Author contributions
C.L.
J.C. contributed to study design and coordination. These authors contributed equally to accrual, study conduct and manuscript editing to the current manuscript: J.C., J.H., A.T., C.L., R.G-C., M. Be., A. Cus., A. G.-A., A. Cub., V.A., A.C.-B., T.A.-G., G.C., P.J.-F., M. Bl., A.V., A.L.C., I.S., A.S., M.L., S.L., P.N., and J.L.M.