Author contributions
SP and FlM contributed equally to the writing of the entire protocol. A-LP, CV and FrM brought a global expertise in methodology and particularly contributed to the drafting of the parts entitled Randmisation, Statistical justification of the number of patients to be included and Data analysis. BC, FlM, NT and YS Junior brought their expertise in the field of adapted physical activity and particularly contributed to the writing of the sections Adapted Physical Activity Program and Outcomes. AL, ET and CB-S brought their medical expertise and particularly contributed to the Introduction, Discussion and Outcomes sections. SP, DB and ET brought their expertise in clinical research and contributed to the drafting of the protocol in its entirety. All authors contributed to the article and approved the submitted version.