Thrombembolic MCAO is achieved either by injecting clots that were formed in vitro or by endovascular instillation of thrombin for in situ clotting . The thrombembolic model is closest to the pathophysiology of human cardioembolic stroke.
Thromboembolic Middle Cerebral Artery Occlusion (MCAO) can be induced through either injecting clots that were previously created in a lab setting or by using thrombin to induce clotting directly within the blood vessel. The thromboembolic model is most closely related to how human cardioembolic strokes occur.