The road continues through wooded residential areas, leaving Elsmere and becoming South Dupont Road. The route reaches an intersection with the eastern terminus of Faulkland Road. Following this intersection, DE 100 passes to the east of a cemetery before coming to a junction with DE 48 south of the Cab Calloway School of the Arts and Charter School of Wilmington.
The road traverses through wooded residential neighborhoods, separating Elsmere from South Dupont Road. The route intersects with Faulkland Road's eastern terminus. Following this intersection, DE 100 passes to the east of a cemetery before merging with DE 48 south of the Cab Calloway School and Charter School in Wilmington.