Evaluating SARS-CoV-2 cases within the epidemiological context of regional and temporal Omicron surges
AIDS
AIDS, CNS INFECTIONS, HEMATOLOGIC MALIGNANCY
We plotted cases and hospitalizations by week of diagnosis and T/C status to evaluate the temporal distribution of COVID-19 Omicron infections in relationship to time of T/C administration. To place the cases in the context of the COVID-19 patterns in the community and which variants were circulating in the San Diego area during the same time interval, we used data from the SEARCH GitHub repository to develop a graph of mean weekly wastewater concentrations of SARS-CoV-2 by variant type.We examined the impact of T/C on rates of COVID-19 hospitalization and ICU admission by comparing the rates of each outcome among patients who received T/C before developing COVID-19 and those who developed it after receiving T/C. We calculated rate ratios, 95% confidence intervals, and two-tail p-values. For this analysis, we also examined the rates by underlying condition (hematologic malignancy, bone marrow transplantation, solid organ transplantation, and other, which included patients with underlying immunosuppression such as rheumatologic conditions or AIDS). We also calculated the E-values for all associations of interest in order to quantify the strength of an unmeasured confounder to explain away the observed association. The e-value quantifies the strength of an unmeasured confounder to explain away the observed association [This study was determined by the UC San Diego Institutional Review Board to be exempt from Institutional Review Board requirements under categories 45 CFR 46.104(d), category 4.