Exploratory endpoints
Key exploratory endpoints included (1) the change from baseline at week 78 in the ADAS-Cog13, MMSE, ADCS-ADL and FAQ scores; (2) the change from baseline in the CSF levels of unbound N-terminal tau; (3) the change from baseline in tau levels as measured by CSF testing (that is, t-tau, p-tau181) and tau PET; and (4) the change from baseline in brain volume as measured by MRI.