Observed Absolute Risks Within Deciles of Estimated Risk at 4.13 Years of Follow-up for the Primary Cognitive Outcome
amnestic, PD, aMCI, cognitive impairment
REGRESSION, EVENT
Calibration plots display the association between average risk estimated by elastic-net Cox proportional hazards regression model and observed risk estimated by Kaplan-Meier at 4.13 years for participants separated by decile of estimated risk. The solid blue diagonal lines show a perfect expected risk vs observed risk slope of 1. The points and whiskers present the observed absolute risk and 95% CIs across deciles of overall estimated risk. Calibration assesses how well elastic-net Cox proportional hazards regression model–estimated primary cognitive outcome event rates correspond to observed rates. A formal test of calibration was performed using the Greenwood-Nam-D'Agostino test. aMCI indicates amnestic mild cognitive impairment; PD, probable dementia.eFigure 4 in 