Rome finished the 2010–11 season with an NHL career-high 56 games with a goal and four assists. In the 2011 playoffs, he scored his first NHL post-season goal against Antti Niemi of the San Jose Sharks in Game 2 of the third round – a 7–3 win. The following game, he was injured off a boarding hit from Sharks forward Jamie McGinn.
Rome's outstanding performance in the 2010–11 season included setting an NHL record for most games played with 56 contests and achieving a career-best scoring average with a goal and four assists per game. In the playoffs, he made a significant contribution by scoring his first postseason goal against Antti Niemi of the San Jose Sharks in Game 2 of the third round – a resounding 7–3 win. However, his progress was cut short in the next game when he suffered an injury after being hit by Jamie McGinn of the Sharks.