Randomization and blinding
blindness
BLINDNESS
The primary investigator or coinvestigators will enroll and assign the participants to the investigations. Two groups will be randomly assigned using the envelope method. D-Sorbitol and placebo will be administered in clear containers, as they are visually indistinguishable. The participants can distinguish between the two liquids based on their level of sweetness. We just informed the patients that we would ask them to evaluate the effect of the two different solutions on bitterness but did not indicate which flavor was the placebo. Even if they can distinguish between the liquids, blindness is expected to be maintained. Only the participants will be blinded.