Comparison of HA to LA
We identified differentially expressed sequences with altitude in the PBMCs using two approaches (of note, we use the term ‘sequence’ because we mapped subject transcriptomes against the Reference Sequence (RefSeq) database, which contains both genes and non-coding transcript sequences such as long non-coding RNAs-lncRNAs). In the first approach, the 14 HA samples were compared with the 14 LA samples, independent of control or DEX-p group, using the algorithm DESeq2 [