Pharmacokinetic samples
Pharmacokinetic samples consisted of serial dried blood spots and venous samples. DBSs were collected 2, 6, 12, 24, 48, and 72 hours pre-dose and 5, 7, 14, 21, 28, 42, 56, 70, 84, 98, and 112 days post-dose, and two venous blood samples were collected at 12 hours and 14 days post-dose. Three to five drops of mixed capillary blood from a fingerprick were individually spotted directly on filter paper cards (Whatman 903 Protein Saver Cards, GE Healthcare, Parramatta, NSW, Australia) to allow the blood to be drawn by capillary action and distributed evenly on the DBS card. The card was air-dried at room temperature for 1.5 hours and stored at <12°C for at least 3 hours to dry, placed in an airtight foil envelope with a single desiccant sachet, and stored at −80