Immunosuppressive Regimen
All included SOTR attended the outpatient clinic of the UMCG and were treated according to standard immunosuppressive therapies, with revision of therapy effectiveness at least once per year. Immunosuppressive maintenance therapies were generally tacrolimus-based, with addition of mycophenolate mofetil (MMF), and prednisolone. Other immunosuppressive drugs used less frequently were cyclosporine, everolimus, sirolimus, and azathioprine. Although immunosuppressive regimens may be adapted on an individual basis, standard protocol target trough concentrations of tacrolimus and cyclosporine in the UMCG are shown in Immunosuppressive target trough concentration per transplant type in the UMCG.
∼ target trough concentrations are not listed in UMCG protocols. *Cyclosporine is not used for this type of transplantation.