Brudenell was Member of Parliament for Shaftesbury from 1754 to 1761, for Hastings from 1761 to 1768, for Great Bedwyn from March to November 1768 and for Marlborough 1768 to 1780.
Brudenell held the office of Member of Parliament in various constituencies between 1754 and 1780, including Shaftesbury, Hastings, Great Bedwyn, and Marlborough.