Effects of Kisspeptin (KP) on Sexual Brain Activity and Behavior During the Short Sexual Videos Task
baseline sexual desire distress
CORTEX
A, Whole-brain analysis showing increased activity in the left anterior cingulate and left middle frontal gyrus and decreased activity in the bilateral parahippocampus by KP administration in response to short sexual videos. Red and yellow areas show relative activation to sexual vs exercise videos (control) during KP administration compared with placebo. Blue and green areas show relative deactivation to sexual vs exercise videos during KP administration compared with placebo. Clusters are corrected for multiple comparisons (Correlating brain activity in the anatomical ROIs with behavioral measures revealed that participants with higher baseline sexual desire distress scores showed greater kisspeptin-enhanced brain activity in the posterior cingulate cortex (PCC) on viewing short sexual videos (using Sexual Concerns Inventory–Male desire distress score, 