Effect of both interventions on ReHo
aMCI
CORTEX, BRAIN, INTERACTION
There was no significant between-group difference in the baseline ReHo values. Interaction analysis (Brain regions with significant interaction and results of the Scatter plot of correlations between altered neuroimaging indexes and neuropsychological performance. The changes in ReHo values in the right anterior cingulate/paracingulate gyrus and the left dorsolateral superior frontal gyrus were positively correlated with changes (post-pre) in MoCA, MMSE, and VFT scores in the rEAP group. The FC alterations between the vmPFC and left angular gyrus were positively correlated with changes in MMSE scores in the HE group. Colored areas represent the 95% confidence interval.Brain regions with significant interactionCingulum_Ant_R, right anterior cingulate/paracingulate cortex; Frontal_Sup_L, left dorsolateral superior frontal gyrus; Temporal_Mid_R, right middle temporal gyrus; Angular_L, left angular gyrus.Correlations between altered neuroimaging indexes and changes in neuropsychological test scoresMoCA, Montreal Cognitive Assessment; MMSE, Mini-Mental State Examination; AVLT, Auditory Verbal Learning Test; VFT, Verbal Fluency Test; BNT, Boston Naming Test; STT, Shape Trail Test; SDMT, Symbol Digit Modalities Test; ADL, Activities of Daily Living Scale; Cingulum_Ant_R, right anterior cingulate/paracingulate cortex; Frontal_Sup_L, left dorsolateral superior frontal gyrus; RMTG, right middle temporal gyrus; LAG, left angular gyrus.Furthermore, in the naMCI subgroup, changes in the ReHo value in the left dl-SFG were positively and negatively correlated with changes in VFT and STT-A scores in the rEAP group, respectively. However, the changes in the ReHo value of the left dl-SFG and the STT-A score in the HE group were negatively correlated. In the aMCI subgroup, there was a positive correlation between the changes in the ReHo value and MMSE score in the rEAP group. However, the changes of the ReHo value in the left dl-SFG were positively and negatively correlated with the changes of MMSE and SDMT scores in the HE group (