Procedures
PMDD mood, PDI, DSM-IV-TR, alcohol abuse
For inferential tests of H1 and H2, we used a 2 × 2, within subjects/repeated measures Analyses of Variance to compare the effects of PAI vs. PDI on PMDD mood, 6-SMT timing, and sleep measures, before and after interventions. For H3, we evaluated the relationships of changes in mood and sleep to changes in 6-SMT timing using Pearson correlations.We received 688 calls from women interested in participating. We screened 368 via telephone and scheduled 137 for screening visits. A total of 85 women enrolled in the screening phase and 44 (29 PMDD + 15 NC) were randomized to intervention from 5/1/13 to 4/30/18. Of these, 15 PMDD and 8 NC completed the entire protocol and two participants completed at least one intervention arm.The University of California San Diego Institutional Review Board approved the protocol, and all participants gave written informed consent after procedures were explained fully. Participants were without alcohol abuse, significant medical illness, or medication that would interfere with study measures.To establish DSM-IV-TR (APA, 