In humans, excess accumulation of intramuscular fat has been associated with conditions such as insulin resistance and type 2 diabetes. The human immunodeficiency virus (HIV)-lipodystrophy syndrome is associated with over-accumulation of intramuscular fat, which may contribute to AIDS wasting syndrome.
Excess intramuscular fat accumulation in humans is associated with conditions like insulin resistance and type 2 diabetes, and the HIV-lipodystrophy syndrome is characterized by this same phenomenon.  This excess fat may contribute to AIDS wasting syndrome.