One of his daughters, María, (Moron de la Frontera, 1553–1608) married on 18 March 1570, Juan Fernández de Velasco, 5th Duke of Frías, and their daughter, known as Ana de Velasco y Girón married, on 17 June 1603, the Portuguese 7th Duke of Braganza, Teodósio II, (Vila Viçosa, Portugal, 28 February 1568 – Vila Viçosa, 29 November 1630).
One of his daughters, María (Moron de la Frontera, 1553–1608), married Juan Fernández de Velasco, 5th Duke of Frías, on March 18, 1570. Their daughter Ana de Velasco y Girón, born in Vila Viçosa, Portugal (28 February 1568 – Vila Viçosa, 29 November 1630), married the Portuguese 7th Duke of Braganza, Teodósio II, on June 17, 1603.