Introduction
Thabit, neurological diseases, memory impairment
NEUROLOGICAL DISEASE, CORTEX
While the complete understanding of the At the cellular level, synaptic plasticity has been established as the basic mechanism of learning and memory. In 1949, Donald Hebb explained the synaptic dynamic regulation, emphasizing the importance of space and time in which neurons are activated [Non-invasive brain stimulation (NIBS) techniques such as Synchronization of cortex activation with the TMS pulse is needed to facilitate tract excitability; therefore, Thabit et al. (2010) activated the hand M1 cortex endogenously by asking participants to move their hand during a motor task [Recent TMS studies have reported improved cognitive processes, specifically memorization potentiation. These studies have mainly followed a repetitive TMS (rTMS) protocol (traditional or Theta Burst Stimulation) to induce functional enhancement in word-related memory [Here, we introduce a new protocol derived from task-related PAS methodology to enhance memorization capacity in humans. We hypothesized that the combined stimulation of TMS and endogenous hippocampal activation would enhanced WM task performance. Moreover, for the first time, we demonstrated the viability of directing TMS to the hippocampus and neuromodulation to improve WM using a combined-stimuli protocol. These findings may have important implications in the use of NIBS to treat neurological diseases that are affected by memory impairment.