1. Introduction
Caffeine is an adenosine ATraining, nutrition, motivation, and genetics (talent) are key factors in achieving high levels of athletic performance [Adenosine is one of the metabolites produced by dephosphorylation of the Adenosine Triphosphate (ATP) via 5-nucleotidease enzyme during the exercise [Research suggests that caffeine can block adenosine receptors, which may induce increased neurotransmitter dopamine release [Adenosine AThere seems to be inter-individual differences in response to caffeine intake among people [There is no study investigating the effect of the In addition to MPO, the hydrolytic acetylcholinesterase (AchE) enzyme is considered as an inflammatory marker [It has been shown that caffeine has anti-inflammatory effects and is able to significantly reduce the activity of MPO and AchE during exercise activity [Therefore, the aim of the present study was twofold: (1) to investigate the association of the 