Statistical analyses
In the intention-to-treat (ITT) analysis, all participants who receive at least the first dose of prescribed medications will be included, regardless of their adherence to the medication regimen. For the per-protocol (PP) analysis, only those participants who adhere to the prescribed medication regimen without violating the regulations (where violation is defined as medication compliance less than 80%) will be included and assessed (Fig. 
Flow diagram of trial. The chi-square test or Fisher’s exact test will be used to test for associations among various categorical variables, and the independent samples t-test will be used for noncategorical variables. Statistical analyses will be performed using SPSS software (version 26.0; SPSS, Chicago, IL, USA), and 