Study endpoint
lethargy, bradycardia, arrhythmia, postoperative nausea and vomiting, pain, hypotension, PONV
ADVERSE EVENTS, SECONDARY, RESPIRATORY DEPRESSION, ARRHYTHMIA
The primary outcome was total propofol consumption. The main secondary outcomes were: procedure time (defined as the time from the insertion of the endoscope to the extraction of the endoscope); sedation time (defined as the time from administration of propofol to the end of the procedure); the incidence of adverse events (e.g., respiratory depression, hypotension, bradycardia, involuntary body movement, postoperative nausea and vomiting (PONV), lethargy, and arrhythmia); the essential vital signs (such as MAP, HR, SpO2) and RSS score at the following time points: before induction (T0), at the beginning of the procedure (T1), 10 and 20 min after beginning of the procedure (T2 and T3), after endoscope removal (T4). Additional secondary endpoints were: awakening time (defined as the time from the end of the procedure to spontaneous eye opening); recovery time (defined as the time from the end of the procedure to achieving a modified Aldrete score ≥ 9); the pain score at 30 min after procedure (measured by a visual analog scale (VAS) from 0 to 10; the higher the score, the more severe the pain); the satisfaction of endoscopists and patients (assessed by a VAS from 0 to 10; the higher the score, the better the satisfaction). Two anesthesiology residents assessed and recorded the clinical data.