Medoff's screen credits include adaptations of his plays Red Ryder and Children of a Lesser God, for which he was nominated for an Oscar, BAFTA, and Writers Guild of America Award, Clara's Heart (for which he cast, and subsequently "discovered", Neil Patrick Harris), and City of Joy.
Medoff's film career includes notable adaptations of his stage plays Red Ryder and Children of a Lesser God, earning him prestigious awards, in addition to casting and discovering talent like Neil Patrick Harris in Clara's Heart, and producing the movie City of Joy.