Materials and methods
This parallel, two-group, randomized controlled trial evaluated the non-inferiority of a PSD optimized iCBT guided by a digital coach (IG) or a human coach (CG). This trial was a-priori registered at the WHO International Clinical Trials Registry (ID: DRKS00025209; 30/04/2021), approved by the ethic committee of Ulm University (Number 502/20) and was conducted and reported according to the extension of the CONSORT 2010 Statement for non-inferiority and equivalence trials [