San Francisco de Sales is bounded on the north by the municipality of Supatá, the west by La Vega, on the south by Facatativá, to the southeast by El Rosal, and on the east by Subachoque.
In terms of its geographical boundaries, San Francisco de Sales is positioned with Supatá to the north, La Vega to the west, Facatativá to the south, El Rosal to the southeast, and Subachoque to the east.