Discussion
esophageal diseases, liver cirrhosis, GI bleeding, gastrointestinal complaints
ESOPHAGEAL DISEASES, LIVER CIRRHOSIS, GI BLEEDING, GASTROESOPHAGEAL VARICES
This is the first study that assessed the feasibility and safety of a novel UMGI capsule endoscopy. Our results confirmed that the UMGI capsule could successfully repeat the examination and had sufficient observation of UGI tract in all patients, and realized complete and consecutive UMGI examination within one capsule. This study optimized clinical application of MCE and further benefited patients who require whole UMGI tract examination, including those with definite or suspected GI bleeding, and taking antithrombotic or non-steroidal anti-inflammatory drugs with gastrointestinal complaints [Our study highlighted the role of UMGI capsule in duodenal visualization. The major duodenal papilla presented a good surrogate maker of lesions in proximal small bowel for capsule examination, its identification was still unsatisfactory although improvement of technical parameters might promote the visualization [UMGI capsule also presented a satisfactory visualization in esophagus and stomach with controllable movement and real-time viewing, merging the advantages of string capsule and MCE. The detection rate of Z-line was 100% with a complete circumferential viewing of 66.7%, similar to that of string capsule [This study confirmed the diagnostic ability of UMGI capsule in esophageal diseases with a high consistency with EGD, showing a promising utility in detecting gastroesophageal varices in patients with liver cirrhosis [The detachable string helped effective control of the capsule, contributed to a successful consecutive inspection of the UMGI tract, and avoided the discomfort caused by pulling the capsule out [There are limitations in this trial. First, excellent diagnostic ability of UMGI capsule endoscopy with a small sample size in the pilot study merits validation in large-scale trials. Second, the longer operation time for the UGI tract under UMGI capsule endoscopy than that of EGD, especially during pyloric transit of the capsule, promotes further innovations.