Dose and treatment duration
The National Prescription Registry does not include information on the prescribed daily dosage of the medication, but rather the date of dispensing, strength, and quantity. Among 5-year survivors, we created an algorithm, in which a minimum, maximum, and typical daily dosage of used medication was defined for each RASi, BB, and MRA dispensed between 1 January 2004 and 31 December 2018. Based on methods described previously [