Intervention arm
DosePak®, LCD
EVENT
For this trial, we shall use two kinds of MEMS-operated devices, the MEMS cap and the MEMS Electronic DosePak® (EDP). At enrolment, patients on the self-administering arm will be provided with both devices; the MEMS cap will be placed over a medicine bottle containing bedaquiline. The concomitant medication will be packaged in a convenient pack containing all tablets to be swallowed each day and placed into the medication box with the EDP® technology Patients will be instructed on how to use the MEMS devices. Each time a patient opens up the cap over the bedaquiline bottle or the lid of the medicine box, the time and date of this event will be immediately captured. Adherence data from the MEMS devices will be downloaded by the study team every month during the routine visits. The devices will provide information on specific calendar dates and times when the devices were opened. Information on the calendar days with event markings to signify the date and time when medication containers were opened will be displayed on a computer. The software will contain two separate input calendars for both the MEMS cap and the EDP box for each participant. This same adherence data will be shared with primary clinician and used to tailor adherence counselling given to patients, exploring patterns of missed medication and brainstorming for solutions with the patient (Table Description of study armsPatients report daily to the nearest health unit to be observed by a health care provider as they ingest their medicationBehavioural: Adherence counselling. Patients will receive adherence counselling as scheduled by their primary care health providersDevice: MEMS CAP without LCD display and EDP® technology on medicine box.Standard MEMS devices record the time and date when the bottle is openedThe MEMS technology automatically complies drug dosing history information by electronically recording the date and time of each opening of the medication cap and or boxBehavioural: Adherence counselling. Patients will receive adherence counselling as scheduled by their primary care health providers