Study design and participants
allergy, chronic opioid addiction, dementia, infection, nerve block
INFECTION, ALLERGY, DISEASES, COAGULOPATHY
Patients aged 18–85 years who received nerve block before surgery were enrolled. Present study was conducted to investigate the efficacy of remimazolam for procedure sedation with different regimens in the young (aged < 65 years) and elderly (aged ≥ 65 years) patients separately. The two parts shared the same exclusion criteria: (1) nerve block contraindications including local infection, coagulopathy, and abnormal anatomy; (2) allergy to local anesthetics and benzodiazepines; (3) chronic opioid addiction or use of other analgesics for more than 3 months; (4) inability to communicate due to severe dementia, language barrier or end-stage diseases; or (5) American Society of Anesthesiologists physical status of 4 or above.