Results
HF1400, 127,897
From January 1st, 2021 until December 31st, 2021, 765 daily measurements of calcium excretion in CVVH ultrafiltrate in 84 patients were analyzed for this study. Characteristics of patients and the CVVH episodes are shown in Table Characteristics of analyzed CVVH episodes (days) and patients used for developing the model to calculate calcium loss by CVVH ultrafiltrate (development) and for validation of the modelIn the development set, using a mixed linear model, we found a linear association between daily calcium excretion in the ultrafiltrate (dependent variable) and the product of plasma calcium and ultrafiltration flow ([Ca]Adding the potential covariates, i.e., citrate dose, ratio of pre-dilution to post-dilution, and used filter (HF1400 or ST150), did not improve the fit of the model (Supplementary Table 1).Figure Bland–Altman plot showing the association between the difference between calculated calcium excretion and measured calcium excretion in ultrafiltrate (From January 1st, 2014 until July 1st, 2021, 788 patients were treated with CVVH and citrate anticoagulation (Table Characteristics of patients (During the study period, 129,752 CVVH episodes (days) were analyzed, 127,897 with the HF1400 filter and 1855 with the ST150 filter. Substitution fluid was Biphozyl (Calculated calcium excretion by CVVH was 105.8 ± 19.3 mmol/24 h. Calcium administration by substitution fluid and by intravenous infusion was 92.9 ± 23.9 mmol/24 h. The CVVH calcium balance was − 12.0 ± 20.0 mmol/24 h.The mean number of CVVH days per patient was 6.7 ± 9.4 days. Cumulative CVVH calcium balance was − 86.3 ± 251.4 mmol (range − 3687 to 448 mmol). Cumulative CVVH calcium balance by time on CVVH is shown in Fig. Cumulative CVVH calcium-balance by time on CVVH (hours) in 788 patients treated with CVVH in the ICU. Calcium-balance = calcium supplementation by CVVH substitution fluid + intravenous calcium administration – calcium loss in ultrafiltrate. Calcium loss (mmol/24 h) calculated as − 1.279 + 0.646 * [Ca]In a population of patients admitted from 2014 to 2020, all treated using a protocol with calcium supplementation aiming at a target plasma ionized calcium greater than 0.9 mmol/l, the calculated daily mean calcium excretion by CVVH was higher with increasing plasma ionized calcium concentrations (data not shown). The mean daily CVVH calcium balance in subgroups by blood ionized calcium concentrations is shown in Fig. Mean and SD of daily CVVH calcium balance by plasma concentration of ionized calcium in patients admitted to the ICU from January 1st, 2014 until December 31st, 2020 with target [CaIn patients with a [CaThe mean [Ca]