INTRODUCTION
postoperative pain, fever, inflammation, constipation, pain, mucositis, tooth, respiratory depression, Tooth, nausea, vomiting
POSTOPERATIVE COMPLICATIONS, INFLAMMATION, MUCOSITIS, RESPIRATORY DEPRESSION, PATHOGENESIS
Extraction of mandibular third molars, which may involve bone removal and crown sectioning, is a common oral surgical procedure associated with moderate to severe postoperative complications (Fraga et al., Tooth extraction is usually painful; therefore, several patients are reluctant to undergo therapy (Fraga et al., Analgesics should be prescribed in the postoperative period with consideration of side effects. Opioids have been linked to respiratory depression as well as nausea, vomiting, and constipation (Bailey et al., During the 1960s, ibuprofen was developed as an inhibitor of prostaglandin synthesis to reduce symptoms of fever, pain, and inflammation (Rainsford, The absence of keratinized mucosa enhances the rapid absorption of medications, which in turn augments the efficacy of topical medications. This is even true for wounds caused by tooth extraction, which have a distinct pathogenesis from mucositis (Isola, Matarese, Ramaglia, Iorio‐Siciliano, et al., Given that topical NSAIDs may offer targeted pain relief without the systemic side effects observed with oral administration, it becomes imperative to comprehensively assess the potential benefits and risks of this administration mode following tooth extraction.In an effort to bridge the prevailing knowledge gap, this research focuses on evaluating the efficacy and safety of ibuprofen‐containing gargles administered via gargling. Specifically, the study aims to assess the impact of ibuprofen gargle on postoperative pain in patients who have undergone mandibular third molar extraction, ensuring that treatment quality is not compromised.