Unlike Urocortin I, and similar to Urocortin II, Urocortin III is highly selective for the CRF2 receptor and does not show affinity for the CRF binding protein.
In contrast to Urocortin I, which had a different interaction profile, Urocortin III shares similarities with Urocortin II in its selective binding to the CRF2 receptor while differing from it in its lack of interaction with the CRF binding protein.