Trial population
A total of 73 participants with OB were screened. After determining their study eligibility, 66 participants were included in the trial. Those participants were randomly assigned to one of two groups: 32 received liraglutide 3.0 mg combined with lifestyle counseling and 34 received a placebo combined with lifestyle counseling (see Fig. Summary results of BOLD activations for the liking main effect.Thresholding We ran a sensitivity analysis on the equivalent ANOVA model to the linear mixed model we report below, testing the 2 taste stimuli × 2 interventions × 2 pre–post effects on the liking ratings. This analysis revealed that this sample size allowed for the detection of a smallest population effect size of 0.177 (Cohen’s 