Primary endpoints
stroke, hypertension, HT
REGRESSION, STROKE, HYPERTENSION
In both arms, HT occurred mostly within 24 h after IVT. In the ITT population, Cerebrolysin set a favorable trend to lower any HT with a rate of 15.9% versus 23.3% in the control group and a corresponding OR of 0.543 (95% CI: 0.281–1.05; Study endpointsLikewise, Cerebrolysin treatment resulted in a substantial decrease of symptomatic HT (ITT population: 3.2% compared to 9.3%; PP population: 2.6% compared to 9.0%) with an OR of 0.248 (95% CI: 0.072–0.851; In the ITT population, the NNT (benefit) to reduce any and symptomatic HT with Cerebrolysin was 13.545 (95% CI, 68.282 (harm) to 6.161 (benefit)) and 16.319 (95% CI, 8.536 (benefit) to 184.973 (benefit)), respectively.Similarly, in the PP cohort, the NNT (benefit) was 10.86 (95% CI, 5.50 (benefit) to 420.68 (benefit)) and 15.65 (95% CI, 8.33 (benefit) to 129.10 (benefit)), respectively.Although the arms were imbalanced in age, history of hypertension and previous stroke, the differences had no effect on the primary endpoints after adjustment in a multivariate logistic regression model. In fact, the NIHSS and ASPECTS were determined as significant confounders for any HT, while symptomatic HT was confounded by the NIHSS (Fig. Primary endpoints. Univariate and multivariate logistic regression. Crude and adjusted OR with CI are reported. Solid markers – intention-to-treat population (