NAbs against omicron BA.4/5 subvariant pseudovirus
The GMTs of NAb against omicron BA.4/5 pseudovirus in the low-dose and high-dose aerosolised Ad5-nCoV groups were 149.58 (95% CI 101.03, 221.45) and 158.52 (95% CI 111.36, 225.66) at day 28, 117.47 (95% CI 83.65, 164.96) and 112.53 (95% CI 83.77, 151.16) at month 3, 65.50 (95% CI 48.31, 88.81) and 56.80 (95% CI 41.65, 77.46) at month 6, 40.97 (95% CI 30.15, 55.67) and 35.08 (95% CI 26.31, 46.77) at month 12, respectively. Compared with 28 days, in the low-dose and high-dose aerosolised Ad5-nCoV groups, the GMTs of NAb against omicron BA.4/5 pseudovirus decayed by 21.47% and 29.01% at month 3, 56.21% and 64.17% at month 6, 72.61% and 77.87% at month 12, respectively. In the CoronaVac group, GMTs of NAb against omicron BA.4/5 pseudovirus were below the lower limit of detection at all the time points (Neutralizing antibodies against omicron BA.4/5 pseudovirus after a booster vaccination. Horizontal bars show GMTs and error bars show 95% confidence intervals. Data (folds) above the bars are the NAb GMT ratios of the homologous boost group to the heterologous boost group. Long lines connecting the GMTs of adjacent groups indicate trends in neutralizing antibodies over days after a booster vaccination. Data (%) above the bars show the percent reduction in GMTs of NAb titres at day 90, day 180 and day 360 post-boost compared to day 28. All horizontal dotted lines denote the cutoff levels for positivity (1:30). Data below the cutoff level were assigned half the limit. GMT = geometric mean titre in serum. NAb = neutralizing antibody.GMT, seropositivity rate, and GMT ratio of neutralizing antibodies to omicron BA.4/5 subvariant pseudovirus after a booster vaccination.Notes: Data are GMT (95% CI), seropositivity (%, 95% CI), GMT ratio (95% CI). GMT = geometric mean titre. Seropositivity (%): The proportion of participants whose antibody titres was defined as a detectable neutralizing antibody titre ≥1:30. Data below the cutoff level were assigned half the limit. *The 