Discussion
overdose
ADVERSE EVENTS, DISORDER
This cohort study used data from the first, to our knowledge, prospective trialLimitations include possible undetected fentanyl analogues or nitazenes leading to PW. We may have missed PW after discharge, although follow-up rates at 7 days after the ED visit were 86% and likely would be captured as adverse events.In this geographically diverse observational cohort, buprenorphine induction in the ED remained safe and effective, even with fentanyl present. Continued access to buprenorphine for opioid use disorder treatment is essential given the ongoing overdose crisis.