Sample size and statistical analysis
REGRESSION
Based on the exploratory nature of study, the planned number of patients was 20 without a formal statistical power calculation. Summary statistics were reported as number of subjects, frequency with percentage for categorical data, and median or mean ± standard deviations for continuous variables. The incidence rate ratios (IRR) with 95% confidence interval for the number of AF episodes recorded during ECG-Holter monitoring (pre-treatment and 1, 3, 6, and 12 months post-treatment) were calculated using a Poisson regression mixed model with patient as random effect. A 