Patients
primary papillary thyroid carcinoma, thyroid tumors, tumor, head and neck tumors, multiple cancer, parathyroid disease, isthmus carcinoma, thyroid cancer
PRIMARY PAPILLARY THYROID CARCINOMA, THYROID TUMORS, METASTASIS, TUMOR, LYMPH NODE METASTASES, MULTIPLE CANCER, PARATHYROID DISEASE, PATHOLOGY, THYROID CANCER
This was a prospective controlled study (registration no. ChiCTR2100046912), and was approved by the Ethics Committee of Beijing Tongren Hospital, Capital Medical University. Patients with primary papillary thyroid carcinoma diagnosed at Beijing Tongren Hospital between June 2021 and April 2022 who were awaiting surgery were included. The study followed the Helsinki Declaration, revised in 2013, and all the patients provided signed informed consent.The inclusion criteria were: primary papillary thyroid carcinoma diagnosed by pathology. All patients had T1-3N0-1 lesions, and imaging did not indicate distant metastasis. All patients underwent total thyroidectomy and bilateral central lymph node dissection +/- lateral neck lymph node dissection by the same treatment team. The surgical indications in this study include multiple cancer foci, bilateral cervical lymph node metastases, lateral cervical metastasis, isthmus carcinoma, T2 or T3 lesions.The exclusion criteria were: patients under 18 years of age. Patients with other pathological types of thyroid cancer or other head and neck tumors. T4 lesion. Massive thyroid tumors which may directly invade the parathyroid gland. Preoperative imaging suggesting that the tumor exceeded the capsule and involved the surrounding structures (patients in whom the extracapsular focal invasion identified during surgery would not affect the planned surgical procedure were still included in the study). Patients with a history of thyroid surgery or radiofrequency ablation. Patients with parathyroid disease or abnormal blood calcium levels before surgery. Patients choosing non-open surgery or other intraoperative imaging methods for parathyroid glands.All patients were divided into two groups based on random number generation before surgery. In the experimental group, NIRAF imaging was used to assist in identification of the location of the parathyroid glands at different stages of surgery. In the control group, the parathyroid glands were observed and located with the naked eye.