Saga played an important role in the Meiji Restoration, alongside the domains of Tosa, Satsuma, and Chōshū, and samurai from the domain fought the shogunate at the battle of Ueno and in other clashes of the Boshin War. As a result, the new Meiji government which emerged afterwards featured a number of figures from Saga, including Etō Shinpei, Ōkuma Shigenobu, Ōki Takatō, and Sano Tsunetami.
Saga was instrumental in the Meiji Restoration, working alongside domains of Tosa, Satsuma, and Chōshū, with samurai from Saga engaging in battles against the shogunate at Ueno and other conflicts during the Boshin War. This led to a new Meiji government emerging, which included prominent figures such as Etō Shinpei, Ōkuma Shigenobu, Ōki Takatō, and Sano Tsunetami.