Non-inferiority
Depression, fatigue, Fatigue
SECONDARY
Change scores and differences between treatment groups on all outcomes are reported in Mean change scores of the primary and secondary outcome measures and the differences between treatment groups corrected for baseline.CBT: cognitive behavioural therapy; CI: confidence interval; CIS: checklist individual strength; FSS: fatigue severity scale; SF36: short form 36; SIP: sickness impact profile; WSAS: work and social adjustment scale; BDI: Beck Depression Inventory.Clinically relevant change = either CIS fatigue post-treatment < 35, or a minimal change of 8 points on the CIS fatigue.Fatigue severity pre- and post-treatment in both treatment conditions (mean and 95% CI).In the face-to-face group, 63.8% of the patients showed a clinically relevant improvement of fatigue severity, and 66.6% in the blended condition (63.6% in the TREFAMS-CBT studyPost hoc ITT analysis, excluding (