The New York alignment has remained virtually unchanged since it was assigned as part of the 1930 renumbering of state highways in New York, while the designations of the roads it connects to in Pennsylvania have varied over the years. The two segments of PA 426 were established at different times in the 1940s.
At both crossings of the state line it continues as Pennsylvania Route 426 (PA 426). It is the only other state highway besides NY 440 that can claim the distinction of being a middle segment of another state's similarly-numbered highway.