State-related effects
In the propofol group, disconnectedness was associated with relatively lower glucose metabolism bilaterally in the thalamus, hippocampus, amygdala, nucleus accumbens, nucleus caudatus, and globus pallidus (State-related effects. Relationship between disconnectedness and CMRNext, we used conjunction analysis to investigate consistent effects related to disconnectedness across treatments. Since the within-treatment group comparisons suggested different consciousness-related mechanisms for S-ketamine compared with other treatments, only propofol, dexmedetomidine and sevoflurane groups were included. An overlapping effect of decreased metabolism was observed mainly in the thalamus bilaterally, and to lesser extent in the left anterior temporal fusiform gyrus (Since the thresholds for state classification were defined Next, CMRGlucose metabolism in the central medial thalamus in connected and disconnected states. Boxplots for absolute glucose metabolism at the peak effect location (central medial thalamic nucleus) from the conjunction analysis. Thalamic CMRThalamic glucose metabolism was more strongly correlated with the state of consciousness than with the measured drug concentration. 