Analytical methods
Plasma and urine samples were analyzed to measure concentrations of baxdrostat and its primary metabolite (CIN-107-M), aldosterone and its precursors, cortisol and its precursor, and ACTH using a validated liquid chromatography tandem mass spectrometry method (LC-MS/MS). The quantifiable ranges for both baxdrostat and its metabolite CIN-107-M in plasma and urine were 0.05 to 50 ng/mL (low range) and 5 to 2500 ng/mL (high range), using baxdrostat-d