Patient disposition
TNBC, tumor, advanced/metastatic solid tumors, breast cancer
TUMOR, BREAST CANCER
In Module 1A, 33 patients with advanced/metastatic solid tumors were enrolled. Patients initially received samuraciclib at a starting dose of 120 mg, with 4 additional dose levels of 240 mg OD, 360 mg OD, 480 mg OD and 180 mg twice daily (BID) explored. Eleven patients were recruited to a breast cancer expansion cohort to evaluate the pharmacodynamic effects of samuraciclib in tumor tissue.In Module 1B-1, 23 patients with locally advanced and/or metastatic TNBC received samuraciclib 360 mg OD.In Module 2A, 31 patients with post-CDK4/6 inhibitor HR+/HER2− advanced breast cancer received samuraciclib in combination with fulvestrant: 6 at 240 mg OD and 25 at 360 mg OD of samuraciclib (Supplementary Fig. 