RESULTS
obesity, muscle mass, diarrhoea, anxiety, Sarcopenia, depression, weight loss
OBESITY, RECRUITMENT, INSULIN RESISTANCE, SARCOPENIA, COMPLICATIONS
The average age of our population was 48.73 ± 7.7 years with extremes ranging from 33 to 63 years. Half of the population (51%) was over 50 years old. The majority of participants were female 93.3% (Past medical history, complications of obesity and lab test resultsBlood pressure values are comparable in the three groups.Our three groups were matched for BMI. There was no statistically significant difference for anthropometric measurements (weight, height, IMC, fat mass, muscle mass and waist circumference) between the three groups. In addition, the majority of patients in all three groups had normal muscle strength. Sarcopenia at T0 was noted in 20% in the diet‐only group, 6.7% in the prebiotic group and 13.3% in the probiotic group.In each group, 93.3% of patients were sedentary.At recruitment, we performed a frequency questionnaire consumption of foods rich in prebiotics and probiotics such as coffee, tea, garlic, onion, fermented foods, cacao, yoghurts and fruits. There were no differences between groups.No patient reported alcohol consumption and none had a regular consumption of carob.Most of the patients of the three groups had a high level of anxiety, depression and stress but without statistically significant difference.The result of the intervention after 1 month are in Table Results of the intervention on different parameters for the three groupsBold value indicates statistically significant The results of anthropometric measurements after the intervention in the three groups showed a statistically significant decrease in weight, BMI and WC, but muscle strength has increase only with pre and probiotics.The population has significantly decreased energy and macronutrient (protein, carbohydrate and lipid) intake, with a significant decrease in sugar and sodium intake.A significant increase in fibre intake was noted in the diet and prebiotic group but not in the probiotic group. The quality of sleep was not improved by the diet only and probiotics did not enhance anxiety.Taking probiotics was associated with the occurrence of diarrhoea in 20% of cases (Then we compared the diet alone versus prebiotics group for all the parameters listed in Table Comparison of biological assessments according to the interventionBold value indicates statistically significant 
Our conclusion is that the different therapeutic means are equal for the dietary survey, the different scores (stress, sleep, anxiety and depression).The influence of the three means on weight loss is equivalent even if it is the diet alone group which reduced the weight more except for the lean mass which was clearly increased by probiotics compared to diet (Prebiotics and probiotics were better than diet for the reduction of fasting glycemia and insulin resistance but probiotics did not lower uric acid as much as others.