Prediction of antidepressant response
REGRESSION
To examine connectivity-based predictors of response in the active treatment group, whole-brain connectivity of each stimulation site was compared with antidepressant response. For each voxel, a least squares regression model was constructed using baseline target-voxel connectivity and baseline MADRS as predictors of post-treatment MADRS. Because antidepressant response could not be assumed to be normally distributed in this small sample, all data were rank-transformed, which is consistent with prior methods described in Weigand et al.