Ethics approval
HPS
The protocol was approved by the Committee for Patient Protection Ile-de-France II (n°20.12.21.34036 MS1 RIPH 2 HPS) and by the French Data Protection Authorities.The study was also approved by the Scientific and Ethical Committee of Assistance Publique–Hopitaux de Paris (AP-HP) clinical data warehouse (IRB00011591) allowing to retrieve the ED flow data. AP-HP clinical data warehouse initiative ensures patients’ information and consent regarding the approved studies through a transparency portal in accordance with European Regulation on data protection and authorization (number 1980120) from the National Freedom and Informatics Commission.The trial was registered at ClinicalTrials.gov (NCT04756609).