Due to its ability to activate or inactivate thyroid hormone, Dio3 coding of D3 could be a target for therapeutic intervention in insulin-related illness such as diabetes. In addition, an abnormal amount of Dio3 related to insufficient thyroid hormone levels could be responsible for the disruption of brain development in conjunction with alcohol exposure.
The capacity of Dio3 coding of D3 to influence thyroid hormone activity suggests it could serve as a treatment target for conditions like diabetes that involve insulin. Additionally, excessive Dio3 levels tied to insufficient thyroid hormones may disrupt brain development when combined with alcohol exposure.