Statistical Analysis
SD
We estimated that with a sample size of 68 individuals, the trial would provide greater than 90% statistical power to detect a significant difference of 0.8% (unit value) in the reduction of IHTG content (SD, 1.0%) between the TRE group and the DCR group at a significance level of .05 using a 2-tailed test. The expected group difference and SD of reduction in IHTG content were based on preliminary data for comparison between the TRE regimen with caloric intake restriction and regular caloric intake (no time restriction).Data were analyzed according to participants’ randomization assignment (intention-to-treat). PROC MIXED of SAS statistical software, version 9.4 (SAS Institute Inc) was used to obtain point estimates and SEs of the treatment effects and to test for differences between treatments. Group differences in the study outcomes were evaluated using the general linear model for continuous variables and the χ