Study design
We conducted a two-arm, double-blind, randomized controlled trial in five cities in China (Beijing, Baotou, Dezhou, Linzi and Yakeshi). The locations of the study provinces are shown in the author’s online repository.The trial was approved by the ethics committeee of Peking University Health Science Center (IRB00001052–30063). All the participants signed informed consent forms before randomization and knew that they could withdraw from the study at any time. All patients’ information was accessible only by the personnel participating in the study. We did not provide money to the participants, but we provided gifts (a towel, an umbrella or a cup) if the participants completed one follow-up visit. The clinical trial registration number is ChiCTR2100041942. This study has no changes from the original proposal in terms of methods or outcome measures after the trial began.