3.3. cfDNA Concentration as a Biomarker for Atezolizumab Response
The cfDNA concentration of 86 cfDNA samples at C0 and 64 paired C4/EOT samples was measured (At the cut-off value at C0 (8.6 ng/mL), patients with a low cfDNA concentration at C0 had significantly higher DCB rates (32.7% vs. 9.3%; The subgroup with low cfDNA concentrations at C0 had a longer PFS and OS compared with the subgroup with high cfDNA concentrations; however, there was no difference in the PFS and OS according to the dynamic change in the cfDNA concentration from C0 to C4/EOT (