KD and EEG
The NIHON KOHDEN EEG-1200K was used to record the EEG in a quiet environment. The 21-channel-EEGs were recorded under typical circumstances (rest, hyperventilation, and photostimulation). Throughout the recording period, children were being studied while resting off with their eyes closed. The International 10–20 system was used to record EEG data from 19 scalp electrodes for 20 min using an average reference (MIZAR-sirius 33 Channels, EBNeuro).At FP1, F3, C3, P3, O1, F7, T3, T5, FP2, F4, C4, P4, O2, F8, T4, T6, Fz, Cz, and Pz, electrodes were placed. The EEG was digitized at 256 Hz with a time constant of 0.1 sec, a high-frequency filter of 70 Hz and a notch filter in each channel. Based on visual assessment, consecutive, 2-s-long epochs free of artifacts were chosen offline. The provided EEG software was used to perform a rapid Fourier transform on these 20 epochs. Mean-power spectra were gathered for every channel and frequency range in each subject. Six bands were utilized to divide the frequency ranges: Delta (0–4 Hz), Theta (4–8 Hz), Alpha (8–12 Hz), Beta-1 (12–18 Hz), Beta-2 (18–24 Hz), and Gamma (24–64) were the six bands used to separate the frequency ranges.By comparing EEG before and 1, 3 and 6 months after the KD therapy regarding the background rhythm in the occipital region under the awake and silent states and variations of interictal spike-wave index (SI), the effect of KD on EEG features was assessed. SI represented the mean of the spike discharge times during a second. In the calculation procedure, 100 s of the awake and quiet EEG findings (free of artifact fragments) were chosen, and SI = 