The road enters New Garden Township and comes to a partial cloverleaf interchange with Limestone Road, which heads south to the Delaware border and becomes DE 7. PA 41 continues northwest through more rural areas with some homes and businesses, crossing Newark Road and passing a weigh station on the southbound side that serves trucks from both directions. Then route heads into the borough of Avondale, where it crosses an East Penn Railroad line at-grade and comes to an intersection with Baltimore Pike.
The road enters New Garden Township and connects to Limestone Road via a partial cloverleaf interchange. Limestone Road leads south towards Delaware and becomes DE 7. PA 41 continues northwest through rural areas, passing Newark Road and a weigh station serving trucks from both directions before entering Avondale.  At Avondale, the route crosses an East Penn Railroad line at-grade and intersects Baltimore Pike.