This also produces translational attenuation of the protein machinery involved in running the cell cycle, producing cell cycle arrest in the G1 phase. PERK deficiency may have a significant impact on physiological states associated with ER stress.
The suppression of translational processes in the protein machinery associated with the cell cycle leads to cell cycle arrest in the G1 phase. PERK deficiency might have a considerable impact on physiological states tied to ER stress.