Clinical response rate
T790M-positive
CNS METASTASES
Response evaluation was available from 1322 patients; of them, 736 patients (55.7%) had an investigator-assessed best overall response as “responding” (95% CI 52.9–58.4). The response rate in patients with T790M-positive status by tissue testing and plasma testing was 60.4% (95% CI 56.9–63.9) and 48.9% (95% CI 44.6–53.2), respectively. The response rate in patients with and without CNS metastases was 58.2% (95% CI 52.7–63.6) and 57.9% (95% CI 53.0–62.6).