This gene and MAPK8 are also known as c-Jun  N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells.
The gene and MAPK8 are also called c-Jun N-terminal kinases.  This kinase prevents the tagging of tumor suppressor protein p53 for destruction, thus enhancing its stability in normal cells.