Statistical analysis
All analyzes were performed using STATA software version 14. Quantitative variables were summarized using mean, standard deviation and median. Qualitative variables were reported in frequency and percentage. Baseline characteristics between the three groups were tested using ANOVA. The comparison within groups was performed by two-tailed paired Student’s t-test or with the Wilcoxon rank t test. Chi-square person test were used to compare the frequencies between classification variables. The difference between the three groups was tested using the ANOVA test and Benferoni post hoc test. P value less than 0.05 was considered statistically significant. The maximum observed concentration (C-max) and the time at which this occurred (T-max) were calculated. The area under the plasma concentration–time curves from zero to the last sampling time AUC0-24 was calculated according to the trapezoidal rule using the actual times of measurements. Analysis of covariance (ANCOVA) was performed on AUC, Tmax and Cmax using STATA software version 14. ANOVA results revealed the effect of the sources of variation like sequence, subjects in a sequence, period and formulation on the bioequivalence data. The results of ANCOVA were calculated at 5% level of significance.