Treatment delivery
At the time of data cutoff (June 30, 2015) for the final analysis, all patients had completed treatment. The median number of treatment cycles was three (range: 1–18). Three patients (10.0%) required a dose reduction of CPT‐11, and 15 patients (50.0%) required a delay in treatment cycles. The administration of CPT‐11 on day 8 was omitted in three patients (10.0%). Six patients (20.0%) required a dose reduction of S‐1, while seven patients (23.3%) required cessation of S‐1 in the treatment cycles (Table Treatment delivery.
