Belatacept, sold under the brand name Nulojix, is a fusion protein composed of the Fc fragment of a human IgG1 immunoglobulin linked to the extracellular domain of CTLA-4, which is a molecule crucial in the regulation of T cell costimulation, selectively blocking the process of T-cell activation.
Belatacept, marketed as Nulojix, is a fusion protein made up of the Fc part of a human IgG1 antibody attached to the extracellular region of CTLA-4. CTLA-4 plays a vital role in regulating T cell stimulation and selectively inhibits T-cell activation.