In order for apoptosis to begin, an enzyme called caspase 3 cleaves ICAD so that CAD becomes activated. CAD then cleaves the DNA between nucleosomes, which occur in chromatin at 180 base pair intervals.
In order for apoptosis to commence, an enzyme called caspase 3 cuts ICAD so that CAD becomes activated. CAD subsequently cuts the DNA between nucleosomes, which are found in chromatin at intervals of 180 base pairs.