Estimated total duration of pain per day
pain
The estimated total duration of pain per day was assessed using a five-item scale on study days 2–14 of the treatment period. On study day 2, 50.0% (62/124) of patients in the bilayer tablet group and 54.6% (65/119) of patients in the IR capsule group reported that their duration of pain was < 4 h. This percentage increased slightly in both groups to 59.6% (62/104) in the bilayer tablet group and 60.4% (55/91) in the IR capsule group on study day 14 (Supplementary Table 