Results
No side reactions were found during the study period. MB application resulted in a widespread temporary discoloration of the toenails (Fig. Both groups demonstrated a continuous and significant decline in the OSI scores throughout the first 12 weeks of the evaluated period, but a slight rebound through the following 12 weeks (Table Mean degree of improvement at 28 weeks was somewhat higher in the group treated with urea, which remained throughout the following 12 weeks. However, in the group pretreated with Fr Er:YAG laser, the mean degree of improvement decreased in the last 12 weeks evaluated (Table The percentage of nail involvement decreased significantly in both groups at 28 weeks, declining gently at 40 weeks in the group pretreated with urea, in contrast to the group pretreated with Fr Er:YAG laser, in which it was observed a clear rebound (Table Despite the different trend of the results showed for each group in the last 12 weeks evaluated, no statistically significant differences were detected between the groups for mean degree of improvement and percentage of nail affectation values at 28 and 40 weeks.Mycological cure rate was 20% and clinical cure rate was 40% (values of outstanding degree of improvement) at 28 weeks in the group pretreated with urea, increasing significantly up to 70% and 60%, respectively, at 40 weeks (Table Mean grade of satisfaction was 3.2 for urea pretreatment and 3.9 for Fr Er:YAG laser pretreatment (Table 