Author contributions
PD
VCMN conceptualised, designed, and performed experiments; curated and analysed the data; and wrote, edited, and reviewed the original manuscript. LO and AP contributed to performing and analysing the randomized controlled trial. EE, JD, and AV performed experiment and analysed data. SJ performed microbiome experiments and bioinformatic analysis. AM, KF, and PD performed and analysed the single cell RNAseq. GM and LN contributed analysing the gingival crevicular fluid experiments and analysis. DF and PS contributed with RNAseq analysis. PS, LN, and MI provided resources and critically reviewed the manuscript. All co-authors reviewed the manuscript.