Study endpoints
malaria
ADVERSE EVENTS, SECONDARY, MALARIA
The primary trial endpoint was safety, measured as the incidence of adverse events related to study medications during a 6-day follow-up period after randomization to each treatment arm (starting from day 0 of administration of anthelminthic drugs to 3 days after completion of the first cycle of SMC drugs. Unsolicited adverse events were recorded during a 30-day passive surveillance period after each SMC cycle, and SAEs throughout the study period. The following secondary endpoints were assessed before and after co-administration of SMC with anthelminthic drugs (i.e. 1 month after completion of the last SMC cycle which corresponded to the end of malaria transmission season: (i) the prevalence and intensity of 