Introduction
tissue disorders, tissue injury, Fracture blisters, fracture, fibrosis, burns, infection, fractures, fracture blisters, blisters, skin damage
INFILTRATION, SCAR, FIBROSIS, PATHOPHYSIOLOGY, INFECTION, COMPLICATIONS
Investigating the intricate healing process of wounds is essential to understand the multifaceted nature of the wound environment and its complexity. Preclinical models, such as those used in mice, rabbits, and pigs, can be used to simulate different types of wounds, including acute and impaired ones. To ensure reproducible results during a study, investigators must select appropriate methods for monitoring wound progression. This includes non-invasive protocols such as wound tracing, photographic documentation (including image analysis), biophysical techniques, and/or invasive protocols that require wound biopsies. Wound healing is a complex process involving multiple cell types, cytokines, mediators, and the vascular system. It is the skin's way of protecting the body from environmental damage. Recent research has allowed us to better understand how wound healing works and take effective steps toward better wound care. Studies have shown that immune cell infiltration and messaging play a significant role in scar formation and fibrosis [Orthopedic surgeons must be aware of the pathophysiology and management options of fracture blisters, as these can significantly affect the outcome for patients. These blisters, which can appear between 6 and 72 h post-injury, can delay definitive fracture treatment and increase the risk for postoperative wound complications. Therefore, it is essential to have a comprehensive understanding of fracture blisters and their management options to achieve a satisfactory result [Open fractures due to severe soft tissue disorders which may lead to devastating complications are considered an orthopedic emergency. Also, closed fractures, especially fractures due to high-energy mechanisms, are often associated with severe soft tissue injury. Researches show that a negative impact on the outcome of patients is because of soft tissue damage, especially skin damage as the first skin defense barrier. In particular,Fracture blisters, develop as a sign of significant tissue damage and appear between 6 to 72 h after injury. They can delay the treatment of definitive fractures for a considerable time and simultaneously increase the risk of postoperative wound complications [In recent years, dressings with different compositions have been introduced to protect and accelerate the healing of skin damage caused by burns, fractures, and other accidents leading to skin damage. Recently, bacterial cellulose (BC) has been used in dressings to reduce the duration of wound healing [Recent studies reported the effect of dressing containing Silver on the healing process of burn wounds, healing at the skin graft site, reducing the risk of infection and hospitalization, and its cost-effectiveness. The present study aimed to investigate the effect of Agicoat silver Nano-Crystalline Dressing dressing, produced by Emad Pharmaceutical Company, on blisters caused by bone fractures.