Effect of alcohol dose on inhibitory control behavioral metrics
In order to assess the effect of alcohol dose on inhibitory control, we first computed participants’ behavioral performance on the Go/No-go tasks before and after alcohol consumption (henceforth referred to as pre and post respectively). These metrics include the subject’s performance (measured as d-prime in go-no-go blocks) and their reaction times (during go-no-go blocks).We noted that pre performance and post performance were strongly correlated for all doses, but this relationship deteriorated progressively with higher doses (placebo: r = 0.75; low: r = 0.51; moderate: r = 0.45) (Fig. Main effect of alcohol level on task performance as measured by d-prime. (To quantify these observations, we ran a two-way repeated measures ANOVA to model each behavioral metric using factors pre/post, alcohol dose, and their interaction term. We found that the interaction between pre/post and dose was a significant factor in d-prime (p = 0.003), but not the reaction time (p = 0.200). For reaction time, only the main effect of pre/post was deemed significant (p = 0.037; Supplementary Fig. 