Hippocampal metabolite ratios, intervention groups, VO
The observed mean, SD, 95% CI, and Cohen’s Mean, standard deviation (SD), and 95% confidence interval for the raw observations of NAA/Cr and Cho/Cr ratios in the hippocampal body and head in the control group (CG) and supervised exercise group (SEG)CGThe general linear model revealed a significant effect of group on NAA/Cr ratio in the hippocampal body with lower levels in SEG compared to CG after controlling for age, sex, education, and hippocampal body volume. No significant group effect was uncovered for Cho/Cr in hippocampal body or for NAA/Cr or Cho/Cr in the hippocampal head (Table Effect of intervention group on and associations of exercise measures with NAA/Cr and Cho/Cr levels in the hippocampal body and head as outcome variables#Group effect, control group > supervised exercise group, decreasing VOThere were no associations between change in VOAcross all participants (SEG&CG), weekly exercise duration was not associated with NAA/Cr or Cho/Cr in neither the hippocampal head nor body, correcting for age, sex, education, and hippocampal head or body volume. Higher exercise intensity at 3 years was associated with lower Cho/Cr level in the hippocampal body correcting for age, sex, education, and hippocampal body volume. No other associations were present for exercise intensity (Table 