The effect of these changes on drug protein binding and drug delivery, however, appear to be minimal. AGP shows a complex interaction with thyroid homeostasis: AGP in low concentrations was observed to stimulate the thyrotropin (TSH) receptor and intracellular accumulation of cyclic AMP. High AGP concentrations, however, inhibited TSH signalling.
The effects of these modifications on drug protein binding and drug delivery appear to be minimal.  AGP exhibits a complex relationship with thyroid homeostasis: low concentrations stimulate the TSH receptor and increase cyclic AMP levels. However, high concentrations inhibit TSH signaling.