Examples of the F-BAR domain family are CIP4/FBP17/Toca-1, Syndapins (also called PACSINs) and muniscins. Gene knock-out of syndapin I in mice revealed that this brain-enriched isoform of the syndapin family is crucial for proper size control of synaptic vesicles and thereby indeed helps to define membrane curvature a physiological process. Work of the lab of Britta Qualmann also demonstrated that syndapin I is crucial for proper targeting of the large GTPase dynamin to membranes.
The F-BAR domain family includes CIP4/FBP17/Toca-1, Syndapins (also called PACSINs) and muniscins.  A study on mice showed that syndapin I, a brain-specific isoform of the syndapin family, is essential for regulating the size of synaptic vesicles and defining membrane curvature, which is a physiological process. The lab of Britta Qualmann also found that syndapin I plays a crucial role in directing the large GTPase dynamin to membranes.