Protopadakis was elected to the Hellenic Parliament in 1902 as a member of the conservative Nationalist Party. He later joined the People's Party and served as Minister of Economy and later, in the government of Dimitrios Gounaris, he was the Justice Minister (1921–22).
Protopadakis was elected to the Hellenic Parliament in 1902 as a member of the conservative Nationalist Party. He later joined the People's Party and served as Economy Minister and Justice Minister under Dimitrios Gounaris from 1921 to 1922.