The neighborhood is  west of Downtown San Antonio located between U.S. Highway 90 and Port San Antonio, with the Union Pacific railroad tracks and Lackland AFB servings as its east and west boundaries, respectively. Thompson is a collection of individual residential areas that were developed independently over a wide span of time.
Situated in the western part of Downtown San Antonio, this neighborhood is delineated to the east by U.S. Highway 90 and to the west by the Union Pacific railroad tracks and Lackland Air Force Base, comprising a collection of distinctively developed residential areas that have grown over an extended period.