5. Conclusions
T2DM
This study concluded that 3 mg of melatonin supplementation at night increases the glycemic variability of pre- and postprandial breakfast glycemia and post-dinner glycemia in relation to fasting glycemia. Factors related to the physiology of melatonin, such as residual daytime effects of melatonin, prospective proximal effects, damage to the prospective distal effects of exogenous melatonin and patients’ genetic characteristics, may explain the results of this work. It is possible that exogenous melatonin, in smaller doses, with less risk of residual effects in the morning, has a different action on glycemic variability. Future studies, with lower doses of this hormone and for a longer period of time, are necessary to better evaluate the role of this hormone in the glycemic variability of patients with T2DM.