Ethics approval and consent to participate
The PLUSS trial has been approved by the following human research ethics committees:1. The Royal Children’s Hospital, Melbourne, Australia: Reference 36383.2. Mercy Health Human Research Ethics Committee, Melbourne, Australia: Reference 2019–017.3. Mater Misericordiae Ltd Human Research Ethics Committee, Brisbane, Australia: Reference 55212.4. Central Health and Disability Ethics Committee, New Zealand: Reference 17/CEN/203.5. SINGHEALTH Centralised Institutional Review Board (CIRB), Singapore: Reference 2019/2801.6. University of Alberta Research Ethics Office, Canada: Reference Pro00083572.