Statistical Analysis
REGRESSION
Univariate and multivariable logistic regression analyses were performed to assess whether PEP changes, protocol availability, funding source, treatment location, treatment modality, or accrual goals were associated with US Food and Drug Administration approval or trial positivity, determined by whether the trial met the prespecified statistical threshold for PEP positivity. Statistical analyses were performed in Prism, version 9.1.2 (GraphPad) and RStudio, version 2021.09.0 (R Project for Statistical Computing). Two-sided 