Pharmacokinetics
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The mean plasma concentrations of selnoflast over the treatment period are depicted in Figure Selnoflast plasma concentrations (mean ± SD) versus time. Treatment showed a rapid increase and limited accumulation over 7 days. Steady state was achieved on Day 2. The inter‐patient variability was low to moderate. Mean plasma concentrations remained above the ICSummary of selnoflast plasma pharmacokinetic parameters at Day 1 and at steady‐state (Day 5).
Abbreviations: AUCConcentration of selnoflast in sigmoid colon mucosal tissue. Selnoflast concentrations were measured in sigmoid colon biopsies from individual patients, taken 2–4.5 h post‐dose on Day 7. The dotted line represents the tissue IC