Data availability
For COV-2069Qualified researchers can request access to study documents (including the clinical study report, study protocol with any amendments, blank case report form, and statistical analysis plan) that support the methods and findings reported in this manuscript. Individual anonymised participant data will be considered for sharing once the product and indication has been approved by major health authorities (e.g., US Food and Drug Administration, European Medicines Agency, Pharmaceuticals and Medical Devices Agency, and so on), if there is legal authority to share the data and there is not a reasonable likelihood of participant re-identification. Requests should be submitted to For COVEAs the trial is ongoing, access to participant-level data and supporting clinical documents with qualified external researchers may be available upon request and is subject to review once the trial is complete. Such requests can be made to Moderna Inc., 200 Technology Square, Cambridge, MA 02139, USA. A materials transfer and/or data access agreement with the sponsor will be required for accessing of shared data. All other relevant data are presented in the paper. The protocol is available in the Supplementary Information: Clintrials.gov. NCT04470427. Data requests should have a response within 2 weeks.