Day 28 ACPR
RECURRENCES, REINFECTION
In the PP population, Day 28 PCR-adjusted ACPR was 80.8% (21/26; 95% CI 60.6, 93.4) with ferroquine monotherapy. There was a trend for higher efficacy with artefenomel co-administration, though efficacy was similar across the artefenomel doses: 90.3% (28/31; 95% CI 74.2, 98.0) with 300 mg, 90.9% (30/33; 95% CI 75.7, 98.1) with 600 mg, and 87.1% (27/31; 95% CI 70.2, 96.4) with 1000 mg (Fig. Day 28 PCR-adjusted ACPR and crude ACPR. PP populationBased on PCR-genotyping, there were 2/31 (6.5%) patients with reinfection in the ferroquine group, and 1/33 (3.0%), 2/36 (5.6%) and 0/32 (0%) with artefenomel 300, 600 and 1000 mg, respectively. Six of the recurrences had undetermined PCR results.Day 28 crude ACPR was 64.5% (20/31; 95% CI 45.4, 80.8) for ferroquine alone, with a trend for higher efficacy in the artefenomel arms: 81.8% (27/33; 95% CI 64.5, 93.0) with 300 mg, 77.8% (28/36; 95% CI 60.8, 89.9) with 600 mg, and 78.1% (25/32; 95% CI 60.0, 90.7) with 1000 mg (Fig. 