In addition, the presence of thiol-disulphide oxidoreductases in B. subtilis may be beneficial in the secretion of disulphide-bond-containing proteins. Such developments from our understanding of the complex protein translocation machinery of Gram-positive bacteria should allow the resolution of current secretion challenges and make Bacillus species preeminent hosts for heterologous protein production.
The presence of thiol-disulphide oxidoreductases in B. subtilis may be beneficial for the secretion of disulfide-bond-containing proteins, which is a significant finding that could help overcome current challenges in protein secretion and make Bacillus species more suitable hosts for producing foreign proteins.