Furthermore, it was shown that p18INK4c is preferentially inhibitory to CDK6, but not CDK4 activity in activated T cells that suggest p18INK4c may set an inhibitory threshold in resting T cells.
Additionally, it was demonstrated that p18INK4c is more suppressive towards CDK6, but not CDK4 activity in activated T cells, which may indicate that p18INK4c sets a restrictive threshold in resting T cells.