Renin is secreted by renal juxtaglomerular cells and catalyses the conversion of angiotensinogen into angiotensin I which is the rate-limiting step in the production of angiotensin II. Angiotensin II induces hypertension and REN therefore requires tight expression control.
Renin is released by renal juxtaglomerular cells and catalyzes the conversion of angiotensinogen into angiotensin I, which is the rate-limiting step in the production of angiotensin II. Angiotensin II causes high blood pressure and REN therefore needs strict expression regulation.