Blinding
STERILE
Participants, study physicians and nurses handling administrations of the study drugs, as well as those individuals doing the analyses, were blinded to interventions. Only the pharmacy and study personnel preparing the study drugs were unblinded to interventions.The placebo for lefitolimod, 3BNC117 and 10-1074 was sterile physiological saline. Lefitolimod or placebo for lefitolimod was provided to the study physicians and nurses handling the injections as 4× 2-ml syringes. Placebo for 3BNC117 and 10-1074 or the bNAbs was administered by the study physicians and nurses handling the infusions as 250-ml piggy bags. Labeling contained only information of the study visit and an expiration date and time irrespective of either placebo or study drug.