The OPTIMIZE trial
The OPTIMIZE trial is being conducted in three health care systems in two geographic locations: Salt Lake City, UT, and Baltimore, MD [As a CER study, OPTIMIZE is intended to reflect and inform real-world care delivery using mostly pragmatic methods [PRECIS-2 scoring wheel for the OPTIMIZE study. This is a visual representation of pragmatism of the trial on the explanatory–pragmatic continuum from the original study protocol publication [