Author contributions
K.K.A, D.I and K.A.A designed the study protocol, K.K.A, D.I,K.A.A, O.V.N provided oversight for the clinical trial and acquired funds for the research, D.A, O.V.N, D.I analyzed the data, K.K.A and K.A.A wrote the main manuscript text, M.A.O , M.A.A and J.K edited the manuscript text. All authors approved the manuscript.