Rates of pCR
RS, breast or breast plus lymph nodes
EVENTS, RECURRENCE, GROUP B
With regard to pCR, there were few events reported among patients with low or intermediate RS results in the pooled data. One patient (4.8%) in Group A was found to have pCR in the breast plus lymph nodes (4.8%), while no patients in either randomized group achieved pCR in the breast or breast plus lymph nodes. While there were different rates of pCR in the lymph nodes in the randomized groups (4.3% in Group B vs 13.6% in Group C), they did not reach statistical significance (pCR according to treatment groups (All Eligible Patients)(a) Fisher’s exact test was used for categorical variables with cell counts < 5Group A = Recurrence Score < 11, Group B = Recurrence Score 11–24 (Emory) or 11–25 (VCU) receiving NET, Group C = Recurrence Score 11–24 (Emory) or 11–25 (VCU) receiving NCT, and Group D = Recurrence Score > 24 (Emory) or > 25 (VCU)Since the one Emory patient with RS result 25 did not experience pCR, sensitivity analyses re-categorizing them to group C only impacted the denominators. Significance for differences did not shift (results not shown).