Recommendations
The choice between different summary measures should be driven first by clinical considerations. Power considerations should only determine choice of summary measure among summary measures that are acceptable clinically.All assumptions and analysis methods being equal, it is advisable to choose the most powerful summary measure. This is often the DRMST, provided it is estimated under proportional hazards.Whenever the proportional hazards assumption is likely to hold, reflecting it in the analysis is recommended in order to maximise power.