Within the hippocampus, the CRHR1s are most abundant, residing mainly on the pyramidal cells of CA1 and CA3. Chronic activation of CRHR1s by CRH induced by early life stress has been shown to underlie memory deficits and learning impairments and anxiety in adulthood.
The hippocampus contains a high concentration of CRHR1 receptors, mainly situated on the pyramidal cells of CA1 and CA3 regions. Chronic exposure to CRH, triggered by early life stress, has been linked to cognitive and emotional impairments, including memory deficits, learning difficulties, and anxiety in adulthood.