Author contributions
S.A.H.
S.A.H. and M.L.N. designed the study, acquired funding, carried out the perfusion techniques and project administration, collected the data and wrote and reviewed the manuscript. L.S. assisted in the design of the study, provided the statistical plan, analyzed and validated the data and co-wrote, reviewed and edited the manuscript. J. Mullings and J. Mehew analyzed and validated the data. C.J.C. and C.H.W. assisted in the design of the study, carried out the perfusion techniques, collected data and reviewed and edited the manuscript. G.C.O., B.L.P. and L.B. carried out the perfusion techniques, collected data and reviewed and edited the manuscript. L.S. and J. Mullings directly accessed and verified the underlying data.