3.3. Statistical Analyses
SECONDARY
To compare baseline characteristics between treatment groups we will use the Chi square test and ANOVA. We will conduct longitudinal analysis on the primary and secondary outcomes, with treatment groups as independent variables. To account for clustering within the individual due to repeated measurements, we will use mixed-effects models. We will conduct ‘intention to treat’ analysis and per protocol as a sensitivity analysis.All statistical analyses will be carried out using R, version 3.5.3 (R Core Team, 2016) and SPSS Statistics, version 29.0.0.0 (IBM, Armonk, NY, USA).