Methods
allergic, neuropathic pain, neuropathy, hyperthyroidism, psychiatric, diabetic, hypotension, cardiovascular, kidney disease, peripheral neuropathy, diabetes
NEUROPATHY, HYPERTHYROIDISM, DRUG INTERACTION, HYPOTHYROIDISM, PERIPHERAL NEUROPATHY, DIABETES
The current research is a randomized clinical trial on two groups with a pre-intervention phase and three post-intervention assessments (after two, four, and eight weeks). The population consisted of all diabetic patients with peripheral neuropathy who sought medication in the diabetes clinic of Yasuj during the first half of 2021. The inclusion criteria were: (1) Informed consent of all participants, (2) being diagnosed with diabetes and having symptoms of peripheral neuropathy, (3) being aged between 30 and 60, (4) being able to participate in the study, (5) not suffering from chronic (cardiovascular, kidney disease, and hyperthyroidism or hypothyroidism), neurological, and severe psychiatric illnesses, (6) not being pregnant or involved in breast-feeding, (7) no simultaneous use of medicines (antipsychotics, analgesics, or tricyclic antidepressants) which can affect neuropathic pain, and (8) not having hypotension (having + 11 blood pressure). Also, our exclusion criteria were (1) being highly allergic to clonidine, (2) being diagnosed with neuropathy for causes other than diabetes, (3) experiencing worsened symptoms due to taking the medicines, and (4) having a severe drop in blood pressure or drug interaction.