Patient selection
osteoporosis, diabetes
SYSTEMIC DISEASE, OSTEOPOROSIS, DIABETES
This randomized controlled trial was conducted on patients over 16 years old who visited the Chosun University Dental Hospital from October 2019 to September 2021 for treatment of a periapical lesion. Patients with an isolated periapical lesion in the maxillary anterior region and a lesion size of less than 10 mm (mesiodistal diameter) were included. Patients with systemic diseases, such as diabetes and osteoporosis that could have affected bone metabolism and healing were excluded. Teeth with immature root apex, unrestorable crowns, grade 3 mobility, or fractured roots were also excluded. Informed consent was acquired from all participants after carefully explaining the possible risks and benefits.The participants were randomly divided into either the control or two experimental groups (PRF or CGF). Randomization was performed using opaque envelopes containing concealed assignment codes with a 1:1:1 randomization allocation ratio. One of the research associates picked up an envelope before surgery and the patients were assigned into each group.
Flowchart of participants through each stage of the trial