Past Prattsburgh, NY 53 continued north on State Road, McMichael Road, Wetmore Road, Italy Hill Road, Italy Friend Road, Friend Road, and modern NY 247 before terminating at a junction with US 20 and NY 5 east of Canandaigua.
From Prattsburgh, New York, Route 53 continued north on State Road, McMichael Road, Wetmore Road, Italy Hill Road, Italy Friend Road, Friend Road, and finally onto modern NY 247 before reaching a junction with US 20 and NY 5 east of Canandaigua.