Class I hydrophobins are characterised by having a quite diverse amino acid sequence between different types (with exception of the conserved cysteine residues), and compared to class II, they have long, varied inter-cysteine spacing.
The classification of hydrophobins is based on their amino acid sequences, which are diverse among different types except for the presence of conserved cysteine residues. Class I hydrophobins have longer inter-cysteine distances compared to class II.