Patient selection and study design
PD
MAY, EMD
For this prospective, 1:1 randomized, double-blinded, controlled clinical trial, patients were consecutively recruited from September 2020 to May 2022 at the Division of Conservative Dentistry and Periodontology, Medical University of Vienna, Austria. The ethics committee (Ethics Commission of the Medical University of Vienna) provided approval for this study (1248/2020), and the study was registered at clinicaltrials.gov (Of 41 patients that were assessed for eligibility, 19 did not meet inclusion criteria. A total of 22 systemically healthy patients were enrolled as per protocol and randomly assigned to the test group, who received EMD (EMD + ; CONSORT flow chart of the study design. Evaluation of clinical parameters (PD, CAL, PI, BOP), oral hygiene indices (API, PBI), cytokine analysis, and microbial assessments were performed at baseline and at 6-month follow-up