Study design
DISEASES
This multicenter, single (examiner)-blinded, parallel arm randomized controlled clinical trial was conducted at the Section of Periodontics, School of Dentistry, Department of Surgical Specialties, Radiological Science and Public Health of the University of Brescia, within the ASST Spedali Civili di Brescia, Department of Odontostomatology, and at the Research Centre for the Study of Periodontal and Peri-implant Diseases, University of Ferrara. The protocol was reviewed and approved by the Ethics Committee of the University-Hospital of Brescia (CE: 2971) and the Ethics Committee of Area Vasta Emilia Centrale (protocol number: 83/2018/Disp/Unife) and the study conducted in accordance with the ethical principles of the Declaration of Helsinki. The study was registered on Clinical Trials.gov (NCT04264624).