Metformin prevented bed rest‐induced myofiber atrophy in a fiber‐type‐dependent manner and reduced hybrid fibers
A representative image used for myosin heavy chain (MyHC) cross‐sectional area (CSA) and fiber typing analyses can be found in Figure Metformin prevented myofiber cross‐sectional area reduction after bed rest. (a) Representative image used to determine myofiber type specific CSA. (b, c) Frequency distribution of myosin heavy chain I (MyHC I) PRE and POST. (d) POST delta (Δ) from PRE‐intervention percent fiber frequency of MyHC I myofiber cross‐sectional area (CSA) from 250 to 10,000 μmMyHC fiber distribution displayed MyHC I as the most abundant (Figure 