Abstract
non‐T2D‐HIIT, inflammation, CAD, T2D
INFLAMMATION, SECONDARY, TYPE 2 DIABETES, CORONARY ARTERY DISEASE, CAD
Low‐grade inflammation is central to coronary artery disease (CAD) and type 2 diabetes (T2D) and is reduced by exercise training. The objective of this study was to compare the anti‐inflammatory potential of moderate‐to‐vigorous intensity continuous training (MICT) and high‐intensity interval training (HIIT) in patients with CAD with or without T2D. The design and setting of this study is based on a secondary analysis of registered randomized clinical trial NCT02765568. Male patients with CAD were randomly assigned to either MICT or HIIT, with subgroups divided according to T2D status (non‐T2D‐HIIT We compared the efficacy of high intensity interval training (HIIT) and moderate intensity continuous training (MICT) in improving low‐grade inflammation in patients with coronary artery disease (CAD) with or without type 2 diabetes (T2D). We observe and report that HIIT and MICT were similarly effective in decreasing the levels of the circulating inflammatory markers in both patients with CAD and patients with CAD and T2D. Furthermore, the training interventions showed a greater effect in the reduction of fibroblast‐growth factor 21 (FGF21) and interleukin‐6 (IL‐6) in patients with CAD and T2D than in patients with CAD alone.
