Systemic Metformin effects on the periodontium during initial phase of healing
treatment).On, periodontium
INFLAMMATORY RESPONSE
Systemic Metformin has never been used for periodontal treatment management in non-diabetic patients. Therefore, we investigated whether systemic administration of Metformin affected the periodontium and modulated periodontal responses during acute healing phase (initial week post treatment).On the day of periodontal treatment, participants undergoing non-surgical periodontal therapy had their chronic inflammatory granulation tissues collected for bulk RNAseq analysis (Fig. The effect of Metformin on the periodontium before and after treatment. Following periodontal treatment, the gingival inflammatory exudate derived from the periodontal tissues was analysed to understand the impact of systemic Metformin treatment on periodontal inflammatory response (Fig. Whilst the effects of systemic admiration of Metformin can be appreciated in the periodontium, it cannot be concluded that these effects are due to the bioavailability of the drug on the local tissues, therefore further research is needed to evaluate the uptake of Metformin in the periodontal tissue. Nevertheless, systemic Metformin administration affected the periodontal tissues modulating immunity, metabolism, and pro- and anti-inflammatory markers during the initial phase of healing.