Jeffersonia diphylla is native to Eastern North America where it is found from Minnesota east to New York and south to Tennessee. In Minnesota it grows in the lower southeastern section of the state in mesic deciduous forests and most commonly in ravines or on talus slopes.
Jeffersonia diphylla's range covers Eastern North America, from Minnesota to New York and down to Tennessee. In Minnesota, it typically grows in the southeastern region's moist deciduous forests and often appears on ravine slopes or talus areas.