Ethics approval and consent to participate
All procedures described in this study were performed in accordance with the principles of the Declaration of Helsinki. Written informed consent was obtained from all patients. The protocol had been approved by the Ethics Committee of the University of Leipzig (No. of the approval: 056/20-ek), the Ethics Committee of the Technische Universität Dresden (No. BO-EK-581122020), and the Ethics Committee of the Hannover Medical School (No. 9195_BO_K_2020). Protocol modifications were reported to the Ethics Committees. Participant insurance was contracted for the study realization.