Discussion
fatigue, muscle fatiguability
The main objective of this study was to determine if a-tDCS targeting the left M1 could modulate maximal force production or muscle fatiguability in either the right (contralateral to tDCS) or left (ipsilateral to tDCS) quadriceps. This study demonstrated significant force impairments (s-tDCS with testing of contralateral KE MVC, and a-tDCS with testing of ipsilateral KE MVC) and no significant changes (a-tDCS with testing of the contralateral KE MVC and s-tDCS with testing of the ipsilateral KE MVC) in discrete (single repetition) MVC tests.Since four meta-analyses [The anodal and sham tDCS post-test protocols were conducted after approximately 10 minutes of physical inactivity. While the pre-test MVCs were performed shortly after a warm-up, the beneficial effects of this warm-up may have been reduced after 10 minutes of inactivity [While a-tDCS in the literature has shown the ability to increase M1 excitability, it has also been hypothesized that a-tDCS could attenuate the reduction in output from the M1 contributing to supraspinal fatigue [This study found no significant differences between male and female participants for relative force production or fatigue index. This suggests that tDCS affects male and female participants to a similar extent. A review by Dedoncker [