Abstract
pemphigus, Pemphigus Vulgaris, myotoxic, autoimmune disease, muscle wasting
ADVERSE EFFECT, PEMPHIGUS, MAY, PEMPHIGUS VULGARIS, AUTOIMMUNE DISEASE, MUSCLE WASTING
Pemphigus Vulgaris (PV) is a blistering autoimmune disease caused by autoantibodies against desmoglein 1 and 3. Treatment options are limited to corticosteroids and immunosuppressants. The myotoxic effect of glucocorticoids is a fact that has been elucidated. So, the development of efficacious treatment approaches to combat muscle wasting is of great importance. Considering the adverse effect of glucocorticoid therapy in pemphigus patients and altered muscle metabolism, this study aimed to investigate the effect of Glucocorticoids adverse the normal muscle metabolism and leads to protein breakdown and muscleatrophy through various pathways and L‐carnitine downregulates the muscle catabolism pathways,leads to protein anabolism and muscle growth.
[Correction added on 25 May 2023, after first online publication: Author's spelling is corrected from Mahmood Jalili to Mahmood Jalali in this version]