In line with its dopaminergic neurotoxicity, methamphetamine use is associated with a higher risk of Parkinson's disease. In addition to its dopaminergic neurotoxicity, a review of evidence in humans indicated that high-dose methamphetamine use can also be neurotoxic to serotonergic neurons.
Methamphetamine's impact on the brain, specifically its dopaminergic toxicity, increases the likelihood of developing Parkinson's disease. Additionally, studies in humans indicate that excessive methamphetamine use can also harm serotonin-producing cells.