Toews bounced back during the first half of the 2022–23 season with 14 goals and assists for 28 points in 46 appearances. However, Toews' health deteriorated midway through the season causing him to miss several weeks. He announced on February 19, 2023, that he was still suffering from symptoms of long COVID and CIRS.
He offered no timetable for his return, commenting, "it has reached the point where I had no choice but to step back and concentrate on getting healthy." Toews returned to the Blackhawks' lineup after a two-month absence on April 1. On April 13, Blackhawks general manager Kyle Davidson announced that the team would not re-sign Toews after his contract expired at the end of the season.