After Alpine Junction, NY 224 and the railroad grade continue southeast, entering the town of Cayuta. Entering the hamlet of Cayuta a short distance after, NY 224 becomes a two-lane industrial highway, intersecting with the southern terminus of CR 12 (Cayuta Road), which connects to the Tompkins County line and becomes CR 135.
After Alpine Junction, NY 224 and the railroad track continue southeast, entering the town of Cayuta. Entering the hamlet of Cayuta a short distance after, NY 224 becomes a two-lane industrial highway, intersecting with the southern terminus of CR 12 (Cayuta Road), which connects to the Tompkins County line and becomes CR 135.