Therefore, it is not surprising that NFAT2 lymphocytes specific ablation causes a defect of the BCR-mediated proliferation but whether this phenotype is caused by sole dysregulation of Tfh or B cells or combination of both is uncertain.
The observation that NFAT2 lymphocyte ablation causes a defect in BCR-mediated proliferation but the precise cause (sole dysregulation of Tfh cells or B cells, or a combination) is unclear.