WHAT IS ALREADY KNOWN ON THIS TOPIC
Thrombosis, ischaemia-reperfusion injury, Myocardial Infarction, ST-elevation myocardial infarction, Inflammation, improves myocardial salvage, atherosclerosis
MYOCARDIAL INFARCTION, THROMBOSIS, MYOCARDIAL INFARCTION, INFLAMMATION, EVENTS, ATHEROSCLEROSIS
Inflammation plays an important role in the development of atherosclerosis, myocardial infarction and ischaemia-reperfusion injury. IL-1β inhibition reduces future cardiovascular events in patients with previous MI (Canakinumab Anti-Inflammatory Thrombosis Outcome Study), while IL-6 inhibition improves myocardial salvage index in ST-elevation myocardial infarction (STEMI) patients (ASSessing the effect of Anti-IL-6 treatment in Myocardial Infarction study), but the underlying mechanisms are uncertain.