Background
respiratory complications, PTE, asthma
LUNG, INFLAMMATION, INFLAMMATORY DISORDER, BRONCHOPULMONARY DYSPLASIA, ASTHMA, RESPIRATORY COMPLICATIONS
Exhaled nitric oxide (eNO) is a non-invasive marker of eosinophilic airway inflammation clinically used in adults and school-aged children with asthma [Nitric oxide (NO) is generated by the oxidation of L-arginine by nitric oxide synthase (NOS) by epithelial, inflammatory and vascular endothelial cells in the respiratory tract [In addition to asthma, elevated eNO has been reported in other inflammatory disorders in infants: established bronchopulmonary dysplasia [eNO has been shown to be lower in infants with prenatal tobacco exposure (PTE) [The Bern Basel Infant Lung Development (BILD) cohort study [While there is no published data on the effect of recent (seven days or less) exposure to air pollutants on eNO in infants, elevated eNO in children has been associated with recent exposure to environmental air pollutants including NOInfants born to mothers with asthma in pregnancy have higher rates of respiratory complications after birth [