The RRM domain in its carboxylic region attaches to the SMAD (protein) proteins, which is involved in mediating TGF-β cellular signalling. Consequently, LEMD3 indirectly regulates downstream genes.
The RRM domain within the protein binds to SMAD proteins located in its carboxyl end, contributing to TGF-β cellular signaling. As a consequence, LEMD3 influences the expression of downstream genes indirectly.