Interpretation
hyperglycaemia
HYPERGLYCAEMIA, TYPE 2 DIABETES
In the HAPO FUS, significant associations between maternal and offspring glucose levels were detected, which were suggested by the authors to be clinically important, possibly contributing to the increasing prevalence of type 2 diabetes in children (The HAPO FUS observed the strongest associations between maternal and offspring fasting glucose, and maternal and offspring 2-hour glucose. The authors argued that this suggested that hereditary factors, not captured by family history, contributed to the associations (The children in our study were examined at ~9 years of age. There are indications that associations between maternal and offspring glucose metabolism might be more evident in older children. Most studies detecting significant associations have examined children older than in the current study (When evaluating the relationship between maternal and offspring glucose metabolism it is relevant to assess whether an association is mediated by the Previous literature does not provide clear evidence on how maternal BMI affects the relationship between maternal and offspring glucose metabolism. BMI is an established risk factor for hyperglycaemia in pregnancy (In the current study, adjustments were also performed for selected additional covariates. Gestational age at the time of the OGTT was included as a covariate because of the known physiological changes in glucose metabolism over the course of pregnancy (Other studies investigating associations between maternal and offspring glucose metabolism are generally less comprehensively adjusted than the present study, missing adjustments for hereditary and/or lifestyle confounding factors (