Study design and sample size calculation
MAY
In this clinical prospective randomized, double-blind study, single-tooth extractions were conducted in two contralateral sites of the same jaw using a split-mouth design in patients taking FXa inhibitors. The double-blinded approach was performed via sealed envelopes as described below. The extraction socket of the test group on one side of the jaw was filled with PRF and the one of the control group on the other side of the jaw with a hemostatic GS (Hygitec, Aegis Lifesciences, Gujarat, India). Ethical approval was obtained from the Ethical Review Board of Landesärztekammer Rheinland-Pfalz (Prot. No. 2021–16116 of 3rd May 2022).