Changes in laboratory parameters before and after vaccination
CHRONIC DISEASES
Ten parameters were detected at seven time points to assess the safety profile of CoronaVac in coagulation activity and blood glucose levels. The nine parameters related to coagulation function were platelet count, PT, APTT, TT, fibrinogen, INR, D-dimer, ESR and anti-heparin/platelet factor 4 antibody.At each time point, the means of each laboratory parameter fell within the laboratory normal ranges (Dynamic changes in the means of laboratory parameters at each time point. To simulate the post-marketing vaccination condition, the oral consultation method was used, rather than laboratory tests, to screen participants. Therefore, subjects unaware of their chronic diseases, which were not contraindicated by vaccination, were recruited. After detecting laboratory parameters of blood samples, physicians evaluated whether laboratory results were laboratory abnormalities and clinically significant.According to the relevant guidelines (Grades Changes in the laboratory parameters between prevaccination and 28 days after the second dose in comparison with prevaccination. 