2.1. Intervention
overweight or first-class obese
The study is a 12-week, double-blind, randomized, placebo-controlled clinical trial, 90 overweight or first-class obese subjects will be divided equally into 2 groups, a probiotics group, and a placebo group. A hypocaloric diet will be applied for both groups. Interventions will be performed in the first week and then continue to the twelfth week, in which all subjects will receive 3 boxes of either probiotics or placebo, all boxes are identical in color, weight, and shape. All subjects will be instructed to consume 2 sachets per day, first sachet is before the first meal by 10 minutes, and the other one before the last meal by ten minutes. For probiotics sachet, it contains granular powder with 6 microorganism strains (30 × 10