Patient eligibility
ONCOLOGY, SOLID TUMORS
Patients were eligible for enrollment based on the following criteria: 1) 18 to 65 years of age; 2) histologically or cytologically diagnosed with advanced malignant solid tumors; 3) failure of routine therapy or without conventional standard therapy; 4) Eastern Cooperative Oncology Group Performance Status (ECOG PS) 0–1; 5) life expectancy of > 3 months; 6) adequate or acceptable organ and bone marrow function. The patients were excluded if they had received prior or current treatment with PI3K or mTOR inhibitors.