Study Flow Diagram
ONCOLOGY
RT indicates radiation therapy; RTOG, Radiation Therapy Oncology Group.RTOG 8501, which was conducted between January 1986 and April 1990 and predated ClinicalTrials.gov, was a prospective, multi-institutional randomized phase 3 trial that compared high-dose RT alone with CRT.RTOG 9405, which was conducted between June 1995 and July 1999, was a prospective, multi-institutional randomized phase 3 trial that compared standard-dose CRT with high-dose CRT.RTOG 0436, which was conducted between June 2008 and February 2013, was a prospective, multi-institutional randomized phase 3 trial that compared standard-dose CRT without cetuximab and with cetuximab.