Cerulenin is an antifungal antibiotic that inhibits fatty acid and steroid biosynthesis. It was the first natural product antibiotic known to inhibit lipid synthesis. In fatty acid synthesis, it has been reported to bind in equimolar ratio to b-keto-acyl-ACP synthase, one of the seven moieties of fatty acid synthase, blocking the interaction of malonyl-CoA.
Cerulenin is a natural product antibiotic that inhibits the production of fatty acids and steroids by binding to a key enzyme involved in their synthesis. It specifically blocks the action of b-keto-acyl-ACP synthase, which is one of the seven components of fatty acid synthase, preventing the addition of malonyl-CoA.