Data availability
The raw clinical data are protected and are not available due to data privacy laws. The de-identified datasets supporting the findings of this study are available for academic purposes on request from the corresponding author, Min Yan (ym200678@126.com) for 5 years, with the approval of the Institutional Ethical Committees. The trial protocol is available as Supplementary Note in the Supplementary Information. Source data are provided in this paper. The remaining data are available within the Article and Supplementary Information.