Canistro, located in the Roveto valley, borders to the north with Capistrello and the frazione of Pescocanale, to the east with the municipality of Luco dei Marsi, to the south with Civitella Roveto and to the west with the mountainous territory of Filettino, in Lazio, from which it is separated from the Simbruini mountains.
Canistro is situated within the Roveto valley, bordering Capistrello, Pescocanale, Luco dei Marsi, Civitella Roveto, and Filettino in Lazio, with the Simbruini mountains separating it from these regions.