Evaluation of disease remission
DISEASE, REMISSION
In the follow-up groups, a small proportion of patients achieved remission immediately after surgery – 14% in group 1 and 21% in group 2. At 6-month follow-up, remission was diagnosed in 36% of patients in group 1 and 41% in group 2. At the 12-month follow-up, 44% of group 1 and 48% of group 2 managed to achieve remission. The difference between groups is not statistically significant (p=1.02, at 12-month follow-up).After 12 months, the basal GH level normalized in 68% of patients in group 1 and 72% in group 2. By this follow-up, the GH level in the oral glucose tolerance test reached 65 and 70%, respectively. IGF-1 normalized in 56 and 61% of patients, respectively. There was no statistically significant difference in these two indicators was found between groups (p=0.546 and p=0.784, respectively). Thus, both surgical methods lead to disease remission, and the effects are generally similar.