2.6. Primary Outcome
AMS
The evaluation of AMS score via questionnaire was set as a primary outcome of the study. The AMS questionnaire was completed at the first visit (week 0), second visit (6th week), and third visit (12th week). The questionnaire included a total of 17 items and 3 sub-domains: mental symptoms (5 items), physical symptoms (7 items), and sexual symptoms (5 items). Each item was rated on a Likert 5-point scale, with higher scores indicating more severe symptoms. A score of 17–26 indicates no symptoms, a score of 27–36 is mild, a score of 37–49 is moderate, and a score of 50 or more indicates high severity [