Conclusion
peripheral arterial occlusive disease
PERIPHERAL ARTERIAL DISEASE, PERIPHERAL ARTERIAL OCCLUSIVE DISEASE, DISEASE PROGRESSION
In conclusion, walking training induces changes in circulating miRNA expression in patients with peripheral arterial disease. These changes only occur during moderate walking training for at least 20 min. Future studies are needed to find out whether (1) longer intensive training sessions, e.g. as interval training, and (2) several training sessions over a longer training period induce changes in miRNAs-expression and whether (3) these changes in miRNAs play a physiological role by which walking training positively influences whole-body metabolism in patients with peripheral arterial occlusive disease and favours disease progression of recovery.