Introduction
critically ill, ill, fungal infections, IFI
CRITICALLY ILL, FUNGAL INFECTIONS, INVASIVE FUNGAL INFECTION
Despite medical advances, fungal infections are a significant morbidity and mortality cause. Invasive fungal infection (IFI) in critically ill patients continues to present a hurdle and significant challenge for the clinician (However, individualized dose adjustment is critical to achieving optimal serum VCZ concentration. VCZ has non-linear pharmacokinetics due to its saturable metabolism. The proportion of exposure dose increase is much more significant than the dose increase for VCZ. Therefore, VCZ serum trough concentrations (VCZ-The high interindividual pharmacokinetic variability of VCZ is mainly influenced by the liver through cytochrome CYP2C19 and, to a lesser extent, by CYP2C9 and CYP3A4 (Therefore, the study aimed to (і) Determine the guiding significance of the CYP2C19 genetic polymorphisms for the initial loading dose of VCZ in ill patients; (ii) Determine factors affecting VCZ-