MD 276 begins at an intersection with MD 222 (Main Street) opposite Ferry Street in the town of Port Deposit two blocks east of the Susquehanna River. The two-lane undivided state highway, which is Center Street in town and becomes Jacob Tome Memorial Highway at the town limit, which the route follows northeast as it ascends the high bluff above the river. MD 276 follows the town limit along the northwestern edge of the property of former United States Naval Training Center Bainbridge, until shortly before its intersection with the northern terminus of MD 275 (Perrylawn Drive).
MD 276 is a two-lane state highway that starts at an intersection in Port Deposit and follows a route northeast up a bluff above the Susquehanna River. It passes through the former Naval Training Center Bainbridge before reaching its northern terminus at MD 275 (Perrylawn Drive).