Hyperproinsulinemia is a disease where insulin is not sufficiently processed before secretion and immature forms of insulin make up the majority of circulating insulin immunoreactivity in both fasting and glucose-stimulated conditions (insulin immunoreactivity refers to all molecules detectable by an insulin antibody, i.e.
Hyperproinsulinemia involves a situation where insulin is not sufficiently processed before release, leading to immature forms of insulin dominating the circulating insulin immunoreactivity in both fasting and glucose-stimulated conditions (where insulin immunoreactivity signifies all molecules that can be detected by an insulin antibody).