2.1. Transcriptomics
Lesional skin punch biopsies from 12 sample pairs taken from the edge of an active HS lesion [In the pathway enrichment analysis, a number of inflammatory pathways were found to be enriched in the Week 8 DEGs from the 30 mg povorcitinib QD group (We previously reported on a 128-gene signature of HS [Treatment-related changes with 30 mg povorcitinib QD were also assessed on two previously published gene sets from HS lesional (vs non-lesional) and wounded (vs non-wounded) skin. The overlap of DEGs in HS lesions with genes expressed during wound healing was previously reported [