The changes in the ecology of the gingival sulcus impacts gene expression and changes the competitiveness of periodontal pathogens like Porphyromonas gingivalis. Hence, the growth of proteolytic and Gram-Negative Anaerobes (most of the time) will be favoured by fluctuating homeostasis, the natural balance, of the subgingival microflora.
Modifications in the gingival sulcus ecosystem influence gene expression and affect the prevalence of periodontal pathogens like Porphyromonas gingivalis. As a result, proteolytic and Gram-Negative anaerobes (usually) thrive under fluctuating homeostasis within subgingival microflora.