Voltage-gated sodium channels are proteins found throughout the body, however the most influential of these are found in neurons. Because the gate is permanently open and cannot close, there is not an action potential gradient to utilize and signals cannot be received by nerves. This lack of signaling is what causes paralysis of muscles, cardiac failure, and respiratory failure which eventually leads to death.
In the context of voltage-gated sodium channels, it is essential to note that those found in neurons have a significant impact on the body's functioning. The permanent openness of these channels prevents the formation of a signal gradient, which is crucial for nerve communication. This disruption can lead to severe consequences, including paralysis, cardiac failure, and respiratory failure, ultimately resulting in death.