Design
The study was a randomized controlled leapfrog trial with multiple parallel arms. Allocation was on an equal ratio between those arms currently in the trial at the time of an individual participant's randomization (e.g. 1:1:1 ratio when there were three arms in the trial; 1:1 ratio when there were two arms in the trial). The trial was prospectively registered on clinicaltrials.gov (NCT04791137) and the Open Science Framework (