DISCUSSION
breast
cancer
CAVITY, BLIND
The results of our study showed that the mean endometrial thickness of patients in
the TMX group was 8.72±1.45 mm and in the HRT group it was
9.00±1.69mm, and this difference was not statistically significant. These
findings suggest that tamoxifen and gonadotropin can be effective for endometrial
preparation in frozen embryo transfers. Our study showed no significant difference
in clinical pregnancy rate, biochemical pregnancy rate, ongoing pregnancy and
implantation rate between the two groups.Tamoxifen is a selective estrogen receptor modulator (SERM) used to treat breast
cancer (To date, there have been a few studies on the treatment of thin endometrium in frozen
fetal cycles with tamoxifen in the literature. For the first time, Ke Ji The inconsistency between our findings and these studies might have resulted from
variations in design, methods and our sample population. Similar to other studies,
we have not seen any serious side effects in the participants. In our study, some
cycles were canceled due to the non-triple line pattern of endometrial or fluid
buildup within the endometrial cavity, which had not been reported in previous
studies. The possible explanation for these results may be due to the difference in
drug dose between the studies. We used a higher dose of the TMX in comparison to
similar studies. However, further research should be undertaken to investigate the
appropriate dose of TMX in FET cycles.To the best of our knowledge, the present study appears to be the first randomized
clinical trial study to compare the endometrial thickness and pregnancy outcome
between TMX and hormone replacement treatment in FET. However, our study has some
limitations; first, we didn’t examine any subset of patients who did not have a
mature follicle separately. This may have affected our results. In addition, we
couldn’t blind the patients and this might put the result at a risk of bias.