Data analysis
primary pain, pain
Data were analysed using SPSS_v27.0. As this was a feasibility study, tests for significance to compare clinical and EEG measures between study groups were not performed, but descriptive statistics were applied. Feasibility outcomes are reported based on recommendations.Clinical outcomes were analyzed based on intention-to-treat principle and as per the originally assigned groups. Last observation carried forward methodology was used to impute missing data. Mean ± SDs and Mean differences (95% CI), were calculated from baseline to each interim and primary endpoint (T3) for all clinical and experimental pain measures, and descriptively compared between groups.Percentage change to baseline was calculated for primary pain (BPI) and functional (RMDQ) measures as below (e.g., for T3):A ≥ 30% decrease was considered as meaningful clinical important difference (MCID). Proportion of participants with changes ≥ MCID were calculated and descriptively compared between groups.Similarly, EEG measures (CD and FC) were also analysed descriptively and compared between groups.