Aspirin and Curcumin (diferuloylmethane) too activate caspase-8 to cleave and translocate Bid, induced a conformational change in and translocation of Bax and cytochrome-c release.
Caspase-8 is activated by Aspirin and Curcumin (diferuloylmethane), leading to the cleavage and movement of Bid. This results in a structural change in and movement of Bax, culminating in cytochrome-c release.