Intervention
CDA, COLD
As part of the standard of care, all livers were preserved by static cold storage following classic organ procurement. All liver grafts were flushed with 1 L of Institut Georges Lopez (IGL-1) preservation solution through the portal vein ex situ at the end of the back-table preparation at the recipient center. All transplants were done with caval replacement using venovenous bypass. After completion of caval and portal anastomosis, reperfusion of the liver was initiated. The standard of care further included an immunosuppressive regimen consisting of tacrolimus (trough levels between 5 and 8 μg/L), mycophenolate mofetil (500 mg, 2 times), and steroids (tapered to 3 months).In addition to standard of care, patients in the CDA group received a combination drug regimen that was adapted from the CDA regimen used in the porcine study.