When used in conjunction with in vitro fertilization (IVF), controlled ovarian hyperstimulation confers a need to avoid spontaneous ovulation, since oocyte retrieval of the mature egg from the fallopian tube or uterus is much harder than from the ovarian follicle.
Controlled ovarian hyperstimulation used in conjunction with IVF presents challenges related to preventing spontaneous ovulation, as extracting a mature egg from the fallopian tube or uterus is more complicated than from the ovarian follicle.