Ethics approval and consent to participate
Participants were provided informed consent prior to enrollment into the main study, and all study procedures were done according to the ethical principles of human participants involved in medical research of the Declaration of Helsinki. Only those participants who understood and signed the written informed consent were then enrolled for study procedures. Approvals for the research were provided by the Medicines Control Authority of Zimbabwe (reference CT160/2017), the Medicines Research Council of Zimbabwe (reference MRCZ/A/2691), and the Harare Central Hospital Ethics Committee (reference HCHEC191020/49).