GIR
PD
In this study, the PD concentration analysis of 12 subjects was based on the PDC analysis set. The blood glucose-lowering properties of the study drug (oral insulin) were reflected by the change of GIR after drug administration. The GIR values of the two groups were observed to be gradually increasing after oral administration of oral insulin and subcutaneous injection of Novolin R. The GIR variations indicated that the study and reference drugs were all absorbed. More details are shown by mean GIRs ( ± SD) calculated after baseline correction versus time curves in Mean GIR (mg/kg/min) calculated after baseline correction versus time curves (pharmacodynamic analysis set). T, study drug, 300 IU, p.o.; R, reference drug, 0.1 IU/Kg, i.h.