If the pressure becomes great enough, blood flow to the muscle can be blocked, leading to a condition known as compartment syndrome. Severe damage to the nerve and blood vessels around a muscle can cause the muscle to die and amputation might be necessary.
In extreme cases, excessive pressure can cut off blood flow to the muscle, triggering compartment syndrome. Severe trauma to the nerve and blood vessel networks surrounding the muscle can lead to muscle necrosis, potentially requiring amputation.