Introduction
schizophrenia spectrum disorders, illness, psychosis
DISORDER
Clinical insight, which is defined as being aware of having a mental disorder and having the ability to recognise symptoms of the disorder and the need for treatment [Antipsychotic drug therapy is a cornerstone in the treatment of schizophrenia spectrum disorders [The stage of illness may influence the level of insight [The present study reports results from the BeSt InTro trial, a pragmatic, semi-randomised, rater-blinded, head-to-head comparison between three first-line atypical antipsychotics: amisulpride, aripiprazole and olanzapine [The aim of this study was to examine the longitudinal effectiveness of amisulpride, aripiprazole and olanzapine on insight and whether these possible effects were over and above the effect of an overall reduction in psychosis symptoms. Based on the EUFEST study, we hypothesised that there will be differences among the three study drugs regarding their impact on insight. In addition, some will have an added effect beyond a change in psychosis symptoms. Furthermore, we anticipated that antipsychotic-naïve patients would experience a stronger effect on insight independent of the type of antipsychotic that was used.