STUDY RESULTS
TRD, delusions, depressive disorder, Hallucinations, MDD, Depression
ADVERSE EVENTS, EVENTS, ADVERSE EVENT
A total of 764 patients with TRD were included in the post hoc analyses (Demographics and Clinical CharacteristicsAbbreviations: MADRS, Montgomery and Åsberg Depression Rating Scale; MDD, major depressive disorder; XR, extended release.On day 1, investigators reported an adverse event of dissociation for 14.3% (109/764) of the patients. Most of the dissociation events were characterized by the investigator as mild (n = 78), some were characterized as moderate (n = 26), and few (n = 5) were characterized as severe. Severe adverse events of dissociation were more often reported for female patients and patients who were younger, on average, than those for whom mild-to-moderate dissociation events were reported, though this pattern cannot be generalized due to the small number of patients in this subgroup. Dissociative symptoms generally resolved by 1.5 hours after esketamine dosing.Hallucinations, in contrast, were less frequent and delusions were not reported as adverse events for any patient. Hallucinations were reported in <1% of the sample (5/764). Using BPRS+ score ranges as criteria (