Introduction
DISEASE, TYPE 2 DIABETES, COMPLICATIONS
Given the natural history of type 2 diabetes and the progressive decline in beta-cell function, most patients with the disease will undergo treatment intensification with the aim of preventing or delaying long-term complications [Simplification reduces the number of insulin injections and adapts the treatment strategy to consider each person’s circumstances [We report here the scheduled 2-year extension of BEYOND trial to assess the magnitude and the durability of the metabolic benefits of simplification.