Acknowledgements
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The authors thank the patients, nurses and data managers who participated in this study. Emilio Bria is currently supported by Fondazione Associazione Italiana per la Ricerca sul Cancro (AIRC) under Investigator Grant (IG) no. IG20583. Emilio Bria is supported by Institutional funds of Università Cattolica del Sacro Cuore (UCSC-project D1).