Total anti-SE36 IgG response
Anti-SE36 antibodies were detected before vaccination in both arms across the three cohorts. Four weeks after each vaccination, the BK-SE36/CpG arms had markedly higher mean anti-SE36 antibody titres compared to the control arm (Total anti-SE36 IgG antibody.Subjects were vaccinated at Day 0 (Dose 1), 28 (Dose 2) and 112 (Dose 3). Day 28, 56 and 140 = 4 weeks after Dose 1, 2 and 3, respectively. GMT, geometric mean titre (95% confidence interval); n = no. of subjects.Fold change in antibody titres from Day 0. In the 3 age cohorts, fold change in antibody titres from baseline were calculated by dividing the titre at subsequent visits by the titre at Day 0 (prior to Dose 1). The value of 8 was assigned to undetectable titres when calculating the fold change. In Cohort 1 (21-45 years old), the proportion of subjects with detectable anti-SE36 IgG titres prior to vaccination was comparable between treatment arms: 77% (BK-SE36/CpG) In Cohort 2 (5-10 years old), the proportion of subjects with detectable anti-SE36 IgG titres prior to vaccination was also comparable: 50% (BK-SE36/CpG) Likewise, in Cohort 3 (12–24-month-old), the proportion of subjects with detectable anti-SE36 IgG titres prior to vaccination was comparable between treatment arms: 26% (BK-SE36/CpG) 