Ethics approval and consent to participate
The study was performed in accordance with the Declaration of Helsinki, ethical approval was approved by the Institutional Review board of the Medical University of Innsbruck, Austria (approval number AN 2015–0005 345/4.13, first registered 29/04/2019). The study is registered at All study participants provided written informed consent. In case they were younger than the age of 18, a written informed consent was signed by the parents or the legal guardian.