Assessment of treatment attributes at baseline
difference/less
EVENTS, SECONDARY
Important considerations for future glucose-lowering therapies prior to randomisation were assessed at baseline with a 1-4 Likert scale from ‘very important’, ‘important’, ‘unimportant’ to ‘very unimportant’.Prior to each treatment period, participants were provided with a paper ‘reporting card’ to collect any noteworthy experiences or events. Completion was optional, they served as memory aide for the 16-week period. At the end of the treatment period study visit, participant experience questionnaires were completed by the participant themselves. Ahead of the final study visit, copies of documents from all three treatment periods were provided along with a summary showing whether at the time they had felt the drug had made their lives more difficult/no difference/less difficult, and whether they would be willing to take it again. Participants were asked to consider their experiences with a view to expressing a preference at the visit.At the final study visit, participants were asked to rank each of the drugs in order of preference on a scale of 1 to 3 (1 being most preferred to 3 being least preferred). Participants were asked to rank the drugs twice: once before they received information on their HbA1c result and weight on each of the therapies and once again after being fed back these results. Main preference results are shown as both mean rank (in line with the secondary endpoint in the SAP) and preferred drug. As our main analysis aimed to explore reasons for patient preference, analysis was mainly focussed on examining associations with preference as a binary variable (preferred v not preferred drugs), as in real life patients would only continue with taking one drug. Therefore, participants that could not decide on a preferred drug were excluded from analysis. Participants were asked, for each of the study drugs, whether they would continue taking them long term.