Introduction
tumor
PROLIFERATION, TUMOR, SOLID TUMORS, TUMOR ANGIOGENESIS
Methionine aminopeptidase 2 (MetAP2) is one of two cytoplasmic methionine aminopeptidases ubiquitously expressed in mammalian cells. MetAPs catalyze N-terminal methionine excision from newly formed proteins, an essential step in cotranslational protein maturation ensuring protein stability and functionality. MetAP2 has been shown to play an essential role in the growth and proliferation of endothelial cells during tumor angiogenesis and tumor cell proliferation (Thus, MetAP2 could be a promising target in oncology (M8891 represents a novel class of orally bioavailable, potent, selective, and reversible MetAP2 inhibitors (We conducted this phase I study to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of M8891 monotherapy in patients with advanced solid tumors.