Limitations and Future Study Directions
DISEASE
In this study, there are several notable limitations that warrant discussion. Firstly, the small sample size represents a primary constraint, significantly impacting the ability to generalize the findings. Furthermore, a critical aspect of this article pertains to the relatively brief intervention duration, spanning just four weeks. This limited timeframe may not adequately capture the nuances of the condition, particularly given its chronic nature. Additionally, it is important to note that the assessment of outcomes occurs solely at the outset and after the four-week intervention period without any follow up assessment. Another significant limitation lies in the absence of a rehabilitation intervention within the control group. This omission poses challenges in assessing the clinical efficacy of LVR in comparison to the established gold standard. As we consider integrating these maneuvers into standard MS patient care, it is crucial to evaluate feasibility, pinpoint the optimal timing in the disease’s progression, and determine the appropriate frequency of application. It is also essential to note that while our study did not specifically delve into safety metrics, the safety and tolerability of any therapeutic intervention cannot be understated. Therefore, it is necessary to conduct additional research to explore the impacts of LVR on patients with MS.