Statistical analysis
REGRESSION
IBM SPSS software package version 20.0. (IBM Corp., Armonk, NY,) was used for the data analysis. Qualitative data are represented as numbers and percentages, and the Chi-square test was used to compare the two study groups. Quantitative continuous data were tested for normality using the Shapiro-Wilk test and expressed as range (minimum and maximum), mean, standard deviation, and median. When quantitative variables were not normally distributed, the Mann-Whitney test was applied to identify intergroup differences. The results were judged at a 5% level of significance [Statistical analysis showed that the half-maximal inhibitory concentration (IC50) of the Carie-Care™ gel was analyzed by a non-linear regression test using GraphPad Prism 8.0.1.