Procedures
hypotension, fever, pain
Dinutuximab beta 10 mg/mPain management with oral gabapentin, and morphine was administered according to the World Health Organization guidelines. Based on the individual patient’s pain tolerance, subsequent treatment days within a cycle as well as subsequent treatment cycles could be started with an adapted intravenous morphine dose. Prophylaxis for fever was metamizole, acetaminophen, or ibuprofen, according to institutional standards. All patients received hydration during administration of dinutuximab beta to prevent hypotension.Chemotherapy, radiotherapy, hormonal anticancer therapy, or experimental anticancer medications were not permitted during the study or the 12- and 24-week follow-up periods. The use of intravenous immunoglobulin was discouraged during dinutuximab beta treatment.