Author contributions
A.C. contributed to the study design, collecting samples, and writing the main manuscript, V.M.E. contributed to the study design and data analysis, N.M.W. contributed to the data analysis and interpretation, P.A.W. contributed to the collecting samples and recruiting patients into the study, F.M. contributed to the data analysis and writing the main manuscript, I.F.R. contributed to the collecting samples and recruiting patients, R.B. contributed to the study design and revising the final manuscript, P.S. contributed to the study design and data interpretation, F.N. contributed to the supervision of the study and revising the final manuscript, B.P.M.S. contributed to the study design, supervision of the study, revising and approving the final manuscript.