Immunogenicity analysis
The immunology results described are restricted to the per-protocol immunogenicity population, which did not include all values from the 4 participants who did not receive all 3 doses of study product, as described below. For these participants, specimens collected after the missed vaccine dose were excluded from the immunogenicity analyses. All comparisons between IgG and 3 IgG subclass (IgG1, IgG3, and IgG4) antibodies to the The RFor each individual and post-vaccination time point, the ratio of the post-vaccination antibody level to the baseline level was calculated (A post-hoc Cochran Armitage test of trend was performed to investigate a possible dose-response relationship in the proportion of total IgG seroresponders among participants receiving No imputation methods were planned for missing values.