These cytokines induce the activation of transcription factors which push completion of the monoblast's myeloid cell fate. Monoblasts are normally found in bone marrow and do not appear in the normal peripheral blood. They mature into monocytes which, in turn, develop into macrophages.
These cytokines trigger the activation of transcription factors that drive the development of a monoblast into a myeloid cell. Monoblasts reside primarily in the bone marrow and are absent from the bloodstream. These cells mature into monocytes, which subsequently transform into macrophages.