Authors Contribution
MRC and HLL have contributed equally to this work. MRC, HLL, and SY are responsible for the conception of the trial. HP, LCS, CHL, XSC, WL, JH, JH and YX were involved in the design of the trial. NZZ, YQC, TH, DNZ, YYS, LZ and XML were involved in the acquisition and analysis of data for the trial. MRC and HLL were involved in drafting the manuscript. LC, MRC, and YX were involved in revising the manuscript. All authors have agreed the final version of manuscript.