4.4. Masking and Drug Administration
The random assignment sequence for the administration of antioxidants was generated at the coordination center using a computer-generated randomization program. The pharmacy maintained the blinding. Blinding was also carried out from the study’s beginning until the results’ analysis. A pharmaceutical professional maintains surveillance and care of the form of application of each of the antioxidants according to the type of absorption and interactions with other medications and the most appropriate way to administer them under the conditions that each patient requires.All antioxidants were administered orally or through a nasogastric tube for 5 days in addition to standard therapy. NAC was administered in 1200 mg tablets every 12 h. In addition, patients were given 50 mg of MT in 5 mg tablets once a day and vitamin C in 1 g effervescent tablets every 6 h. Vit E capsules of 400 IU were administered every 8 h. The preparation and administration of these drugs is presented in The pharmacotherapeutic follow-up of the antioxidants used in the clinical trial had strict surveillance of the administration of medications by the CMABC Pharmacy Department to establish that antioxidants were administered as much as possible under the same conditions, both in the preparation and preparation administration hours (