Reproducibility of TBK measurements with the 
At baseline, TBK was measured on two consecutive days in each patient. The mean difference between these measurements was 0.024 g/kg body weight (-0.20; 0.07), P = 0.26. Intraclass correlation: 0.93, P<0.001. A Bland-Altman plot is shown in S2 Fig in S1 File.