The B60 bus route starts at Williamsburg Bridge Plaza near the Marcy Avenue station. After the subway station, buses head north and use a number of streets through the neighborhood, eventually reaching the Morgan Avenue station on the BMT Canarsie Line. Buses then reach Wilson Avenue and run along the street, parallel to the Canarsie Line until it reaches Decatur and Cooper Streets, near the Wilson Avenue station.
South of Brookdale University Hospital and Medical Center, the B60 enters Canarsie and turns onto Rockaway Parkway. At Rockaway Parkway and Glenwood Road is the Rockaway Parkway terminus of the Canarsie Line and a transfer point to several routes, including the B6, B17, B42 and B82. However, like the B17, the B60 does not have its own dedicated loop and northbound buses stop in front of the station entrance, while southbound service stops on Glenwood Rd at the B6 bus stand.