Introduction
disorder, CF, TNF-α, tumor necrosis, fatigue, autosomal recessive disorder, dyspnea, CF hospitalized, shoulder abductors, chronic pulmonary infection
DISORDER, TUMOR NECROSIS, BRONCHIECTASIS, EXOCRINE PANCREATIC INSUFFICIENCY, LUNG DISEASE, CYSTIC FIBROSIS, CYSTIC FIBROSIS, CYSTIC FIBROSIS (CF)
There is little information on pulmonary rehabilitation in patients with cystic fibrosis (CF) with pulmonary exacerbation. This study aimed to evaluate the effects of an early rehabilitation program on lung function, muscle strength, inflammatory markers, and quality of life in adults with CF hospitalized for pulmonary exacerbation. In this randomized controlled trial, 19 patients were included in the intervention group and 15 in the control group. The intervention group underwent an early rehabilitation program for 14 days after admission. All patients underwent spirometry, one-repetition maximum tests (1RM), and the 6-min walk test, and answered the Revised Cystic Fibrosis Questionnaire (CFQ-R) for quality of life and the International Physical Activity Questionnaire. Serum levels of interleukin and tumor necrosis factor alpha (TNF-α) were measured. In the intervention group, there were increases in 1RM biceps (P=0.009), triceps (P=0.005), shoulder abductors (P=0.002), shoulder flexors (P=0.004), hamstrings (P<0.001), and quadriceps values (P<0.001). In addition, there were improvements in CFQ-R-emotion (P=0.002), treatment burden (P=0.002), vitality (P=0.011), and physical scores (P=0.026), and a reduction in the Borg resting fatigue score (P=0.037). The interleukins levels did not change after the intervention. In adult CF patients with pulmonary exacerbation, early hospital rehabilitation had a significant impact on improving resting fatigue, muscle strength, and quality of life.Cystic fibrosis (CF) is a common autosomal recessive disorder among Caucasians caused by mutations in the gene that encodes the CF transmembrane conductance regulator. The disorder is characterized by chronic pulmonary infection, bronchiectasis, exocrine pancreatic insufficiency, and a high concentration of electrolytes in sweat (A combination of progressive limitations in physical fitness and increasing inactivity in CF patients leads to a vicious cycle in which dyspnea worsens and physical strength decreases, leading to severe quality of life (QoL) impairment (Regular exercise in CF patients improves cardiorespiratory capacity, reduces lung function decline (Regular exercise combined with standard therapy has resulted in improved mucociliary clearance, body composition, bone development, immune function (Pulmonary exacerbation is the leading cause of hospitalization in individuals with CF, and during hospitalization, their physical activity level, exercise tolerance, and muscle strength decrease (The main objective of this study was to evaluate the effects of an early rehabilitation program involving aerobic and muscle strength training in adult CF patients admitted to the Hospital de Clínicas de Porto Alegre (HCPA) due to exacerbation of lung disease.