Runge served as home plate umpire for White Sox pitcher, Philip Humber's perfect game on April 21, 2012, at Safeco Field, and the combined no-hitter of Seattle Mariners pitcher Kevin Millwood and five relievers on June 8, 2012, also at Safeco Field, becoming the 10th Major League umpire to call balls and strikes for multiple no-hitters in the same season.
Runge officiated as home plate umpire for White Sox pitcher Philip Humber's perfect game on April 21, 2012, at Safeco Field, and the combined no-hitter of Seattle Mariners pitcher Kevin Millwood and five relievers on June 8, 2012, also at Safeco Field, becoming the 10th Major League umpire to call balls and strikes for multiple no-hitters in the same season.