Cost-effectiveness analysis
EQ-5D-5L measurements will be combined with survival times to derive an estimation of within-trial quality-adjusted life years (QALYs) for all patients. Within-trial health care costs will be estimated by applying unit costs to items of resource use (hospital admissions with length of stay, emergency department attendances, cardiac tests, and treatments). Cost-effectiveness analysis will take a health service perspective to estimate the incremental cost per QALY gained using the high-sensitivity troponin guided CTCA approach compared to usual care. Costs and QALYs beyond the trial will be estimated using decision-analysis modelling, based on adaptation of an existing model [