Definition of successful hemostasis and endpoints
blood loss, bleeding
BLOOD LOSS, BLEEDING, SECONDARY
For the clinical application of the hemostatic agents, successful hemostasis was achieved when there was cessation of visible bleeding after completion of the hemostatic agent administration.The primary end points were the proportion of patients with complete hemostasis within 5 min for the aortocoronary anastomosis sites treated with GHM or CHM and the proportion of patients with complete hemostasis evaluated at 1, 2, and every minute up to 5 min. The secondary end points were the time required for hemostasis, the amount of blood loss on the operative day, the amount of blood products transfused both intraoperatively and postoperatively, the surgical revision rate for bleeding, the total length of intensive care unit (ICU) stay, and the rate of postoperative morbidity/ mortality. All patients were followed during their hospital stay by the same member of the surgical team, who filled out a protocol for pre- and postoperative data comparison.