Responsiveness
non-work-related activity impairment
Anchor-based responder analyses were performed to assess the ability to detect change in WPAI domain scores by responder status for each of the three anchors (MSQ-RFR, MSQ-RFP, and monthly migraine-headache days). The least square mean changes from baseline to Month 3 for WPAI for both responders and non-responders for each of the anchor variables was estimated and compared. Statistically significant differences (Analysis of covariance (ANCOVA) models were utilized to examine differences in the change in WPAI domain scores from baseline to Month 3 among patients in all the anchor-based responder groups; the assessment evaluates the past 7-days at both time points. The change in WPAI presenteeism, overall productivity loss, and non-work-related activity impairment was the dependent variable, while the responder group variable was included as the independent variable in the model. Baseline WPAI presenteeism, overall productivity loss, and non-work-related activity impairment was adjusted for the respective models.