In the central nervous system, Apo-E is mainly produced by astrocytes and transports cholesterol to neurons via APOE receptors, which are members of the low density lipoprotein receptor gene family. Apo-E is the principal cholesterol carrier in the brain.
In the central nervous system, Apo-E is mainly produced by astrocytes and transports cholesterol to neurons via APOE receptors, which are part of the same gene family as the low-density lipoprotein receptor. Apo-E acts as a primary carrier of cholesterol in the brain.