Treatment plan
toxicity
The original-dose CapeOX treatment comprised capecitabine (1,000 mg/mFive patients were unable to complete the initial two courses of chemotherapy due to toxicity, necessitating dose reduction (10/15) or suspension of the subsequent course (12/15). Considering these results, the IDMC recommended continuing the study with a reduced-dose CapeOX treatment comprising capecitabine (750 mg/m