Fatigue Perception
fatigue, Fatigue
The primary endpoint was the change in self-reported fatigue perception assessed by using the validated Fatigue Impact Scale (FIS-40) questionnaire from the baseline to the final (week 36) study visit. Briefly, the FIS-40 comprises 40 items divided into three domains that describe how perceived fatigue impacts on cognitive (10 items), physical (10 items), and psychosocial functioning (20 items) over the previous four weeks. Each item is scored from 0 (no fatigue) to 4 (severe fatigue). The total score is calculated by adding together responses from the 40 questions (score range 0–160). Higher scores indicate more functional limitations due to severe fatigue [