This glucocorticoid-inactivating enzyme is also expressed in tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, as well as parts of the developing brain, including the rhombencephalic progenitor cells that proliferate into cerebellar granule cells.
This enzyme that disables glucocorticoids is also present in tissues without mineralocorticoid receptors, like the placenta and testes, as well as areas of the developing brain, particularly precursor cells that mature into cerebellar granule neurons.