Trial Design
The KONOTORI trial was an unblinded, single-center, EHR-nested, parallel-group, superiority randomized controlled trial (RCT). This trial was conducted at the Department of Psychiatry of Toyooka Hospital, a tertiary-care community hospital in Toyooka City, Hyogo, Japan. The details of the trial design have been previously published (University Hospital Medical Information Network Clinical Trials Registry: UMIN000033633) [All procedures contributing to this work were compliant with the ethical standards of the relevant national and institutional committees on human experimentation and the Helsinki Declaration of 1975, as revised in 2008. The study protocol was approved by the Ethics Committee of Kyoto University Graduate School of Medicine and the Institutional Review Board of Toyooka Hospital (C1401). All patients provided written informed consent prior to enrollment. This study followed the Consolidated Standards of Reporting Trials statement [