Exclusion criteria
bleeding, congenital immunodeficiency, HIV infection, cirrhosis, hemophilia, peptic, liver disease
BLEEDING, CONGENITAL IMMUNODEFICIENCY, HIV INFECTION, GASTROINTESTINAL BLEEDING, CIRRHOSIS, HEMOPHILIA, LIVER DISEASE

Age <18 yearsThe physician’s decision that involvement in the trial was not in the patient's best interest.Known severe liver disease (e.g., cirrhosis, alanine aminotransferase level >5× the upper limit of the normal range or aspartate aminotransferase level >5× the upper limit of the normal range)Pregnancy or breast-feedingKnown HIV infection (without control)Presence of unstable cardiovascular diseasesKnown history of gastrointestinal bleeding, uncontrolled peptic or duodenal ulcerKnown history of hemophilia or other bleeding disordersHistory of organ transplantation or congenital immunodeficiency