Impact of treatment on phosphorylation of substrates in the 
LYSED
Bone marrow aspirates harvested prior to treatment and again prior to drug administration on Day 8 ± 2 of treatment from the same patients were shipped overnight to a central laboratory, where marrow mononuclear cells isolated on Ficoll–Hypaque gradients were lysed under denaturing conditions that preserve protein phosphorylations. Paired whole cell lysates were subjected to SDS‐polyacrylamide gel electrophoresis and immunoblotting as described in the Supplementary Method: Data 