The regulation of PDE1 by Ca2+ and CaM has been studied in vitro and these studies have shown that eight methionine residues within the hydrophobic clefts of Ca2+-CaM are required for the binding and activation of PDE1.
The regulation of PDE1 by Ca2+ and CaM has been studied in vitro, and these studies have demonstrated that eight methionine residues within the hydrophobic clefts of Ca2+-CaM are necessary for binding and activating PDE1.