ACKNOWLEDGMENTS
Funding for this study was provided by GSK. All listed authors meet the criteria for authorship set forth by the International Committee for Medical Journal Editors. Funding for this study was provided by GSK. Editorial support, Meher Dustoor, PhD and Sarah Hummasti, PhD (assembling tables and figures, collating author comments, copyediting, fact checking, and referencing), and graphic services were provided by AOIC, LLC, and were funded by GSK. The authors thank Clive Felgate and Swetaben Patel for the preparation of duodenal bile extracts for metabolite profiling by AMS and for helping with profiling experiments in multiple matrices including plasma, urine, and feces.