Author contributions
AJ, DT, MB and LS contributed to the conceptualisation and development of the trial. MK, TC, CB, US, ST, FL and DT contributed to the correlative science within this manuscript. ST, MK, FL, DE, CL, JS, AJ and DT contributed to the implementation, investigation and clinical trial analysis. JG, FL, ST, MK, MB, PM, AJ and DT played a key role in the bioinformatics and genomics analysis of patients screened and enrolled on the trial. All authors were involved in writing, reviewing and editing the manuscript.