State Trunk Highway 101 (often called Highway 101, STH-101 or WIS 101) is a state highway in the U.S. state of Wisconsin. It runs south–north in northeast Wisconsin from US 8 in Armstrong Creek to WIS 70, US 2 and US 141 in Florence.
The highway also serves the community of Fence and the areas surrounding the Pine and Popple rivers. WIS 101 is maintained by the Wisconsin Department of Transportation.