Introduction
arteriolar disorder, neuropsychiatric and mood disorders, lacunar ischemic strokes, lacunar ischemic stroke
VASCULAR DEMENTIA, CEREBRAL SMALL VESSEL DISEASE, ISCHEMIC STROKES
Cerebral small vessel disease (cSVD) causes lacunar ischemic stroke (25% of ischemic strokes), vascular dementia, and neuropsychiatric and mood disorders and impairs mobility.Most lacunar ischemic strokes and cSVD are thought to result from an intrinsic perforating arteriolar disorder,Isosorbide mononitrate (ISMN), a nitric oxide (NO) donor, augments the NO-cyclic guanosine monophosphate phosphodiesterase PDE5-inhibitor pathway.To inform the design of large phase 3 trials, the Lacunar Intervention Trial-2 (LACI-2) aimed to evaluate trial feasibility, retention, and adherence to ISMN and cilostazol as well as their safety, tolerability, and effects on common clinical outcomes in patients with lacunar ischemic stroke.