Discussion
Depression, hypothyroid, cancer, depressive disorder, depression, hypothyroidism
HYPOTHYROID, HYPOTHYROIDISM, CANCER, COMPLICATIONS
In this double-blind randomized controlled trial, the effect of synbiotic on complications of hypothyroidism was investigated. According to the findings of the present study, 10 weeks supplementation with 500 mg of 10Although significant improvement in serum FT4 level was observed in the within group analysis, the result of between group comparison and ANOVA analysis showed no significant changes. TSH level also remained unchanged after the intervention. This finding is in accordance with that of Talebi et al. [Depression was not significantly affected by the intervention in the present study. Observational studies have reported contradictory results regarding the existence of depression in hypothyroid patients [Participants of this trial had an average BDI score of ~15, which is categorized as mild depression (score = 14–19). It is evident that synbiotic supplementation affects depression in major depressive disorder and severe depression [QoL was significantly improved in hypothyroid patients after synbiotic consumption in almost all domains and areas, except for role limitations due to emotional problems. Unfortunately, our results are incomparable to that of other trials, as previous clinical trials in this regard have been performed among cancer patients [Health-related QoL is a multi-dimensional concept that implies the subjective assessment of different aspects of life and shows a person’s perception of the impact of ill health on daily life [In the present trial, administration of synbiotic for 10 weeks significantly reduced SBP and DBP. Probiotics have been reported to exert Angiotensin-converting enzyme (ACE)-inhibitory activity and play a role in γ-Aminobutyric acid (GABA) production, both of which lead to a reduction in blood pressure [