On 11 July 2015, Darmian signed for English club Manchester United for an undisclosed fee, believed to be £12.7 million. He signed a four-year contract with an option to extend it for a further year. He made his debut for the club against Club América during preseason on 17 July, playing the first 45 minutes, with United winning 1–0.
On July 11, 2015, Darmian transferred to Manchester United, an English club, for an undisclosed fee believed to be £12.7 million. He signed a four-year contract with the option to extend it by one year. On July 17 during preseason, he made his debut against Club América, playing the first 45 minutes, and United won 1–0.