4. Discussion
sore throat, cold-like, febrile
SORE THROAT, COMMON COLD
We evaluated the effect of MCC1849 on subjective symptoms of physical condition in both sexes over a wide age range in this study. The results showed significantly fewer days with a stuffy nose and shorter durations of stuffy nose and sore throat in the MCC1849 group (We assessed each subjective symptom in addition to cold-like symptoms for detailed analyses. Furthermore, the duration and number of times of onset were calculated as well as the number of days and incidence. The efficacy of MCC1849 was consistent with a previous study [The MCC1849 group had significantly fewer days of stuffy nose and shorter durations of stuffy nose and sore throat (We assessed body temperature as an objective measure of physical condition. The febrile state is defined as a temperature above 37.5 °C in Japan. No significant differences were found between groups in the effects of MCC1849 on body temperature above 37.5 °C (Since the incidence of the common cold increases in the winter, this study was conducted from winter to spring [There were no side effects associated with the intake of test food for 24 weeks. A previous study similarly demonstrated the safety of MCC1849 [There were some limitations to this study. The participants were all healthy adults, so the effect of MCC1849 on children or sick individuals is unknown. Moreover, we did not measure immune parameters. Further studies evaluating the effects on subjective symptoms and immune parameters in the same study may elucidate the detailed mechanism of MCC1849.