Through Vasari's example, Tosini adopted a vocabulary derived from the work of Michelangelo and painted some of his best-known works in this manner (e.g. Night, c. 1560; Rome, Galleria Colonna, and Leda, c. 1560; Rome, Galleria Borghese). He executed several important commissions late in his career: the fresco decoration of three city gates of Florence (1560s), the altar in the chapel at the Villa Caserotta (1561), near San Casciano Val di Pesa, and the paintings on the sides and back of the tabernacle of the high altar of Santa Maria della Quercia (1570), Viterbo.
Through Vasari's illustration, Tosini adopted a vocabulary inspired by Michelangelo and created some of his most renowned works in this style (e.g. Night, circa 1560; Rome, Galleria Colonna, and Leda, circa 1560; Rome, Galleria Borghese). He executed several significant commissions towards the end of his career: the fresco decoration of three city gates of Florence (1560s), the altar in the chapel at the Villa Caserotta (1561), near San Casciano Val di Pesa, and the paintings on the sides and back of the tabernacle of the high altar of Santa Maria della Quercia (1570), Viterbo.