Statistical analysis
REGRESSION
Data for continuous variables are presented as mean ± standard deviation, if normally distributed, or as median and interquartile range (IQR) if non-normally distributed. Distribution was tested using Shapiro–Wilk tests. ANOVAs or Mann Whitney U tests were used to compare continuous variables. Categorical variables were compared with ChiBinary logistic regression analysis for the prediction of iASD closure was done including continuous and categorical variables. A receiver-operating characteristic analysis was performed to calculate thresholds and the area under the curve (AUC).All time-to-event endpoints were defined with time of randomization as time zero. A 