Background and Rationale
cancers, weight loss, post-menopausal breast cancers
CANCERS, CARDIOVASCULAR DISEASE, OVERWEIGHT AND OBESITY, TYPE 2 DIABETES, DISEASES
Overweight and obesity are associated with an increased risk of several non-communicable diseases such as type 2 diabetes, cardiovascular disease, and some cancers (for example, bowel and post-menopausal breast cancers) [Inequalities in health outcomes and processes (such as intervention uptake and adherence) are known to occur across many measures summarised by the PROGRESS-Plus criteria − place of residence, race/ethnicity, occupation, gender/sex, education, socioeconomic status (SES), social capital, plus other factors for which discrimination could occur such as age and sexual orientation [We have previously conducted a systematic review that considered inequalities in the uptake of, adherence to, and effectiveness of behavioural weight management interventions [The Weight Loss Referrals for Adults in Primary Care (WRAP) trial has completed follow-up data collection at the 5-year time point, allowing for a rare opportunity to study inequalities in weight change following weight loss intervention over an extended time period. All participants in the WRAP trial received a behavioural weight loss intervention (brief intervention information booklet or vouchers for 12- or 52-weeks of WW (formerly WeightWatchers)). Previous analyses of this trial have found that trial uptake (the number of invited vs. recruited participants) was higher in older participants, people from less deprived areas, and women (although the proportion of males in WRAP was much higher than seen in similar trials or routine primary care referral) [