Introduction
angina
ACUTE CORONARY SYNDROME
Percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) are established treatments for acute coronary syndrome [We have developed a low-intensity pulsed ultrasound (LIPUS) therapy as a novel, non-invasive angiogenic therapy, which upregulates endothelial nitric oxide synthase (eNOS) and other angiogenic factors selectively in ischemic tissues [In the present study, we conducted a randomized, double-blind, placebo-controlled pilot trial in order to address the efficacy and safety of the LIPUS therapy for patients with refractory angina without indication of PCI or CABG.