Characteristics of bone marrow regulatory B cells and PET‐CT scan in the elderly NDMM patients
MM
MULTIPLE MYELOMA
Flow cytometry analysis was applied to characterize the BM‐derived CD19Analysis of bone marrow‐derived regulatory B cells and PET/CT scan in the elderly with multiple myeloma. (A). Bone marrow from MM patients was stained with CD19, CD24, and CD38 by flow cytometry. Bregs are phenotypically identified as a distinct subset of CD19Fifty‐seven patients received PET/CT scans at diagnosis and 80.7% presented positive lesions. The median SUVmax was 3.68 (interquartile range 2.85–5.76). The difference in induction efficacy between patients with SUVmax >4.2 or SUVmax ≤4.2 was insignificant. However, the median PFS was shorter in patients with SUVmax >4.2 than in patients with SUVmax ≤4.2 (16.0 m vs. not reached, Since Bregs' ratio <10% and SUVmax >4.2 were significantly correlated with more inferior OS, we stratified the elderly MM patients into different groups according to the number of adverse risk factors. Among patients with available Breg and PET/CT scan data, 23.8% had two adverse factors, 33.3% had only one adverse factor, and 42.9% had neither of the two adverse factors. As a result, patients with both Bregs' ratio < 10% and SUVmax >4.2 experienced inferior PFS and OS than the other two groups (