Introduction
RP, ischemia, RP [, Systemic sclerosis, fibrosis, pain, microvasculopathy, SSc, Raynaud’s phenomenon, Lipoatrophy
ISCHEMIA, DISEASE, SYSTEMIC SCLEROSIS, FIBROSIS, DIGITAL ULCERS, LIPOATROPHY, INFILTRATED
Systemic sclerosis (SSc) is characterized by the presence of functional and structural microvasculopathy resulting in ischemia that leads to cutaneous and visceral fibrosis. In the hand, this disease is characteristically evidenced by Raynaud’s phenomenon (RP) and fibrosis of the skin, tendons, ligaments, and joints [Zuk et al., described the presence of adipose stem cells (ASCs) in the ADSVF, in 2002 [Granel et al. administered the ADSVF into the hands of 12 patients who predominantly had limited cutaneous SSc with no severe involvement of the internal organs. Subsequently, they reported improvements in pain, frequency and intensity of RP and the healing of digital ulcers that were resistant to conventional treatment. There was also an improvement in strength, movement, Cochin Functional Scale Scores, and a decrease in the digital circumference [Bank et al. infiltrated decanted fat in order to treat RP into the base of the fingers and hands of patients with SSc and obtained extraordinary results in terms of improving pain and RP [Lipoatrophy may develop in patients with SSc due to the loss of adipocytes and defective stem cell function [