The following season, he marries Jo for a second time and helps save Meredith from losing her medical license. Midway through season 16, he disappeared to Iowa to see his mom, but it was revealed in the episode "Leave a Light On", Alex reconnected with Izzie, in the weeks leading up to Meredith's trial seeking her medical license to be reinstated. It was during that process that he chose to reach out to Izzie because he wanted to know if she was alive, okay, and willing to be there in person for Meredith's trial.
The following season, Alex marries Jo again and helps Meredith avoid losing her medical license. He then travels to Iowa to visit his mother but later reconnects with Izzie before Meredith's trial where he seeks her presence at the trial.