Alterations in White matter
A robust interaction between session (baseline, post-treatment, 30-day follow-up) and drug on FA in the right UNC (post-treatment interaction coefficient: −0.01, 95% HDI [−0.02, −0.002]; follow-up interaction coefficient: −0.01, 95% HDI [−0.013,−0.003]), suggests a differential response to drug across sessions. In order to investigate the interaction, each session was analyzed separately. Ketamine showed a robust reduction in FA in the right UNC compared with midazolam group that lasts for at least 30 days (post-treatment: −0.011, 95% HDI [−0.018,−0.003]; follow-up: −0.018, 95% HDI [−0.027,−0.01]). Figure 