Results
stroke, death
CVD, STROKE
Among 9896 participants with at least one follow-up visit during a median follow-up of 4.2 years (min: 0.05, max: 4.5 years, 35,583.9 total person-years), 847 primary outcomes including 524 MI or stroke and 323 CVD mortality occurred. The incidence rate of fatal or non-fatal cardiovascular outcomes was 285 in the standard and 221 in the intensive therapy per 10,000 person years, respectively. The rate of all-cause death was 301 per 10,000 person-years in the standard therapy as compared with 134 per 10,000 person-years in the intensive therapy. The rate of CVD mortality was 13 per 10,000 person-year (22.3 per 10,000 in the standard vs 10.4 per 10,000 in the intensive therapy).Overall, 6543 participants (64.1%) had at least one noncompliance of assigned treatment during their visits (82.4% in the standard vs 45.9% in the intensive group). Table Distribution of baseline demographic and treatment assignment status among complier and non-complier participants.Values are percent unless otherwise indicated.The noncompliance of treatment protocol per visit was also different between the two groups. The rate of noncompliance was 66.4% (41,239 person-visits) in standard therapy group as compared with 16.7% (10,341 person-visits) in the intensive-therapy group (P-value < 0.001), while there was no substantial difference in the loss to follow-up between the two groups (7.4% and 7.5% in the standard and intensive therapy, respectively).Table Adjusted odds ratios (95% confidence intervals) of treatment noncompliance by treatment arm.Table Hazard ratios of CVD outcome, all-cause, and CVD mortality for intensive compared to standard therapy in the ACCORD trial.