What this study adds
The structured medication review intervention based on an electronic clinical decision support system led to the implementation of certain prescribing recommendationsHowever, the findings as to whether the intervention led to a greater appropriateness of patients’ prescriptions overall were inconclusiveWe thank the general practitioners who participated in the OPTICA trial for their contributions, without which conducting this study would have been impossible. We also thank the participants for consenting to participate in our study. We thank Sophie Mantelli, Axel Löwe, Fanny Lindemann, Jeanne Moor, Heinz Bhend, and Lamia Elloumi for their support with the conduct of the OPTICA trial; Shana Bertato, Rebekah Hoeks, Dominic Salvisberg, Renata Lüthold, Yasmin Mohd Yatim, Melisa Harmanci, and Linda Chau for their support with the data entry; and Kristie Weir for her editorial suggestions. KTJ is a member of the Junior Investigator Intensive Program of the US Deprescribing Research Network, which is funded by the National Institute on Ageing.Extra material supplied by authorsWeb appendix: Supplementary materialsContributors: NR, SS, MSchwenkglenks, ST, MS, CS, and KTJ designed the trial. KTJ, AKA, CF, ZR, RM, NS, FV, MB, ST, MSpruit, MSchwenkglenks, NR, and SS contributed to the acquisition, analysis, and interpretation of data. KTJ and OS wrote the first draft of the manuscript. All other authors provided feedback and approved the final version of the manuscript. OS, AL, and ST provided statistical support and did the statistical analyses. NR, MSchwenkglenks, and SS obtained the funding for the OPTICA trial. NS and FV provided administrative and technical support. NR and SS supervised the conduct of the trial. KTJ and OS had full access to all the data in the study and are the guarantors. The corresponding author attests that all listed authors meet authorship criteria and that no others meeting the criteria have been omitted.Funding: The OPTICA trial was funded by the Swiss National Science Foundation, within the framework of the National Research Programme 74 “Smarter Health Care” (NRP74) under contract number 407440_167465 (to SS, NR, and MSchwenkglenks). The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.Competing interests: All authors have completed the ICMJE uniform disclosure form at The lead authors (the manuscript’s guarantors) affirm that the manuscript is an honest, accurate, and transparent account of the study being reported; that no important aspects of the study have been omitted; and that any discrepancies from the study as originally planned (and, if relevant, registered) have been explained.Dissemination to participants and related patient and public communities: The results of the OPTICA trial were presented at a national press conference in January 2023. The results of the OPTICA trial will be published in German and French in a journal that is commonly read by Swiss general practitioners. The submission of this article is planned for 2023. A lay summary of the OPTICA trial in German, French, and English can be found on the website of the NRP74 (Provenance and peer review: Not commissioned; externally peer reviewed.