Participants
abnormal cardiopulmonary exercise, hypoglycemic drug, cancer, unstable angina, overweight, cardiovascular and cerebrovascular diseases, T2DM, diabetes
OBESE, CANCER, DIABETIC FOOT, UNSTABLE ANGINA, DISORDERS, HIV NEPHROPATHY, PROLIFERATIVE RETINOPATHY, DIABETES
This parallel randomized controlled trial was conducted from July 2016 to July 2017 at the Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University. The convenience sampling method was used to recruit overweight and obese T2DM patients. The patients were recruited mainly via the internet, radio and television stations and outpatient visits. The patients contacted the project leader, and the investigators evaluated their condition of the patients to determine whether they could be included in this study based on the inclusion and exclusion criteria.The inclusion criteria were (1) T2DM based on the 1999 WHO diagnosis and classification of diabetes; (2) age between 18 and 60 years; (3) body mass index (BMI) > 24 kg/mThe exclusion criteria were (1) severe heart, brain, kidney (e.g., stage IV nephropathy or creatinine > 2 mg/dl), eye (e.g., proliferative retinopathy), diabetic foot, severe cardiovascular and cerebrovascular diseases and abnormal cardiopulmonary exercise test; (2) unstable angina or co‐infection; (3) mental disorders; (4) cancer, with radiotherapy or chemotherapy in the past 6 months; (5) participation in other clinical trials; or (6) any condition requiring hypoglycemic drug discontinuation.