In the original Louisiana Highway system in use between 1921 and 1955, the modern LA 52 was originally designated as part of State Route 2, which followed the Old Spanish Trail auto trail throughout the state of Louisiana. In 1926, it became part of the original route of US 90, which duplicated Route 2 throughout the state.
In the early days of the Louisiana highway system (1921-1955), the modern LA 52 was initially designated as part of State Route 2, tracing the Old Spanish Trail across Louisiana. In 1926, it merged with US 90's original route, duplicating its path throughout the state.