4. Discussion
obesity
OBESITY, OBESE, DISEASE, OXIDATIVE STRESS, SAID, ATHEROSCLEROSIS
The mechanism of damage to the LDL fraction of cholesterol is associated with the development of atherosclerosis, a disease that very often interacts with obesity. It was shown that BMI values correlated significantly positively with blood MDA concentrations. The analysis involved obese individuals, so the high BMI value was due to excessively accumulated fat mass in these individuals [The results of our study indicate that control subjects who underwent moderate-intensity physical training had lower levels of lipid peroxidation during the second research period. This somewhat favorable change was accompanied by a greater post-workout decrease in FRAP and TP concentrations in blood during the testing second research period compared to the test group. This smaller decrease in FRAP concentrations in the subjects of the study group, despite an approximately 4-fold decrease in blood TBARS concentrations, can be explained not only by its reduced de novo synthesis or increased hepatic utilization, but also by a change in the concentration of inhibitors that modify the reaction rate of the described biochemical reaction.In their study, Schröder et al. attempt to explain the mechanism of the change in the concentration of oxidative stress markers under the influence of exercise. They explain this fact by activating an additional pool of antioxidants in the body which act protectively on cell membranes [It can be said that despite the increase in oxygen in the respiratory air in the study group during physical training, the therapeutic process did not lead to oxidative stress. It should be remembered that the aerobic mitochondrial metabolism on the respiratory chain is a source of a huge number of free radicals.Physical exertion causes, in all individuals, a significant increase in oxygen consumption, exceeding up to 200 times that at the rest. Under these conditions, ROS production increases. An increase in markers depicting increased lipid peroxidation has been noted in obese patients after submaximal exercise [Our study shows that breathing an oxygen-enriched air mixture at a flow rate of 6 L/min during exercise results in less acidification of the body compared to the metabolic response of the subjects to exercise of the same load and breathing atmospheric air [