Donepezil efficacy measures
’s verbal fluency and lexical fluency tests
ISAACS, SECONDARY, DEGENERATION, APC
Based on the study protocol of the Hippocampus Study [APCs of the MRI efficacy measures were computed as follows:APC represents the rate of change in the MRI measures in 1 year, counting from baseline (visit 1) to 12-month follow-up (visit 4). APC ranges from − 100 to 100%. Negative APC values indicate greater loss of volume or cortical thickness (i.e. greater degeneration) over 1 year. Almost all the individuals underwent baseline and follow-up MRI assessments within 1 year (mean = 11.6 months). However, a small number (10%) underwent the MRI scan earlier, between 6 and 11 months after baseline. To minimize this variability in follow-up time, we calculated the APCs accounting for the number of days passed between the first MRI at baseline and the follow-up MRI scan (i.e. “MRI interval” in the formula).The secondary efficacy measure was the percentage of change in cognitive outcomes. Clinical and cognitive measures were the ADAS-COG-MCI, MMSE, Isaacs’s verbal fluency and lexical fluency tests (15- and 60-item versions), TMT-Part A and B, and the Benton test, as in the original Hippocampus Study design [