Limitations and significances
A few limitations in our study should be considered when interpreting our data. First, caffeine can induce neurovascular uncoupling by reducing baseline CBF and increasing baseline cerebral metabolic rate of oxygen consumption (CMRO2)In conclusion, daily moderate-dose caffeine intake might lead to a compromised working memory performance, which remains reduced after withdrawing caffeine for 36 h. The impaired behavioral performance, together with the absence of changes in the task-related neural activity, suggest that the increased neural metabolic demand for working memory execution by acute caffeine