Data availability
The complete de-identified patient data set are available under restricted access because they contain information on health records and making the data publicly available without additional consent or ethical approval might compromise patient’s privacy and the original ethical approval, and data access can be obtained by request from the corresponding author (peizengycmu@126.com). The timeframe for response to requests will be within two weeks. Data will be shared for non-commercial purposes, with investigator support, after approval of a proposal, and with a signed data access agreement. The trial protocol and statistical analysis plan are provided with the paper. 