3.4. Liver Safety and Folate Levels at the End of the Study
LIVER, NA DEFICIENCY
Liver function tests and the determination of folate levels were performed throughout the study duration, which ranged between 4 to 6 weeks after the initiation of EGCG among the subjects stratified by treatment arm. The mean folate levels also remained within the reference range, and no subject demonstrated a deficiency in the folate level at the end of the study, with no subject being on any folic acid supplementation. Moreover, the mean mid-cycle endometrial thickness averaged between 8.6 in the EGCG-only group, and 11.1 in the EGCG + clomid group, with the changes observed from screening the endometrial thickness being non-significant in the three treatment groups.