Introduction
carious lesions, carious lesion, GER, caries, WSLs, lesion arrest, chronic disease
CARIES, HYDROXYAPATITE, DENTAL CARIES, CHRONIC DISEASE
Dental caries is a multifactorial chronic disease and a major public health problem [Nanotechnology is an emerging trend in dentistry. Silver nanoparticles (AgNPs) are products with high surface area and a micro- size of atoms [Self-Assembling Peptide (P11-4) restores hydroxyapatite crystals within the subsurface carious lesion by Guided Enamel Remineralisation (GER). It has hierarchical self-assembly property and forms a fibrillar scaffold with a 3D matrix in the presence of high ionic strength and acidic pH in carious lesions [P11-4 and NSF are two novel caries preventive and remineralization agents for early caries lesions. They have limited evidence base to support their relative effects with scarce information from clinical trials comparing both agents directly. Such trials can provide answers to questions about which agent to use in situations where white spot lesions in permanent teeth are present. This study compared P11-4, NSF varnish and NaF varnish in remineralizing WSLs on the buccal surfaces of permanent teeth in young adults after one, three, six and twelve months follow-up. The null hypothesis was that there would be no significant differences in lesion arrest among the three agents.