Outcomes
tumor, pneumonia, death, toxicities, hematological toxicity, weight loss
DISEASE PROGRESSION, TUMOR, METASTASIS, PNEUMONIA, ACUTE ESOPHAGITIS, SECONDARY
The primary endpoint was the change of weight during CCRT, which was defined as the percentage of weight loss from baseline till the end of CCRT. The secondary endpoints were nutrition status, measured by the change of albumin, hemoglobin, and CRP level during CCRT; loco‐regional objective response rate (ORR) was evaluated by tumor in the esophagus and mediastinal nodes, excluding distant metastasis; loco‐regional progression‐free survival (LRFS), defined as the time from enrollment to the date of loco‐regional disease progression or death from any cause or censored at the last date of follow‐up; overall survival (OS), defined as the time from enrollment to death or censored at the last date of the follow‐up; ≥3‐grade acute esophagitis, pneumonia, and hematological toxicity. Nutrition status was evaluated at the end of CCRT. ORR was assessed 2 months after CCRT. Acute toxicities were evaluated from the start till 3 months after CCRT.