At this point, PA 72 merges onto westbound US 322 and the two routes head north-northwest along a four-lane freeway, reaching an interchange with the southern terminus of PA 117. The road passes over the Lebanon Valley Rail Trail at this interchange.
At this point in the journey, PA 72 merges onto westbound US 322 and travels north-northwest on a four-lane highway, eventually connecting to an interchange with the southern end of PA 117. The road crosses over the Lebanon Valley Rail Trail at this junction.