Increased abundance of the administered probiotic species in the treatment arm
constipation
We next aimed to investigate microbiome changes as a function of treatment and response to treatment. We received stool samples from 52 individuals at both the baseline and day 84 timepoints. We carried out shotgun sequencing on these samples in an effort to estimate their microbiome composition as a function of treatment and changes in constipation.We queried if the eight microbial species present in the intervention were detectable at greater abundances in the treatment versus the placebo group at the trial endpoint (Fig. 