What this study adds
endophthalmitis, vitritis
SEPARATION, VITRITIS, ENDOPHTHALMITIS

Since the primary analysis at 12 months, the observation at month 18 showed a further separation of the treatment arm vs. sham over the additional 6-month period for both ACP doses.GA lesion growth, square root transformed, was reduced by 28.1% (0.168 mm, 95% CI [0.066, 0.271]) with ACP 2 mg vs. sham (least squares mean values of 0.60 and 0.43 mm, respectively), and by 30.0% (0.167 mm, 95% CI [0.062, 0.273]) with ACP 4 mg vs. sham (least squares mean values of 0.56 and 0.39 mm, respectively).Intravitreal ACP over 18 months was generally well tolerated, with no cases of endophthalmitis and only one mild episode of IOI (vitritis) that did not result in study discontinuation.MNV conversion rates were 11.9% with ACP 2 mg and 15.7% with ACP 4 mg, compared to 2.7% and 2.4% in their respective sham groups.