Based on the 2007 national census conducted by the Central Statistical Agency of Ethiopia (CSA), this woreda has a total population of 125,028, an increase of 97,237 over the 1994 census, of whom 61,977 are men and 63,051 women; 10,526 or 8.42% are urban inhabitants. With an area of 2,685.12 square kilometers, Medebay Zana has a population density of 46.56 people per square kilometer, which is greater than the Zone average of 40.21.
According to the 2007 national census conducted by the Central Statistical Agency of Ethiopia (CSA), this woreda's population reached 125,028, an increase of 97,237 from the 1994 census.  The population is comprised of 61,977 men and 63,051 women, with 10,526 individuals residing in urban areas. The woreda covers 2,685.12 square kilometers and has a population density of 46.56 people per square kilometer, exceeding the Zone average of 40.21.