2.5. Statistics
cognitive and mood, fatigue
All cognitive and mood outcome measures were modelled using the MIXED procedure in SPSS (version 26.0, IBM Corp., Armonk, NY, USA). For the episodic memory outcomes, the post dose data were modelled including treatment as a fixed effect. For the CDB task and VAS outcomes, changes from baseline values were modelled with treatment, minutes post dose (60, 120), repetition (1–4), and their interactions as fixed effects and participant as a random effect. For the psychological state and mood scales, changes from baseline data were modelled with treatment, minutes post dose (60, 120), and their interaction as fixed effects and participant as a random effect. Pairwise comparisons were all specified a priori and carried out using Sidak corrections. The a priori comparisons of 100 mg and 300 mg coffeeberry against placebo at 120 min post dose on the mental fatigue and alertness scales were specified as primary endpoints.