Cost assessment
subfertility, miscarriages
MISCARRIAGE, OVARIAN HYPERSTIMULATION, MISCARRIAGES, DILATION
The direct medical costs primarily included examination costs before patients underwent the subfertility treatment and IVF-related costs during the entire cycle. Based on expert research and analysis of medical costs in hospital information systems, the direct medical costs of IVF were divided into examination costs including laboratory costs and ultrasound procedures costs, drugs costs, and IVF procedures costs. The drug costs were assumed to include the costs of controlled ovarian hyperstimulation, endometrial preparation, and luteal-phase support. The costs of IVF procedures were estimated to cover the costs of ovum pickup, IVF laboratory procedure, cryo-preserved embryo transfer, and thawing procedure. Calculation of the costs incurred by PGT‑A included the cost of performing genetic analysis of three blastocysts (eTable We also collected direct medical costs associated with patients’ miscarriages and live births to estimate costs. The costs of Miscarriage were assumed to include dilation and curettage with anesthesia. The costs of prenatal checkups and cesarean sections belonged to the cost of live birth. In this study, only direct medical costs were used in the assumption analysis, as indirect costs were highly variable and difficult to calculate. All incorporated costs (in CNY) are shown in Table 