SOCS5 suppressed COPD development by inactivating JAK2/STAT3 signaling
COPD
COPD, COLLAPSE, CAVITY, INFLAMMATORY CELL INFILTRATION
To further confirm the biological roles of SOCS5/JAK2/STAT3 signaling in COPD, we established COPD mouse model. H&E staining showed that the pulmonary parenchymal inflammatory cell infiltration, small airway thickening and alveolar cavity collapse were increased in the CS + pc-NC group compared to Air + pc-NC group, while this effect was alleviated by SOCS5 overexpression (Fig. 
SOCS5 suppressed COPD development by inactivating JAK2/STAT3 signaling. C57BL/6 male mice were randomly divided into Air + pc-NC group, CS + pc-NC group and CS + pc-SOCS5 group (n = 6/per group). 