In 1848 he returned to Naples and was instrumental in the events leading King Ferdinand II to issue a Constitution. On 15 May 1848 Romano was again arrested and condemned to death, but managed to turn it into exile, moving to Montpellier in France.
Romano resumed his residence in Naples in 1848 and contributed significantly to the circumstances that prompted King Ferdinand II to adopt a Constitution. On 15 May 1848 Romano was apprehended again and received a death sentence, but he was able to transform it into exile, ultimately settling in Montpellier, France.