Statistical analysis
All collected data, including results from blood tests and questionnaires, were kept on a REDcap database. All linear statistical analyses were performed using SPSS version 26. Circular statistics were performed on Oriana version 4. Basic summary statistics were calculated for all outcome variables of interest and pertinent covariates. The Wilcoxon signed-rank test was used for repeated measures of nonparametric data, and the Hotelling 2-sample F-test was used for comparison of the circular data.