Toxicities
nausea, diarrhea, fatigue, leukopenia, anemia, lymphopenia, chills
ADENOVIRUS, LEUKOPENIA, ADVERSE EVENTS, ANEMIA, LYMPHOPENIA
By the study endpoint (day 30), a total of 115 adverse events (AEs) were documented. Ninety-two percent of the AEs were grade 1 (mild) and grade 2 (moderate). Several of treatment-related AEs could be either attributed to Ad5-IL-12 adenovirus (flu-like symptoms, chills, fatigue, altered liver enzyme AST/ALT ratio) or the prodrugs such as diarrhea, anemia, nausea, lymphopenia, leukopenia; 