Safety and adverse events
fatigue, diarrhea, toxicity, thrombocytopenia, vomiting, abdominal distension, rashes
ADVERSE EVENT, DISEASE, THROMBOCYTOPENIA, LOSS OF APPETITE, EVENTS, GASTROINTESTINAL DISORDERS
The most frequently observed toxicity events were grades 1 and 2 gastrointestinal disorders, incidences of rashes, thrombocytopenia and fatigue, followed by loss of appetite, abdominal distension, vomiting, and banded blister disease, which occurred mainly in the first three cycles. The incidence rates of grades 3 and 4 AEs in the ICd and Id groups were 21.1% and 23.5%, respectively. In the ICd group, one patient developed grade 3 thrombocytopenia, and three patients developed severe digestive AEs (two patients exhibited diarrhea, another exhibited vomiting accompanied by abdominal distension). In the Id group, one patient had abdominal distension, one exhibited vomiting and two had diarrhea (Table Adverse events in the ICd and Id groups

