1. Introduction
lower urinary tract symptoms, fatigue, urinary disorders, AMS, climacteric syndrome, dysuria, PH, Prostate, nocturia, voiding dysfunction
CLIMACTERIC SYNDROME, NOCTURIA, PROSTATIC HYPERPLASIA, PROSTATE, INTERMITTENT URINARY INCONTINENCE
These authors contributed equally to this work.Male climacteric syndrome (MCS) is a medical condition that can affect middle-aged men whose testosterone levels begin to decline considerably. These symptoms may include fatigue, decreased libido, mood swings, and disturbed sleep. MCS can be managed with lifestyle modifications and testosterone replacement. However, testosterone therapy may cause number of side effects, including an increased risk of cardiovascular issues. This study aims to evaluate the efficacy and safety of unripe black raspberry extract (BRE) against MCS and voiding dysfunction in men with andropause symptoms. A total of 30 subjects were enrolled and randomly assigned to the BRE group (n = 15) or the placebo group (n = 15). Participants were supplemented with 4800 mg BRE or placebo twice daily for 12 weeks. The impact of BRE was assessed using the Aging Male’s Symptoms (AMS scale), International Prostate Symptom Score (IPSS) and the IPSS quality of life index (IPSS-QoL). Additionally, male sex hormones, lipid profiles, and anthropometric indices were assessed 6 and 12 weeks after treatment. The AMS scores did not differ significantly between the two groups. In the BRE group, the total IPSS and IPSS-QoL scores decreased significantly after 12 weeks compared to baseline (Men are prone to chronic conditions such as aging males’ symptoms (AMS) and prostatic hyperplasia (PH), which can lead to urinary disorders such as lower urinary tract symptoms (LUTS), including intermittent urinary incontinence, dysuria, urgency, and nocturia and can negatively impact quality of life [