INTRODUCTION
During the pregnancy and breastfeeding periods, there is an increased risk of HIV acquisition [While studies have demonstrated the feasibility and acceptability of PrEP in maternal and child health (MCH) clinics, implementation questions remain [The World Health Organization recommends a risk‐guided approach for HIV prevention as part of prevention‐of mother‐to‐child transmission (PMTCT) programmes [It is unclear whether a risk‐guided model would reduce HIV incidence and increase appropriate PrEP decisions than universally offering PrEP. To address this question, we conducted a cluster‐randomized trial (cRCT), the PrEP Implementation for Mothers in Antenatal Care (PrIMA) study, to compare Universal and Targeted (risk‐guided) approaches to PrEP delivery. We hypothesized that Targeted PrEP delivery would result in lower HIV incidence and more appropriate PrEP decisions.