Study assessment
Clinicians will inform all the patients enrolled in the study that their biological samples could be used for research purposes and will obtain informed consent from the participants. All participating donors may object at any time, leading to the disposal of their tissues and any derived material, as well as the cessation of data collection. The enrollment period of the study will be 3 years; each patient will be monitored for 3 years and study duration will be 6 years.