Ability to detect change
The ability of a score to detect change over time was assessed using data from the measurement periods associated with Visit 1 and Visit 2 in the psychometric analysis population. To investigate the ability of the PIB score to detect change, subjects were grouped according to the PGIC anchor and categorized into ‘Improved’, ‘Stable’, and ‘Worsened’ groups as follows: ‘Improved’ (very much improved, much improved, or a little improved at Visit 2), ‘Stable’ (no change at Visit 2), and ‘Worsened’ (a little worse, much worse, or very much worse at Visit 2). For the Decision Tree score, the same groups were defined using the CGIS anchor instead. For both domains, the frequency and percentage of subjects in each category were summarized, and the mean change scores for each group from Visit 1 to Visit 2 were listed alongside the SD. The mean change scores were compared between the three groups, and one-way ANOVA 