This property distinguishes it from a pure HILIC (hydrophilic interaction chromatography) columns where separation by polar differences is obtained through partitioning into a water-rich layer on the surface, or a pure RP stationary phase on which separation by nonpolar differences in solutes is obtained with very limited secondary mechanisms operating.
This characteristic sets it apart from pure HILIC columns, which separate molecules based on polar differences through partitioning into a water-rich layer or a nonpolar RP stationary phase, with minimal secondary mechanisms involved.