Safety assessment
hepatotoxicity, Hepatotoxicity
HEPATOTOXICITY
Hepatotoxicity was defined as ALT or AST more than three times the upper limit of the institution’s normal reference ranges (ALT 0–40 U/L, AST 0–35 U/L), or TBil more than two times the upper limit of the institution’s normal reference ranges (TBIL 5.1–22 umol/L). For patients with abnormal values at baseline, hepatotoxicity was defined as ALT or AST more than three times or TBil more than two times the baseline value. The relationship between hepatotoxicity and VCZ was evaluated.