Finally, 11,12-EET has been shown to relax the internal mammary artery in women, indicating that at least this EET has direct vasodilating actions in humans. On the other hand, several studies in humans with single nucleotide polymorphism in CYP epxoygenase genes have given negative or confusing results.
Ultimately, 11,12-EET has been demonstrated to unwind the internal mammary artery in women, suggesting that at least this EET possesses direct vasodilating effects in humans. Conversely, several studies in humans with a single nucleotide variation in CYP oxygenase genes have yielded inconclusive or conflicting results.