Outcomes
death, tumour, N0, Cancer
DISEASE PROGRESSION, ADVERSE EVENT, TUMOUR, CANCER
Details of dynamic assessment were described previously.Secondary endpoints included: (1) lymph node downgrade rate defined as the proportion of patients with pathological confirmed lymph nodes downstaging from N2 to N1 or N0 in the intention to treat (ITT) population. (2) complete resection rate defined as the proportion of patients who received complete resection (R0 section) in the intention to treat (ITT) population. (3) pCR rate is determined as % residual viable tumour cells in the primary tumour and sampled lymph nodes. (4) OS was defined as the time from random assignment to the date of death from any cause, or data on patients were censored at the last confirmation of their survival. OS at 3 and 5 years is defined as the percentage of people still alive 3 or 5 years after the day of randomisation. (5) PFS defined as the time from surgery to the first confirmed disease progression or death from any cause, or data on patients were censored at the last tumour assessment. (6) safety (assessed by the US National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0).