Comparison with other studies
multimorbidity, adverse drug events
RECURRENCE, ADVERSE DRUG EVENTS
Our null findings are in line with the literature on previous clinical trials testing the effect of medication review interventions on appropriateness of medication in primary care settings. For instance, the PRIMUM trial, which randomised 72 primary care practices and 505 patients with multimorbidity and polypharmacy, did not find an improvement in the MAI after a medication review based on an eCDSS for general practitioners.Our findings are in line with the results of previous multicentre trials evaluating an eCDSS based on the STOPP/START criteria. The SENATOR trial, in which 1536 inpatients were randomised, did not find any evidence for a between group difference in the recurrence of adverse drug events within 14 days of randomisation.The low implementation rate of prescribing recommendations could, in part, account for the negative trial. However, the implementation rate was similar in previous trials. In the SENATOR trial, 15% of the overall recommendations were implemented.