Dose–response for grade 4 decreases in absolute neutrophil count in Cycle 1.
REGRESSION
Based on ANC laboratory data. Figure shows the percentage grade 4 ANC decreases per cohort in Cycle 1 (coloured dots) versus planned total Cycle 1 dose. A grade 4 ANC decrease was defined as an ANC < 500 cells/μL post-baseline. The size of the coloured dots represents the relative cohort size. The black dashed line and grey shaded area represent the best fit of the data and 95% confidence interval based on simple logistic regression, respectively. Patients without ANC observations in Cycle 1 were excluded. ANC absolute neutrophil count, G-CSF granulocyte colony-stimulating factor.