Appendix A
ideation, anxiety disorder, psychotic disorder, anxiety, obsessive compulsive disorder, bipolar disorder, depressive, depressive symptoms, mood stabiliser, schizophrenia, bipolar I or II, DSM-5
DISORDER, IRREGULAR MENSTRUAL CYCLE
Meets the DSM-5 diagnostic criteria for generalised anxiety disorder based on structured interview MINI 6.0.Presentation with anxiety (HAM-A ≥ 18) at the time of study entryPresentation of mild depressive symptoms (MADRS ≤ 18) at the time of study entryPrimary diagnosis other than GADPresentation of moderate to severe depressive symptoms (MADRS ≥ 18) at the time of study entryPresentation of suicidal ideation (≥ 3 on MADRS suicidal thoughts domain) at the time of study entryCurrent diagnosis of a psychotic disorder (bipolar disorder I, schizophrenia) on structured interview (MINI 6.0)Current or past diagnosis of obsessive compulsive disorder or bipolar I or II disordersCurrent substance/alcohol use disorder on structured interview (MINI 6.0)Currently taking an antidepressant, mood stabiliser, antipsychotic, anticonvulsant, warfarin, or thyroxin, or regularly using a benzodiazepine or opioid-based analgesic (more than 2 days per week)Current use of St John’s wortThree or more failed trials of pharmacotherapy for the current GAD episodeRecently commenced psychotherapy (within four weeks of study entry)Known or suspected clinically unstable systemic medical disorderPregnant or breastfeeding or trying to conceiveNot using a medically approved form of contraception (including abstinence) if female and of childbearing ageUnable to participate in all scheduled visits, treatment plan, tests, and other trial procedures according to the protocolLeft-handedPacemakerInfusion pumpsAneurysm clipsMetal prosthesesMetal jointsMetal rodsMetal platesMetal staplesNon-removable body piercingsPersons who have worked as welders or may have metal splinters in their bodyFemales: taking hormone-modulating contraception including oral contraceptive pill or implantsFemales: irregular menstrual cycle in order to ascertain days 1–10 for the conducting of scans