Data collection
nausea, bradycardia, choking, airway obstruction, respiratory adverse, postoperative nausea and vomiting, loss of consciousness, ataxia, vomiting, apnea, abnormal respiratory movements, diaphragmatic spasm, hypotension, Hypotension
ADVERSE EVENTS, CHOKING, AIRWAY OBSTRUCTION, CHOKING, BLOOD
From the start of the administration, time to loss of consciousness (LOC), examination start time, additional drug time, examination start time (i.e., the timer started at endoscope removal for 10 minutes and 20 minutes), recovery time (wake-up command at medium volume + tap on the shoulder), the dose of drugs used during the examination and the reason for additional drugs were recorded. Blood pressure, heart rate, respiration, and oxygen monitoring: 3 measurements were taken in the left lateral position within 30 minutes before examination, and the average value was taken as the baseline value. Blood pressure, heart rate, respiration, and oxygen saturation were measured after administration of the test drugs, and then set to be measured and recorded every 2 minutes until the end of the procedure, while the MOAA/S score was evaluated every 3 minutes, and the patient’s blood pressure was measured and recorded at the end of the procedure (when the endoscope was withdrawn), recovery time, and every 10 minutes after the procedure until the subject met the criteria for discharge with an Aldrete score of 9 or more reached. Record if first aid treatment is available. Assessment of the quality of recovery included the Steward score, orientation score, head-up assessment, modified Bromage score, and ataxia scale. The evaluation investigators assessed the steward score, orientation, head-up assessment, and modified Bromage score sequentially 30 minutes before the examination, 10 minutes after the end of the examination, and 20 minutes after the examination.For the collection of adverse events, we defined the adverse events that occurred in this study in a uniform manner. Hypotension was defined as MAP <65 mmHg or a decrease of more than 20% in patients after drug administration, and hypotension requiring treatment was defined as a decrease of more than 30% in blood pressure; body movement was defined as body movement visible to the naked eye of the investigator; postoperative nausea and vomiting was defined as the direct occurrence of vomiting in patients or verbal reports of nausea by patients; Choking was defined as the patient’s choking response during endoscopic insertion; Hiccup was defined as the manifestation of diaphragmatic spasm in patients after medication administration; respiratory adverse events included: oxygen saturation <95%, respiratory count <12 breaths/min, apnea, and upper airway obstruction (defined as abnormal respiratory movements of the patient’s thorax directly observed by the investigator), bradycardia was defined as a heart rate <50 beats/min on ECG monitoring, and all adverse events were defined by the investigator.