Methods
death
REGRESSION
This randomized clinical trial was preregistered at ClinicalTrials.gov (Clinicians were included if they had prescribed an opioid within the 12 months before a patient’s death from July 1, 2015, to June 30, 2016. We analyzed 12 months of data before and after the intervention. We evaluated the change in total weekly MMEs dispensed using a mixed-effects regression with interactions between conditions, at 1 to 3 months and 4 to 12 months after the intervention. The model was left-censored to account for weeks with no prescribing. We used logistic regression to analyze new starts on opioids and high-dose prescriptions of at least 50 and 90 MME. We report model-adjusted 5% trimmed means and bootstrapped 95% CIs.