The Cascade Range forms its western boundary with the Palouse regions bordering the area to the east. To the north, the Okanogan–Wenatchee National Forest forms a border with the AVA and Canada. It encompasses the valleys formed by the Columbia River and its tributaries, including the Walla Walla River, the Snake River, and the Yakima River.
The Cascade Range defines the western edge of the area, while the Palouse regions lie to the east. The Okanogan–Wenatchee National Forest borders the region to the north, encompassing valleys formed by the Columbia River and its tributaries, including the Walla Walla River, Snake River, and Yakima River.