Introduction
IRON DEPOSITION
Iron is an essential mineral for normal brain development and function, as it is involved in oxygen transportation, myelin production, and neurotransmitter synthesis and metabolism [It has been well known that some anatomical regions, such as the globus pallidus and substantial nigra, are more prone to iron accumulation than others [Quantitative susceptibility mapping (QSM) is recognized as a unique method with which to quantify brain iron deposition, especially in the deep gray-matter nuclei [In the present study, we hypothesized that rapid magnetic susceptibility progression in the basal ganglia would be associated with activated BBB function during the first few years of life. This study aimed to establish a relationship between brain iron dynamics and BBB function during childhood.