Study endpoints
death, fever
ASYMPTOMATIC COVID-19
The question of scientific interest that the trial was designed to assess was whether treatment with doxycycline reduces the need (indication) for ICU care in newly hospitalized patients with symptomatic COVID-19. Therefore, the primary endpoint was the need for transfer to ICU within 14 days of admission, as judged by the attending physicians. Secondary endpoints included in the study protocol were: death, mechanical ventilation, time to discharge, recovery from symptoms, resolution of fever, prolonged hospital stay (>7days), and supplemental oxygen required.