Response Assessments
DISEASE PROGRESSION, DISEASE
Magnetic resonance imaging with and without gadolinium enhancement was performed within 2 weeks before the start of protocol therapy. In case of surgery, postoperative MRI was required within 72 hours after surgery. Six months after the start of antiangiogenic treatment, MRI was mandatory to assess response. A CSF cytologic test was performed once at each cycle of intraventricular therapy. Continuing response or stable disease was confirmed every 3 months until disease progression or study discontinuation. The MRIs were collated and centrally reviewed by an experienced panel of pediatric neuroradiologists and pediatric neurooncologists (A.P. and M.S.).