Hippocampal metabolite ratios and associations with HADS and MoCA scores
A significant negative association was present between HADS score and NAA/Cr in the hippocampal body but not hippocampal head, with lower NAA/Cr associated with poorer psychological health (Fig. Scatter plot of rawHADS and MoCA scores versus raw NAA/Cr level in the hippocampal body and headGeneral linear model results with MoCA and HADS scores as outcomes and NAA/Cr in the hippocampal body and head, or Cho/Cr levels in the hippocampal body and head as predictorsGeneral linear models with MoCA or HADS as outcomes variable across all participants (SEG&CG). NAA/Cr or Cho/Cr from MRSI voxels in the hippocampal head and body were included as predictors in the same model corrected for sex, age, education, and right hippocampal volume. Performance on MoCA was associated with NAA/Cr in the hippocampal body but not in the head, with a lower level of NAA/Cr linked to slightly higher scores, correcting for age, sex, education, and hippocampal volume in the same model (Fig. 