Anthropometric indicators
TG, hypoglycemic, diabetes
ADVERSE EVENTS, HYPOGLYCEMIA, INSULIN RESISTANCE, BLOOD, DIABETES
The general patients information collected included sex, age,diabetes history, height, weight, BMI, waist circumference, hip circumference, and insulin dose. Fasting blood glucose (FBG), HbA1C, C-peptide, cholesterol (CHOL), triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) levels were measured during the screening period and after 12 weeks of treatment. An automatic biochemical analyzer assessed hypoglycemia, adverse events, alanine aminotransferase (ALT), aspartate transaminase (AST), creatinine (Cr), and uric acid (UA).The insulin resistance index was assessed for each patients using modified homeostasis model, and expressed as [HOMA-IR(CP)] = 1.5 + FPG (mmol/L) × fasting C-peptide (pmol/L)/2,800 (The oral glucose tolerance tests (OGTT) experiment was conducted during the lead-in period, where participants received 75 g of orally-administered glucose in the morning after fasting for 10 to 12h. Blood samples were collected at 0, 60, and 120 min afterward, to measure plasma glucose concentrations.After 12 weeks of treatment, the participants fasted overnight, were treated with their corresponding hypoglycemic drugs (Ins, Ins+Met, or Ins+SZ-A), and consumed 70 g of instant noodles (500 kcal, 70 g of carbohydrates) within 15 min (