CMR sub-study
left ventricular blood and myocardial volumes
A CMR sub-study was performed with imaging acquired at baseline before treatment allocation in 76 patients, and at follow-up 12.0 ± 3.1 months later in 51 patients. All CMR imaging was performed at 1.5 Tesla (Aera, Siemens Healthcare). Cine imaging was performed using steady-state free precession sequences. Automated contouring of left ventricular blood and myocardial volumes using a clinically validated artificial intelligence analysis platform (with verification by two experts) enabled calculation of left ventricular mass, chamber volumes and ejection fraction.