Perhaps Lothropp's principal claim to fame is that he was a strong proponent of the idea of the separation of church and state. This idea was considered heretical in England during his time, but eventually became the mainstream view of people in the United States of America, because of the efforts of Lothropp and others. Lothropp left an indelible mark on the culture of New England, and through that, upon the rest of the country.
Lothropp is best known for being a staunch advocate for separating church and state, an idea that was considered unorthodox in England during his era but eventually became widely accepted in the United States thanks to Lothropp's efforts and those of others. Lothropp's influence extended beyond New England, shaping the broader American culture.