Linear models adjusting for wash-in and wash-out
REGRESSION
To reduce the bias due to carry-over, we adjust the multiple linear regression model for wash-in Let With that, As For an illustration, Fig. Illustration of the treatment effects with carry-over for a simulated patient. The patient was exposed to treatment 1 until day 14. Starting on day 14, the treatment effect of treatment 1 washes out and converges to 0 as the treatment was not given anymore. At this point, the patient started the second treatment period. With being exposed to of treatment 2, the effect of treatment 2 washes in and it takes time until it reaches the full effect on the outcome