Changes in lipoprotein profiles after 5 days of high-fat diet
Supplementary Table Scores and loading plots from multilevel partial least squares discriminant analyses for discriminating lipoprotein profiles at baseline (habitual diet) from those after 5 days of high-fat diet. (The classification models separated samples from before to after 5 days of HFD with high classification accuracy (79% and 100% accuracy for fasting and postprandial samples, respectively). In the fasting samples, increased concentrations of several LDL-related variables and decreased concentrations of VLDL- and HDL-related variables were evident after HFD. The postprandial samples showed some deviations from the fasting samples, with reduced concentrations of variables related to LDL-5 and increased concentrations of several HDL-related variables (Fig. Change in lipoprotein subfractions from baseline to after 5 days of high-fat diet. In (The HFD increased total fasting serum LDL cholesterol concentration, due to increased cholesterol in larger LDL particles, with significant increases in LDL-2 and LDL-3 (Fig. Cholesterol and Apolipoprotein-B100 (Apo-B) in LDL measured in the fasted state. Data from participants (In the postprandial samples, total serum concentrations of cholesterol and Apo-A1 increased after the HFD (Supplementary Table When comparing the effect of continued HFD from 5 days (at Visit 2) to 11 days (Visit 3) we observed a decreased PC1 score at the last assessment (Fig. Changes after continued high-fat diet with and without exercise training. Scores and loading plots from repeated measures ANOVA simultaneous component analysis for discriminating lipoprotein profiles after exercise/no exercise for 5 days (Visit 3) from after 5 days of high-fat diet (Visit 2), in the fasted state. (Despite no further elevation of total serum LDL cholesterol, cholesterol concentration in the larger LDLs (LDL-1–4) increased, while it decreased in the smaller LDLs (LDL-5–6) after continued HFD. Most of the HDL-related variables increased, except for triglycerides which decreased in all subfractions (Supplementary Table 