Patient disposition and baseline demographics
NAFLD, NASH, fibrosis
INSULIN RESISTANCE, LIVER FIBROSIS, FIBROSIS
Overall, 643 patients were screened for study inclusion, with 193 patients (30.0%) meeting the entry criteria for randomization. Of the 193 patients who were randomized to study treatment, 158 patients (81.9%) completed the study (Figure CONSORT flow diagram of participant disposition by treatment group. Baseline patient demographics and characteristics are displayed in Table Demographics and baseline characteristicsReal-time readings of liver biopsies were performed at baseline to assess eligibility for entry into the study.Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; CRN, clinical research network; CVC, cenicriviroc; ELF, enhanced liver fibrosis; FIB-4, fibrosis-4; HOMA-IR, homeostatic model assessment for insulin resistance; N, number of patients in group; n, number of patients with outcome; NAS, NAFLD activity score; TXRBased on baseline liver biopsies and NASH CRN histological scoring, F3 fibrosis was present in 64.0%, 79.2%, 78.7%, and 62.5% of patients in the TXR