Methods for additional analyses (e.g., subgroup analyses) {20b}
fracture, intramedullary nailing
We will evaluate the several subgroups of clinical interest for any differential treatment effects of local gentamicin administration. These groups include (i) Gustillo-Anderson classification, (ii) severity of wound contamination (minimal vs moderate vs severe using the OTA open fracture classification for contamination), (iii) time from injury to surgery (< 24 h vs > 24 h), and (iv) type of definitive fixation (external fixation vs intramedullary nailing). This analysis will be reported descriptively and with confidence intervals, but no significance 