MD 26 connects Frederick and Baltimore with the highway's namesake of Libertytown in eastern Frederick County, the suburban area of Eldersburg in southern Carroll County, and the western Baltimore County suburbs of Randallstown, Milford Mill, and Lochearn.
MD 26 links the cities of Frederick and Baltimore to Libertytown, a suburban area in eastern Frederick County, as well as the suburbs of Eldersburg in southern Carroll County and Randallstown, Milford Mill, and Lochearn in western Baltimore County.