Institutional Review Board Statement
This study was conducted in accordance with the Declaration of Helsinki. All participants were given an overview of the study and provided written informed consent. The study was approved by the Research Ethics Committees of Ritsumeikan University, Japan (BKC-IRB-2018-071, approved on 3 June 2019), and Ajinomoto Co. Inc (2018-013, approved on 1 November 2018) and adhered to the tenets of the Declaration of Helsinki. It was registered in the University Hospital Medical Information Network Clinical Trials Registry (UMIN000037306) on 8 July 2019.