Conclusions
NSCLC, ALI, non-cancer, inflammation, cancer, psychiatric, depressed, MDD, depression
NON-SMALL CELL LUNG CANCER, INFLAMMATION, CANCER, PATHOPHYSIOLOGY, DISORDERS, NSCLC
Systemic inflammatory biomarkers—NLR, PLR, ALI—are known predictors of advanced NSCLC survival [Immune-based therapies are standard of care in patients with non-small cell lung cancer [Close inspection of the data highlighted individual differences in the association between depression and inflammation elevations. That is, data show the majority of depressed patients had prognostically poor PLR (It is unknown if the depression/inflammation association would remain once cancer treatment begins. However, we have shown the The validity of the depression and SIR associations found here is supported by pathophysiology studies of psychiatric disorders [The non-cancer studies are important for interpreting the present findings, as in combination, they show a dose response relationship between depression severity ad elevated NLR. This data provides a conceptual replication, i.e. the elevated depression/elevated inflammation effect is the same, but now observed in a cancer sample. PLR and ALI have not been studied in MDD patients, but here the depression/NLR effect was replicated in PLR and ALI analyses, adding reliability and validity the findings. And, it is likely that similar effects would be found with MDD patients. A plausible interpretation of this data is a differential effect of depression severity which “adds” to patients’ basal level of inflammation arising from other sources. This may be a contributing mechanism to the uniquely high rates of depression in found LC patients at diagnosis [Strengths and weaknesses are considered. Uniform timing of data collection during the difficult diagnostic period was clinically and methodologically important. The sample was at least equal to if not larger than those found in multiple SIR/OS meta analyses [In conclusion, new therapies for NSCLC are changing previously bleak, 5-month survival prognosis [