MAD
This study arm was a multiple-dose escalation trial of AD16 in the 30 mg (bid) and 40 mg (bid) groups, each consisting of 10 subjects. The trial drug and placebo were administered to eight and two subjects twice a day, respectively, in each group from day 3 to day 8. This study aimed to assess the safety, tolerability, and PK features of AD16 in healthy adults following its repeated administrations.