Relationship between TME and immune status in different risk subgroups
PCa, RS
INFILTRATING
In this study, we used the CIBERSORT package to further analyze the differences between the different risk subgroups of PCa patients in terms of immune infiltrating cells. As shown in Fig. 8a,b, B cells naïve, B cells memory, T cells CD8, T cells follicular helper, T cells gamma delta, and monocytes were more abundant in the LDR group, while T cells regulatory, NK cells activated, Macrophages M0, Dendritic cells activated and Neutrophils were more abundant in the HDR group. These results suggest a strong link between TME and the prognosis of PCa patients. Immunotherapy for PCa has been the focus of attention, and immune checkpoints are important targets for immunotherapy. We further analyzed the expression of immune checkpoint genes CTLA4 and PDCD1 among different risk subgroups, as shown in Fig. Correlation analysis between RS and TME (