1. Introduction
TNF-α, Psoriasis, hyperplasia, hereditary predisposition, Tumor necrosis, psoriasis
INFILTRATION, PSORIASIS, HYPERPLASIA, PROLIFERATION, INFLAMMATION, INFILTRATES, PSORIASIS, TUMOR NECROSIS, INFLAMMATORY SKIN DISEASE, PATHOGENESIS
These authors contributed equally to this work.Psoriasis is a chronic inflammatory skin disease with autoimmune pathological characteristics. Recent research has found a link between psoriasis, inflammation, and gut microbiota dysbiosis, and that probiotics and prebiotics provide benefits to patients. This 12-week open-label, single-center clinical trial evaluated the efficacy of probiotics (Psoriasis is a chronic inflammatory skin disease with a significant hereditary predisposition and autoimmune pathological characteristics [The pathogenesis of psoriasis is characterized by uncontrolled proliferation and dysfunctional differentiation of keratinocytes. Histologically, psoriatic plaques show epidermal hyperplasia overlying inflammatory infiltrates of dermal dendritic cells, macrophages, T cells, and neutrophils. Tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin (IL)-23/IL-17A, and IL-22 are the primary immunological molecules responsible for keratinocyte proliferation, inflammation, and cytokine infiltration in psoriasis [Probiotic supplementation could represent a novel therapeutic strategy in the treatment of gut microbiota dysbiosis in patients with psoriasis, as supplementation has been associated with significant alleviation of psoriasis-like pathogenic characteristics and a reduced proinflammatory status, in both experimental and clinical trials [