Introduction
PMP, high-grade tumors, Appendiceal adenocarcinoma, appendiceal tumors, heterogenous disease
CLINICAL SYNDROME, APPENDICEAL ADENOCARCINOMA, CAVITY, INFILTRATING, PSEUDOMYXOMA PERITONEI, HYPOCELLULAR
Appendiceal adenocarcinoma (AA) is both a rare and heterogenous disease, with marked contrast in the natural history of low-grade vs high-grade tumors (5-year overall survival [OS], 68% vs 7%).Histologically low-grade appendiceal tumors are generally hypocellular with abundant mucin and pushing, as opposed to infiltrating, margins.In nearly all patients, metastatic spread of AA is limited to the peritoneal cavity, causing the clinical syndrome pseudomyxoma peritonei (PMP).