Discussion
COPD
DISEASE PROGRESSION, OXIDATIVE STRESS, INFLAMMATION, COPD EXACERBATION, CHRONIC RESPIRATORY DISEASE, COPD, OXIDATIVE STRESS
COPD is the most common chronic respiratory disease, with a high prevalence rate, high disability rate, high mortality characteristics, a serious threat to human health. According to a statistical report, the number of COPD patients worldwide reached 544.9 million in 2017, an increase of 39.8% since 1990 [Currently, glucocorticoids, as the most common used anti-inflammatory drugs, are widely used in the treatment of acute COPD exacerbation and stable stage [Oxidative stress directly damages airway and lung tissues, leads to protease/antiprotease imbalance, promotes inflammation, and plays an extremely important role in the occurrence and development of COPD [Additionally, we also observed increased SOCS5 expression and inactivation of the JAK2/STAT3 pathway after IMT, NIPPV and sequential NIPPV + IMT therapy, suggesting that the SOCS5/JAK2/STAT3 signaling pathway might be involved in its mediated changes in oxidative stress levels and disease progression in COPD patients. SOCS family proteins are a class of negative regulators of JAK2-STAT3 signaling pathway, consisting of SOCS1-7, both containing Src-homology domian and a conserved C-termial domain [