Author contributions
These authors jointly supervised this work (as recruiting investigators and being involved in study design and data interpretation): M.K., R.C.C., S.H., S.L., and R.J. These authors contributed equally (as recruiting investigators): L.K., J.Ma., Z.M., C.P., L.C., P.R., W.G., S.S., J.Me., J.O., P.W., P.C., T.A., R.B. The following author was a preclinical scientist involved in data interpretation: S.A. The following authors are Carrick employees and were involved in the study design and data interpretation: G.C., A.B., S.M.