Original study design
panic disorder, agoraphobia, Anxiety
The aim of the PARADIES cluster randomized trial (cRCT; conducted between 2012 and 2016) was to deliver a low intensity and effective therapy to people with panic disorder with or without agoraphobia in a primary care setting. This cRCT in 73 GPs’ practices included 419 patients with panic disorder with or without agoraphobia (mean age: 46.2 years [standard deviation: 14.4]; 74% female). At baseline, patients were blinded to group membership. Patients in the intervention group (IG, 36 practices, 230 patients) received case-management [Initially, patients were screened by participating GPs and their teams, using the Overall Anxiety Severity and Impairment Scale (OASIS) [The PARADIES study was approved by Ethics Committee of the Friedrich-Schiller University Jena on 17 August 2012 (no. 3484–06/12). All participating physicians and patients gave their written informed consent to participating in the study. The study was registered with Current Controlled Trials (ISRCTN64669297) and the German Clinical Trials Register (Deutsches Register Klinischer Studien, DRKS, DRKS00004386).