Introduction
Ca-Ph-parathormone abnormalities, neuropathic pain, xerosis, ESRD, pruritus, Uremic pruritus
END STAGE RENAL DISEASE, ESRD, XEROSIS
Uremic pruritus (UP) is considered one of the most prevalent and annoying symptoms in end stage renal disease (ESRD) patients [Many therapeutic interventions have been studied to improve UP with variable degrees of success including emollients (improve xerosis), optimizing dialysis (remove uremic toxins), correcting Ca-Ph-parathormone abnormalities, gabapentin and pregabalin (modulating neuropathic pain), montelukast (leukotriene inhibition), naltrexone and nalfurafine (targeting µ and κ receptors), mirtazapine (antagonist of 5HT2 and 5HT3 receptors), difelikefalin (agonist of the κ-opioid receptor) and phototherapy [Selective serotonin reuptake inhibitors (SSRIs) have been shown to lower the severity of pruritus [