Study setting and Ethics
diabetic
Between June 2018 and September 2019, this prospective, controlled, one-blind, randomized clinical trial enrolled 180 diabetic subjects who were outpatients at the Clinic of Periodontology of the Faculty of Dental Medicine of Albanian University. All participants provided informed written consent prior to patient enrolment and randomization. The study protocol was approved by the Institutional Review Board at Albanian University (reference number 2018/224) and was performed in compliance with good clinical practice and followed the ethical standards established in the Declaration of Helsinki. The study was registered with ISRCTN17281691. Patients consenting to participate in the study were randomly assigned to one of two treatment groups. The study design followed the CONSORT guidelines [
Participant flow diagram