Hampton began performing in her family's band at a young age. During World War II she formed a quartet with her sisters that eventually became known as the Hamptons Sisters. The women also performed with the Duke Hampton band, their oldest brother's jazz orchestra.
From an early age, Hampton participated in her family's musical group. In 1942, she co-founded a quartet with her sisters, which later gained recognition under the name the Hamptons Sisters. The women also performed alongside the Duke Hampton band, their older brother's jazz ensemble.