Subjective drug effects and effect durations
DRUG EFFECT
Subjective effects were assessed repeatedly using visual analog scales (VASs) [The time to onset, time to maximal effect, time to offset, and effect duration were assessed in Phoenix WinNonlin 8.3 (Certara, Princeton, NJ, USA) using the “any drug effect” VAS effect-time plots and an onset/offset threshold of 10% of the maximum individual response as described previously in detail [