PA 16 runs east past more farms and woods and passes through Zullinger, where it bends east-southeast and heads past residences and a few businesses. The road passes near farm fields before it enters the borough of Waynesboro and becomes West Main Street, where it is lined with homes. The route heads into the downtown area and comes to a junction with PA 316, where that route joins PA 16 for a block before turning to the south.
PA 16 travels eastward through farmland and wooded areas, passing by farms and residences in Zullinger before entering Waynesboro as West Main Street. It then reaches a junction with PA 316, where they briefly merge before PA 316 turns south.