Outcomes
ASYMPTOMATIC COVID-19
The primary efficacy endpoint was the laboratory-confirmed symptomatic COVID-19 that occurred during the case monitoring period between 24 h after the first administration and 24 h after the last administration of SA58 or placebo. COVID-19 case was defined based on symptoms (see Supplementary Table 1). Severe COVID-19 was defined based on the Protocol for Prevention and Control of COVID-19 (9th edition) issued by the National Health Commission of the People’s Republic of China, and we arbitrarily defined severe COVID-19 as severe case and very-severe case combined (see Supplementary Table 2) [