Effects of Laparoscopic Gastrectomy on Clinical Outcomes Compared With Open Gastrectomy
tumor, cardiac complications, Comorbidity
TUMOR, CARDIAC COMPLICATIONS
Besides a significantly reduced risk of an in-hospital stay above the median of 7 days [adjusted odds ratio (aOR): 0.56; 95% CI: 0.31–0.99], no significant effect of laparoscopic gastrectomy on postoperative clinical outcomes was observed within the LOGICA RCT (Table Multivariate Comparison of Clinical and Pathologic Outcomes of Laparoscopic Versus Open Gastrectomy in the LOGICA and DUCA Data SetsBold values are statistically significant.n (%); median (IQR).Adjusted odds ratio. Corrected for: sex, age, BMI, Charlson Comorbidity Index, ASA-score, tumor location, cT stage, cN stage, cM stage, neoadjuvant therapy, type of gastrectomy, and year of surgery as random effect factor. In case of insufficient degrees of freedom for correction for the entire correction model, only confounders leading to a 10% change in odds ratio were included in the multivariable model. Year of surgery was added as random effect factor to the model in case the log-likelihood ratio test showed a better fit compared with the original multivariable model.Neoadjuvant therapy.Surgical procedure.BMI.Wilcoxon rank sum test.BMI indicates body mass index.Subgroup analyses of matching the DUCA data set to the inclusion and exclusion criteria of the LOGICA RCT showed consistent results with clinical benefits observed with laparoscopic gastrectomy, including significantly less overall and cardiac complications and a lower risk of an in-hospital stay above the median of 8 days (Supplementary Table 1, Supplemental Digital Content 1, 