Domínguez rematched Gómez in 1999, and again came up short in a decision. In 2001, he was able to land a shot at WBO cruiserweight title holder Johnny Nelson, but lost a decision.
Domínguez competed against Gómez in both 1999 and 2001, failing to secure victories in either match. In 2001, he sought to challenge Johnny Nelson for the WBO cruiserweight title, also losing a decision.