In 1924, WIS 91 was relocated from the Ripon–Oshkosh route to the Merill–McCord route, causing CTH-E to move just northwest of its former route.
The new route traveled from US 51 in Merill to US 8 in McCord along present-day WIS 107, pre-bypass alignment of WIS 10 (after 1926, US 51), and present-day CTH-CC.