Within each RAR subtype there are various isoforms differing in their N-terminal region A. Multiple splice variants have been identified in human RARs: four for , five for , and two for . As with other type II nuclear receptors, RAR heterodimerizes with RXR and in the absence of ligand, the RAR/RXR dimer binds to hormone response elements known as retinoic acid response elements (RAREs) complexed with corepressor protein.
Within each subtype of retinoid-acid receptor (RAR), there are various isoforms that differ in their N-terminal region A. Multiple splice variants have been identified in human RARs: four for , five for , and two for . As with other type II nuclear receptors, RAR heterodimerizes with RXR, and when unbound to a ligand, the RAR/RXR dimer binds to hormone response elements known as retinoic acid response elements (RAREs) complexed with corepressor protein.