Treatment outcomes
hypocortisolismus, tumor, endocrine complications, acute hemorrhagic disorder, acromegaly, sinusitis, headaches, Tumor, paresthesias, hypothyroidism, Acromegaly, intraoperative liquorrhea, Postoperative epistaxis, somatotropinomas, hemorrhagic complications, Endocrine Disorders, postoperative meningitis, headache, endocrine disorders, oedema
HYPOTHYROIDISM, TUMOR, SINUSITIS, TUMOR, ENDOCRINE DISORDERS, ACROMEGALY, DIABETES INSIPIDUS, PARESTHESIAS, OEDEMA, ACROMEGALY, POSTOPERATIVE MENINGITIS, ENDOCRINE DISORDERS, COMPLICATIONS

Anesthesia time, surgery time, and postoperative days of hospital stay.When analyzing the radicality degree of adenomectomies depending on the surgical technique, a complete tumor removal was possible 1.4 times (p<0.05) more frequent in adenomectomy with the endoscopic technique compared to the microscopic one (Volume comparison of surgical removal of somatotropinomas using a microscope and endoscope in patients with acromegaly.*the difference is statistically significant compared to the group operated with the microscope.After adenomectomy, patients in both groups showed a tendency to improve their somatic status (better general well-being, normalized arterial pressure, reduced oedema, and sweating): 19 (48.1%) patients in the microscopic adenomectomy group and 25 (57.1%) patients in the endoscopic adenomectomy group. The difference between groups was not statistically significant (OR=1.23, 95% CI [0.57–3.61], p>0.05). In addition, some patients noticed an improvement in neurological status (reduced severity of paresthesias and headaches and better emotional state): 17 (42.5%) patients in the microscopic group and 21 (42.5%) patients in the endoscopic group. The difference between groups was not statistically significant (OR=1.16, 95% CI [0.46–2.90], p>0.05). After the microscopic removal of the tumor, improvement in visual functions was observed in 10 (25.9%) patients, and after endoscopic removal, it was observed in 22 (51.8%) patients. The difference between groups was statistically significant (OR=3.07, 95% CI [1.12–8.41], p<0.05).As for the complications of surgical treatment, intraoperative liquorrhea was present in 21 (51.9%) patients operated on using a microscope and in 15 (35.7%) patients operated on using endoscopy. The intergroup difference was statistically significant (OR=3.02, 95% CI [1.21-7.50], p<0.05). One (3.7%) patient in group 1 and one (2.3%) patient in group 2 experienced a decrease in visual acuity (OR=2.12, 95% CI [0.13-35.17], p> 0.05). One microscopic patient (3.7%) demonstrated hemorrhagic complications (in the form of an acute hemorrhagic disorder of the brain circulation). One patient (3.7%) in group 1 and two (4.6%) patients in group 2 reported an increase in headache intensity postoperatively (OR=1.04, 95% CI [0.09–11.98], p>0.05). Postoperative epistaxis was observed in 2 patients in the endoscopic technique group and was absent in patients in the microscopic technique group. There were no cases of postoperative meningitis or development of sinusitis in the long term. Importantly, there was not a single case of lethal results in endoscopic and microscopic procedures for tumor removal. In some cases, the patients had endocrine complications following the tumor removal (The comparison of Postoperative Incidence of Endocrine Disorders in Patients with Acromegaly with Microscopic and Endoscopic Methods of Tumor Removal.The incidence of endocrine disorders varied depending on adenomectomy technique. Diabetes insipidus, hypocortisolismus, and hypothyroidism occurred more frequently after endoscopic rather than microscopic surgery. However, this difference is not statistically significant (p>0.05).In general, the complications following endoscopic intervention were mainly mild. Moderate and severe complications occurred less frequently compared to microscopic operations.