Baseline participant characteristics by bleeding events
Haemorrhage, bleeding, Stroke, bleed, Bleeding, subarachnoid haemorrhages
REGRESSION, BLEEDING, HAEMORRHAGE, SUBARACHNOID HAEMORRHAGE, STROKE, BLOOD, MINOR, EVENT, ACD, BLEED, BLEEDING, EVENTS
Of the 3096 TARDIS participants, 3072 (99.2%) had data pertaining to presence or absence of bleeding events. Of these, 444 (14.5%) had a bleeding event during the trial period. Bleeding severity was distributed as: fatal 0.4%, major 1.5%, moderate 1.2%, minor 11.4% and none 85.5% (Table Severity of bleeding by on-treatment parameters.Percentages (%) are of the row total rather than the column total. Comparisons performed using Jonckheere-Terpstra test for binary data, and Kendall Rank Correlation for bleeding scores. Intracranial-BBaseline characteristics of the patients by bleeding and its severity.Data are number (%), median [interquartile range] or mean (standard deviation). 2p = difference between any and none bleeding events. Trend ACD: aspirin, clopidogrel, dipyridamole; ASPECTS: Alberta Stroke Program Early CT Score; BP: Blood Pressure; intracranial-BBleeding by treatment groups.Data are number (%); comparison of three groups by Chi-square/Fisher’s exact test for direct comparisons or the Jonckheere-Terpstra test for trend. Haemorrhage is most severe, not first, bleed over 90 days. No subarachnoid haemorrhages occurred.ACD: aspirin, clopidogrel and dipyridamole; Asp: aspirin; Clop: clopidogrel; Dip: dipyridamole; MACE: major adverse cardiovascular event.Adjusted univariate associations between baseline variables and ordinal bleeding revealed that increasing age, female sex, increasing pre-morbid mRS, longer time from onset to randomisation, prior major bleed, and lower body weight were all associated with more severe bleeding events (Table Univariate and multiple variable associations between baseline variables and ordinal bleeding.Data are number (%) and odds ratio or ß with 95% confidence intervals. Comparisons by binary logistic regression, ordinal logistic regression or multiple linear regression models with adjustment for baseline factors. Stroke/TIA is given by severity; where a patient had more than one event over 90 days, the most severe event is used.ASPECTS: Alberta Stroke Program Early CT Score; BP: blood pressure; Intracranial-B