Injection of MPCs
URETHRA
The injection was performed according to a standardised procedure under general anaesthesia and in full lithotomy position. Before starting the operation, the batch number from the GMP facility was double-checked with the patient’s study ID. After insertion of a vaginal ultrasound probe (BK Medical®, Endocavity 3D 8838) the anatomy was assessed, and the EUS identified. Then, a transurethral catheter (Rüsch®, SupraCath Silicone Ch10) was inserted. The implantation of the cooled final product (autologous MPCs) was performed through transurethral injections under ultrasound guidance into the horseshoe-configured anterior and anterolateral muscle tissue of the EUS, surrounding the proximal part of the urethra. At the end of the procedure, all devices were removed except for the indwelling catheter.