When NC 33 reaches US 264 again, it meets a junction of US 264 Alternate's eastern terminus, and loops south with it as Greenville Boulevard, when NC 33 runs east leaving Greenville, it passes through a road junction with Blackjack-Simpson Road bypassing Simpson on its way to Grimesland, after leaving Grimesland, it meets a road junction with Grimes Farm Road on its way to Beaufort County, when NC 33 bypasses Grimes Farm Road again, it enters Beaufort County, and than meets a road junction with Godley Road.
As NC 33 regains US 264, it reunites with the eastern terminus of US 264 Alternate, and heads south on Greenville Boulevard as NC 33 exits Greenville. It then passes through a bypass that avoids Blackjack-Simpson Road, which skips over Simpson to reach Grimesland. After passing through Grimesland, NC 33 meets up with Grimes Farm Road on its way to Beaufort County, where it then takes a detour around Grimes Farm Road before entering Beaufort County and meeting Godley Road.