Dosing schedule
Different dose regimens were simulated based on a separate population pharmacokinetic reanalysis of data from a previous study (Dosing schedule of continuous IV infusions of DMT. Doses are expressed for DMT fumarate. A bolus injection was given over 30 s, followed by a saline flush over 15 s. The continuous slow-rate infusion was started 1 min after the beginning of the bolus injection and maintained for 29 min.