The Andean region, located in central Colombia, is the most populated natural region of Colombia. With many mountains, the Andes contain most of the country's urban centers. They were also the location of the most significant pre-Columbian  indigenous settlements.
In terms of natural regions, the Andean area in central Colombia is particularly notable for being the most populous. The presence of mountains has led to the development of many cities and urban hubs within the region. This area also played a significant role in pre-Columbian history with its indigenous settlements.