Ethics approval and consent to participate
The study was conducted in accordance with the Declaration of Helsinki, and approved by the Institutional Review Board (or Ethics Committee) of Regional Ethical Review Board, Stockholm, Sweden (2018/652 − 31; 2018/1094-32; 2018/2393-32; 2020 − 00591; 2020–07005; 2022-02557-02). Registered at ClinicalTrials.gov (NCT03784612). Informed consent was obtained from all subjects involved in the study.