SGM-101 Fluorescent Labeling of CEACAM5-Positive Lung Tumors
adenocarcinoma spectrum lesions, tumor, necrosis
TUMOR, NECROSIS
Five patients with primary nodules were selected for a proof-of-principle study. No elevation in serum CEA levels were found in this patient cohort. The mean (SD) lesion size was 0.68 (0.22) cm. Lack of SGM-101 fluorescence was associated with benign lesions and with lack of CEACAM5 staining. Benign lesions lacked any fluorescence in ex vivo and histologic analyses (The area of fluorescence in patient 8 was lower than the lesion size, but on inspection, the tumor had a significant area of necrosis (>80%); however, the viable areas demonstrated fluorescence with a strong association with areas of TTF-1 and CEACAM5 and a lack of CK 5/6 and p63 staining, indicating adenocarcinoma spectrum lesions. Similarly, CEACAM5 staining was associated with SGM-101 fluorescence emission in this cohort (