RsfMRI preprocessing
RsfMRI preprocessing and subsequent analysis steps were performed in a blinded fashion and are illustrated in Supplementary Fig. Within the crossover design, each animal underwent two rsfMRI sessions in randomized order, one with psilocybin and one with saline. For all further analyses, each of the 36 min 30 s long rsfMRI dataset was split into a first dataset prior to drug application (time point 1 (TP1), first 340 frames, 0 min–8 min 30 s) and a second dataset starting 18 min after drug application (time point 2 (TP2), last 340 frames, 28 min–36 min 30 s), with the latter capturing the effects of psilocybin or saline.