Statistical Analysis

Data normality was checked using the Shapiro-Wilk and Kolmogorov-Smirnov tests. The comparisons of the baseline variables between groups were analyzed using the Student t test for independent samples when parametric statistics were observed. If the data presented non-parametric distribution, the Mann-Whitney and dichotomous variables χ

The differences between the CT and control groups were analyzed by two-way repeated measures of ANOVA (group x time). When a signiﬁcant interaction was observed, a Bonferroni post hoc test was conducted. For all measured variables the estimated sphericity was veriﬁed according to Mauchly's W test and the Greenhouse–Geisser correction when necessary. The partial eta-squared was classified according to Cohen.
