The expression of PUMA is regulated by the tumor suppressor p53. PUMA is involved in p53-dependent and -independent apoptosis induced by a variety of signals, and is regulated by transcription factors, not by post-translational modifications.
PUMA's expression is influenced by the tumor suppressor p53. PUMA is involved in apoptosis induced by different types of stimuli, whether mediated by p53 or not, and this regulation does not depend on post-translational modifications but rather on transcription factors.