Situated on the important Vilnius–Hrodna road, the village had a royal estate for accommodation of traveling Grand Dukes and other Lithuanian nobles. After Christianization of Lithuania, the village was one of the first places to construct a Catholic church funded by Vytautas the Great. In 1710, during the Great Northern War, the plague wiped out almost all inhabitants of Perloja.
The village, situated on the crucial Vilnius–Hrodna route, had a royal estate for lodging visiting Grand Dukes and Lithuanian nobles. After Lithuania's Christianization, it was one of the first to build a Catholic church funded by Vytautas the Great. In 1710, during the Great Northern War, the plague nearly eradicated almost all inhabitants of Perloja.