Deuterated water assessment
Plasma glucose was assessed from blood samples collected at baseline and on day 35 of treatment after an 8-h fast (15 min before consumption of a liquid mixed meal) and at 15, 30, 45, 60, 120, 180 and 220 min after a liquid mixed meal (Ensure Plus, Abbott Nutrition) nutritional supplement containing 86 g carbohydrates (37 g sugars), 18 g fat and 22 g protein; 400 ml; 590 kcal). For plasma analysis of gluconeogenesis, deuterated water (