What was known before
diabetic retinopathy, hyperprolactinemia, diabetic macular oedema
DIABETIC RETINOPATHY, PROLIFERATIVE DIABETIC RETINOPATHY, DIABETIC MACULAR OEDEMA, RETINA, HYPERPROLACTINEMIA

Elevation of systemic prolactin leads to the intraocular accumulation of vasoinhibin, a proteolytic fragment of prolactin that inhibits the excessive permeability and growth of blood vessels in the retina.The prokinetic oral medication, levosulpiride, induces hyperprolactinemia and elevates the levels of vasoinhibin in the retina of diabetic rats and in the vitreous of patients with proliferative diabetic retinopathy.Levosulpiride may have beneficial outcomes in diabetic macular oedema and diabetic retinopathy due to the vascular properties of vasoinhibin.