Keywords
SAKK, node-negative
SENTINEL LYMPH NODE, NODE-POSITIVE BREAST CANCER
Open access funding provided by University of BaselAxillary surgery has changed remarkably over the last decades. In the 1990s, the sentinel lymph node (SLN) procedure replaced standard axillary lymph node dissection (ALND) as the staging procedure in clinically node-negative patients.In the ongoing, international, multicenter phase III OPBC-03/TAXIS trial (SAKK 23/16 / IBCSG 57-18 / ABCSG-53 / GBG 101; ClinicalTrials.gov identifier: NCT03513614), patients with clinically node-positive breast cancer undergo tailored axillary surgery (TAS) before being randomized to receive ALND or axillary radiotherapy (ART) in the setting of extended regional nodal irradiation.