Infusion of Ucn2 into rat hearts resulted in an immediate and significant improvement in left ventricle function, increased coronary flow, significantly altered intracellular calcium handling and increased SR calcium. These relaxation effects can be explained by the increased calcium clearance into the SR would assist in relaxation of the cell.
Ucn2 infusion led to a marked improvement in heart function and increased blood flow to the heart, which can be attributed to its impact on the cell's ability to relax, resulting from enhanced calcium removal from the cell.