Statistical analysis
retinal defects, VF
RETINA
Due to randomisation, demographic and baseline characteristics were similar in the two groups, and thus, no formal statistical comparisons were made.The remaining analyses compared 3-week and 6-month outcomes between the two study groups. Due to pandemic COVID restrictions, the 3-month imaging data was only available on 46/65 participants and hence was not analysed. Continuous variables normally and non-normally distributed were analysed using the unpaired For VF data, only the index eyes’ data was used. The difference between the baseline and 6-month FU was used to compare the change in mean deviation (MD) between the two groups.For the IRT data from the 8 × 8 grid data, the central 4 squares encompassing the foveal area and the peripheral squares (as variably outside the peel area) were excluded, meaning that only 32 pre-defined grid positions were included in the analysis. Inner retinal defects in these 32 grid positions were calculated and defined as follows. The baseline inner retina (IR) measurements were normalised in each square as follows:A ‘defect’ was defined as a value below 1.96 standard deviations below the mean using this normalised IR variable. Once the threshold was identified, for each patient, the number of defect areas was calculated.