Open Abdomen with Negative Pressure Peritoneal Therapy—OPEN allocation (Intervention arm)
OA
Once the patient has been allocated to an OA, the trial protocol does not mandate the interval until fascial closure although the intention is that closure will occur expeditiously once clinically determined safe by the treating surgeon. The COOL trial protocol does not mandate any length of OA therapy, although the principle of the earliest safe formal closure is expected. The time that the temporary abdominal closure dressing will be left in place, will be left to the discretion of the attending surgeon, but typical practice guidelines mandate either formal abdominal closure or dressing changes at 24–72 h if formal abdominal closure cannot be completed [