Treatment Outcome
REGRESSION, MAY, INFLUENZA
To assess the treatment outcome, we used logistic regression models to evaluate the weekly odds of the primary outcome for the high-dose compared with standard-dose vaccine treatment group adjusting for state to account for possible regional differences. In a sensitivity analysis, we analyzed the association between ILI activity and outcomes (1) only during months with typically higher influenza activity (September 15th to May 15th of each enrolling season) and (2) during weeks with higher ILI activity (>2 SDs above a state’s mean ILI activity). Last, we compared weekly ILI with outcomes adjusting for state, vaccine treatment assignment, and month, referenced to the month of July.Analyses were performed using Stata, version 14 (StataCorp LLC), and statistical significance was set at 2-sided 