The Interstate then continues to Yreka, intersecting SR 3 and SR 96 before crossing the Klamath River and reaching the Oregon border and the Siskiyou Summit.
As it travels through the region, the Interstate reaches the town of Yreka, where it intersects with other major roads (SR 3 and SR 96) before crossing the Klamath River and entering the state of Oregon at the Siskiyou Summit, a notable mountain pass.