Statistical analysis
death
CARDIAC EVENTS, SECONDARY
Descriptive statistics were used to summarize the primary outcome, CRP, as well as secondary outcome measures by treatment group. Due to the primary outcome having a non-normal continuous distribution (as well as other continuous secondary outcomes), data was reported as medians and interquartile ranges for continuous variables rather than means and standard deviations. The primary analysis utilized the Wilcoxon-Mann–Whitney test to compare the difference scores of CRP (day 6 vs baseline measure) by treatment groups. Further analysis compared secondary outcome measures (lactate dehydrogenase U/L, D-dimer mg/mL, and interleukin-6 pg/mL) between treatment groups in a similar manner and utilized the Fisher’s Exact Test to compare the dichotomous safety outcome measures (death, intubation, ECMO, and major cardiac events) between treatment groups.Descriptive statistics on patient demographic factors and hospital stay/admission characteristics were generated by treatment group as well as standardized difference scores (difference in means or proportions divided by standard error) to assess the balance between treatment groups at baseline.