Clinical neuropathy scores
hypoesthesia, hyperalgesia, neuropathy, hypoalgesia, pain, neuropathy disability, NSS, DSPN, Neuropathy
HEAT, COLD, NEUROPATHY, NEUROPATHY
At baseline, according to NDS and NSS scores, 9 (64%) participants of the M-Diet group and 8 (47%) participants of the FMD group had DSPN (Neuropathy assessment and metabolic outcomes.Data are shown as mean ± SEM. P-value represents comparison of change between the groups. Bold values represent statistical significance changes (P<0.05).Parameters of quantitative sensory testing were compared to reference values, which were used to calculate z-scores for all single tests, except PHS and DMA: z-score positive values = hyperalgesia, z-score negative values = hypoesthesia or hypoalgesia.*P<0.05, **P<0.01, ***P<0.001 and represents the difference between baseline and after intervention values within the study group.M-Diet, Mediterranean diet; FMD, fasting-mimicking diet; NSS, neuropathy symptom score; NDS, neuropathy disability score; NCV, nerve conduction velocity; SNAP, sensory nerve action potential; CMAP, compound motor action potential; CDT, cold detection threshold; WDT, warm detection threshold; TSL, thermal sensory limen; CPT, cold pain threshold; HPT, heat pain threshold; PPT, pain pressure threshold; MPT, mechanical pain threshold; MPS, mechanical pain sensitivity; WUR, wind-up ratio; MDT, mechanical detection threshold; VDT, vibration detection threshold; FA, sciatic nerve’s fractional anisotropy; FPG, fasting plasma glucose;, BMI, body mass index; FPG, fasting plasma glucose; LDL, low-density-lipoprotein; HDL, high-density-lipoprotein.