Meredith is the narrator of the show and serves as the focal point for most episodes, although the audience receives perspectives from other characters as well. Pompeo's connection with Patrick Dempsey (Derek Shepherd) is acclaimed as a high point of the series.
The show features Meredith as its central character, with her perspective driving most episodes. Other characters are included in the narrative but primarily serve to provide additional perspectives. The relationship between Pompeo and Patrick Dempsey (Derek Shepherd) is considered a significant highlight of the series.