As a post-translational modification, MYCN binding to C-terminal domains of tetrameric p53 impacts p53 promoter selectivity and interferes other cofactors binding to this region.
MYCN's post-translational modification affects the p53 protein by binding to its C-terminal domain within a tetrameric structure. This interaction alters p53's ability to regulate gene expression, specifically impacting promoter selectivity and hindering other cofactors from binding to this region.