Safety of the trial
TdES, abnormalities, nasal abnormalities, inflammation, keratitis, dermatitis
INFLAMMATION, KERATITIS, OPACITIES, DERMATITIS, INTRAOCULAR PRESSURE
The incidence of AEs (type, frequency, and severity) at 12 weeks was confirmed. No AEs occurred during the study. Similar to our previous results with TdES, abnormalities such as keratitis, dermatitis around the skin electrodes, inflammation of the anterior ocular segment, opacities of the optic media, abnormalities of the fundus and facial and trigeminal nerves, and nasal abnormalities were not observed. There were no significant differences in the intraocular pressure between the baseline and final visit values. The TdES was completed in all five cases, and there was no problem with tolerability to electrical stimulation.