Conclusions
Johnson and Johnson Vision
FOUNDER
In conclusion, the app-based J-OSDI and the paper-based J-OSDI were comparable in obtaining data on subjective DED symptoms. Implementing the app-based J-OSDI as a tool for the mHealth management of DED may have implications for the early diagnosis of DED and longitudinal PRO monitoring through an unintrusive collection of DED-related data in daily life.The authors thank Ohako Inc and Medical Logue Inc for developing the DryEyeRhythm app, as well as Tina Shiang, Yusuke Yoshimura, Yoshimune Hiratsuka, Satoshi Hori, Miki Uchino, and Kazuo Tsubota for the initial development of the app. This research was supported by JST COI (grant JPMJCER02WD02; TI), JSPS KAKENHI grants (20KK0207 [TI], 20K23168 [AM-I], 21K17311 [AM-I], 21K20998 [AE], and 22K16983 [AE]), the Kondou Kinen Medical Foundation, the Medical Research Encouragement Prize 2020 (TI), the Charitable Trust Fund for Ophthalmic Research in Commemoration of Santen Pharmaceutical’s Founder 2020 (TI), the Nishikawa Medical Foundation, the Medical Research Encouragement Prize 2020 (TI), the OTC Self-Medication Promotion Foundation (TI and YO), and Takeda Science Foundation 2022 (TI). The sponsors had no role in the design or performance of the study, data collection and management, analysis and interpretation of the data, preparation, review, or approval of the manuscript, or in the decision to submit the manuscript for publication.Conflicts of Interest: TI and YO are the owners of InnoJin, which developed DryEyeRhythm. TI reports receiving grants from Johnson and Johnson Vision Care, Seed, Novartis Pharma, and Kowa outside the submitted work, as well as personal fees from Santen Pharmaceutical and InnoJin. The remaining authors declare no competing interests.Authors' Contributions: KN and TI had complete access to all data in this study and take responsibility for the integrity of the data and the accuracy of the data analysis. KN, YO, and TI developed the study concept and conducted study design. KN, YO, YA, K Fujio, TH, AM-I, K Fujimoto, AE, SH, MM, MO, HK, YM, and TI contributed to the acquisition, analysis, or interpretation of data. KN, JS, AY, and TI performed the drafting of the manuscript. KN, JS, AY, AM, HK, and TI contributed to the critical revision of the manuscript for important intellectual content. AM-I, AE, and TI obtained funding. KN, AM-I, and TI performed statistical analysis. AM, HK, and TI contributed administrative, technical, or material support. AM, HK, and TI supervised the project.Supplementary Table 1. Comparison of the reliability of the app- and paper-based versions of the J-OSDI.CONSORT-eHEALTH checklist (V 1.6.1).