Study population
CRC
A total of 4392 primary stage II/III CRC patients confirmed by pathological diagnosis were enrolled in this retrospective cohort. These patients underwent radical resection surgery in the Third Affiliated Hospital of Harbin Medical University from January 2007 to December 2013. Patients who met one or more of the following exclusion criteria were excluded (Fig. Detailed flow chart of patient selection in this studyAt last, 4014 stage II/III CRC patients were included in this study and these patients were randomly divided into a training set (60%) and a testing set (40%). Throughout this article, the term ‘‘prognostic marker’’ is defined according to REMARK Guidelines [