Discussion
cough
PATHOGENESIS
This article describes an exploratory study protocol to investigate the efficacy of duloxetine in patients with refractory cough through a randomized, double-blinded, placebo-controlled clinical trial. Based on the known pathogenesis of refractory cough and the pharmacological mechanism of duloxetine, we hypothesize that duloxetine will relieve the symptoms of refractory cough patients and may further improve their psychological problems, proving itself beneficial to refractory cough patients.