Statistical methods for primary and secondary outcomes {20a}
TTP
TTP
To establish an exposure-response model for DZD, the change in liquid culture MGIT time to positivity (TTP) will be modelled and linked to derived PK metrics. The model for TTP will be based on a previously develop and published model, linking a latent variable describing the decline in bacterial load to a model of probability of detection in MGIT (handling negative samples) and a time-to-event model for TTP [