1. Introduction
ASD, Autism spectrum disorder
SECONDARY
Autism spectrum disorder (ASD) affects 1 in 54 children in US and has profound effects on self-reported quality of life (QOL) as well as QOL of family members [Recently, two trials of cord blood infusion in children with ASD have shown safety and feasibility of the intervention [Our objective was to develop a decision modeling framework to assess the cost-effectiveness of potentially efficacious therapies for ASD to inform future clinical trials and future drug development. While the cord blood intervention in a recent trial did not meet its primary or secondary endpoints, understanding combinations of ASD treatment efficacies and costs likely to be cost-effective for other interventions will prove critical. Findings from this analysis might inform future clinical trials and researchers on clinical endpoints, provide a framework for considering value-based payment for therapies proven efficacious, and identify remaining uncertainties requiring further data acquisition.