Introduction
chronic vascular inflammation, psoriasis, MeTS, MetS, LCD, CPP-associated cardiovascular comorbidities, erectile dysfunction
ENDOTHELIAL DYSFUNCTION, DYSFUNCTION, PSORIASIS, VASCULAR INSUFFICIENCY, ERECTILE DYSFUNCTION, CHRONIC INFLAMMATION, INFLAMMATORY SKIN DISEASE, PLAQUE PSORIASIS, ENDOTHELIAL DYSFUNCTION
The autoimmune-mediated inflammatory skin disease in 2 to 3% of the general adult population is chronic plaque psoriasis (CPP). In men, CPP is strongly associated with erectile dysfunction [The prevalence of CPP-associated MetS ranges from 20 to 50%. Compared with non-psoriatic age-matched control subjects, the risk of having MetS is at least double in psoriatic sufferers [The mechanism links between ED, MeTS, and CPP might be contributed to the chronic systemic inflammatory nature of CPP. This chronic inflammation is a predisposing factor to the development of endothelial dysfunction in CPP. Endothelial dysfunction—chronic vascular inflammation combined with nitric oxide dysfunction and vascular insufficiency—is the same pathogenic mechanism that explains the highly prevalent ED and MeTS in CPP [Recently, published psoriatic reports confirm that patients’ correct lifestyle (proper diet with increased physical activity levels) may positively affect the clinical signs/symptoms, severity/progression, outcomes of CPP [Low-calorie diets (LCD) seem to result in an improved body mass index (BMI), CPP activity, pharmacotherapies’ efficacy, and CPP-associated cardiovascular comorbidities such as MeTS, especially in sufferers who are overweight or obese [Since there are no published studies to clarify the effect of lifestyle changes (exercise and diet intervention) on ED in psoriasis patients [