Pharmacodynamics and biomarkers
tumor, tumors
TUMOR, TUMORS
Optional tumor tissue samples were collected prior to screening to measure AKR1C3 expression. OBI worked with the in vitro diagnostics company NeoGenomics Laboratories, Inc. (Aliso Viejo, CA, USA) to develop a validated immunohistochemistry (IHC) assay, which is being used to identify patients whose tumors have “high AKR1C3 expression” for inclusion in clinical trials with OBI-3424. Data from tissue microarrays or whole sections are summarized in Fig. 