Patients
Tumors, gastric adenocarcinoma
TUMORS, GASTRIC ADENOCARCINOMA
Patients with histologically confirmed gastric adenocarcinoma and radiographic diagnosis of locally advanced or metastatic GC were eligible for inclusion. Other inclusion criteria included age of ≥ 18 years old, measurable and/or evaluable lesions according to the Response Evaluation Criteria in Solid Tumors (RECIST) guideline version 1.1, ECOG PS score of < 2, ability to take medications orally, no previous palliative chemotherapy (adjuvant chemotherapy or neoadjuvant chemotherapy with interval of ≥ 6 months was allowed), time since last radiotherapy treatment of ≥ 3 weeks, expected survival period of ≥ 3 months, and no severe lung, heart, or any other comorbidities. The following conditions for blood test examinations had to be satisfied within 14 days before enrollment to verify proper organ function: white blood cell count of (3.0–10.0) × 10