In the 1452 bull Ex apostolice sedis, Pope Nicholas V confirmed once more Ferdinand's appointment and put a definitive end to questions (up to then still being raised by Castile) about the autonomy of the Portuguese branch of Santiago.
Pope Nicholas V, in the 1452 bull Ex apostolice sedis, confirmed Ferdinand's position again and concluded all previous uncertainties (which had been posed by Castile up until that point) concerning the independence of the Portuguese section of Santiago.