2.3. Intervention
This study was designed as a clinical controlled trial in which intervention group and control group were matched for age, age at menarche, menopausal symptoms and drug use status at enrollment. The criterion of matching referred that no statistical significance was detected in the difference analyses of baseline indicators according to clinical consideration (Comparison of the baseline characteristics between groups.Two group were matched for age, age at menarche, menopausal symptoms and drug use status.CONSORT flow chart.