Acknowledgements
We thank the patients who took part in the SYNAPSE study. Editorial support (in the form of writing assistance, including preparation of the draft manuscript under the direction and guidance of the authors, collating, and incorporating authors’ comments for each draft, assembling tables and figures, grammatical editing and referencing) was provided by Rachael Baylie PhD, of Fishawack Indicia Ltd, UK, part of Fishawack Health, and funded by GSK.The authors would like to thank the principal investigators and patients of the SYNAPSE study. Participating SYNAPSE investigators: 