HBII-99 is predicted to guide the 2'O-ribose methylation of 28S rRNA G3878. U106 contains conserved antisense elements which would predict U106 methylates residues G1536 and U1602 of 18S rRNA.
HBII-99 is expected to regulate the methylation of 28S rRNA at position G3878, utilizing a mechanism similar to that employed by U106, which also contains conserved antisense elements. This would suggest that U106 will methylate residues G1536 and U1602 in 18S rRNA.