Background
ST-segment elevation myocardial infarction, hyperaemia, coronary artery disease
CARDIOGENIC SHOCK, HYPERAEMIA, CORONARY ARTERY DISEASE
When treating patients who have suffered an ST-segment elevation myocardial infarction (STEMI), the initial percutaneous coronary intervention (PCI) should be performed as quickly as possible, and it is recommended that only infarct-related artery (IRA) PCI be performed [Despite all improvements, fractional flow reserve (FFR), an invasive hyperemic hemodynamic physiology evaluation method, remains the gold standard for physiological evaluation [Furthermore, compared to angiography-guided PCI, FFR-guided PCI significantly reduces reinfarction and mortality rates [The instantaneous wave-free ratio (iFR) is an additional adenosine-free physiology evaluation method that has been introduced in clinical practice because adenosine-caused hyperaemia is very uncomfortable and creates an additional risk for patients. When compared to FFR, iFR is responsible for 27.7% fewer adverse procedural reactions [Two extensive clinical studies compared iFR- and FFR-based PCI in patients with stable coronary artery disease or non-STEMI with a 1-year follow-up [Since physiology evaluation is underused worldwide, it was believed that the wireless physiology evaluation method may become a game changer. Even though it can be used offline, it is suitable for physiological evaluation in hemodynamically unstable patients with cardiogenic shock, in contrast to wire-based methods, which significantly extend the procedure time [Despite all novelties, physiology-guided PCIs, especially in ACS patients, remain underused worldwide. Therefore, this study was designed to compare the cardiovascular outcomes of visually estimated only-guided PCI versus noninvasive physiology assessment-guided PCI. As a result, the purpose of the study was to investigate the differences between the non-culprit lesion significance evaluation methods in terms of the quality of life (QOL), the rate of rehospitalization, and the rate of revascularization within the first 12 months following the initial treatment.