2.1. Study Design
BLIND
In this randomized, open-label, pilot study were enrolled persons with HIV receiving combination antiretroviral therapy (cART). The inclusion criteria included age ≥18 years and having a sedentary lifestyle, defined as less than 2 days of physical activity per week for less than 20 min per session [The protocol had a duration of 18 weeks, divided into a two-week observational period (W0–W2), aimed at collecting useful data to set up the 16-week AP protocol (W3–W18). During W0–W2, participants were monitored daily using a health band (Health Band, Philips Respironics, Pittsburgh, PA, USA) to record steps, activity time, walked distance, HR, and energy expenditure through an actigraphy and heart rate device. The health band provided health data tracking via Bluetooth technology to a mobile application installed on the participants’ smartphones, which were connected to the Philips Actigraphy Server System (PASS) website to monitor the participants’ data. At the end of W2, participants were randomized in a 1:1 ratio to either the experimental (EG) or control group (CG). In both groups, participants used the health band and mobile application; however, the EG participants could monitor exercise intensity and physical activity execution during the training session and received feedback of their training data through the app, whereas the CG participants trained with a blind configuration of the health band and mobile application and received no data feedback. The training data were also automatically downloaded from all participants to the PASS website to be monitored by the study coaches.The primary objective of the study was the comparison of the proportion of participants with an improvement from the baseline of 15% of steady-state oxygen consumption (The study protocol was approved by the Ethical Committee of San Raffaele Hospital in accordance with the Declaration of Helsinki III. This study was registered at 