Author contributions
Z.-M.S., Z.-H.W., and Y.-Z.J. conceived and designed the study. Z.-M.S., Z.-H.W., and Y.-Z.J. supervised the study. Y.L., T.S., J.-W.C., Z.L., H.-P.L., and Z.-H.W. carried out the clinical trial. Y.L., X.-Z.Z. and Q.Y. acquired the data. Y.L., X.-Z.Z. did the statistical analysis. Y.L. and X.-Z.Z. analyzed and interpreted the data. Y.L., X.-Z.Z., S.-Y.W., Y.X., W.-J.Z., and Y.-Z.J. drafted the manuscript. All authors critically revised the manuscript. J.-J.L., A.-Y.C., K.-D.Y., G.-Y.L., J.W., T.S., J.-W.C., Z.L., H.-P.L., Z.-M.S., Z.-H.W., and Y.-Z.J. provided resources. Z.-M.S., Z.-H.W., Y.-Z.J., Y.L. and X.-Y.Z. obtained funding. Z.-M.S., Z.-H.W., and Y.-Z.J. have accessed and verified the data.