Introduction
tooth loss, Periodontitis
PERIODONTITIS, PERIODONTAL DISEASES, INFLAMMATORY DISEASE, PERIODONTITIS
Periodontitis is an inflammatory disease that leads to the destruction of dental supporting tissues and tooth loss [Given the complex processes created by different pro-inflammatory and anti-inflammatory mediators, studies have investigated different strategies for regulating immune-inflammatory responses to periodontal diseases. Previous studies have shown that both non-steroid anti-inflammatory drugs (NSAIDs) and selective COX-2 inhibitors regulate the host immune-inflammatory activities [Antibiotics have been widely used for treating periodontal diseases; however, using them frequently contributes to antibiotic resistance [To date, different surgical and non-surgical treatments have been used for periodontitis; however, few drugs are available for the treatment of periodontitis. Herbal medicines have been used adjunctive to treat inflammatory diseases and recently to treat and prevent periodontitis, too [