RANKL is significantly decreased after radon spa treatment
To show whether radon or thermal spa treatment leads to a systemic effect that could be the basis of the observed impact on osteoclastogenesis, we investigated bone resorption and bone formation markers in serum or plasma of the patients (RANKL was significantly decreased only after radon spa treatment. No changes in CTX concentration after radon In summary, we observed an effect of radon and thermal spa treatment in the fraction of mOCs and resorbed area on bone slices (