Statistical Analysis
depression
ADVERSE EFFECTS
All analyses were performed according to a modified intention-to-treat principle, meaning that patients were included if at least 1 TCA dose was administered. The primary analysis was presented in a Kaplan-Meier survival curve and conducted using a 2-sided log-rank test. In case no therapeutic plasma concentration was reached during the study, censoring was applied. We performed subgroup analyses per antidepressant (nortriptyline, clomipramine, and imipramine). Secondary outcome measures were analyzed through linear mixed-model analyses using a linear time trend (weeks of treatment) and the interaction term between study group (PIT or control) and time as an independent variable. We examined the interaction between treatment group and time for both depression severity (HAMD-17 score) and frequency and severity of adverse effects. Independent 