Statistical analysis
tenderness, lumbar pain
REGRESSION, SECONDARY
The primary analysis was the difference risk calculated as the absolute difference with two-sided 95% CI in the proportion of patients reaching the primary and secondary endpoints in patients switched to oral therapy with fosfomycin trometamol and to other drugs. Subgroup analyses (according to sex, age groups, fosfomycin MIC, urinary catheter, and presence of lumbar pain or tenderness) were performed for the primary endpoint. In addition, because patients were not randomized for being stepped-down to oral therapy, a multivariate analysis was performed using logistic regression to estimate the association of oral step-down with fosfomycin with the primary endpoint controlling for exposure variables with a bivariate 