Effect of the clinic-based SAMBA assay on viral load suppression compared to SOC.
VL suppression, viremia
REGRESSION, VIREMIA
SOC = Standard of care, ITT = Intention to treat, OR = Odds ratio, VL = Viral load, CI = Confidence interval. In both models, we estimated the effect of the clinic-based SAMBA assay and 95% confidence interval using logistic regression.Of the 347/390 (90%) who remained in care, 279/347 (80%) were virally suppressed. There was no significant difference in VL suppression between the SOC 135/167 (81%) and the clinic-based SAMBA assay 144/180 (80%) arms. Nineteen percent of the CALWH tested with the Roche assay had low-level viremia (VL>20 and <1000 copies/ml). Among the 78 CALWH who were unsuppressed at baseline, 14 did not have 12 month VL. Of the 64 CALWH (30 SOC and 34 SAMBA) with 12 month VL, 36 (56%) were virally suppressed. In the SOC arm, 20/30 (67%) achieved VL suppression at 12 months compared to 16/34 (47%) in the clinic-based SAMBA arm (p = 0.115).Age group and baseline VL were independently associated with VL suppression at 12 months adjusting for gender, HIV care center, and time on regimen (