The Cardinals finished 11-6 and made the playoffs as a Wildcard team, seeded 5th, and facing off against their division rival Rams for the 3rd rematch of the season. Arizona lost 34–11 and were eliminated from postseason contention.
Kyler Murray returned to the field in Week 13 and led the Cardinals to a 33–22 victory over the Bears, putting the team at a record of 10–2, but the team then lost 3 straight, falling in close games to the Rams and Colts, but also losing 30–12 to the Lions who previously had only 1 win on the year. In Week 17 the Cardinals beat the Cowboys 25–22, snapping their losing streak, but fell to the Seahawks in the final week of the regular season, and in doing so, lost out on the NFC West title and the 3 seed.