Recruitment {15}
It is intended to include 124 patients at approximately 10–15 sites in Germany within 24 months which is less than 1 patient per month per site. There is no limit to the number of subjects randomized at any individual clinical site. AKI-HRS typically requires hospitalization for its management. These patients are typically hospitalized in hepatology wards or intensive care units. Therefore, only in-patients will be considered for inclusion. All patients fulfilling the inclusion and not fulfilling the exclusion criteria will be considered for the study. Educational measures will be taken to increase awareness in referral hospitals. It is estimated that 2 years will be required to include the patients.