WGCNA analysis, drug sensitivity analysis, and immune microenvironment analysis of GBC
INFILTRATION
In this study, we conducted WGCNA analysis on sequencing data from two groups of GBC patients, employing a soft threshold of 14 (WGCNA analysis of two groups. We further performed a PPI analysis of the MEgreen and MEbrown gene modules and identified their top 10 hub genes (PPI analysis of WGCNA and drug sensitivity analysis. We also performed a drug sensitivity analysis for both groups, demonstrating that elderly GBC patients were less responsive to cisplatin and gemcitabine (The discrepancies in immune cell infiltration between elderly and young GBC patients.