Author contributions
NSR
SMC, EMG, MAR, PSA, MI, JLP and NSR participated in the conception, design, data acquisition; AP, SMC and PSA have performed statistical analyses and data interpretation. All authors were involved in the interpretation of data and drafting, revision of the manuscript and approval of the final version of the manuscript and agreed to be accountable for all aspects of the work. Everyone who contributed significantly has been listed as authors. All authors meet the criteria for authorship stated in the Uniform Requirements for Manuscripts Submitted to Biomedical Journals.