It was first aired on November 6, 2006, making it the first episode to be aired during the November sweeps in the United States. The episode is written by Karyn Usher and directed by Dwight H. Little.
"Rendezvous" features the meeting of the characters, Michael Scofield and Sara Tancredi, for the first time in the second season. The episode takes place on June 3 as revealed in the previous episode.