After founding of nearby Hermoupolis, Ano Syros ceased to be the administrative centre of Syros. Nevertheless, the settlement remained a religious centre since it is the seat of Roman Catholic Diocese of Syros and Milos.
The founding of Hermoupolis led to Ano Syros losing its administrative role in Syros.  However, it continued to be a significant religious center because it is the headquarters for the Roman Catholic Diocese of Syros and Milos.