Patients
MDD, Depression, HAMD-17
DISORDERS
During the screening period, the diagnosis of MDD was confirmed according to the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. Screening procedures included completion of the Massachusetts General Hospital Antidepressant Treatment Response Questionnaire and the 17-item Hamilton Rating Scale for Depression (HAMD-17). Eligible patients were 18–64 years old, were diagnosed with MDD with symptoms present for ≥4 weeks and had a HAMD-17 total score ≥24 at screening and D1 (prior to dosing). The full list of eligibility criteria is available in the 