Methods
cancer, bleeding, diabetes
OCCLUSIVE ARTERIAL DISEASE, BLEEDING, CANCER, EVENTS, DIABETES
The ASCEND 2 × 2 factorial randomized trial, in 15,480 people with diabetes but no occlusive arterial disease, investigated the effects of 6–10 years of aspirin 100 mg once daily versus placebo tablets and omega-3 fatty acids 1 g once daily versus placebo capsules on cardiovascular events, cancer, and bleeding (protocol and CONSORT diagram [A random subgroup of 152 participants (balanced by treatment allocation) with urine samples at both baseline and follow-up was selected for the U-TXM assay. This was estimated conservatively to give 95% confidence limits (CIs) of about ± 10% or less around an anticipated 60–70% reduction in U-TXM in aspirin versus placebo-allocated participants (