Statistical methods
malaria
REGRESSION, MALARIA
The engagement team and trial staff documented meeting reports and recorded field notes during all engagement activities and throughout the trial implementation. These have been summarized in this manuscript.The effectiveness of the engagement strategies was determined through the proportion of forest goers participating at each stage of the trial: enrolment, compliance with trial drug intake and attendance at follow-up visits. The Pearson Chi-squared test and logistic regression were used to determine the factors associated with compliance and discontinuation of study drugs.At any time point during the follow-up period, when a participant indicated that they did not plan to return to the forest within the next month, a further 28 days of trial drug was distributed as a post-forest period terminal chemoprophylaxis and the participants were regarded as having completed the trial and complied with the trial procedures. If a participant had a clinical malaria episode detected by rapid diagnostic test at any time during the follow-up period, the participant received anti-malarial treatment according to national treatment guidelines. No further follow-up was required and the participant was regarded as having completed the trial. When a participant was away from the village and did not come for further follow-up to receive the trial drug, they were considered as being lost to follow-up. When a participant indicated at any time point during follow-up that they did not want to continue the drug they were classified as having discontinued taking the drug.