Role of the risk score in 
REGRESSION, EVENTS
In the training set, logistic regression analyses showed a significant positive association between the Met cycle‐related risk score and the risk of MMD in Crude model (OR = 5.904, 95%CI = 3.153–11.057, Association between Met cycle‐related risk score and risk of MMD and its subtypes in the training set.
ROC curves of Met cycle‐related risk score in different models for the risk of MMD and its subtypes in training set. (A–C) ROC curves of Met cycle‐related risk score in different models for the risk of MMD and its subtypes. A. MMD overall; B. Ischemic‐type; C. Hemorrhagic‐type. (D–F) ROC curves of low and high levels of Met cycle‐related risk score in different models for the risk of MMD and its subtypes. D. MMD overall; E. Ischemic‐type; F. Hemorrhagic‐type. (G–I) ROC curves of Met cycle‐related risk score tertiles in different models for the risk of MMD and its subtypes. G. MMD overall; H. Ischemic‐type; I. Hemorrhagic‐type.We then compared the risk of MMD between individuals with low and high‐risk scores and found that the high risk score was significantly associated with the higher risk of MMD in Crude model (OR = 23.185, 95%CI = 6.859–78.363, We further classified the risk score into three levels based on the tertiles and analyzed the correlation between risk levels and MMD. As the risk level enhanced, the proportion of MMD events significantly increased (Table We calculated the Met cycle‐related risk score of the individuals in the testing set and verified the association between the risk score and MMD. Subsequently, the participants in the testing set were then stratified into different risk levels based on the median value and tertiles of the risk score. The results confirmed that the risk score was independently associated with MMD and its subtypes (Table Association between Met cycle‐related risk score and risk of MMD and its subtypes in the testing set.
ROC curves of Met cycle‐related risk score in different models for the risk of MMD and its subtypes in testing set. (A–C) ROC curves of Met cycle‐related risk score in different models for the risk of MMD and its subtypes. A. MMD overall; B. Ischemic‐type; C. Hemorrhagic‐type. (D–F) ROC curves of low and high levels of Met cycle‐related risk score in different models for the risk of MMD and its subtypes. D. MMD overall; E. Ischemic‐type; F. Hemorrhagic‐type. (G–I) ROC curves of Met cycle‐related risk score tertiles in different models for the risk of MMD and its subtypes. G. MMD overall; H. Ischemic‐type; I. Hemorrhagic‐type.