Statistical methods
Based on two previous vonoprazan clinical studies (NCT01456260 and NCT01456247) [Here, we report the interim analysis at 3 years (week 156 of the maintenance phase). This interim analysis was prespecified in the study protocol to evaluate the effect of long-term administration of vonoprazan on gastric mucosal tissue. This interim analysis was not intended to provide a basis for any decision on whether to continue or terminate the study.