Protein arginine N-methyltransferase-4 (PRMT4/CARM1) methylation of arginine residues within proteins plays a critical key role in transcriptional regulation (see the PRMT4 pathway on the left). PRMT4 binds to the classes of transcriptional activators known as p160 and CBP/p300.
The methylation of arginine residues by PRMT4 (CARM1) has a significant impact on transcriptional regulation, which is closely related to the PRMT4 pathway shown on the left. PRMT4 also interacts with certain transcriptional activators, such as p160 and CBP/p300.