Introduction
colorectal cancer, tumor, ’, cancer, Colorectal cancer
METASTATIC COLORECTAL CANCER, COLORECTAL CANCER, TUMOR, CANCER, COLORECTAL CANCER
Patients with metastatic or unresectable colorectal cancer have limited options for cancer directed treatment [One approach to the individual selection of drugs is in vitro sensitivity testing of patient-derived tumor organoids (TDOs). Colorectal cancer cells expanded in three-dimensional (3D) cultures retain their molecular subtype and are amenable to high-throughput drug screens [In the present trial, we assessed metastatic colorectal cancer patients’ feasibility and clinical outcome using individualized in vitro tumor response tests. The patients with no satisfactory treatment options underwent biopsies of the metastatic site to generate TDOs. Next, sensitivity testing assays were performed in those TDOs using selected drug panels. Based on these results, an individualized anti-cancer treatment was conducted. Herein, we report the clinical results of patients allocated to precision treatment, the precision cohort.