The BMP-15 gene is located on the X-chromosome and using Northern blot analysis BMP-15 mRNA is locally expressed within the ovaries in oocytes only after they have started to undergo the primary stages of development. BMP-15 is translated as a preproprotein that is composed of a single peptide, which contains a proregion and a smaller mature region.
The BMP-15 gene is situated on the X-chromosome and, using Northern blot analysis, BMP-15 mRNA is localized to the ovaries in oocytes only after they have begun their primary stages of development. The BMP-15 gene is translated into a single-peptide preproprotein containing a proregion and a smaller mature region.