Author contributions
AIH
AIH was responsible for the study conceptualisation and design, analysis of demographic data, interpretation of results, and preparation of the manuscript. EK and JW were responsible for analytic design, data analysis, and interpretation of results. MG, MAB, AJS, JD, AF, NT and BFD were responsible for conceptualisation of the study. AJS, AIH and MAB coded clinical study variables. BFD collected and curated the data for the primary study and was responsible for clinical contact with participants. All listed authors reviewed the manuscript and agree to be accountable for all aspects of this work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.