After crossing under the tracks, NY 112 continues northeast through Medford, entering interchange 64 of the Long Island Expressway (I-495) and expanding to four lanes once again before an intersection with CR 16 (Horse Block Road). The route returns to two lanes after CR 16, passing east of Blue Ridge Golf Club and Holy Sepulchre Cemetery. At this point, NY 112 changes names from Medford Avenue to Port Jefferson–Patchogue Road.
Following the tracks, NY 112 continues northeast through Medford, merging into interchange 64 of the Long Island Expressway (I-495) and increasing to four lanes before crossing CR 16 (Horse Block Road). The road then narrows back to two lanes after passing east of Blue Ridge Golf Club and Holy Sepulchre Cemetery. At this point, NY 112 transitions from Medford Avenue to Port Jefferson–Patchogue Road.