In north-central Des Moines, it intersects US 69 and I-235. In northeast Des Moines, it turns to the northeast along Hubbell Avenue, which takes US 6 to Altoona.
In the northern part of Des Moines, Interstate 235 crosses paths with US Highway 69 and Interstate 235. Moving eastward in Des Moines, it follows Hubbell Avenue, a route that leads to US Highway 6 and the town of Altoona.