Additional rules
All changes in TAC dose (including all non-study visits) must be performed according to the study protocol and the current TAC trough level target. TAC adaptions have to be made within 48 h after the receipt of the TTV load. The lowest TAC trough level target is 3.5 ng/mL, and the highest is 10 ng/mL. The treating physician can request additional TAC trough levels at any time (also on non-study visits) but TTV load will only be assessed and TAC trough level target changes only performed at the study visits. If non-adherence is suspected, no increase in TAC trough level target will be performed: e.g. a failure of TAC intake more than once per week on average for b.d. and once every 2 weeks on average for o.d. formulation detected by the patient diary. In this case, the patient should be educated about medical adherence (e.g. psychological counseling) and the target TAC trough level will not be changed according to TTV load until the next study visit.