Introduction
endometrial cancer, tumor, diarrhea, inflammation, cervical cancer, deaths
ADVERSE REACTIONS, ENDOMETRIAL CANCER, TUMOR, INFLAMMATION, URINARY TRACT BLEEDING, CERVICAL CANCER, CAVITY, RECTAL BLEEDING, DISEASES
The increasing number of cervical cancer (CC) and endometrial cancer (EC) cases and the high mortality from these diseases are a serious concern for women's health. Worldwide, there were an estimated 604,127 new cases and 341,831 deaths attributed to CC in 2020, and a further 417,367 new cases and 97,370 deaths attributed to ECRadiotherapy is associated with adverse reactions such as diarrhea, rectal bleeding, urinary tract bleeding, and vaginal radiation toxicityRecently, accumulating evidence has highlighted the influence of mutualistic bacterial communities, such as intestinal microbiota and vaginal microbiota, on human healthGynecological tumor patients have distinct vaginal microbiota profiles compared to healthy women. Radiotherapy leads to even greater changes in the vaginal microbiota, characterized by the enrichment of opportunistic bacterial pathogensSeveral studies have found that probiotics combined with radiotherapy could inhibit microbiota dysbiosis and local inflammation of mucosal surfaces, such as the intestinal tract and oral cavity, by restoring micro-environmental homeostasis and regulating the immune systemIn the present study, 