In normal tissue, inflammation and the immune response would be limited by secretion of TGF-β. TGF-β on the one hand induces fascin expression, but on the other hand, restricts activity of transcription factor NF-κB.
TGF-β limits inflammation and immune responses in normal tissues. On one side, TGF-β encourages fascin expression; conversely, it restrains NF-κB function.