Ethics approval and consent to participate
All procedures performed in this study involving human participants were in accordance with the ethical standards of the Ethics Committee of the State Medical Association of the Rhineland-Palatinate and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors. The study was registered in the German Clinical Trials Registry (DRKS00010510), approval was given by the Ethics Committee of the Rhineland-Palatinate State Medical Association (837.155.16/10474). Informed and signed consent was obtained from all individual participants included in the study. Additional informed consent was obtained from all individual participants for whom identifying information is included in this article. Data collection, coding, routing and analysis were in accordance with legal data protection policy.