Statistical Analysis
According to the retrospective data from our center, the R0 resection rate for BR-ESCC with surgery alone was approximately 20% (3/12) and expected to increase to 40%. With a one-sided alpha significance level of 0.05 and a statistical power of 80%, the inclusion of 40 patients was required for evaluation of the R0 resection rate. In addition, assuming a dropout rate of 15%, at least 46 cases needed to be enrolled. The 95% CI for the R0 resection rate was calculated based on the binomial distribution.Both OS and DFS were estimated using the Kaplan-Meier method, and a log-rank test was used for comparisons between the groups. In addition to comparing survival between the surgery and non-surgery patients, we divided the patients into two groups based on whether they underwent R0 resection. The patients in the R0 group included those who underwent R0 operation. The patients in non-R0 group comprised two types of patients: those who did not undergo surgery (The chi-square test or Fisher’s exact test and Student’s 