Author contributions
GS designed and supervised the study; JW and YY supervised data collection and analysis, manuscript preparation; XG, JL and SEY provided clinical data, study operations support, and manuscript preparation; PHF, CR, and YC provided statistical design and data analysis; CE, WG, and PPL performed and interpreted correlative studies; CE contributed to manuscript preparation; MM, AT, NM provided data collection; MK, GS, JM, and JW consented patients to the study; and all authors approved the manuscript.