Event accrual patterns
nonfatal stroke, death, cardiovascular death, stroke, unstable angina, nonfatal myocardial infarction
MYOCARDIAL INFARCTION, STROKE, EVENT, UNSTABLE ANGINA, EVENTS, HEART FAILURE
The total adjudication time is shown in Table Adjudication time windowsMACE-4: 4-point major adverse cardiovascular event comprising nonfatal myocardial infarction, nonfatal stroke, cardiovascular death, or hospitalization for unstable angina; MI: myocardial infarctionDays within phases of event accrual and adjudication are shown as median (25th, 75th percentiles). Total adjudication time includes the time between when the event occurred and when a final adjudication decision was renderedMeasuring the adjudication gap. The temporal gap between event occurrence and event accrual (event recorded after completion of adjudication) is shown. The blue line shows the cumulative number of events of all-cause death, stroke, myocardial infarction, hospitalization for heart failure, and hospitalization for unstable angina by event date. The red line shows cumulative event numbers by adjudication date. The dashed line shows the median time for event adjudication. The space between the red and blue lines is the “adjudication gap,” which can be interpreted as the amount of time between the occurrence of events in real time and the lag time taken to complete adjudication (horizontal arrow) or the difference in number of reported and adjudicated events at a given time point (vertical arrow). The area between the blue and dashed lines represents events requiring less than the median time for adjudication, and the area between the dashed and red lines represents those requiring longer than the median time