Discussion
MR, hypertension, OA, pain
REGRESSION, HYPERTENSION, OSTEOARTHRITIS
Our MR study did not yield any evidence to suggest a significant association between blood pressure and OA. However, we identified a causal relationship between PSDs and aldosterone antagonists in relation to all OA, indicating a protective effect against OA. This result was nominally replicated with statistical significance in the validation data set and exhibited significant correlation in the linear regression analysis. Furthermore, our sensitivity analysis provides additional support for the reliability of these findings.The relationship between blood pressure and OA has been extensively studied. A previous study found a gender difference in the association between hypertension and the imaging of OA [In our study, PSDs and aldosterone antagonists were thoroughly validated and found to have a causal relationship with OA. However, previous studies have also indicated a potential association between other antihypertensive drugs and OA. A study using data from the Osteoarthritis initiative demonstrated that CCB may exacerbate pain in patients with OA. The findings indicate that, during the 4-year follow-up period, the pain score of the CCB group was higher compared to other antihypertensive drugs. Although no statistical difference was observed, the CCB group exhibited the narrowest joint gap across multiple test groups [OA is considered to be closely associated with a series of inflammatory reactions. Prior research has demonstrated that Aldosterone plays a role in promoting inflammatory effects [Our study's advantage is utilizing MR to investigate the effects of blood pressure and antihypertensive drugs on OA. By upholding MR's basic hypotheses, we minimized bias and confounding factors to a great extent. In addition, we employed publicly available data in conjunction with our research design to screen out instrumental variables, ensuring Instrumental Variables Estimation's maximum reliability. We further validated the results’ dependability via sensitivity analysis.However, this research also has its limitations: first, the GWAS data we used was limited to individuals of European ancestry. Unfortunately, we could not explore the effects of blood pressure and antihypertensive drugs on other races, since sufficient data were not available. Second, the ability of Instrumental Variables Estimation to explain related genetic traits is limited. Finally, as MR studies primarily deal with assessing associated effects, additional high-quality research is needed to verify the improvement of antihypertensive drugs on OA.