Introduction
death, heterogeneous tumors, cancer, NENs, Tumors
NEUROENDOCRINE NEOPLASM, CANCER, TUMORS
Neuroendocrine neoplasms (NENs) generally refer to all heterogeneous tumors originating from peptidergic neurons and neuroendocrine cells, which can occur in many organs and tissues of the body. The 2019 World Health Organization (WHO) classification of Tumors of the digestive system updated the digestive system NENs classification (CRNENs are more common at stage I, which can often be treated by endoscopy with a good prognosis (As there are few CRNENs-specific reports, this study examined the incidence trend for all stage CRNEN patients and identified independent prognostic factors for stage II-IV patients diagnosed from Surveillance, Epidemiology, and End Results (SEER) cancer registry. Following that, we aimed to create prognostic nomograms to provide patients and clinicians with valuable prognostic information about stage II-IV CRNENs and risk factors increasing CRNENs-related death.