CXCR2 receptor for CXCL1 is expressed in the brain and spinal cord by neurons and oligodendrocytes and during CNS pathologies such as Alzheimer's disease, multiple sclerosis and brain injury also by microglia. An initial study in mice showed evidence that CXCL1 decreased the severity of multiple sclerosis and may offer a neuro-protective function.
CXCR2 receptor for CXCL1 is expressed in the CNS by various cell types, including neurons, oligodendrocytes, microglia, and during diseases such as Alzheimer's, multiple sclerosis, and brain injury. A study on mice found that CXCL1 may reduce the severity of multiple sclerosis and offer neuroprotective benefits.