Patients
stroke, artery occlusions, acute ischemic strokes
STROKE, EVENTS, ARTERY OCCLUSIONS
Patients aged 18 years or older with acute ischemic strokes caused by anterior proximal artery occlusions (intracranial internal carotid artery or M1 segment of the middle cerebral artery) who could be treated with intravenous alteplase treatment within 4.5 hours of stroke onset were eligible for inclusion in the DEVT. Time of stroke onset was defined as when the patient was last known to be well. Detailed information about the inclusion and exclusion criteria were described in the protocol of the DEVT trial [Two trial investigators, blinded to treatment allocation, centrally assessed functional outcomes using the modified Rankin scale (mRS) scores and recorded the occurrence of medical events between follow-ups on the basis of video or voice recordings taken at the outpatient clinic, during a telephone or video call, or by the patient’s family. If video or voice recordings were unavailable, mRS scores were determined by trained interviewers who were unaware of initial information and was based on a standardized interview protocol, supplemented by medical record review. Disagreements were resolved by consensus. The patient or his or her primary caregiver were also be invited to complete the European Quality of Life 5-Dimension 5-level scale (EQ-5D-5L) questionnaire to assess quality of life [