Discussion
NAFLD, death, fatty liver disease, hepatic and extrahepatic complications, progression/regression, cirrhosis, fibrosis, NASH, HCC, decreased intrahepatic fat, hepatic inflammation, non-obese, weight loss
OBESE, DISEASE, CIRRHOSIS, FIBROSIS, REGRESSION
NASH can progress to cirrhosis, HCC, and death and is an increasing indication for liver transplantation [ICR, as a novel dietary approach in the treatment of NAFLD, has the two most common strategies of strict alternate-day fasting and a 5:2 diet with two self-selected days with extreme energy restriction and 5 days without calorie restriction [Despite these promising findings, further studies are required to address the multiple areas of uncertainty. It remains to be elucidated whether ICR is superior to CCR at similar amounts of net energy intake with respect to a broader set of metabolic health indicators [On considering the disease burden, including hepatic and extrahepatic complications, preventive therapies to inhibit the progression of fatty liver disease to NASH are required [Previous studies have shown decreased intrahepatic fat content with weight loss of > 5–7% and improvement of hepatic inflammation and fibrosis with weight loss of > 7–10% in obese NAFLD patients [Finally, evaluating the regression or progression of NAFLD with histology would be ideal, especially in 22 terms of diagnosis of NASH and assessment of progression/regression of NASH and/or fibrosis. Because this study is not a novel drug trial, performing a liver biopsy in the entire study participants might not be justified given that the treatments in the study are two forms of dietary intervention. In addition, the downsides of liver biopsy, such as invasiveness, costs, sampling error, and interobserver variability, were considered [In conclusion, this FLICR study may provide clinical evidence for ICR in the treatment of NAFLD in both obese and non-obese patients. The use of ICR in patients with NAFLD will improve the clinical outcomes of patients facing a shortage of effective medical therapy.