Tetrahydrofolate gets this extra carbon atom by sequestering formaldehyde produced in other processes. These single-carbon moieties are important in the formation of precursors for DNA synthesis. A shortage in tetrahydrofolic acid (FH4) can cause megaloblastic anemia.
Tetrahydrofolate acquires the extra carbon atom from formaldehyde generated during other metabolic processes. These single-carbon moieties are necessary for DNA precursor formation. A shortage of tetrahydrofolic acid (FH4) might result in megaloblastic anemia.