Trial design
This was an experimental, randomized controlled trial. Participants were randomly allocated to an experimental group or a control group for 6 weeks of intervention. This study was approved by the Institutional Review Board of Cheng Hsin General Hospital (425-103-02) and registered on 13/11/2016 at Thai Clinical Trials (registration number TCTR20161113001) and consistent with the CONSORT checklist. All experiments were performed in compliance with applicable guidelines and regulations.