In cultivation, Rhododendron spinuliferum grows best in acidic soils of pH 4–6 with a shady aspect and significant organic material in the soil, although excess shade will result in few flowers and leggy habit.
For optimal growth in cultivation, Rhododendron spinuliferum prefers acidic soils with a pH between 4 and 6, a shaded position, and rich organic content. However, too much shade can reduce flowering and cause the plant to grow spindly.