Subjects
Cancer
CANCER
Sera were obtained over the course of the MGTX study (NS 42685). On day of collection blood was shipped by overnight delivery in chilled containers for immediate processing to the National Cancer Center in Frederick, Maryland where it was immediately processed to sera, which was maintained at -80° C until being thawed for metabolomic analysis. Subjects were between 18 and 65 years old with generalized MG for less than 5 years and elevated serum AChR antibody levels. All subjects received a standardized prednisone escalation and taper, which required subjects to have an improvement of QMG or a score less than 14. The prednisone dose over time (area under the curve analysis) at 6 months was not different between thymectomy plus prednisone versus prednisone alone groups [