Introduction
death, diarrhea, stomatitis, cancer, gastritis, head and neck cancer, Chemotherapy-induced OM
SIDE EFFECT, ORAL MUCOSITIS, STOMATITIS, CANCER, GASTRITIS, SECONDARY, HEAD AND NECK CANCER, BONE MARROW SUPPRESSION, ORAL INFECTION
Oral mucositis (OM) is a side effect associated with cancer treatment. The incidence of OM is 20% to 40% in patients undergoing conventional chemotherapy, 60% to 85% in those undergoing hematopoietic stem cell transplantation (HSCT), and almost 100% in those undergoing chemoradiation therapy for head and neck cancer [Numerous reports focusing on prevention or treatment of OM secondary to cancer therapy have been published [Chemotherapy-induced OM is associated with direct damage of mucosal tissues by cell death and the development of secondary oral infection due to bone marrow suppression [Hangeshashinto (HST), a Kampo medicine, was originally prescribed to treat diarrhea, gastritis, and stomatitis. HST contains seven extracted crude drugs (