Hybrid method analysis (WOCF and MI)
atopy, atopic
ATOPY, EVENT, ATOPIC
In the primary analysis of change from baseline in WI-NRS (continuous variable) at week 12 (or 24), the hybrid method of the WOCF and MI was used. Similar to the continuous variable, the same imputation method was used in the analysis of the proportion of patients with improvement (reduction) in WI-NRS by ≥4 from baseline to week 12 (or 24), which is consistent for the intercurrent event strategy and missing data handling in the binary variables and continuous variable. That is, after the imputation of continuous WI-NRS data at week 12 (or 24) using the hybrid method of the WOCF and MI, responders were defined as patients with improvement in WI-NRS by ≥4 from baseline to week 12 (or 24) in each of the imputed datasets with about 40 imputations, and then the Cochran–Mantel–Haenszel test adjusted by documented history of atopy (atopic or non-atopic), stable use of TCS/TCI (yes or no), region and baseline antidepressant use (yes or no) was used. Statistical inference obtained from all imputed data was combined using Rubin’s rule (Extended Data Table 