Data collection
muscle atrophy, arthritis, erosions, ’s Syndrome, bone avascular necrosis, MSM
OSTEOPOROTIC FRACTURE, VERTEBRAL COLLAPSE, MUSCLE ATROPHY, DISEASE, SYNDROME, ARTHRITIS, DISEASE
This is a registry-based observational multicenter study. Data were collected in the AIDA Network Behçet’s Syndrome Registry by 13 international reference centers for BS. The diagnosis of BS should be made according to the International Study Group (ISG) or International Criteria for Behçet’s Disease (ICBD) or PEDiatric Behçet’s Disease (PEDBD) criteria [Demographic, clinical, clinimetric, and therapeutic data of each patient were collected retrospectively from the clinical charts and prospectively during routine follow-up visits by the treating physician. Data were collected at the time of disease onset, at the start of treatment with colchicine, conventional (c-) and biologic (b-) disease-modifying anti-rheumatic drugs (DMARDs), at 3-, 6- and 12 months and at the last assessment during treatment. Only treatment courses started when the patient had active MSM were analyzed. The information on the response of MSM to a specific drug was retrieved from the registry based on the answer to the following question: “The Investigator should specify which disease manifestation(s) persisted despite … treatment”. Further information on MSM (pattern of arthritis, affected joints, disease activity, disease-related damage, presence of autoantibodies) was collected at disease onset and at each prospective visit, while retrospective forms dedicated to past treatments included the assessment of active/inactive MSM at 0, 3, 6, 12 months and at the last visit. Disease-related damage was measured using the total Behçet’s Syndrome Overall Damage Index (BODI), specific BODI musculoskeletal items (osteoporotic fracture or vertebral collapse, muscle atrophy and bone avascular necrosis) and the presence of joint erosions at the end of follow-up [