Estimated Mean Group Differences Between Simvastatin and Placebo and Odds Ratios for the Secondary Outcomes
Depression, Anxiety
DISORDER, REMISSION
Abbreviations: BMI, body mass index; CGI, Clinical Global Impression Scale; GAD-7, 7-item Generalized Anxiety Disorder Scale; HamD-24, 24-item Hamilton Rating Scale for Depression; MADRS, Montgomery-Åsberg Depression Rating Scale; MMAS-4, 4-item Morisky Medication Adherence Scale; NA, not applicable; SMD, standard mean difference.Estimates are odds ratios for MADRS remission and CGI and mean differences for all other measures.In the mediation analysis, plasma CRP, HDL-C, and LDL-C levels were unaffected by treatment and thus showed no evidence of effects of changes in these measures on MADRS scores (eTables 6-8 in 