The range forms the Malawi-Mozambique border, and the divide between the watersheds of Mozambique's Revúboé River to the west and Malawi's Shire River to the east. The Lisungwe and Mkulumadzi (Wamkulumadzi) rivers are tributaries of the Shire that originate in the Kirk Range.
The geographical boundary between Malawi and Mozambique is defined by the range, separating the watersheds of the Revúboé River in Mozambique and the Shire River in Malawi. The Lisungwe and Mkulumadzi (Wamkulumadzi) rivers are tributaries of the Shire that originate within the Kirk Range.