Sirens syndicated run featured a slightly different cast, with Adrienne-Joi Johnson and Liza Snyder reprising their lead roles, and Jayne Heitmeyer replacing Jayne Brook, but was still set in Pittsburgh.
In the syndicated version of "Sirens," Adrienne-Joi Johnson and Liza Snyder continued their roles as leads, while Jayne Heitmeyer replaced Jayne Brook. The show's setting remained in Pittsburgh.