All species in this genus are very similar. Until recently, this genus was considered to be composed of only two species, however the Flora of North America recognizes Caulophyllum giganteum, as a distinct species rather than a subspecies of Caulophyllum thalictroides.
All members of this genus share significant similarities. Until recently, it was thought that this genus contained only two species; however, the Flora of North America has reclassified Caulophyllum giganteum as a distinct species rather than a subspecies of Caulophyllum thalictroides.