Subgroup analyses
ventricular heart failure
BIVENTRICULAR HEART FAILURE, ACUTE HEART FAILURE
Several subgroups were explored for the primary outcome, with tests for treatment-by-subgroup interaction. The interaction terms tested were: time to treatment assignment, or the effect of an early levosimendan administration versus a later one after beginning of VA-ECMO support (until day 2 or after day 2), time of ECMO implantation (in the operating room or in the ICU), type of acute heart failure (right or left ventricular heart failure or right and left ventricular heart failure), indication for surgery (heart transplantation versus others), and renal replacement therapy (RRT) at baseline (ongoing dialysis on the day of the nested trial). The interaction was tested with the Wald test.