CP redresses gut microbiota dysbiosis in T2DM patients
T2DM
To explore the potential role of the gut microbiota in CP-induced metabolic phenotypes improvement in T2DM patients, 16S rRNA gene sequencing was performed in the fecal samples from the patients on Day 0 and Day 84. At the phylum level, the overall microbial compositions were shown in The abundances of the gut microbiota at the phylum level in T2DM patients. At the genus level, the top 10 dominant genera was presented in The abundances of the gut microbiota at the genus level in T2DM patients. Then we conducted a spearman correlation analysis to explore the potential relationships between bacterial abundance and metabolic phenotypes. We found that Faecalibacterium, which was enriched in the participants on Day 84 in the CP group, had a negative correlation with several metabolic phenotypes (HbA1c, FBG, 2hPBG, SBP and TC). Akkermansia, which was also enriched in the participants on Day 84 in the CP group, was negatively related to a few metabolic markers (HbA1c, FBG and TC). Prevotella_9 had a positive relationship with several metabolic markers (FBG, OGTT Glucose AUC, 2hPBG and TC) (