Certain melanoma cells can use VCAM-1 to adhere to the endothelium, VCAM-1 may participate in monocyte recruitment to atherosclerotic sites, and it is highly overexpressed in the inflamed brain.
In the context of melanoma, certain cells can use VCAM-1 to attach to the endothelial lining, potentially leading to the recruitment of monocytes to areas susceptible to atherosclerosis, and this molecule is notably overexpressed in the inflamed cerebral cortex.