Patients
The study population was retrospectively enrolled SPSNs patients who underwent contrast-enhanced SDCT examination within one month before surgery from our hospital between January 2016 and December 2020. Ultimately, 242 patients (average age 59.90 ± 10.55 years) were included. We collected 6 clinical risk factors including age, sex, smoking, carcinoembryonic antigen (CEA), cytokeratin 19 fragment 21–1 (CYFRA21-1), and neuron-specific enolase (NSE). The final cohort was randomly divided into training (Overview workflow of this study. SDCT, dual-layer Spectral Detector CT; SPSN, solitary pulmonary solid nodule; VMI, virtual monochromatic images