Authors’ contributions
NBJ
NBJ executed and planned the study, contributed to data collection, conducted statistical analyses, and wrote the manuscript. MLJ executed the study and contributed to data collection. JR collected data, contributed to patient referrals, and revised the manuscript. MS, MD and TK performed the echocardiographies and critically revised the manuscript. MS designed and planned the trial, collected and interpreted the data. PR designed the trial, analyzed and interpreted the data, and critically revised the manuscript. JF planned the trial and critically revised the manuscript. CK conceptualized and planned the trial, wrote grant applications, and wrote the manuscript. CK, the guarantor of this work, has access to all the data and takes responsibility for the integrity of the data and the accuracy of the data analyses. All authors read and approved the final manuscript.