Primary outcomes
fever, cholangitis
SECONDARY, CHOLANGITIS
In many centers, MEPM is a standard treatment for patients with moderate to severe post-KPE cholangitisThe baseline characteristic of patients treated with MEPM for mild, moderate, and severe cholangitis.AFC, age at first cholangitis; ALT, alanine aminotransferase; AST, aspartate aminotransferase; DBL, direct bilirubin; IQR, interquartile range; KPE, Kasai portoenterostomy; MEPM, Meropenem; T, temperature; WBC, white blood cell; CRP, C-reactive protein; γ-GT, gamma-glutamyl transferase.Median age was compared using Mann–Whitney test; Age at operation and DBIL were compared using independent samples Therapeutic effect of MEPM for mild, moderate and severe cholangitis.DOF, duration of fever; IQR, interquartile range; KPE, Kasai portoenterostomy; LOS, length of hospital stay.DOF, positive blood culture rates and LOS were compared between the three groups using Kruskal–Wallis test.The mean difference of the primary and secondary outcomes was compared using One-Way ANOVA.To reduce the use of carbapenems, antibiotics with lower bacterial coverage, such as CSTS, may provide similar results in the treatment of mild cholangitis. To test this hypothesis, patients with mild cholangitis were randomized to receive either CSTS or MEPM. We found that the DOF of patients who received CSTS was 30.00 (IQR: 24.00–36.00) h, which was not different from that of patients who received MEPM 28.00 (IQR: 24.00–40.00) h (Primary and secondary outcomes.DOF, duration of fever; IQR, interquartile range; LOS, length of hospital stay.DOF and LOS were compared using independent samples To shorten the duration of antibiotic treatment, an effective adjunctive treatment may be needed in patients with severe cholangitis