Urinary PK parameters
nausea and vomiting, SAD
The urinary excretion and PK parameters of MRX-1352, contezolid, and MRX-1320 in subjects receiving IV and oral SAD and multiple doses of contezolid acefosamil are shown in Urine pharmacokinetic parameters of MRX-1352, contezolid, and MRX-1320 in healthy Chinese subjects after intravenous and oral administration of contezolid acefosamilSubject 2B106 was excluded from this PK analysis due to nausea and vomiting on day 11.The data are presented as mean (SD) unless otherwise specified. CL
After IV SAD of 1,000- to 2,000-mg contezolid acefosamil in healthy subjects, the UAThe cumulative urinary excretion rate-time curves of MRX-1352, contezolid, and MRX-1320 after intravenous or oral administration of single ascending dose of contezolid acefosamil. (Urine samples from the subjects were only collected up to 48 h after oral administration of 1,500 mg in healthy subjects. The UA