Statistical analysis
psychotic symptoms
SECONDARY
For randomised participants, an intention-to-treat approach will be taken for data analysis by including all randomised participants in statistical analyses, regardless of the treatment they received (if any). We will compare outcome measures between treatment and placebo groups controlling for baseline scores. This mechanistic experiment will focus on overall pattern of results and their effect sizes rather than p values for individual tests of statistical significance. The secondary mechanistic and observational analysis will compare psychotic symptoms, cognitive function, blood, neuroimaging and other biomarkers between and across study groups using appropriate statistical tests.