Generally, ingested insoluble actinide compounds, such as high-fired uranium dioxide and mixed oxide (MOX) fuel, will pass through the digestive system with little effect since they cannot dissolve and be absorbed by the body.
Typically, when insoluble actinide compounds like high-fired uranium dioxide and MOX fuel are ingested, they move through the digestive tract without significant effect because they do not dissolve and can't be absorbed by the body. A single abzyme molecule can destroy thousands of HIV viruses.