Upon binding to Ca2+, this motif may undergo conformational changes that enable Ca2+-regulated functions as seen in Ca2+ effectors such as calmodulin (CaM) and troponin C (TnC) and Ca2+ buffers such as calreticulin and calbindin D9k.
The binding of this motif to calcium ions leads to conformational changes that enable functions regulated by calcium, including those carried out by proteins such as calmodulin (CaM) and troponin C (TnC), and Ca2+ buffers like calreticulin and calbindin D9k.