Part of the Kelem Welega Zone, Anfillo is bordered on the southwest by the Gambela Region, on the north by Jimma Gidami, on the northeast by Yemalogi Welele, and on the east by Sayo.
Part of the Kelem Welega Zone, Anfillo is bordered by the Gambela Region to the southwest, Jimma Gidami to the north, Yemalogi Welele to the northeast, and Sayo to the east.