Sphingolipid metabolites, such as ceramide, sphingosine and sphingosine-1-phosphate, are lipid second messengers involved in diverse cellular processes. There are two forms of SphK, SphK1 and SphK2.
Sphingolipids, particularly ceramide, sphingosine, and sphingosine-1-phosphate, act as crucial signaling molecules within cells. SphK1 and SphK2 are the two primary enzymes responsible for regulating the synthesis of these lipids.