The pharmacology of a given P2X receptor is largely determined by its subunit makeup. Different subunits exhibit different sensitivities to purinergic agonists such as ATP, α,β-meATP and BzATP; and antagonists such as pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid (PPADS) and suramin.
The activity of a P2X receptor is influenced by the specific subunits it contains. These subunits have different responses to purinergic agonists like ATP, α,β-meATP, and BzATP, as well as antagonists such as PPADS and suramin.