As a consequence of DAT uptake, amphetamine produces competitive reuptake inhibition at the transporter. Upon entering the presynaptic neuron, amphetamine activates  which, through protein kinase A (PKA) and protein kinase C (PKC) signaling, causes DAT phosphorylation.
The consequence of DAT uptake is that amphetamine inhibits reuptake by competing with it at the transporter. Once inside the presynaptic neuron, amphetamine triggers a cascade of events involving PKA and PKC, leading to DAT phosphorylation.