She has two children and currently lives in Paris, where she acts and models. As of 2010, she is a theater actress, charity spokeswoman for the Ghanaian charity OrphanAid Africa, and the face of luxury ad campaigns. In 2007, she released a perfume line under her name with Etat libre d'Orange.
In 2009, she posed nude in an information campaign on breast cancer for the magazine Marie Claire. She was selected to be on the jury for the main competition section of the 2015 Cannes Film Festival. In 2022, Rossy de Palma was appointed UNESCO Goodwill Ambassador for cultural diversity.