Introduction
traumatic brain injury, inflammation, traumatic, hemorrhagic shock, ischemia/reperfusion injury, Traumatic injuries, trauma
INFLAMMATION, HEMORRHAGIC SHOCK, INFLAMMATORY RESPONSE
Traumatic injuries continue to be a leading cause of mortality worldwideAn intervention that has been shown to lessen the magnitude of ischemia/reperfusion injury is called Remote Ischemic Conditioning (RIC)In the trauma setting, Joseph et al. demonstrated that RIC applied in patients following traumatic brain injury exerted neuroprotective effects, as determined by a reduction of neuronal biomarkers of acute brain injury in the bloodWe hypothesized that RIC may suppress the inflammatory response associated with traumatic resuscitated hemorrhagic shock. The major objective of this clinical trial is to investigate the potential immunomodulatory effects of posttraumatic application of RIC in trauma patients sustaining hemorrhagic shock by evaluating markers of neutrophil activation and systemic inflammation during the acute phase of injury.