Abbreviations:
SKB
analysis of varianceSatisfaction With Facial Appearance Overalllight amplification by stimulated emission of radiationlight emitting diodeoptical coherence tomographyphotobiomodulationWrinkle Assessment ScaleEFB, JAP, MM, MBG, AFP, RAMF, SKB, LJM, and KPSF contributed equally to this work.Trial registration number: NCT04911140.EFB received a grant from Higher Education Personnel Improvement Coordination - CAPES (88887.481244/2020-00), KPSF from National Council for Scientific and Technological Development (CNPq - 304330/2020-5), SKB from CNPq- National Council for Technological and Scientific Development (CNPq, n.306577/2020-8) and RAMF from CNPq- National Council for Technological and Scientific Development (CNPq, n n.310491/2021-5). Cosmedical (Brazil) kindly provided the LED device.This protocol was approved by the Research Ethics Committee of Nove de Julho University (acceptance number: 4.365.565). The trial has already been registered in the ClinicalTrials.gov PRS (ID: NCT04911140) and it grants public access to the full protocol. After publishing the protocol, the data will be collected and the results will be presented at conferences and published in a peer-reviewed journal, selected by interest area and impact factor. At the end of the study, the main results will be disseminated to participants by email. The authorship of the results paper will include the authors of the protocol and others who may contribute to the procedures or analysis of data.The authors have no conflicts of interest to disclose.Data sharing not applicable to this article as no datasets were generated or analyzed during the current study.How to cite this article: Bragato EF, Pires JA, Momolli M, Guerra MB, Paisano AF, Ferrari RAM, Bussadori SK, Motta LJ, Fernandes KPS. Comparison of the effects of 2 frequencies of application of photobiomodulation on facial rejuvenation: Controlled, randomized, and double-blind clinical trial. 