Function of Col1a1 in regulating healing outcome
To analyze whether the effect of CFD on fibroblast migration act through a pathway involving Col1a1 further experiments were performed. Previous studies have indicated that Col1a1 and its proteolytic-derived peptides at sites of tissue injury may act as chemotactic factors to attract fibroblast migration and initiate repair of damaged tissue (To further support the clinically relevant role of elevated Col1a1 levels at the inflammatory healing stage, the effect of Col1a1 in the proteomic data set from tissue biopsies on clinical healing outcomes was further explored. The results strengthened a potential central function of CFD in tendon repair via inflammation-increased Col1a1 expression by demonstrating that a higher Col1a1 tissue levels improved tendon strength (The effect of Col1a1 on improving 1-year clinical outcomes. Higher Col1a1 expression improved 
