Keywords:
tumor
TUMOR, RECURRENCE, RECTAL CANCER, STD
Over the past decades, improved imaging, preoperative radiotherapy (RT) or conformal radiotherapy (CRT), and total mesorectal excision (TME) surgery have resulted in improved local control rates in patients with rectal cancer.LRF can occur at different time points during rectal cancer management using TNT. In poor or nonresponders to the neoadjuvant treatment, the tumor may be irresectable or lead to an R2 resection causing an early LRF (eLRF). In patients who undergo an R0 or R1 resection, an LRF may occur during follow-up as an locoregional recurrence (LRR).The aim was to investigate the rate and describe patterns of LRFs, including LRRs, in the experimental (EXP) and the standard-care (STD) treatment groups in the RAPIDO trial. Moreover, survival after an LRF was analyzed.