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High-grade gliomas, herpes simplex, tumour, HGGs
VIRUS, HIGH-GRADE GLIOMA, NERVOUS SYSTEM TUMOURS, TUMOUR, ONCOLYSIS, HERPES SIMPLEX
High-grade gliomas (HGGs) are central nervous system tumours of glial origin with highly malignant morphologic and genetic featuresOncolytic viruses are a form of immunotherapy in which oncolytic-virus-induced oncolysis alters the TME, promoting proinflammatory pathways, activating resident and newly recruited immune cells through exposure of viral and possibly tumour antigensHere we report safety data for a first-in-human phase I clinical trial in 41 patients with rHGG/rGBM who were treated with CAN-3110—an oncolytic virus derived from herpes simplex virus type 1 (oncolytic HSV (oHSV); ClinicalTrials.gov: 