He is a scion of the Chernobyl, Chabad, Sanz, and Bobov Hasidic dynasties. He and his twin brother Rabbi Michel Twerski were the youngest sons  of  Rabbi Jacob Israel Twerski (1899–1973) and Rebbetzin Dvorah Leah Twerski (1900–1995).
He is a descendant of the Chernobyl, Chabad, Sanz, and Bobov Hasidic lineages. He and his twin brother Rabbi Michel Twerski were the youngest sons of Rabbi Jacob Israel Twerski (born in 1899 and died in 1973) and Rebbetzin Dvorah Leah Twerski (born in 1900 and died in 1995).