2.1. Study design
cardiovascular disease, PREDIMED-Plus
CARDIOVASCULAR DISEASE
A cross-sectional analysis of baseline data of the PREDIMED-Plus trial is shown. The PREDIMED-Plus is an ongoing 6-year, controlled, parallel-group, multicenter, randomized trial conducted in 23 Spanish sites. The trial aimed to assess the effect on cardiovascular disease morbimortality of combined dietary intervention and physical activity. The study protocol can be found at 