Physiologic Indices on OGTT
INSULIN SENSITIVITY/RESISTANCE
The serial 2 h 75 g OGTTs enabled assessment of physiologic indices reflecting insulin sensitivity/resistance and beta-cell function. Participants fasted overnight prior to each OGTT, with metformin held on the morning of the test. During each OGTT, venous blood samples were drawn at fasting and at 30-, 60-, 90- and 120-min post-challenge. Glucose, insulin and C-peptide were measured from these samples, as previously described in ref. 