It forms the main road from Warwick to Leamington, crossing into the latter town at the Portobello Bridge over the River Avon near that river's junction with the River Leam. Just east of the bridge the A445 has a junction with the B4099 with the B route heading into central Leamington and the A445 skirting the north of the town.
The main road from Warwick to Leamington is a significant route connecting these two towns, crossing over the River Avon near its confluence with the River Leam. The A445 intersects with the B4099 at a key location east of the bridge, leading into central Leamington and skirting the northern edge of the town.