2.3. Neutralizing Antibodies to DaxibotulinumtoxinA
ADVERSE EVENTS
Serum samples from subjects with a confirmed positive result for anti-daxibotulinumtoxinA binding antibodies were assessed for the presence of neutralizing antibodies using the validated mouse protection assay. No subject with treatment-related anti-daxibotulinumtoxinA binding antibodies tested positive for neutralizing antibodies. One subject had neutralizing antibodies at baseline and a consistent titer at additional timepoints after a single treatment, which was categorized as a treatment-unaffected antibody response. This subject, whose last exposure to prior botulinum toxin was approximately 32 months prior to study enrollment, had no clinical response to DAXI and did not report any adverse events (AEs).