Mizizios accompanied Emperor Constans II (r. 641–668 A.D) in his Italian and Sicilian expedition. When Constans was murdered in Syracuse, Sicily, in 668 A.D, Mizizios was proclaimed emperor against his will.
Mizizios accompanied Emperor Constans II on his Italian and Sicilian expedition. Following Constans's murder in Syracuse, Sicily, in 668 A.D., Mizizios was unexpectedly proclaimed emperor.