Patient and disease characteristics
LATE SURGICAL COMPLICATION
Between 9 September 2011 and 6 March 6 2020, 443 patients consented to randomization at eight sites; 221 and 222 patients were allocated to the EAC arm and the CAC arm respectively (Flow diagram of study populationEAC, early adjuvant chemotherapy; CAC, conventional adjuvant chemotherapy.A total of 43 patients (17 in the EAC arm and 26 in the CAC arm) did not receive treatment as per the study protocol. In the EAC arm, two patients could not initiate AC due to the late surgical complications, and 39 patients (15 in the EAC arm and 24 in the CAC arm) received other regimens for AC, including intravenous fluorouracil/leucovorin (FL), oral capecitabine, and oxaliplatin with oral capecitabine. The safety population included 380 patients (192 in the EAC arm and 188 in the CAC arm) because safety data were missing for 2 patients in the CAC arm. The QoL population included 280 patients (148 in the EAC arm and 132 in the CAC arm) because QoL data were missing for 100 patients (44 in the EAC arm and 56 in the CAC arm) among the safety population.The baseline and pathological characteristics of the ITT population, the safety population, and the QoL population are shown in Baseline characteristicsValues are 