Humberstone did not specialize; he worked on comedies, dramas, and melodramas. Humberstone is best known today for the seminal film noir I Wake Up Screaming (1941) and his work on some of the Charlie Chan films.
Humberstone's career encompassed various genres, including comedies, dramas, and melodramas. His most notable contribution is his role in creating the iconic film noir "I Wake Up Screaming" (1941), as well as his work on several Charlie Chan films.