MRI severity of brain injury and Bayley Scales of Infant Development-III (BSID-III) outcomes.
white matter lesions
MRS
BSID-III Central gray, peripheral watershed, and global injury patterns were each associated with worse BSID-III cognitive, language, and motor scores when compared to infants with no injury, while infants with only punctate white matter lesions or atypical lesions did not differ significantly in BSID-III scores when compared to infants with no injury (e-Fig. Thalamic MRS data were available in 297 of 390 (76%) survivors who underwent a BSID-III evaluation. The thalamic lactate/NAA ratio was associated with all three BSID-III scores; i.e., for every 0.10 increase in this ratio, there was an adjusted mean difference of BSID-III scores as follows: cognitive −0.7, 95% CI −1.1, −0.4; language −0.8, 95% CI −1.3, −0.3; and motor −1.0, 95% CI −1.4, −0.5. The lower thalamic NAA/creatine ratio was similarly associated with lower BSID-III scores (Fig. 