1. Introduction
VAGINOSIS, DISEASE, BACTERIAL VAGINOSIS, VAGINA
These authors contributed equally to this work.Bacterial vaginosis (BV) is the most common disease in women of childbearing age and is caused by the growth of abnormal microbiota in the vagina. Probiotic consumption can be an effective alternative treatment to preserve or improve vaginal health. In the present study, MED-01, a complex of five strains of probiotic candidates isolated from the vagina of Korean women, was used. This study was designed as a 12-week, randomized, multicenter, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of MED-01 on vaginal health. A total of 101 reproductive-aged women with a Nugent score of 4–6 took MED-01 (5.0 × 10Bacterial vaginosis (BV) is characterized by the depletion of lactic acid bacteria (LAB) and overgrowth of certain anaerobic and facultative bacteria such as Probiotics are now recognized as an alternative or additional treatment method for BV. The World Health Organization defines probiotics as “live microorganisms which, when administered in adequate amounts, confer a health benefit on the host” [MED-01 is a complex that includes five probiotic strains, Therefore, in the present study, a human application test was performed to evaluate the efficacy of MED-01 on vaginal health and safety. Its effects on vaginal health parameters (e.g., vaginal pH and Nugent score) and subjective symptoms such as vaginal discharge and burning sensation were also monitored.