As of 2017, Ctenophryne includes two other genera, Nelsonophryne and Melanophryne, in synonymy. The latter might represent valid genera, but molecular analyses could not resolve their relationships in a robust way.
The classification of Ctenophryne includes two additional genera, Nelsonophryne and Melanophryne, which are currently considered potentially valid genera. However, further research is needed to clarify their evolutionary relationships through molecular analysis.