A lack of c-met disrupts secondary myogenesis and—as in LBX1—prevents the formation of limb musculature. This local action of FGFs (Fibroblast Growth Factors) with their RTK receptors is classified as paracrine signalling. As RTK receptors phosphorylate multiple tyrosine residues, they can activate multiple signal transduction pathways.
A deficiency of c-met impairs secondary myogenesis and, similar to LBX1, prevents limb musculature formation. This localized effect of FGFs (Fibroblast Growth Factors) through their RTK receptors is categorized as paracrine signaling. The activation of multiple tyrosine residues by RTK receptors triggers the activation of numerous signal transduction pathways.