Symptoms: Ora Calibra Ocular Discomfort and 4-Symptom Questionnaire
Using the Ora Calibra Ocular Discomfort and 4-Symptom Questionnaire, a measure of discomfort severity, PL9643 treatment demonstrated improvement over placebo in mean change from baseline at week 2 in ocular discomfort (mean treatment difference −0.4 (0.19); nominal Difference between PL9643 and placebo at weeks 2 and 12 for the population with moderate to severe DED. Ora Calibra Ocular Discomfort and 4-Symptom Questionnaire 