Statistical analysis
We present data as median (interquartile range—IQR) or count (proportion) as appropriate. We compared categorical variables across the treatment groups with the use of the Cochrane-Mantel-Haenszel Chi-squared test stratified by the four study hospitals. We assessed continuous outcomes using the VanElteren test, accounting for clustering by study hospital. All data was analyzed using the intention-to-treat principle. Subgroup analyses presented herein were pre-specified (study protocol in supplemental material). Due to the interim analysis, the two-sided We determined whether observed clinical effects were driven by cessation of target agents by performing mediation analyses treating cessation of the MOI as a binary mediatorAll statistical tests were performed in Stata version 15 (College Station, TX), SAS v9.4 (Cary, NC), and R v4.0.1 (Boston, MA).