US 6 turns off Southwest Highway in Orland Park, heads north on Wolf Road briefly, then turns east onto 159th Street, a major east–west arterial through that town and the southern suburbs of Chicago.
US 6 leaves Southwest Highway in Orland Park, moves north on Wolf Road for a short distance, and then turns east onto 159th Street, which serves as a major east-west artery through the town and its surrounding suburban areas.