In the human, the channel is activated by progesterone released by the oocyte. Progesterone binds to the protein ABHD2 which is present in the sperm plasma membrane, which causes ABHD2 to cleave an inhibitor of CatSper (2-arachidonoylglycerol) into arachidonic acid and glycerol.
In humans, the channel is activated by progesterone released from the oocyte. Progesterone binds to the protein ABHD2 present in the sperm plasma membrane, causing ABHD2 to cleave an inhibitor of CatSper (2-arachidonoylglycerol) into arachidonic acid and glycerol.