Sleep, anxiety, menstrual flow, depression, and perimenopausal interference
depression, anxiety
Calendar records of “sleep problems” and “feelings of anxiety” were not different at the 3rd-m between women by randomization. However, women perceived that “sleep quality” was significantly improved on progesterone versus placebo (Fig. Perimenopausal women’s perceived changes in menstruation and sleep by progesterone (blue) or Placebo (black) 3-Month Randomized Therapy. The solid line is the median with the box including 50% (25th to 75th percentiles). Negative ratings, as analyzed by Wilcoxon rank-sum test, refer to decreased and positive relate to increased respective experiences.The PHQ-9 (for depression) and Perimenopause Interference Questionnaire data did not differ by random therapy assignment at baseline (Table Early and Late Perimenopause participants’ VMS and Perceived Change results are shown in Supplemental Table 