If applied rectally, Cmax is reached after four hours. The bioavailability of the suppositories, measured as area under the curve (AUC), is about twofold that of oral formulations, due to a first pass effect of over 50%.
If administered rectally, Cmax occurs after four hours. The bioavailability of the suppositories, expressed through AUC, is about twice as much as oral formulations, because of a significant first-pass effect.