Strength and limitations
The preventive effect of chlorhexidine-impregnated cloths presented here is based on a post-hoc before-after analysis. The a priori analysis of this cRCT found no significant differences of CLABSI rates between the intervention groups (chlorhexidine and octenidine group) and the control group during the intervention period [Further, potential confounders including insertion site or usage of ultrasound guidance for central line insertion could have an impact on CLABSI rates [