Statistical analysis
REGRESSION
The differences in the study variables between the start (baseline) and end of the study (6-months post-baseline) were evaluated in the per-protocol set. The Between-group differences in the 6-month changes in DAI-10, PHQ-9, and EQ-5D-5 L and PCMCD scores were compared using the unpaired t-test. To examine the factors that influence the DAI-10 scores and their strengthes, a multiple regression analysis was performed with the change in the DAI-10 as the dependent variable.All statistical analyses were performed using the IBM SPSS Statistics Version 26 (IBM Japan, Tokyo).