Author contributions
TB, SAH, MM
SLdH contributed to the study design and the biomarker sample collection and analysis plan, supported the data analysis, participated in data interpretation, and was a major contributor in writing the manuscript. DJS participated in data interpretation and manuscript review. MM contributed to the analysis and interpretation of data and manuscript review. MFP contributed to the analysis and interpretation of data and manuscript review. GLP participated in data interpretation and manuscript review. CL supported the data analysis and participated in data interpretation and manuscript review. AP participated in data interpretation and manuscript review. VL-V contributed to data collection and manuscript review. TB analyzed the data and participated in data interpretation and manuscript review. SAH designed the study, enrolled and treated patients, collected and analyzed data, and was a major contributor in writing the manuscript. All authors read and approved the final manuscript.