Edema volumetric analysis
edema
EDEMA
Digital Imaging and Communications in Medicine files for study MRIs were imported into Horos (version 3.3.6), and a blinded reviewer used non-motion degraded, axial, FLAIR sequences to segment perilesional FLAIR hyperintense signal. The Horos volume generator function was used to determine the total FLAIR signal volume for each study MRI. Volume of edema at each study MRI was normalized relative to baseline levels. Grouped comparisons were made by calculating the mean normalized edema volume with 95% confidence intervals at the timepoints outlined in the protocol every 4 weeks for 28 weeks and then every 8 weeks thereafter.