AUTHOR CONTRIBUTIONS
The work reported in the paper has been performed by the authors unless clearly specified in the text. Kohei Shitara, Mingshun Li and Ming Lei contributed to the conception and design of the study. Tianshu Liu, Yuxian Bai, Xiaoyan Lin, Wei Li, Jufeng Wang, Xiaochun Zhang, Hongming Pan, Chunmei Bai, Li Bai, Ying Cheng, Jingdong Zhang, Haijun Zhong, Yi Ba, Wenwei Hu, Ruihua Xu, Weijian Guo, Shukui Qin, Nong Yang, Jianwei Lu and Lin Shen recruited and/or treated patients and gathered clinical data on efficacy and safety. Mingshun Li analyzed the clinical data, Ming Lei performed biomarker analyses and Tian Chen conducted statistical analyses. Ming Lei, Mingshun Li, Nicole Bao and Tian Chen verified the data. All authors interpreted the data. All authors had access to all the data in the study, participated in developing or reviewing the manuscript and provided final approval to submit the manuscript for publication. The work reported in the paper has been performed by the authors unless clearly specified in the text.