fMRI data acquisition
ischemia, stroke, hemorrhage, clench
STROKE, HEMORRHAGE, ISCHEMIA
T1‐ and T2‐weighted structural and task‐based functional images were acquired on a 3 T MRI scanner (Siemens) at Shanghai Key Laboratory of Magnetic Resonance. T1‐weighted images were obtained using a magnetization‐prepared rapid gradient echo sequence (TR = 1900 ms, TE = 3.42 ms, TI = 900 ms, FOV = 240 × 240 mmThe fMRI scanning included two sessions, each with the affected and unaffected hands performing passive finger flexion–extension tasks. A 6 s dummy scan was performed at the start of each session to stabilize the BOLD signal, which was then discarded in the subsequent analysis. A block design was then adopted with 5 rest blocks and 5 task blocks in each session (10 volumes/30 s for each block). During each task block, passive movements were conducted with an experimenter who was blinded to the treatment condition. The experimenter was instructed to clench the hands of the subject into a fist following a voice prompt at 1 Hz under stable movement amplitude (Figure Block design for task‐based fMRI. The patients clutched their hands passively at 1 Hz with the help of an experimenter. An air‐filled rubber bulb was placed in the patient's hand to maintain consistency in movement amplitude. A total of 10 blocks including 5 REST and 5 TASK were adopted for the tb‐based fMRI. Each block spanned for 30 s. R, REST; T, TASKDemographic and clinical information for the stroke patients0.709(0.124(0.643(0.455(0.131(1.000(0.644(0.052(Abbreviations: BG, basal ganglia; CO, centrum ovale; CON, control group; CR, corona radiate; F, female; FM‐UL‐1, Fugl‐Meyer Assessment Upper Limb subscale before intervention; FM‐UL‐2, Fugl‐Meyer Assessment Upper Limb subscale after the intervention; H, hemorrhage; I, ischemia; IC, internal capsule; L, left; M, male; MIT, motor imagery training group; R, right; Tha, thalamus.