Translational research program
tumor
TUMOR
Within this trial, a comprehensive translational research program is implemented to improve our understanding of the pathogenetic factors that drive lymphomagenesis and to establish innovative biomarkers that improve risk stratification and outcome prediction. We will comprehensively explore tumor biopsies to characterize molecular subgroups of patients with certain (epi-)genetic alterations. Additionally, we will apply targeted next-generation sequencing to circulating tumor DNA (ctDNA) obtained from blood plasma and cerebrospinal fluid (CSF) throughout the treatment course to investigate its role as prognostic biomarker (Fig. 