MIST2
Sepsis
EVENT, SEPSIS, PLEURAL INFECTION
The Second Multicenter Intrapleural Sepsis Trial (MIST2) was a 2 × 2 factorial trial evaluating the use of tPA and deoxyribonuclease (DNase) in participants with pleural infection.In this trial, the mITT estimator is appropriate. First, the intercurrent event (‘failure to begin study treatment’) can be identified and measured in each treatment arm. Second, treatment allocation should not influence the occurrence of the intercurrent event, as the trial is double-blinded, so those deciding on whether to initiate treatment will not be aware of whether it is tPA or placebo being initiated.