Los Andes principal economy is based on mining and agriculture, with vineyards and grapes being the principal fruit export. Copper and other minor minerals production is handled by Codelco Chile.
From 1973 until 2004, the Automotores Franco Chilena S.A. plant assembled Peugeot and Renault automobiles from French and Argentine components in Los Andes. Peugeot production began with the 404 and ended with the 206; Renaults were also produced there between 1979 and 1991.