Ethics approval and consent to participate
iDiapason trial has been conducted in accordance with the Declaration of Helsinki and French laws and regulations. The study has received its approval from the French ethics committee (Comité de Protection des Personnes Ile de France VI) as well from the French Drug Safety Agency (Agence Nationale de Sécurité du Médicament et des Produits de Santé) (EudraCT 2015-003102-17). The iDIAPASON study has received its approval from the French ethical committee (Comité de Protection des Personnes Ile de France VI) as well from the French Drug Safety Agency (Agence Nationale de Sécurité du Médicament et des Produits de Santé). Written informed consent was sought before inclusion or from a patient’s relative or an emergency inclusion if their absence according to French law.