HEVs enable naïve lymphocytes to move in and out of the lymph nodes from the circulatory system. HEV cells express addressins, which are specific adhesion molecules that attach to the L-selectins on lymphocytes and anchor them to the HEV wall in preparation for crossing the endothelium.
High endothelial venules (HEVs) facilitate the movement of naive lymphocytes into and out of lymph nodes from the bloodstream. These vessels express addressins, which are specialized adhesion molecules that bind to L-selectins on lymphocytes, anchoring them to the HEV wall for crossing the endothelium.