Background
cancer, prostate cancer
CANCER, PROSTATE CANCER
Globally, prostate cancer represents a significant health burden for the male population, being the second most commonly diagnosed cancer and the fifth leading cause of cancer-related mortality among men in 2020 [In the hypothalamic–pituitary axis, the hypothalamus secretes gonadotropin-releasing hormone (GnRH), which stimulates the release of pituitary luteinizing hormone (LH) and follicle-stimulating hormone (FSH). LH, in turn, stimulates testosterone production [An alternative option of ADT is the suppression of sex hormones by GnRH antagonists [SHR7280 is a novel oral small molecular GnRH antagonist that selectively blocks the binding between endogenous GnRH and its receptor, inhibiting the synthesis and release of gonadotropins like LH and FSH, and reducing the levels of testosterone and E