Baseline demographics and clinical characteristics
DISEASE, EVENT, BEST
Between October 4, 2018 and August 27, 2020, 75 patients from 16 UK hospitals were recruited to Cohort E. 60/75 (80%) of patients had no mutation identified in ctDNA testing and 15/75 (20%) patients had ctDNA mutations (9 Patients and characteristics.


Further details regarding study population and geographical location are provided in Supplementary Tables S1–S3.Of the 75 patients entering Cohort E, 70 were evaluable for response; 3 patients never started treatment, 1 had no RECIST measurable disease at baseline and 1 patient did not have any post baseline RECIST scan data (Supplementary Fig. S1). The ORR (excluding unconfirmed responses) was 12/70; 17.1% (UMVUE = 18.1%; 95% CI, 10.4%–25.5%). All confirmed responses were in the first 69 evaluable patients. Median duration of response for the 12 patients who had confirmed CR/PR was 9.1 months IQR (6.0–11.5). Five patients with confirmed response were still on treatment at the time of the snapshot (Best percentage change from baseline for sum of the target lesions (Swimmer plots for evaluable population with (In a The clinical benefit rate was 21/70: 30% (exact 95% CI, 19.6–42.1). At a median follow-up of 18.3 months (IQR, 13.9–23.4), 59/75 (79%) patients had a PFS event with median PFS 4.3 months (IQR, 1.9–10.0 months; Supplementary Fig. S2) and 45 (60%) patients had died. To examine long-responders, an additional snapshot was taken on June 22, 2023, when 3 patients remained on treatment, with 48.6 (