Following the formation of anti-K, subsequent blood transfusions may be marked by destruction of the new cells by these antibodies, a process known as hemolysis. Anti-K does not bind complement, therefore hemolysis is extravascular. Individuals without K antigens(K0) who have formed an antibody to a K antigen, must be transfused with blood from donors who are also K0 to prevent hemolysis.
Following the development of anti-K antibodies, subsequent blood transfusions can result in the destruction of new cells by these antibodies, known as hemolysis. Since Anti-K does not interact with complement, hemolysis occurs outside the circulatory system (extravascular). Individuals lacking K antigens (K0) who have formed an antibody against a K antigen must receive blood from donors who are also K0 to prevent hemolysis.