Efficacy
glioblastoma, ovarian cancer
GLIOBLASTOMA, DISEASE, OVARIAN CANCER, DISEASE PROGRESSION
In the glioblastoma cohort, one patient had a confirmed partial response with a steady decrease in target lesion size to less than 10% over a treatment period of 16 cycles (see Online Resource 1). Another patient with stable disease as best response was treated for 10 cycles, corresponding to a disease control rate of 2/8 (25%) after eight cycles of treatment, and an objective response rate of 1/8 (12.5%) in the EEP of this cohort. In the ovarian cancer cohort, the best response was stable disease in three patients, corresponding to disease control rates of 3/8 (37.5%) after two cycles of treatment in the EEP. After four cycles, the disease control rate was 1/8 (12.5%) in the EEP. Reduction in the size of target lesions was observed in four patients with ovarian cancer and in three patients with glioblastoma.All study patients experienced disease progression. The six-month PFS rates in the ovarian cancer and glioblastoma cohorts were 9.1% and 16.7%, respectively. Kaplan-Meier curves for PFS are shown in Fig. 
Progression-free survival (full analysis population)