Statistical methods for primary and secondary outcomes {20a}
CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY
The primary endpoint (grade 2 or higher chemotherapy-induced peripheral neuropathy) will be compared between the two groups by chi-squared test. A significance level of 0.05 (two-sided) will be kept for analysis.Descriptive information on patient demographic, clinical, and treatment characteristics, along with other study outcomes will be provided via mean, standard deviation and range or median, interquartile range and range for continuous variables, frequencies, and proportions for categorical variables. Continuous variables will be evaluated for normality and log transformation will be done, if necessary. Study outcomes will be compared between groups using standard statistical methods—chi-squared test for the primary variable, 