2.11. miRNA
Sixteen (16) liver specimens from 16 patients were used for miRNA differential expression analysis. First, we looked at differential expression between lesion response groups. Thirteen (13) of the 16 lesions profiled for miRNA had evaluable response lesions; 5 were SD, 4 were ARES, and 4 were IRES. Overall, a small number of miRNAs (n = 5) are differentially expressed in stable lesions compared to resistance lesions. Specifically, miR-365a-5p, miR-6510-3p, and miR-934 were found to be under expressed in SD in comparison to ARES or IRES, while miR-9-5p and miR-204-5p are overexpressed in SD relative to ARES or IRES. Lesions with intrinsic and acquired resistance have similar expression profiles for these miRNAs (