Definition of cell scores and signature
The fractions of major cell types were calculated using CIBERSORTx v.1.0.4 and Ecotyper v.1.0 with RNA-seq expression profiles. ESTIMATE v.1.0.13 was used to calculate immune score and stromal scores using bulk RNA-seq data. To determine the correlation between the signature associated with inflamed TME and clinical benefits, TIL score was calculated as the sum of CD45