Translational research
tumour
BLOOD, TUMOUR, METASTASES
Blood for biomarker research is collected from all participants at four timepoints: Cycle 1 Day 1, Cycle 2 Day 1, Cycle 4 Day 1, and end of treatment. Blood for pharmacokinetics (PK) is collected at three timepoints: Cycle 1 Day 15, Cycle 2 Day 1, and Cycle 2 Day 15 (optional) drawn before regorafenib is taken and 1 to 4 h afterwards. All blood samples collected are processed, frozen and biobanked. Archival tissue from the primary tumour or metastases are retrieved for translational research.