Limitations
When examining the previous successful thermoregulatory results demonstrated in animal models, it becomes clear that loading the supplement regularly is a key element to elicit the desired changes (Willingham et al., Further, this study was designed to determine if the known impacts of BET supplementation would translate from lower order models (i.e., cell culture, plant, and animal models) to humans. As such, to minimize the known impacts of fluid (White et al., 