2.4. Randomization and blinding
First, after signed the concealed allocation protocol, the subjects were randomly divided into 2 groups to receive different non-pharmacological treatments. We adopted simple randomization and used the number table grouping method for grouping: group A for CST and group B for CLST. Instead, they were told that 2 different CST techniques would be tested. After 4 weeks, group A and group B were swapped. Second, throughout the study period, the investigator assessing the outcome remained unaware of the allocation of subjects. Third, the statistician who analyzed the results was also blinded to the group assignment.