Associations between variables of interest and PROs
bone marrow disorders, hemolysis, MDS
MYELODYSPLASTIC SYNDROME, HEMOLYSIS, BONE MARROW DISORDER, APLASTIC ANEMIA
Variables of interest included demographic characteristics (age, sex, and body mass index), baseline and ΔBL LDH levels, baseline and ΔBL Hb levels, concomitant bone marrow disorders (aplastic anemia [AA] and myelodysplastic syndrome [MDS]), transfusion, and hematological parameters (platelet and neutrophil counts, and ratio of reticulocytes to erythrocytes [%]). Baseline LDH level was defined as the average of all available assessments before the first infusion of the study drug. For all other parameters, baseline was defined as the last available assessment before the first study drug infusion. The main laboratory variables of interest in the current analyses were Hb and LDH levels (indicators of the rate of hemolysis). Associations between mean ΔBL PRO score and laboratory variables were assessed up to 26 weeks (day 183), including absolute mean LDH level, absolute mean Hb level, mean LDH response at day 183, mean ΔBL Hb level, and mean ΔBL LDH level at day 183.