Interventions
headaches, headache
For the 24-week, placebo-controlled treatment period, patients were randomized to eptinezumab 100 mg, eptinezumab 300 mg, or placebo IV every 12 weeks in a 1:1:1 fashion, with randomization stratified by monthly headache days (MHDs) at baseline (≤ 14 MHDs or > 14 MHDs) and by country. For the 48-week dose-blinded extension, patients who had received eptinezumab in the double-blind phase continued at their randomized dose (100 mg or 300 mg); patients who had received placebo were randomized 1:1 to eptinezumab 100 mg or 300 mg. Codes for randomization in the extension period were assigned at the start of the study. Eptinezumab was administered intravenously once every 3 months for 4 additional doses.Throughout the study, patients kept a headache eDiary, which comprised evening reports (completed daily regardless of the presence or absence of headaches) and headache reports (completed for each headache that occurred). The latter were used to document headache start and stop times, characteristics, symptoms, severity (mild, moderate, or severe), and acute medication intake in connection with the headache.