4.2 Fatty acid metabolism
kidney-qi
The concentration of fatty acids in the follicular microenvironment or oocyte culture medium is associated with quality and development during A total of 31 metabolites were significantly changed in the treatment group compared with the placebo group after conditioning with kidney-invigorating herbs, including 3 up-regulated and 28 down-regulated metabolites. A total of 20 metabolic pathways were found to be significantly changed by KEGG pathway analysis. After comprehensive comparison of the differential metabolites among the three groups, we found that the nine metabolites, L-aspartate, glycine, L-serine, palmitoleic acid, palmitate, alanine, γ-linolenic acid, α-linolenic acid, and N-acetyltryptophan, were the most correlated, and they all had one property: Guilu Erxian Ointment, a kidney-invigorating Chinese medicine, changed from the original up-regulation to down-regulation after intervention. Combined with previous studies and this differential metabolite profile, we found that the two metabolic pathways of amino acid metabolism and fatty acids were mainly related to the mechanism by which kidney-invigorating herbs improved IVF outcomes in older patients with poor ovarian response of kidney-qi deficiency type.