Similar to other nuclear receptors, when activated, FXR translocates to the cell nucleus, forms a dimer (in this case a heterodimer with RXR) and binds to hormone response elements on DNA, which up- or down-regulates the expression of certain genes.
Like other nuclear receptors, when activated, FXR moves to the cell nucleus, forming a complex with RXR, and binding to specific DNA sequences called hormone response elements. This interaction can either increase or decrease the activity of certain genes.