PopPK model diagnosis and assessment
As shown in Fig. S1, no remarkable deviations were found in the goodness-of-fit (GOF) plots of observed concentrations vs population predicted concentrations (PRED) and individual predicted concentrations, and conditional weighted residuals vs time or PRED. Bootstrap method was adopted to evaluate the stability of the model. All 500 bootstrap iterations successfully converged, with a success rate of 100%. As shown in Table S3, the medians of parameters calculated by bootstrap were generally consistent with the mean parameters predicted by the model. The parameters predicted by the model all fell within the 95% CIs of the bootstrap-calculated parameters, indicating the good stability of the model. The visual predictive check (VPC) results (Fig. S2) based on 500 simulations of contezolid plasma concentrations demonstrated that the final model had good predictive performance and could well describe the PK characteristics of the active ingredient contezolid in the human body after administration of contezolid acefosamil.In the final popPK model, 