Methods in analysis to handle protocol non-adherence and any statistical methods to handle missing data {20c}
To address protocol non-adherence, participant education will emphasize the importance of adhering to the protocol, while clear instructions and materials will be provided. Investigators and research staff will receive training and ongoing support. For this, monitoring and supervision procedures will be implemented to detect and correct deviations. Standardization of intervention and data collection procedures across sites will be ensured. Moreover, motivational strategies will be carried out to encourage adherence while barriers to adherence will be identified and addressed.Missing data will be imputed using the random forest method.