3.5. Correlation of the risk score and tumor immune microenvironment
tumor, TCGA, CRC
TUMOR
The ESTIMATE algorithm was applied to investigate the correlation of the risk score and the immune microenvironment in CRC. Next, Stromal score, Immune score, and ESTIMATE score of all CRC patients were calculated. As is Figure Risk score was associated with tumor immune microenvironment. (A) The boxplot showed the difference of risk score in stromal score, immune score, and ESTIMATE score, respectively. (B) Cellular fraction of different immune cells between high- and low-risk groups in TCGA datasets. (C) The correlation among risk score and activated dendritic cells, activated memory CD4To identify which immune cells take part in immune response of CRC, CIBERSORT algorithm was used to investigate the correction of risk score and 22 immune cell type (Fig. 