Author contributions
AO, AZ and CS designed and managed the study with input from all other authors. AZ and AT did the statistical analyses. AZ was responsible for patient-reported outcomes. All authors participated in data interpretation. AO, AZ, CS, HD, and KK verified the underlying data. AO drafted the first and subsequent versions of this paper with input and key revisions by all authors, who reviewed and approved the final submitted paper. All authors read and approved the final manuscript.