Background
thalassemia, bone pain, fractures, osteoporosis
THALASSEMIA, OSTEOPOROSIS, COMPLICATIONS
Edited by: Rimesh Pal, Post Graduate Institute of Medical Education and Research (PGIMER), IndiaReviewed by: Pinaki Dutta, Post Graduate Institute of Medical Education and Research (PGIMER), India; Antonino Catalano, University of Messina, Italy†ORCID: Adisak Tantiworawit, With adequate blood transfusion and iron chelation, thalassemia patients have a longer life expectancy and experience long-term metabolic complications, including osteoporosis, fractures, and bone pain. Alendronate, an oral bisphosphonate, is currently used to treat various types of osteoporosis. However, the efficacy for the treatment of thalassemia-associated osteoporosis remains unclear.