Circulatory effects of carpaine were studied in Wistar male rats weighing 314 +/- 13 g, under pentobarbital (30 mg/kg) anesthesia. Increasing dosages of carpaine from 0.5 mg/kg to 2.0 mg/kg resulted in progressive decrease in systolic, diastolic, and mean arterial blood pressure. Selective autonomic nervous blockade with atropine sulfate (1 mg/kg) or propranolol hydrochloride (8 mg/kg) did not alter the circulatory response to carpaine.
The effects of carpaine on circulation were analyzed in Wistar male rats weighing 314 +/- 13 g under pentobarbital anesthesia. Increasing carpaine doses from 0.5 mg/kg to 2.0 mg/kg caused a decline in systolic, diastolic, and mean arterial blood pressure. Neither atropine sulfate (1 mg/kg) nor propranolol hydrochloride (8 mg/kg) modified the circulatory response to carpaine.