Medication adherence
Of the 41 enrolled patients, more than 90% were perfectly compliant with prophylactic minocycline administration throughout the study period. Adherence to the topical medications was lower than that to the oral prophylaxis; nevertheless, more than 80% of the patients were compliant with the topical medications (skin moisturizer containing heparinoid and topical steroids) in 80% of the days during the study period. Sunscreen was recommended for use on outings, and perfect adherence was observed throughout >70% of the period (Figure Adherence pattern for prophylaxis medication during the 8 weeks of the study period. Adherence to prophylaxis medication was evaluated every 2 weeks for 8 weeks. The respective numbers of patients who were 100% compliant with prophylaxis at weeks 2, 4, 6, and 8 with each treatment were as follows: (A) minocycline: 38, 37, 33, and 32; (B) skin moisturizer: 37, 34, 29, and 31; (C) medium topical steroid: 35, 33, 29, and 29; (D) very strong topical steroid: 34, 31, 30, and 30; (E) sunscreen: 16, 21, 22, and 21. Eight patients discontinued dacomitinib treatments before the end of week 8.