INTRODUCTION
major depression, non‐skin malignancy, cancer, lung cancer, Prostate cancer, depression, prostate cancer
CANCER, MINOR, LUNG CANCER, PROSTATE CANCER, SECONDARY, PROSTATE CANCER
Prostate cancer is the most widely diagnosed non‐skin malignancy in North American men.In the general population, epidemiological studies have consistently found associations between a greater fish consumption and omega‐3 (n‐3) polyunsaturated fatty acids (PUFA) intake and a reduced risk for depression,A handful of studies have looked at relationships between n‐3 PUFA consumption/levels and psychological symptoms in patients with cancer. In lung cancer, no significant difference was found on serum levels of n‐3 PUFA between patients with severe major depression and nondepressed patients, but the group with minor depression had significantly higher DHA levels than the other two.In sum, the existing evidence, mainly cross‐sectional, has provided equivocal findings on the link between PUFA intake/levels and several symptoms in the context of cancer. More RCTs are needed to establish causality, and no study has been conducted in the context of prostate cancer. This study is a secondary analysis of an RCT assessing the effects of eicosapentaenoic acid monoacylglyceride (MAG‐EPA) supplementation on biological and quality of life outcomes in men treated with RP for prostate cancer (Gleason score ≥7 and grade group ≥2