When the Takeda clan invaded their territory in 1553, the Takanashi allied with the Murakami, Ogasawara, and Suda clans. However, they all turned to Uesugi Kenshin of Echigo Province for assistance.
Upon the Takeda invasion of their land in 1553, the Takanashi formed an alliance with the Murakami, Ogasawara, and Suda clans. Nonetheless, they sought support from a prominent leader, Uesugi Kenshin of Echigo Province.