Discussion
tubal infertility, premature death, chronic pelvic pain, MSM
ENDOMETRIOSIS, PELVIC INFLAMMATORY DISEASE, PREMATURE DELIVERY, STIS, ECTOPIC PREGNANCY, COMPLICATIONS
The trial enrolled 449 young women, who were taking HIV PrEP, and half (224) were randomly assigned to take doxycycline PEP. The use of doxycycline as PEP or PrEP for STI prophylaxis is concurrently being evaluated in multiple ongoing trials in the US and Australia among MSM [Social structures and sexual behaviour that necessitate HIV PrEP use often correlate with a high risk of being exposed to a bacterial STI [A total of 180 (40.1%) of the cohort identified their sexual behaviours as possibly increasing the risk of STIs with more reporting concerns with the behaviours of their male partners (45.9%, 206 women). Overall, slightly less than half of the women, 200 (44.5%) were concerned about contracting STIs in general. This cohort reported low rates of condom use and fear of conflict with negotiated condom use, highlighting the need for structural interventions beyond individual behaviour to reduce the risk of STIs among women [Health complications that may stem from STIs among cisgender women include tubal infertility, chronic pelvic pain, pelvic inflammatory disease, ectopic pregnancy, post-partum endometriosis, adverse neonatal outcomes like premature death and premature delivery, and increased risk of HIV acquisition[Women of reproductive age in middle and low-income countries are at increased risk of STI-related complications due to limited access to effective prevention strategies, diagnostic testing, or timely treatment [