Lake Monroe is one of the lakes that make up the St. Johns River system. The port city of Sanford is situated along the southern shore, while DeBary and Deltona are located along the northern shore.
In the context of the St. Johns River system, Lake Monroe plays a role as one of its constituent lakes. The port city of Sanford is positioned on the lake's southern shoreline, whereas the towns of DeBary and Deltona are situated on its northern shoreline.