Demetrios Pepagomenos is lampooned in a 15th-century satire, Mazaris' Journey to Hades, as a doctor who poisoned himself. Mazaris says he had two sons: the older, Saromates ("Lizard Eyes"), also a doctor, and Theodosios the Little Stinker, a social climber. When Emperor Manuel II Palaeologos (r. 1391–1425) visited the Morea in 1415, Pepagomenos was a doctor in his retinue.
In a 15th-century satire named Mazaris' Journey to Hades, Demetrios Pepagomenos is ridiculed as a doctor who poisoned himself. The text describes him having two sons: Saromates ("Lizard Eyes"), also a doctor, and Theodosios the Little Stinker, a social climber. In 1415, when Emperor Manuel II Palaeologos (r. 1391–1425) visited the Morea, Pepagomenos was part of his medical entourage.