Randomization and allocation concealment
Forty-eight patients were randomized into two treatment groups. A computer-generated randomization table was created. Patients were assigned unique numbers from 1 to 48, and 2 sets of randomized numbers were generated (24 for control group subjects and 24 for test). Allocation concealment was performed using sealed envelopes to be opened before periodontal treatment. The generation of the random sequence allocation and the assignment of participants to interventions were performed by the investigator, distinct from the clinical examiner and the clinician who performed the treatment.