The Somatomedin B domain interacts with the urokinase receptor, and this interaction has been implicated in cell migration and signal transduction. High plasma levels of both PAI-1 and the urokinase receptor have been shown to correlate with a negative prognosis for cancer patients. Cell adhesion and migration are directly involved in cancer metastasis, which provides a probable mechanistic explanation for this observation.
The Somatomedin B domain engages with the urokinase receptor, which has been connected to cell migration and signal transduction. High plasma concentrations of both PAI-1 and the urokinase receptor have been linked to unfavorable outcomes in cancer patients. Cell adhesion and migration are crucial for cancer metastasis, suggesting a potential mechanism for these observations.