In the 1930 renumbering of state highways in New York, the segment of current NY 350 between Atlantic Avenue and Ridge Road became part of an extended NY 35, which had ended at a junction west of the village of Avon in Livingston County prior to 1930. The extension took NY 35 northeastward through Monroe and Wayne Counties to a new terminus in the town of Ontario.
During the 1930 reorganization of New York state highways, the section of current NY 350 between Atlantic Avenue and Ridge Road was merged with an extended NY 35, which had previously concluded at a junction west of Avon village in Livingston County before 1930. The extension then proceeded northeastward through Monroe and Wayne Counties to establish a new endpoint in the town of Ontario.