Patients
drug abuse, alcohol abuse, coagulation dysfunction, HCV infection
BRAIN METASTASIS, METASTASIS, HIV INFECTION, SECONDARY, DISEASES, TUMOR RECURRENCE, CORONARY ARTERY DISEASE
The patients were included based on the following inclusion criteria: (1) diagnosed with CRC, with TNM stages of IIIb–IV; (2) 18 to 75 years old male or female, with at least one radiographically measurable lesion; (3) patients had tumor recurrence or metastasis after surgery and chemotherapy, and their life expectancy should be at least 3 months; and (4) serum bilirubin not higher than 1.5 times the upper limit of normal (ULN), ALT or AST not higher than 2.5 times ULN, and creatinine clearance higher than 50 mL/min. For chemotherapy and targeted drug therapy, patients were required to have a washout period of at least 2 weeks.Patients were excluded from this study based on the following criteria: (1) patients with HIV infection, HCV infection, serious coronary artery disease, or other diseases deemed unsuitable for inclusion in this study by the researchers; (2) patients with a history of bone marrow or organ transplantation; (3) patients with coagulation dysfunction; (4) drug abuse, alcohol abuse, clinical or psychological or social factors affecting informed consent or study implementation; (5) patients with secondary brain metastasis; and (6) any uncertain factors affecting the safety or compliance of patients.