5. Conclusions
ADHD
DISORDER
Our study revealed significantly higher peripheral S100B levels in patients with ADHD compared to controls, strengthening the hypothesis of glial damage within the mechanisms preceding the catecholaminergic disruption responsible for this disorder. Therapeutic administration of MPH, aMT, and ω-3 PUFAs was followed by a paradoxical transient increase in S100B levels, that would require further investigation in future trials with different treatment arms and longer follow-up periods.