Protein functional annotation and enrichment analysis
PROLIFERATION, ADHESION
In the KEGG pathway analysis of DEPs, the significantly enriched proteins were those associated with processes, such as complement and coagulation cascades, extracellular matrix-receptor interactions, phagocytosis, cell adhesion, and protein digestion and absorption. The top 24 KEGG pathways are shown in Fig. 
Plasma proteins that differentially expressed in before exercise and after 3 months exercise (In the enrichment analysis for DEPs using GO pathway analysis (Fig. The PPI network map showed that these proteins were involved in various biological processes such as neutrophil aggregation, regulation of membrane attack complex activation, regulation of chondrocyte proliferation, very-low-density lipoprotein particle clearance, and leukocyte aggregation and molecular functions, such as Toll-like receptor 4 binding, antioxidant activity, integrin binding, glycosaminoglycan binding, and sulfur compound binding (Fig. 
The KEGG pathway and GO analysis of significantly expressed proteins. The vertical axis represents the pathway category and the horizontal axis represents the enrichment score [− log(P-value)] of the pathway. Significantly enriched pathways (P < 0.05) are presented. The data were analyzed by DAVID bioinformatics tools. (