Strengths
SECONDARY
Our methods have several important strengths. First, the trial has been designed as a pragmatic trial to ensure that if shown to be beneficial, the intervention could be translated into routine clinical care.Second, we designed the intervention as scalable so that it could be easily rolled out to routine clinical practice without incurring prohibitive costs or placing an additional burden on the medical staff in order to facilitate trial translatability.Third, the conclusions will be principally based on the results of the primary outcome. For secondary outcomes, we will present two-sided 95% confidence intervals but not report Fourth, the primary outcome, the distance walked during the 6MWT, is a patient-centered outcome closely associated with patients’ functional status. Additionally, the 6MWT is commonly used in the management of HFrEF patients, making it relatively simple for clinicians to interpret.Finally, the intention-to-treat principle of the primary analysis will provide an unbiased estimate of the intervention’s effectiveness, maintain the randomization of study groups, prevent potential biases from selective exclusion, and provide a conservative estimate of the intervention effect.