Introduction
lung cancer, cancer, gliomas
ADVERSE EVENTS, CANCER, GLIOBLASTOMA, LUNG CANCER, GLIOMAS
Repurposing of drugs to treat patients with cancer has emerged as a relevant approach.Glioblastoma (GB) is the most common and unfortunately also the most malignant of the diffuse gliomas.The amount of clinical data on disulfiram with or without copper as an anticancer therapy does not yet match the preclinical evidence. A small phase II study in patients with lung cancer indicated limited adverse events with a dose of 120 mg disulfiram daily, and the study provided indications of prolonged survival.This randomized clinical trial was designed to further investigate the effect of disulfiram for recurrent GB. The study compared disulfiram and copper in combination with alkylating chemotherapy vs alkylating chemotherapy alone.