Quality of life
diarrhoea
The quality of life was measured according to the questionnaires EORTC-QLQ and OVAR28. At least one quality of life (QoL) questionnaire was completed by 5 (50%) of 10 patients in the phase I part and 37 (54%) of the 50 participants treated within the phase II participants at baseline. Statistically significant worsening was observed for physical functioning, role functioning, and emotional functioning, nausea/vomiting and diarrhoea. Global quality of life was worsening, especially from pre chemotherapy (baseline) until after the end of chemotherapy without statistical significance.