Findings
stroke, cardiovascular disease
STROKE, SECONDARY, CARDIOVASCULAR DISEASE
In this prespecified secondary analysis of outcomes of 32 804 participants in a randomized clinical trial and posttrial up to 23 years later, there was no significant difference in mortality due to cardiovascular disease among the 3 antihypertensive treatment groups. However, there was an increased risk of stroke outcomes for ACE inhibitors compared with diuretics; after accounting for multiple comparisons, this increased risk was no longer significant.