Image acquisition
The following MRI protocol was employed pre-FA, post-FA, pre-DE and post-DE for each participant. All images were acquired at BC Children’s Hospital on a 3 Tesla GE Discovery MR750 MRI scanner. A whole-brain anatomical MRI scan was acquired with a T1-weighted FSPGR 3D sequence, with the following parameters: a repetition time (TR) of 8.148 ms, an echo time of 3.172 ms, voxel size of 1 × 1 × 1 mm, and a flip angle of 8°. A functional MRI (fMRI) scan was obtained during resting state (with eyes open or closed). The resting state fMRI scan was 6 min in duration and obtained with a T2*-weighted echo-planar imaging sequence with the following parameters: a repetition time of 2000 ms, an echo time of 19 ms, 180 volumes, 39 slices, and a voxel size of 3 × 3 × 3 mm. Additional task-based scans were obtained following resting state scans, but were ancillary to the hypotheses being tested here.