Author contributions
L.M.W., B.D.H., B.K. and K.D. conceptualized and designed the study. L.M.H., X.Z. and L.M.W. wrote the manuscript. X.Z. performed the analyses. L.M.H., B.D.H, P.J.vR. and R.H. monitored the ketamine infusions as licensed clinicians. N.J.G. and C.B. acquired the data. T.S., P.J.vR., J.A.Y., C.I.R., B.K. and K.D. critically reviewed the manuscript. All authors participated in the discussion and revision of the manuscript and approved the final manuscript. L.M.W. supervised the overall project and L.M.H. supervised the clinical components of the project.