Ethics approval and consent to participate
This study was approved by the Ethics Committee of the Medical faculty at Heidelberg University (S-634/2018) and preregistered with the German Clinical Trials Register (DRKS00015812). All procedures performed in studies involving human participants were in accordance with the ethical standards of the research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Prior to study participation written informed consent was obtained from all individual participants included in the study, and they were able to raise questions with the study team who answered them.