However, most of these drugs are experimental and operate in a non-specific manner, potentially influencing sodium channel kinetics as well as dopamine synthesis. Novel T-type calcium channel inhibitors have recently been discovered which more selectively target the CaV3.3 channel sub-type expressed in central motor neurons, showing robust modulation in a rodent and primate models of Parkinson's disease.
However, most of these drugs are experimental and act in a non-specific manner, possibly affecting sodium channel kinetics as well as dopamine synthesis. Recently discovered novel T-type calcium channel inhibitors have been identified which more selectively target the CaV3.3 channel subtype expressed in central motor neurons, demonstrating strong modulation in rodent and primate models of Parkinson's disease.