Mediation Effects of Mayo Subscores on IBDQ Domain Scores
The majority of the treatment effect on IBDQ domain scores was mediated by Mayo subscores. For all IBDQ domains, the overall indirect path (i.e., the pathway from treatment to Mayo subscores and then to each IBDQ domain) through Mayo subscores was significant (all For the IBDQ domains of bowel symptoms (21.0%), social function (27.7%), and systemic symptoms (28.4%), the direct paths (owing to factors other than Mayo subscores) were also significant (all 