Author contributions
S.R.S., R.K.-B., K.D.C., and B.E.R. designed the study. K.D.C. and E.A.C. executed the trials and supervised data-generating cores. F.Y., D.I., and B.D. performed statistical analyses. A.M. and T.D. performed mathematical modeling supervised by B.E.R. and R.K.-B. B.D. performed metagenomic analysis, supervised by R.K.-B. K.D.C. wrote the paper with critical revision and input from E.A.C., B.D., D.I., F.Y., A.M., T.L.D., R.E.P., B.E.R., R.K.-B., and S.R.S. S.R.S. provided overall supervision for the clinical trial execution. S.R.S., R.K.-B., and B.E.R. secured grant funding.