Supplementary Material
appendicitis, trauma
APPENDICITIS, COMPLICATIONS, ACUTE APPENDICITIS
While non-operative treatment has emerged as an alternative to surgery for the treatment of uncomplicated acute appendicitis in children, comparative patient-centred outcomes are not well documented. We investigated these in a feasibility randomised trial. Of 57 randomised participants, data were available for 26. Compared with appendicectomy, children allocated to non-operative treatment reported higher short-term quality of life scores, shorter duration of requiring analgesia, more rapid return to normal activities and shorter parental absence from work. These preliminary data suggest differences exist in recovery profile and quality of life between these treatments that are important to measure in a larger RCT. Trial registration number is ISRCTN15830435.Treatment of appendicitis in children has traditionally been by appendicectomy. Over recent years, there has been increasing interest in the use of non-operative treatment as an alternative to appendicectomyA feasibility RCT comparing appendicectomy and non-operative treatment in children with suspected uncomplicated acute appendicitis was undertaken in three UK centres over a 12-month period beginning March 2017. Full details of the methodology, key clinical findings and feasibility findings of the trial have been previously reported.Patients and families were involved in the design of the trial, development of patient and family facing materials and defining outcomes to be measured.A total of 57 participants were enrolled in the trial of whom 28 were allocated to appendicectomy and 29 to non-operative treatment. Data relating to early post-discharge recovery were available for 26 participants—15 in the appendicectomy arm and 11 in the non-operative treatment arm (Profile of post-discharge recovery in each treatment armData are percentage of participants reporting data on each day. For all outcomes, n=15 for APP arm; for NOT arm n=11 for days 0–4 and n=10 for days 5–14.APP, appendicectomy arm; NOT, non-operative treatment arm.Health-related quality of life (HRQoL) (CHU-9D) during the trial. Data are mean with SD, HRQoL is scored on a scale from 0 (dead) to1 (perfect health).While we acknowledge a relatively small sample size and incomplete data, our observation of an apparent difference in early post-discharge recovery profile between participants allocated to appendicectomy or non-operative treatment is an important finding with relevance for both clinical practice and future research. Avoidance of general anaesthesia, trauma of surgery and lack of exposure to operative/postoperative complications are viewed as potential benefits of non-operative treatment over surgery by patients and parents. Our data suggest there may be additional benefits to non-operative treatment over surgery in terms of more rapid return to baseline activity status and societal benefits with fewer days of parental work absence. Patients and parents may wish to consider these as well as more direct clinical outcomes when considering choice of treatment. Furthermore, there appear to be short-term differences in HRQoL between treatment arms, which may be clinically meaningful and will inform the design of future cost–utility analyses.Overall our data emphasise the importance of measuring a full range of outcomes including these patient-centred outcomes in future research and provide greater insights into short-term differences in outcomes between treatment arms.