Acknowledgements
We thank all the generous volunteer subjects who enrolled in the study. This work was supported by the Key Research and Development Program of Zhejiang Province (2021C03200, J.J., H.L., H.Z.); the Key Program of Health Commission of Zhejiang Province/Science Foundation of National Health Commission (WKJ-ZJ-2221, H.L., H.Z.); the Major Program of Zhejiang Municipal Natural Science Foundation (LD22H190001, J.J., H.Z.); the Explorer Program of Zhejiang Municipal Natural Science Foundation (LQ23H100001, H.Z.). CanSino Biologics contributed to the study design and clinical data collection; CanSino Biologics coauthors revised and approved the final version of the manuscript.