Study design
non-obese, PCOS
The study population consisted of 72 non-obese adolescent girls with PCOS belonging to the above described clinical trials [n=17 and n=17 receiving PioFluMet and EE-CA respectively; n=18 and n=20 receving SPIOMET and EE-LNG respectively); mean age, 16 years; mean BMI, 23 kg/mTwenty-eight age- and BMI-matched healthy girls recruited from nearby schools served as controls. All had regular cycles, were non-hirsute, and had normal serum glucose, lipids and androgens.The PioFluMet study (ISRCTN45546616) and both SPIOMET studies (ISRCTN29234515 and ISRCTN11062950) were conducted after approval by the Institutional Review Board of Sant Joan de Déu University Hospital, after written consent by parents, and assent by each of the study girls, including the healthy controls who allowed to derive indicative values.