Introduction

BRAIN, CORTEX
Secretin is the first hormone ever discovered, and its best-known effect is the induction of pancreatic exocrine secretion [As the sympathetic nerves controlling BAT thermogenesis harbor afferent sensory fibers projecting to the brainstem, the midbrain, and the forebrain [Satiation is linked with altered patterns of neural activations in the cortex [Brain BOLD activity is tightly linked with regional brain glucose metabolism at both resting state [In the current study, we specifically investigated the central mechanism of secretin mediated satiation, extending our placebo controlled GUTBAT Trial study [