Introduction
Pain, AVF, HD, pain, arteriovenous fistula
ANESTHESIA OF MUCOUS MEMBRANE
Pain is defined as an unpleasant sensation and emotional experience [The HD is the most frequently used renal replacement therapy, and an arteriovenous fistula (AVF) is the gold standard for vascular access in these patients [On the other hand, a painful procedure can instill a sense of distrust in medical staff; the patient’s pain intolerance also increases the risk of occupational accidents, such as inserting an infected needle in the nurse’s hand [For pain reduction, some methods have been suggested and studied, including the use of topical anesthetics, such as lidocaine [The injectable anesthetics are not used for venipuncture or intramuscular injection alone because their injection is as painful as venipuncture or injection [Another form of topical analgesic includes sprays. One of the most well-known types of these sprays is lidocaine spray. Lidocaine spray is used for the topical anesthesia of mucous membranes and skin. The beginning of its practical effect and its easy-to-use method has led to its widespread use, compared to other methods [Furthermore, the existing evidence on the usefulness of cooling sprays is of medium quality and cannot be relied on [