Materials and methods
MAY, RECRUITMENT
This study protocol was approved by the Ethics Committee of Shenzhen Children’s Hospital of China Medical University (IRB no. 201,904,802). The rights of the participants were protected, and at least one of each patient’s parents or a legal guardian signed a statement of informed consent before the patient was enrolled. All participating children were verbally informed of the relevant trial protocol in advance. The study was performed in accordance with the World Medical Association Declaration of Helsinki ethical principles for medical research involving children. The participant recruitment began on January 20, 2021, and the study was completed on May 31, 2021.