In tissues with high energetic demands, oxygen is rapidly consumed, which increases the concentration of H+ and carbon dioxide. Through the Bohr effect, hemoglobin is induced to release more oxygen to supply cells that need it. In contrast, 2,3-BPG has no effect on the related compound myoglobin.
In tissues with high energy requirements, oxygen is quickly used up, which raises the concentration of H+ and carbon dioxide. Through the Bohr effect, hemoglobin is prompted to release more oxygen to meet cells' needs. In contrast, 2,3-BPG does not influence the related compound myoglobin.