CB signaling naturally modulates synaptic transmission and mediates psychoactivity, and synthetic cannabinoids mimic these same actions. Although the efficacy of Levonantradol is dependent on the level of GCPR activity, Full agonists like Levonantradol have the ability to activate GPCRs and convert Gα into a high affinity state for GTP or low affinity state for GDP.
CB signaling controls synaptic transmission and psychoactivity, with synthetic cannabinoids replicating these effects. The efficacy of Levonantradol is contingent on GCPR activity; full agonists such as Levonantradol can activate GPCRs and change the affinity of Gα to either high or low states for GTP or GDP.