Biomarkers assessment in blood samples
Serum levels of HA, COMP, and MMP-3 were evaluated at baseline and 3 months after injection. The amount of HA decreased significantly after 3 months (Fig. Serum level of biomarkers. Detection of inflammatory cytokines (IL-6 and IL-10) before and 1 week and 3 months after injection is shown in Fig. Determination of inflammatory biomarkers in blood serum. 