As this translocation is passed to the next generation, it can become unbalanced. Individuals with Emanuel syndrome inherit an unbalanced translocation between chromosomes 11 and 22 in the form of a der(22) chromosome. (This der(22) chromosome is classified as one of the small supernumerary marker chromosomes.)
When this genetic abnormality is passed down to the next generation, it can become unstable. Individuals with Emanuel syndrome inherit an unbalanced translocation between chromosomes 11 and 22, manifesting as a der(22) chromosome, which is considered one of the smaller supernumerary marker chromosomes.