Author contributions
TD
RECRUITMENT
YT, LL, TZ, ZF, SW, TD and MC performed patient recruitment and informed consent. YT, LL, TZ, ZF, SW, TD and MC collected the samples and conducted the tests. YT and ZP analyzed the data. YT, ZP, YC, WW and YB wrote the manuscript. ZP, RY and QL revised the manuscript. QL, RY and BJYL conceived the study. All authors read and approved the final manuscript.