Statistical analysis
The full analysis set (FAS) included all randomized patients who received ≥ 1 dose of ABL or PBO and had a baseline and ≥ 1 post-baseline scan. Statistical analysis was conducted on the HSA indices obtained from DXA of 193 evaluable patients (ABL, 128; PBO, 65) and from CT of 70 evaluable patients (ABL, 47; PBO, 23). Results for postmenopausal women and men were pooled because the number of men in each group was small. Descriptive statistics were used to calculate DXA-based or CT-based HSA indices at each evaluation time point in each treatment group and are shown as mean ± standard deviation (SD). Mean percent change, along with the 95% confidence interval (CI), in HSA indices from baseline at each evaluation time point in the treatment groups and between-group differences were calculated. The mean percent change from baseline in each parameter was compared between the ABL and PBO groups at each time point using a 