Quantifying the role of extant nAb titers in vaccine induced protection
We deconstructed the total vaccine effect as the product of an extant nAb titer effect times all other vaccinal effects beyond extant nAb titer. The analysis suggests that at a predicted neutralization titer of 1000 IU50/ml, the percent of total vaccine efficacy due to extant antibody was 72% (95% CI: 50%, 100%) and the probability that a person protected by the vaccine would have been protected by the mAb at the same titer level was 0.95 (95% CI: 0.86, 1.00) (Supplementary Sections 