Conclusions
migraine, CM
MIGRAINE
The results of this study demonstrated the validity of the WPAI PRO to measure the impact of EM or CM on work productivity (overall and presenteeism) and non-work-related activity impairment. The meaningful change thresholds for the WPAI domain scores may help in evaluating clinically meaningful treatment responses and may be appropriate for inclusion of WPAI in future preventive migraine clinical studies. The analysis was specific to a population with a history of multiple standard-of-care migraine preventive medication failures and moderate frequency EM or greater; however, the meaningful within-patient threshold may be applied to migraine research studies until generalizability of these findings are confirmed.