Finding an optimal 
In order to apply 3PND for determining an optimal dose of In Fig. We apply a dose-escalation rule based on 3PND (Algorithm 2), incorporating two options: “Discrete Dose Selection” and “Monotonic-increasing Dose Sequence.” (Details on the options are described in Discussion.) To simulate a hypothetical dataset for the dose-escalation procedure and leverage the reported data from [Number of patients and cohort size: Variables specific to accelerated designs: Variables specific to standard designs: Variables shared in accelerated and standard designs: Results of dose-finding using 3PNDNote: The target AGT activity is 5 fmol/mg protein. Continuous responses are obtained by “60 - AGT activity.” Dose assigned to the last cohort of patients is the final estimate of an optimal dose for each design: 100 Figure The result of a redesign proposed by Wang and Ivanova [Results of dose-finding using 3PND: accelerated design in (