Author contributions
Study concept and design were contributed by AC, RP, GB. Acquisitions of data were contributed by G.Ferrara. Data analysis, figures and statistics were contributed by AC, RP, GB, FS. Drafting of the manuscript was contributed by AC, FS, IS, GB, RP, LM, KM. Critical revision of the manuscript was contributed by G.Fusco, GC, PS. All authors read and approved the final manuscript.