Conclusion
critically ill
CRITICALLY ILL
Relying on intention-to-treat analyses, the POINCARE-2 conservative strategy did not reduce mortality in critically ill patients. However, an overly optimistic estimate of the expected difference in effect, as well as a smaller than expected difference in the strategy delivered between the two groups, could bias our results toward the null, and explain their non-significance. Besides, intention-to-treat analyses might not reflect the actual exposure to the strategy. As-treated analyses might help address contamination or lack of adherence of health professionals to the strategy and could strengthen the conclusions regarding what is best for critically ill patients.