(2004) found that intravenous THC produced effects that resemble schizophrenia in both the positive symptoms (hallucinations, delusions, paranoia, and disorganized thinking) and negative symptoms (avolition, asociality, apathy, alogia, and anhedonia). Certain strains of cannabis may be more psychotomimetic than others, probably due to the action of cannabidiol (CBD), which inhibits P450 3A11's metabolic conversion of THC to 11-Hydroxy-THC, which is four times more psychoactive.p.
(2004) discovered that intravenous THC produced effects similar to schizophrenia, encompassing both positive symptoms (hallucinations, delusions, paranoia, and disorganized thinking) and negative symptoms (avolition, asociality, apathy, alogia, and anhedonia). Certain cannabis strains might be more psychotomimetic than others, likely because of the influence of cannabidiol (CBD), which blocks P450 3A11's metabolic conversion of THC to 11-Hydroxy-THC, making it four times more psychoactive.