Author contributions
RECRUITMENT
H.L., J.J., and H.Z. were the principal investigators who designed and performed the research and coordinated the study; N.X., X.H., P.Q., Q.H., Y.L., and J.Y. led and participated in the site work, including the recruitment, follow-up, and data collection; S.W., J.F., L.D., Y.X., S.Z. and B.X. supervised the study; H.Z., Q.H., Y.L., and J.Y. were responsible for laboratory analyses; H.Z. and R.D. did the statistical analysis and wrote the manuscript. X.H., H.L., and J.J. interpreted the data and revised the manuscript. All authors critically reviewed the manuscript and approved the final version.