Statistical analysis
dSS, dMS and dCSMS were expressed as the area under the curve (AUC) and the differences between the groups were calculated using a Mann–Whitney test. A Wilcoxon matched-pairs signed rank test was performed on SNOT-22 and Juniper RQLQ when comparing day 1–21. A Mann–Whitney test was used to analyze the individual difference day 1–21 between the groups.In a time-series analysis a generalized additive model (GAM) was used to evaluate the relative risk (RR) for symptoms in the study group.