Patients and treatments
Prostate Cancer
EXTENSIVE DISEASE, PROSTATE CANCER
Eligible patients who provided written informed consent were recruited at one center, University of Texas Health Science Center, San Antonio, United States between July of 2011 through July of 2015.During this period, three randomized phase III trials reported the clinical benefit of adding docetaxel to ADT: Chemohormonal Therapy Versus Androgen Ablation Randomized Trial for Extensive Disease in Prostate Cancer (CHAARTED); [Forty-one patients signed consent; five patients failed screening. Two of the patients who failed screening were lost to follow up, two patients did not meet inclusion criteria and one patient moved out of the region. Thirty-six patients were randomized from which 19 were allocated to empiric treatment with metformin, the remaining 17 patients were allocated to placebo. All 19 patients in the metformin arm and 17 patients in the placebo arms were included in analysis (