Background
sleep disorders, fatigue, breast cancer, anxiety/depression, cancer, Breast cancer, pain, sleepiness, insomnia, depression
CANCER, BREAST CANCER, BREAST CANCER
Breast cancer is the most commonly diagnosed cancer in women, with an incidence of 11.6% worldwide in 2018 [A physical exercise program might be a promising treatment option for preventing cancer-related insomnia, and appears to be safe. Previous studies showed that improved sleep quality positively impacts on quality of life in cancer patients [Moreover, exercise is recommended during treatment with curative intent. Aerobic and resistance exercise has been shown to reduce fatigue, preserve cardiorespiratory fitness and physical functioning, as well as improve quality of life and depression symptoms [However, few studies have explored the efficacy of an exercise program for cancer-related insomnia among patients undergoing breast cancer treatments. In this regard, we hypothesize that exercise programs can have a beneficial effect on insomnia for breast cancer patients.We designed the present randomized FATSOMCAN trial, to examine, in non-metastatic early breast cancer patients with an insomnia diagnosis, the effect on sleep quantity of an individualized, intermittent aerobic exercise training regimen (45 min, 3 times a week), comprising both moderate and high intensity exercise, for a period of 3 months. Secondary objectives are to evaluate the effects of this supervised exercise program on other parameters such as sleep disorders, sleepiness, anxiety/depression, core body temperature and salivary melatonin rhythm. Furthermore, fatigue, pain, inflammatory and cardiorespiratory fitness variables, and level of physical activity (PA) are assessed.We hypothesize that a supervised exercise program will reduce insomnia and improve the quality and quantity of sleep. Exercise will increase cardio-respiratory fitness, with an improvement in inflammatory variables. We suppose that these modifications will be accompanied by a reduction in sleepiness, anxiety/depression, fatigue and pain. Moreover, we hypothesize that patients who participate in the supervised exercise program will maintain these benefits at the three-month follow-up.