Methods
obesity, cataract, non-obese, glaucoma
OBESITY, OBESE, DIABETES MELLITUS, CATARACT, GLAUCOMA, RETINAL DISEASE, HYPERTENSION
This prospective study was undergone in accordance with the principles of the Helsinki Declaration and with the approval of the Ethics Committee of Mugla University Medical School of Medicine (Registration Number: E-72855364-050.01.04-238071). Patients diagnosed with obesity and healthy controls were included in the study, which lasted from October 2020 to March 2021. All the participants signed an informed consent for the study.184 eyes of 92 adult volunteer participants were separated into 3 groups. 68 eyes were in the group of normal weighted, with a body mass index between 18.5 and 24.5 kg/ m2, 60 eyes were in the group of overweighted, with a body mass index between 25 and 29.9 kg/ m2, 56 eyes were in the obese group, with a body mass index ≥ 30 kg/ m2. Healthy non-obese adult participants, who applied to the ophthalmology clinic for a routine examination, were added to the control group.Patients diagnosed with hypertension, diabetes mellitus, cataract, glaucoma or any retinal disease, with a history of ocular surgery or low cooperation for OCTA measurement, were not included in the study, and afterwards were excluded from this study. All the subjects underwent a detailed physical examination and medical history of all the participants was established. Also, to calculate the BMI, arterial blood pressure, weight, and height measurements were taken. Moreover, to calculate the BMI, the weight in kilograms was divided by the height in squared meters (kg/ m2). All the participants were applied visual acuity and ocular motility testing. They underwent slit lamp examination for anterior segment details. Also, mydriatic fundus examination was executed. Optovue (Optovue, Inc; Fremont, CA) device was used for OCT-A. 6.00 x 6.00 mm macular region centered on the fovea was the target for measurements. The parafoveal regions of the Data collected form the participants were analyzed by SPSS version 21.0.0.0 software (IBM Corp Armonk, NY, 2012). Quantitative components were tested by the Kolmogorov-Smirnov test for the normality hypothesis. Comparisons between groups were done with independent-samples t test, Kruskall Wallis test. Pearson’s correlation analyses were performed to detect the relationships between the nonperfusion area and the OCTA parameters. It was agreed that a p value lower than 0.05 was statistically significant.