Introduction
stroke, hemorrhage
STROKE, FRAGILITY, SECONDARY, HEMORRHAGE, EVENTS, EVENTS
Aspirin is an antiplatelet agent that has been used in low doses (75-100 mg/d) for the prevention of cardiovascular events. Despite some recent unfavorable findings, it continues to be widely used for primary and secondary prevention of stroke.Information about the efficacy of low-dose aspirin in the primary prevention of stroke is derived from meta-analyses and results of recent major trials, most of which have been conducted in populations with mean ages younger than 70 years.Clinical characteristics of older individuals include an increased inherent susceptibility to hemorrhage, which may be associated with increased fragility of small blood vessels.The Aspirin in Reducing Events in the Elderly (ASPREE) trial is the largest randomized controlled trial of low-dose aspirin focused on investigating the balance of risks and benefits of this therapy in an older age group.