Subjects
SAD
RECRUITMENT
Subjects were recruited through recruitment advertisements. A total of 487 healthy subjects from various communities in China underwent screening; 343 for SAD, 96 for MAD, and 48 for FE arm (Fig. Flow chart of study. Forty-four volunteers received AD16 in the 5 mg to 60 mg dose group of SAD. FAS, full analysis set; PKS, PK analysis set; SS, safety analysis set; FES, FE analysis setThe eligible population consisted of healthy Chinese males and females weighing ≥ 50 kg or ≥ 45 kg, respectively, aged 18–45 years, and having a body mass index (BMI) of 19–24 kg/m