Ethics approval and consent to participate {24}
This study protocol was approved by the Ethic committee of the Ludwig-Maximilians-University of Munich, Germany and by applicable ethics committees of the trial sites. These include:South African Health Products and Regulatory Authority, Arcadia, South AfricaHuman Research Ethics committee, University of the Witwatersrand (Ref 200910B)Medical Research Coordinating Committee Tanzania (Ref NIMR/HQ/R.8a/Vol.IX/3649)Mbeya Medical Research and Ethics review committee, Mbeya, Tanzania (Ref SZEC-2439/R.A./V.1/105)Institutional Review Board, Ifakara Health Institute, Dar es Salaam, Tanzania (Ref IHI/IRB/AMM/ No: 11-2021)Kilimanjaro Christian Medical College Research Ethics and Review Committee (CRERC), Moshi, TanzaniaWritten informed consent will be obtained from each participant or its legal guardian. The informed consent is available from the corresponding author on request.