Changes from baseline across subgroups
CML-CP
CML
Changes from baseline in CML symptoms, interference in life, and HRQOL observed across specific subgroups of patients (based on sex, race, age, reason for prior TKI discontinuation, and number of prior TKI lines of therapy) were largely consistent with the results observed for the overall population in ASCEMBL across all PRO questionnaires. A trend for improvement in symptom severity from baseline in favor of asciminib was observed for CML-CP patients, regardless of whether prior TKI therapy was discontinued due to TKI failure or intolerance, though the trend toward improvement in HRQOL from baseline in favor of asciminib was greater for those with prior TKI failure (data not shown).