Relationship of cytokines and PFT parameters for ACS group.
REGRESSION, ASTHMA, ASTHMA
Linear regression model for the association between changes of FVC, FEV1, FVC, TLC and changes of inflammatory markers with treatment as covariates for the ACS group.e.g., change of FVC = b0 + b1*trt + b2*change of log10(TNFa) + error. The table shows the estimates of b2 for different PFT parameter outcomes and different biomarkers.To investigate the association of ACS and lung function, multivariable GEE modeling with natural link and working independence correlation structure was used along with investigation of other confounding predictors, including, age, sex, asthma, hydroxyurea, and treatment arms. Age was significantly associated FEV1 (-0.881, 95%CI: (-1.75, -0.014), p = 0.047) and FEV1/FVC (-0.611, 95%CI: (-1.043, -0.179), p = 0.006). Compared to females, males had significantly lower FEV1/FVC (-3.42, 95%CI: (-6.60, -0.24), p = 0.035) and higher TLC (8.54, 95%CI: (0.758, 16.3), p = 0.031). Asthma status was significantly associated with FEV1 (-8.98, 95%CI: (-16.38, -1.58), p = 0.017) and FVC (-8.850, 95%CI: (-16.4, -1.25), p = 0.022); history of ACS was significantly associated with TLC (-10.9, 95%CI: (-20.5, -1.24), p = 0.027); and treatment arm was significantly associated with FVC (-6.879, 95%CI: (-13.49, -0.272), p = 0.041) (