Patients
hematologic disease
HEMATOLOGIC DISEASE, RECRUITMENT, CORONARY ARTERY DISEASE
A total of 160 patients were enrolled over a 24-month period in a prospective, double-blind, single-center randomized controlled trial between March 2018 and February 2020. The Institutional Review Board (IRB) at our site approved the study prior to patient enrollment (Severance Hospital, South Korea, IRB number; 1-2017-0094). The study was performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. This study met the criteria of a primary registry of the WHO (ClinicalTrials.gov, NCT 04310150) before patient recruitment. Informed consent was obtained prior to the operative procedure. After explaining the randomized study of hemostatic agents, along with the procedure description, we obtained the patient’s consent. The inclusion criteria for enrollment eligibility specified patients aged 19 years or older who underwent elective OPCAB surgery for multivessel coronary artery disease. Patients were excluded if they were pregnant or had a known sensitivity to any components of the bovine thrombin preparations or to the porcine or bovine materials. Patients who were taking antithrombotic or antiplatelet agents for more than one week, except for aspirin, or who had a hematologic disease were also excluded from this study.