Ethics approval and consent to participate
This protocol was approved by the ethics committee of Mazandaran University of Medical Sciences, Iran (IR.MAZUMS.REC.1396.2950). The study was performed and reported following the Consolidated Standards of Reporting Trials (CONSORT) Statement. All eligible patients, who met the criteria of interest, were given the necessary knowledge of the experiment details. Informed consent was obtained from all participants. All experiments were performed in accordance with relevant guidelines and regulations.