Statistical analysis
The Kolmogorov–Smirnov test was applied to test the normality of the outcome variables. Pearson's χA flexible factorial model was constructed in SPM12 with treatment group and state (connected or disconnected) as factors. Two-way interactions between factors were modeled in the design matrix, and t-contrasts were generated to assess differences in regional brain activity between subjects classified as connected versus disconnected (i.e., state-related effects) within each treatment group. Conjunction analysis was used to investigate common and jointly significant state-related effects across selected treatments (