Pharmacodynamic, pharmacokinetic, and pharmacogenomic studies
The pharmacodynamic, pharmacokinetic, and pharmacogenomic studies of the antithrombotic agents will be performed in qualified centers for consented participants. The pharmacodynamic study of the antiplatelet drugs will be performed by light transmission aggregometry (LTA). In detail, 2 mL venous blood will be separately collected into two 3.2% sodium citrate vacutainer tubes (Becton, Dickinson and Company) at 7:30 a.m. on the day of discharge. Then blood samples will be subjected to an LTA test within 2 h, as previously described.