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Prurigo nodularis, pruritic, itch, inadequate disease
PRURIGO NODULARIS, CHRONIC PRURITUS, SKIN CONDITION
Prurigo nodularis (PN), a chronic inflammatory skin condition characterized by intensely pruritic papulonodular lesions, substantially impacts quality of life (QoL)PN is driven by an itch–scratch cycle with an intensity and frequency of chronic pruritus among the highest reported in dermatologic and other pruritic diseasesPN represents a substantial therapeutic challenge, and inadequate disease control is common in this populationCase reports have shown successful treatment with dupilumab in PNIn two parallel phase 3 trials of similar design, LIBERTY-PN PRIME and PRIME2, we assessed the efficacy and safety of dupilumab in adults with PN that was inadequately controlled with topical prescription therapies (Extended Data Fig. 