Nevertheless, since the CD-loop is quite flexible, the monomeric and polymerigenic forms are fully interconvertible, and one state can be favored over the other by altering the redox environment of the protein. Polymerization of PAI-2 occurs spontaneously under physiological conditions, for instance in the cytosol of placental cells.
The CD-loop's flexibility allows for conversion between monomeric and polymerigenic forms, which are influenced by changes in the protein's redox environment. PAI-2 polymerization occurs naturally under physiological conditions, such as within the cytosol of placental cells.