Methods
Deaths
REGRESSION
The methods of the randomized double-blind LOVIT trial have been described in other papers [Deaths in the LOVIT trial over the first 11 days.Vitamin C was administered for 4 days, thus, from day 5 forward, the vitamin C group did not get additional vitamin C. See the We used Cox regression to estimate the mortality rate in the vitamin C group compared with the placebo group, using the Improvement of the Cox model by allowing two separate vitamin C effects in the LOVIT trial.The improvement in the Cox regression model over the reference model (uniform effect) was tested by the likelihood ratio test. The reference model estimates that vitamin C decreased mortality uniformly over the 11 days by RR = 1.32 (95% CI 0.99–1.76; 