The route enters the town of Cheswold, where it becomes Main Street. The road passes homes and some businesses in the town, crossing the Delmarva Central Railroad's Delmarva Subdivision line at-grade. DE 42 reaches an intersection with US 13 on the eastern edge of Cheswold at Bishops Corner.
The route enters the town of Cheswold, where it becomes a main street. The road passes homes and businesses in the town, crossing the Delmarva Central Railroad's rail line at-grade. DE 42 intersects US 13 on the eastern edge of Cheswold at Bishops Corner, highlighting its connection to the local community.