One study found that NPC1 mRNA levels were increased in both fat depots, enriched in fat cells, and down-regulated by weight loss. This gene also interacts with diets consisting of high fats to increase weight gain through “differential regulation of central energy metabolism pathways.” Specifically, presence of this gene showed significantly increased glycolysis and lipogenesis (which involve turning excess glucose or carbohydrates into fats).
A study found that NPC1 mRNA levels were elevated in both fat stores, concentrated within fat cells, and reduced by weight loss. This gene also interacts with diets rich in fats to increase weight gain through "differential regulation of central energy metabolism pathways." Specifically, the presence of this gene was associated with increased glycolysis and lipogenesis.