Materials and methods
RECRUITMENT
We conducted this randomized controlled clinical, single-centre trial between March and September 2021 at the Hannover Medical School (MHH). No changes to the methods were made after trial start. The local ethical committee approved the study (Nr.: 9579_BO_S_2021), and written informed consent was obtained from all healthy volunteers participating in the study before recruitment. The manuscript follows the CONSORT guidelines for reporting parallel group randomized trials and corresponds to the CONSORT checklist [