Assessment of overall treatment efficacy
SE, gastric pain, alopecia
ADVERSE REACTIONS, ALOPECIA, PERIPHERAL NEUROPATHY, RECURRENT APHTHOUS STOMATITIS
Of the 106 participants, six reported adverse reactions and all were on colchicine (gastric pain, peripheral neuropathy, and alopecia). The mean USS for all the participants was 34.9 ± 7.2 (SD) before treatment and 17.5 (± 8.9) at the end of the trial (p < 0.001). The mean USS progressively and significantly decreased after 3 months, 6 months and 9 months treatment (p < 0.001). Although there was a small further reduction in the mean USS after 12 months treatment, this was not statistically significant when compared with the score at 9 months but remained significantly less than the baseline visit (p < 0.0001) (Table 
Comparison of the efficacy of three treatment modalities for recurrent aphthous stomatitis over one year
(mean ± SE)
