Correlation of effect on active sputum NSP levels
REGRESSION
We were further interested in understanding any possible correlations among the sputum NSP activities. The three pairs of sputum NSP biomarkers are plotted in Fig. Correlation of sputum NSP activities from all treatment arms. Pearson correlation analysis within sputum NSPs at (The slightly less positive NSP correlation values post baseline suggested that there may have been an effect of treatment. Thus, the correlation analysis was repeated for each of the three dosing groups to identify if the NSP correlations for patients on brensocatib differed compared to those on placebo over the course of the trial: at baseline (Fig. Correlation of sputum NSPs in separate dosing arms at baseline only. NSP sputum correlation analysis was performed for placebo, 10 mg brensocatib and 25 mg brensocatib. Simple linear regression was plotted with the best-fit line plus 95% confidence intervalsCorrelation of sputum NSPs in separate dosing arms at Week 2. NSP sputum correlation analysis was performed for placebo, 10 mg brensocatib and 25 mg brensocatib. Simple linear regression was plotted with the best-fit line plus 95% confidence intervalsCorrelation of sputum NSPs in separate dosing arms at Week 4. NSP sputum correlation analysis was performed for placebo, 10 mg brensocatib and 25 mg brensocatib. Simple linear regression was plotted with the best-fit line plus 95% confidence intervalsCorrelation of sputum NSPs in separate dosing arms at Week 12. NSP sputum correlation analysis was performed for placebo, 10 mg brensocatib and 25 mg brensocatib. Simple linear regression was plotted with the best-fit line plus 95% confidence intervalsCorrelation of sputum NSPs in separate dosing arms at Week 24. NSP sputum correlation analysis was performed for placebo, 10 mg brensocatib and 25 mg brensocatib. Simple linear regression was plotted with the best-fit line plus 95% confidence intervalsCorrelation of sputum NSPs in separate dosing arms at Week 28. NSP sputum correlation analysis was performed for placebo, 10 mg brensocatib and 25 mg brensocatib. Simple linear regression was plotted with the best-fit line plus 95% confidence intervalsPearson correlation coefficients (r) for each pair of sputum NSP activities over the trial duration. Pearson correlation coefficients (r) are presented as mean for (