Given this model, it is clear that the DEE algorithm is guaranteed to find the optimal solution; that is, it is a global optimization process. The single-rotamer search scales quadratically in time with total number of rotamers.
Considering this framework, it is apparent that the DEE algorithm guarantees discovering the ideal outcome; thus, it functions as a global optimization method. The single-rotamer search exhibits an exponential growth in computational time relative to the total quantity of rotamers.