Since NMDA receptors Dysfunction has been suggested as one of the promising hypotheses for the pathophysiology of schizophrenia, it has been shown that underexpression of this enzyme is an indicator, especially for the paranoid subtype.
NMDA receptor malfunction has been suggested as a possible underlying cause of schizophrenia. Studies have found that reduced activity of this enzyme is an indicator, particularly relevant to the paranoid subtype of the disease.