Statistical analyses
±, decline in renal function, CKD, diabetes
REGRESSION, DIABETES
Of the 935 participants, there were missing data on serum folate (Participant characteristics were presented as means ± SDs for continuous variables and proportions for categorical variables, according to the tertiles of baseline plasma Se. Differences in baseline characteristics by tertiles of plasma Se were compared using ANOVA tests or chi-square tests, accordingly.ORs and 95% CIs of the study outcomes were estimated by modeling plasma Se both as a continuous variable and as tertiles using logistic regression models, without or with adjustment of covariables. Covariables were included in the models as continuous (per 1-unit increment) or categorical, as appropriate, including age (year), sex (male compared with female), eGFR [mL/(min × 1.73 mIn addition, possible modifications of the association between plasma Se (per 10-unit increment) and a rapid decline in renal function were also assessed for the following variables: age (≥60 compared with <60 years), sex, the presence of CKD (present compared with absent), the presence of diabetes (present compared with absent), treatment group (enalapril–folic acid compared with enalapril), serum folate (≥9.0 compared with <9.0 ng/mL), serum vitamin B12 (≥280 compared with <280 pmol/L), and serum tHcy (<10, 10 to <15, and ≥15 μmol/L), by including interaction terms (plasma Se, per 10-unit increment; × factor) into the multivariate-adjusted models.A 2-tailed 