It comes close to the hamlet of Cairo, but bypasses it on a four-lane divided highway that takes it around the northern fringe of the community. As it runs around Cairo, the route connects to NY 145 and briefly overlaps NY 32, the major north–south state route on the west side of the Hudson River.
The road approaches the hamlet of Cairo but takes a detour on a four-lane highway that circumvents the northern part of the community. As it encircles Cairo, the route intersects with NY 145 and briefly shares a path with NY 32, a major north–south state highway on the west side of the Hudson River.