Results
NAFLD, sleep traits
NON-ALCOHOLIC FATTY LIVER DISEASE
We investigated the correlation of different sleep traits with NAFLD, with the IVW method providing the main results, while the results of the MR Egger and weighted median methods were also presented by us. Processes with P value < 0.05 for the IVW method and F value > 10 were considered as significant associations. We present the statistically significant results in Mendelian randomized analysis of positive results presented.NAFLD, non-alcoholic fatty liver disease, OR, odds ratio, SNP, single nucleotide polymorphism, MR, mendelian randomized.As shown in the Scatter plots of six resules. The black dot denotes the genetic instrumental variable included in the Mendelian randomization analysis. The grey error bar denotes the 95% confidence interval of the coefficient for each genetic instrumental variable. NAFLD, non-alcoholic fatty liver disease, SNP, single nucleotide polymorphism, MR, mendelian randomized. In addition, statistical difference verification of the weighted median method could be obtained for most of the above results (P<0.05).However, we could not obtain any statistically significant results when representing data related to NAFLD as an exposure factor and data related to sleep traits as an outcome factor for reverse causality validation (P<0.05). Although some of the results exhibit heterogeneity when tested using Cochran’s Q test (p>0.05), since we used random effects IVW as the main outcome, the heterogeneity is acceptable and it does not invalidate the MR estimates in the current study (Next, we perform a sensitivity analysis using the leave-one-out method, which is shown in the forest plot. As seen in the plot, basically all lines are on one side of the y-axis, and even beyond the axis they are not too far away, so it is clear that the results we are exploring are more robust. Forest maps of six results are shown with the results, as shown in Forest maps of six resules. The vertical axis represents the number assigned to each SNP, while the horizontal axis represents the confidence interval. The red line segment corresponds to the confidence interval category of the entire sample, while the gray line segment corresponds to the confidence interval category of each SNP sample. NAFLD, non-alcoholic fatty liver disease, OR, odds ratio, SNP, single nucleotide polymorphism, MR, mendelian randomized. 