Participants
psychiatric, anxiety, dyslexia
ADVERSE EFFECT, DISORDERS
Thirty-six healthy participants (18 males, aged 18–31) were recruited through advertising. Following the local ethics committee guidelines (NRES committee South central–Oxford REC B 10/H0605/71), written and oral consent was obtained. Participants had a body mass index of 19–30, were physically fit as assessed by a medical doctor, and had normal laboratory values of thyroid and renal function. Additionally, females tested negative on a pregnancy test and were using two forms of contraception. Participants were excluded if they took any psychotropic medication, had any past or current psychiatric including mood and anxiety disorders, had any medical contra-indication (see the Supplementary Material), had current or past history of drug or alcohol dependency, smoked more than 5 cigarettes a day, had dyslexia, had any contra-indication to magnetic resonance imaging (MRI) scanning, or were left-handed. A total of 3 participants were further excluded from the experiment and/or analysis due to treatment non-compliance (1x), unexpected adverse effect (1x; reported anxiety increase), and incomplete MRI session (1x), leaving a total of 33 participants for analysis.