The malfunctions in CSNB1 specifically affect the ON pathway, by hindering the ability of ON-type bipolar cells to detect neurotransmitter released from photoreceptors. Rods, which are responsible for low-light vision, make contacts with ON-type bipolar cells only, while, cones, which are responsible for bright-light vision, make contacts with bipolar cells of both ON an OFF subtypes.
The malfunctions in CSNB1 specifically impact the ON pathway by hindering the detection of neurotransmitter from photoreceptors by ON-type bipolar cells. Rods, responsible for low-light vision, make connections only with ON-type bipolar cells, while cones, associated with bright-light vision, connect to both ON and OFF subtype bipolar cells.