Rs9984273 associates with IFN γ and IL-6 production in patients receiving glucocorticoid treatment
ARDS
ARDS
The SNP rs9984273 locates in the 3’ untranslated region (3’-UTR) of the IFNAR2 gene (chr21:33,262,760 (GRCh38)). To investigate potential binding sites of GR in the region, we utilized position weight matrices compiled from individual genomic sites from the Transfac database (Transfac matrix table, Release 2020.3) or derived from the Encode ChIP-seq data for GR [Following our in silico evaluations, we next wanted to determine, whether rs9984273 was associated with the immune status of the patients when glucocorticoids were administered. The Phase III ARDS trial (INTEREST) was optimal to analyze this effect as it had cytokine profiling of the patients for the first 14 days. IFN γ and IL-6 were chosen as indicators of immune activation as they are also associated with poor outcome in ARDS and COVID-19 [