These poor quality V𝛽 RSSs decreased the chances of upstream V𝛽 and V31 recombination on the same allele, which in turn enabled functional TCR𝛽 genes’ monoallelic assembly and expression. However, poor quality V𝛽 RSSs were unlikely to result in monogenic TCR𝛽 expression alone and might have involved other epigenetic processes.
The presence of low-quality V𝛽 RSSs reduced the likelihood of upstream V𝛽 and V31 recombination on the same allele, which facilitated functional TCR𝛽 gene monoallelic assembly and expression. However, these poor quality V𝛽 RSSs were unlikely to solely result in monogenic TCR𝛽 expression and might have been involved in other epigenetic processes.