Medication effect on cumulative work for alcohol over experimental time.
SECONDARY
Medication effect (difference between treatment and baseline) on cumulative work for alcohol over experimental time. Shaded areas = SEM. Note: 0–75 min = ascending phase of BrAC; 75–150 min = plateau phase of BrAC.Treatment-induced changes of the secondary outcome variables cWFS, peak BrAC, or mean BrAC did not differ between groups, neither during the ascending nor the plateau phase.Analyses of the correlations between naltrexone blood levels and treatment effects for both phases were performed in the ITT sample in order to include the two participants with zero blood levels. Higher naltrexone blood levels were associated with a more pronounced decrease in cWFA (