Outcomes
death, Toxicity, Cancer
ADVERSE EVENT, RECURRENCE, METASTASIS, ADVERSE EVENTS, DISEASE, SECONDARY, CANCER
The primary endpoint was 2-year local control rate in all enrolled patients. Local control was defined as no recurrence in the esophageal anastomosis or lymph nodes in the radiation field. The secondary endpoints included overall survival (OS), disease free survival (DFS), local-regional recurrence free survival (LRFS), distant metastasis free survival (DMFS) and adverse events. Overall survival was defined as time from the date of surgery until death. DFS was defined as the time from the date of surgery to the date of recurrence, metastasis or death, whichever occurred first. LRFS was defined as the time from the date of surgery to the date of local-regional recurrence or death, whichever occurred first. DMFS was defined as the time from the date of surgery to the date of distant metastasis or death, whichever occurred first. Toxicity was graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE 4.0).