Conclusion
critically ill
CRITICALLY ILL
A single 10,000 IU/kg dose can rapidly and safely normalize plasma 25(OH)D concentrations in critically ill children with VDD during admission to the PICU, but with significant variability in post loading dose 25(OH)D concentrations. We established that proceeding with a Phase III multicentre trial to evaluate the impact of this loading dose regimen on clinical outcomes is feasible. Importantly, using a patient oriented primary outcome determined after hospital discharge such as health-related quality of life will require thoughtful implementation of strategies to minimize loss to follow-up. Based on the results of this pilot study, we launched the Phase III trial in June 2019 (NCT03742505), and as of February 2023, have enrolled 263 patients across 9 participating Canadian PICUs.