Exit criteria
CRF
ADVERSE REACTIONS, CRF, BLIND, COMPLICATIONS
Patients will leave the trial when one of the following criteria is met:
The symptoms of patients get worse after 3 days of medication;Some comorbidities, complications or special physiological changes occur during the test;Patients with poor compliance don’t reach 80% of the prescribed amount should be used in the trial;Cases breaking the blind or opening the blind urgently in the trial;Drugs out of prescribed protocol are used in the trial;Patients who want to quit the trial or refuse to accept prescription and examination have the right to withdraw from the trial according to the provisions of the informed consent. And the reason should be understood and documented possibly.Notice: Whatever reason the cases are dropped out of the trial, the CRF should be kept and transformed into final result using the last result examined, and the efficacy and adverse reactions (ADRs) should be carried out using its full data set.