Participants.
SAD
The SAD and food effects study enrolled healthy adult participants (males and females of nonchildbearing potential) from 18 to 45 years of age. Health status was determined by medical history, physical examination, electrocardiogram (ECG), serum/urine clinical chemistry, hematology, and serology tests. Participants were excluded if they had a body mass index (BMI) outside the range of 18.0 to 32.0 kg/mThe MAD/EBA study enrolled male and female adults from 18 to 64 years of age with newly diagnosed (within the prior 3 months) rifampicin- and isoniazid-susceptible pulmonary TB. At screening, participants had to exhibit acid-fast bacilli (≥1+) in sputum per microscopic observation using WHO/IUATDL methodology (