Keywords
stroke
EVENTS, UNCONTROLLED HYPERTENSION, MYOCARDIAL INFARCTION, STROKE
Elevated morning and nighttime blood pressures (BP) are associated with increased risk of cardiovascular events such as stroke and myocardial infarction. We compared the long-term changes in morning and nighttime BP in patients with uncontrolled hypertension (office systolic BP between 150 and <180 mmHg/diastolic BP ≥ 90 mmHg; mean ambulatory systolic BP (SBP) between 140 and <170 mmHg; 1–3 prescribed antihypertensive medications). Eighty patients were randomized to RDN or sham control. In patients taking at least 3 antihypertensive medications at 36 months (Always-on” 24 h blood pressure (BP) lowering effect of renal denervation with sufficient reduction of nighttime and morning BP that is difficult to control even by office BP-guided intense titration of multiple antihypertensive drugs.