Relevant concomitant care permitted or prohibited during the trial {11d}
Preoperative indication for the operation will be conducted in accordance with the Dutch guidelines, within a frame of mutual shared decision making, supported by a multi-disciplinary team meeting. There are no rules of behaviour for study participants other than described in the “Intervention description” paragraph added to the local protocol following surgery. All concomitant care is permitted during the study, no limitations are imposed.