The evidence also indicates a reduction of oral mucositis in adults receiving high-dose melphalan-based cancer treatment prior to haematopoietic stem cell transplantation, although there is uncertainty regarding the size of the reduction in this instance. No evidence was found for use of this preventive measure in children.
This research suggests that high-dose melphalan-based chemotherapy prior to bone marrow transplant can reduce oral mucositis in adults, but more research is needed to determine the extent of this effect. There's no evidence supporting its use in children.