The melanosomes can now continue on their path towards the cell periphery. If either Rab27, Slac2A or myosin Va are absent then the melanosomes remain in the perinuclear region of the cell.
In this scenario, the melanosomes have reached a point where they can continue their path to the cell's edge. Nevertheless, if certain proteins (Rab27, Slac2A, or myosin Va) are not present, they will remain in the perinuclear area of the cell.