5. Conclusions
β-cryptoxanthin ingested as a purified supplement was found to be safe and well-tolerated at doses up to 6 mg/day for 8 weeks in healthy women. The pharmacokinetic profile demonstrated that β-cryptoxanthin plasma concentrations increased in a dose-dependent manner over time following daily supplementation. No significant changes in plasma concentrations of other carotenoids, blood retinol-dependent gene expression, mood, physical activity and sleep, metabolic parameters, and fecal microbial composition were observed after 8 weeks of supplementation with β-cryptoxanthin at up to 6 mg/day in healthy women.