Discussion
VASODILATION
Endurance performance largely depends on increased oxygenation and blood flow to skeletal muscle [NO-related supplements are growing in popularity; however, to date there is a lack of consensus regarding the effects of L-citrulline and L-arginine on aerobic exercise performance [Due to the role of NO in vasodilation and improvements in blood circulation, many studies have investigated the mechanisms of NO-related supplements on aerobic exercise performance [In addition to vasodilation, NO promotes increases in blood flow enhancing nutrient, hormone, and oxygen delivery to exercising muscles [Nitrates and nitrites have consistently been used as indicators of NO status, as a result of the rapid metabolism of L-arginine and L-citrulline [Previous research in recreationally trained individuals has demonstrated that L-citrulline supplementation may improve aerobic performance markers such as TTE and aerobic capacity [