Discussion
cancer, death, tumour
CANCER, TUMOUR
We provide here documentation of a clinical activity of netrin-1 titration using NP137 as monotherapy. Whereas the interest in targeting netrin-1 in the cancer field is relatively recentHowever, we have shown here that, not only does NP137 induce tumour cell death, but it also appears to impact tumour EMT. Only a few previous studies have suggested that netrin-1 may be implicated in EMT, and these showed only in vitro data