Introduction
POCD, hypotensive, hypotension, Postoperative cognitive dysfunction
HYPOTENSIVE, VASODILATATION
Postoperative cognitive dysfunction (POCD) has gained much attention in the past years. Despite the great strides in anesthesia and surgical techniques over the past decades, POCD is still highly prevalent [Deliberate hypotensive anesthesia is necessary during maxillofacial and septoplasty surgery for drying surgical field, ease in operation procedure and shortening of the duration of surgery. However, deliberate hypotensive anesthesia is associated with increased risk of impaired perfusion to important organs, such as the brain [The mechanism of the hypotensive action of phentolamine is mediated through its nonselective α-adrenergic antagonist activity, resulting in a decrease in peripheral vascular resistance and vasodilatation. [Neuropsychological tools are classically used to investigate POCD. The optimal cognitive battery is one that includes highly sensitive different tests, each targeting a specific cognitive area [This work aimed to compare the effect of deliberate hypotensive anesthesia using nitroglycerine versus phentolamine on ERPs and cognitive function in patients undergoing septoplasty surgery to select the most appropriate agent to induce hypotension.