Clonotypic dynamics of ITCs were hallmark of responders
tumors
TUMORS
Of note, paired ITC analyses of baseline and resected tumors from individual patients revealed that clonotypic dynamics (clonally expanded and contracted ITCs) were a hallmark of responsive patients. These dynamic shifts in intratumoral TCRs were reflective of clinical outcomes, in that more significantly clonal expanded and contracted ITCs were observed in well responders compared with poor responders (Fig. 