Introduction
septic, Sepsis, SIRS
DISORDER, DISEASE, SEPSIS
Sepsis is a life-threatening disorder with an in-hospital mortality rate of approximately 20%. [Both the aforementioned scoring systems rely on measurement of vital parameters at consecutive points in time on specific intervals. Although physicians can compare changes in vital parameters or scores over time, the scoring systems themselves however do not incorporate potentially relevant changes in vital parameters over time. Yet, continuous physiological parameters could provide more detailed information on a patient’s health status. The use of bedside monitors at acute care departments has been common practice for years. With the aid of bedside monitoring devices, physicians have real time insight into vital parameters such as heart rate, peripheral oxygen saturation and blood pressure. Although vital measurements are performed continuously, and repeated measurements are valuable in predicting deterioration [We hypothesize that more accurate prediction of deterioration can be achieved, as compared to current risk stratification tools (i.e. SIRS, qSOFA). In this study, up to 48-h of continuously measured electrocardiography (ECG) recordings are used to derive HRV and identify time and frequency HRV features that differentiate deteriorated patients from non-deteriorated patients (i.e. non-progressive disease, recovery). The aim of this study is to identify relevant parameters to associate with clinical deterioration in early septic patients. Those are then used to develop a model to compare to other scoring systems at the ED, such as qSOFA and Sepsis Severity Score.