In 1953, Paul Fatt and Bernard Katz discovered voltage gated calcium channels in crustacean muscle. The channels exhibited different activation voltages and calcium conducting properties and were thus separated into High Voltage Activating channels (HVA) and Low Voltage Activating channels (LVA). After further experimentation, it was found that HVA channels would open to 1,4-dihydropyridine (DHPs).
In 1953, Paul Fatt and Bernard Katz found voltage-gated calcium channels in crustacean muscle. These channels had different activation voltages and calcium-conducting properties, leading to the classification of HVA and LVA channels. Later studies demonstrated that HVA channels would open to 1,4-dihydropyridine (DHPs).