Clinical visit content
A 90-min clinical initial intake visit was conducted for each participant, with subsequent visits lasting from 45–75 min. Clinical visits were usually conducted on the same day as study visits, though participants had the flexibility to schedule clinical visits on days separate from study visits. The baseline clinical visit included a thorough medical intake, including a complete review of systems, and review of medications, supplements, lifestyle, diet, and exercise; and a discussion of the foundational treatment plan that all participants received, including supplements, diet, and lifestyle counseling. The second clinical visit took place one month after baseline and consisted of a review of laboratory results, a clinical evaluation of the participant’s response to the initial treatment plan, and a discussion of the individualized portion of the treatment plan (based on laboratory results), given at the end of the visit. The remaining clinical visits (at months three and six) were similar to the second visit, with changes to the treatment plan made according to patient need and/or response to treatment. Participants were given the chance to ask questions and discuss concerns at each clinical visit.