Primary and secondary outcome measures
SECONDARY
The primary outcome is 7-day point prevalence tobacco abstinence (PPA) at the week 12 EOT study visit, measured via biochemical verification and self-report. The secondary outcome is changes in cannabis use during tobacco cessation treatment. Among participants co-using cannabis, cannabis use frequency and amounts during the final 4 weeks of tobacco treatment (weeks 8–12) will be assessed and nicotine dependence at baseline will be the primary model predictor. Finally, we will assess cannabis co-use severity on tobacco cessation outcomes as an exploratory aim.