Background
infections, CR-GNB
INFECTIONS
The increasing prevalence of multi-drug-resistant bacteria causes high attributable mortality, which is partially due to a lack of effective therapeutic drugs [Polymyxin B is the most commonly used polymyxin in China. However, the clinical regimen is yet to be standardized. Some studies have shown that the dosage of polymyxin B is lower than recommended in the guidelines and that doctors prefer to use a fixed daily dose of 50 mg or 75 mg every 12 h, which might not be according to TBW but it can be implemented easily and avoids wastage. Additionally, some patients did not receive the polymyxin B loading dose [In this study, we conducted a randomized trial to explore the appropriate clinical administration regimen of polymyxin B for the treatment of severe infections caused by CR-GNB. Also, TDM was used to explain the polymyxin B dose–response correlation and determine the optimal dosage.