References
diabetic”, diabetic, diabetes
IMPAIRED GLUCOSE TOLERANCE, DIABETES
Example dynamics generated from the model in Equation (1). The blue curve is characterized by a fast biphasic response to the MMTT, thus having high frequency (Model fit to postprandial breakfast MMTT response at baseline of 16 randomly selected representative subjects. Here, points represent measurements, and lines represent the fitted model values.Joint parameter distribution obtained by fitting the model in Equation (1) to the postprandial breakfast MMTT data. The blue and red colors represent clusters A and B, respectively. The diagonal represents histograms of the parameter distribution (color-coded by transparent cluster color), and the off-diagonal represents pairwise joint distributions. Note that overlapping colors appear brown.Baseline postprandial breakfast MMTT response color-coded by the clusters.Baseline joint distribution of diabetes risk markers, which had significant associations with clusters. The diagonal represents histograms of the parameter distribution (color-coded by transparent cluster color), and the off-diagonal represents pairwise joint distributions. Note that overlapping colors appear brown.Baseline joint parameter distribution obtained by fitting the model in Equation (1) to the postprandial MMTT data. The different markers (dots, triangles, and asterisk) represent subjects classified as “normoglycemic”, “impaired” glucose control, or “diabetic”, respectively. Here, we used the OGTT measurement after 2 h and classified normal glycemic regulation as <7.7 mmol/L, impaired glucose tolerance in the range of 7.8–11.0 mmol/L, and diabetic ≥ 11.1 mmol/L. The diagonal represents histograms of the parameter distribution (color-coded by transparent cluster color), and the off-diagonal represents pairwise joint distributions. Note that overlapping colors appear brown.Week 12 joint parameter distribution obtained by fitting the model in Equation (1) to the postprandial breakfast MMTT data. The blue and red colors represent clusters A and B, respectively. The diagonal represents histograms of the parameter distribution (color-coded by transparent cluster color), and the off-diagonal represents pairwise joint distributions. Note that overlapping colors appear brown.Food composition and nutrients of standardized meals.* Edible amount.Baseline characteristics of the subpopulations analyzed in MMTT, OGTT, and fecal microbiota. There was no significant difference between treatment groups.