For instance, the use of TRPV1 agonists would potentially inhibit nociception at TRPV1, particularly in pancreatic tissue where TRPV1 is highly expressed. The TRPV1 agonist capsaicin, found in chili peppers, has been indicated to relieve neuropathic pain. TRPV1 antagonists inhibit nociception at TRPV1.
For example, the application of TRPV1 activators could potentially block nociception at TRPV1, particularly in pancreatic tissue where TRPV1 is highly expressed. Capsaicin, a TRPV1 activator found in chili peppers, has been shown to relieve neuropathic pain. TRPV1 antagonists inhibit nociception at TRPV1.