Outcome measures
SECONDARY
The main outcome was 28-day survival in both the derivation and validation cohorts. In the validation cohort, the secondary outcome was survival time within 28 days of follow-up period. We also estimated the treatment effects of PMX-HA on 28-day survival without any RRT (i.e., survival 28 days after ICU admission without ever receiving RRT) because the analysis was limited to patients who were treated without RRT in the derivation cohort.