Prehistorically the banks of San Bruno Creek were settled by the Buriburi tribe of the Ohlone, who have presumably lived in the area since as early as 2000 BC. One Buriburi settlement has been identified along San Bruno Creek, which may have had a population of 15 to 25 people.
The early history of the San Bruno Creek area is marked by the presence of the Buriburi tribe of the Ohlone, who are believed to have lived in the region for thousands of years. A single settlement has been identified along the creek, which may have supported a small community.