Roughly east of the Pennsylvania Turnpike overpass in the borough of Plum, PA 380 begins an overlap with the Orange Belt at the intersection with Center Road near Boyce Park. At the New Texas Road junction, the belt turns north and leaves PA 380.
In the hamlet of Rodi, PA 380 meets the northern terminus of PA 791 and begins an overlap with the Yellow Belt. Both routes take a more northern alignment into the northeastern portions of the township.