Follow-up
toxicity, death
ADVERSE EVENT, RECURRENCE
The first follow-up visit included physical examination and full blood count and was performed 4 weeks after surgery. Chest CT scan and abdominal-pelvic CT scan or MRI were performed every 6 months in the first 5 years and yearly thereafter. Local control was calculated from the date of diagnosis to the time of local–regional failure or last follow-up. Disease-free survival was defined as the time from diagnosis to local or distant recurrence or last follow-up. Overall survival was defined as the time from diagnosis until death from any cause or last follow-up. Acute and late toxicity data were scored according to the Common Terminology Criteria for Adverse Events (CTCAE v4.03). Quality of Life was evaluated using the EORTC QLQ-C30 questionnaire at the beginning and at the end of radiotherapy.