Discussion
osseous defect, tooth
The 1980s saw the introduction of bone grafts in fresh sockets for ARP (Thus, novel bio-active methods have been devised to counteract the limitations of previous bone graft substances. Autogenous growth factors are mostly derived from platelets. Growth factors such as PRP, PRF, and CGF are bioactive proteins that regulate the mechanism of bone and soft tissue regeneration (The current prospective, split-mouth, randomized, controlled clinical trial confirmed that sockets grafted with CGF had better preservation of the alveolar ridge and a reduction of periodontal pocket depth, compared to natural healing (The comparison between both sides immediately after extraction, followed by a CBCT three months later. In terms of bone resorption, the present findings showed significant differences (P<.001) for resorption between C1 and C2 in the control site; buccal wall, lingual wall heights, and alveolar bone width showed a statistically significant reduction in the control site C2 when compared to baseline C1 of the same site, while CGF sites showed a significant increase of the wall heights and width. This emphasizes the outcomes of previous studies, one of which reported that the application of CGF may reduce both vertical and horizontal bone resorption after posterior tooth extraction (In terms of bone density, Ma et al. (Jung et al. (Based on a slew of studies, traditional therapy for the extraction of impacted third molars often leads to the development of an osseous defect at the distal aspect of the second molar, which may need a surgical repair later (In summary, compared to PRP and PRF, CGF contains more growth factors (