Correlation of sputum NSPs
The correlation of sputum NSP activities was determined for all patients combined, irrespective of treatment arms at baseline and for all timepoints. The correlations of sputum NSP activities were further analyzed according to treatment group: placebo, 10 mg brensocatib, or 25 mg brensocatib at baseline and for each timepoint: week 2, week 4, week 12, week 24 and week 28.