Main
hyperglycemia, T2D, weight loss
HYPERGLYCEMIA, PATHOGENESIS
As the progressive deterioration of normal beta-cell function is regarded as a determining factor for the onset and subsequent progression of T2D, re-establishing beta-cell function is considered pivotal to improving the pathogenesis of T2DAlthough a substantial diet-induced weight loss is consistent with improved beta-cell functionIntensive structured weight management programs aiming for weight loss are recommended alongside pharmacological therapy to treat hyperglycemiaAccordingly, the primary objective of this study was to investigate the change in DI during the final 30 min of clamp-induced hyperglycemia (late-phase DI) after a 16-week intervention with different volumes of exercise in addition to diet-induced weight loss and algorithm-guided pharmacological management in people with newly diagnosed T2D. We hypothesized that late-phase DI would increase with increasing volumes of exercise in combination with diet-induced weight loss. Furthermore, we expected that both moderate and high volumes of exercise in combination with a diet-induced weight loss intervention would be superior to the control in improving late-phase DI