4. Discussion
overweight
OBESE, TYPE 2 DIABETES
The STOP Sugars NOW Trial is a pragmatic, single-center, open label, randomized controlled multiple crossover trial with three four-week treatment phases (SSB, NSB, water) comparing the effect of the substitution of NSBs (“intended substitution”) versus water (“standard of care substitution”) for SSBs on the gut microbiota and glucose tolerance as well as other intermediate cardiometabolic outcomes in adults who consume ≥1 SSBs daily and are overweight or obese with a high waist circumference. The Ectopic Fat sub-study uses the same design to assess the effect on ectopic fat in liver (IHCL) by Baseline characteristics for both the main and Ectopic Fat sub-study were not different. Overall, the study participants in both the main trial and the Ectopic Fat sub-study represent an overweight or obese group with characteristics putting them at risk for type 2 diabetes and other NCDs.The NNS tested in the present trial are representative of those available on the market in Canada and globally [