During the reign of his successor, Đurađ Branković, the monastery was dedicated to the Saint Stephen, the saint protector of the Branković dynasty. The prosperity of the monastery was disrupted after the Ottoman conquest of Serbia in 1459. Ottomans killed 30 students in the monastery but the relics were partially moved to the Vojlovica monastery in then Hungary, across the Danube.
During Đurađ Branković's reign, the monastery was dedicated to Saint Stephen, the saintly protector of the Branković dynasty. After Serbia fell to the Ottomans in 1459, the monastery's prosperity declined. The Ottomans killed 30 students at the monastery but some relics were moved to Vojlovica Monastery in then-Hungary across the Danube.