1. Introduction
Obesity, obesity, inflammation, overweight, overweight or obesity
OBESITY, OBESITY, INFLAMMATION, MALNUTRITION, PATHOGENESIS
Current address: Precision Nutrition and Cardiometabolic Health, IMDEA Food Institute, CEI UAM+CSIC, 28049 Madrid, Spain.Background and aims: Obesity is a public health problem. The usual treatment is a reduction in calorie intake and an increase in energy expenditure, but not all individuals respond equally to these treatments. Epigenetics could be a factor that contributes to this heterogeneity. The aim of this research was to determine the association between DNA methylation at baseline and the percentage of BMI loss (%BMIL) after two dietary interventions, in order to design a prediction model to evaluate %BMIL based on methylation data. Methods and Results: Spanish participants with overweight or obesity (Obesity is considered one of the main factors of morbidity due to malnutrition, and it is observed how incidences increase over the years. Obesity and overweight are defined as an excessive or abnormal accumulation of fat that can be detrimental to health. It is classified by body mass index (BMI). It is determined as overweight when presenting a BMI of 25 to 29.9 kg/mThe pathogenesis of obesity is due to a metabolic condition of disturbed adipocyte function and low-grade systemic inflammation, and this can induce epigenetic changes that perpetuate inflammation [