As an immunosuppressive cytokine, IL-19 promotes the Th2 (regulatory) T-cell response which supports an anti-inflammatory lymphocyte phenotype, dampens the Th1 T-cell response and inflammatory cytokine secretion (IFNγ), increases IL-10 (anti-inflammatory) expression in peripheral blood mononuclear cells (PBMC), and inhibits the production of immunoglobulin G (IgG) from B cells.
As an immunosuppressive cytokine, IL-19 stimulates the Th2 (regulatory) T-cell response that fosters a non-inflammatory lymphocyte profile, suppresses the Th1 T-cell response and inflammatory cytokine secretion (IFNγ), enhances IL-10 (anti-inflammatory) expression in peripheral blood mononuclear cells (PBMC), and restrains immunoglobulin G (IgG) production from B cells.