2.14. Statistical Analysis
REGRESSION
Descriptive data were expressed as mean ± standard deviation. Normality was confirmed using a Shapiro–Wilk test and a visual check of histograms. Unpaired t-tests were implemented (i) to identify potential differences between groups at the baseline and (ii) to determine changes in exosomes between CT vs. CG. Additionally, multilevel mixed analysis was used to analyze the differences in exosome cargo between CT and CG. Net effect (mean difference and standardized mean difference; SMD) was calculated to estimate the clinical relevance of intervention considering the small sample size included in the current study. To examine the relationship between potential changes in exosomes after the intervention and changes in cardiometabolic health parameters (cardiorespiratory fitness, fat mas, blood pressure, Protein C reactive, echocardiography…) in our cohorts, we performed single linear regression analyses, with 