The self-rated quick inventory of depressive symptoms (QIDS-SR)
TSD, Depressive
TSD
The average Quick Inventory of Depressive Symptoms (QIDS-SR) total score (mean [SD]) at baseline (day -1) was 13.0 [3.98] for group A (JNJ-54175446 early start); 12.2 [4.63] for group B (placebo pre TSD and JNJ-54175446 late start) and 10.8 [3.52] for group C (placebo) (supplemental Fig. TSD decreased the average QIDS-SR10 total score with a maximal decrease observed in the morning of study day 5 (i.e., after recovery sleep). Mean values [SD] for the QIDS-SR10 total score, assessed on Day 4 and Day 5 (between 2 and 8 h postdose on both study days) decreased from 8.2 to 4.0 [−4.2] for subjects in group C, versus 9.2–6.9 [−2.3] and 10.2–5.8 [−4.4] for subjects in the JNJ-54175446 treated groups A and B, respectively. The effects of TSD were sustained until the last day of treatment (day 10) on which the mean total score (SD) was 8.7 [5.24] for group A; 7.3 [5.24] for group B and 5.9 [3.76] for group C.