Statistical analysis
The data were analyzed by SPSS 22.0 software (IBM Corporation, USA). The general count data of the four groups were compared by one-way ANOVA. VAS, IL-6, PT/BW, and WF were all continuous variables, and the analysis of student residuals and Shapiro Wilk test accorded with the test hypothesis. Therefore, the repeated measures analysis of variance method was used to statistically analyze the data in each group before and immediately after modeling, 24 h, 48 h, and 72 h, and evaluate the time and interaction between groups, as well as the main utility of time and groups. After Mauchly's spherical test of the data, the results that do not meet the spherical hypothesis were corrected by epsilon. When the intervention measures interact with time factors, the separate effects of time and groups need to be analyzed respectively; The group independent effect was compared with the index differences between the groups at five different time points by multivariate analysis of variance, and the case of uneven variance after Levene's homogeneity test was analyzed by Welch analysis of variance; Single-factor repeated measures analysis of variance was used to analyze the differences of time factors in different groups, and Bonferroni method was used for pairwise comparison. When there is no interaction between intervention measures and time factors, the main effects of time and groups need to be analyzed and further compared. The significance level was 