Objective
non-alcoholic fatty liver disease, NAFLD, TCM
METABOLIC DISEASE, NON-ALCOHOLIC FATTY LIVER DISEASE
Edited by: Xinhua Shu, Glasgow Caledonian University, United KingdomReviewed by: Tianhao Liu, Affiliated Hospital of Jiangnan University, China; Kangxiao Guo, Central South University Forestry and Technology, China; Haoqing Shao, Hunan University of Medicine, China†These authors have contributed equally to this workThis article was submitted to Gut Endocrinology, a section of the journal Frontiers in EndocrinologyAs a metabolic disease, one important feature of non-alcoholic fatty liver disease (NAFLD) is the disturbance of the intestinal flora. Spleen-strengthening and liver-draining formula (SLF) is a formula formed according to the theory of “One Qi Circulation” (Qing Dynasty, 1749) of Traditional Chinese Medicine (TCM), which has shown significant therapeutic effect in patients with NAFLD in a preliminary clinical observation. In this study, we aim to explore the mechanism of SLF against NAFLD, especially its effect on glucolipid metabolism, from the perspective of intestinal flora.