3.1. Enrollment of Study Participants
A total of 111 participants were initially screened for the study. Among them, 13 individuals were deemed ineligible for enrollment, with two not meeting the inclusion criteria, five declining to participate, and four failing to confirm their availability for the baseline visit. Ultimately, 98 participants, including 37 healthy and 61 overweight/obese individuals, were enrolled and allocated into low- and high-dose groups after providing informed consent. Among these participants, 82 individuals, comprising 30 healthy and 52 overweight/obese individuals, completed the 10-day intervention and were included in the efficacy analysis. The study demonstrated high compliance, with over 90% completing the intervention, thus highlighting their high acceptability of the NRE intervention. The trial flow chart of the study can be found in 