State Route 95 (SR 95) was first designated on May 26, 1936 over a former county road between San Luis and Yuma. On June 20, 1938, SR 95 was extended north through Quartzsite to SR 72 in Bouse.
SR 95 also replaced SR 172 north of Parker. The part of SR 72 northwest of Parker became a spur of SR 95.