Rabbit treatment
ANTHRASIL and placebo were administered when PA was detected (≥1.5 ng/mL) in blood using a real-time electrochemiluminescence (ECL) immunoassay as the trigger for treatment on an individual basis. ANTHRASIL was given at a single dose of 15 U/kg and the placebo was administered as a single dose of equivalent volume. For both groups, the infusion duration was approximately 2.5 h. The ANTHRASIL dose was selected based on a previous dose-range study (