3. Discussion
chronic pain, psychiatric, pain
CHRONIC PAIN, DRUG SIDE EFFECTS, DRUG-DRUG INTERACTION
The clinical decision about whether to use opioids for CNCP should be guided by a risk-benefit consideration. This trial provides data on the clinical efficacy of the The advantages of using pharmacogenetics-based opioid therapy before analgesic prescription are well-documented. The present results showed that the group treated with genetic information indicated a significantly less pain intensity and improved physical function compared to the conventionally treated group. However, very few prospective studies have assessed clinical utility. A large retrospective economic analysis developed in 5288 patients genotyped adult patients in front of 22,357 controls has reported reduced direct medical charges per patient of around US$7000 [Moreover, the influence of pharmacogenetics on analgesic pharmacokinetics can be a determined factor in understanding interindividual analgesic response. In particular, 27% of the European population struggles with the proper metabolism of On the other hand, psychiatric needs in chronic pain patients remain challenging, even more in the south of Europe, where the number of public resources in mental health is lower [Despite the promising results, it is crucial to acknowledge that current research into using genetic information to guide pain treatment is still in its early stages. Baseline screening of any prescribed drug side effects is needed through validated scales before starting any new regimen for pain care. This includes routinely screening and monitoring patient perceptions and avoiding drug-drug interactions with PGx-guided decisions. Future algorithms to interpret the Therefore, additional studies are necessary to confirm and extend these findings by considering the cost of genetic testing, which may pose challenges when implemented into routine clinical practice. Nonetheless, the potential benefits of this novel approach have significant implications for improving pain management and enhancing patients’ overall well-being.