2.7. Polygenic risk scores
∑We
REGRESSION
We computed polygenic risk scores (PRSs), for the cases and controls, as the sum of the number of risk alleles carried at each locus (∑We used for the estimations of the PRSs the SNPs with the p-value of the association test using the logistic regression model < 0.05, and located within the boundaries of the genes (including the UTRs) for which the combined test was significant after a Bonferroni correction for multiple testing.