Recalled when rosters expanded, Medders pitched seven more innings for the Diamondbacks, allowing just one more home run. In 30 games for Arizona, he had a 1–2 record, a 4.30 ERA, 23 strikeouts, 16 walks, and 30 hits allowed in  innings. He did not pitch in the playoffs for the Diamondbacks, who won the National League (NL) West and swept the Chicago Cubs in the 2007 National League Division Series before getting swept by the Rockies in the 2007 National League Championship Series.
Recalled as rosters expanded, Medders threw seven more innings for the Diamondbacks, permitting just one additional home run. In 30 games for Arizona, he had a 1–2 record, an ERA of 4.30, 23 strikeouts, 16 walks, and 30 hits allowed in innings. He did not pitch in the playoffs for the Diamondbacks, who won the National League (NL) West and swept the Chicago Cubs in the 2007 National League Division Series before being swept by the Rockies in the 2007 National League Championship Series.