Oral corticosteroids suppress the clinical response induced by topical IMQ application
Oral prednisolone or placebo was administered at 0.25 mg/kg per dose b.i.d. for a period of six consecutive days, and the effects on IMQ-driven clinical responses were evaluated. IMQ was applied for a maximum of 48 h under occlusion, after the skin was tape-stripped 20 times. Maximal responses were observed 48 h after IMQ application in the placebo group (Imaging and biophysical based assessments. Pre-IMQ timepoint refers to assessment prior to IMQ application, whereas 24h refers to 1x IMQ application and 48h to 2x IMQ application. 72h refers to 2x IMQ application however measured 24 hours post last IMQ application. For the following measurements prednisolone is compared to placebo. 