1. Introduction
non-alcoholic fatty liver disease, cardiometabolic abnormalities, Hypertension, hypertension, T2DM
OBESE, NON-ALCOHOLIC FATTY LIVER DISEASE, HYPERGLYCEMIA, METABOLIC DISEASES, INSULIN RESISTANCE, ADIPOSITY, HYPERTENSION, METABOLIC SYNDROME, HYPERTENSION, DYSLIPIDEMIA
This feeding trial evaluated the impact of the Dietary Approaches to Stop Hypertension diet on changes in plasma choline, choline metabolites, and ceramides in obese older adults; 28 adults consumed 3oz (n = 15) or 6oz (n = 13) of beef within a standardized DASH diet for 12 weeks. Plasma choline, betaine, methionine, dimethylglycine (DMG), phosphatidylcholine (PC), lysophosphotidylcholine (LPC), sphingomyelin, trimethylamine-N-oxide (TMAO), L-carnitine, ceramide, and triglycerides were measured in fasted blood samples. Plasma LPC, sphingomyelin, and ceramide species were also quantified. In response to the study diet, with beef intake groups combined, plasma choline decreased by 9.6% (Aging presents with body composition changes that include declines in muscle health with simultaneous increases in body fat. These changes increase the risk for cardiometabolic abnormalities such as insulin resistance, hyperglycemia, visceral adiposity, dyslipidemia, and hypertension [Choline, a micronutrient grouped with the family of B-complex vitamins, has received considerable attention due to its role in one-carbon metabolism, neurotransmission, membrane synthesis, and lipid transport [Ceramide is a sphingolipid that can be synthesized from the hydrolysis of sphingomyelin [The Dietary Approaches to Stop Hypertension (DASH) dietary pattern is a high-quality therapeutic diet known to improve health in vulnerable populations, resulting in improved cardiovascular and cognitive health and reductions in metabolic diseases, including T2DM, metabolic syndrome, and non-alcoholic fatty liver disease [