The 2006 State of Origin series was the 25th year that the annual best-of-three series of interstate rugby league football matches between the Queensland and New South Wales representative teams was contested entirely under 'state of origin' selection rules.
In 2006, the State of Origin series marked the 25th occasion when the annual best-of-three match series between Queensland and New South Wales representatives was played according to 'state of origin' selection criteria.