Duodenal bile (TP1)
Unchanged daprodustat, duodenal bile extract
MINOR
Figure Reconstructed HPLC‐AMS radiochromatogram and UV‐chromatogram of pooled and diluted duodenal bile extract following a single intravenous Infusion of [Unchanged daprodustat accounted for only 0.5% of biliary radioactivity, indicating extensive hepatic metabolism of the parent compound. The metabolic profile in bile was comparable to that for urine and feces. The predominant metabolites in duodenal bile were M2, M3, M4, and M5, each accounting for 11% to 20% of bile radioactivity. The additional metabolite M6 peak accounted for 6% of bile radioactivity. A number of minor radioactive peaks M7, M8, M9, M10, M13, M22, and M31, as well as unassigned peaks F and G, each accounted individually for <4% of bile radioactivity. The quantified radioactivity in bile was approximately 87% of the total in the string extract pool.