DISCUSSION
aggression, intellectual disabilities
ADVERSE REACTIONS, SECONDARY
In this pragmatic RCT involving people with intellectual disabilities and borderline intellectual functioning, we found no significant difference in the number of aggressive incidents between those assigned to dietary supplements and those assigned to placebo: neither in the total score, nor in the scores broken down by type of aggression. We neither found a significant difference in effectiveness on secondary or safety outcomes. Finally, we found no difference in the total number of adverse reactions reported between the two groups. It should be noted, however, that the number of registered incidents had doubled during the COVID‐19, and we found a trend that the direction of the effect changed during the pandemic, which may have affected our effect estimates.In the past decades, 11 RCTs have been performed with multivitamin‐mineral supplements as an intervention and aggressive behaviour as an outcome (De Bles et al., 