TIM1, TIM4, ICOS, CD3 or DR3 and several molecules from the SLAM family were shown to induce polarization towards TH2. In contrast, CD27 and HVEM promote TH1 polarization.
TIM1, TIM4, ICOS, CD3 or DR3, along with several molecules from the SLAM family, were found to steer T-cell responses towards TH2. Conversely, CD27 and HVEM tend to direct T-cell responses towards TH1.