Most cells in the human body have two receptors for TNF-alpha: TNFR1 and TNFR2. The binding of TNF-alpha to TNFR1 has been shown to initiate the pathway that leads to caspase activation via the intermediate membrane proteins TNF receptor-associated death domain (TRADD) and Fas-associated death domain protein (FADD).
Most human cells have two receptors for TNF-alpha: TNFR1 and TNFR2. Binding of TNF-alpha to TNFR1 triggers a pathway that activates caspases through the involvement of TRADD and FADD, which are membrane proteins.