Protection against all cholera episodes and severe cholera episodes in the population evaluated for overall OCV protection
diarrhoea
CHOLERA
A total of 442 confirmed cholera episodes, 171 severe, were diagnosed in the study population assessed for overall OCV protection during the 2 years of the follow-up. Two hundred fifty-nine cholera cases (106 severe) occurred among the residents in control clusters, and 183 cases (65 severe) occurred in OCV clusters (Protection against all cholera and severe cholera episodes in residents of OCV versus control clusters or by residence in Better or Not Better WASH households in the population evaluated for overall OCV protection.Person-years.Protective effectiveness.One-sided p-value calculated using Cochran–Armitage test.Adjusted for closer distance from the household to the nearest icddr,b hospital, age at zero time (years), household average expenditure, individuals living in their own house, individuals living in a household with only one room, individuals living in a household with a concrete roof, individuals having reported diarrhoea within 6 months at the time of household registration, total number of household members, household wash status.Adjusted for closer distance from the household to the nearest icddr,b hospital, age at zero time (years), household average expenditure, individuals living in their own house, individuals living in a household with only one room, individuals living in a household with a concrete roof, individuals having reported diarrhoea within 6 months at the time of household registration, total number of household members, residence in a vaccine versus control cluster.We further analyzed the combined overall protective impact of OCV and “Better WASH” against all cholera and severe cholera by the four possible categories of the two variables: residence in a “Not Better WASH” household in a control cluster; residence in a “Better WASH” household in a control cluster; residence in a “Not Better WASH” household in an OCV cluster; and residence in a “Better WASH” household in an OCV cluster. Relative to residence in a “Not Better WASH” household in a control cluster, residence in a “Better WASH” household in an OCV cluster was associated with 41% (95% CI: 13, 59) protection against all cholera episodes and 48% (95% CI: 16, 67) protection against severe cholera episodes (