Soon after Anna's father became emperor, in 1195, Isaac Komnenos was dispatched to combat the Uprising of Asen and Peter. He was captured, became a pawn between rival Bulgarian and Vlach factions, and died in chains.
Following Anna's father's ascension to the throne in 1195, Isaac Komnenos was sent to quell the uprising led by Asen and Peter. He was taken prisoner, caught in the conflict between Bulgarian and Vlach factions, and ultimately died while imprisoned.