Methods
We reassessed the data of Study PRGF in accordance with the RIAT recommendations. To this purpose and apart from the involved published article, we used as principal sources the following documents: (1) full original protocol, (2) ethics committee approval resolution, (3) final study report (summary version). All of them were accessed on request from the contact author of the original publication. Other related documents (Statistical Plan Analysis, study database, set of documents reviewed by the Ethics Committee and alleged final report dated November 2011) were also requested from the study authors with no response from their side.According to RIAT recommended procedures [