Author contributions
EGA, CH, EE, MC, BM, CI designed the study. CH, EE, MC, BM, TH, LC, CI, AS, SK developed data collection methods, collected and archived these data. MC, TH, AS and SK analyzed the results. EGA and CH wrote the manuscript with all authors contributing to the final edits. Members of the ICAF Study Group contributed to study design and data collection, and approved the final version of the manuscript.