INTRODUCTION
NHL, non‐Hodgkin lymphoma, DLBCL
LYMPHOMA, ABNORMAL DNA METHYLATION, DISEASES, NHL
Diffuse large B‐cell lymphoma (DLBCL) is the most common subtype of non‐Hodgkin lymphoma (NHL), accounting for approximately 30%–40% of cases. The current standard treatment is the R‐CHOP regimen, although 30%–40% of patients relapse or develop refractory diseases.Recently, abnormal DNA methylation was found to be related to the development and chemoresistance of lymphoma.