Background
postoperative pain, postoperative nausea/vomiting (PONV, hyperalgesia, peripheral nerve block, cancer, Breast cancer, pain, Chronic pain, improves pain, NRS
CANCER PROGRESSION, CANCER, BREAST CANCER, MINOR, CHRONIC PAIN, COMPLICATIONS
Breast cancer is the most common cancer among women [Approximately half of women who undergo minor or major breast surgery describe an important postoperative pain (> 5 on the Visual Analogue Scale, VAS) which is not always effectively controlled by standard post-operative therapies [Post-operative analgesia in breast surgery is difficult due to the extensive nature of the surgery and the complex innervation of the breast and poor postoperative pain control may produce a series of acute and chronic complications [Associating general anesthesia (GA) with regional anesthesia techniques, improves pain control, reduce the perioperative need of analgesic drugs, in particular reducing opioid requirements during the perioperative period according with the enhanced recovery programs, diminish postoperative nausea/vomiting (PONV), help in reducing the development of chronic pain, and facilitate early rehabilitation [Although using regional blocks as an adjunct to analgesia existed for many years, they have only recently increased in popularity as a method of postoperative pain management.Pectoralis blocks (PECS 1 and PECS 2), Serratus anterior plane (SAP) block [Chronic pain is a problem that afflicts about half of women undergoing radical mastectomy [Proposed mechanisms for decreasing persistent pain include decreasing central sensitization (wind-up) and reducing opioid-induced hyperalgesia [The role of local anesthetics (LA) given for the peripheral nerve block in affecting post-operative nerve impulse activity, in slowing the changes in synaptic neuroplasticity, or in changing the signaling properties of non-neuronal cells has been debated for the past two decades [Furthermore, regional anesthesia may reduce cancer progression by attenuation of the surgical stress response, better analgesia, and reduced opioid usage, and by the direct protective action of local anesthetics on migration of cancer cells [This randomized comparative study, which was carried out on 82 patients who underwent radical mastectomy, aims to compare the efficacy of TPV block with a simpler technique to perform such as the ESP block.Primary aim was comparing the efficacy of TPV block and ESP block on the postoperative pain intensity expressed as Numeric Rate Scale (NRS).