Vasopressin regulates water excretion from the kidney by increasing the osmotic water permeability of the renal collecting duct – an effect that is explained by coupling of the V2R with the Gs signaling pathway, which activates cAMP. The V2R continues to activate Gs after being internalized by β-arrestin rather than being desensitized.
Vasopressin controls water excretion from the kidney by enhancing the osmotic water permeability of the renal collecting duct – a mechanism explained by the coupling of V2R with the Gs signaling pathway, which triggers cAMP. The V2R continues to activate Gs after internalization via β-arrestin rather than being desensitized.