SH-45 begins at the US-281/SH-14 junction in Waynoka. The first  of SH-45 heading east out of Waynoka is concurrent with US-281.
The SH-45 route begins at the intersection of US-281 and SH-14 in Waynoka.  The first portion of SH-45 that heads east out of Waynoka runs alongside US-281.