A number of early studies were directed towards harnessing its antibiotic activity. For example, it was tested as both a nose and throat spray for treating the common cold and as an ointment for treating fungal skin infections However, during the 1950s and 1960s, it became apparent that, in addition to its antibacterial, antiviral, and antiprotozoal activity, patulin was toxic to both plants and animals, precluding its clinical use as an antibiotic.
A number of pioneering studies sought to capitalize on its antimicrobial potential. For example, it was explored as both a nasal and throat spray for treating the common cold and as an ointment for treating fungal skin infections However, during the 1950s and 1960s, it became evident that, in addition to its antibacterial, antiviral, and antiprotozoal properties, patulin was toxic to both plants and animals, precluding its use as a clinical antibiotic.