Study design
BLIND
The study design was an investigator-initiated, prospective, single-blinded, randomized controlled trial. Due to the particularity of intervention measures, it was not feasible to blind the intervener, therefore, only the evaluator remained blinded. The study was registered at Chictr.org in February 2022. (Chinese Clinical Trial Registry Unique Identifier ChiCTR2200056768, registration time 15/02/2022), and received approval from the Clinical Medical Research Ethics Committee of The Third Affiliated Hospital of Sun Yat-Sen University. The study began in January 2021 and concluded in January 2022.