Pharmacokinetics
Pharmacokinetic (PK) analysis for trametinib and neratinib was performed on cycle 1, day 15 with blood samples for neratinib and trametinib collected at pre-dose, 1, 3, 4, 6, 8- and 24-h post-dose. Trametinib and neratinib plasma concentrations were quantified using a validated tandem LC/MS assay as described [