Efficacy
cardiac arrest
PCT, CARDIAC ARREST
Plasma levels of IL-1β and IFN-γ were below detection thresholds in more than 50% of the patients at randomization and at 48 h, and these cytokines were not considered for analyses. Trends and median values in cytokine plasma levels within 72 h of randomization are reported in Fig. Plasma cytokines levels within 72 h of randomization. Median and interquartile range for cytokine plasma levels in the control group and in the hemoadsorption group, within 72 h of randomization. HOverall, we observed a downward trend for plasma levels of all cytokines throughout the 72 h post-randomization. 48 h after randomization, the median decrease in IL-6 plasma levels, relative to baseline, was 75% (60, 94) in the HA group versus 5% (− 47, 70) in the control group (In cytokines with low median plasma levels at baseline (< 10 pg/mL) including TNF-α, GM-CSF, IL-5, IL-2, and IL-4, absolute decreases at 48 h were small, but accounting for baseline values, a nonsignificant higher relative reduction was observed in the HA group versus the control group (Table Efficacy outcome: reduction in cytokines plasma levels within 48 h post-randomizationData are presented as median (interquartile range—IQR), and compared between groups with Fisher exact testAbsolute reduction is calculated as: (value at randomization - value at 48 h)Relative reduction is calculated as the ratio of the absolute reduction over the value at randomization. This ratio could not be calculated when value at randomization was under detection threshold*One patient in each group died within 48 h, reduction at 48 h could be evaluated in 10 patients in the control group and 8 patients in the hemoadsorption groupAmong patients with very high IL-6 level at randomization (> 10,000 pg/mL, Individual trajectories of Interleukin-6 plasma levels within 72 h of randomization. Individual trajectories of Interleukin-6 plasma levels within 72 h of randomization (There was no correlation between IL-6 plasma levels at randomization and time-to-ROSC, location of cardiac arrest (in- or out-of-hospital), presenting rhythm, lactate at admission or randomization, PCT at admission and CRP at admission (Pearson’s correlation coefficient < 0.6 for each).