Comparison
REGRESSION
To illustrate the benefit of conducting a delocalized analysis, a simulation study based on the fMRI data collected in the tDCS study was conducted. We demonstrate an extreme example where non‐localized brain stimulation decreases statistical power, or even makes it impossible to identify ROI pairs with a significant effect when implementing a localization method. However, using connectivity densities retains the relevant information. Our goal in this simulation was to create a caricature of non‐localized effects, to demonstrate the statistical direction that the procedure highlights.As a correlation coefficient, connectivity can be written as A non‐localized “stimulation” was simulated by perturbing region For every run of the simulation, we sampled 50 pre‐stimulation maps from the pre‐intervention scans and fit the parameters The edgewise regression approach considers the following model: