Study protocol
hemodialysisIntradialytic hypotension, hypotension
The study procedures were performed in the Vanderbilt University General Clinical Research Center (GCRC). Patients participated in a randomized placebo-controlled two by two crossover study, in which they received either, the bradykinin B
Study design. The study was a randomized, cross-over, double-blind, placebo-controlled study to study the effects of icatibant in mitochondrial function and blood pressure during hemodialysisIntradialytic hypotension was defined as a reduction of SBP equal to or greater than 20 mmHg during hemodialysis. We restricted the analysis of blood pressure to the first three hours of hemodialysis since the duration of hemodialysis varies from 3.25 to 4.5 h and most episodes of hypotension occurred during the first hour of hemodialysis.