The continued storage of GAGs leads to abnormalities in multiple organ systems. After 18 months, children with severe MPS II may experience developmental decline and progressive loss of skills. The thickening of the heart valves and walls of the heart can result in progressive decline in cardiac function.
The prolonged storage of GAGs has far-reaching consequences for various organ systems. In children with severe MPS II, after 18 months, there is a noticeable decline in developmental abilities and skills, highlighting the importance of addressing this condition promptly. The thickening of heart valves and walls can lead to a gradual decrease in cardiac efficiency.