Conclusions
DFS, Dukes’ B2, B3, and C colon cancer
METASTASIS
The optimal timing of adjuvant chemotherapy following curative colon resection is unknown. Preclinical data and kinetic modeling suggest that surgery can potentiate metastasis and support the notion of initiation of systemic treatment as early as possible. This randomized trial compared perioperative infusional 5-FU for 7 days starting within 24 h of resection with a control group that did not receive perioperative 5-FU. Perioperative 5-FU was well tolerated and did not adversely affect wound healing. This multi-institutional trial was terminated early for slow accrual and found no statistically significant difference in OS or DFS among patients with Dukes’ B2, B3, and C colon cancer.