Study participants: eligibility and consent
malaria, cardiac problems, fainting, allergies
ADVERSE REACTIONS, MALARIA, MINOR, LONG QT SYNDROME, ALLERGIES
All residents in the three study sub-counties were assessed for inclusion in the study. An enumeration and consenting visit was conducted in all three arms prior to study start. In both intervention arms, an additional screening and consenting visit was conducted before each intervention round, to assess continued eligibility for receiving the intervention. Eligibility and exclusion criteria differed slightly by arm. In the SOC arm, all residents were eligible, no screening was needed, written consent was sought for participation in the study, and all consenting participants were enrolled and assigned unique identification numbers. All residents in the IRS and MDA + IRS arms were eligible for IRS, screened for possible adverse reactions to the insecticides, and written consent was obtained from household heads on behalf of the family; all household members of consenting households were assigned unique identification numbers. All household residents in the MDA + IRS arm were additionally screened for MDA intervention eligibility. Exclusion criteria included: younger than 6 months, pregnant, current symptoms of severe malaria, reported allergies to DP, history of cardiac problems or fainting, family history of long QT syndrome, or currently taking medications known to prolong the QT interval (e.g. antiretrovirals). Eligible adults provided written consent for themselves and any minor children, and children between 8 and 18 also provided written assents. Consented participants in this arm were given unique identification cards that included name, geographical location and demographic information as well unique study ID, and requested to present them at the MDA site at time of treatment. After the first round, barcode scanners were used to confirm the identity, consent and screening status of each participant. Prior to each round, eligibility and consent for MDA+IRS was reassessed. At the MDA treatment sites, consents were confirmed and current medical eligibility reconfirmed. Mapping, enumeration, screening, consents, assents, and sample frames were updated prior to each of the four rounds in both intervention arms.