Statistical analysis
The methods of statistical analysis were described previously [All test statistics used in the analyses were the results of two-sided tests with a significance level of 5%. Data are reported as number (percentage), mean ± standard deviation, median (interquartile range), or estimated value with 95% CI as appropriate. Normality was assessed by inspecting histograms. All statistical analyses were performed using SAS 9.4 (SAS Institute Inc., Cary, NC, USA) and Stata/MP 17.0 (StataCorp., College Station, TX, USA).