Statistical analysis
REGRESSION
The trial protocol included a sample size of 584, yielding 80% power to detect a Cohen’s Data were analyzed on an intention-to-treat basis. Patient characteristics are presented as proportions: mean (SD). Differences in baseline characteristics and HRQOL were compared using independent samples Comparisons were made between the reactive and active intervention groups and between the combined intervention groups vs the control group. Between-groups differences in mean changes in QLQ-C30 scores from baseline to 15 weeks after start of treatment were analyzed using multivariable linear regression analyses. Because we only compared 2 time points, multivariable linear regression analyses were conducted, adjusted for all confounding variables at baseline: baseline QLQ-C30 scale score, transfer sequence of the hospitals, and the baseline characteristics that were significantly different between the intervention groups. Group differences in mean change scores over time between the groups were accompanied by Cohen’s All analyses were performed in SPSS version 28.0. All tests were 2-sided with an assumed statistical significance level of a 