2.4. Statistical Analysis
pain
The sample size was calculated according to the intensity of joint pain (VAS) as the primary efficacy endpoint. On the basis of a standard deviation of VAS score of 1.48 reported in a similar population [Data of all participants who fulfilled the inclusion criteria and completed the 8-week period of the trial were analyzed. Frequencies and percentages are used for the expression of categorical variables, and mean ± standard deviation (SD) is used for the expression of continuous variables. The chi-square test or Fisher’s exact test was used for the comparison of categorical variables between the study groups, and Student’s 