Discussion
Type 2 diabetes, inflammation, diabetes mellitus, vascular diabetes complications, diabetic, weakness, T2DM
TYPE 2 DIABETES, INFLAMMATION, DIABETES MELLITUS, INSULIN RESISTANCE, DIABETES TYPE 2, OXIDATIVE STRESS, INSULIN SENSITIVITY
This is the first study to report the effect of InsP6 supplementation on adiponectin levels in T2DM patients. Our findings are consistent with other rodent experimental investigations. In a recent study, dietary myo-inositol supplementation boosted adiponectin plasma levels in C57BL/6 mice fed a high-fat diet [Other authors discovered that dietary myo-inositol significantly enhanced blood adiponectin levels, but dietary phytic acid somewhat increased them when rats were fed a high sucrose diet containing 1.02% sodium phytate or 0.2% myo-inositol for 12 days [In addition, some “in vitro” results confirm these findings and show that the impact of legumes on insulin sensitivity may be mediated, at least in part, by InsP6 or InsPs. A recent study focused on the nutritional and physiological similarities between InsP6 and myo-inositol, and it showed that myo-inositol and myo-inositol phosphates enhance insulin sensitivity in “in vitro” models with adipocytes by boosting lipid storage capacity, enhancing glucose absorption, and suppressing lipolysis [Accordingly, Inositol, or myo-inositol, and its analog compounds (including InsP6 and the other InsPs) are known to have favorable biological qualities and are now being explored extensively. The impact of these chemicals on diabetic indicators is important, especially given the enormous worldwide cost of treating diabetes mellitus and its consequences. Type 2 diabetes is a chronic condition that is recognized to be characterized by low-grade inflammation, which plays an important role in vascular diabetes complications and development [Myo-inositol hexaphosphate (phytate, InsP6) is a natural chemical found in seeds as a calcium-magnesium salt (phytin) and has been shown to regulate enzymes involved in lipid and carbohydrate metabolism. Furthermore, InsP6 lowers food intake, calorie consumption, and modifies adipose tissue cytokine production [We discovered that the InsP6 diet had an effect on blood lipid levels. Depending on the InsP6 salt utilized, different studies have observed varying effects on lipid metabolism. On the one hand, sodium InsP6 inhibited lipase activity, resulting in a considerable drop in total cholesterol and low-density lipoprotein while increasing high-density lipoprotein [InsP6 is linked to inflammation and insulin resistance [There were some limitations to the current investigation. The first is the small sample, we only examined 39 patients from a single medical center. Consequently, our findings may be restricted in their generalizability. Another weakness of this study is that the experiment (dietary intervention) was not blinded. As a result, a large multicenter, blinded placebo-controlled trial is required to validate our findings.As conclusion, our study has demonstrated that daily phytate intake increases adiponectin levels among patients with diabetes type 2. So, our findings indicate that following a phytate-rich diet has beneficial effects on adiponectin concentrations. Adiponectin is an antidiabetic, anti-inflammatory factor and reduces oxidative stress [