Procedures
DOWN SYNDROME, ANEUPLOIDY
Eligible participants were referred by doctors running the antenatal clinic after subjects were confirmed to have a viable singleton pregnancy on ultrasound. Consent was obtained by members of the study team and subjects were randomised to receive the intervention or control. Women were randomised to receive the intervention or standard care using computer‐generated randomisation. Randomisation allocation was placed in sealed opaque sequentially numbered envelopes. The study team member recruiting subjects was blinded to the randomisation sequence. Due to the nature of the intervention, blinding of subjects was not possible. Women randomised to the intervention were asked to watch a 16‐min educational video in a separate room. They then resumed their consult with the referring doctor to clarify any questions and to inform them of which screening option they decided on, if any. Women in the control group were counselled by the referring doctor regarding the aneuploidy screening options of FTS or NIPS and provided with information about the procedures involved for each test, their detection rates, cost, and possible results of testing. The use of a written information leaflet was available to doctors as an adjunct to providing this information. The length of the consult ranged anywhere from 5 to 15 min depending on whether the subject had any questions pertaining to pregnancy or aneuploidy screening.The intervention was a 16‐min educational video created by the study investigators, which provided information about Down syndrome, diagnostic tests and screening tests, and is available via the following link: Following the consultation with the doctor, subjects in both the intervention and control group were asked to complete a questionnaire, which assessed the primary outcome measure of informed choice. The questionnaire also assessed background demographics of patients, including age, ethnicity, educational background, parity, whether they were religious, and whether they had performed aneuploidy screening in their previous pregnancies.