2.1. Dataset preparation
Datasets were collected for each PPAR from the identified and reported agonists. A dataset of 43 compounds for PPARα, 39 compounds for PPARγ, and 45 compounds for PPARδ were prepared. The compound’s agonist activity was expressed as EC50 (i-e. 50% of the maximum effect of a compound is exhibited at this concentration). The datasets were categorized into two sets (active and inactive) based on EC50 values. The compounds having EC50 values ranging from 0.0001 μM to 0.35 μM were kept in the active category and all the remaining were in the inactive category. The top 15 active compounds of PPARα (