 In-Vivo experiments
Among the 34 patients admitted to our hospital from June 1st, 2021 to April 1st, 2022, 32 patients who matched the inclusion and exclusion criteria were enrolled (Fig. 1). Sixteen patients were randomized to the laser and freehand groups each. Thirty patients completed the study period. Two patients were lost at postoperative follow-up (one patient in each group was excluded). Table 
General characteristics of patients. Categorical data were compared using χ2 tests or Fisher’s exact test. There was no statistically significant difference in two groupThe first success rate was 93.3% (14/15) in the laser group and 60% (9/15) in the freehand group; the difference was statistically significant (χ2 = 4.658, 
In-vivo Experiments Section data. Continuous variables with non-normal variables were reported as median (Lower Quartile; Upper Quartile)，and categorical data were analyzed using Fisher’s exact test or χ2 tests