Background
OMIM 219700, CF
CYSTIC FIBROSIS, PATHOLOGICAL PROCESSES, GENETIC DISORDER
Cystic fibrosis (CF, OMIM 219700) is a genetic disorder caused by mutations in the In CF, genetic and environmental factors determine a distinct lung microenvironment characterized by mucus plugging [Current clinical practice does not prevent permanent damage to the bronchial tree, which is evident in most school-aged children with CF [To establish if BA indicate early pathological processes in CF lung disease, this study was conducted to profile the inflammatory and microbial landscapes in BALF related to detection of BA. Bronchial wash specimens were collected from 12-month old infants with CF enrolled in the COMBAT-CF study, a placebo-controlled clinical trial with azithromycin [