Titrations
tremor, fatigue
A sub-cohort of 10 individuals (3 female) completed a stimulation amplitude titration experiment, off medication. These participants had been implanted with investigative deep brain neurostimulators that recorded STN local field potentials synchronously with kinematic signals during a variety of tasks. Testing was done once optimized on DBS settings and 1.5–3 years after their initial programming visit, and at a time when they tolerated changing of stimulation. Participants in this study did not have tremor that superseded the entire trial of the WFE task. In some subjects, only one wrist was assessed if the subject had excess neural artifact that resulted in that limb/STN being excluded from the experiment. Furthermore, due to protocol time restrictions and fatigue for the subjects, one or both wrists were assessed (randomized in order). Participants performed five trials of the rWFE task, where a single trial was performed unilaterally on one randomized side. Each trial was performed during randomized presentations of STN DBS at 0% (no DBS), 25%, 50%, 75%, and 100% of V