NY 220 passes into the town of McDonough and enters a hamlet bearing the same name, where it turns eastward. The route winds its way through the eastern, forested portion of the town to the small community of East McDonough, located near the McDonough–Preston town line.
NY 220 travels into the town of McDonough and enters a hamlet with the same name, then heads east. The route meanders through the eastern, forested area of the town to the small community of East McDonough, which is close to the McDonough–Preston town line.