (In this study, we combined eye-tracking and EEG recordings with the aim to explore effects of high (130 Hz)- versus mid-frequency (60 Hz) STN-DBS versus no stimulation on response inhibition and its cortical correlates in the antisaccade task in PD.