Pharmacokinetic data of oral trifluridine have only been evaluated in combination with tipiracil, which significantly affects biotransformation of the former. At least 57% of trifluridine are absorbed from the gut, and highest blood plasma concentrations are reached after two hours in cancer patients.
The pharmacokinetics of oral trifluridine have only been studied in combination with tipiracil, which substantially affects how it's metabolized.  Around 57% of trifluridine is absorbed from the gut, and its peak blood plasma levels are reached after two hours in cancer patients.