2.1. Study Design
incontinence
SECONDARY, INCONTINENCE, OVERACTIVE BLADDER, INCONTINENCE
This study focusing on OAB symptoms was part of a three-month randomized, double-blinded, placebo-controlled trial (ClinicalTrials.gov NCT05013593) investigating RCE as a treatment for postmenopausal women with bladder symptoms. The primary outcome of the trial was changes in the urinary and vaginal microbiota composition, which will be reported elsewhere. In this current article, secondary outcome measures of OAB symptoms are reported. This includes changes in OAB symptom severity and incontinence assessed by two International Consultation on Incontinence Questionnaire (ICIQ) questionnaires—Overactive Bladder (ICIQ-OAB) [The timeline of the study is illustrated in 