Upon reaching the east bank of the Susquehanna River, the route enters the town of Perryville and passes over residential areas and Norfolk Southern's Port Road Branch railroad line before descending off the Thomas J. Hatem Memorial Bridge, where it passes a pair of weigh stations. US 40 becomes state-maintained again and follows four-lane divided Pulaski Highway northeast to an intersection with MD 222. Following this, the road passes through business areas with some woodland to the south.
Upon arriving at the eastern bank of the Susquehanna River, the route enters the town of Perryville and traverses through residential districts and Norfolk Southern's Port Road Branch railroad line before dropping down from the Thomas J. Hatem Memorial Bridge, where it passes a pair of weigh stations. US 40 becomes state-maintained once more and follows four-lane divided Pulaski Highway northeast to an intersection with MD 222. Following this, the road passes through commercial areas with some woodland to the south.