The AAP recommends "In isoimmune hemolytic disease, administration of intravenousγ-globulin (0.5-1 g/kg over 2 hours) is recommended if the TSB is rising despite intensive phototherapy or the TSB level is within 2 to 3 mg/dL (34-51 μmol/L) of the exchange level . If necessary, this dose can be repeated in 12 hours (evidence quality B: benefits exceed harms).
The AAP advises "In isoimmune hemolytic disease, intravenous γ-globulin (0.5-1 g/kg over 2 hours) should be administered if the TSB is rising despite phototherapy or the TSB level is close to the exchange level between 2 and 3 mg/dL (34-51 μmol/L). If needed, this dose can be repeated every 12 hours (evidence quality B: benefits outweigh harms)."