Postprandial Age Effect in the Serum Volatilome
OA
INTESTINAL INFLAMMATION
All
of the 19 serum metabolites detected with a significant difference
between the OA and YA groups were characterized by a higher postprandial
response for older men than young men (see An age effect was observed for the postprandial
response of nine fatty acids. The response for acetic acid was different
between the age groups only after milk intake. Conversely, age-specific
responses were only observed for 3-methylbutanoic acid, 2-methyl-2-butenoic
acids (Numerous studies have shown that short-chain
fatty acids, mainly
produced from dietary fibers by the gut microbiota, have beneficiary
effects, in particular through the improvement of gut barrier function
and the reduction of intestinal inflammation.Cluster 3 is characterized by two phenolytic
compounds, namely,
phenol and The significantly higher postprandial
increase in Given the large interindividual variability observed
in the postprandial
appearance of The flavonoid 2-coumaranone was associated with a postprandial
age effect. Although the metabolite could be detected only in yogurt,
it was present in the serum both after milk and yogurt intake. 2-Coumaranone
has been previously identified in Older adults release higher incremental levels of 18 metabolites,
among these branched-chain fatty acids, than young adults in the bloodstream
after yogurt intake whereas this was the case for only 5 metabolites
after milk intake. This effect could potentially be explained by differences
in the food matrix: intestinal metabolite uptake can indeed be influenced
by changes in the microstructure or physicochemical properties (