Lysosomal perforation and other endomembrane damage can be inflicted by various agents such as some chemicals yielding osmotically active products,  crystalline silica,  possibly amyloid aggregates and cytoplasmic organic or inorganic crystals, as well as intracellular microbial pathogens such as Mycobacterium tuberculosis; such injury can be modeled using membrane-permeant dipeptide precursors that polymerize in lysosomes,.
Lysosomal disruption and other endomembrane damage can result from various agents including chemicals producing osmotically active substances, crystalline silica, possibly amyloid aggregates or cytoplasmic organic/inorganic crystals, as well as intracellular microbial pathogens such as Mycobacterium tuberculosis; this type of injury can be replicated using membrane-permeable dipeptide precursors that polymerize within lysosomes.