Immune function and cytokine profiling
varicella zoster, VZV
VARICELLA ZOSTER, VIRUS
The immune-suppressive action of prednisolone was measured using the OX40 assay. Treatment with both placebo+prednisolone and AZD4017 + prednisolone decreased the percentage of CD25 + CD134 + cells following exposal to both varicella zoster virus (VZV) and phytohemagglutinin (PHA) in the OX40 assay. Whilst there was no significant difference in response to VZV exposure when comparing the two arms of the study (−0.40 [IQR −0.55 to −0.10] vs. −0.30 [IQR −1.85–0.00], 