US 50's bypass of Berlin was completed in 1958. Salisbury Parkway (now US 50 Business) from MD 349 to Main Street was completed by 1964 and US 50's four-lane divided highway between MD 346's western terminus and the US 50–MD 346 intersection west of Berlin opened in 1965. MD 346 was assigned to the old alignment of US 50 from Salisbury to west of Berlin in 1966 and through Berlin in 1967.
US 50's circumvention of Berlin was finished in 1958. Salisbury Parkway (now US 50 Business) from MD 349 to Main Street was completed by 1964 and the four-lane divided highway of US 50 between MD 346's western terminus and the US 50–MD 346 intersection west of Berlin opened in 1965. MD 346 was assigned to the old route of US 50 from Salisbury to west of Berlin in 1966 and through Berlin in 1967.