Trial population
heart failure, ischemic heart disease
TORSADE DE POINTES, HEART FAILURE, ISCHEMIC HEART DISEASE, HEART
Male and female patients aged 18–80 years with a body weight of 50–110 kg and a current episode of symptomatic AF lasting between 3 h and 7 days were deemed eligible. Patients were required to be treated with anticoagulation according to current guidelines. Patients were allowed to have stable ischemic heart disease and heart failure (New York Heart Association classes I and II, left ventricular ejection fraction 40% or higher). Exclusion criteria included recent cardioversion, current or recent use of antiarrhythmic drug classes I or III (including amiodarone), QTcF greater than 450 ms or previous torsade de pointes episodes. The complete list of inclusion and exclusion criteria can be found in the next sections.