Main
T1D, enteroviral infection, Diabetes
ENTEROVIRAL INFECTION, AUTOIMMUNE RESPONSE, ENTEROVIRUS, DISEASE, TYPE 1 DIABETES, DIABETES
Type 1 diabetes (T1D) is characterized by progressive loss of pancreatic β cell function that leads to lifelong dependence on insulin therapyThe disease is the result of a complex interplay between genetic predisposition, the immune system and environmental factorsIn the Diabetes Virus Detection study (DiViD), pancreatic tissue was collected from six adult patients with newly diagnosed T1DPleconaril, developed against enteroviruses, clears viruses in β cell models of persistent enterovirus infectionDespite existing evidence for enteroviral infection initiating the autoimmune response and subsequent β cell destruction in genetically predisposed individuals, it is unclear if the main effect of the viruses is to initiate or drive the disease process, or both