Sample size calculation
RAP, myocardial ischemia
MYOCARDIAL ISCHEMIA, REFRACTORY ANGINA PECTORIS
Currently, no data with regard to the percentage of myocardial ischemia (as % of the left ventricular myocardium) present in patients with RAP using myocardial perfusion PET scan as imaging modality are available. The data available on this subject is with the imaging modality MIBI‐SPECT. The percentage of myocardial ischemia (as % of the left ventricular myocardium) present in patients with refractory angina pectoris using MIBI‐SPECT ranges from 6.12% (standard deviation of 3.7)Using these clinical assumptions (average percentage of myocardial ischemia of 10% and a standard deviation of 7) and the typical assumptions (paired, two‐tailed Due to the study design using cross‐over, it is theoretically possible that a carry‐over and/or period effect could occur. We will apply the two‐stage approach as proposed by Grizzle et al to assess the carry‐over and period effect.