Some experts have cautioned that it remains to be proved that a good response to exogenous androgens in neonates is a good predictor of androgen response at puberty. If a mutation in the AR gene is found, it is important to determine whether the mutation is inherited or de novo (i.e.
Some experts have cautioned that it remains unclear whether a positive reaction to exogenous androgens in infants indicates a good predictor for androgen responses during puberty. If a mutation in the AR gene is discovered, it's important to ascertain whether the mutation is passed down through generations or developed anew.