1. Introduction
RS, bowel cancer
BOWEL CANCER
The effects of resistant starch at high doses have been well-characterized, but the potential prebiotic effects of resistant starch at doses comparable to oligosaccharide prebiotics have not been evaluated. A three-arm randomized, double-blind, placebo-controlled clinical trial was conducted to evaluate the effect of 3.5 g and 7 g daily doses of SolnulResistant starch (RS) is defined as ‘the sum of starch and starch-degradation products that, on average, reach the human large intestine’ [While Australian dietary fiber levels approached those recommended by the National Health and Medical Research Council, bowel cancer rates remained high, and subsequent investigations revealed that RS levels in the Australian diet remained low (3–9 g per day; Commonwealth Scientific and Industrial Research Organization, Australia), suggesting that RS may play a valuable role among various forms of dietary fiber [Clinical trials evaluating the health benefits of RS fortification have typically investigated high doses in food formats, producing benefits including laxation [While current evidence suggests that higher doses of RS2 (i.e., 15–30 g/day) are needed to achieve metabolic improvements [