Maryland Route 392 (MD 392) is a state highway in the U.S. state of Maryland. The state highway runs  from MD 16 in East New Market east to the Delaware state line at Reliance, where the highway continues east as Delaware Route 20 (DE 20).
Maryland's Route 392 spans across the state of Maryland, stretching from its intersection with Route 16 in East New Market towards the Delaware border at Reliance. The road then merges into Delaware's Route 20.