BMI as a prognostic factor
obese, overweight, Overweight
OBESE, RECURRENCE, EVENT, SECONDARY, EVENTS
After a median follow-up period of 13.1 years (interquartile range [IQR]: 12.5-13.9) beyond randomization, 706 patients had developed a DFS event and 484 patients had died. Details about endpoint events per BMI class are presented in Endpoint events in the total study population according to body mass index class (No. [%])Patients may have had multiple disease-free survival events at the same moment.In some patients multiple locations of recurrence were reported.The 13-year DFS rates were 66.2% (95% confidence interval [CI] = 62.4% to 69.7%) in normal weight, 59.5% (95% CI = 55.7% to 63.1%) in overweight, and 52.4% (95% CI = 47.2% to 57.4%) in obese patients (Disease-free survival (A), overall survival (B), breast-cancer-specific mortality (C), and other-cause mortality (D), according to body mass index class at randomization. BCSM = breast cancer-specific mortality; DFS = disease-free survival; OCM = other-cause mortality; OS = overall survival.Multivariable analyses of primary and secondary outcomes according to body mass index class at randomization, overall and stratified by age at randomizationThe full multivariable models of the total study population are displayed in In the analyses of breast cancer-specific mortality and other-cause mortality, we reported sHR instead of HR. The 13-year OS rates were 77.6% (95% CI = 74.1% to 80.6%) in normal weight, 71.5% (95% CI = 68.0% to 74.7%) in overweight, and 67.7% (95% CI = 62.5% to 72.2%) in obese patients (Overweight and obese patients also experienced numerically higher BCSM rates when compared with normal weight patients (Furthermore, overweight and obese patients had numerically higher OCM rates when compared with normal weight patients (Age showed to be a statistically significant effect modifier of the association between BMI and DFS (