Mice that lack Syk completely (Syk−/−, Syk-knockout) die during embryonic development around midgestation. They show severe defects in the development of the lymphatic system. Normally, the lymphatic system and the blood system are strictly separated from each other.
During embryonic development near midgestation, mice lacking Syk (Syk−/−, Syk-knockout) succumb to death. These animals display severe issues with lymphatic system formation. Normally, the lymphatic and blood systems remain distinctly separate.