Phosphatidylethanolamine has also shown to be able to propagate infectious prions without the assistance of any proteins or nucleic acids, which is a unique characteristic of it. Phosphatidylethanolamine is also thought to play a role in blood clotting, as it works with phosphatidylserine to increase the rate of thrombin formation by promoting binding to factor V and factor X, two proteins which catalyze the formation of thrombin from prothrombin. The synthesis of endocannabinoid anandamide is performed from the phosphatidylethanolamine by the successive action of 2 enzymes, the N-acetyltransferase and phospholipase-D.
Phosphatidylethanolamine has demonstrated the ability to transmit infectious prions without the aid of proteins or nucleic acids, a characteristic that sets it apart. Furthermore, it is believed to contribute to blood clotting by collaborating with phosphatidylserine to accelerate thrombin formation through enhanced binding affinity for factor V and factor X.