Introduction
SS, pSS, autoimmune chronic disease, Sjogren’s syndrome, dryness of mouth, exocrine glandular dysfunction
INFILTRATION, AUTOIMMUNE DISEASE
Sjogren’s syndrome (SS) is a systemic autoimmune chronic disease characterized by marked exocrine glandular dysfunction such as salivary and lachrymal glands, presenting a persistent dryness of mouth and eyespSS has a very heterogeneous clinical presentations and the etiology has not been fully elucidated. Infiltration of a large number of lymphocytes and expression of various cytokines in the exocrine glands were detected in animal modelsIn recent decades, a wide range of animal and clinic-based methods have emerged as novel therapeutic methods, with evidence showing that the transplantation of ADSCs may benefit in treating autoimmune diseaseAccording to our literature research, although many in vitro and in vivo studies have investigated the effects of ADSCs on exocrine gland function and autoimmune disease, to date, the effectiveness of ADSCs for patients with pSS in a clinical setting remains inadequate and inconclusive. With this background, the main objective of this trial is to evaluate the safety and potential efficacy of ADSCs on pSS patients, by assessing subjective symptoms, clinical and laboratory outcomes.