Plans for collection, laboratory evaluation and storage of biological specimens for genetic or molecular analysis in this trial/future use {33}
SECONDARY
During the trial period, a subset of donors have been asked if they wish to join the STRIDES/NIHR BioResource – Research Tissue Bank (henceforth, ‘STRIDES BioResource’), in keeping with the trial’s secondary objective to advance understanding of the determinants of VVRs and to help develop prevention strategies for VVRs tailored to specific donor sub-populations, based on demographic, biological, psychosocial, and other characteristics. Donors who consent to participate in the STRIDES BioResource have been asked to provide a 20-ml blood sample (at the session) and to complete online questionnaires (after the session) concerning VVRs and broader health and donation questions. A full blood count has been performed from the collected blood sample using a Sysmex-XN haematology analyser (Sysmex UK Limited, Milton Keynes, UK) to generate an extended profile of blood cell indices. Full blood count results were reviewed by NHSBT staff to identify clinically significant results for further consideration. As the STRIDES BioResource is part of the NIHR BioResource, consenting donors have also joined the NIHR BioResource Research Tissue Bank (REC: 17/EE/0025) (