Authors’ contributions
MR, TTH
TSD
LvS, KT, RJC and MR conceived the idea for this study. LvS, JKB, NJW, NPD, and RNP conceived the IMPROV trial. TSD, KC, NHC, AA, MNN, APP, AGR, IS, NCT, TTH, AH, MAH, LLE, AW and TT were responsible for data collection. KT, RJC, MR and LvS did the data analyses and interpretation and wrote the first draft of the manuscript. All authors critically reviewed the paper and approved the final submitted version for publication.