Patient disposition in SAD and MAD phases of Study 1.
SAD
eMV, Need for endotracheal mechanical ventilation; ITT, intent-to-treat; MAD; multiple-ascending dose; SAD, single-ascending dose. Percentages based on the total number of patients randomized and treated in each treatment group. Patients completed SAD phase through Day 7 visit and completed MAD phase through Day 28 visit. *1 patient randomized but not treated. In Study 2, 8 patients were screened from 4 study sites in Japan. Of these, 7 were randomized and treated (40/20 mg/kg, n = 1; 60/40 mg/kg, n = 3, placebo, n = 3). One eligible patient did not undergo randomization and treatment due to the unavailability of the study drug at the study site (