Expression of different alleles in skeletal muscle
MINOR
Previous data have suggested that the rs2854464 polymorphism is located in a miR-24 binding site and that the major A allele has greater affinity for miR-24 leading to a reduction in ACVR1B mRNA. If this hypothesis was correct, it might be expected that there would be differential expression of the two ACVR1B alleles with the minor allele being expressed at higher levels. We therefore examined the GTEx dataset for single tissue eQTLs for rs2854464. Consistent with the hypothesis the expression of the minor allele was higher in skeletal muscle than expression of the major allele (