2.6. Randomization and stratification
CIN
CIN
The patients are randomized 1:1 in a centralized block randomization manner to be allocated to either the same-day or the next-day arm. The randomization is stratified according to number of patient’s CIN risk factors (1 vs ≥ 2), chemotherapy setting (perioperative vs palliative), and interval of regimen (2-week vs 3-week). This clinical study is an open-label trial; both the investigator and the patient know which method is being administered.