The lateral plate mesodermal cells secrete fibroblast growth factors (FGF7 and FGF10) to induce the overlying ectoderm to form an organizer at the end of the limb bud, called the apical ectodermal ridge (AER), which guides further development and controls cell death.
The lateral plate mesodermal cells secrete fibroblast growth factors FGF7 and FGF10 to prompt the overlying ectoderm to develop an organizer at the limb bud's apex, known as the apical ectodermal ridge (AER). This organizer guides further development and controls cell death.