Solubility: A common challenge in fusion protein design is the issue of insolubility of newly synthesized fusion proteins in the recombinant host, leading to an over-aggregation of the target protein in the cell.
Solubility: One common hurdle in designing fusion proteins involves the difficulty of these newly synthesized fusion proteins remaining soluble in the recombinant host, leading to an over-aggregation of the target protein inside the cell.