Exposure–response analysis
PK/PD
REGRESSION
Full details of the exposure–response analysis are provided in Additional file In the model including artefenomel exposure, the odds ratio of artefenomel AUCLogistic regression model for the exposure–response analysis for Day 28 PCR-adjusted ACPR. PK/PD efficacy populationThe final logistic regression model for the efficacy exposure–response analysis indicated that Day 28 PCR-adjusted ACPR could be described as a function of ferroquine AUCRepeating the primary analysis for Day 28 crude ACPR showed similar results, with no statistically significant contribution of artefenomel AUC