Pathological review
tumor, extranodal extension, GvL
TUMOR, LYMPH NODE METASTASIS, RESIDUAL CANCER
All formalin-fixed, paraffin-embedded (FFPE) tissue specimens are reviewed centrally by an experienced uropathologist (GvL). The presence of residual cancer cells is assessed, as well as tumor grade (WHO 1973 and 2004/2016), the presence and proportion of divergent differentiation and urothelial subtypes, lymphovascular invasion, concomitant CIS, surgical margins status, the number of resected lymph nodes and lymph node metastasis, as well as the presence of extranodal extension.