In 1831, he relocated to Edo to continue his studies in western medicine, returning to Nagasaki in 1836 to study under the Dutch doctor Erdewin Johannes Niemann, despite the Tokugawa shogunate's strict national isolation policy.
In 1831, he relocated to Edo for further medical training, and returned to Nagasaki in 1836 to learn from Dutch physician Erdewin Johannes Niemann, despite the Japanese government's restrictions on foreign contact.