WHAT THIS STUDY ADDS
status epilepticus
STATUS EPILEPTICUS, ADVERSE EVENTS
There has yet to be a study with a positive result or non-inferiority designed RCT, particularly for adult status epilepticus. We herein conducted a multicentre non-inferiority designed RCT, in which adult patients with status epilepticus were randomised into levetiracetam and fosphenytoin groups as a second-line treatment after diazepam. The non-inferiority of levetiracetam to fosphenytoin was confirmed with less serious adverse events in the levetiracetam group.