Another possible explanation may be a defect in Ras/MAPK signaling pathway due to mutation of signaling proteins. Particularly, it was published that about 50% of the EG cases had mutated BRAF V600 E gene and about 21% displayed a mutation in MAP2K1.
An alternative explanation could be a defect in the Ras/MAPK signaling pathway caused by mutations in signaling proteins. It was noted that around 50% of EG cases had mutated BRAF V600E genes, and about 21% exhibited mutations in MAP2K1.