Randomization and Blinding
Upon inpatient admission orders being placed by the treating clinicians, eligible patients were randomized by an Epic BestPractice Advisory that ran in the background and was not seen by clinicians. The advisory programmatically generated a random binary value to determine whether the patient was assigned to the control group or intervention group. The group to which each patient was assigned was saved for that admission encounter and then extracted into a daily report.The study principal investigator and the pediatric hematologists (S.C.W. and A.P.W.) who reviewed patients with elevated risk were unblinded to the intervention. Assignment to the intervention or control group was concealed for all other study personnel. Group assignments remained concealed from the biostatistics team and safety monitoring committee until primary data analysis was complete. The principal investigator was not responsible for diagnosing HA-VTE.