Author contributions
J.Y.L., H.Y.O., and L.M.C. developed the concept for this article. C.Z.W., C.Y.Y., J.Y.J., C.H.L., Y.D.J., T.J.C., Y.C.C., W.C.W., H.Y.L., Y.F.D., C.H.L., H.C.H., K.J.T., N.C.Y., S.Y.L., N.C.Y., S.Y.L., H.I.Y. enrolled their patients into this study. M.L.H. performed the FGF-21 assay. J.Y.L., H.Y.O., and L.M.C. analyzed the data and wrote the manuscript. All authors were responsible for reviewing and revising this article and assume responsibility and accountability for the results.