More recently, it has been shown that Cxcl3 regulates cell autonomously the migration of the precursors of cerebellar granule neurons toward the internal layers of cerebellum, during the morphogenesis of cerebellum. Moreover, if the expression of Cxcl3 is reduced in cerebellar granule neuron precursors, this highly enhances the frequency of the medulloblastoma, the tumor of cerebellum.
Lately, research has revealed that Cxcl3 plays a crucial role in guiding cerebellar granule neuron precursors towards their designated positions within the cerebellum during its development. Additionally, reduced levels of Cxcl3 in these precursor cells have been linked to an increased incidence of medulloblastoma.