Limitations
The main limitation in this study is that the number of participants completing the 12-month acute trial with an acceptable adherence to the intervention was lower than expected. We were therefore not able to conduct a PP analysis on the FSR in the training arm as originally planned. Further, it has recently been pointed out that there could be issues regarding recycling of tracer for the FSR calculations, which could impact the results when conducting repeated tracer infusion trials despite them being separated by several months [