Common to all members of the penicillin class of drugs, oxacillin may cause acute or delayed hypersensitivity reactions. As an injection, oxacillin may cause injection site reactions, which may be characterized by redness, swelling, and itching.
Oxacillin, like other penicillins, may provoke allergic responses in its recipients, which can be rapid or slow in onset. As an injectable form, oxacillin can cause skin irritation at the injection site, marked by inflammation, swelling, and pruritus.