Participants
cognitive decline, memory impairment, UC
BROWN
Participants were enrolled in the POINTER Imaging study, an ancillary study of the POINTER clinical trial that is testing whether random assignment to either of two multidomain lifestyle interventions (focusing on nutrition, physical exercise, cognitive/social stimulation, health monitoring) that differ in format, intensity and accountability affects 2-year cognitive trajectory. POINTER trial participants are aged 60-79 years, lack significant memory impairment, are sedentary, report a sub-optimal diet, and are at risk for future cognitive decline based on family history of memory impairment, race or ethnicity, and/or other risk factors (POINTER Imaging participants were recruited from the communities surrounding five sites: UC Davis, Wake Forest University School of Medicine, Rush University and Advocate Aurora Health (combined Chicago site), Baylor College of Medicine, Kelsey Research Foundation and Houston Methodist (combined Houston site) and Brown University / Merriam Hospital and Butler Hospital (combined New England/Rhode Island site). The complete baseline dataset from the POINTER parent trial, including neuroimaging data, will be made available when enrollment and dataset curation has concluded. Publicly available neuroimaging data will be accessible via LONI by any qualified investigator that has formally agreed to the POINTER Imaging data use agreement. The central Institutional Review Board (IRB) at Wake Forest University School of Medicine approved this study, with concurrence by local site IRBs. All participants provided written informed consent.