Author contributions
MT collected the clinical data, supervised the protocol, provided feedback for intellectual content for this manuscript, and gave final approval for this manuscript to be published. JM, NA, and KL participated in patients’ enrolment, provided feedback for intellectual content for this manuscript, and gave final approval for this manuscript to be published. GD conducted the lab part of the study, provided feedback for the intellectual content for this manuscript, and gave final approval for this manuscript to be published. JKT participated in the drafting of the protocol and study design, provided feedback for intellectual content for this manuscript, and gave final approval for this manuscript to be published. EJGB designed the study, analyzed the data, wrote the manuscript, provided feedback for intellectual content for this manuscript, and gave final approval for this manuscript to be published.