Metabolomic and lipidomic changes associated with neonatal hypoglycaemia
POSITIVE, NEONATAL HYPOGLYCAEMIA, NEONATAL HYPOGLYCAEMIA
Neonatal hypoglycaemia was associated with five variables in cord blood and 72 variables in maternal blood (Fig. Associations between individual metabolites in maternal blood in trimesters 1, 2 and 3 (At 24 weeks, no species were associated with subsequent neonatal hypoglycaemia in offspring. At 34 weeks, derivatives of a fatty acid, amino acids and a polyamine (2,3-dihydroxy-5-methylthio-4-pentenoate [DMTPA] [OR 2.27 (1.44, 3.56)], In cord blood, uridine monophosphate (OR 0.10 [0.09, 0.53]) was negatively associated with neonatal hypoglycaemia. Positive associations were seen with maltose, (S)-3-hydroxybutyrylcarnitine (OR 4.09 [1.81, 9.23], a polyamine ((N(1) + N(8))-acetylspermidine, OR 9.59 [2.66, 34.60]) and methylguanidine (OR 9.59 [2.66, 34.60]).