Introduction
diabetic dyslipidemia, Dyslipidemia, diabetes
PATHOGENESIS, DYSLIPIDEMIA, DIABETES
Dyslipidemia is an imbalance of lipids, especially cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides [On the other hand, Adipolin, assigned with the alias names CTRP12, FAM132A, and C1QTNF12, is a novel adipokine with anti-inflammatory and insulin-sensitizing properties that are predominantly expressed in adipose tissue [The common treatment options for diabetes in Iran include calorie restrictions, diet control, lifestyle management, regular exercise training, oral glucose-lowering medications, monotherapy with insulin administration, and combination therapy with insulin [Propolis, a natural resinous viscos mixture is made by In this single-blind, randomized, and controlled trial, we evaluated the role of the combined exercise training (aerobic and resistance training) along with consumption of the 500 mg propolis on the anti-inflammation activity, antioxidant, and oxidant status in diabetic dyslipidemia conditions in adult women. Interestingly, we analyzed the closest microarray datasets obtained from the GEO database to determine effective hub genes in the pathogenesis of diabetic dyslipidemia status and highlighted potent druggable cut-point protein for designing novel therapeutic strategies based on bioinformatics analysis and molecular docking.