Author contributions
All authors critically reviewed drafts of the manuscript, had final approval of the version to be submitted and published, attest to the accuracy and integrity of the data, and agree to be accountable for all respective aspects of the work. AT and MS contributed to conception of this post hoc analysis. CCH designed the supportive analyses, contributed to analysis and interpretation of data, and developed the first draft of the manuscript. SW contributed to data analysis and figure preparation. AS performed machine learning to identifying lymphocyte subgroups, statistical analyses, and QC, KJ contributed to data analysis and performed QC of data sets. SK performed in vitro analyses. TH, AW-D, PL, and JS clinically reviewed the data and contributed to interpretation of data. TW, AT, MS, and J-LV were investigators of the phase II CIGMA trial and supported this post hoc analysis with clinical expertise and relevant discussions and interpretation of the data.