Monte Carlo simulations.
Using the above-described population PK model (Average 24-h total-drug plasma and ELF AUC values on days 1 and 2 were calculated by numerical integration of the total-drug plasma concentration curves from 0 to 48 h and then division of the resulting AUC by 2. Additionally, 24-h total-drug plasma AUC values were determined after the p.o. switch on day 3 for i.v.-to-p.o. dosing regimens. Total-drug plasma AUC values were adjusted to free-drug plasma AUC values using a free fraction of 0.79 based on Free-drug plasma and total-drug ELF AUC values for each simulated patient were divided by MIC values, the range for which was determined based on the observed 