Although the overall fold of the human enzyme is similar to that of yeast, the human structure is different in that it has two loops that extend from the general protein structure and into the FAD binding sites when bound the NAD+ molecule, required for catalysis, is not close to the FAD moiety.
Despite the overall shape of the human enzyme being similar to that of yeast, it has a distinctive feature: two loops extend from its main structure and interact with the FAD binding sites when bound to NAD+, an essential cofactor for catalysis, which is not near the FAD moiety.