Pre-existing intratumoral T cells and clinical efficacy
tumor
TUMOR
To assess the temporal dynamics of intratumoral and peripheral T cells in response to neoadjuvant PD-L1 blockade, TCR-β sequencing was performed in serial peripheral blood and tumor tissue. Intratumoral TCR diversity was significantly increased in well responders and was positively correlated with the pathological response at the time of surgery compared with poor responders (Fig. 