Author’ contributions
RECRUITMENT
Conception and study design: R.G.W. and M.Y.Z.; Patient recruitment: R.G.W., Y.Y.M.,Y.Z.Z,L.Y.,Y.Z., Q.L. and W.P.D.; Data analysis:R.G.W. and B.S.; Interpretation of data: R.G.W. and M.Y.Z.,and L.W.W; Writing up the first draft of the paper: R.G.W. and M.Y.Z.; Critical reviewing: Z.H. and L.W.W. All authors have read and agreed to the published version of the manuscript.