In 2005, a study was conducted about the show's impact on AIDS education in South Africa; it found that viewers exposed to Takalani Sesame demonstrated more knowledge and awareness about HIV, AIDS, and its treatment.
In 2005, a study was conducted about the impact of "Takalani Sesame" on educating people about HIV/AIDS in South Africa; it revealed that those who watched the show acquired more knowledge and awareness about these topics.