Introduction
deaths, colorectal cancer
METASTATIC COLORECTAL CANCER, COLORECTAL CANCER, RECTAL CANCER
Over 1.9 million new colorectal cancer cases and 915,880 deaths were estimated to occur worldwide in 2020 [Fluorouracil-based preoperative chemoradiotherapy (CRT) followed by total mesorectal excision (TME) and adjuvant chemotherapy remains the standard treatment for locally advanced rectal cancer (LARC) [After consideration of the long-term side effects elicited by radiotherapy, several studies have endeavored to explore the role of neoadjuvant chemotherapy (nCT) as monotherapy. In the FOWARC study, though the neoadjuvant with mFOLFOX6 alone achieved a postoperative pCR rate of 6.6%, the rates of R0 resection (89.4% Given the low pCR rate with mFOLFOX6 in the FOWARC study, we conducted a phase 2 clinical trial to evaluate the efficacy and safety of mFOLFOXIRI, a more intensive and more active triplet regimen proven to be effective for the treatment of metastatic colorectal cancer [