Randomization and masking
Allocation of patients to each treatment group (1:1) was administered after confirmation of the study’s enrollment by a covariate-adaptive randomization method (Pocock and Simon’s minimization method), including the following as considered factors: (1) age (≥ 75 or < 75 years), (2) E/e′ (E/e′ ≥ 15 or < 15), (3) eGFR (≥ 30 or < 30 mL/min/1.73 m