Participants
CIPN
RECRUITMENT
The study sample included 2871 participants who provided CIPN data (of the total 6088 SCOT cohort). As per the SCOT’s design, the CIPN sub-study of SCOT did not require the same number of participants as the main evaluation and the recruitment target was 1800 participants. CIPN data were collected from all recruited participants until the required number was reached. The discontinuation of data collection was endorsed by SCOT’s independent data-monitoring committee and SCOT’s steering committee, based on an interim data analysis and accounting for missing data. Further details of the methods and outcomes for the SCOT trial are reported in the study by Iveson et al. 2018.