Proteins, such as neurogranin that plays a vital role in postsynaptic function, however, can bind to calmodulin in Ca2+-free or Ca2+-bound state via their IQ calmodulin-binding motifs.
Neurogranin, a protein crucial for postsynaptic function, binds to calmodulin through its IQ calmodulin-binding motif, whether the calcium ion concentration is high or low.