Its southern terminus is at the Kentucky state line on the Carl Perkins Memorial Bridge over the Ohio River near Portsmouth, and its northern terminus is at an interchange with the State Route 73/State Route 104 concurrency, just north of a complex interchange with U.S. Route 52 about  west of Portsmouth.
The highway's southernmost point is situated on the Kentucky state line over the Ohio River in Portsmouth, near the Carl Perkins Memorial Bridge, whereas its northern endpoint is located at an intersection with State Route 73 and State Route 104 convergence, close to a major interchange with U.S. Route 52 west of Portsmouth.