Predicting complications
intestinal injuries, CRS, intestinal injury
ADHESION
Given the relatively high incidence for non-access and intestinal injury, we evaluated ways to predict them. While we detected no significant connection between the Adhesion Score in one procedure and the risk for non-access or bowel lesion in the following PIPAC, we noticed that previous CRS with HIPEC and multiple previous abdominal surgeries served as predicting factors.Patients who had already undergone CRS with HIPEC carried a significantly higher risk of a non-access abdomen with an odds ratio (OR) of 5.9 (Number of patients with the respective numbers of previous abdominal surgeries (except PIPAC procedures). The risk for a non-access abdomen or intestinal injury during a PIPAC procedure rises with increasing numbers of abdominal operations. If, throughout this study, only those patients had undergone PIPAC who did not fall into the aforementioned risk groups, we would have observed only nine non-access situations (5.9%) and five intestinal injuries (3.3%). This corresponds to a potential absolute risk reduction of 3.9% (non-access) or 1.9% (intestinal injury) and a potential relative risk reduction of 66.5% (non-access) or 57.0% (intestinal injury).