Study participants
AKI, sepsis
SEPSIS
This was a single-center double-blind randomized clinical trial that screened all consecutive patients admitted for AKI who met the diagnostic criteria for sepsis and had been evaluated by the Nephrology Department at the Hospital Civil de Guadalajara Fray Antonio Alcalde, a large referral center that cares for patients without health care insurance and with low socioeconomic status in Jalisco, México.Patients were enrolled from February 2019 to March 2022. Due to the COVID-19 pandemic, we enrolled patients at a slower rate and over a relatively long period (2019 through 2021). The trial was conducted in accordance with the principles of the Declaration of Helsinki and the International Conference on Harmonization Guidelines for Good Clinical Practice. All patients gave their written informed consent before any study-related procedure. The study, which was approved by the local ethics committee (HCG/CEI-1342/18), was prospectively registered in clinicaltrials.gov (NCT03877081) on 03/15/2019. No funding was received to conduct this study.