What do these findings mean?
non-syndromic familial CRC
The findings of this trial indicate that FIT does not have the capacity of increasing the acceptance of screening in the non-syndromic familial CRC population.The fact that over 50% of eligible individuals refused to participate indicates that novel educational measures should be implemented to improve the awareness of individuals at risk and their providers.Future studies are needed to assess whether screening uptake can be improved for these individuals through their inclusion in population-based screening programs or by offering a choice between FIT and colonoscopy screening. The main limitation of this study was that it was not possible to collect information on eligible individuals who declined to participate, thus impeding our understanding behind low screening uptake in this population.