Measurements
sepsis
SEPSIS
We used the following parameters on the first day of ICU admission (i.e., before initiation of specific treatment for sepsis [e.g., PMX-HA and anticoagulants]) for analysis in the derivation cohort: patient demographics (i.e., age and sex), APACHE II score, SOFA score and each component of the SOFA score, WBC count, platelet count, PT-INR, fibrinogen, fibrinogen/fibrin degradation products (FDP) and lactate level. Missing variables were imputed using the random forest method, a nonparametric algorithm that can accommodate nonlinearities and interactions and does not require a particular parametric model to be specified [Patient characteristics in each quintile in order of estimated individual treatment effects, derivation cohortValues represent median (IQR), unless otherwise indicated. Higher treatment effects on 28-day survival are equivalent to higher absolute risk reduction of 28-day mortalityAPACHE II score, Acute Physiology and Chronic Health Enquiry II score; SOFA score, Sequential Organ Failure Assessment score; PT-INR, Prothrombin Time and International Normalized Ratio; FDP, Fibrinogen/Fibrin Degradation Products; PMX-HA, Polymyxin B Hemadsorption*Variables were used for adjusting the causal forest model