The line runs from New Castle, Pennsylvania west through Youngstown and Akron to Greenwich, Ohio along a former Baltimore and Ohio Railroad line. Its east end is near Mahoningtown, at the west end of the New Castle Terminal Subdivision.
Beginning in New Castle, Pennsylvania, the route proceeds westward through Youngstown and Akron before reaching Greenwich, Ohio, following an old Baltimore and Ohio Railroad path. The eastern endpoint is near Mahoningtown, which signifies the western boundary of the New Castle Terminal Subdivision.