Results of adjuvant chemotherapy and toxicity
toxicity, anastomotic stricture
SURGICAL COMPLICATIONS, RECURRENCE, LEAKAGE
The median times from operation to initiating AC were 13 (range 4–43) days in the EAC arm and 29 (range 17–53) days in the CAC arm (safety population) (Results of adjuvant chemotherapyValues are The median number of administered cycles and completeness of chemotherapy, including the rate of completion without dose reduction or delay, the rate of completion with dose reduction or delay, the rate of completion of FL with discontinuation of oxaliplatin, and the rate of discontinuation of chemotherapy, were similar between the two arms. The most common reason for discontinuation of chemotherapy was toxicity in both arms, and five patients in the CAC arm had to discontinue the study protocol treatment and change to another chemotherapeutic regimen due to recurrence, compared with no recurrence during AC in the EAC arm.Although there were two cases of postoperative surgical complications in the EAC arm (one case of anastomotic leakage and one case of anastomotic stricture) compared with none in the CAC arm, there was no statistically significant difference (1.0 per cent in the EAC arm The relative dose intensities of oxaliplatin in the two arms were similar and decreased to 80 per cent at the seventh cycle of AC in both arms (Relative oxaliplatin dose intensity during each cycle (safety population)*The ratio of the median of the actual dose to the initial dose that is recommended by guidelines. EAC, early adjuvant chemotherapy; CAC, conventional adjuvant chemotherapy,Details of toxicity are presented in 