Analysis of association between biomarker levels and clinical response
Differences in baseline biomarker levels by clinical response at Week 24 (i.e., response versus nonresponse for ACR20/50, IGA 0/1, and PASI75) were evaluated using general linear model analyses and log2-transformed biomarker levels. Clinical response categorical variable was set as the primary fixed factor. In determining response, participants with missing efficacy data were considered nonresponders (nonresponder imputation). To evaluate the significance of changes in biomarkers from baseline among clinical responders and nonresponders, levels were compared between the specified time point and baseline separately for each clinical response group using general linear model analyses. Visit was set as the primary fixed variable.