They supplied designs to the department stores Biki and later, La Rinascente in Milan, where in 1958, the first Missoni-labelled garments, a line of colourful vertically striped shirtdresses, were displayed in the window. Ottavio's experience as an activewear designer and manufacturer was applied to his and Rosita's designs, which contributed significantly to the development of Italian sportswear as a challenge to the American industry.
They provided designs to department stores Biki and later, La Rinascente in Milan. In 1958, they showcased the first Missoni-labelled garments – a line of vibrant vertically striped shirtdresses – in store windows. Ottavio's expertise as an activewear designer and manufacturer was utilized in their creations, which played a crucial role in advancing Italian sportswear as a response to American industry.