Author contributions
JC. Pastor and R.Coco designed all experiments. JC.Pastor, R. Coco and S.Pastor-Idoate, M. Para, M. López-Paniagua, F. Blazquez and E. Murgui performed the experiments, analyzed the data, and summarized the results. JC. Pastor, S. Pastor-Idoate and R.Coco performed the experiments. M. López-Paniagua, M. Para, F. Blazquez and E. Murgui, supervised the experiments. JC. Pastor, S. Pastor-Idoate and R. Coco wrote the manuscript. All authors have read and approved the final manuscript. V. García provided information about the advanced therapy product.