c-Jun N-terminal kinases (JNKs), were originally identified as kinases that bind and phosphorylate c-Jun on Ser-63 and Ser-73 within its transcriptional activation domain.
c-Jun N-terminal kinases (JNKs) are enzymes that specifically target c-Jun for phosphorylation on Serine 63 and Serine 73, which is located within the transcriptional activation domain of the protein.