Sample analysis
The plasma and urine concentrations of Acetonitrile (500 µL) was added to the plasma samples (500 µL), vortex-mixed for 10 s and centrifuged at 3,000 × The correlation coefficients of the plasma calibration curves were not less than 0.996 for Urine samples were diluted (1/10–1/40) with purified water. A volume of 50 µL was injected into the chromatographic system. For the urine assay, the mobile phase consisted of NaThe correlation coefficients of the urine calibration curves were not less than 0.998 for 