Author contributions
MH
RECRUITMENT
VTS, YT, and KIG conceived of the presented idea and designed the study. VTS and SB conceived of the patients recruitment. VTS, PK, KT, GT, DM, and EP contributed to sample collection, sample preparation, and data analysis. VTS, GDV, ET, MH, and KA contributed equally to the writing the paper. ZD, YT, and KIG supervised the study. All authors have read and agreed to the published version of the manuscript.The authors appreciate the friendly cooperation of patients.