Study protocol of the CLOCK trial
ischemia, tumor, hypotension
ISCHEMIA, TUMOR, BLIND
The CLOCK trial (ClinicalTrials.gov NCT 02287987 [Pre- and postoperative management were handled by physicians/nurses not directly involved in the surgical procedures and blind of the randomization results. The CKD-EPI equation [The surgical steps were strictly regulated by the study protocol: for both arms, kidney defatting and renal artery isolation were mandatory. In the on-clamp arm, at least the tumor resection and the inner renorrhaphy were required to be completed under global ischemia; in the off-clamp arm, the renal artery had to remain unclamped along all the procedure. Controlled hypotension during resection was not allowed. The specimens were examined according to the international guidelines by experienced uro-pathologists blinded from the clamping approach.