Data analysis
Numerical data were presented as mean and standard deviation values. They were tested for normality using Shapiro-Wilk’s test. PI and GI were non-parametric and were analyzed using Kruskal-Wallis test. Radiographic changes in bone defect (CEJ-BD, crestal bone level, and defect width) were statistically analyzed by paired t-test for intragroup comparisons and by covariance (ANCOVA) to compare the mean changes between the three groups using baseline data as a covariate. BMP-2 statistical analysis was performed by repeated measure ANOVA for data collected after 1 day, 7 days, and 14 days. P value of <0.05 was considered statistically significant.