Conclusions
CRC
The findings of this cross-sectional analysis of the recruited and eligible population for the CONFIRM study provide important insight into both groups. The CONFIRM study recruited its cohort of 50 126 adults with an average risk for CRC to compare the effectiveness of colonoscopy vs annual FIT screening for the reduction of CRC mortality. The recruited population better approximates the diversity of the US population in terms of race and ethnicity than prior large screening studies, and this is the only US study to our knowledge currently comparing these common CRC screening tests. Separately, we were able to evaluate reasons why individuals chose not to participate, which helps to elucidate current trends in preferences for noninvasive CRC screening. Specifically, our study suggests some increase in the preference for noninvasive FIT over time, especially in certain regions of the country. Further work to better understand contemporary changes in preference for CRC screening in the US is warranted.