Once the tumor is seeded in the bone, the tumor cells stimulate bone resorption by secreting factors such as RANKL or prompting the surrounding stroma to express growth factors. These growth factors then upregulate production of RANKL which leads to osteoclastogenesis and bone destruction.
When a tumor is implanted in the bone, it stimulates bone resorption through the secretion of substances like RANKL or by prompting the surrounding stroma to produce growth factors. These growth factors then enhance RANKL levels, leading to osteoclast formation and bone degradation.