MD 366 is the main east–west highway of southern Worcester County, connecting US 13 in Pocomoke City with MD 12 in Stockton. The state highway was constructed starting in the mid-1910s from the Pocomoke City end.
MD 366 is the primary east-west road that spans southern Worcester County, linking US 13 in Pocomoke City with MD 12 in Stockton. The state highway was constructed starting in the early 1910s from its eastern terminus in Pocomoke City, providing a vital transportation link for the area.