Conclusions
reduced pain
In conclusion, FCH significantly improved mobility and joint comfort, and reduced pain. It also had a significant impact on the quality of life, highlighted by an improvement of physical health and function. Biological activity of human FCH metabolites give us clues on the mechanisms potentially contributing to the observed articular improvement following FCH supplementation. The observed effects of FCH on mobility and joint comfort will need to be confirmed in a larger randomized placebo-controlled clinical trial, ideally including radiographic or structural changes as well as biochemical markers of joint deterioration. This study will be especially useful for the design of such a randomized placebo-controlled clinical trial, particularly regarding the choice of the primary outcome.