Why was this study done?
PATHOGENESIS, POLYMYALGIA RHEUMATICA (PMR), INFLAMMATORY DISEASE, PMR
Polymyalgia rheumatica (PMR) is a common inflammatory disease in elderly persons whose pathogenesis is not elucidated. Glucocorticoids are the first-line drugs for patients with PMR but result in numerous side effects. New therapeutic agents are urgently needed.We investigated whether Janus tyrosine kinase (JAK) signaling was involved in the pathogenesis of PMR and if JAK-inhibitor tofacitinib was effective in the treatment of patients with PMR.