2.6.1. TPS Procedures
CORTEX
The TPS system consists of a mobile single transducer and an infrared camera system which incorporates neuro-navigation. This system was developed by NEUROLITH, Storz Medical AG, Tägerwilen, Switzerland. In addition, this TPS system can generate single ultrashort (3 µs) ultrasound pulses with 0.2–0.25 energy levels (mJ/mmThe interventionist used the TPS handpiece over the participants’ skull, such that the participants’ fMRI T1 brain images could be visualized and projected in real-time. The TPS treatment was performed by a licensed mental health professional holding the applicator at hand. Each TPS session was recorded for the purposes of post-TPS evaluation of intracerebral pulse localizations (In this trial, we targeted the stimulation to the left dorsal lateral prefrontal cortex (DLPFC), guided by a real-time MRI brain imaging. The basis for the choice of the selected brain region was based on previous research [