Phenytoin can worsen seizures and may speed up neurodegeneration; carbamazepine, oxcarbazepine, tiagabine, vigabatrin, gabapentin and pregabalin may worsen myoclonus and myoclonic seizures. Other common medications to treat ULD include topiramate and zonisamide.
Phenytoin can increase the risk of seizures and accelerate brain damage; carbamazepine, oxcarbazepine, tiagabine, vigabatrin, gabapentin, and pregabalin may worsen myoclonus and myoclonic seizures. Other medications frequently used to treat ULD include topiramate and zonisamide.