Discussion
TRD, Pain, inflammation, ’ mood, pain, infection, hallucination, depression
INFLAMMATION, INFECTION
Pain in the perinatal period is one of the factors leading to the development of PPD. The symptoms of PPD are more prominent in women who experience frequent pain during childbirth [The traditional treatment for depression is to increase the amount of serotonin in the synaptic space to achieve the effect of alleviating depression, but these antidepressants are slow to act, generally taking three to six weeks to achieve therapeutic effects [Another retrospective analysis have showed that both esketamine’s approval for use in TRD and longer-term safety data may position it preferentially above racemic ketamine, though the efficacy of esketamine compared to racemic ketamine remained unclear [As endocrine hormones, NE and E can affect the bodies’ mood by modulating the sensitivity of neuronal synapses and neurotransmitters [As a non-specific inflammatory marker, CRP reflects the stress and inflammation response of the human body. When infection and injury take place, CRP rises sharply in the plasma [Studies have shown the brain causes negative emotions by the clustering of the lateral halterate nucleus, where the excitatory transmitter is the N-methyl-D-aspartate (NMDA) receptor of the glutamate-gated ion channel [Esketamine has been used clinically for many years as an anesthetic drug, which is now also widely concerned as a new antidepressant. Considering the possible side effects such as nightmare, hallucination and abusement [There were some limitations in this study, such as the strong subjectivity of the PPD evaluation by EPDS. To minimize the subjective differences, the PPD valuator in this study was the same physician who did not participate in the specific study. Furthermore, the objective indicators such as levels of, NE, E, CRP, IL−6 and IL−10 were also combined in the study, which could better reflect maternal depression. Furthermore, the severity of PPD was not measured in this study, which would be content of next studies.