The road between Brickerville and Myerstown and Bethel and Pine Grove was an unnumbered, unpaved road. In the 1930s, PA 501 was extended north from US 322 in Brickerville to US 422 and the southern terminus of PA 243 in Myerstown along a paved road.
Before being paved in the 1930s, a dirt road connected Brickerville and Myerstown, and Bethel and Pine Grove. PA 501 was extended north from US 322 in Brickerville to US 422 and the southern terminus of PA 243 in Myerstown along this new paved route.