Background
mesenchymal tumors, Sarcomas, tumors
TUMORS, SARCOMAS, TRANSFORMING
Sarcomas are a rare, heterogeneous family of mesenchymal tumors, most of which are in an immunosuppressive state, with fewer responses to immune checkpoint inhibition than other adult tumors [Transforming growth factor-β (TGF-β), is a diverse regulatory and fibrogenic cytokine, which is expressed on multiple cells including mesenchymal stem cells (MSCs) and regulates cell cycle, migration, and immune response [TQB2858 is a new bifunctional fusion protein composed of a monoclonal antibody against PD-L1 fused with the extracellular domain of TGF-β receptor. 