Discussion
breast lesions
In this study, we found that high-temporal-resolution DCE-MRI was superior to conventional low-temporal-resolution DCE-MRI in diagnostic performance for BI-RADS category 4 breast lesions based on pharmacokinetic parameters from intralesional and perilesional areas, but not parameters from background parenchymal enhancement. Low-temporal resolution DCE-MRI, which is merely similar to perfusion imaging, is not suitable for perfusion analysis and cannot truly reflect the microvascular state of lesions. Moreover, Peri_VRegarding hemodynamic parameters from high-temporal-resolution DCE-MRI, our results showed that some parameters had good discrimination performance in the intralesional area (AUC_KRelative to high-temporal-resolution DCE-MRI, some parameters (Lesion_KBased on the AUC values of pharmacokinetic parameters from high- and low-temporal-resolution DCE-MRI, our results showed that the Lesion_KInterestingly, the hemodynamic parameters of the BPE area from high-temporal-resolution resolution DCE-MRI were not effective for discrimination, but the KOn the other hand, our study showed that Peri_VThere were several limitations in this study. First, the sample size was relatively small, and further study with a larger number of patients is needed to confirm our results. Second, high-temporal-resolution DCE-MRI scans still need further optimization of scanning time and have the same slice thickness as conventional DCE-MRI. Third, the current study did not analyze qualitative and semiquantitative factors, such as time–intensity curves, washin/washout rate, and signal enhancement ratio. In our subsequent work, we will perform a prospective study to compare the diagnostic performance of qualitative analysis and semiquantitative analysis in conventional low-temporal-resolution DCE-MRI. Fourth, the AIF is essential to calculate kinetic parameters; therefore, we must further compare the different methods for drawing this function from conventional low-temporal-resolution DCE-MRI, such as drawing the AIF from the thoracic aorta or basing it on a reference tissue.