Ethics and funding
The trial was approved by the Sciences and Technology Cross-Schools Research Ethics Committee (SCITEC C-REC) at the University of Sussex and pre-registered with ClinicalTrials.gov: NCT05676658 (09/01/2023). All methods used in this study were in accordance with the tenets of the Declaration of Helsinki, and all participants provided informed consent. The funder (The Ryoichi Sasakawa Young Leaders Fellowship Fund, Tokyo) played no role in the design of the trial, nor collection, analysis and interpretation of the data, along with writing up for publication.