Tumour suppressor genes have also been highlighted as being silenced or degraded in nodular hyperplastic parathyroid tissue. One such gene, p53, has been shown to regulate multiple tumour suppressor pathways and in tumorigenesis can be degraded by b-catenin. This pathway, in some aspect, is mediated by CACYBP, which is highly expressed in nodular parathyroid hyperplasia.
Tumor suppressor genes are found to be silenced or degraded in nodular hyperplastic parathyroid tissue. One such gene, p53, regulates multiple tumor suppressor pathways and can be degraded by b-catenin. This pathway is mediated by CACYBP, which is highly expressed in nodular parathyroid hyperplasia.