In the 2021 Census of Population conducted by Statistics Canada, Pikwitonei had a population of 55 living in 20 of its 37 total private dwellings, a change of  from its 2016 population of 64.
According to the 2021 Census of Population conducted by Statistics Canada, the population of Pikwitonei was 55 people residing in 20 out of its 37 total private dwellings. This represents a decrease from its 2016 population of 64.