Safety stopping bounds
The stopping bound component generates NCI-DLT and PRO-DLT stopping bounds at the lowest study dose level based on Agresti–Coull binomial confidence interval estimation, based on the following input parameters.The target NCI-CTACE (or PRO-CTCAE) DLT probability (i.e., 0.20 or 0.55).The maximum sample size for the study (i.e., 15).The confidence level for safety stopping rule at the lowest study dose level (i.e., 0.70).These input parameters would generate the stopping bounds reported in 