Sample size
For sample size calculation, G* power statistical software (version 3. 1. 9. 2; Franz Faul, Universitat Kiel, Germany) was used based on the primary outcome (fibrinogen). The power calculation was done as a comparison between two groups (experimental versus control) according to the independent t-test to gain 80% power, 95% confidence interval, alpha = 0.05, and an effect size of 0.537 was obtained from a 20-subject pilot study. To allow for an expected 10% dropout, the appropriate required sample size for the study was n = 76.Shapiro–Wilk test data distribution was determined using statistical analysis software (SPSS version 25, Armonk, NY: IBM Corp), and continuous data were expressed using mean ± standard deviation (SD). Both dependent and independent sample t-tests were utilized to compare variables within or between experimental and control groups for comparison before and after the study was completed (with statistical significance for 