Author contributions
RECRUITMENT
L.L. conceived the study. F.X. wrote the protocol with input from S.L. and L.L. L.L., W.Y., and S.L. were responsible for patient treatment and patient care with help from Q.X., X.Z., M.H., K.H., X.D., Jian W., and J.L. L.L., W.Y., Z.L., C.C., and M.W. were responsible for patient recruitment. S.L., W.Y., and F.X. were responsible for coordinating trial procedures and collecting data and samples. S.L., W.Y., and L.L. were clinical investigators. W.Y., Z.L., M.W., and C.C. were responsible for surgery. S.L. analyzed and interpreted clinical data with support from L.L. and L.S. W.L. and D.Y. helped with clinical imaging. D.S. and P.G. helped with pathological evaluation. S.L. and L.S. performed bioinformatic analysis and statistical analyses with help of H.L., W.Z., Jiaqian W., and Z.Z. S.L. wrote the manuscript with input from L.L. All authors reviewed the manuscript, interpreted data, and approved the final version.