Sironko is approximately  by road, northeast of the city of Mbale on the highway between Mbale and Moroto. This is approximately , by road, northeast of Kampala, Uganda's capital and largest city.
Sironko is roughly central by road, northeast of Mbale town on the route connecting it to Moroto. It is located around , by road, northeast of Kampala, the capital city and largest settlement in Uganda.