The single peaked at number three on the US Billboard Hot 100 and number four on the Billboard Hot R&B Singles and Adult Contemporary charts. "Breathe Again" became one of Braxton's most successful international hits, reaching number two in Australia, New Zealand and the United Kingdom and peaking within the top 10 in several European countries and Canada.
"Breathe Again" achieved significant chart success, reaching number three on the US Billboard Hot 100 and number four on the Billboard Hot R&B Singles and Adult Contemporary charts. It became one of Braxton's most successful international hits, topping the charts in Australia, New Zealand, and the United Kingdom, while also achieving top 10 positions in several European countries and Canada.