The administration of folinic acid, which forces the methylation of CXCL 16, induces high levels of methylation of the CXCL 16 gene promoter in colon, ileum and lung and causes iNKT cells accumulation in these tissues.
The application of folinic acid results in the methylation of CXCL 16, leading to increased methylation of the CXCL 16 gene promoter in colon, ileum, and lung tissues, which subsequently causes a rise in iNKT cells within these areas.