SR 333 begins in Friendsville at an intersection with US 321/SR 73 just southeast of downtown. It goes northwest as E Main Avenue to enter downtown, where it turns right onto N Farnum Street to pass through town before turning left onto Miser Station Road, where it leaves Friendsville and continues northeast.
SR 333 starts in Friendsville at an intersection with US 321/SR 73 just southeast of downtown. It heads northwest along E Main Avenue into the city center, where it turns right onto N Farnum Street to pass through town before turning left onto Miser Station Road, marking its departure from Friendsville and continuing northeast.