Findings
ADVERSE EVENTS, GLIOBLASTOMA
In this randomized clinical trial of 88 patients with recurrent glioblastoma, the addition of disulfiram and copper to alkylating chemotherapy did not significantly improve survival at 6 months, as compared with alkylating chemotherapy only. Significantly more patients receiving disulfiram had adverse events of grade 3 or higher (34% vs 11%) and serious adverse events (41% vs 16%).