Statistical Analysis
arrest, caries
REGRESSION, ARREST, CARIES
Statistical analysis is reported through March 2022. Our approach for noninferiority followed established guidelines.Our noninferiority margin was predetermined to be 10% as the maximum clinically relevant difference and also agrees with the fixed margin method when comparing our active control with a placebo, in which prior investigations showed a prevalence of pit or fissure dentin caries of 1.6% vs 4.6% for dental sealants vs placebo and a risk reduction of 10% among children receiving sealants and atraumatic restorative treatment.Intention-to-treat analysis was performed using multiple imputation. Five imputed data sets were generated for the full follow-up sample (N = 2998). Imputed data sets were then separated for arrest and prevention outcomes, following primary analysis procedures, and analyzed using logistic regression. Analysis was conducted in Stata, version 17 (StataCorp LLC) and R, version 1.4 (R Group for Statistical Computing). All 