In humans, the role of HP1 on splicing has been characterized for alternative splicing of the EDA exon from the fibronectin gene. In this pathway HP1 acts as a mediator protein for repression of alternative splicing of the EDA exon.
In human cells, the function of HP1 has been studied in the context of RNA processing and alternative splicing, specifically for the inclusion or exclusion of exons like the EDA exon from the fibronectin gene. In this pathway, HP1 acts as a regulatory protein to modulate the splicing process.