4. Discussion
bleeding, hypothermia, ischemia, pain, infection, shivering
BLEEDING, DELAYED WOUND HEALING, POSTOPERATIVE COMPLICATIONS, ISCHEMIA, INFECTION
This study demonstrated that group R showed lower rates of incidence and severity of PS, the incidence of hypothermia, and the frequency of meperidine administered for PS treatment compared to group S. The incidence of PS or PS severity requiring meperidine treatment was moderately associated with the incidence of hypothermia in group R but not in group S. Maintaining anesthesia with remimazolam compared to sevoflurane showed better results for hypothermia and PS after general anesthesia, showing a correlation between hypothermia and PS. These results may be due to the higher vasoconstriction threshold and faster vasoconstriction time of remimazolam, a benzodiazepine, compared to other inhalational or intravenous anesthetics [When it comes to intravenous drugs, the reduction in thermoregulatory thresholds for shivering and vasoconstriction usually occurs in a linear dose-dependent manner. However, with volatile anesthetics, the thresholds for vasoconstriction and shivering tend to decrease in a non-linear fashion as the concentration of the volatile gas increases [The clinical impact of PS includes obvious discomfort and postoperative complications, such as pain, bleeding, critical ischemia, infection, delayed wound healing, and increased hospital stays [Our previous study [Kiekkas et al. [The present study has some limitations. First, core BT was measured using an infrared pre-induction thermometer in the PACU and a nasopharyngeal probe during surgery. However, measurement errors may occur between these two methods and sites [