Conclusions
SSNS
Impaired HRQoL was more profound in older children with first onset SSNS, in whom considerable proportions of impaired physical, emotional and total functioning were observed. Furthermore, this study showed that HRQoL and EBD are already affected in the first weeks after onset. Therefore, systematically monitoring of HRQoL and EBD by the use of PROMs should be encouraged to improve patient-centered care and timely identify signs of impaired HRQoL and EBD in children with first onset SSNS. Collection of longitudinal data of the first 2 years after onset is still ongoing and will provide additional insight into predictors of HRQoL outcomes eventually.