Conclusions
obesity, PCOS
INSULIN RESISTANCE, OBESITY, OBESE, ANDROGEN EXCESS
This study shows preliminary findings that a 12-week combined treatment with beinaglutide and metformin was more effective in weight reduction and a decrease in BMI and WC compared to metformin alone in obese women with PCOS.COMB treatment was also more effective in the improvement of androgen excess and insulin resistance of PCOS women with obesity, with acceptable short-term side effects. Although this evidence is not definitive, it provides new ideas for combination regimens of PCOS patients who respond poorly to metformin. More large-scale, long-term randomized clinical trials for comparison of beinaglutide TID with metformin, as well as cost-effectiveness analysis are necessary to guide the use of beinaglutide as a therapy of PCOS.