Response
PK/PD
Day 28 PCR-adjusted ACPR was achieved by 94.4% (34/36) of patients who had an estimated AUC for both artefenomel and ferroquine above the median value, 92.0% (23/25) of patients when only exposure to artefenomel was above its median value, 88.0% (22/25) when only ferroquine exposure was above its median value, and 77.1% (27/35) when exposure to both drugs was below the median value (Fig. Graphical representation of Day 28 PCR-adjusted ACPR compared with ferroquine and artefenomel exposure. PK/PD efficacy population. Dotted lines represent median exposure in the PK/PD efficacy population for each drug