Cu-IUD, LNG implant and DMPA-IM initiation induce distinct patterns of endocervical gene-expression
To assess the impact of initiation of contraception on the endocervical transcriptome, we identified DEGs induced after one month of contraception usage relative to baseline within each study arm in a longitudinal intention-to-treat (ITT) analysis (Supplementary Table 2). A total of 151 DEGs were induced by DMPA-IM (60 upregulated, 91 downregulated), 82 by LNG-implant (69 upregulated, 13 downregulated) and 907 DEGs by Cu-IUD initiation (542 upregulated, 365 downregulated) (DMPA-IM, LNG implant and Cu-IUD initiation induce distinct patterns of endocervical gene-expression. The results of the statistical analyses on differential expression of post-vs-pre comparisons, i.e. DMPA-IM vs. baseline, LNG implant vs. baseline, and Cu-IUD vs. baseline, have been shown by the different panels (DMPA-IM: 