Therefore, unlike syndecans the heparan sulfate glycosaminoglycan chains attached to glypicans are located rather close to the cell-membrane. The glypicans found in vertebrates, Drosophila, and C. elegans all have an N-terminal signal sequence.
Consequently, unlike syndecans, the heparan sulfate glycosaminoglycan chains attached to glypicans are situated relatively near the cell membrane. The glypicans found in vertebrates, Drosophila, and C. elegans all possess an N-terminal signal sequence.