Background
cognitive and mood disturbances, MM, FM, fatigue, pain
PATHOPHYSIOLOGY, FIBROMYALGIA (FM), MITOCHONDRIAL PATHOLOGY, FIBROMYALGIA, PATHOLOGY, MITOCHONDRIAL MYOPATHIES
The key symptoms of fibromyalgia (FM) include persistent, widespread pain, disturbed sleep, fatigue, and cognitive and mood disturbances [Aerobic and strengthening exercise are strongly recommended in the multimodal management of FM [Mitochondrial pathology, also suggested to be a part of the pathophysiology of FM [Altogether, FM symptoms share similarities with those of mitochondrial myopathies (MM) [We hypothesized that a possible pathology in muscle metabolism in patients with FM would result in altered exercise responses in a CPET and that pain intensity would affect exercise capacity. More precisely, if mitochondrial oxygen demand was decreased due to deficits in the cellular respiration pathways or simply due to lower muscle mitochondrial density, this would result in lower oxygen extraction and hence lower C(a-v)OThe work presented here is part of a larger study; Metabolism, Muscle Function, and Psychological Factors in Fibromyalgia, where the participants also underwent an electromyography study and an oral glucose tolerance test.