4.1. Strengths and Limitations
The present trial overcomes several limitations of previous trials of the use of NSBs as a replacement strategy for SSBs. First, it uses a “real-world” fully pragmatic design with NSBs products available on the Canadian and global markets [Some limitations remain. First, the multiple crossover design with three treatment phases, two washout periods, and multiple measurements may have contributed to a reduction in retention. Our retention of 82.5% for the main trial and 81.3% for the Ectopic Fat sub-study, however, would meet criteria for good retention [