Ethics approval and consent to participate
We conducted this study in compliance with the ethical standards of the Regional Bioethics Committee of Kaunas, Lithuania (the permission number is BE-2-5) and the World Medical Association Declaration of Helsinki on Ethical Principles for Medical Research Involving Human Subjects. Clinical Trials registration number: NCT05406297, concurrently registered. All subjects gave their informed consent to participate, and an information letter was given to them.