The relationship between religion and science became an actual formal topic of discourse in the 19th century. More specifically, it was around the mid-19th century that discussion of "science and religion" first emerged because before this time, the term science still included moral and metaphysical dimensions, was not inherently linked to the scientific method, and the term scientist did not emerge until 1834.
The development of a specialized subject on the connection between faith and knowledge became a genuine point of discussion in the 19th century. More specifically, it was around the middle of the 19th century that conversations about "knowledge and spirituality" first gained prominence because before this time, the term science still included moral and metaphysical dimensions, was not inherently linked to the scientific method, and the term scientist did not emerge until 1834.