Discussion
gout
GOUT
The aim of this study was to investigate the efficacy and safety of a tart cherry supplementary citrate (TaCCi) mixture on urine pH, sUA, and gout flares in gout patients initiating ULT with XOI febuxostat. The hypothesis was that tart cherry supplement could ameliorate acidic urine by improving MetS components. Our findings indicate that the TaCCi mixture had similar efficacy and safety to sodium bicarbonate or citrate mixture for urine alkalization. However, the TaCCi mixture group demonstrated greater improvement in UACR and CRP compared to the other two groups, and fewer gout flares than the sodium bicarbonate group. No between-group differences were observed for MetS components over the 12-week study period.Low urine pH is a major risk factor for renal system uric acid crystallization formation and stone development [Observational studies have suggested that tart cherry intake may reduce gout flare frequency [The study had several limitations. Firstly, it was conducted at a single clinical center and was open label. Secondly, only male patients with eGFR > 60 ml/min/1.73m