In 1485 he was Gonfaloniere di Giustizia, and after that he served as Podestà of Colle di Val d'Elsa. He was among the civis et architectus working on the facade of S. Maria del Fiore in January 1491. His presence in the executive branch of the Florentinian government suggests that Manetti was well connected with influential thinkers of his time.
Manetti held key roles, including Gonfaloniere di Giustizia and Podestà of Colle di Val d'Elsa, from 1485 onwards. He contributed to the design of S. Maria del Fiore's facade in January 1491 as part of a civic team. His presence within the Florentine government indicates his relationships with influential minds.