These two receptor isoforms dimerize upon binding the PDGF dimer, leading to three possible receptor combinations, namely -αα, -ββ and -αβ. The extracellular region of the receptor consists of five immunoglobulin-like domains while the intracellular part is a tyrosine kinase domain. The ligand-binding sites of the receptors are located to the three first immunoglobulin-like domains.
The two receptor isoforms dimerize upon PDGF binding, resulting in three possible combinations: -αα, -ββ and -αβ. These receptors have a five-domain extracellular region and a tyrosine kinase domain. The ligand-binding sites are located on the first three immunoglobulin-like domains.