RIII Reflexes, SEPs, and Pain Ratings
NRS, pain
RIII reflex and SEP recordings were performed as described in detail previously [Each 2-min cycle of suprathreshold RIII reflex recording (Fig. SEP traces were visually examined and discarded if the amplitude exceeded 100 µV or artifacts were present. The remaining 10 to 12 traces were averaged for each 2-min cycle, and 4 average amplitudes were extracted using the following analysis windows: 35–50 ms after stimulation for the P45 peak, 70–100 ms for the N100, 100–150 ms for the N120, and 280–350 ms for the P260 peak, according to our previous procedure [The average pain intensity of the last 5 electrical sural nerve stimuli was rated at the end of each 2-min cycle on the NRS (0–10, 0 = no pain, 10 = strongest imaginable pain).