Statistical analysis
Hypotensive, hypotensive
HYPOTENSIVE, EDWARDS, SECONDARY, EVENTS, HYPOTENSIVE, COMPLICATIONS
Continuous data are presented as medians with interquartile ranges (25th to 75th IQR). Categorical data are presented as frequencies with percentages. Normality distribution of a variable was assessed graphically and with the Shapiro–Wilk test.Hypotensive events (defined as a MAP < 65 mmHg for > 1 min) and severe hypotensive events (defined as a MAP < 50 mmHg for > 1 min) were analyzed in terms of number, duration, area under the threshold of 65 mmHg and 50 mmHg, and TWA of the area under the threshold. The area under the curve (AUC) MAP below a threshold was calculated as the cumulative sum of the areas below the given threshold for a patient using the trapezoid rule and measured in units of mmHg times minutes [Continuous primary and secondary outcomes were compared using 2-sample Wilcoxon rank-sum test and Hodges Lehman estimation of location shift with corresponding asymptotic 95% CI, as the variables were not normally distributed. Differences on secondary categorical outcomes were assessed with the Chi-square test or Fisher’s exact test in case of expected frequencies < 5.Postoperative explorative outcomes including major complications before hospital discharge and 30-day mortality were evaluated by reviewing in-hospital electronic medical records or by contacting the patients by telephone and were reported as number and proportion.Data analysis was performed using R (R Foundation for Statistical computing, Austria, version 4.1.2), Matlab (The MathWorks Inc, Natick, MA, USA) and Acumen Analytics software (Edwards Lifesciences). A 2-sided probability value of 