Over the next several years, many changes to the route were spurred by the creation of the United States Highway system. In 1927, US 90 was newly designated in Texas over a route that replaced the portion of SH 54 between Alpine and the combined route of the new US 80 and SH 1 in Van Horn. On January 18, 1928, SH 130, a predecessor of US 62 and US 180 was designated from the present northern terminus of SH 54 west to El Paso.
In subsequent years, alterations to the route were influenced by the creation of the United States Highway system. In 1927, US 90 was newly established in Texas over a path that replaced the segment of SH 54 between Alpine and the junction of the new US 80 and SH 1 in Van Horn. On January 18, 1928, SH 130, which later became part of US 62 and US 180, was designated from the current northern endpoint of SH 54 west to El Paso.