Introduction
comorbidity, fatigue, neurological disorders
TTP, NEUROLOGICAL DISORDERS
Competing interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.B vitamins play a crucial role in maintaining fundamental cellular functions and various essential metabolic pathways in the body. Although they do not directly provide energy, each B vitamin acts as a cofactor in energy metabolism processes. Based on the evidence presented above, we hypothesized that a 28-day supplementation of vitamin B would enhance physical performance and reduce physical fatigue. The objective of this study was to evaluate the anti-fatigue effect of vitamin B supplementation, specifically vitamin B1, B2, B6, and B12, and its potential to improve exercise performance. We employed a randomized double-blind crossover design with a 28-day supplementation period. Sixteen male and sixteen female subjects, aged 20-30 years, were divided into two groups: the placebo group (n=16, equal gender distribution) and the Ex PLUSFatigue, defined as the inability to maintain power output and strength, is a symptom or comorbidity of neurological disorders In addition to specific efficacy properties, many foods contain essential nutrients, including vitamins and minerals, which play an important role in maintaining essential cellular functions and various essential metabolic pathways Vitamin B1 (thiamine) is rapidly absorbed by the small intestine into three phosphorylated forms: thiamine monophosphate (TMP), thiamine pyrophosphate (TPP), and thiamine triphosphate (TTP) While food intake is the main source of energy, vitamins B act as catalysts, helping to convert energy into better uses to more efficiently supply what the body needs 