Strengths and limitations
MS-related fatigue, fatigue
This is the first study testing the effectiveness of a booster programme in improving the long-term effects after CBT for MS-related fatigue. There are several limitations to take into consideration. Only participants who adhered to the initial treatment were included in the booster trial, which may have biased the long-term effects of CBT for fatigue in a positive way. Participants non-adherent to the treatment and excluded from present RCT showed higher fatigue levels at T20, which remained high at long-term follow-up. However, the course of fatigue severity of this group of participants shows no larger fatigue relapse compared with the participants who were randomized in the present RCT (