Ishiwata's research interests go beyond the mechanical and physiological import of SPOC to bio-motile systems focusing on the structural and functional hierarchy from single molecules (myosin, kinesin, actin) to macromolecular assemblies (myofibrils, meiotic spindle and cells (cardiac, HeLa, etc.).
Ishiwata's research investigates the hierarchical structure of SPOC in bio-motile systems, ranging from single molecules like myosin, kinesin, and actin to macromolecular assemblies such as myofibrils, meiotic spindles, and various cell types (cardiac, HeLa).