Spidey's game play is almost identical to that of its predecessor, whereby he has to go around and save any civilians that are in trouble, engage in combat with thugs and (in the Nintendo DS version) take part in 3 touch screen mini-games: The stroke game, the web draw and the arm/disarm games.
Spidey's gameplay is very similar to that of his previous game, with the player rescuing civilians, fighting enemies, and playing touch screen mini-games.