Study design and participants
infection, allergy, intracranial hypertension
CIRCULATORY SHOCK, ALLERGY, INFECTION, ACUTE PANCREATITIS, CENTRAL NERVOUS SYSTEM INFECTION
This pragmatic, multicenter, randomized, controlled, open-label, and parallel group superiority trial enrolled adult patients with a clinical diagnosis of acute pancreatitis upon admission to one the 11 participating intensive care units from France, Switzerland, and Belgium. The diagnosis of acute pancreatitis required two of the following three features, as per the revised Atlanta definition [The trial design has been published previously [Patients fulfilling one or more of the following criteria were not included: prothrombin time < 60%, platelet count < 75 G/L, curative anticoagulant therapy with heparin interrupted for less than 8 h, local infection, active central nervous system infection, history of back surgery associated with a dural space procedure, suspected or confirmed intracranial hypertension, refractory circulatory shock despite appropriate resuscitation, known allergy to clonidine, ropivacaine or sufentanil, treatment with a monoamine oxidase inhibitor in the previous 15 days, age under 18 or under tutelage measures, and absence of coverage by the French health insurance system.