Studies have shown that c-jun is required for progression through the G1 phase of the cell cycle, and c-jun null cells show increased G1 arrest. C-jun regulates the transcriptional level of cyclin D1, which is a major Rb kinase.
Studies have shown that c-jun is necessary for progression into the G1 phase of the cell cycle, and cells without c-jun experience more G1 arrest. C-jun regulates the transcriptional level of cyclin D1, impacting Rb kinase function.