She died of smallpox on 6 December 1618. None of their children survived to adulthood.
Also around that time, he resigned the title Lord Ramsay of Melrose in favour of his cousin, Sir George Ramsay of Dalhousie. The new Lord Ramsay of Melrose had that title altered to Lord Ramsay of Dalhousie, and is the ancestor of the Earls of Dalhousie.