Strengths and limitations
REGRESSION
This study comes with several strengths. First, we have provided an overview (Fig. The study comes with limitations, too. First, we only compared models in a single dataset; we have thus provided an example, but relative model performance and goodness-of-fit in other datasets may differ somewhat. Comparing model performance in multiple, real datasets would be valuable moving forward and is likely preferable to simulation-based model comparison, as the complexity of the distributions of DAWOLS and DAOH is a challenge with results likely to depend substantially on the data-generating model used in such simulations. Second, we considered a limited number of models and only focus on regression models, without considering non-parametric tests due to the limitations outlined in the background. Time-to-event/survival models have been used in some RCTs employing variants of DAWOLS (e.g., RCTs focusing on mechanical ventilation where all patients are ventilated at baseline [