Statistical analysis
diabetes
CARDIOVASCULAR DISEASE, SENSITIVITY, CHRONIC RESPIRATORY DISEASE, REGRESSION, DIABETES
For seroconversion analysis, 850 (99.3%) participants had a pre-vaccination plasma sample available for analysis. Differences in proportion were determined using the z-test for independent proportions.For assessment of antibody concentrations, values below the lower limit of detection/extrapolation were assigned a value of half of the lowest detected/extrapolated value, values above the upper limit of detection/extrapolation were assigned a value of 1.5 times the highest detected/extrapolated value. Differences between COVID-19 vaccines were assessed using linear regression of log-transformed antibody data adjusted for region (Mato Grosso do Sul/Rio de Janeiro/Amazonas), age (<40 years; 40 to 59 years; ≥60 years), sex (male/female), presence of cardiovascular disease, diabetes, chronic respiratory disease, workplace COVID-19 direct contact at baseline (yes/no), SARS-CoV-2 PCR result at baseline (detected/not detected/not performed). Differences between randomisation groups were assessed using linear regression of log-transformed antibody data. Sensitivity analysis for differences between BCG- and placebo-vaccinated participants was done adjusting for time between most recent COVID-19 vaccination and blood collection (continuous), age (<40 years; 40 to 59 years; ≥60 years), sex (male/female) and region (Mato Grosso do Sul; Rio de Janeiro; Amazonas). Data analysis was done using Stata version 17.0 (StataCorp LLC, USA)The authors declare that the data supporting the findings of this study are available within the paper and its supplementary information files.