Patients
glioblastoma, tumor, gliosarcoma
TUMOR, RECURRENCE, DISEASE, GLIOSARCOMA, GLIOBLASTOMA
Adult patients with histologically confirmed glioblastoma or gliosarcoma, presenting with documented failure of previous surgical resection, chemotherapy and/or radiation at first or second recurrence, with a Karnofsky performance score of at least 70, were eligible. All patients were required to have a single contrast-enhancing tumor of at least 1 cm in two planes but no more than 4 cm in any single plane, as assessed by magnetic resonance imaging (MRI). Surgical resection must not have been possible or planned as part of the treatment for their presentation, and the tumor must have been accessible for stereotactic delivery of DNX-2401. Patients with multifocal or bilateral disease were excluded. The full inclusion and exclusion criteria are detailed in 