Author contributions
XS: Formal analysis, data curation, visualization, writing of the original draft. LX: Clinical trial implementation, specimen collection. ZQZ: Conceptualization, design of methodology. YTY and PXL: Formal analysis, software testing and verification. TM and SG: Supervision of clinical trial, manuscript revision. L-YK: Writing, critical evaluation and revision of the original draft, resource provision. ZHS: Conceived and designed the experiments. All authors contributed to the article and approved the submitted version.