Donnolo is one of the earliest Jewish writers on medicine, and one of the few Jewish scholars of Southern Italy at this early time. What remains of his medical work, Sefer ha-Yaqar "Precious Book", was published by Moritz Steinschneider in 1867, from MS. 37, Plut.
Donnolo is a prominent example of an early Jewish scholar in medicine, and one of the few from Southern Italy to have left a lasting legacy at that time. His medical treatise, "Sefer ha-Yaqar", was later edited by Moritz Steinschneider in 1867.