Statistical analysis
SE, infection, co-infections, CRF
INFECTION, HAND INFECTION, CRF, SCHISTOSOMIASIS
Data were first recorded in paper-based case report forms (CRF) and then entered on KoBoToolbox for data analysis, with cross-checks by a second investigator to minimize data transfer errors. Data saved in the KoBoToolbox system were exported into Microsoft Office Excel, and checked for errors, missing values, and extreme values. The cleaned data were exported to Stata SE version 17.0 (Stata Corp; college Station, TX, USA) for statistical analysis. The raw data and the codes to the raw data are included as supplementary information for further studies and systematic review (Using data from prevalence survey participants, prevalence of STHs with 95% confidence intervals were calculated. The arithmetic mean eggs count was obtained from the microscopic examination of the Kato-Katz method. The intensity of infection was categorised by the criteria of WHO guideline [Baseline characteristics including sex, age, anthropometric indicators, co-infections with schistosomiasis, and infection intensity were displayed stratified by each of the four randomization groups. The primary analysis of trial outcomes was done as an “at the margin analysis” [CR was calculated as the percentage of infected individuals at prevalence survey that are free of infection three weeks after treatment. ERR was calculated as the difference in the mean eggs per gram before and after the treatment, expressed as a percentage of the mean eggs per gram (EPG) before treatment [Difference in cure rates between trial arms were assessed using chi-squared tests, and quantified as odds ratios and 95% confidence intervals using Mantel-Haenszel method. Bootstrap re-sampling methods with 1,000 iterations were used to calculate confidence intervals for ERR and the treatment group differences, with differences considered significant when 95% confidence intervals of treatment efficacy excluded the null value. 