Randomization
A computerized block randomization method was used for randomization. Participants were randomized to receive pioglitazone 30 mg/day or empagliflozin 10 mg/day for 24 weeks. The intervention medications were sealed sequentially and numbered according to the allocation sequence. An independent staff generated the random allocation sequence and assigned participants to the study arms. The care provider was blinded to the intervention. Medications were supplied free of charge.