Liver tests, hepatic fat fraction, and fibrosis markers
NAFLD fibrosis, liver stiffness, fibrosis
LIVER FIBROSIS, FIBROSIS
In the TXR and combination groups, a decrease in ALT (Figure Geometric mean percentage change from baseline (95% CI) up to week 48 in all groups and change in hepatic fat fraction at weeks 24 and 48. (A) Geometric mean percentage change (95% CI) in ALT; (B) geometric mean percentage change (95% CI) in AST; (C) geometric mean percentage change (95% CI) in GGT; (D) geometric mean percentage change from baseline in hepatic fat fraction; and (E) patients with at least a 30% reduction in hepatic fat fraction. Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; CVC, cenicriviroc; GGT, gamma-glutamyl transferase; HFF, hepatic fat fraction; n, number of patients in group; TXRThere were no consistent changes from baseline to week 48 for liver stiffness (via Fibroscan), enhanced liver fibrosis scores, fibrosis biomarker test scores, NAFLD fibrosis scores, or magnetic resonance elastography-derived liver stiffness from baseline to week 48 with any TXR-containing dose. At week 48, although there was a slight reduction in post-treatment mean fibrosis-4 (FIB-4) from baseline (change from baseline: −0.02) in the TXR