Symptom and medication scores
There was a difference in dSS, dMS and dCSMS between the groups throughout the birch pollen season 2019. The treated group experienced less symptoms with mean AUC 19.6 [SD 8.8 (95% CI 15.6–23.6)] compared to the placebo group with mean AUC 24.8 [SD 6.9 (95% CI 21.7–28.0)], p = 0.04. The treated group used less rescue medication with mean AUC 17.7 [SD 10.4 (95% CI 12.9–22.4)] compared to mean AUC 24.3 [SD 6.9 (95% CI 21.1–27.4)] in the placebo group, p = 0.04. The combined symptom and medical score mean AUC 37.1 [SD 16.2 (95% CI 29.9–44.6)] in the treated group was approximately 24% lower than the mean AUC 49.1 [SD 10.1 (95% CI 44.5–53.7)] in the placebo group, p = 0.008 (Fig. (