Randomization and Blinding
Eligible patients were randomly assigned in a 1:1 ratio to receive either intravenous esketamine or intravenous midazolam for 40 minutes using a computer-generated block randomization scheme (block size, 4). An independent assistant who was not involved in the study was responsible for packing and labeling the prescribed medication. Study investigators, staff, participants, and all outcome assessors were blinded to the treatment assignment.