Conclusion
LUNG DISEASE
Collectively, our data implies that BA either contribute to or predict early pathomechanisms involved in establishing both the microbial and inflammatory landscapes in CF lungs early in life. Although the use of a potent prokinetic does not reduce BA levels in the lower airways, other strategies to modulate the lung exposure to BA should be explored. Furthermore, the identification of non-invasive biomarkers of BA exposure could provide useful tools to predict infants at greatest risk of progressive lung disease.