After entering Guadalajara, Fed-15 suddenly turns southward along the city's southwestern edge and travels through small communities along the southern shore of Lake Chapala (intersecting Fed-13) before crossing into the state of Michoacán. In this part of Fed-15's trajectory, the highway is known as the "Morelia-Guadalajara Highway" (Carretera Morelia-Guadalajara).
After entering Guadalajara, Fed-15 changes course southward along the city's southwestern edge and travels through communities along the southern shore of Lake Chapala before crossing into Michoacán. This section is known as the "Morelia-Guadalajara Highway" (Carretera Morelia-Guadalajara).