This imprint control region is normally bound by an insulator on the maternal allele, which represses an enhancer from acting on the Igf2 gene. This insulator is absent on the paternal allele and allows it access to the gene.
This boundary control region is typically confined by an insulator on the maternal allele, which prevents an enhancer from influencing the Igf2 gene. In contrast, the paternal allele lacks this insulator, enabling it to interact with the gene.