Data analysis
fatigue
Baseline data from fatigued patients and non-fatigued patients were compared. Changes in fatigue score before and after actual high dose thiamine treatment were calculated. Data from the group of patients with ≥ 3 points decrease in fatigue were compared to the group with < 3 points decrease.Data were analyzed by nonparametric statistics, using the Mann–Whitney ranked sum test. Data are presented as the median and interquartile range (IQR). P-values < 0.05 were considered statistically significant. Data analysis was conducted in Stata (version 18.0, StataCorp, College Station, Texas).