Biomarker analysis
tumor
CPS, TUMOR, INFILTRATING
Baseline tumor biopsies were available in 94.1% (32/34) of patients. Patients with positive PD-L1 expression showed a numerically higher pCR rate (combined proportional score (CPS) ≥ 5 vs. CPS < 5, 63.6% vs. 28.6%, To further assess whether different immune cell subtypes within the TiME could predict treatment response, both baseline tumor biopsies and post-treatment surgical tissues were analyzed by the mIF assay. A total of 47 samples passed quality control and were tested in the final data analysis (23 who underwent gastroscopy and 24 who underwent surgery, including 17 samples that were paired).Patients achieving pCR had higher levels of infiltrating CD3