2.4.3. Statistical analysis.
SECONDARY
Primary outcome was the difference of s-IgA in saliva from start to end of the study (16 weeks after the start). Secondary outcomes were increase in s-IgA in saliva from the start to 4, 8, and 12 weeks after the start, increase in JCP-specific IgE in serum, each POMS2 score and the score of nasal symptoms 4, 8, 12, and 16 weeks after the start. Further secondary outcomes were increase in organic anions and fatty acid levels and the abundance ratio of each bacterium in fecal samples from the start to the end. The score of nasal symptoms and the abundance ratio of each bacterium in fecal samples were analyzed with Wilcoxon test, and other evaluated items were analyzed with Student To examine whether Data were analyzed using SAS 9.4 software (SAS Institute, Cary, NC) for primary and secondary outcomes and JMP Pro 14.1.0 software (SAS Institute) for post hoc analysis.