The Haldane effect relates to the increased affinity of de-oxygenated hemoglobin for : offloading of oxygen to the tissues thus results in increased affinity of the hemoglobin for carbon dioxide,  and , which the body needs to get rid of, which can then be transported to the lung for removal. Because the formation of this compound generates hydrogen ions, haemoglobin is needed to buffer it.
The Haldane effect relates to the increased affinity of de-oxygenated hemoglobin for: offloading of oxygen to tissues, thus resulting in increased affinity of hemoglobin for carbon dioxide, which the body needs to get rid of, which can then be transported to the lung for removal. Because the formation of this compound generates hydrogen ions, haemoglobin is needed to buffer it.