IRF3 was originally discovered as a homolog of IRF1 and IRF2. IRF3 has been further characterized and shown to contain several functional domains including a nuclear export signal, a DNA-binding domain, a C-terminal IRF association domain and several regulatory phosphorylation sites.
IRF3 was initially recognized as a counterpart of IRF1 and IRF2. Further investigation has shown that IRF3 contains several functional domains, including a nuclear export signal, a DNA-binding region, an association domain at the C-terminus, and regulatory phosphorylation sites.