However, people whose CrCl levels are less than 50ml/min should not follow this dosage. Instead, patients should be prescribed drug components of the fixed-dose combinations while adjusting TDF and FTC doses according to the patient's CrCl levels.
Individuals with low CrCl levels (less than 50 ml/min) require a different dosage regimen compared to those with normal CrCl levels.  Fixed-dose combinations are used, and TDF and FTC doses are adjusted based on the patient's CrCl level.