Discussion
obesity, diabetes
OBESITY, HYPERTENSION, DIABETES
The primary objective of this study was to evaluate the safety and tolerability of single dose of JMB2002 by intravenous infusion in healthy participants. The incidence of drug-related TEAEs at 50 mg/kg dose level was higher than that at other dose levels, suggesting that increased JMB2002 may increase the safety risk. Nevertheless, it remained tolerable in all the participants, with only 1 grade 2 and no grade ≥ 3 or worser TEAEs.Our results are comparable to similar drugs reported in previous literatures. In a phase I clinical study, Etesevimab (also known as CB6, JS016, LY3832479, or LY-CoV016), a recombinant neutralizing human IgG1 monoclonal antibody developed by Top Alliance Biosciences in China, triggered 173 TEAEs in all 40 (100%) participants and 22 drug-related TEAEs in 17 (42.5%) participants [The pharmacokinetic parameters CIn contrast to many NAbs showing low affinity or efficacy to the most recent Omicron variant [There are several limitations in this study. First, as a phase 1 clinical trial, the sample size is small. Second, participants were recruited from healthy Chinese adults aged 21–45 years old. It remains undetermined whether JMB2002 is safe for high-risk population, such as older adults and those with underlying comorbidities including but not limit to hypertension, diabetes, or obesity [