Author contributions
RGM
CVP, JJvO, SP, MBL and MKL designed the study. WN, RGM, THD, NN-M, OMN, JM, JvO led the clinical trial. JM, DEE, MA and SP conducted the laboratory analysis and led the interpretation. AGB led the statistical analysis. WN, RGM, THD, AGB, JJvO, SP, MBL and MKL wrote the main manuscript text. All authors read and approved the final manuscript.