Results
Of 782 patients screened for eligibility, 663 (median [IQR] age, 48 [36-57] years; 355 [53.8%] female and 305 [46.2%] male; median [IQR] BMI, 23.2 [21.3-25.0]) were randomized. During the study, 1 patient in the esketamine group had missing data on blood pressure, and 2 patients in the placebo group withdrew their consent. Those 3 patients were the only ones with missing data on the primary outcome. Ultimately, data from 660 patients (331 in the esketamine group and 329 in the placebo group) were included and analyzed (