Over time, these pigment cells can accumulate in the anterior chamber in such a way that they begin to clog the trabecular meshwork (the major site of aqueous humour drainage), which can in turn prevent the aqueous humour from draining and therefore increases the pressure inside the eye. A common finding in PDS are central, vertical corneal endothelial pigment deposits, known as Krukenberg spindle.
As pigment cells accumulate over time in the anterior chamber, they can block the trabecular meshwork, which drains aqueous humor. This blockage prevents proper drainage and increases pressure within the eye. A common finding in primary angle-closure glaucoma (PDS) is central, vertical corneal endothelial pigment deposits known as Krukenberg spindle.