Pseudoproline dipeptides have proven particularly effective in the synthesis of intractable peptides, long peptides/small proteins, and cyclic peptides, enabling in many cases the production of peptides that otherwise could not be made. These dipeptides are extremely easy to use: simply substitute a serine or threonine residue together with the preceding amino acid residue in the peptide sequence with the appropriate pseudoproline dipeptide (see the figure on your right).
Pseudoproline dipeptides have demonstrated remarkable efficacy in creating intricate peptides, long peptides/small proteins, and cyclic peptides. They are remarkably simple to utilize: replace a serine or threonine residue with its preceding amino acid in the peptide sequence with the suitable pseudoproline dipeptide (refer to the figure on your right).