The papillomavirus life cycle begins with cells actively multiplying in epithelial cells of basal and parabasal layers. The differentiation of these cells is necessary for this virus to complete its life cycle. Transforming proteins E6 and E7 induce the S-phase in the lower epithelial layers.
The papillomavirus lifecycle initiates when cells are actively dividing in basal and parabasal layers of epithelial cells. This differentiation is crucial for the virus's completion. Proteins E6 and E7 promote the S-phase in lower epithelial layers.