Pharmacokinetics
PK parameters were calculated from the individual plasma concentrations, and urine concentrations and volumes, by non-compartmental analysis using Phoenix WinNonlin version 8.2.0.4383 (Certara, Princeton, NJ, USA). Summary statistics (All concentration values below the quantification limit were treated as missing. A terminal phase could not be defined for some concentration-time curves, and consequently no value for AUC