The diet prescribes a program for weight loss and longevity based on SIRT-1 gene activation. While calorie restriction in various forms has shown promise in clinical trials, evidence of the long-term effects of such diets is nonexistent.
The diet emphasizes activating the SIRT-1 gene to achieve weight loss and increased lifespan. While calorie restriction has been studied for its potential benefits, there is a lack of data on its long-term effects.