After intersecting 29th Street, SH 208 travels through less developed areas of the city then leaves the San Angelo city limits just south of an intersection with FM 2105. Leaving San Angelo, the highway's route becomes rural and sparsely populated, traveling by several farms and ranches.
After crossing 29th Street, SH 208 travels through less inhabited areas within the city before exiting San Angelo's boundaries south of an intersection with FM 2105. After leaving San Angelo, the highway route becomes rural and sparsely populated, passing by several farms and ranches.