Edwards ran for a full term in November 2008, defeating Republican candidate Peter James with 85% of the vote. She ran for U.S. Senate in 2016 in the primary to replace retiring Barbara Mikulski instead of running for re-election to her Congressional seat but was defeated by Congressman Chris Van Hollen in the Democratic primary.
Edwards engaged in a full-term campaign in November 2008, defeating Republican candidate Peter James with an overwhelming majority of 85% of the vote. She pursued a Senate seat in 2016 as part of the primary election to replace retiring Senator Barbara Mikulski instead of seeking re-election to her congressional position but was defeated by Congressman Chris Van Hollen.