The standard of care (sometimes also called the "gold standard") for the adjuvant treatment of stage III colon cancer is the FOLFOX chemotherapy protocol (used in Europe, Japan, Canada, and Australia) and respectively the FLOX chemotherapy protocol (used in the USA).
The accepted standard for treating stage III colon cancer with additional therapy is the FOLFOX chemotherapy approach, commonly employed in Europe, Japan, Canada, and Australia, whereas the FLOX regimen is used in the United States.