1. Introduction
Obesity, obesity, MH, cancer, diabetes mellitus, CVD
OBESITY, OBESITY, INSULIN SENSITIVITY, CARDIOVASCULAR DISEASES, CVD, CANCER, DIABETES MELLITUS, INSULIN RESISTANCE, INSULIN RESISTANCE
Background: Unripe avocados (Obesity is a global concern associated with adverse health consequences, which include increased risk of cardiovascular diseases (CVD), diabetes mellitus and cancer [Mannoheptulose (MH) is a seven-carbon monosaccharide that naturally occurs in unripe avocados (Human studies describing consumption of MH are extremely limited. To our knowledge, only one previous study in humans administered MH contained in avocados (at a dose of 2–13 g), to eight men [The present study evaluated the effects of supplementing the diet for 12 weeks with 10 g of extract made from dried, unripe avocados that are naturally high in MH, versus a placebo made from cornmeal, on glycaemia and cardiometabolic risk factors in nondiabetic humans with obesity. The primary outcome was glucose area under the curve (AUC) in response to an oral glucose tolerance test (OGTT). Secondary outcomes were changes in insulin AUC, insulin resistance assessed using the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), β-cell function (HOMA-β), Matsuda Insulin Sensitivity Index, cardiometabolic risk markers and autophagy gene expression.