Leucine in particular has been shown to serve an important role in the metabolic pathway for insulin via activation of the rapamycin complex 1 (mTORC1) and protein S6 kinase 1 (S6K1) for which over-activation leads to insulin resistance. Further studies illustrate that ketogenic amino acid rich diets may aid in decreasing obesity and insulin resistance, but their usage remains disputed.
Leucine contributes significantly to the metabolic pathway for insulin by activating mTORC1 and S6K1, which can result in insulin resistance when over-activated. Research also indicates that diets rich in ketogenic amino acids may help manage obesity and insulin resistance, though their effectiveness is still uncertain.