Statistical analysis
The Statistical Package for the Social Sciences (SPSS) software package version 22 was used for all analyses (SPSS Inc., Chicago, IL, USA). Baseline and 24-weeks characteristics were represented as mean ± SD for continuous variables and frequencies (percentage) for nominal variables. The final analysis was based on a modified intention to treat (ITT) analysis where patients who have attended the middle follow-up appointment in the 12th week were considered in the final analysis. Missing data were predicted by multiple imputation (MI) based on the average of five iterations.Paired and unpaired 