It runs from the village of Catskill to the village of Coxsackie, serving as an alternate route of U.S. Route 9W between the two locations. While US 9W follows a more inland routing, NY 385 runs along the Hudson River and serves the village of Athens.
From Catskill to Coxsackie, NY 385 functions as an alternative route for U.S. Route 9W. On the other hand, US 9W travels inland, while NY 385 follows the Hudson River and serves the village of Athens.