Lack of benefit during vitamin C administration
sepsis, Urgency, organ dysfunction
SEPSIS
The motivation for our paper was to challenge the LOVIT authors’ conclusion that it was the intravenous vitamin C that caused the higher risk of mortality or persistent organ dysfunction in the vitamin group [In a recent retrospective cohort study conducted in Korea using propensity score matching, vitamin C administration was associated with lower mortality in sepsis patients who were treated for ≥5 days, but it was ineffective when treatment was shorter [Another potentially relevant issue is the delay of vitamin C initiation. Urgency is important in the treatment of sepsis [Finally, mortality is not the only important outcome in the ICU context. In our view, the 862 patient LOVIT trial does not refute the significant effect of vitamin C on the length of stay in ICU found in the meta-analysis which combined 12 trials with 1766 participants [