He also found that application of serotonin (5-HT) produces an increase in the frequency and amplitude of spontaneous excitatory postsynaptic potentials in layer V pyramidal cells of the neocortex and transitional cortex by whole-cell recording in rat brain slices.
This research suggests a role for serotonin (5-HT) in regulating neuronal excitability within the neocortical and transitional cortical regions of the rat brain.