This leads to morphological changes, abnormal mitogenic signals and sustained activity can result in apoptosis of the host cell. Epidemiological studies have shown roles of cagA- positive H. pylori in the development of atrophic gastritis, peptic ulcer disease and gastric carcinoma.
The presence of cagA-positive H. pylori leads to morphological changes, abnormal mitogenic signals, and sustained activity, which can ultimately result in apoptosis of the host cell. Epidemiological studies have shown that this bacterium is associated with the development of atrophic gastritis, peptic ulcer disease, and gastric carcinoma.