INTRODUCTION
obesity, thirst, impairment, dysfunction, and failure, Diabetes, vision impairment, weight loss, T2DM, diabetes
DISORDER, OBESITY, TYPE 2 DIABETES MELLITUS, INSULIN RESISTANCE, DIABETES, TYPE 2 DIABETES MELLITUS, DIABETES
Pyridoxal-5-phosphate (PLP) is the bioactive derivative of vitamin B6, functioning as a coenzyme in over 150 metabolic pathways. Insufficient PLP levels could be associated with the onset and progression of diabetes. This study aimed to assess the effects of pyridoxine adjuvant treatment on blood glucose levels in patients with type 2 diabetes mellitus (T2DM). This interventional, randomized, open-label study was conducted in the Mesan Governorate, with participants from the Mesan Center for Diabetes and Endocrinology as the study population. This study included patients newly diagnosed with T2DM. Patients were randomized into three groups: Group 1, the control group, treated with non-pharmacological therapy (lifestyle modification) (n=20); Group 2, treated with Metformin 500 mg/day in addition to non-pharmacological therapy (lifestyle modification) (n=20). Group 3 was treated with Metformin 500 mg/day plus vitamin B6 300 mg/day in addition to non-pharmacological therapy (lifestyle modification) (n=68). The findings revealed a considerably favorable impact of pyridoxine adjuvant treatment with Metformin on blood glucose levels and other study variables. Compared to the patients in the control group G1, the reductions in fasting plasma glucose (FPG) and glycated hemoglobin (HbA1c) were statistically significant in groups G2 and G3 after a 4-week treatment period. Similar results were observed for fasting serum insulin and homeostasis model assessment of insulin resistance (HOMA-IR) levels, with a significant decrease in groups G2 and G3 (p<0.05). Furthermore, the reductions in indoleamine 2,3-dioxygenase levels were also significantly higher in groups G2 and G3 at the end of the 4-week treatment period (-14.48% Type 2 diabetes mellitus (T2DM) can cause persistent impairment, dysfunction, and failure in multiple organs. While the initial symptoms of T2DM may include weight loss, frequent urination, thirst, hunger, and vision impairment, it is essential to note that this disorder also has long-term effects [The factors contributing to the prevalence of T2DM include growing urbanization, limited engagement in physical exercise, a lack of activity, and obesity. While it may not be possible to modify all causes, a significant portion may be addressed by appropriate lifestyle habits, avoiding drug misuse, and implementing screening measures to detect potential issues [According to Salvo The present study aimed to assess the effect of pyridoxine adjunctive treatment on the glycemic status of individuals diagnosed with T2DM.