Association of Response with Mutations and Other Biomarkers
tumor
TUMOR, PATHOLOGY
Response based on physical exam, imaging, or pathology was noted in 3 of 4 treated patients with mutations in DDR genes before therapy and in 6 of 7 patients with mutations in chromatin remodeling genes. Out of 10 patients with mutations in DDR or chromatin remodeling genes before treatment, 8 achieved a tumor response based on physical exam, imaging or pathology.No significant association was found between response based on physical exam, imaging or pathology and changes in Ki67, STING, and PD-L1 (ΔKi67, ΔSTING, ΔPD-L1) or Ki67, STING, PD-L1 and γ-H2Ax values, and TMB at baseline.