Interpretation of scores: meaningful within-patient improvements
Thresholds for meaningful within-patient change were derived to determine the proportion of responders for subsequent unblinded analyses. Anchor-based analyses were performed for individual and overall VAS symptoms and both composite VAS scores and the SNOT-22 total score using data from baseline to Week 52. Potential anchors included in this exploratory analysis were endoscopic NP score, PNIF, overall VAS and SNOT-22, none of which have been established as verified anchors and no meaningful changes have been reported for overall VAS and endoscopic NP scores. Polyserial correlations were used to assess the relationship between potential anchors and change in VAS scores; anchors with a coefficient of ≥ 0.3 were selected [