3.3. Change in Mammographic Density over the Study Period
Women in the ISF Supplement arm appeared to have a larger absolute decline in dense area over time, by 1.3 cmWe conducted several sensitivity analyses to test the robustness of our observations. First, limiting the analysis to those who were compliant to the intervention (per-protocol analysis) did not improve the associations for both absolute change (We further stratified the analysis by time since menopause at enrolment. For women with a shorter duration since menopause (<5 years), there was a large absolute decline in mammographic density among women in the ISF supplement arm (−5.9 cm