Ethical statement
The trial was a single-center, open-label, randomized study at the First Affiliated Hospital of Air Force Medical University (Xi’an, China) and was registered in ClinicalTrials.gov (NCT03206684). The study protocol was following the Guidelines of Helsinki, reviewed and approved by the Ethics Committee of the First Affiliated Hospital, Air Force Medical University (KY20172040-1). All patients provided informed consent to participate.