Definition of events
Confirmed disability, a disability increase
CDA
Confirmed disability accumulation (CDA) was defined as a disability increase from the previous assessment measured by EDSS of ≥ 1.0 points if baseline EDSS was ≤ 5.5 points or a ≥ 0.5-point increase if baseline EDSS was > 5.5 points, confirmed at a third visit after 12 or more weeks