Introduction
aggressive primary malignant brain, Glioblastoma, tumor
BRAIN TUMORS, GLIOBLASTOMA
Glioblastoma (GBM) is the most common and most aggressive primary malignant brain tumor, with an incidence of 3–5 cases per 100.000 people in Europe [Although many efforts have been made to improve current therapies, patients with GBM face a poor prognosis, with a median survival of just 9–18 months [In recent years, laser interstitial thermal therapy (LITT) has been developed as a minimally invasive treatment for brain tumors, especially in cases where surgery is not deemed safe [The aim of this pilot study was to examine the feasibility of conducting a randomized controlled trial (RCT) investigating LITT in patients with an irresectable nGBM and to identify any safety or technical feasibility issues to further refine the design of a larger full-scale multicenter RCT.