Although vertebrate DSCAMs lack the diversity of their invertebrate counterparts, the selective transcription of individual Pcdh isoforms can be achieved by promoter choice followed by alternative pre-mRNA cis-splicing thus increasing the number of possible combinations.
Despite having fewer diverse isoforms compared to invertebrates, vertebrate DSCAMs can still generate different isoforms by selecting promoters and using alternative pre-mRNA splicing, thus creating a larger range of possible combinations.