Loja Canton is located in the southeast of the Province of Loja bordering the Podocarpus National Park and the Province of Zamora-Chinchipe in the east and south, and the cantons of Saraguro in the north, Catamayo, Gonzanama, and Quilanga in the west.
In the southeastern part of Loja Province, Loja Canton is situated near the Podocarpus National Park and Zamora-Chinchipe Province, with Saraguro Canton to its north and Catamayo, Gonzanama, and Quilanga Cantons to its west.