Interventions
ulcer, ulcers, RAU
ADVERSE REACTIONS, ULCERS, ULCER
The subjects were randomly placed into one of the three interventions: 0.1% CBD, 0.1% TA, or placebo. Seventy-two subjects (24 subjects for each intervention) were enrolled in this study. The interventions were applied with a provided calibrated spoon to the ulcers 3 times/day after meals for 7 days. When the subjects developed RAU more than one time (at least 2 weeks apart), they could reenter the study, and received a different topical intervention. Each subject was interviewed at each visit by the same investigator regarding the emergence of any adverse reactions. The ulcers were diagnosed by an oral medicine specialist. If there was more than one ulcer, the ulcer with the easiest access was selected for investigation.