Characteristics of Patients With HCC by Antidepressant Use Before or After Diagnosis
death, HCC, hepatocellular carcinoma, HCC, Comorbidity
Abbreviations: CCI, Charlson Comorbidity Index; HCC, hepatocellular carcinoma; NA, not applicable; RFA, radiofrequency ablation; SNRI, serotonin-norepinephrine reuptake inhibitor; SSRI, selective serotonin reuptake inhibitor; TACE, transcatheter arterial chemoembolization; TAE, transcatheter arterial embolization; TCA, tricyclic antidepressant.Without an antidepressant prescription in the 1 year before the HCC diagnosis.Without an antidepressant prescription in the 1 year before and after the HCC diagnosis.Comorbidity before HCC diagnosis.Procedures and medication use recorded after HCC diagnosis.For comparisons of antidepressant use prior to diagnosis, antidepressant use was defined as having at least 1 antidepressant prescription in the 1-year exposure window prior to HCC diagnosis, regardless of prior antidepressant use. Nonuse was defined as individuals who had no prescriptions for antidepressants in the 1-year exposure window prior to HCC diagnosis.For comparisons of antidepressant use after diagnosis, those taking antidepressants were defined by at least 1 antidepressant prescription in the exposure assessment window after the date of first HCC diagnosis to death or the end of 2017. Antidepressant use was considered as a time-varying exposure to avoid potential immortal time bias.