By Treatment Modality: Antidepressant Therapy
depression
REMISSION
Among the 45 participants who received ADT, 43 (95.6%) were prescribed fluoxetine and 2 (4.4%) received imipramine; only one woman had a dosage increase of her medication. At this point in the ongoing study, mean number of months of ADT is 9.3 (SD = 4.8; range: 2 weeks to 25 months). Thirty-three women (73.3%) responded to ADT after a mean of 19.2 weeks (SD = 14.0), and the mean PHQ-9 at the conclusion of either treatment or study participation was 1.9 (SD = 2.0).Among the 33 participants who responded to ADT,13 (39.4%) experienced worsening of their depression after initial response, including three who began receiving PST in addition to ADT. Among these 13, 10 (78.6%) (including the three who received augmentative PST) had their depression return to a state of remission at the end of treatment or the study. Therefore, 30 (66.7%) participants responded to ADT overall.Of the 12 (26.7%) whose depression never responded to ADT, 4 prematurely discontinued treatment, 3 added PST (two of which then responded to treatment), and 1 was switched to PST from ADT.