This class is thought to guide the sites of modification of uridines to pseudouridines by forming direct base pairing interactions with substrate RNAs. Targets may include ribosomal and spliceosomal RNAs but the exact functions of many snoRNAs, including U19, are not confirmed.
This class is believed to play a role in positioning modifications on uridine residues within RNAs by forming direct base pairings with substrate RNAs. Potential targets include ribosomal and spliceosomal RNAs; however, the specific functions of many snoRNAs, such as U19, remain unclear.