2.3. Intervention
Randomization was performed individually using a web-based interactive response system. Addpharma Co., Ltd. prepared the investigational drugs according to the randomization list. The investigational drugs (4 pills once a day: one actual medication and 3 placeboes) were prescribed for 8 weeks. The patients and researchers were blinded to the trial-group assignments, and therapeutic lifestyle changes were encouraged throughout the study period.