He was appointed the Wehrmacht Commander in southeast Europe on 1 August 1942, and from 28 December 1942 this position was re-designated as Commander-in-chief in southeast Europe. The forces under his command were also designated as Army Group E, and he was appointed as its commander. In this role, Löhr controlled all subordinate commands in southeast Europe, including the commanding general in Serbia (Paul Bader), the military commander in the Salonika-Aegean area (Curt von Krenzki), the military commander in southern Greece, the commander of Crete, the naval commander in the Aegean Sea, the German plenipotentiary general in the Independent State of Croatia, the commanding general of German troops in Croatia, and the military attaché in Sofia, Bulgaria.
On August 1st, 1942, he was appointed as the Wehrmacht Commander in southeast Europe.  This position was later re-designated as Commander-in-chief in southeast Europe on December 28th, 1942. He commanded all subordinate commands in southeast Europe, including the commanding general in Serbia (Paul Bader), the military commander in the Salonika-Aegean area (Curt von Krenzki), the military commander in southern Greece, the commander of Crete, the naval commander in the Aegean Sea, the German plenipotentiary general in the Independent State of Croatia, the commanding general of German troops in Croatia, and the military attaché in Sofia, Bulgaria.