Mean Methadone Doses at Various Intervals Up to 90 Days
Mean group methadone doses are shown for postentry into treatment. Mean values include data that were available for people retained at each time point. Treatment as usual (TAU): 47 individuals retained at 7 days, 43 at 15 days, 38 at 30 days, 37 at 45 days, 34 at 60 days, and 33 at 90 days. Conditioned open-label placebo (C-OLP): 73 individuals retained at 7 days, 71 at 15 days, 67 at 30 days, 65 at 45 days, 64 at 60 days, and 60 at 90 days. Whiskers indicate 95% CIs.Subanalysis 1 included only individuals who had maintained a stable dose of methadone during the last 2 weeks of treatment (15 TAU, 32 C-OLP). There was no significant difference between the groups in mean (SD) 90th-day methadone dose (85.3 [13.4] mg for TAU, 87.0 [15.6] mg for C-OLP; t