3.5 Population PK/PD analysis of driving confidence
The relationship between THC and driving confidence (DC) was best described by an indirect (delayed) effect compartment model and a sigmoid equation (Eq. 1) with a maximum effect set to 1.In Eq. 1, EC50 represents the concentration leading to 50 % of the maximum effect of DC, E0 the value of DC at time 0, and Ce the concentration in the biophase. The pharmacodynamic parameters, the residual standard error, and the bootstrap are presented in Pharmacodynamic parameters and driving confidence.Ke0, constant transfer to the effect compartment; E0, initial EVA; EC50, THC concentration in the effect compartment with half maximal effect; RSE, residual standard error.