After the loss of TH+ (tyrosine hydroxylase-positive) substantia nigra compacta (SNc) neurons due to Parkinson’s-induced neurodegeneration, the number of these neurons can partially recover via a cell phenotype "shift" from TH- (tyrosine hydroxylase-negative) to TH+.
After the loss of TH+ substantia nigra compacta (SNc) neurons due to Parkinson's-induced neurodegeneration, the number of these neurons can partially recover via a shift in their cellular phenotype from TH- (tyrosine hydroxylase-negative) to TH+.