Here, sensitization to Rh D antigens (usually by feto-maternal transfusion during pregnancy) may lead to the production of maternal IgG anti-D antibodies which can pass through the placenta. This is of particular importance to D negative females at or below childbearing age, because any subsequent pregnancy may be affected by the Rh D hemolytic disease of the newborn if the baby is D positive.
Here, sensitization to Rh D antigens (typically through maternal-fetal blood exchange during pregnancy) may result in the production of maternal IgG anti-D antibodies that can cross the placenta. This is particularly crucial for D negative females under or below childbearing age, as any subsequent pregnancy may be impacted by the Rh D hemolytic disease of the newborn if the baby is D positive.