Evaluation of symptom improvement
TOLERANCE
Tolerance of positional changes was evaluated by having participants stand for 10 min, or as long as tolerated, following a 30-min supine period (10 min stand test) while heart rate was continuously monitored and blood pressure assessed at 1, 3, 5, and 10 min of standing. Subjects completed the Composite Autonomic Symptoms Questionnaire (COMPASS 31) used to assess the presence and severity of symptoms. The Short Form 36 Health Questionnaire (SF-36) was completed to assess quality of life and functional health/well-being reviewing physical component and mental component summary scores. Subjects rated their functional ability using a 0–100% scale categorized into 10% increments with 0% describing being completely bed ridden and 100% being able to work full-time with no modifications. This scale can be reviewed in the supplemental material and was used previously by Schofield and Chemali [