Lipidomic Risk score building
T2DM
REGRESSION
We performed a Cox proportional hazards regression analysis with the 15 lipids selected by RSF in the Training set to determine the potential use of these lipids as an independent predictor of T2DM development. Next, a LR Score was built by multiplying the coefficients obtained for every lipid in the previous step (the Cox analysis) by its plasma concentration. This LR Score was built into both the Training and the Validation set. Furthermore, patients were classified according to the score generated to carry out a second Cox proportional hazards regression with each one of those variables, adjusted by diet, age, gender, body mass index (BMI), HDL, TGs, and statin intensity treatment. Finally, the predictive capacity of this score was evaluated by classifying the same population with different cut-off points.