Statistical analysis
Data were analyzed using GraphPad Prism Version 9.3.1 (GraphPad, La Jolla, CA). Continuous data are given as mean ± SD unless stated otherwise. Pairwise comparisons were performed with paired t-tests. A p-value below 0.05 was considered significant. The relation between TH values and HR was modelled using a logarithmic growth equation with a plateau: HR = Y