Deletion of the gene for KDM1A can have effects on the growth and differentiation of embryonic stem cells and is universally lethal in knockout mice. KDM1A gene expression is observed to be upregulated in some cancers, and so KDM1A inhibition has therefore been considered a possible epigenetic treatment for cancer.
The deletion of the KDM1A gene can have significant effects on embryonic stem cell growth and differentiation, and is invariably fatal in mice that lack this gene. Elevated KDM1A expression has been observed in certain cancers, leading researchers to explore KDM1A inhibition as a potential epigenetic approach to treating these diseases.