Gruffudd is known to have had only one son, Hywel ap Gruffudd ap Cynan ab Owain Gwynedd, who is not known to have had any children of his own and died in 1216.
It is known that Gruffudd had only one son, Hywel ap Gruffudd ap Cynan ab Owain Gwynedd, who did not have any children of his own and passed away in the year 1216.