PITPNM3 is a CCL18 receptor, but PITPNM3 is only expressed on breast cancer cells and not on T-cells nor B-cells, and PITPNM3-CCL8 binding induces Pyk2 and Src mediated signaling, a cancer related signaling pathway, and subsequent metastasis of breast cancer.
PITPNM3 functions as a receptor for CCL18, but its expression is limited to breast cancer cells, whereas T-cells and B-cells do not express it. The binding of PITPNM3-CCL8 triggers Pyk2 and Src-mediated signaling, which contributes to the spread of breast cancer.