MS and NTs recruit similar regions in response to All Positive Feedback and All Negative Feedback
fatigue, Fatigue
CORTEX, EVENTS, MULTIPLE SCLEROSIS, POSITIVE
In response to All Positive Feedback, both MS and NT participants recruited the amygdala (right for MS and bilateral for NT), bilateral hippocampus, and occipital regions, relative to baseline levels of activity (In response to All Negative Feedback, we observed activation in the bilateral insula, right medial temporal gyrus (MTG), right vmPFC, and right orbitofrontal cortex (OFC) for MS participants. NT participants displayed activation in the right insula and in the left occipital pole (In both groups, significant clusters of activation in response to state fatigue emerged within the left temporal occipital fusiform cortex and left occipital fusiform gyrus during All Positive Feedback and within the left postcentral gyrus during All Negative Feedback (Activation Clusters and Local Maxima for Effects of State Fatigue.Peak intensities within each cluster with z values exceeding the cluster-defining threshold of 3.1 (p <.001, corrected to p <.017) for each event/contrast of events. Each unique cluster identified within the event/contrast is numerically listed in the “Cluster Number” column. When multiple peaks were identified within the same region, the reported coordinates correspond to peak activation with the highest z value. The Harvard-Oxford and Montreal Neurological Institute (MNI) Structural Atlases were used for the identification of anatomical brain region labels. MS = multiple sclerosis, NT = neurotypical, L = left hemisphere, R = right hemisphere.