INTRODUCTION
cancers, tumor necrosis, cancer, inflammation, deaths, prostate cancer
OVARIAN CANCER, CANCERS, TUMOR NECROSIS, CANCER, INFLAMMATION, PROSTATE CANCER
Despite the continuing decline in the incidence of ovarian cancer, it still accounts for 2.5% of all female cancers diagnosed and 5% of all cancer‐related deaths among women in the United States.Numerous observational studies have shown that exercise following diagnosis is associated with a lower mortality risk in breast, colorectal, and prostate cancer survivorsSeveral mechanisms have been suggested for the observed association between exercise and reduced mortality risk in patients with cancer including the effect of exercise on (a) body fatness (whole‐body and visceral); (b) adipokines, such as leptin; (c) low‐grade inflammation which can be evaluated via serum C‐reactive protein (CRP); and (d) metabolic dysregulation which can be evaluated for example by serum insulin and insulin‐like growth factor‐1 (IGF‐1).In addition to the above prespecified cancer‐related biomarkers, several exploratory cancer‐related biomarkers were examined in this study. The inflammatory markers interleukin 6 (IL‐6) and tumor necrosis factor alpha (TNFα) were included as inflammation may play a role in cancer recurrence and mortality.The Women's Activity and Lifestyle Study in Connecticut (WALC) was a 6‐month randomized controlled trial of aerobic exercise versus attention‐control in women with ovarian cancer.