Subjects and study design
T2DM
SECONDARY
This investigation is a secondary analysis of a 1-year randomized crossover trial conducted in individuals with T2DM that aimed to compare the effect of different exercise intensities on glycated hemoglobin as the main outcome. A total of 80 participants with T2DM completed baseline assessments and were allocated to one of three arms: (1) high-intensity interval cycling combined with resistance training (HIIT); (2) moderate-intensity cycling combined with resistance training (MICT); (3) control group. Sample size calculation procedures were based on a predicted glycated hemoglobin difference of 0.66 units, with a standard deviation of 1.2 units (α, 0.05; 1 − β, 0.80) and an expected dropout rate of 10% (Fig. Study flowchart