Upon binding to the LTβ receptor, LT-αβ transmits signals leading to proliferation, homeostasis and activation of tissue cells in secondary lymphoid organs through induced expression of chemokines, major histocompatibility complex, and adhesion molecules. LT-αβ, which is produced by activated TH1, CD8+ T cells, and natural killer (NK) cells, is known to have a major role in the normal development of Peyer's patches.
Upon binding to the LTβ receptor, LT-αβ initiates signals that lead to cell proliferation, homeostasis, and activation in secondary lymphoid organs by inducing the expression of chemokines, major histocompatibility complex, and adhesion molecules. This molecule, produced by activated T helper 1 (TH1), CD8+ T cells, and natural killer (NK) cells, is essential for the development of Peyer's patches.