Introduction
colorectal cancer, cardiometabolic disease, CVD
COLORECTAL CANCER, CARDIOVASCULAR DISEASE, CVD, SECONDARY, GENOTOXICITY
Observational studies suggest that red and processed meat consumption is associated with an increased risk of cardiovascular disease (CVD) [Public health approaches have had limited success in inducing meaningful population level transitions to plant-based eating, due to culinary traditions, taste preferences, and social and cultural norms [Previous randomised controlled trials have found replacing total meat with mycoprotein based foods elicits reductions in total and LDL cholesterol. These trials report different responses in high density lipoprotein (HDL), and this may be due to differences in the study population demographics and baseline cardiometabolic disease risk status [Here, we present an analysis of secondary endpoints from the Mycomeat study. Mycomeat was a randomised crossover controlled dietary intervention trial comprising metabolically healthy males with faecal genotoxicity as the primary endpoint; a surrogate marker of colorectal cancer risk by evaluating the DNA damaging potential of foodstuff and dietary patterns within the colon [