Conclusion
INFLAMMATORY DISEASE
As corticosteroid resistance is a common phenomenon across autoimmune and inflammatory diseases, these findings also have potential broad relevance to predicting treatment responses across other conditions. This discovery would be the first identification of potentially predictive biomarkers for clinical outcome in MG. An independent validation cohort, however, is needed to confirm this panel as treatment-predictive. The metabolites and lipids are involved in immunologic and regulatory pathways providing a likely mechanistic link to treatment failure. In immune cells, non-genomic interaction of GCs results in biophysical changes in the plasma membrane that are believed to impact the function of membrane associated proteins and calcium and sodium cycling, which may also contribute to rapid immunosuppressive and anti-inflammatory effects [