For example, Loopy uses samples of torsion angle pairs to generate the initial loop structure then it revises this structure to maintain a realistic shape and closure, while RAPPER builds from one end of the gap to the other by extending the stem with different sampled angles until the gap is closed. Yet another method is the “divide and conquer” approach.
For example, Loopy uses torsion angle pairs to generate the initial loop structure, which it then refines to maintain a realistic shape and closure. In contrast, RAPPER constructs the loop by extending the stem from one end of the gap to the other using various sampled angles until the gap is closed. This approach can be likened to dividing a complex problem into smaller, more manageable parts.