The route enters Hopkinton, and turns northeast at an intersection with West Main Street, which provides nearby access to I-495. Route 135 crosses Route 85 just to the east, then continues through Ashland and into Framingham. In downtown Framingham, Route 135 crosses Route 126.
The route begins in Hopkinton and turns northeast at a junction with West Main Street, which provides access to I-495. Route 135 crosses Route 85 east of it before continuing through Ashland and into Framingham. In downtown Framingham, Route 135 intersects Route 126.