Comparison of CKD patients in the trials vs. clinical practice
As patients in RCTs need, by authority request, to fulfil all guideline requirements to investigate the effect of the new drug on top of optimized standard of care treatment, a clear difference has been expected for the comparison between RCT-patients and clinical practice. It is well known that patients in clinical trials tend to be younger and represent a higher proportion of male patients, as was observed in the present analysis [