Chronic daily administration of migraine prophylactic drugs (topiramate, valproate, propranolol, amitriptyline, and methysergide) dose-dependently suppressed frequency of CSD induced by continuous cortical application of 1 M KCl solution. However lamotrigine (a drug with specific anti-aura action, but no efficacy in migraine in general) has a marked suppressive effect which correlates with its rather selective action on the migraine aura.
Daily treatment with medications intended to prevent migraines (topiramate, valproate, propranolol, amitriptyline, and methysergide) had a dose-dependent impact in reducing the frequency of cluster headaches triggered by applying a high concentration of potassium chloride solution to the cortex. In contrast, lamotrigine, which is specifically effective against migraine auras but lacks efficacy in general migraines, showed a significant suppressive effect that aligns with its targeted action on migraine auras.