Explanation for the choice of comparators {6b}
According to the TwiCs design, the control group will receive standard of care. Current standard of care is surgical stabilization with or without decompression followed by radiotherapy (either cRT or SBRT) as soon as the wound is healed sufficiently, which is usually after a minimum time interval of 1 week. Inherent to the TwiCs design, control patients will not be informed about the trial and that they serve as a control. Previous research showed that most patients were positively or neutrally to having served as controls without notification of being selected for the control group [