Outcomes
liver injury, postoperative serious adverse events, postoperative liver injury
ONCOLOGY, ADVERSE EVENT, SECONDARY
The primary outcome was the peak level of aspartate aminotransaminase (AST) during three postoperative days (POD), representing postoperative liver injury.The secondary outcomes, measured during three POD, were peak alanine aminotransaminase (ALT) levels to measure liver injury and total bilirubin (tBil) to measure liver function. Another secondary outcome included postoperative serious adverse events (SAE) occurring within 28 POD. SAE was defined as Grades 3a, 3b, 4a, 4b, and 5 according to the Common Terminology Criteria for Adverse Events, version 4.0, of the Japan Clinical Oncology Group. A previous study at NCCH confirmed that AST, ALT, and tBil peaked within three POD [