Change in exercise capacity, respiratory and peripheral muscle strength and health status
IPF
SECONDARY
The change in outcomes from baseline at all assessment points are shown in Average predictions for main outcomes values at the main time points during the trial and for changes from baseline (actual and adjusted for age)6.3515.64376 2.95HIIT, high-intensity interval training; MICT, moderate-intensity continuous training; 6MWD, 6 min walk distance; QUADS-DOM, quadriceps strength; SGRQ-I, St George’s Respiratory Questionnaire for IPF; SNIP, sniff nasal pressure.Change from baseline in four key outcomes by intervention group over time. 6MWD, 6 min walk distance; HIIT, high-intensity interval training; MICT, moderate-intensity continuous training; SNIP, Sniff nasal pressure.Age-related variations in the four key outcomes (6MWD, SNIP, QUADS-DOM (quadriceps strength) and SGRQ-I total score) per training group using random effects models. The vertical line indicates the inflection point (ie, highest or lowest values) in each age group. The ages are the mean values in each tertile. 6MWD, 6 min walk distance; HIIT, high-intensity interval training; MICT, moderate-intensity continuous training; SGRQ-I, St George’s Respiratory Questionnaire for IPF; SNIP, sniff nasal pressure.The quadratic term was significant for all secondary outcomes (p=0.0014 for SNIP, p=0.004 for QUADS-DOM and p=0.0014 for SGRQ-I) (SNIP values peaked earlier than 6MWD values in both groups by approximately 2 weeks (There was no evidence for a difference between treatment groups for the SGRQ-I values. The time to reaching the greatest improvement in SGRQ-I score was shorter in the HIIT group, but the changes in the HIIT group were of smaller magnitude at all time-points (

