DISCUSSION
exacerbations, inflammation, COPD exacerbations, bronchial asthma, COPD
DISEASE PROGRESSION, INFLAMMATION, COPD EXACERBATION, COPD, BRONCHIAL ASTHMA, CHRONIC INFLAMMATION, OXIDATIVE STRESS, PATHOGENESIS
The occurrence of COPD is determined by both environmental and genetic factors, and it is closely related to chronic inflammation, oxidative stress, imbalance of protease and antiprotease, apoptosis, and so on. The pathogenesis and pathological changes of the condition are complex and heterogeneous.In this prospective cohort study, patients with the clinical subtypes of neutrophilic and eosinophilic COPD who were treated with doxofylline in addition to an inhaled bronchodilator were found to be less likely to have severe exacerbations than patients treated with the inhaled bronchodilator only. Graham Devereux previously found that patients with bronchial asthma experienced the greatest benefit after using doxofylline for 6 weeks, whereas patients with COPD observed the greatest benefit from the eighth week.Among the neutrophilic subtype, the mean number of patients with exacerbations was lower in the DG than in the NDG in the third month after discharge (6.6% vs. 22.4%), showing a 15.8% reduction in the risk of severe exacerbations. In the sixth month after discharge, a 13.2% reduction was seen (3.9% vs. 17.1%). Among the eosinophilic subtype, the mean number of patients with exacerbations was lower in the DG than in the NDG in the sixth month after discharge (0.0% vs. 14.8%), showing a 14.8% reduction in the risk of severe exacerbations. According to the current trial, theophylline can reduce the number of severe COPD exacerbations requiring hospital admission, with the most benefit being evident in the subgroup of those patients frequently hospitalized with COPD.COPD is a condition involving chronic inflammation of the airway that always occurs repeatedly and develops progressively, resulting in the remodeling of the airway structure and the destruction of the alveolar structure. It has been found that the main airway cells involved in the inflammation include activated neutrophils, macrophages, eosinophils, and lymphocytes.In the current study, 125 of the participants were treated with inhaled drugs containing glucocorticoid during the 6‐month follow‐up period. In the sixth month, there was a significant difference between the dose adjustment rates of inhaled drugs containing glucocorticoid for the DG and the NDG (20.0% vs. 16.0% reduced, 4.8% vs. 15.2% increased; Pulmonary function is an important and intuitive index for measuring airflow limitation with good repeatability. It has great significance in the diagnosis, severity evaluation, disease progression, prognosis, and treatment response of COPD.Drug safety is one of the core issues in the treatment of COPD. Theophylline is mainly metabolized through the cytochrome P450 microsomal enzyme system of CYP1A2 in the liver.