Baseline inflammation and treatment‐related cognitive changes
inflammation
REGRESSION, INFLAMMATION
Examination of treatment‐related changes in cognitive function revealed that the effects of treatment on Executive Function and Learning were moderated by baseline hsCRP levels (Treatment group differences across levels of baseline inflammation from adjusted regression models (C‐LIFE = blue; SEPA = red). As shown, post‐treatment Executive Function performance (A) and changes in Executive Function (B) worsened in the SEPA group at higher levels of baseline CRP. In contrast, changes were relatively consistent in C‐LIFE across baseline CRP levelsExploratory analyses of putative treatment changes revealed that the moderating effects of treatment were paralleled by moderating effects of aerobic fitness improvements (