Randomization and masking
Patients were assigned to two groups via a computer-generated randomization schedule. The ADSCs Group was injected with ADSCs while Placebo Group was received 0.9% saline solution administration. Concealed allocated codes were kept in signed and sealed envelopes. An external investigator performed the randomization. Investigators, patients and investigators were masked to group assignment. Blinding was revealed after the treatments were performed and the data were analysed.