Sugars have an overwhelming effect on gene expression. In yeast, glucose levels are managed by controlling the mRNA levels of hexose  transporters, while in mammals, the response to glucose is more tightly controlled with glucose metabolism and is therefore much more complex.
The influence of sugars on gene expression is significant, but the way it's managed differs between yeast and mammals. Yeast relies on mRNA regulation for glucose control, while mammals utilize glucose metabolism as a more complex mechanism.