Safety and tolerability
Treatment-emergent adverse
ADVERSE EVENT
AEs were typically mild and resolved rapidly without medical intervention (Treatment-emergent adverse events by group and stage
Abbreviations: AE, adverse event; MedDRA, Medical Dictionary for Regulatory Activities; TOMAC, tonic motor activation.Blinding was assessed at the end of stage 1. For subjects assigned to active TOMAC, 35 (54%) guessed treatment, 9 (14%) guessed sham, and 21 (32%) responded “don’t know.” For subjects assigned to sham, 10 (16%) guessed treatment, 40 (64%) guessed sham, and 13 (21%) responded “don’t know.” Guesses of treatment or sham (