Maitotoxin can indirectly activate calcium-binding proteases calpain-1 and calpain-2, contributing to necrosis. The toxicity of maitotoxin in mice is the highest for nonprotein toxins: the LD50 is 50 ng/kg.
Maitotoxin's mechanism of action involves the activation of calcium-binding proteases calpain-1 and calpain-2, which contributes to cell death. Maitotoxin's toxicity in mice is exceptional among non-protein compounds, with an LD50 of 50 ng/kg.