MD 481 begins at an intersection with MD 309 (Starr Road) north of Queen Anne. The two-lane undivided state highway heads north through farmland, passing Crouse Mill Road, which is used to access Tuckahoe State Park from the west.
MD 481 begins where MD 309 (Starr Road) meets near Queen Anne. The highway then traverses agricultural regions, crossing Crouse Mill Road, which offers access to Tuckahoe State Park via the west.