A descendant of Marranos from around the city of Celorico, in the province of Beira, Portugal, he studied medicine at the University of Salamanca together with his older brother Fernando Isaac, and while the latter was given to his studies, Michael spent his time in singing serenades under ladies' balconies. After having completed his education, he left Spain for Venice.
A descendant of Marranos from around the city of Celorico, in the province of Beira, Portugal, he studied medicine at the University of Salamanca alongside his older brother Fernando Isaac. While the latter was engrossed in his studies, Michael devoted himself to serenading ladies on balconies. After completing his education, he departed from Spain for Venice.