References
atherosclerosis
CVD, ATHEROSCLEROSIS

Thank you for your comments,
In our sample size calculation, we assume that the effect size is 0.1 with a standard deviation of 0.12. With the plan to use of 2 sample t-test, the sample size needed for 90% power and 5% significant level is 32 per arm. Assuming an additional 20% drop in each arm (placebo and control group), we need a minimum of 40 participants.We exclude subjects >45 years because the highest PLHIV prevalence in Indonesia is 20-45 years and we want to see the effect of atorvastatin on subclinical atherosclerosis in virally-suppressed HIV-infected patients with CMV seropositivity. A previous study reported that CVD morbidity and mortality in PLHIV is higher above 45 years old than in negative controls.
 Reference: Chastain DB, Stover KR, Riche DM. Evidence-based review of statin use in patients with HIV on antiretroviral therapy. J Clin Transl Endocrinol. 2017 Feb 22;8:6-14. Thank you and best regards, Evy