LAD1, a subtype of LAD, is caused by a lack of integrins that contain the beta subunit, including LFA-1. LAD1 is characterized by recurring bacterial infection, delayed (>30 days) separation of umbilical cord, ineffective wound healing and pus formation, and granulocytosis. LAD1 is caused by low expression of CD11 and CD18.
LAD1, a subtype of LAD, results from a lack of integrins that contain the beta subunit, including LFA-1. This condition is characterized by recurring bacterial infections, delayed separation of the umbilical cord, impaired wound healing, pus formation, and granulocytosis. The low expression of CD11 and CD18 is a key factor in the development of LAD1.