On January 1, 1970, NY 2 was truncated to Troy on its western end. Its former routing across the Hudson River to US 4 in southern Troy became an extension of NY 378.
In the early 1940s, NY 2 was extended south from Troy to downtown Albany by way of the bridge. NY 378 was realigned east of NY 377 in the early 1950s to follow a new highway connecting directly to the Troy–Menands Bridge.