Discussion
retinopathy, burns, OSAS, acne, depressed scars, trauma
RETINOPATHY, HYPERTROPHIC, SCAR, ACNE, SCAR, DISEASES, SKIN LESIONS
From the introduction of SVF to the present day, numerous therapeutic applications have been reported, including its effective role in the treatment of retinopathy and nerve regeneration [Several studies have been performed on the methods used to treat skin scars [Comparing the results of the present study with similar studies, a study of facial scars caused by trauma or burns conducted by Gentil et al. in Italy in 2014 showed that 63% of scars had healed in the group treated with SVF after one year, compared with 39% in the control group and 69% in patients treated with platelet-rich plasma (PRP) and nanofat [In our study, the additional injection of SVF to fractional COOther studies have been conducted on the performance of fractional COIn other results of this study, only R2 index (scar elasticity) in cutometry improved significantly with laser treatment, but measurement of R0 index (scar firmness) showed no significant improvement [In our study, the efficacy of SVF was also evaluated. There is an evaluation that was not investigated in the above study. In our study, there was no significant difference in the R2 variable in cutometry in patients before and after laser. This difference might be due to the different nature of the study. In contrast to the aforementioned study, our study was a clinical study, whereas the aforementioned study was a systematic review.In a 2019 study conducted in South Korea, Kim and colleagues examined a skin defect on a patient's leg that occurred after an accident. The aforementioned lesion was covered by a skin graft, but the resulting scar was prominent and developed into a hypertrophic scar. In this study, the patient was treated with fractional COIn two separate studies, Lee and his colleagues in South Korea investigated the effect of SVF injection in the surgical treatment of depressed scars. In the first study, 17 patients underwent SVF injection concurrently with surgical scar reduction. In the second study, seven patients underwent scar revision surgery concurrently with SVF injection, and eight patients underwent surgical treatment alone as a control group. The OSAS (Observer Scar Assessment System), SBSES (Stony Brook Evaluation System), VSS (Vancouver Scar Scale), and VAS (Visual Analog Scale) scoring systems were used to evaluate response to treatment. All patients showed significant improvement based on all 4 scoring systems. Patients in the SVF group had a higher cure rate than the non-SVF group on all scoring systems except SBSES. The highest rate of improvement was also seen in scar height and flexibility, whereas a significant change was seen in vascularity [In addition to the above studies, some studies have also investigated the effect of fractional COAnother study by Khan Ali and his colleagues showed that fractional COIn Galal and colleagues' study of 30 patients with acne scars, the two methods of fractional COIn the study by Behrangi et al. performed in 2022 on seven patients with acne scar complaints, all patients were treated with SVF injection in one half of the face, while the other half of the face served as a control group. The results of the evaluation after 3 months confirmed a significant improvement in sonographic variables such as skin thickness and total skin thickness compared to baseline values at the beginning of the study. In contrast, the improvement in the sonographic variable of epidermis thickness was not significant [Finally, it is important to mention that several studies have mentioned the efficacy of SVF in the treatment of various diseases as well as different skin lesions, including burn scars and acne scars [