A ubiquitous form of the protein in mammals, CALM, (Clathrin-assembly lymphoid myeloid leukaemia protein) is named after its association with myeloid and lymphoid leukemias where some translocations map to this gene. The C-terminus of AP180 is a powerful and specific inhibitor of clathrin-mediated endocytosis.
CALM, a common protein found in mammals, gets its name from its association with myeloid and lymphoid leukemias, where certain chromosomal rearrangements are linked to this gene. The C-terminal region of AP180 is a powerful and specific inhibitor of clathrin-mediated endocytosis.