Epigallocatechin-3-gallate administration
SKIN
EGCG (purity ≥ 95% by high performance liquid chromatography) was purchased from HEP Biotech Co., Ltd (Ningbo, Zhejiang, China) and freshly dissolved in 0.9% saline solution. The EGCG concentration escalated from 660 μmol/L, 1320 μmol/L, 1980 μmol/L, 2574 μmol/L. EGCG administration was initiated when Grade 3 RID occurred first time during radiation therapy. The solution was sprayed three times a day at 0.05 mL beyond the whole radiation field until 2 weeks after first day use of EGCG. Skin wrinkles in armpits and chest wall, need to be fully stretched and exposed before spraying. Other preventive and treatment agents such as: deodorants, lotions, creams, perfumes, external preparations are not allowed in the radiation field during radiation therapy.