Author contributions
DRD
DRD, SN, DJS, SP, SK, and DC designed the experiments. DRD, SP, DJS, and SN wrote the research plan and the animal protocols for the studies. DC and SK performed EDC culture in the cell manufacturing facility. RV analyzed the miRNA data. YR performed the proteomic studies and analyzed the data. SP, CN, and PK were responsible for the generation and analysis of in vitro study data. SP and DRD performed the animal studies. SP, CN, PK, and DRD analyzed the data. SP, RV, YR, and DRD cowrote the manuscript. All authors reviewed and approved the final version of the manuscript.