Conclusion
Psychotic Disorders, OCD
Therapist-guided ICBT combined with medication is as effective as face-to-face CBGT combined with medication for OCD. ICBT combined with medication is more cost-effective than CBGT combined with medication and conventional medical treatment. It is expected to become an efficacious and economic alternative for adults with OCD when face-to-face CBGT is not available.This work was supported by the National Natural Science Foundation of China (82230045, 81771460), the General project of Shanghai Municipal Health Commission (202140054), the Academic Leader of Health Discipline of Shanghai Municipal Health Commission (2022XD025), the Shanghai Jiaotong University "star of Jiaotong University" medical engineering cross research fund key project (YG2021ZD28), the Shanghai Science and Technology Committee Project (20DZ2253800), and the Key Laboratory of Psychotic Disorders (13dz2260500).Conflicts of Interest: None declared.CONSORT-eHEALTH checklist (V 1.6.1).