Conclusions
tumor
TUMOR
In this phase 1 nonrandomized controlled trial, IT GLA-SE with concurrent radiotherapy was safe, with preliminary evidence of efficacy in the injected tumor. However, further study is warranted. In patients with durable local response, there was evidence of intratumoral T-cell clonal expansion of both preexisting and novel TCRs; these unique TCRs were then detected in circulating PBMCs after treatment and had a T