Differences between PISEI subjects and healthy subjects in resting‐state and Stroop task state respectively
aphasia
In this study, the fNIRS‐based analysis disclosed that the oxyhemoglobin content in the left DLPFC, the right PMC and the right SM1 was markedly heightened in PISEI patients during the Stroop task compared with the resting state. Nevertheless, the oxyhemoglobin concentrations in these brain regions were considerably lower than those in healthy subjects, implying that the occurrence of PISEI may be related to the suppression of blood oxygen metabolism and functional activity in the DLPFC, PMC and SM1 brain regions. These results may be because DLPFC is a susceptible area for memory, attention, and control, which are closely related to cognitive functions,It is still difficult to screen and diagnose PISEI in clinical practice, and its diagnosis primarily relies on patients' clinical symptoms and neuropsychological scales, which lack precise and quantitative evaluation indexes. Additionally, the scales used to assess PISEI patients are readily affected by factors such as aphasia, patients' literacy and collaboration in the assessment process, making it extremely difficult to complete prompt screening and accurate diagnosis of PISEI.Compared with traditional clinical scales, fNIRS has the following advantages as a screening and diagnostic tool for PISEI: (1) swift and handy: fNIRS can construct a predictive model for PISEI by obtaining cerebral hemodynamic data from PISEI patients and healthy adults, and incorporating intelligent algorithms such as big data and machine learning to recognize PISEI swiftly and conveniently at an early stage.