Subjects
DISEASES, MUSCULOSKELETAL DISORDERS
Eligibility criteria included being between 18 and 65 years of age with no (medical or psychosocial) contraindication against vigorous exercise. Exclusion criteria were absolute and relative contraindications for CPET as well as intake of psychoactive substances, renal, neurological, or mental diseases, musculoskeletal disorders or any acute injury, according to current recommendationsSubjects underwent a baseline examination consisting of medical history, physical examination, routine laboratory tests, electrocardiogram, a pulmonary function test, and an initial CPET to determine individual load levels (see module 2).Sample size calculation (G*Power Ver. 3.9.1, level of alpha = 0.05, power = 0.80) based on different cardiopulmonary parameters (e.g., minute ventilation (VE), heart rate (HR), blood oxygen saturation (sO