Sample size and statistical analysis
Descriptive statistics were used to analyse patient characteristics.Intention-to-treat linear mixed model analyses were performed for within-group and between-group differences at three timepoints—directly post-chemotherapy, post-intervention and 1-year post-intervention and were adjusted for baseline values. We calculated the standardized effect size (ES) by dividing the adjusted between-group mean difference of the measurement directly post-chemotherapy, post-intervention and 1-year post-intervention using the pooled T0 standard deviation. An ES < 0.2 was considered ‘no difference’, ES between 0.2 and 0.5 small difference, ES between 0.5 and 0.8 moderate difference and ES > 0.8 substantial difference (Cohen 