Physical examination
BLOOD, CREST
The physical examination included assessments of height, weight, waist and hip circumference, and blood pressure. The physical assessments were performed at baseline, 3 and 6 months after starting Obex® or placebo.Height and weight were measured, and body mass index (BMI) was calculated as weight (kg) divided by height squared (mWaist circumference (WC) was measured with the person standing, with an inelastic tape at the midpoint between the lower margin of the rib cage and the superior iliac crest, during mild expiration. Waist-to-hip ratio (WHR) was defined as the ratio of waist girth to the circumference of the hips measured at the greater trochanter. Measurements were obtained in duplicate, and their averages were used for the analysis. The waist/height ratio (WHTR) was calculated as WC (cm) divided by height (cm). The conicity index was calculated according to the formula proposed by Valdez [Blood pressure was measured three times after a 5-min rest in the sitting position using standard mercury sphygmomanometers [