On 8 September 2022, Rose was appointed as new RB Leipzig head coach. Two days later, he won his first match 3–0 against his former club Borussia Dortmund in the Bundesliga.
RB Leipzig's new head coach, Rose, was appointed on 8 September 2022. He then achieved a triumphant start to his tenure with a 3–0 win over his previous club Borussia Dortmund in the Bundesliga two days later.