Statistical analysis
BLIND
The statistician generated a random sequence, and the clinician who made the evaluation was blind to the grouping. The data were statistically analyzed using SPSS 24.0. The continuous data obeying the normal distribution were expressed as mean ± standard deviation, and non-normal data were represented as median (interquartile range). The paired sample t-test or Wilcoxon signed-rank test was used for the comparison between the two groups of paired samples, and the independent sample t-test or Mann–Whitney U test was used for the comparison between the two groups of independent samples. Categorical data were described as the number of cases (percentage), and the chi-square test was used for intergroup comparison. 