Safety Assessments
manic, dissociative symptoms, hallucinations, suspiciousness, psychotic symptoms
SIDE EFFECT
General side effects were measured by the Udvalg for Kliniske Undersogelser side effect rating scale (range, 0-144; higher score indicates more severe side effects) and the Frequency, Intensity, and Burden of Side Effects Rating Scale (range, 0-18; higher score indicates more severe side effects). Psychotogenic effects were measured with the 4-item positive symptom subscale of Brief Psychiatric Rating Scale consisting of suspiciousness, hallucinations, unusual thought content, and conceptual disorganization (range, 4-28; higher score indicates more severe psychotic symptoms). Dissociative effects were measured with the Clinician-Administered Dissociative States Scale (range, 0-92; higher score indicates more severe dissociative symptoms), and manic symptoms were assessed using the Young Mania Rating Scale (range, 0-60; higher score indicates more severe manic symptoms). The Columbia-Suicide Severity Rating Scale (range, 0-42; higher score indicating greater suicidal risk) was also rated throughout the trial for safety purposes.