Participants
Healthy participants aged 18 to 65 years with a body weight between 45 and 110 kg were eligible for inclusion in this study. Participants were required to be in good health, as determined by the investigator review of medical history, physical examination, vital sign measurements, 12-lead electrocardiogram, and clinical laboratory tests.Key exclusion criteria included hemoglobin (Hb) levels < 12 g/dL, use of prescription drugs or herbal remedies within 14 days of day –1 (except for hormonal contraceptives and some other medications at the discretion of the investigator and/or sponsor), and the use of over-the-counter medications within 7 days of day –1. Medications such as paracetamol and nonsteroidal anti-inflammatory drugs and routinely taken dietary supplements were allowed at the discretion of the investigator and/or sponsor.