Parameterization of the simulation framework for variability in fecal egg counts before and after treatment.
REGRESSION
* Implies Currently, it is recommended by WHO to determine the efficacy based on individuals that were egg-positive at baseline only; however, excluding individuals who were egg-negative at baseline from the analysis may result in a substantial overestimation of drug efficacy due to regression to the mean, particularly in low endemic settings or when true drug efficacy is low. Coffeng and colleagues showed previously that this bias could be avoided by a number of alternative survey designs [