References
DAY 3).Homeostatic sensations, nausea
BLIND, DELAYED GASTRIC EMPTYING
Experimental design and procedure. In a sham-controlled, parallel, randomised, blind study, a comfort meal was paired with duodenal lipid infusion to induce aversive conditioning (DAY 2) and the responses to the meal were compared before (DAY 1) and after conditioning (DAY 3).Homeostatic sensations. Concomitant duodenal lipid infusion on day 2 impaired the postprandial response and the effect was significant for abdominal discomfort and nausea (effect measured as the change in the area under the curve on day 2 minus day 1; * Hedonic sensations. Concomitant duodenal lipid infusion on day 2 impaired the postprandial response and the effect was significant for digestive well-being (effect measured as the change in the area under the curve on day 2 minus day 1; * Reward value during meal ingestion. The comfort meal was served in 3 portions; meal wanting was measured before each serving and at the end of ingestion; meal liking was measured after each serving. On day 2, concomitant duodenal lipid infusion impaired the ingestive response (effect measured as the change in the area under the curve on day 2 minus day 1 vs. sham infusion; * Digestive response to meal ingestion. On day 2, duodenal lipid infusion in the test group was associated with a sustained increase in antral cross-sectional area (delayed gastric emptying; * 