Statistical analysis
EVENTS
The software SPSS version 26.0 (IBM Corp) was used for statistical analysis. Baseline data such as demographics and clinical characteristics were balanced and comparable. All the subjects who underwent randomization were included in the primary and exploratory analyses, and data for subjects who completed or discontinued the trial without an outcome were excluded from the day of their last visit. Events that occurred after that visit were not included. We used a mixed model for repeated measurements to estimate mean differences in HbOShapiro–Wilk normality test was used to evaluate data distribution for all continuous variables. If the continuous variables obeyed normal distribution with equal variance were expressed as mean and standard deviation (SD), paired‐sample 