4.2. Increase in Tn I Levels
cardiotoxicity
An increase in troponin levels was observed frequently in previous trials of cardioprotective therapy, which was not necessarily associated with early deterioration in LV function, and a clear dose-dependency of anthracyclines was observed. Amelioration of troponin elevation was reported in patients treated with carvedilol and metoprolol [We found that anthracycline-containing chemotherapy increased troponin I, even when low-to-moderate doses of anthracyclines were used in patients with a low risk of cardiotoxicity. In our study, troponin elevation was found in almost 42% of patients and were most common after four cycles of chemotherapy. Previous studies have reported troponin elevations in approximately 25–30% of patients treated with anthracyclines [