Discussion
high-grade burn injuries, necrotic, infection, burns, necrosis burns, necrosis
INFECTION, NECROTIC, NECROSIS
This study is the first clinical trial to compares the therapeutic potency of maggot debridement therapy (MDT) for full-thickness (grade-III) burn injuries versus conventional treatment regimen. We found that patients who received maggots had significantly improved granulation and decreased necrosis within the same timeline compared to the conventional treatment group. As it is summarized in Table On the other hand, these maggots can also scavenge microbial infection from the affected surface. In addition, To minimize the bias, we also performed a subgroup analysis for patients who had > 50 necrosis at the baseline, to investigate whether MDT or conventional treatment could be more potent in high necrosis burns. Of particular note, we found that MDT had a significant superiority to conventional regimen in treating high necrotic wounds. We defined a novel index of granulation/necrosis (g/n) to elucidate the efficacy of MDT in comparison to routine treatment for grade-III burns. As shown in Fig. Bacterial contamination of high-grade burn injuries is also another matter of importance which affect the treatment length, as well as the final outcome [