Known for most of its length as Plantation Road, the state highway runs  from U.S. Route 221 (US 221), US 460, and US 220 Alternate in Roanoke north to Interstate 81 (I-81) and US 220 near Hollins.
The road, formerly known as Plantation Road, runs from U.S. Route 221 (US 221), US 460, and US 220 Alternate in Roanoke north to Interstate 81 (I-81) and US 220 near Hollins.