Each new strain is given a unique number and registered with the U.S. EPA and allowances may be given for genetic modification depending on "its parental strains, the proposed pesticide use pattern, and the manner and extent to which the organism has been genetically modified".
The process of registering new strains and granting permits for genetic modification are governed by the U.S. EPA, with approval contingent upon factors such as the strain's parentage, its planned use of pesticides, and the degree of genetic alteration.