Clinical outcomes
hand-foot, HFSR
Among the 27 patients who received treatment, the incidence of grade 3 or higher HFSR, which was the primary endpoint of the present study, was 7.4% (80% confidence interval [CI]: 2.0–18.5%), and the result of the exact binomial test assuming a threshold of 20% was statistically significant (P = 0.0718; Table 
Analysis results*: The result of the exact binomial test assuming a threshold of 20% was statistically significant (P = 0.0718)Abbreviations: HFSR, hand-foot skin reaction; CI, confidence interval; d, day; NC, not calculated.Table Table 
Reasons for treatment adjustmentAbbreviations: HFSR, hand-foot syndromeTreatment interruption occurred in 22 patients (82%) and dosage reduction occurred in four patients (15%; Table 