Institutional Review Board Statement
All animal experiments were performed according to the guidelines of the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health and approved by the Committee on the Care and Use of Laboratory Animals of Kyung Hee University (KHUASP(SE)-18-071). The protocol for a randomized, double-blind, placebo-controlled clinical trial for 24 weeks was approved by the Kyung Hee University Hospital Institutional Review Board (IRB) (No: KMC IRB 2018-06-055). Written informed consent was obtained from all patients.