Study design
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MULTIPLE SCLEROSIS
A double-blind (allocation concealment was performed by a blinded investigator and by blinding for assessors) randomized controlled trial (RCT) (NCT04171908, clinicaltrials.gov) was conducted. Consolidated Standards of Reporting Trials (CONSORT) statement was consulted to help authors improve the reporting of the RCT. A non-probabilistic sampling of consecutive cases was performed. The sample was randomised into two study groups: the EG and the control group (CG), using the QuickCalcs GraphPad® software by a computer-generated sequence. The allocation was performed by a blinded investigator. The EG received a conventional physical therapy program along with the application of a VR protocol and specifically designed video games for UL treatment in individuals with MS. The CG received only the conventional therapy program. All interventions were carried out at the Leganés Association of Multiple Sclerosis (ALEM) in Madrid, Spain.This protocol was approved by the Ethics and Research Committee of Rey Juan Carlos University with reference number 2310202119821. Written permission was obtained from all selected individuals through the informed consent form.