Relationship between methylphenidate-induced changes in brain state dynamics and response variability
Methylphenidate-induced, medication-induced, ADHD
REGRESSION
We then determined whether methylphenidate-induced changes in brain state dynamics are associated with changes in IIRV in the CPT. We focused on state S2 which we found to be aberrant in children with ADHD, as detailed above. Specifically, we conducted a multiple linear regression analysis to evaluate the relationship between methylphenidate-induced changes in occupancy rate and mean lifetimes of S2 and medication induced changes in IIRV controlling for potential confounding influences of age, IQ and SES. Methylphenidate-induced changes in occupancy rate of S2 is the only significant predictor for medication-induced changes in IIRV (