Statistical Analysis
REGRESSION
Differences in demographic and clinical characteristics between EDIC participants and controls were tested using the Wilcoxon rank-sum test for quantitative characteristics or the χSeparately for EDIC participants and controls, linear regression models were used to evaluate the individual associations of each MRI measure (independent variable) with a summary z-score for each cognitive domain, adjusting for age, sex, years of education, and scanner. Finally, similar linear regression models were used to evaluate differences in brain ROIs between groups as well as to assess associations between risk factors and ROIs among only EDIC participants. Results with false discovery rate (FDR) values less than 0.05 were considered significant. All analyses were performed using SAS software version 9.4 (SAS Institute). Data analyses were performed between July 2020 and April 2022.