Abruzzo–Erickson syndrome can be diagnosed on the basis of a complete physical examination (as patients with the syndrome often possess noticeable physical characteristics such as a cleft palate, large protruding ears, and facial asymmetry).
The Abruzzo–Erickson syndrome is typically diagnosed based on a comprehensive medical evaluation, which often reveals distinctive physical characteristics in affected patients, including a cleft palate, prominent ears, and uneven facial features.