Bactericidal activity.
All the tested OPC-167832 doses appeared to have significant bactericidal activity (MAD/EBA study: bactericidal activity of OPC-167832. (A) Mean values (±SD) of sputum CFU/mL over the treatment period; (B) sputum lipoarabinomannan concentration over the treatment period; and (C) time to detection in mycobacteria growth indicator tubes over the treatment period.Bactericidal activity as differences between values at day 14 and baselineValues shown are mean ± SD; a negative value indicates reduction from the baseline value. LAM, lipoarabinomannan; MGIT, Mycobacteria Growth Indicator Tube; To further explore the applicability of LAM as a marker of treatment response, the relationship between LAM concentrations in the raw sputum (i.e., the sputum used for CFU counting) and the CFU/mL count on 7H11 medium was analyzed. Results indicated a strong correlation between log