OSM Diversity
SEPARATION
When examining OSM diversity, several measures have been reported in the literature.Similar Chao-1 estimates and Shannon diversities between the CMC and PEG study arms and time points (Overall, it appears that the high microbial diversity associated with DES may be resilient to topical elution or short-term interventions. Based on these two trials, it is possible that long-term AT use or saline elution exceeding one month may change alpha diversity, but there is no evidence that it may convert a DES-associated OSM into a healthy control-associated OSM by reducing alpha diversity. Some interventions such as topical prostaglandin therapy may increase alpha diversity,There were no significant differences in UniFrac distances between study arms (Among the variables examined in our study, gender explained the separation in microbiome beta diversity among samples (