4. Discussion
PSCI, cognitive impairment, stroke, Post-stroke depression, depressive symptoms, headache, depressed mood, depression, Cognitive impairment
STROKE, COMPLICATIONS
Post-stroke depression, one of the most prevalent clinical complications of a stroke, poses a formidable obstacle for stroke survivors during rehabilitation. The primary objective of this study was to evaluate the synergistic effects of 4-week rTMS combined with 6-week MBSR for PSD patients. After the experimental protocol and throughout the 8-week follow-up, patients who received the combined treatment demonstrated significant improvements in depressed mood, cognitive function, activities of daily living, and sleep quality. In addition, there is tentative evidence of a possible association between cognitive function, activities of daily living, and sleep quality, and depressed mood. As far as we know, this is the first study to examine the efficacy of rTMS–MBSR therapies for recovering PSD patients.Regarding the primary objectives of our study, we discovered that following the intensive daily treatment, immediate and follow-up results indicated a significant improvement in depression status in PSD patients treated with rTMS–MBSR. It has been shown in other studies that mindfulness-based stress reduction combined with transcranial magnetic stimulation effectively enhances the comfort degree of psychology [The significant improvement in cognitive function is in line with that reported by Kim et al. [Our findings suggest that these processes mediate some of the effects of MBI and PSQI on PSD patients. rTMS and MBSR promote the recovery of ADL and are closely related to the improvement of cognitive function. Cognitive impairment in patients can lead to a decrease in ADL, and early cognitive function can even be used as an independent predictor of long-term functional recovery and ADL [Finally, the correlation analysis revealed that the HAMD-17 score was strongly negatively correlated with MMSE and MBI scores and positively correlated with PSCI scores. The prognosis of depression symptoms is affected by cognitive function analyzed at the baseline. A cognitive perspective for depression and Monitor and Acceptance Theory (MAT) suggest that depressive symptoms are associated with cognitive impairment and that improved cognitive function can alleviate negative mood and stress-related physical and mental problems [A meta-analysis indicated that the risk of headache was significantly higher in the rTMS group compared with the control group (OR, 3.53; 95% CI, 1.85–8.55; 