The highway runs  from SR 122, US 221, and US 460 on the south side of Bedford to SR 122 and US 221 on the north side of Bedford. SR 122 Business heads north from its diamond interchange with the Bedford Bypass as Burks Hill Road.
The highway connects to SR 122, US 221, and US 460 on the south side of Bedford and then continues to connect to SR 122 and US 221 on the north side of Bedford.  SR 122 Business branches off from its intersection with the Bedford Bypass as Burks Hill Road.