Thus, the conformation of Leu41 is determined by the presence of water and the oxidation state of rubredoxin. The proximity of water to the [Fe(S-Cys)4] 2- active site stabilizes the higher net negative charge of the Fe2+ oxidation state.
The conformation of Leu41 is influenced by the presence of water and the oxidation state of rubredoxin, with water's proximity to the [Fe(S-Cys)4] 2- active site stabilizing the higher net negative charge of the Fe2+ oxidation state.