At the dose that can reduce cocaine intake, most of the analogs require a high DAT occupancy. This would mean that the agonists would need to be behaviorally active at the dose that can bring about reductions in cocaine craving. Most of the analogs will readily substitute for cocaine, although most do not elicit as many lever responses per session because of pharmacokinetic factors.
When this dosage reduces cocaine consumption, most analogs need a high DAT occupancy. This implies that agonists must be behaviorally active at the same dose that decreases cocaine cravings. Most of these analogs can substitute for cocaine well, though they often do not produce as many lever responses per session due to pharmacokinetic factors.