2.5. Data Analysis
NRI
BONE LESION, RECURRENCE, METASTASES
Cholesterol, albumin, glycemia, LDH, NLR, NLRAR, HALP, PLR, PNI, and NRI values at baseline and 3 months after SBRT were evaluated grouping patients according to ADT administration (ARM A vs. ARM B), biochemical recurrence (BCR) (yes vs. no), and site of metastatses (at least one bone lesion vs. lymphnode(s) only). Additionally, cholesterol, glycemia, testosterone, and LDH at 1 year were evaluated grouping patients according to ADT administration (ARM A vs. ARM B). Changes in these parameters between baseline and 3 months/1 year after SBRT were evaluated and significant differences in these parameters according the above-mentioned stratifications were assessed using the non-parametric Wilcoxon rank-sum test (Mann–Whitney To identify possible prognostic biomarkers, differences in the considered parameters were investigated at baseline, also, grouping patients according to the presence of BCR. Furthermore, patients were divided according to quartiles of the distribution of the time from surgery to oligorecurrence to assess any impact of this interval on the change in CONUT score. Correlations among biomarkers are measured through Spearman correlation coefficients, which are “joined” in a graphical representation to create a network, both at baseline and 3 months after RT, stratifying patients according to treatment arm and site of metastases. In the network, nodes represent individual biomarkers, while Spearman correlation coefficients between biomarkers are depicted as edges (lines connecting nodes). The color spectrum of the edges ranges from green (direct correlation) to orange (inverse correlation). The thickness of the edges indicates the strength of the association. The position of a node reflects its centrality or rather the importance of a node within the network. All the analysis were performed with R Studio software (R version 4.1.1 R Core Team (2020). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria).