Originally, it was established as a secondary campus to the Albury campus, however by 2010 that campus closed and the Thurgoona campus had been developed into their sole Albury campus. During late 2010, a new dentistry and oral health campus were completed behind the Thurgoona Plaza.
Charles Sturt University purchased land at Thurgoona in 1993 from the Albury-Wodonga Development Corporation to the value of $6 million. Then in April 1997 construction began on the new Thurgoona campus.