further demonstrated in mouse cells that endogenous RNAa mediated by miRNAs functions in a physiological context and is possibly exploited by cancer cells to gain a growth advantage. Since then, a number of miRNAs have been shown to upregulate gene expression by targeting gene promoters  or enhancers, thereby, exerting important biological roles. A good example is miR-551b-3p which is overexpressed in ovarian cancer due to amplification.
Evidence from mouse cells has shown that endogenous RNA interference mediated by microRNAs functions within a physiological framework and may be utilized by cancer cells to gain a competitive edge. Subsequent studies have revealed that numerous microRNAs can enhance gene expression by targeting regulatory elements, thereby, contributing to vital biological processes. For instance, miR-551b-3p is overexpressed in ovarian cancer due to amplification.