Effect of distal motor function preservation at enrollment
A post hoc analysis was performed to characterize the effect of level of preservation of distal motor function at enrollment on treatment-related changes in impairment and function. Preservation was defined as the presence, at screening, of active extension of the wrist and two digits plus active thumb abduction/extension, repeatable three times over a 1-min period, similar to what was applied successfully in the EXCITE and more recent VNS trials