Ethical consideration and study design
WSLs lesions, WSLs
This study was a parallel randomized, three arm, clinical trial conducted in the Pediatric Dentistry clinic of the Faculty of Dentistry, Alexandria University. Ethical approval was obtained from the Research Ethics Committee, Faculty of Dentistry, Alexandria University (#0086–11/2019). The trial was prospectively registered on the clinicaltrials.gov registry (NCT04929509). Before the intervention, the study was explained to the participants and they were informed about the etiology of WSLs and the available options for treatment. They were also advised about the importance of oral hygiene and proper diet in preventing WSLs lesions.