Conclusion
migraine, headache
MIGRAINE, VASODILATION
Lu AG09222 significantly inhibited PACAP38-induced cephalic vasodilation and reduced concomitant headache in healthy volunteers. These results demonstrate that Lu AG09222 binds to and effectively inhibits PACAP38-mediated physiological responses and indicate Lu AG09222 as a future treatment for migraine and other conditions that would benefit from inhibition of the PACAP signalling cascade.