Statistical analysis
tumor, CRC
TUMOR
Multiple imputation was conducted to fill the missing data of the included variables [The 1-, 3-, and 5-year OS and DFS were calculated using the Kaplan–Meier method, and the survival differences of CRC patients between low and high levels of serum liver enzymes were compared using log-rank tests. The prognostic values of clinicopathological features and preoperative serum liver enzyme markers were estimated using univariate and multivariate Cox proportional hazards models, and the results were presented as hazard ratio (HR) and 95% confidence interval (CI). Subgroup analyses were also conducted stratified by age, gender, tumor location, tumor diameter, CEA, and CA19-9.The nomograms that combined significant serum liver enzyme markers and clinicopathological features were developed, to predict the probability of 1-, 3- and 5-year survival recurrence/metastasis of patients with stage II/III CRC in the training and testing sets. The variables with a The prediction accuracy of nomograms was evaluated by the concordance index (C-index) [All the statistical analyses were conducted with SPSS 24.0 (SPSS Inc., Chicago, IL, USA) and R 4.1.2 software (Institute for Statistics and Mathematics, Vienna, Austria). Two-sided 