Introduction
metabolic syndrome, MetS
METABOLIC SYNDROME, INSULIN SENSITIVITY
In recent decades, metabolic syndrome (MetS) has become more prevalent, notably in less developed nations [The impact of exercise on boosting SIRT1 expression has been the main focus of numerous studies [Currently, various exercises are performed with different goals. Resistance training (RT) is a form of strength training exercise that focuses on gradually increasing the load on muscles to build strength. In this type of training, the muscles are required to exert force against an external load. It can be both safe and effective for older individuals [On the other hand, High-intensity interval training (HIIT) has been proven to enhance insulin sensitivity, reduce blood pressure, and improve body composition in adults ranging from 20 to 77 years old [In total, despite the importance of the physiological role of SIRT1 in people with MetS, the response of this protein to RT and HIIT in patients with MetS is not yet well known. Also, it is not clear which of these exercises is more useful in postmenopausal women with MetS. Moreover, most of the studies on MetS have focused on diet and aerobic training, followed by pharmacological treatments. There is a lack of information about the impact of HIIT and RT training. In an effort to bridge this knowledge gap, this study will analyze the influence of HIIT and RT training on SIRT1 levels among postmenopausal women diagnosed with metabolic syndrome. In this specific group of women, this research will enhance the comprehension of the correlation between exercise and SIRT1 levels. Accordingly, the present clinical trial study seeks to answer the following questions: Do 8 weeks of HIIT and RT training affect circulating levels of SIRT1? Is HIIT exercise a more effective strategy in increasing SIRT1 and improving metabolic indices compared to RT?