Besides described antiviral effects, IL-29 modulates cytokine production of other cells, for example, it increases secretion of IL-6, IL-8 and IL-10 by monocytes and macrophages, enhances the responsiveness of macrophages to IFN-γ by increased expression of IFNGR1, stimulates T cell polarization towards Th1 phenotype and also B cell response to IL-29 was reported.
Besides its described antiviral effects, IL-29 affects cytokine production in other cells. It boosts the secretion of IL-6, IL-8, and IL-10 by monocytes and macrophages, enhances macrophage responsiveness to IFN-γ through increased expression of IFNGR1, stimulates T cell polarization towards a Th1 phenotype, and also indicates B cell responses to IL-29.