Outcomes
SECONDARY, HBP
The primary endpoint was the incidence of si-SSI, defined according to CDC criteria for SSI [A specific subgroup analysis was planned for the primary endpoint evaluating outcomes in the following subgroups: major hepatic resection, pancreatic resection, bilioenteric reconstruction and open or laparoscopic approach. The study secondary endpoints were overall major postoperative morbidity in both groups, defined as Clavien-Dindo classification class ≥ IIIa [All patients were followed-up for the first 30 postoperative days, for both primary and secondary outcomes. During immediate postoperative period daily physical examination of the patient was performed by attending surgeons of the study team. After hospital discharge, all patients were followed-up in outpatients’ clinic for the second and fourth postoperative weeks to ensure post-discharge si-SSI detection. Complementary tests included aseptically obtained wound exudate cultures. All diagnosed si-SSI were confirmed by the reference HBP staff surgeons of the study team. The study protocol was published and is available online at 