Methods
REGRESSION, LENS
Methods for Protocol AB (ClinicalTrials.Gov identifier: NCT02858076) have been reported elsewhere [The Work Productivity and Activity Impairment Questionnaire was used to measure the overall percentage of activity impairment due to VA (a scale from 0% to 100% indicating the level of impairment in performing everyday activities with higher values indicating greater impairment) and work productivity loss (a combination of work time missed and impairment while working) during the prior 7 days leading up to the day on which the questionnaire was administered [Linear regression using the robust sandwich estimator for the variance was used to estimate the treatment group difference and corresponding 95% confidence interval (CI) with adjustment for baseline score (activity impairment or work productivity loss) and lens status per the prespecified statistical analysis plan [