In mammals, chromodomain-containing proteins are responsible for aspects of gene regulation related to chromatin remodeling and formation of heterochromatin regions. Chromodomain-containing proteins also bind methylated histones and appear in the RNA-induced transcriptional silencing complex. In histone modifications, chromodomains are very conserved.
In mammals, proteins containing a chromo domain play a role in regulating genes related to chromatin remodeling and heterochromatin formation. These proteins also interact with methylated histones and are part of the RNA-induced transcriptional silencing complex. The structure of these domains is highly conserved across different histone modifications.