SH-53 begins at a T intersection in Walters, where State Highway 5 makes up the western and southern legs of the T. SH-53 runs eastward from here, crossing East Cache Creek. At Fivemile Corner, the road intersects SH-65, five miles (8 km) east of Walters.
SH-53 commences at a T intersection in Walters, where State Highway 5 forms the western and southern sides of the T. SH-53 proceeds eastward from here, crossing East Cache Creek. At Fivemile Corner, the road intersects with SH-65, five miles (8 km) east of Walters.