Corticosteroids inhibit inflammatory cytokines, chemokines, adhesion molecules, and other inflammatory mediators. They also reduce synthesis of histamine, stabilize cell membranes, and inhibit degranulation of mast cells. Recent work suggests that the activated corticosteroid-GR complex also elicits nongenomic effects, particularly the inhibition of vasodilation, vascular permeability, and migration of leukocytes.
Corticosteroids suppress inflammation by blocking the action of inflammatory mediators like cytokines, chemokines, adhesion molecules, and histamine. They also stabilize cell membranes and inhibit mast cell degranulation. Recent research indicates that activated corticosteroid-GR complexes can have additional effects beyond gene expression, such as inhibiting vasodilation, vascular permeability, and leukocyte migration.