East of the Highlandtown neighborhood, MD 150 turns east onto Lombard Street, which crosses over three rail spurs that head south to Canton; one line splits from CSX's Philadelphia Subdivision railroad line, while the other two spring from the Amtrak's Northeast Corridor railroad line and are operated by Norfolk Southern Railway. The state highway's run on Lombard Street ends at Ponca Street; Lombard Street continues east toward ramps to northbound I-895 (Harbor Tunnel Thruway) and Johns Hopkins Bayview Medical Center.
To the east of Highlandtown, MD 150 turns onto Lombard Street, which crosses over three rail lines that head south to Canton; one line branches off from CSX's Philadelphia Subdivision railroad, while the other two originate from Amtrak's Northeast Corridor and are managed by Norfolk Southern. The highway on Lombard Street concludes at Ponca Street; Lombard Street then proceeds east toward ramps for northbound I-895 (Harbor Tunnel Thruway) and Johns Hopkins Bayview Medical Center.