Later, as a result of the yellow fever epidemic that struck Galveston, the St. Mary's Orphanage was started, first in the hospital, and was later moved just outside town, away from the epidemic. This epidemic also struck two of the sisters: Mother Mary Blandine would die of yellow fever on August 18, 1867; Sister Mary Ange also contracted yellow fever but recovered and returned to France.
The yellow fever outbreak in Galveston led to the establishment of the St. Mary's Orphanage, initially within the hospital and later relocated outside town for safety. This epidemic also affected two sisters: Mother Mary Blandine died from yellow fever on August 18, 1867; Sister Mary Ange recovered from the illness and returned to France.