4.2. Study Design
A randomized, double-blind, placebo-controlled dietary intervention trial of 12 months duration was designed to evaluate the effects of equol and resveratrol supplementation on bone markers of in menopausal women. Of 90 eligible women, 12 were excluded because they did not meet the inclusion criteria, and 2 declined to participate (The study protocol was approved by the local ethics committee (study code: SI.02.DS.L; ref. no. 2011/3) and registered at the ISRCTN registry (ISRCTN10128742). All subjects provided written informed consent prior to the initiation of any study-related procedures.