Upon activation by its ligand agrin, MuSK signals via the proteins called Dok-7 and rapsyn, to induce "clustering" of acetylcholine receptors (AChR). Cell signaling downstream of MuSK requires Dok-7.
When activated by its ligand agrin, the protein MuSK triggers a process that causes acetylcholine receptors (AChRs) to cluster together. This process relies on proteins called Dok-7 and rapsyn.