Introduction
human infectious disease, arrest
ARREST, DISEASE, PARALYTIC POLIOMYELITIS, SMALLPOX
Following the eradication of smallpox, the extensive use of vaccines has nearly achieved the global eradication of a second human infectious disease, paralytic poliomyelitis. Wild polioviruses (WPVs) type 2 and 3 have been officially declared eradicated globally Additionally, administration of IPV in routine immunization is critical for the successful replacement of tOPV with bOPV. Although IPV protects the recipient from symptomatic disease through humoral immunity, it does not stimulate the robust mucosal immunity necessary at intestinal sites to arrest shedding One strategy to address supply shortages and limited intestinal immunity induced by IPV is the development of adjuvanted inactivated vaccines enabling use of fractional antigen quantities (dose sparing) while improving intestinal immunity 