Generalisability
The results of this trial were from a single specialist clinic in Germany, which might reduce the applicability to other clinical settings. However, the eligibility criteria include most patients undergoing orthodontic-surgical treatment and the followed surgery protocol is widely used and well established.This study did not have the purpose to investigate gender differences in orthodontic surgical treatment and gender distribution within the study sample was not equal. This reflects the real clinical situation since women are more likely to accept surgical intervention than men [