3.4. Cognition
MINOR
Six cognition tests were conducted at baseline and after 12 weeks of intervention. For two of these tests, all subjects scored high already at baseline and only minor changes over time were observed (Four Choice Reaction time and Computerised Corsi block; results not presented). For the other four tests, differences between the groups were measured (A significant effect of LPHEAL9 on short-term memory was observed in the word recall test (Working and spatial memory were tested using the numeric working memory test (NMW). Intake of LPHEAL9 reduced the reaction time from baseline to week 12 compared to intake of placebo (Attention and vigilance were studied using the rapid visual information processing test (RVIP), where the subjects had to indicate when three odd or even numbers appeared in a row from the numbers appearing in quick succession on the screen. Also, in this test, intake of LPHEAL9 was seen to cause a greater reduction in reaction time compared to placebo (In the paired associate learning test (PAL), the total and mean errors to success were evaluated. Following 12 weeks of LPHEAL9 treatment, the total errors decreased significantly compared to baseline for both the ITT (