Interim analysis
The TU dose was based on limited clinical observations of pubertal induction, with doses of 1/4–1/5 of those used for replacement therapy in adult men. An interim analysis of testosterone levels in five patients in the TU group was conducted to explore the possibility of titrating the TU dose up or down for the rest of the study, to avoid overly high or low dosages. The aim of TU treatment was to achieve testosterone levels in the lower range found in mid-puberty (4–9 nmol/L), 2 months after the start of injections (