Trial procedures and blinding
Patients underwent cardiac troponin testing at presentation and six or 12 hours after the onset of symptoms at the discretion of the attending clinician in accordance with contemporaneous national and international practice guidelines during the conduct of the trial.The standard care assay was a contemporary cardiac troponin I assay (Abbott Laboratories; Abbott Park, IL), which has a coefficient of variation of <10% at 0.04 µg/L at seven hospital sites and 0.05 µg/L at three hospital sites. During standard care, only results above these thresholds were reported. The high sensitivity assay was the ARCHITECT