Background
sarcoma, tumour, colorectal cancers
SARCOMA, COLORECTAL CANCERS, RECTAL CANCER, TUMOUR
The standard treatment for locally advanced rectal cancer (LARC) is neoadjuvant treatment followed by total mesorectal excision (TME) [Kirsten rat sarcoma (KRAS) mutation, occurring in 30–40% of colorectal cancers [Invasive pathological examination is usually conducted to detect KRAS status. However, sufficient and high-quality tumour tissue samples for KRAS detection may be difficult to obtain due to poor tolerance for invasive procedures and intratumoral heterogeneity. To reduce invasive procedures and avoid repeated sampling, several trials have aroused interest in assessing KRAS status through noninvasive strategies. Radiomics, which converts imaging information to quantitative features, has been developing rapidly in recent years to improve diagnosis, identify genotypes and predict prognosis in rectal cancer [