Procedures and follow-up
HFSR
ADVERSE EFFECTS, SKIN LESIONS
Follow-up was conducted every week during the first cycle, then every two weeks thereafter for a total of 12 weeks or until treatment discontinuation. The majority of routine, follow-up appointments included a physical examination, laboratory tests (including serum CA19-9 and carcinoembryonic antigen levels), chest radiography, and computed tomography. Dermatological examinations included an assessment of the HFSR symptoms, adverse effects of aluminum chloride ointment, and the presence of other skin lesions. In addition, the palms and soles were photographed every one to two weeks by three dermatologists using a digital camera. HFSR grading was performed in a central review using clinical photographs. If disagreement occurred, the final assessment was decided by the majority (two persons); if all three persons disagreed, a discussion was held until a consensus was reached.