DISCUSSION
SE, inflammation, epileptic
NONCONVULSIVE STATUS EPILEPTICUS, DISEASE COURSE, INFLAMMATION, RECRUITMENT, EPILEPTIC
On the basis of our previous study on the END‐IT score,In this prognostic study, the consecutive recruitment lasted for 12 years, which made it a larger database to explore the CSE predictors, compared with our previous study. The age distribution of patients in this prognostic study was closer to that in other study sample from different countries, like the USA and India.Etiology was also considered as a determinant factor in the functional outcome of SE.Nonconvulsive status epilepticus was distinguished from SE with prominent motor phenomena according to the latest definition and classification,The systemic inflammation commonly leads to lower level of serum albumin and may contribute to perpetuate epileptic activity.In our previous work, image was included as an independent predictor in END‐IT. But during clinical practice, we found that neuroimage was not available in each SE patient, which limited the widely use of END‐IT. What's more, the image item in END‐IT referred to the most serious findings during the disease course. A recent study showed that this might not be appropriate, since the remote lesions causing SE could lead to a higher score although they might not necessarily represent negative outcome predictor.Unlike the previous study which proposed END‐IT, based on the increased sample size, internal validation of this modified prediction model was performed this time, which made the modified prediction model more reliable. This is the first time to develop a nomogram and website calculator to present a prediction model for the outcome in CSE. For healthcare professionals, the nomogram can be used as a reference guide on wards and during consultations.