Background
toxicities, AML, cancer, Myeloid malignancies, cognitive impairments, myeloid malignancies
CANCER, ACUTE MYELOID LEUKEMIA, AML, MYELODYSPLASTIC SYNDROME (MDS)
Myeloid malignancies, such as acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), most commonly occur in adults aged ≥ 60 years [Aging is a heterogeneous process, and chronological age does not always accurately represent underlying physiologic age [Older adults with myeloid malignancies are susceptible to treatment-related toxicities. Accelerated DNAm age may be used as a biomarker to predict individuals at risk. In addition, cancer treatment can also lead to accelerated DNAm age through epigenetic alterations [Exercise is a promising intervention to reduce or prevent functional, psychological, and cognitive impairments in older patients with myeloid malignancies [