Statistical analysis
Continuous variables are shown as the means and 95% Confidence interval (95% CI) and were analysed by two-tailed unpaired t tests or one-way ANOVA followed by Bonferroni-corrected pairwise tests. The enumeration data were represented by the numbers of cases (N). Incidences were compared between groups using the chi-square test or Fisher’s exact probability method. Correlation analysis of continuous variables was described by a scatter diagram. Pearson correlation analysis was used for the two groups of continuous variables consistent with a normal distribution, and Spearman correlation analysis was used for the two groups of variables with a nonnormal distribution. All statistical analyses were 2-tailed, and P < 0.05 indicated significant differences. The above statistical methods were also applied to subgroup analysis. Statistical analysis was performed using the SPSS 23.0 software package (IBM Corp, Armonk, NY). The images were produced using the Graphpad prism 8.4.2 software (GraphPad Software,USA).Several articles 