Author contributions
E.T.
J.v.d.H., S.N.O., N.V. and E.E.V. conceptualized the study. J.v.d.H., M.G., A.C. and L.R.H. curated the clinical data. L.R.H., D.J.P., K.S., L.S., G.T., I.V.Z., S.L., R.G., R.B., F.G., V.M., F.M., L.A., G.R., C.S., P.R., M.G.R., M.P., C. Morelli, T.I., F.Z., A.T., E.F., M.R., I.D., M.C., C. Messina, M.L., A. Petrillo, M.D.T., N.Z., O.G., J.G., R.L., S.M.G., A. Parisi, E.T., N.L.V., F.P. and V.R. acquired the clinical data. J.v.d.H. was responsible for the bioinformatics. J.v.d.H., S.N.O., X.M., P.W.v.d.H., S.M. and E.E.V. designed the in vitro experiments. S.N.O., X.M. and P.W.v.d.H. carried out the in vitro experiments. J.v.d.H., S.N.O., X.M. and P.W.v.d.H. carried out the formal analysis. E.E.V. acquired the funding. J.v.d.H., S.N.O., X.M., P.W.v.d.H., L.F.A.W., A.C., N.V. and E.E.V. devised the methodology. L.F.A.W., N.V. and E.E.V. supervised the study. J.v.d.H. and S.N.O. wrote the original draft. All authors contributed to reviewing and editing the final manuscript.