DePaul Men's Lacrosse divisional rivals include: Bradley University, University of Chicago, Lake Forest College, Loyola University Chicago, Northern Illinois University, Northwestern University, Western Illinois University and Wheaton College, as well as other GLLL opponents.
Teams that DePaul Men's Lacrosse encounters in their divisional rivals are: Bradley University, University of Chicago, Lake Forest College, Loyola University Chicago, Northern Illinois University, Northwestern University, Western Illinois University, and Wheaton College, as well as other GLLL opponents they compete against.