Results
SE, fatigue
ADVERSE EVENTS, REGRESSION
Twelve patients were enrolled in the trial (8 women and 4 men) and all patients completed the trial through the final end point. The median age of patients enrolled in the study was 71.5 years. Median treatment time on maximally tolerated BTX was 6 years (2 – 20 years). All patients tolerated CBD and BTX without any significant adverse events. One patient reported increased well-tolerated stool softness. See the The dataset comprised a total of 1,620,000 video frames across the 9 conditions at 5 time points for the 12 participants. The eyelid closure analysis was found to capture 100% of the recorded eyelid position within the analysis range in every lighting and task condition. Summary statistics of the various outcomes calculated from the analysis can be found in the Results of JRS clinical scale. (According to the LMER model, the application of CBD decreased median eyelid closure duration by 15.8% (−18.35 ms, confidence interval [CI] = −29.37 to −7.32 ms, Our mixed effects regression model estimated that median eyelid closure amplitude was reduced by 19.1% (−1.66 mm, CI = −3.19 to −0.14 mm, There were significant reductions from baseline for the median max eyelid closure velocity in both the CBD and placebo groups. Our model estimates that CBD increased the median eyelid closure velocity by 34.8% (−13.26 mm/ms, CI = −20.93 to −5.58 mm/ms, With respect to the estimated blink parameters, the washout period in this trial design appeared to be sufficient to prevent a carryover effect. The interaction term between treatment and session (time period) was not significant when evaluated in any of the outcomes. Individual The statistical analysis of the JRS results was potentially underpowered given the limited number of data points and showed no statistically significant change from baseline. When looking at median values, however, there was, on average, a 0.5 reduction in severity and frequency from baseline in the treatment groups, suggesting a direction of effect (see The Y axis conveys the estimated average given the change from baseline measure. Standard error (SE) bars for each condition are in color; SE for each treatment group is in Initially, a large series of published surveys to track patient experience were utilized at the same appointment as their eyelid closure analysis. These were filled out by the participants themselves, with data compilation and analysis at the end of the study. Many patients noted that they found the questions confusing, complained of survey fatigue, and were reluctant to answer the surveys fully. These results were not utilized due to incomplete survey completion. Participants were asked at each visit whether they were experiencing side effects. None were reported outside of one patient noting increased stool softness.