In April 1956, noretynodrel was investigated, in Puerto Rico, in the first large-scale clinical trial of a progestogen as an oral contraceptive. The trial was conducted in Puerto Rico due to the high birth rate in the country and concerns of moral censure in the United States.
In April 1956, noretynodrel was investigated for its potential use as an oral contraceptive in Puerto Rico, which was part of a large-scale clinical trial that aimed to assess its effectiveness as a contraceptive method. The location of this trial was chosen due to the high birth rate and concerns about moral disapproval in the United States.