Chambers was elected as an Anti-Masonic candidate to the Twenty-third and Twenty-fourth Congresses. After his time in Congress, he resumed the practice of law and was a member of the State constitutional convention in 1837. He was appointed a justice of the Pennsylvania Supreme Court on April 12, 1851, which position he held until it was vacated by constitutional provision.
Chambers ran as an Anti-Masonic candidate for the Twenty-third and Twenty-fourth Congresses. After his congressional term, he resumed legal practice and participated in the State constitutional convention of 1837. He was appointed a justice of the Pennsylvania Supreme Court on April 12, 1851, holding this position until it was vacated by constitutional provision.