The result is that you can load masses, similar to those used in HPLC, on column per injection, and still maintain a high chromatographic efficiency similar to those attained in GC. Typically, gradient elution is employed in analytical SFC using a polar co-solvent such as methanol, possibly with a weak acid or base at low concentrations ~1%. The apparent plate count per analysis can be observed to exceed 500K plates per meter routinely with 5 um stationary phases.
The outcome is that you can load masses, similar to those used in HPLC, onto columns per injection, while still maintaining high chromatographic efficiency comparable to what's achieved in GC. Typically, gradient elution is utilized in analytical SFC using a polar co-solvent like methanol, possibly with a weak acid or base at low concentrations (around 1%). The apparent plate count per analysis can be observed to exceed 500K plates per meter routinely with 5 µm stationary phases.