Sensitization, a form of reverse tolerance, develops rapidly to the positive, euphoric effects of alcohol, but not to the physical effects, such as sedation and respiratory depression, which diminish with prolonged use. This sensitization does not occur, however, with administration of benzodiazepines or neuroactive steroids, which only exhibit weakening of effect with repeated use.
Sensitization, a form of reverse tolerance, rapidly becomes accustomed to the euphoric effects of alcohol but not to its physical impacts like sedation and respiratory depression. These physical effects diminish with continued use, while sensitization does not occur with benzodiazepines or neuroactive steroids, which only exhibit a weakening effect over time.