Outcomes
volume reduction
All outcomes reported in this manuscript were prespecified in the REST trial protocol.The REST trial evaluated a complex intervention that was intended to facilitate lower tidal volume mechanical ventilation. To evaluate whether there was a treatment effect based on tidal volume reduction, an exploratory analysis of patients who had a reduction in tidal volume (defined as a change from baseline to day 3 of at least 2 mL/kg PBW), compared with patients in standard care who had no reduction (defined as a change in tidal volume from baseline to day 3 no greater than 2 mL/kg PBW) was performed.