1. Introduction
rheumatoid arthritis, Rheumatoid arthritis, RA, multiple joints
RHEUMATOID ARTHRITIS, RHEUMATOID ARTHRITIS, DISEASE
The study aimed to elucidate the effective chemical composition and molecular mechanism of rheumatoid arthritis (RA) treatment with Jishe Qushi capsules (JSQS) and perform clinical validation. The effective chemical components were screened by a database. We used Cytoscape software to construct the key target-RA composite target network of JSQS. Gene Ontology biofunctional analysis and Kyoto encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were performed for the key targets, followed by molecular docking validation of core key targets. Ninety-nine patients chosen were divided into 49 cases in the treatment group and 50 cases in the control group according to the random number table method. The control group was treated with the combination of methotrexate (MTX) plus Glucosidorum Tripterygll Totorum. The treatment group was treated with MTX plus JSQS. The treatment effects of the 2 groups were evaluated. A total of 118 key anti-RA targets were obtained for JSQS. Quercetin in Rheumatoid arthritis (RA) is a common immune disease characterized by the symmetrical destruction of multiple joints.Chinese traditional medicine has a curative effect in the treatment of RA. These medicines—such as Glucosidorum Tripterygll Totorum and total glucosides of 