Interactions of Lorcainide with Nav1.5 are time and voltage dependent. Class 1c drugs have a characteristically slow dissociation rate, which will slow the upstroke duration and amplitude of ventricular myocytes’ action potential and prolong the PR, QRS and QT intervals of an ECG. Lorcainide also increases the ventricular fibrillation threshold in a dose-dependent fashion.
Lorcainide's interactions with Nav1.5 are time and voltage dependent, leading to slowed dissociation rates, prolonged action potential durations, and increased PR, QRS, and QT intervals on an ECG. Lorcainide also increases the fibrillation threshold in a dose-dependent manner.