Clinical Trials Registration
acute febrile illnesses, fever, infectious disease, respiratory tract infection, febrile, acute febrile illness
RESPIRATORY TRACT INFECTION, INFECTIOUS DISEASE
NCT04081051.Here, we report the main findings of the AMR Diagnostics Use Accelerator trial conducted in Ghana to evaluate the impact of a package of interventions on antibiotic prescribing and clinical outcomes for child and adult outpatients with acute febrile illness.The new paradigm of healthcare focuses on adapting treatment preferences to patient-specific characteristics to optimize health outcomes; this includes antibiotic prescriptions for acute febrile illnesses [Bacterial drug resistance is a major public health problem [Inappropriate antibiotic prescribing is one of the causes of both AMR and inadequate management of acute febrile illnesses, both of which result in increased morbidity and mortality [New point-of-care diagnostic tools and therapeutic guidelines are urgently needed. Evidence shows that the use of point-of-care diagnostic testing (POCT) may help guide antibiotic prescription as it reduces the uncertainty in diagnosing and treating an infectious disease [Our objective in this study was to compare the impact of a package of rapid diagnostic tests coupled with clinical algorithms and behavioral change communication for prescribers and caregivers on clinical outcomes and antibiotic prescriptions, with standard-of-care practices, in children and adolescents who present with acute febrile illnesses (defined as fever with no focus or respiratory tract infection that lasts for no longer than 7 days) at outpatient clinics in 2 districts in Ghana.