As you move further east, the road becomes somewhat flatter as it often parallels Symmes Creek. Traveling the road from end to end, one will cross Symmes Creek five times and pass through several communities including Ironton, Hecla, Kitts Hill, Aid, Wilgus, Arabia, Waterloo, Cadmus, Gage, Centenary, and Gallipolis.
As you travel eastward, the road becomes flatter as it often follows Symmes Creek.  The route will take you across Symmes Creek five times and pass through several towns including Ironton, Hecla, Kitts Hill, Aid, Wilgus, Arabia, Waterloo, Cadmus, Gage, Centenary, and Gallipolis.