Clinical characteristics of patients with or without auto‐Abs for type I IFNs
death
CORONAVIRUS
In this study, the median age of the auto‐Abs positive patients was 56 years and 60 years for the auto‐Abs negative patients, and males represented 80% and 83%, respectively (Table (A) Baseline characteristics of patients in the trial and (B) study interventions and co‐interventions during the trial period.
Student's t‑test.Mann–Whitney test.Chi‑square test.Fisher's exact test.Patients without type I IFN auto‐Abs showed similar favorable responses to treatment interventions compared to patients with type I IFN auto‐Abs as shown in the forest plot (Supporting information Figure Outcomes in patients enrolled in the trial.
Abbreviation: MERS‐CoV, MERS coronavirus.Calculations of days free from supplemental oxygen, renal replacement therapy, mechanical ventilation, vasopressors, extracorporeal membrane oxygenation, organ support, and days outside the ICU were based on 28 days of observation.Days to MERS‐CoV RNA clearance censored by death or hospital discharge.Data on Karnofsky performance status score at Day 90 were not available for one patient in the placebo group. Otherwise, there were no missing values in the variables in this table.