DSBs accumulate in neurons and astrocytes of the hippocampus and frontal cortex at early stages and during the progression to Alzheimer's disease, a process that could be an important driver of neurodegeneration and cognitive decline.
Amyloid plaques build up in neurons and astrocytes of the hippocampus and frontal cortex at early stages and throughout the development of Alzheimer's disease, potentially driving neuronal degeneration and cognitive deterioration.