Introduction
OA, synovitis, osteoarthritis, KOA, bone impairment, Knee osteoarthritis
SYNOVITIS, OSTEOARTHRITIS, KNEE OSTEOARTHRITIS
Knee osteoarthritis (KOA), one of the most common types of osteoarthritis (OA), is mainly characterized by cartilage and subchondral bone impairment. In addition, meniscus and ligament injuries and synovitis could be associated [Mesenchymal stromal cells (MSCs)-based therapies have been considered as a therapeutic modality for KOA in numerous preclinical [Among different sources of MSCs, adipose tissue is the mostly regarded in the last decade. Adipose tissue-derived mesenchymal stromal cells (AD-MSCs) are abundance, accessible, and due to their uncomplicated isolation procedure, and maintaining enhanced differentiation capacity for more extended time they have being applied in many clinical studies [Accustomed monitoring methods for following the effect of MSCs transplantation in KOA are usually limited to imaging-based methods [In this study, following our previous pilot study which evaluated the clinical and laboratory findings of AD-MSCs transplantation in KOA [