All of the components of the gamma-secretase complex undergo extensive post-translational modification, especially proteolytic activation; APH-1 and PEN-2 are regarded as regulators of the maturation process of the catalytic component presenilin.
Post-translational modifications, especially proteolytic activation, affect all components of the gamma-secretase complex; APH-1 and PEN-2 play a role in regulating presenilin maturation.