ASP has neuroendocrine functions consistent with murine agouti, as it agonizes via AgRP neurons in the hypothalamus and antagonizes MSH at MC4Rs which reduce satiety signals. AgRP acts as an appetite stimulator and increases appetite while decreasing metabolism.
ASP has physiological roles similar to those of the murine agouti, working through AgRP neurons in the hypothalamus to activate appetite and counteract MSH at MC4Rs, which reduces hunger signals. AgRP functions as an appetite enhancer that boosts appetite while reducing metabolic rate.