4.3. Randomization
death, septic shock
ADVERSE EFFECTS, SEPTIC SHOCK
Computerized electronic selection was used to divide the patients into blocks; Randomization was 1:1 in balanced blocks. There were 6 blocks, with an approximate number of 25 patients per block. Personnel who were not involved in the study participated in the blinding and placed the indicated therapy in identical opaque envelopes numbered from 1 to 125, and these were applied consecutively. Group 1 received Vit C, Group 2 received Vit E, Group 3 received NAC, Group 4 received MT, and Group 5 was the control group with antioxidant treatment. Of 3745 patients admitted to the ICU during this study, only 131 had septic shock. Once the diagnosis of septic shock was established (inclusion criterion), we applied treatment with antioxidants to patients according to randomization. We show the number of patients who entered each group and the type of treatment they received. Additionally, we provide the conditions that occurred during follow-up (intervention discontinuation, adverse effects, death) in each group and show the number of patients finally included in the analysis (