The main line runs through the south-eastern region of Botswana from Mahikeng in South Africa through Lobatse, Gaborone, Mahalapye, Palapye and Francistown to Plumtree in Zimbabwe.
The main route traverses the southeastern region of Botswana, starting in Mahikeng, South Africa, and extending through Lobatse, Gaborone, Mahalapye, Palapye, and Francistown to Plumtree, Zimbabwe.