Implications of all the available evidence
HIV-1 INFECTION
Our study identifies for the first time CD33/Siglec-3 as a biological marker of HIV-1 control in the absence of antiretroviral treatment and points towards its critical involvement HIV-1 infection. Other Siglec family members have been reported to be responsible for the capture and storage of pathogens by mature dendritic cells and for trans-infection between infected dendritic cells and target cells (e.g., Siglec-1 and Siglec-7). Here we identify plasma CD33/Siglec-3 levels as a biomarker associated with HIV-1 control during the clinical BCN02 trial but also in a large cohort of individuals with chronic, untreated HIV-1 infection. Moreover, addition of anti-CD33 monoclonal antibodies to 