Statistical analysis
As assumed, three assumptions must be satisfied when using the MR method (1): the selected IVs must be strongly associated with the exposure (2); the selected IVs should not be associated with potential confounders (3); the selected IVs could only influence the outcomes through the exposure, but not other pathways We used three different MR analysis methods (random effect inverse variance weighted method (IVW), MR Egger and weighted median method) to assess the causal effects between the two.In this study, IVW was used as the primary outcome, while the MR-Egger and weighted median method were used to improve IVW estimation, as they can provide more reliable estimates in a wider range of scenarios, albeit less efficient (wider CI). MR-Egger allows all genetic variants to be pleiotropic, but requires pleiotropy to be independent of variant exposure associations (