1. Introduction
SINUSOIDAL OBSTRUCTION SYNDROME, COMPLICATIONS, COMPLICATION
Sinusoidal obstruction syndrome (SOS) of the liver is a serious, sometimes life-threatening complication of chemotherapies and hematopoietic stem cell transplantation (HSCT) [Various studies have reported germline genetic variants in association with SOS. Most of these studies have used a candidate gene approach. They identified several genetic determinants of SOS in genes that encode for detoxification enzymes, particularly glutathione S transferases such as Since a majority of studies addressing complications of HSCT and similar other rare conditions lack the power to identify genetic predictors due to the small sample size, we used a strategy that is built on the strong link between the exposure to busulfan and the onset of SOS [