5. Conclusions
weight loss, PCOS
HYPERANDROGENISM
In summary, the results of this randomised controlled trial comparing a VLCD based on full meal replacement with a conventional energy deficit approach in PCOS suggests that both approaches can be used to achieve short-term weight loss in this population. However, the study found that the VLCD resulted in greater weight loss and more pronounced improvements in body composition, hyperandrogenism, and metabolic aspects related to PCOS. While these findings are promising, these are based on a small, single-centre study, and further large multicentre RCTs are needed to evaluate the widespread use of VLCDs and moderately energy-restricted diets for managing overweight/obesity in women with PCOS.