Background
bradycardia, nausea, postoperative pain, Postoperative nausea and vomiting, pain, dehydration, hypotension, PONV
COMPLICATION, DEHYDRATION, WOUND DEHISCENCE, CAVITY, ASPIRATION PNEUMONIA, ELECTROLYTE IMBALANCE, COMPLICATIONS
Postoperative nausea and vomiting (PONV) is a distressing and unpleasant post-surgical complication. PONV affects patient satisfaction and may lead to other complications, such as dehydration, electrolyte imbalance, aspiration pneumonia, increased wound dehiscence, delayed recovery, and prolonged hospital stay. Particularly, in oral and maxillofacial surgeries, PONV may affect the surgical site or the oral cavity [In clinical trials, total intravenous anesthesia (TIVA) with propofol has been shown to reduce PONV significantly more than inhalational anesthesia. Therefore, propofol is the recommended anesthetic for patients at high risk of PONV [Remimazolam is a novel benzodiazepine that is rapidly metabolized into inactive metabolites via hydrolysis by tissue esterases. The short, context-sensitive half-life of remimazolam makes it possible to use it as a general anesthetic. The efficacy and safety of remimazolam have been compared with those of propofol, and reports indicate some advantages of remimazolam, such as absence of injection pain and a lower incidence of hypotension and bradycardia [However, few studies have investigated the incidence of PONV with remimazolam. Therefore, this study was conducted to compare the effects of remimazolam and propofol on PONV in patients undergoing oral and maxillofacial surgery, in which control of PONV is important. The primary outcome was the overall incidence of PONV during the first 24 h after surgery. Secondary outcomes included the severity of nausea, use of rescue antiemetics, severity of postoperative pain, use of rescue analgesia, and quality of recovery.