2.4.6. Randomization
Randomization will be performed centrally based on a computer-generated randomization list (generated using R software (version 4.1.2)) and will be block randomization with variable block length. Allocation to the 3 groups will be in a 1:1:1 ratio. Randomization will be performed at the end of the inclusion examination by the study physician using an administrative database. This will happen after informing about the study, providing written informed consent, and reviewing the inclusion and exclusion criteria. The last name, first name, date of birth, and sex will be entered into the administrative database by the study physician. The system performs automated randomization, and randomization confirmation is generated and printed using a button click. All further personal data will then be completed by the study nurse. The result of the randomization is communicated to the patients when the baseline questionnaires have been completed. Subsequently, training in the respective interventions will take place.