The auto‐abs neutralization IFN‐α2 in vitro
infection
INFECTION
Overall, samples from patients with auto‐Abs against IFN‐α2 have neutralizing activity to IFN‐α2 and limit the antiviral activity of IFN‐α2 against MERSpp (Figure Increased MERS pseudotyped viral particles' (MERSpp) infection, despite the presence of interferon (IFN)‐α2, in the presence of plasma with autoantibodies (auto‐Abs) targeting IFN‐α2. MERSpp infection measured 48 h after infection in Huh7.5 cells treated with IFN‐α2 in the presence of plasma from patients with auto‐Abs or without auto‐Abs. Samples from patients with positive auto‐Abs for IFN‐α2 (