Subject terms
Necessary and sufficient opioids should be administered for safe and stable anesthesia. However, opioid sensitivity varies among individuals. We previously reported that sympathetic responses to nociceptive stimuli under propofol anesthesia could be predicted by measuring the minimum evoked current of the vascular stiffness value (MECClinical trial registration: Registry, University hospital Medical Information Network; registration number, UMIN000047425; principal investigator’s name, Noboru Saeki; date of registration, April 8, 2022.