Introduction
leucorrhea, vaginitis, ’ vaginal, bacterial vaginitis, dysbiosis, Vaginitis, vaginal itching, Infection
ADVERSE REACTIONS, INFECTIOUS DISEASES, VAGINITIS, DISEASE, BACTERIAL VAGINITIS, VAGINITIS, INFLAMMATION OR INFECTION, INFECTION
Edited by: Tingtao Chen, Nanchang University, ChinaReviewed by: Huaxi Yi, Ocean University of China, China; Qixiao Zhai, Jiangnan University, China; Faizan Ahmed Sadiq, Institute for Agricultural, Fisheries and Food Research (ILVO), BelgiumThis article was submitted to Clinical Microbiology, a section of the journal Frontiers in Cellular and Infection MicrobiologyVaginitis is the most common disease in gynecology. Vaginal dysbiosis is a main reason of bacteria vaginitis (BV), as the disrupted microecological environment facilitates the growth of various vaginal pathogens. The most dominant bacteria in the vaginal microbiota are lactic acid bacteria, which are important for maintaining vaginal health. At present, antibiotics and other drugs are often used in clinical treatment, but there are many adverse reactions and easy to relapse, and the intervention of probiotics can help restore vaginal microbiota and alleviate BV. This study is a human clinical trial of 50 patients with bacterial vaginitis (BV). The alleviation effect of applying a postbiotic gel for one week in BV was evaluated. Changes in patients’ clinical indicators of BV (properties of vaginal secretion) and the vaginal microbiota after using the postbiotic gel were monitored. Our results showed that apply the postbiotic gel improved the symptoms of BV, indicated by improvement in the abnormalities of patients’ vaginal secretions. After applying the gel, the relative abundance of vaginal lactobacilli increased compared to baseline. Significant negative correlations were found between lactobacilli and potential vaginal pathogens (including Vaginitis is one of the most common infectious diseases in female gynecology. It is mainly due to inflammation or infection of the vaginal area, and the clinical symptoms of which include vaginal itching, irritation, and discharge of secretion with unpleasant odor (The structure of the vaginal microbiota comprises mainly lactobacilli, and this group of microbes is thus indicative of vaginal health and homeostatic for the local acidic environment (pH < 4.5) (Probiotics are active microorganisms that confer beneficial effects on the host (Clinical identification of BV mainly relies on traditional methods of pap smear and biochemical analysis (This study recruited 50 patients with BV and investigated the therapeutic effect of one-week intervention with postbiotic gel. Changes in the severity of leucorrhea, biochemical properties and bacterial microbiota of subjects’ vaginal discharge after the gel intervention were analyzed. This study supports that the application of postbiotic gel could improve BV.