Criteria for discontinuing or modifying allocated interventions
ADVERSE EFFECTS
In the intervention clusters, nurses and/or peer navigators will engage participants throughout the trial, and tailor their HIV prevention to their risk, including stopping and starting PrEP. Participants who experience adverse effects will be referred to a fixed PHC for care if necessary. If anyone seroconverts on PrEP (new positive ELISA test), we will support them to start ART immediately, check for HIV resistance, and switch to monitoring HIV viral loads. In the control clusters, care will be provided by the department of health nurses in PHCs according to the current South African National guidelines. All study participants will continue to receive ART/PrEP and contraception through the PHCs after the trial end.