INTRODUCTION
DISEASE, CORTEX
UP165, a standardized Current Centers for Disease Control and PreventionWhile there are some psychotropic clinical and anecdotal data available to support the usage of sedative and anxiolytic plants like kava kava, Cortisol, a glucocorticoid released from the adrenal cortex, is more than a stress hormone known to regulate multiple vital metabolic and physiological functions in the body through the hypothalamic-pituitary-adrenal (HPA) axis. Sleep is among several physiologic functions regulated by HPA axis,In a similar study, compared with healthy young subjects (average of 21 years old), healthy older adults (average of 71 years old) were found to sleep more poorly at night, as indicated by increased wake time and decreased percentage of slow-wave sleep. Similarly, interaction between altered HPA-axis functions and disturbed sleep was underlined by studies indicating a positive correlation between total wake time and 24-hour urinary cortisol secretionPreviously, the mood-enhancing effect of UP165, a These clinically meaningful desired outcomes were postulated partially as a result of the mechanisms of action of UP165 such as (1) structural similarity of the active in UP165 to that of melatonin and the production of a melatonin-like effect, (2) increased endogenous biosynthesis of serotonin and melatonin through induction of rate-limiting enzymes, such as tryptophan-5-hydroxylase, and 