Study Design and Participants
virologic failure
ARTIST is a noncomparative, randomized, double-blind, placebo-controlled, phase 2, 48-week trial of second-line TLD with or without a lead-in supplementary dolutegravir dose in patients with virologic failure on first-line TEE. A detailed protocol describing our methods has been published [Eligible patients were adults (≥18 years old) with virologic failure (defined as 2 consecutive human immunodeficiency virus type 1 (HIV-1) RNA ≥1000 copies/mL 2–24 months apart) on a first-line regimen of tenofovir, emtricitabine (or lamivudine), and efavirenz. Exclusion criteria were CD4