4.1. Efficacy
postoperative pain, fever, pain
In the present study, a meaningful result was that intermittent intravenous administration of ibuprofen starting 30 min before the end of surgery significantly narrowed morphine consumption compared with placebo, also reduced patients' postoperative VAS and the AUCs of VAS both at rest and movement. What's more, patients treated with dose of IVIB 400 mg or 800 mg, earned statistically higher satisfaction than placebo group, and lowered the body temperature. Early clinical trials have demonstrated that IVIB administered over 30–60 minutes is highly effective in treating pain and even fever [The findings of the present study were that IVIB may provide effective analgesia, regardless of 400 mg or 800 mg, when administering pre-emptively during the perioperative period. Interestingly, we found that the dose was different in previous studies of single-dose treatment of postoperative pain. Homologous conclusions are supported by two systematic reviews and meta-analyzes published in recent years [