Statistical Analysis
tumor
REGRESSION, DISEASE, TUMOR
Continuous end points were summarized using median and IQR, and the Hodges-Lehmann estimator with corresponding 95% CI was used to report differences between treatment arms. Categorical end points were summarized using frequency counts and percentages as well as differences in proportions between treatment arms with corresponding 95% CI. Due to the exploratory nature of this analysis, no hypothesis testing was performed. To assess the association of treatment arm with the administration of adjuvant systemic therapy and chemotherapy, unadjusted odds ratio (OR) as well as adjusted OR (aOR) with corresponding 95% CI for palpable vs nonpalpable disease, menopausal status, tumor subtype, tumor grade, age, year, and country were calculated using logistic regression models. All analyses were performed using R, version 4.2.1 (R Project for Statistical Computing).