Univariate and Multivariate Survival Analyses
myocardial infarction/coronary artery disease, Arousals, stroke, asthma, mean heart rate, mean respiratory rate, asthma, atrial fibrillation, apnea-hypopnea, COPD, diabetes
TRANSIENT ISCHEMIC ATTACK, ATRIAL FIBRILLATION, STROKE, PARKINSON DISEASE, COPD, CONGESTIVE HEART FAILURE, ASTHMA, REGRESSION, HYPERTENSION, DIABETES
Although prearousal QTVi was not significantly associated with mortality outcomes (QTVi and mortality. All-cause mortality across QTVi quartiles at baseline (A), arousal onset (C), and postarousal onset (E). Cumulative incident function curves comparing the competing risk of CV and non-CV mortality of dichotomized QTVi at baseline (B), arousal onset (D), and postarousal onset (F). QTVi values were dichotomized using the fourth quartile of the arousal onset QTVi distribution. P value shows log-rank test results. CV = cardiovascular; Q1-Q4 = quartiles of the QT variability index for Baseline QTVi, Arousal onset QTVi and Post Arousal onset QTVi; QTVi = QT variability index.We developed univariate and multivariable Cox proportional regression models for QTVi prior to, during, and following arousal onset to assess associations with all-cause, CV, and non-CV mortality (Association of QT and RR Time Intervals Variables Prior to, During, and Following Arousals With All-Cause and Cardiovascular MortalityMultivariable analysis was adjusted for age, history of stroke, atrial fibrillation, myocardial infarction/coronary artery disease, congestive heart failure, transient ischemic attack, diabetes, hypertension, COPD, asthma and Parkinson disease, mean heart rate, mean respiratory rate, Physical Activity Scale for Elderly, systolic and diastolic BPs, time of sleep spent below 90% oxygen saturation, BMI, apnea-hypopnea index, arousal index, average corrected QT, arousal burden, and drink and smoking habit. QT variability index (QTVi) values were dichotomized at the 75th percentile of the arousal-onset QTVi. Boldface indicates a The exposure-response analysis shows the nonlinear association of QTVi at arousal with CV mortality adjusted for confounders (The exposure-response relationship of arousal-related QTVi and CV mortality adjusted for age, history of stroke, myocardial infarction/coronary artery disease, atrial fibrillation, congestive heart failure, diabetes, hypertension, COPD, asthma, mean heart rate, mean respiratory rate, Physical Activity Scale for Elderly, systolic and diastolic blood pressures, time of sleep spent below 90% oxygen saturation, BMI, apnea-hypopnea index, arousal index, average corrected QT, arousal burden, and drink and smoking habit. CV = cardiovascular; QTVi = QT variability index.