Background
NAFLD, NASH, noncirrhotic NASH, fibrosis
NONALCOHOLIC FATTY LIVER DISEASE, FIBROSIS
Nonalcoholic fatty liver disease (NAFLD) is a global health challenge with detrimental impacts on mortality, morbidity, and health care resource utilization [Despite the potential for PROs to capture the broader impact of NASH, standardized, disease-specific measures for evaluating patients’ experiences with NASH have been either limited or not developed in accordance with key regulatory guidance for PRO measures [The initial development of NASH-CHECK included qualitative research conducted with patients with noncirrhotic NASH (fibrosis [F] levels F1 through F3) in the United States [The objective of this study was to conduct a psychometric evaluation of NASH-CHECK to confirm the optimal scale structure for the measure and to evaluate the psychometric properties (reliability, construct validity, and responsiveness) of the identified scales.