These two proteins homeostatically control miRNA biogenesis by an auto-feedback loop. A 2nt 3' overhang is generated by Drosha in the nucleus recognized by Dicer in the cytoplasm, which couples the upstream and downstream processing events.
Two proteins regulate miRNA biogenesis through an auto-feedback loop involving Drosha and Dicer. The process involves a specific sequence of events that occurs within the nucleus and cytoplasm.