Author contributions
ALV
ALV designed and conceptualized the study. CMFD, ZR, FD, MW, and ALV designed the clinical trial. ALV and CMFD were responsible for supervision and coordination. CMFD, EMB, FD, FL, DN, and RKB provided patients and surgery. EB, PZ, NT, ISCV, PvdS, and RvW were responsible for bioinformatics and statistical analysis. EMB, EB, PZ, CMFD, ALV, ISCV, EW, PvdS, RvW, AC, ALK, DH, EAHW, AV, LC, SL, and MLML performed data collection, analysis, and interpretation. EB, ALV, NT, AV, PZ, LC, and ISCV performed pre-clinical and post-surgery in vitro and in vivo analysis. EMB, EB, ISCV, EW, DH, RKB, ALK, AC, EAHW, NT, AV, PZ, LC, RvW, PvdS, DH, SL, MLML, ZR, MW, DN, FL, FD, ALV, and CMFD were responsible for manuscript preparation, writing, and final approval. The corresponding author had full access to all of the data and the final responsibility to submit for publication. All authors had final responsibility for the decision to submit for publication.