Many species are recognized as opportunistic pathogens of man and animals, causing eumycetoma, onychomycosis, and hyalohyphomycosis.
Infections of humans by fungi of this genus are rare, but clinical manifestations of hyalohyphomycosis caused by Acremonium may include arthritis, osteomyelitis, peritonitis, endocarditis, pneumonia, cerebritis, and subcutaneous infection.