He served as Minister for Trade in the 1961–1963 Konstantinos Karamanlis cabinet and, following Karamanlis' resignation and self-exile, Pipinelis served briefly as an interim Prime Minister of Greece from 17 June 1963 to 29 September 1963. On 20 November 1967 he was appointed as Minister of Foreign Affairs during the dictatorship.
Pipinelis served as Trade Minister under Konstantinos Karamanlis from 1961 to 1963. Following Karamanlis' departure and self-imposed exile, Pipinelis briefly filled in as interim Prime Minister of Greece until September 29, 1963. He later took on the role of Foreign Minister in November 20, 1967, during a period of authoritarian rule.