Some of the main problems associated with decreased contractility in those with heart failure are issues arising from imbalances in the concentration of calcium. Calcium permits myosin and actin to interact which allows initiation of contraction within the cardiomyocytes.
Several key problems related to diminished contractility in individuals with heart failure involve imbalances in calcium levels. Calcium is necessary for the interaction between myosin and actin, which initiates contractions within cardiomyocytes.