Lesieur played most of his professional hockey career with the Providence Reds of the Canadian–American Hockey League (Can-Am) and the International American Hockey League (IAHL/AHL), where he led the Reds to 3 Fontaine Cup titles and 2 Calder Cup championships as a player, team captain and/or player coach.
Born in Fall River, Massachusetts, in 1931 Lesieur became the first American-born player to have his name engraved on the Stanley Cup as a member of the Montreal Canadiens.