Ethics
This is a post-hoc analysis of the ALL-IN trial that received ethical approval of the Medical Ethics Committee of the University Medical Center Utrecht, Utrecht University. In the ALL-IN trial, all eligible patients from practices randomized to the intervention were informed on study purposes and asked for written informed consent before undergoing the intervention. The Medical Ethics Committee provided a waiver of informed consent for the collection of anonymized baseline and outcome data for all eligible patients in both arms, yet all strictly under the auspices of the treating GP. The authors had no access to information that could identify individual participants during or after data collection.