Certification of disulfidptosis-related genes (DRGs) in PCa
MYH10
In total, we obtained 15 DRGs from Liu's study, including FLNA, FLNB, MYH9, TLN1, ACTB, MYL6, MYH10, CAPZB, DSTN, IQGAP1, ACTN4, PDLIM1, CD2AP, INF2, and SLC7A11(the gene set consists of the key gene for disulfidptosis, SLC7A11, and the genes most strongly associated with disulfidptosis). The expression and copy number variation (CNV) data of these 15 DRGs were extracted and the frequency of CNV was calculated based on the proportion of amplifications and deletions in CNV. Differential analysis of DRGs and Kaplan–Meier survival analysis were performed using the “limma” R package and the “survivor” R package. 12 DRGs with both expression and survival differences in PCa were identified by taking the intersection using the “VennDiagram” R package.