Primary and secondary research outcomes
SECONDARY, INSULIN SENSITIVITY
The primary research outcome of this study was peripheral insulin sensitivity upon 2 weeks of clenbuterol versus placebo treatment, expressed as the change in insulin-stimulated glucose disposal in the high-insulin phase over baseline (ΔRd) during the two-step hyperinsulinemic-euglycemic clamp. The secondary research outcome was skeletal muscle GLUT4 translocation, as assessed by means of immunohistochemistry and confocal microscopy.