Acute autonomic effects.
ADVERSE EFFECT
The high 500 mg mescaline dose, LSD, and psilocybin similarly increased systolic blood pressure, heart rate, body temperature, and the rate pressure product. LSD showed a significantly lower maximal diastolic blood pressure response compared with psilocybin. Conversely, LSD showed a trend toward an increase in heart rate compared with psilocybin. The data are expressed as the mean ± SEM of maximum responses in 32 participants for LSD and psilocybin and in 16 participants for each mescaline dose. The corresponding statistics are shown in Supplementary Table SMescaline (at both doses), LSD, and psilocybin similarly increased pupil size compared with placebo (Supplementary Fig. SAll drug conditions generated a higher total acute (0–12 h) adverse effect score on the List of Complaints compared with placebo (Supplementary Table S