Subgroup Analyses
myocardial infarction/coronary artery disease, stroke, asthma, apnea-hypopnea, COPD, diabetes
TRANSIENT ISCHEMIC ATTACK, SLEEP APNEA, STROKE, PARKINSON DISEASE, COPD, CONGESTIVE HEART FAILURE, ASTHMA, ATRIAL FIBRILLATION, HYPERTENSION, DIABETES
To validate the effect of arousal on ventricular repolarization lability and its association with mortality, we investigated the subgroup of men whose QTVi was in the lowest quartile during baseline; that is, considered normal but increased beyond the first quartile during arousal. Men who developed larger QTVi responses during arousal were older; had a higher BMI, lower physical activity, and a history of atrial fibrillation; and were more likely to have severe sleep apnea (Characteristics of the Sample With a Baseline QTVi Within the First QTVi QuartileData are presented as mean ± SD or No. (%). Boldface indicates a Cumulative incident function curves compare the competing risk of cardiovascular and noncardiovascular mortality in the men of the first quartile of baseline QTVi. Group 1 represents men whose QTVi values following arousal onset were still in Q1 (QTVi less than –0.96); Group 2 represents participants whose QTVi shifted to upper quartiles (Q2-Q4) following arousal onset. The P value indicates log-rank test results. HR = hazard ratio; QTVi = QT variability index.All-Cause and Cardiovascular Mortality Risk in Men of the First Quartile of Baseline QTViMultivariable analysis was adjusted for age, history of stroke, atrial fibrillation, myocardial infarction/coronary artery disease, congestive heart failure, transient ischemic attack, diabetes, hypertension, COPD, asthma and Parkinson disease, mean heart rate, mean respiratory rate, physical activity scale for elderly, systolic and diastolic BPs, time of sleep spent below 90% oxygen saturation, BMI, apnea-hypopnea index, arousal index, average corrected QT, arousal burden, and drink and smoking habit. Boldface indicates a 