Study Design
weight loss
In BARI-OPTIMISE, a double-blinded, randomized, placebo-controlled, parallel group trial, we recruited patients with poor weight loss and a suboptimal nutrient-stimulated GLP-1 response at least 12 months following primary RYGB or SG. The trial was undertaken at University College London Hospital (UCLH). Participants were recruited from UCLH and Homerton University Hospital, London, UK. The study protocol and statistical analysis plan are included in Poor weight loss was defined as 20% or less total body weight loss from the day of surgery. Circulating GLP-1 levels were measured in the fasted state and 30 minutes following a 500-kcal test meal. Suboptimal GLP-1 response was defined as a 2-fold or less increase in circulating active GLP-1 between 0 and 30 minutes following the meal. This cutoff was based on a previous study