Author contributions
P.H.
Conceptualization was the responsibility of E.F.-N., S.J.M., G.A.H., M.D.R., R.J.P., E.B., N.S., P.H., B.J.M., A.B., K.M., A.J.R., A.N.E., D.G.T., G.A.H., S.J.O., R.D., D.M.W., G.D.Y., E.M.W.E. and F.S.K. Methodology was the responsibility of E.F.-.N., C.P.-C., S.J.M., G.A.H., D.M.W., G.D.Y., E.M.W.E., F.S.K. and D.G.T. Software was the responsibility of K.M., N.S. and P.H. Validation was conducted by K.M., N.S., P.H. and B.J.M. Formal analysis was conducted by N.S., B.J.M., K.M., D.G.T., E.F.-N., C.P.-C., G.A.H., D.M.W. and G.D.Y. F.S.K. was the global principal investigator. E.M.W.E. was the lead clinical principal investigator. Investigation was carried out by M.D.R., R.J.P., R.K., P.O., T.F.-B., S.K., A.M., J.S.B., J.B.-C., K.M.D., E.B., P.G.R., M.A.M., L.T. and F.S.K. Resources were provided by Regeneron Pharmaceuticals. Data curation was carried out by K.M., N.S. and P.H. Writing of the original draft was carried out by E.F.-N., A.J.R., P.H., N.S., B.J.M., G.A.H. and D.G.T. Review and editing was carried out by M.D.R., E.F.-N., R.J.P., R.K., P.O., T.F.-B., C.R., S.K., A.M., J.S.B., J.T., M.S., J.B.-C., A.M.C., K.M.D., E.B., P.G.R., M.A.M., L.T., C.P.-C., N.S., P.H., B.J.M., A.B., K.M., S.M., A.J.R., A.N.E., D.G.T., G.A.H., S.J.O., R.D., D.M.W., G.D.Y., E.M.W.E. and F.S.K. Visualization was carried out by E.F.-N., A.J.R., P.H., N.S. and B.J.M. Supervision was conducted by E.F.-N., C.P.-C., D.G.T., R.D., G.A.H., D.M.W. and B.J.M. Project administration was carried out by E.F.-N. and C.P.-C. Funding acquisition was provided by Regeneron Pharmaceuticals.