1. Introduction
High-density lipoproteins, hypertension, High-density lipoprotein, Overweight
ATHEROSCLEROSIS, HYPERTENSION, CORONARY ARTERY DISEASE, DYSLIPIDEMIA
These authors contributed equally to this work.High-density lipoproteins (HDLs) are complex particles composed of a wide range of lipids, proteins, hormones and vitamins that confer to the HDL particles multiple cardiovascular protective properties, mainly against the development of atherosclerosis. Among other factors, the HDL lipidome is affected by diet. We hypothesized that diet supplementation with ω3 (docosahexaenoic acid: DHA and eicosapentaenoic acid: EPA) and phytosterols (PhyS) would improve the HDL lipid profile. Overweight subjects (High-density lipoprotein (HDL) particles have been demonstrated to possess various antiatherogenic characteristics, encompassing anti-inflammatory, antioxidant, antiapoptotic, antithrombotic and vasodilatory effects [It is now well evidenced that the HDL lipidome is significantly altered in pathological conditions like dyslipidemia, hypertension, coronary artery disease [We previously reported that daily intake of milk products containing ω3 (docosahexanoic acid: DHA and eicosapentaenoic acid: EPA) affects the composition of the HDL proteome, with a significant increase in key proteins involved in HDL metabolism [