INTRODUCTION
toxicity, Gastric cancer, deaths, cancer
GASTRIC CANCER, CANCER, WEST, METASTASIS
Gastric cancer (GC) is the fifth most frequently diagnosed cancer and the third leading cause of cancer‐related deaths worldwide with an extremely high incidence in East Asian countries, especially in China and Japan.Fluorouracil/platinum‐based doublets or triplets systemic chemotherapy is the standard first‐line treatment for advanced GC, as recommended by the West and East clinical guidelines.At present, anticancer drugs are mainly administered intravenously; most of them cannot cross the peritoneum‐serum barrier and reach the disseminated nodule efficiently. Over the past few decades, intraperitoneal administration of anticancer drugs, such as cisplatin, paclitaxel, mitomycin, and docetaxel, has been proven to be effective for peritoneal metastasis.Hence, we developed a new intensive regimen that added intraperitoneal high‐dose paclitaxel to systemic chemotherapy SOX with a modified dosage to decrease the potential risk of severe toxicity and conducted a phase II study to evaluate the efficacy and safety of the triplets combination in GC patients with synchronous peritoneal metastasis.