Discussion
hypertension, organ damage
CARDIOVASCULAR DISEASE, ESSENTIAL HYPERTENSION, ESSENTIAL HYPERTENSION, EVENT, ELEVATED BLOOD PRESSURE, HYPERTENSION
Essential hypertension is featured with persistently elevated blood pressure levels, which in turn results in target organ damage together with an enhanced risk of cardiovascular disease [The activation of inflammatory pathways is a crucial pathological event in hypertension development [In our work, we found that HMG-CoA reductase inhibitor improved blood pressure levels, lipid levels, serum inflammatory factor levels and cardiac function in elderly patients with essential hypertension. Many previous studies coincide with the results of our article. For blood pressure, statin treatment in combination with antihypertensive treatment decreases blood pressure in contrast to antihypertensive treatment combined with a hypocholesterolemic diet [Also, our research signified that both HMG-CoA reductase inhibitor and AG490 improved blood pressure levels, lipid levels, serum inflammatory factor levels and cardiac function in SHR rats. Besides, both HMG-CoA reductase inhibitor and AG490 decreased p-JAK2/JAK2 and p-STAT3/STAT3 expression levels. In a bleomycin-induced PH animal model, p-JAK2/p-STAT3 is found to be upregulated and localized in pulmonary arteries [In summary, our study underscores that HMG-CoA reductase inhibitor improves elderly essential hypertension-induced vascular endothelial function impairment by blocking the JAK/STAT pathway. HMG-CoA reductase inhibitor, especially atorvastatin, could act as a suitable therapy for essential hypertension in elderly patients, and and JAK/STAT inhibition might be promising in patients with hypertension. Nevertheless, further experiments are necessary for the validation of our findings.