Metabolic pathway analysis for four outcome measure.
Top significantly enriched pathways (treatment responsive vs treatment non-responsive) in each outcome measure: (A) Responders (gray shaded bars), (B) change in (Δ) MG-ADL score (vertical stripped bars), (C) MMS (open bars), and (D) change in (Δ) QMG score (dotted pattern bars). Pathway enrichment was performed using The greatest agreement between groups in the pathway analysis is between the QMG group and Responders group. A total of seven pathways related to glycosphingolipid metabolism, Vitamin H (biotin) metabolism, fatty acid metabolism, and androgen and estrogen biosynthesis and metabolism, polyunsaturated fatty acid biosynthesis, aspartate and asparagine metabolism, and C21-steroid hormone biosynthesis are commonly altered in these two outcome groups. Interestingly, the most significant p value in the Responders group is associated with xenobiotic metabolism, which includes drug metabolism.