With the entry of the United States into World War I Du Pont was recommissioned 9 April 1917 and assigned to duty in the 2d Naval District. The following year she was attached to Patrol Squadron, New London Section, for duty in Narragansett Bay.
When the United States joined World War I, Du Pont resumed its naval duties on 9 April 1917 and was assigned to service within the 2d Naval District. The following year, she worked with Patrol Squadron, New London Section, for maritime patrols in Narragansett Bay.