Reduction in cigarettes smoked per day
There was a relative increase in participants reporting reduction in the number of cigarettes smoked per day in VBA + LA and VBA + CO arms compared to VBA at all follow up points. At 4wks this was statistically significant in both the VBA + LA arm (RR 1.30 (95% CI: 1.10, 1.54)) and the VBA + CO arm (RR 1.23 (95% CI: 1.03, 1.49)). At 12wks (RR 1.15 (95% CI: 1.00, 1.32), (RR 1.11 (95% CI: 0.93, 1.32)) and 26wks (RR 1.03 (95%CI: 0.94, 1.14)), (RR 1.09 (95%CI: 0.95, 1.26)) CIs included no effect (Table 