IL-17F is able to induce several cytokines, chemokines and adhesion molecules in bronchial epithelial cells, vein endothelial cells, fibroblasts and eosinophils. IL-17F utilizes IL-17RA and IL-17RC as its receptors and activates the MAP kinase-related pathway. IL-17F is derived from several cell types such as Th17 cells, mast cells and basophils, and shows a wide tissue expression pattern including lung.
IL-17F triggers numerous cytokines, chemokines, and adhesion molecules in bronchial epithelial cells, vein endothelial cells, fibroblasts, and eosinophils. It uses IL-17RA and IL-17RC as receptors and activates the MAP kinase-related pathway. Derived from Th17 cells, mast cells, and basophils, IL-17F displays a wide tissue expression pattern in lungs.