Author contributions
HL
DNA DAMAGE
DP, MS, DS provided clinical management of patients on the trial and helped write the manuscript. FG did the exosome and HER2-3 dimer analyses and helped write the manuscript. JH, VS, HL did the analysis of DNA damage and repair by the Comet assay and helped write the manuscript. LH did the pharmacokinetic analysis. TN supervised the exosome and HER2-3 dimer analysis and helped write the manuscript. PB, GW did the HER2-3 dimer analysis and helped write the manuscript. SP, LW, SLF provided central coordination for the trial and helped write the manuscript. AL provided statistical support for the trial and helped write the manuscript. DH designed the trial, provided clinical management of patients on the trial and helped write the manuscript.