MRI processing
T1-weighted images were processed using the FSLanat pipeline (All ASL images were registered to their corresponding T1 scan and then registered to MNI space using T1 to the MNI registration matrix. For each participant, the 16-week ASL maps in MNI space were then subtracted from the corresponding baseline ASL map in MNI space to calculate the change in ASL parameters in each voxel during the exercise intervention period.