Immune and interferon-related respiratory diseases
lung inflammation, viral respiratory disease, pneumonia, death, MERS, Respiratory disease, VRD, leprosy, bronchitis, Pneumonia, Dementia, Bronchitis, COPD
LUNG INFLAMMATION, VIRUS, PNEUMONIA, DISEASE, RESPIRATORY DISEASE, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, INFLUENZA A, LEPROSY, BRONCHITIS, COPD, PNEUMONIA, BRONCHITIS, DISEASES, INFLAMMATORY DISEASE
T1 (T1 (T2 (The T2 (T2:T3 and T2:T4 can explain no prevalence during the pandemic period of SARS-CoV (2002), influenza A virus subtypes H1N1 (2009), MERS (2015), and SARS-CoV-2 (2020) on Sorok Island. In addition, the T1:T3, T1:T4, T2:T3, and T2:T4 tests indicate that as of 2010, the group with dapsone (+) and the group without dapsone (−) were separated, and the group taking dapsone should have milder symptoms of VRD. SARS-CoV-2 as RNA-virus activates cGAS– stimulator of interferon genes (STING) signaling in endothelial cells through mitochondrial DNA release, which leads to type I IFN production, and pharmacological inhibition of STING reduces severe lung inflammation and disease severity (Domizio et al. Study for T1, T2, T3, and T4. T1 group is dapsone prescribed with VRD-diagnosed subjects, T2 group is dapsone unprescribed with VRD-diagnosed subjects, T3 group is dapsone prescribed with VRD-undiagnosed subjects, and T4 group is dapsone unprescribed with VRD-undiagnosed subjects. After the Dementia Management Act was enacted in 2010, it became clear whether dapsone was prescribed because leprosy patients at Sorok Island should visit Sorokdo National Hospital to receive treatment. The column chart for the T test—changes started in 2010, and the VRD patterns are apparent in T1, T2, T3, and T4 from 2005 to 2019. The proportion of T2 patients without dapsone and with VRD increased significantly. T2:T3 graph shows that HD patients with prescribed dapsone have a very low prevalence of VRD. T1:T3 and T1:T4 demonstrate that VRD (+/−) groups in the dapsone (+) are distinguished as 2010. Furthermore, trend lines (We explored interferon-related diseases and classified those as (1) immune-related inflammatory diseases, (2) bronchitis, (3) bacteria-origin pneumonia, and (4) chronic obstructive pulmonary disease (COPD) from Tables Respiratory disease (RD) prevalence on Sorok IslandImmune-related inflammatory diseases showed a sharp increase in prevalence from 2008 to 2015, followed by a decrease. COPD increased slowly from 2008 to 2011, rapidly increased in 2012 and 2013, and decreased. Bronchitis levels rose rapidly from 2012 to 2014 and then decreased. Pneumonia increased sharply in 2013 compared to previous years.
Since 2008, immune-related inflammatory diseases have increased rapidly. It is a period of viral respiratory disease: 2008–2010 endemic on Sorok Island. Since 2012, COPD has increased, as have bronchitis and pneumonia frequencies. We observed a decrease in the average age of death in the group taking AAD and psychotropic drugs from 2008 to 2015 (Lee 