After oral administration of 50 mg of buformin to volunteers, almost 90% of the applied quantity was recovered in the urine; the rate constant of elimination was found to be 0.38 per hr. Buformin is a strong base (pKa = 11.3) and not absorbed in the stomach.
Following ingestion, nearly all of the buformin dose was excreted through urine; the elimination rate was determined to be 0.38 per hour. Buformin is a highly alkaline compound (pKa = 11.3) that does not get absorbed in the stomach.