Statistical analysis
toxicity, tumor
REGRESSION, SECONDARY, DISEASE CHARACTERISTIC, TUMOR
The Bayesian modified toxicity probability interval method of Ji et al. was used to find the MTD of IT dose of nivolumabFor the secondary objective, the Kaplan–Meier method was used to estimate the distribution of OS from the start of study treatment. Cox proportional hazards regression was used to assess the relationship between OS and various covariates of interest, including but not limited to patient demographics, tumor characteristics and disease characteristics. All statistical tests were performed two-sided, and no adjustment was made for multiple testing.