DISCUSSION
infection, biofilm infection, WED
SCARRING, WED, INFECTION
In this prospective, randomized, controlled clinical trial, we have shown that early, short-term treatment with WED significantly decreased biofilm severity in burn wounds (Summary graphic. In this study, patients with burn wounds admitted to the Brooke Army Medical Center (San Antonio TX), were subject to short-term (7 days) treatment with a WED. WED was more efficient in inhibiting biofilm infection compared with standard of care. Proposed mechanisms of action are described in prior publications from this group. The images were purchased and used per standard agreement policy from iSTOCK.com.The product is also registered and being commercialized in several countries outside the United States. Calibrated approaches are needed to test alternatives to SoC such that room is made for product innovation while not adversely affecting patient safety. An important consideration when designing this study was whether SoC treatment should be withheld while subjects were enrolled.Secondary data (There are a few studies that have used Procellera™ in various clinical study settings but not in the context of biofilm infection. Most of these have been in the context of wound healing, scarring, and patient outcomes from patients undergoing skin graftingThis study investigates the effect of WED on biofilm and that is not a current indication under FDA clearance. This work corroborates the anti-biofilm efficacy of WED in burn wounds and supports the safety of use in the context of human subjects. A larger clinical trial with longer duration of treatment investigating the impact on wound healing outcomes in relation to biofilm infection management is warranted.