Matuzumab binds to epidermal growth factor receptor (EGFR) on the outer membrane of normal and tumor cells. The matuzumab epitope has been mapped to domain III of the extracellular domain of the EGFR. The EGFR is receptor tyrosine kinase which binds multiple growth factors including EGF (epidermal growth factor) and other members of the EGF family of growth factors, resulting in activation of its tyrosine kinase activity.
Matuzumab interacts with the epidermal growth factor receptor (EGFR) on normal and tumor cells. The matuzumab epitope is found in domain III of the EGFR's extracellular region. The EGFR functions as a tyrosine kinase receptor that binds various growth factors, including EGF and other members of the EGF family, resulting in activation of its tyrosine kinase activity.