Upon returning to New York City Barnes wrote articles and published works concerning his experiences in the United States. He also started his wholesale drug business in New York City in 1853 and was highly prosperous as a patent medicine manufacturer.
After returning to New York City, Barnes engaged in writing articles and publishing works based on his time spent in the United States. He also established a successful wholesale drug business in New York City in 1853, which was driven by his success as a patent medicine manufacturer.