Study drug exposure
The median number of cycles was 4.0 in Cohorts 1–6 and 2.0 in Cohorts 7–12. The median treatment duration was 109 days (range 29–480) and 43 days (range 12–561), respectively. Notably, 1 patient in Cohort 8 received ≥24 cycles, 1 patient in Cohort 7 received ≥20 cycles, 1 patient in Cohort 6 received ≥17 cycles of treatment, 1 patient in Cohort 5 received ≥10 cycles, and 2 patients in Cohort 10 received ≥6 cycles of treatment.