Methods
blisters, pruritus, ONFH, MP
INFILTRATION, OSTEONECROSIS OF THE FEMORAL HEAD, BULLOUS PEMPHIGOID, DISEASE, ADVERSE EFFECTS, BULLOUS PEMPHIGOID, DISEASE
Patients from the Department of Dermatology, Peking Union Medical College Hospital (PUMCH), were recruited in the case series. All patients were diagnosed with BP using at least three of the following methods: (i) hematoxylin and eosin staining demonstrating subepidermal blisters and eosinophil infiltration; (ii) direct immunofluorescence staining showing a linear deposition of IgG/IgM or complements at the basement membrane zone (BMZ); (iii) serum detection of IgG autoantibodies against BP180 (BPAG2) via an enzyme-linked immunosorbent assay; and (iv) indirect immunofluorescence showing circulating IgG antibodies binding to the BMZ. All patients in our case series have an average follow-up duration of more than 1 year.Patients who had taken medications (such as furosemide, spironolactone, amiodarone, gliptins, anti-PD-1, and anti-PD-L1) (We evaluated the clinical response and adverse effects of dupilumab in ten Chinese BP patients with varying comorbidities and severities. An initial dose of 600 mg was administered subcutaneously (SC), followed by 300 mg SC every 2 weeks in cases 2-9, and 300 mg every week in case 10 because of a serious disease condition. Owing to the severity of the disease and a more stable financial situation, the patient in case 1 initially received three doses of 600 mg preload dose every 2 weeks, followed by 300 mg every 2 weeks. Furthermore, nine of ten (90%) patients also received immunosuppressive therapy, such as a tapering course of methylprednisolone and Demographics of BP patients treated with dupilumab.BP, bullous pemphigoid; F, female; M, male; TwHF, Tripterygium wilfordii Hook F; MP, methylprednisolone; IVIG, intravenous immunoglobulin; ONFH, osteonecrosis of the femoral head; BPDAI, The Bullous Pemphigoid Disease Area Index (total maximum score of 372); BPDAI pruritus component (total maximum score of 30).*BPDAI cutoff values of 20–57 were used to define mild, moderate, and severe BP (