Mannheim Hauptbahnhof (German for Mannheim central station) is a railway station in Mannheim in the German state of Baden-Württemberg. It is the second largest traffic hub in southwestern Germany after Stuttgart Hauptbahnhof, with 658 trains a day, including 238 long-distance trains. It is also a key station in the Rhine-Neckar S-Bahn.
100,000 passengers embark, disembark or transfer between trains at the station each day. The station was modernised in 2001. It is classified by Deutsche Bahn as a category 2 station.