Imaging analyses
Concerning the imaging analyses, only ROI-to-ROI analyses were used in the CONN toolbox, and post-hoc analyses and visualisations were done by extracted the connectivity values into an extern statistical software First, the existence and robustness of each studied network were tested at baseline (t0) in all participants (linear model). A density of connectivity within each network (ratio of connectivity: number of found connections/number of possible connections) superior or equal to 70% was consider as relevant for a functional network, since it is usually the threshold used to indicate a strong relationship in a correlation matrixSecondly, effect of group (A > B) was tested at baseline (t0) to confirm that there was no difference between groups at baseline, one again in each studied network (t-tests).Then, changes of connectivity after the first intervention (t0 > t1) inside each studied network were evaluated in all participants to look for a modification of network-connectivity caused by the intervention or control (FR or SM) (paired t-tests).Afterwards, changes of connectivity after the first intervention (t0 > t1) inside each studied network were evaluated between groups (A > B) to look for a group-effect in the change of connectivity of each network (ANOVAs). If significant results were found in the CONN toolbox, connectivity values of the concerned clusters of ROIs were extracted and used for post-hoc analyses.Finally, percentages of changes of connectivity ((t1 – t0)/t0 × 100) were calculated from the connectivity values of the clusters that changed after the intervention, as well as percentages of evolution of the electrophysiological measures and well-being assessment that significantly change after the intervention or control. Correlations were evaluated between these percentages (percentages of changes of connectivity and percentages of physiological changes) using Pearson or Spearman correlations, according to normality of data.The same previous analyses were planned for the second intervention (t2 vs t3).