Tucci is best known for playing the T-Birds member Sonny LaTierri in the 1978 film version of the musical Grease. He portrayed law student Gerald Golden in the TV series The Paper Chase from 1983 to 1986. He then played best friend Pete Schumaker on It's Garry Shandling's Show (1986–1990).
Tucci is known for his roles in films and television shows that feature characters within specific social contexts: Sonny LaTierri (Grease), Gerald Golden (The Paper Chase), and Pete Schumaker (It's Garry Shandling's Show).