Participants
IRREGULAR MENSTRUAL CYCLE
We enrolled healthy Japanese women who met the following inclusion criteria: age > 20 years, a regular menstrual cycle of 25–38 days with a variation of ≤ 6 days, cyclical onset or worsening of water retention symptoms during the luteal phase, ability to understand the procedures, and provision of informed consent for study participation and intention to comply with the study requirements. The exclusion criteria were as follows: taking any continuous medications or dietary supplements, pregnancy, breastfeeding or intending to become pregnant, current or a history of acute or chronic severe conditions, and clinically relevant findings on physical examination or blood testing.