At the same time, the G-protein subunit Gα directly activates an enzyme called protein tyrosine kinase (PTK), which phosphorylates serine and threonine residues in the tail of the chemokine receptor, causing its desensitisation or inactivation. The initiated MAP kinase pathway activates specific cellular mechanisms involved in chemotaxis, degranulation, release of superoxide anions, and changes in the avidity of cell adhesion molecules called integrins.
Simultaneously, the G-protein subunit Gα directly activates an enzyme called protein tyrosine kinase (PTK), which phosphorylates serine and threonine residues on the chemokine receptor's tail, leading to its desensitization or inactivation. The activated MAP kinase pathway then triggers cellular processes like chemotaxis, degranulation, superoxide anion release, and changes in cell adhesion molecule avidity (integrins).