Schistosomal abnormal metabolic syndromes.
chronic renal anemia, CKD, kidney disease
PORTAL HYPERTENSION, KIDNEY DISEASE, SCHISTOSOMIASIS, DYSFUNCTION, PULMONARY ARTERIAL HYPERTENSION, GLOMERULOPATHY, PULMONARY HYPERTENSION, COMPLICATIONS
Six isolated complications were identified in SAMs. None of them had ever been mentioned in previous classifications. However, these co-occurring complications were not uncommon in advanced schistosomiasis. A median survival rate of SAMs was found among the three clusters. The central nodes of SAMs were CKD and pulmonary hypertension, also known as schistosomiasis-associated pulmonary arterial hypertension (Sch-PAH).CKD could be caused by various reasons, including chronic renal structure and dysfunction. Immune complex-mediated kidney disease was related to host immune responses to the parasite antigens.Glomerulopathy, portal hypertension, and chronic renal anemia may play roles in Sch-PAH.