Discussion
postoperative infections, infections
OXIDATIVE STRESS, INFECTIONS, POSTOPERATIVE INFECTION
The use of high postoperative FiOThis findings are in contrast to the results of early randomized trials and the corresponding meta-analyses [Irrespective of the previous studies focused on SSIs, this study provides first data on postoperative hyperoxygenation in LT recipients. Considering the high risk and wide spectrum of postoperative infections in this population, all infections occurring during the 30-day postoperative period were selected as the primary end-point, rather than only SSIs. However, no significant differences between study arms were observed also for particular types of infections, including SSIs, with the actual rates being higher in the 80% FiOHyperoxygenation was reported to aggravate oxidative stress [In addition to the lack of effectiveness with respect to prophylaxis of infections, 80% FiOIn this study, high FiOThe present study is subject to several limitations. First, the planned sample size was not reached due to study termination at the national outbreak of COVID-19 with the actual power of 66.5% for detection of the hypothesized 40% relative risk reduction from 40% to 24% with 80% FiO