Introduction
cancer, T2D, CVD, chronic disease
CVD, CANCER, CHRONIC DISEASES, CHRONIC DISEASE
The role of lifestyle factors in health has been the object of numerous studies in recent decades. Most of the studies report a strong relationship between lifestyle and chronic disease morbidity and mortality [Because of the synergistic effect of lifestyle behaviors, several lifestyle scores have been proposed to assess the risk of chronic diseases. Some of these scores have been validated, demonstrating greater reductions in T2D or CVD risk compared to the expected reduction from the individual lifestyle factors included in the score [Various clinical trials have demonstrated that lifestyle interventions can have a beneficial effect on the intermediate metabolism and cardiovascular risk factors, reducing the risk of T2D or CVD incidence [Recently, two studies have identified metabolic signatures reflecting a healthy lifestyle pattern which were inversely associated with the risk of cancer [Therefore, the aim of the present study was to identify a metabolomic profile of the WCRF/AICR lifestyle score and to relate this metabolomic profile to the risk of T2D and CVD in a subset of participants of the PREvención con DIeta MEDiterránea (PREDIMED) study.