Empirical cumulative distribution function (eCDF) curves
Empirical cumulative distribution function (eCDF) curves were plotted to visually represent the percentages of patients with changes in NIS or NIS-LL total score below each observed change score from baseline to week 65. Treatment differences in the percentage of patients at each threshold of change were explored by plotting separate curves for treatment and placebo groups and examining the distance between the curves on the y-axis at each point of the x-axis.