Backgrounds
cancer, HSV-seropositive allogeneic HSCT recipients, fever
ORAL MUCOSITIS, SIDE EFFECT, CANCER, CNS INFECTIONS, BLOOD
Chemotherapy-induced oral mucositis (CIOM) is a significant side effect of chemotherapy in cancer patients. A significant correlation was found between a 1-point increase in the oral mucositis score and several adverse outcomes, including more days with fever, parenteral nutrition, hospitalization, and higher mortality at 100 days in patients undergoing chemotherapy [The Center for International Blood and Marrow Transplant (CIBMTR) guidelines for the prevention and treatment of infections in hematopoietic stem cell transplantation (HSCT) recipients clearly and strongly recommend the use of the antiviral agent acyclovir to HSV-seropositive allogeneic HSCT recipients during the preengraftment period to prevent HSV reactivation based on good quality of evidence (level AI from the evidence-based rating system) [Based on this background and the results of our previous work [