Further Siglecs have been identified including Siglec-14 and Siglec-15. Siglecs have been characterized into two distinct groups: the first and highly conserved-across-mammals group composed of Sialoadhesins, CD22, MAG, and Siglec-15, and a second group comprising Siglecs closely related to CD33. Others such as Siglec-8 and Siglec-9 have homologues in mice and rats (Siglec-F and Siglec-E respectively in both).
Further Siglecs have been identified, including Siglec-14 and Siglec-15. Siglecs are divided into two main groups: the first group is highly conserved across mammals and includes Sialoadhesins, CD22, MAG, and Siglec-15; the second group consists of Siglecs closely related to CD33. Other examples like Siglec-8 and Siglec-9 have homologues in mice and rats (Siglec-F and Siglec-E respectively).