One final trumpet exit to NY 400 (and by extension, the New York State Thruway) precedes its junction with Harlem Road (NY 240), where county maintenance of NY 16, and thus the overlap with CR 572, ends. Just west of NY 240, NY 16 crosses the Thruway itself as it begins to head to the northwest and enter the city of Buffalo, where the route is locally maintained.
One final exit from NY 400 (and by extension, the New York State Thruway) precedes its junction with Harlem Road (NY 240), where county maintenance of NY 16 ends. Just west of NY 240, NY 16 crosses the Thruway itself as it begins to head to the northwest and enter the city of Buffalo, where the route is locally maintained.