Procedure
toxicity, death, cardiac or renal dysfunction
ADVERSE EVENTS, DISEASE PROGRESSION
Patients received iruplinalkib 180 mg orally once daily for a 21-day cycle with a 7-day lead-in phase at 60 mg orally once daily until disease progression, intolerable toxicity, withdrawal of consent, loss of follow-up, start of other antitumor treatment, or death. If grade ≥ 2 cardiac or renal dysfunction or other grade ≥ 3 adverse events (AEs) occurred, iruplinalkib treatment would be suspended. At the discretion of investigator, iruplinalkib treatment would continue at the previous or a reduced dose after AEs reverted to grade ≤ 1 within 14 days. Two steps of iruplinalkib dose reduction to 120 mg and to 90 mg were allowed. If the same grade ≥ 3 AEs occurred again at a dose of 90 mg, treatment would discontinue. If dose suspension exceeded 14 cumulative days in a 21-day cycle or 14 continuous days, iruplinalkib dose discontinuation would also be required.