Comparison to interatrial shunt devices
Heart Failure, RV deterioration
HEART FAILURE
Interatrial shunt devices were a large spark of hope for a high number of patients with HF. Promising early results of the REDUCe Elevated Left Atrial Pressure in Patients with Heart Failure (REDUCE LAP-HF), with regards to symptoms and hemodynamics have been reported and have led to the initiation and completion of the REDUCE LAP-HF II trial, which failed to show statistical significance for its primary endpoint [First of all, the theoretical concept of an iASD device is reducing left atrial pressure by decongesting the left atrium as flow is produced from the left atrium to the right atrium. This in line, increases the right atrial pressure and might cause RV deterioration. An iASD diameter of 8 mm was identified as the optimal trade-off in theoretical models [