Study drug and administration
The study drug was provided in the form of granulated cannabis inflorescence by Bedrocan BV (Netherlands) produced in accordance with Good Manufacturing Practice and confirms to the European Medicines Agency’s contaminant levels for products used in the respiratory tract. Each cannabis dose consisted of 10 mg of THC (two standard THC units [Cannabis preparations were administered using a Volcano® Medic Vaporiser (Storz-Bickel GmbH, Tüttlingen, Germany). Each preparation was vaporised at 210 °C into a transparent polythene bag. This temperature has been found to maximise cannabinoid delivery [