Primary endpoint
The VAS (100-mm) change rate for WBP from baseline to 16 weeks was − 54.0 ± 38.1% in the IA PN group, and − 42.8 ± 35.8% in the IA HMWHA group, and the IA PN group showed a higher VAS change rate than the IA HMWHA group. However, there was no statistically significant difference in the VAS change rate at 16 weeks between the two groups (Comparison of change rate of weight-bearing VAS between IA PN and IA HMWHA at week 16. Significant reduction of weight-bearing VAS was observed from the baseline in both groups. However, there were no significant difference in change rate of weight-bearing VAS between two groups (IA PN = − 54.0 ± 38.1%, IA HMWHA = − 42.8 ± 35.8%, 