The TAPBP gene encodes a transmembrane glycoprotein that mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction facilitates optimal peptide loading on the MHC class I molecule.
The TAPBP gene generates a transmembrane glycoprotein that facilitates the interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), essential for transporting antigenic peptides across the endoplasmic reticular membrane. This interaction ensures optimal peptide loading onto MHC class I.