Study design and 
MPNs
SIMPLIFY‐1 (NCT01969838) and SIMPLIFY‐2 (NCT02101268) study designs have been previously described.The modified MPN‐SAF version 2 is an eight‐item patient‐reported questionnaire developed to assess symptom burden in patients with MPNs. All items were assessed by patients as the “worst incidence” in the prior 24 h using a 