Study endpoints and analysis
Study related data was captured electronically (eCRF) using the secuTrial data capture system maintained by the clinical trials unit of the University Hospital Basel. The primary endpoint of the study was CIT after one week of prednisone as compared to placebo. Secondary endpoints were fat content of supraclavicular BAT (scBAT, determined by MRI), volume of scBAT (determined by MRI), supraclavicular skin temperature, scBAT activity determined by FDG-PET/CT (SUVWilcoxon signed-rank tests, t-tests and two-way ANOVAs were calculated and figures were created in GraphPad Prism Version 9 (GraphPad Inc., La Jolla, CA).In order to test for the effect of co-variables and random effects on CIT and glucose uptake into BAT we used mixed-effects models in the statistical computing package R (Version 4.1