Moreover, as a consequence of immunodominance, an individual's CTL response is limited to a few epitopes of a specific HLA allele although six HLA class 1 alleles are expressed.
Immunodominance restricts the immune system's ability to respond effectively to all epitopes on a particular HLA allele due to its dominance in the response. This is because only a few epitopes are recognized and targeted by CTLs, despite the presence of multiple HLA class 1 alleles.