Statistical considerations
This was a single-arm study. According to the FOWARC study, nCT with mFOLFOX6 treatment alone led to a 6.6% pCR rate. We hypothesized that mFOLFOXIRI would further improve the rate of pCR to 16%. With a 1-sided type I error of 0.05 and a power of 80%, and with a 10% dropout rate considered, the intended number of patients was 46. All statistical analyses were conducted using SPSS ver. 22.0 software.