Introduction
psychiatric, substance dependence
REGRESSION, CORTEX
Psychedelics like psilocybin and lysergic acid diethylamide (LSD) have emerged as promising new treatment candidates for a variety of psychiatric conditions including substance dependence [Functional connectivity (FC) [Firstly, FC is an undirected measure of connectivity, because computation of the correlation coefficient is commutative. Secondly, it ignores two important organisational principles of the cortex: (1) the asymmetry of connections [In this exploratory analysis, we estimated whole-brain EC using regression dynamic causal modelling (rDCM; [To assess this, we also compared FC and EC in terms of their ability to distinguish LSD from placebo at the individual level. In future studies, these computationally-informed biomarkers could potentially be leveraged to predict the subjective effects of psychedelics.