Ethics approval
This study was approved by the Clinical Research Ethics Committee of the Second Affiliated Hospital of Hainan Medical University, Haikou, China (approval number LW202101, approval date January 4, 2021). The trial was registered at the Chinese Clinical Trial Registry (ChiCTR2100052425, principal investigator: Song Lyu, registration date: October 26, 2021). Written informed consent was obtained from all patients who participated in the trial.