Outcomes.
diarrheal, diarrhea, acute kidney injury
REGRESSION, EVENTS, BLOODY DIARRHEA, HEMOLYTIC UREMIC SYNDROME
Study groups did not differ in the primary outcome, with 52% (16/31) of children in the FilmArray BioFire group and 62% (18/29) of those in the standard-of-care group having a blood test performed within 72 h of randomization (difference of −10.5%, 95% CI of −35.4 to 14.5%) (Study outcomesData include all events from the index ED visit until day 14 of follow-up, unless otherwise specified. No children experienced the outcomes of intensive care unit admission, hemolytic uremic syndrome, acute kidney injury, or renal replacement therapy.Between-group comparisons used the Mann-Whitney U test for continuous variables and chi-square tests and Fisher's exact tests for categorical variables, as appropriate. The Holm method was used to adjust Included only those who were discharged from the emergency department (N = 27 in each study arm).Reported on a scale of 0 to 10. Data were missing for 3 children in the BioFire FilmArray arm.The classification and regression tree (CART) model identified duration of bloody diarrhea (≤38 h) and the number of diarrheal episodes in any given 24-h period (≤5 or >9) as being predictive of bacteria identification (Classification and regression tree analysis for predicting bacteria identification with the BioFire FilmArray gastrointestinal panel. The analysis identified baseline duration of bloody diarrhea (≤38 h) and the number of diarrhea episodes in any given 24-h period (≤5 or >9 episodes) as prediction of testing positive for bacteria target. Testing positive for bacteria was not observed in study participants without these clinical findings.