Treatment methods
tumor, SCCHN
SQUAMOUS CELL CARCINOMA, TUMOR, PRIMARY TUMOR
Patients in both arms receive definitive CRT with CDDP at a dose of 100 mg/m
Study scheme. SCCHN, squamous cell carcinoma of the head and neck; CDDP, cisplatin; SIB, simultaneous integrated boostRadiation planning is performed 2 weeks before the start of RT. The cervical computed tomography (CT) is performed using a thermoplastic mask for fixation. In the 2-step40 method group, another planning CT scan is performed at a dose of 30 Gy per the boost IMRT plan. RT is delivered with 4–10 MV photons using IMRT at a total dose of 70 Gy in 35 fractions over 7 weeks in both arms. The gross tumor volume (GTV) is defined as the volume of the primary tumor and the metastatic lymph nodes measuring 10 mm along the short axis. The clinical target volume (CTV) includes the GTV with a 0.5- 1- cm margin. The regional lymph nodes include the bilaterally cervical lymph nodes, and details on the prophylactic field are determined according to the primary site [