Study setting and study population
anacusis, Cognitive Impairment, cognitive impairment, blindness, hypacusis, POCD, dementia, psychiatric
SECONDARY, DISEASES, DYSFUNCTION, BLINDNESS
This exploratory secondary study is part of the ‘Biomarker Development for Postoperative Cognitive Impairment in the Elderly’ framework (BioCog; ‘Strengthening the Reporting of Observational Studies in Epidemiology’ (STROBE) diagram. The flow chart shows reasons displays the inclusion process until the follow-up at 3 months. Reasons for exclusion are presented in gray boxes.Besides MRI eligibility, patients were deemed eligible, when they were aged > 65, did not show signs of dementia (Mini-Mental State Examination; MMSE > 23) and were assigned for major surgery (planned surgery time > 60 min). Any condition that might interfere with the interpretation of the individual neuropsychological test performance was a reason for exclusion, e.g., anacusis or hypacusis, blindness, psychiatric diseases, or psychotropic medication (Patient characteristics.183.9 (116.3)N = 295137.8 (88.8)N = 33The table shows characteristics of all participants, the preoperative cognitive impairment (preCI) group and the postoperative cognitive dysfunction group (POCD) group. For categorical variables percentages are given instead of mean and standard deviation (SD) in parentheses. Percentages refer to the proportion of the corresponding group. The N of patients with available data was added in grey to items with cases of missing data. (ASA score ≙ American Society of Anesthesiologists’ Physical Status Classification; IQR ≙ Interquartile Range ≙ 25th to 75th percentile).