Discussion
hyperoxia, hypoxaemia, hyperoxaemia
PID
This study will compare the effectiveness of closed-loop automated oxygen control to manual oxygen control in ventilated infants born at or above 34 weeks of gestation. To date, studies on CLAC have included very preterm or low birth weight infants [Several algorithms have been developed for automated oxygen control and it is likely that differences in their design influence their performance. The ‘Oxygenie’ controller used in this study follows a proportional integral derivative (PID) algorithm. In preterm infants on respiratory support, the Oxygenie controller was more effective in keeping oxygen saturations within the target range and preventing hyperoxaemia and hypoxaemia when compared with a hybrid rule-based adaptive controller (CLiOParticipants are enrolled in our study within 24 h of initiation of mechanical ventilation. This limits the time frame to approach parents and obtain informed consent on participation but will provide more data points available for analysis as the duration of mechanical ventilation in infants born at or near term may be relatively short.Previous studies investigating compliance with achievement of SpOIn conclusion, if this study demonstrates that CLAC reduces hyperoxia and the overall duration of oxygen treatment in more mature infants, that could help improve clinical outcomes and reduce morbidity in this population.