Study Limitations
Despite the prospective randomized setting chosen for our feasibility trial, potential limitations need to be pointed out. Since the trial was primarily designed to assess feasibility, the limited cohort size posed challenges for conducting subgroup analyses and evaluating potential variables that could influence feasibility. As patients were aware of their participation in the experimental and control arms of this trial, it is possible that compliance rates were higher than what might be expected in routine clinical care. To account for this potential limitation, we set a very high feasibility threshold that strongly exceeded that of previous trials [