Intervention
Participants started memantine no earlier than 4 weeks prior and no later than 1 week after their first cycle of chemotherapy. The dose was titrated as follows: 5 mg daily in week 1, 5 mg BID in week 2, 5 mg each morning, and 10 mg each evening in week 3, then 10 mg BID in week 4. Participants continued 10 mg BID (or highest tolerated dose) until 4 weeks after (range: 2–12 weeks) their final cycle of chemotherapy.