Discussion
atopy, allergic, milk allergy, EHF
ATOPY, MILK ALLERGY
As expected, daily intakes of glutamic acid from infant formula were significantly higher in infants randomized to EHF than CMF. However, when we accounted for other sources of nutrition and used measured rather than estimated intakes, every infant, regardless of the type of formula, exceeded the ADI for glutamic acid–glutamates (30 mg/kg bw/day) recommended by EFSA for all age groups [Infants have been fed EHF since 1942, when the first infant formula for the nutritional management of cow milk allergy was launched, and these formulas have been evaluated for their suitability and safety in numerous preclinical and clinical studies. Most notably, the randomized controlled German Infant Nutrition Intervention study on infants who were at high risk for atopy revealed long-term benefits in preventing allergic outcomes 20 years after their last exposure to extensive protein hydrolysate formulas [The 2017 EFSA ADI was not based on actual intake data of the primary energy sources during infancy or on the established safety of these important sources of nutrition [