Shortly after her arrival in Kirtland, she met and married Brigham Young. She encountered the widowed Young while he was giving a sermon, and Angell felt "drawn to him" as she listened to him preach. Young was quickly impressed by Angell's spiritual nature and countenance, and the two began their courtship.
The couple secured a marriage license in February 1834, and were legally married on March 31, 1834. The two were later sealed in the Kirtland Temple. Mary Ann Angell and Brigham Young had a total of six children together.