De Leon was the second child of Jose Seoane de Leon (1918–2008) of Spanish Filipino descent, and Emma Manahan Ramos (1925–2019). His paternal grandfather was the first mayor of Malolos, Bulacan.
De Leon's family background includes his father, a man of Spanish Filipino heritage, and his mother, Emma Manahan Ramos. His paternal grandfather held the position of the first mayor of Malolos, Bulacan.