The oldest piece of the line is the part closest to Columbus; the Columbus, Piqua and Indiana Railroad opened from Columbus to Union City, Indiana (on the state line) in 1853 and 1854 to Piqua and 1859 to Union City.
The initial section of the railroad line is nearest to Columbus; the Columbus, Piqua and Indiana Railroad established routes from Columbus to Union City, Indiana (at the border with a neighboring state) in 1853 and 1854 to Piqua and 1859 to Union City.