In cancer studies, Fenretinide treatment may cause ceramide (a wax-like substance) to build up in tumor cells and is associated with the accumulation of reactive oxygen species (ROS), resulting in cell death through apoptosis and/or necrosis. Fenretinide accumulates preferentially in fatty tissue such as the breast, which may contribute to the effectiveness of fenretinide against breast cancer.
In cancer research, Fenretinide treatment can lead to ceramide accumulation and ROS buildup within tumor cells, potentially causing cell death through apoptosis or necrosis. This mechanism might be enhanced by Fenretinide's concentration in fatty tissues like the breast, contributing to its effectiveness against breast cancer.