Background
hypersensitivity, TKA
HYPERSENSITIVITY, INFLAMMATORY RESPONSE
Algorithms for the diagnostic approach of painful TKA have been introduced wherein hypersensitivity against implant materials is a possible cause of unexplained symptoms [Metal implants release ions due to wear and corrosion forming metallo-organic protein complexes which can be identified as agent by the immune system [Additionally several mediators have been reported to play a role in inflammatory reaction after TKA [The underlying study was initiated to investigate the inflammatory response and patient-reported outcome measures (PROMs) in coated and standard TKA. It was hypothesized, that there would be a higher inflammatory response in standard TKA but no differences in PROMs compared to coated TKA.