Cleavage at the CFCS separates the mature protein from the EHP, allowing it to incorporate into nascent ZP filaments. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus; however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome.
Cleavage at the CFCS separates the mature protein from the EHP, allowing it to be incorporated into nascent ZP filaments. A variation in the last exon of this gene once supported an additional ZP3 locus; however, sequence and literature review indicate that there is only one full-length ZP3 locus in the human genome.