MD 300 crosses Andover Branch and curves to the northeast at Busic Church Road to its eastern terminus at the Delaware state line, where Sudlersville Road continues east as DE 300 toward the town of Smyrna.
The highway MD 300 intersects with Andover Branch and turns northeast at Busic Church Road, ending at the Delaware border, where Sudlersville Road resumes eastward as DE 300 toward Smyrna.