CONCLUSIONS
The use of a PrEP DST for South African AGYW is a promising strategy to support PrEP use. Web availability of DSTs for remote use or in clinic waiting rooms may facilitate expanded use of DSTs, even in low‐resource settings as mobile and internet coverage in the region expands. The COVID‐19 pandemic has accelerated demand for remote clinical consultations; DSTs, such as MyPrEP, may facilitate HIV prevention service provision outside of clinical settings in the future. As new PrEP methods and multipurpose technologies become available, information about new effective PrEP formulations can be readily incorporated into the MyPrEP DST, potentially facilitating informed decision‐making by AGYW about HIV prevention choices that best meet their needs.