RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of spinal and bulbar muscular atrophy.
This statement describes a connection between RAN, AR, polyglutamine expansion, androgen insensitivity, and spinal and bulbar muscular atrophy (SBMA). The diminished coactivation of RAN with AR due to polyglutamine expansion within the AR is thought to contribute to partial androgen insensitivity during SBMA development.