INTRODUCTION
sepsis, deaths, liver disease
SEPSIS, DISEASES, LIVER DISEASE, SPONTANEOUS BACTERIAL PERITONITIS
There has been an epidemic of liver disease during the past 50 years in the United Kingdom, with a 4-fold increase in liver-related deaths (Other clinical trials of albumin infusion have shown conflicting results. For instance, a meta-analysis of albumin use in patients with spontaneous bacterial peritonitis reported significant benefit (Healthy individuals show a high degree of functional connectivity between physiological organ systems. Disruption of organ system coupling is a hallmark of complex diseases, and recent studies showed that reduced network connectivity was linked with poor survival in patients with sepsis (Targeted albumin infusion has the potential to challenge the physiological network through alteration of oncotic pressure, plasma volume, glomerular filtration rate (GFR), and transportation of various physiological molecules. Therefore, the assessment of physiological interaction as a network may allow for a more precise prediction of patients' response or outcome. The parenclitic network mapping allows network analysis of static, baseline clinical variables on the individual patient level (