Histopathological finding
spongiosis, dyskeratosis, hyperkeratosis, acanthosis, TablesAnalysis, ulcer
SPONGIOSIS, INFILTRATE, DYSKERATOSIS, HYPERKERATOSIS, EVENTS, ULCER
The histopathological analysis of the 15 skin biopsies of patients with CL showed morphological alterations in both epidermis and dermis before treatment. In treated wounds with APG and glucantime, alterations of the epidermis were observed in 80% (11/15) of skin biopsies; and were mainly characterized by acanthosis in 86.7% (13/15), spongiosis in 33.3% (5/15), hyperkeratosis in 73.3% (11/15), dyskeratosis in 40.0 (6/15), exocytosis in 26.7% (4/15), and ulcer in 46.6% (7/15) of skin biopsies. The histopathological alterations in the dermis were determined mainly by a lymphohistocytic pattern of variable intensity, with diffuse or focal distribution. The inflammatory pattern was intense in 40% (6/15), moderate in 53.3% (8/15) and light in 6.7% (1/15) of cases with diffuse distribution in 40% (6/15), and focal in 60% (9/15). The inflammatory infiltrate was characterized by predominance of lymphocytes (61%), followed by inflammatory cells. After 8 weeks of treatment with APG and glucantime, the inflammatory cells infiltrate patterns in the epidermis and dermis were decreased significantly. In treated wounds with glucantime only, a decrease in the histopathological features of the epidermis and dermis were also observed. The pattern of decrease was less significant, and some events continued in patients after the therapies (TablesAnalysis of histopathological changes in epidermis before and after treatmentDermal histopathological characteristics before and after treatmentHistopathological findings observed in the CL lesions in control and intervention groups. 