Methods: 
swelling, Pain
ROOT RESORPTION
A split-mouth study was conducted on 16 subjects (9 males and 7 females; age
range 17-25 years; mean age, 21.85±2.45 years) who required therapeutic
extraction of bilateral maxillary first premolars. After the initial
leveling and alignment, L-PRF plugs were placed in a randomly selected
extraction socket (Experimental Group), and the other side served as a
control (Control Group). Canine retraction was carried out by the activation
of nickel-titanium (NiTi) closed-coil springs delivering 150 g of force. The
rates of canine movement, canine rotation, tipping, root resorption, and
molar movement were assessed at monthly intervals for five months (T0-T5).
Pain, swelling and discomfort accompanying the procedure were assessed using
a Likert scale. 