Introduction
Gastric cancer, death
GASTRIC CANCER, DISEASE
Gastric cancer (GC) is the third most common cause of cancer-related death worldwide [In the third- or later-line setting, trifluridine and tipiracil (FTD/TPI; TAS-102), comprising trifluridine, a thymidine analog, and tipiracil, a thymidine phosphorylase inhibitor [As response to systemic therapy varies from individual to individual, it is important to identify patients who will benefit most from second- or third-line chemotherapy. In this context, understanding prognostic factors for survival and quality of life may help clinicians optimize and individualize treatment, hopefully providing an opportunity to intervene and change the course of the disease [Here, we report results from a retrospective, post hoc analysis of the phase III TAGS trial, in which we examined the association of early BWL with survival outcomes and safety in patients with mGC/GEJC treated with FTD/TPI or placebo in the third- or later-line setting.