For , the route heads east, turning to the north again near the southwestern shore of Storm Lake. It continues north past the western shore for  and negotiates an S-curve around the northwestern shore and into the city of Storm Lake.
It heads north through Schaller and through northwest Sac County, crossing into Buena Vista County near mile marker 6. Three miles into Buena Vista County, Iowa 110 turns to the east at Buena Vista County Road C65 (CR C65).