East of the intersection with CR S70, the highway traveled southeast towards St. Ansgar. It entered  St. Ansgar along Main Street, before turning east on Fourth Street. Iowa 105 crossed a Canadian National Railway line before ending at U.S. Route 218 just  later.
East of CR S70's junction, the highway headed southeast towards St. Ansgar and entered the city along Main Street. It then turned east onto Fourth Street. Iowa 105 crossed a Canadian National Railway line before merging with U.S. Route 218 shortly after.