While there is currently little evidence to support this (and mounting evidence to refute it), some early studies implicated the Ephs to play a part in the signaling of limb development. In chicks, EphA4 is expressed in the developing wing and leg buds, as well as in the feather and scale primordia.
Although there is currently limited proof to support this idea (and increasing evidence to contradict it), some initial studies suggested that the Ephs might be involved in the regulation of limb development. In chicks, EphA4 is expressed in the developing wing and leg buds, as well as in the feather and scale primordia.