Near Yuba, SH-78 curves west to head toward Achille, where it meets State Highway 91. It curves back north here, meets State Highway 70E, and then passes through the east part of Durant, where it crosses US-70.
In the vicinity of Yuba, SH-78 makes a western turn toward Achille, where it intersects with State Highway 91. The highway then resumes its northern course, meeting State Highway 70E, and passes through the eastern part of Durant before crossing US-70.