Introduction
meniscus injuries, meniscus injury, Meniscus injuries, injuries
Meniscus injuries are the second most commonly occurring injuries to the knee.Stem cell-based regenerative therapy is an emerging and promising option for healing meniscus injury.To date, one double-blinded randomized controlled trialIn the present study, we found that hESCs-derived-IMRCs present strong immunomodulatory and pro-regenerative profiles when stimulated by synovial fluids from patients with meniscus injury. Endogenous fibrocartilage regeneration was observed in meniscal defect rabbits after IMRCs engraft. Following additional safety assays in cynomolgus monkeys, we conducted a phase I, dose-escalation clinical study (NCT03839238) and found that intra-articular injection of IMRCs in patients is safe with promising outcomes for meniscus injuries. To our knowledge, this is the first-in-human Phase I clinical study of IMRCs in meniscus injuries.