2-AG was discovered by Raphael Mechoulam and his student Shimon Ben-Shabat. 2-AG was a known chemical compound but its occurrence in mammals and its affinity for the cannabinoid receptors were first described in 1994–1995.
Raphael Mechoulam and his student Shimon Ben-Shabat identified 2-AG, which had previously been known as a chemical substance but was only then discovered to be present in mammals and interact with cannabinoid receptors. This discovery occurred between 1994 and 1995.