Limitations
HED
Our findings must be interpreted in the context of the limitations of the study. First, the sample size was based on a previous study including up to five aerobic exercise sessions per week. Thus, the lack of differences between MED and HED or DCON and MED could be a type 2 error due to low statistical power. However, given the consistent signal across most beta-cell indices, the results can be interpreted with confidence. Second, we assessed beta-cell DI with a hyperglycemic clamp. Although the hyperglycemic clamp is the gold standard for beta-cell function