The AP2 adaptor complex exists in two primary conformations: the open conformation (active state) and the closed conformation (inactive state). In its active state, the clathrin binding site found on the β subunit and the cargo binding site found on the μ subunit are exposed to the cytosol, allowing their respective interactions to occur.
The AP2 adaptor complex exists in two primary forms: an open conformation (active) and a closed conformation (inactive). In its active state, the β subunit's clathrin binding site and the μ subunit's cargo binding site are exposed to the cytosol, allowing them to interact.