Defending champion Rafael Nadal defeated Roger Federer in the final, 1–6, 6–1, 6–4, 7–6(7–4) to win the men's singles tennis title at the 2006 French Open.
In the final round, Rafael Nadal, as the defending champion, defeated Roger Federer in a match that concluded with scores of 1–6, 6–1, 6–4, and 7–6(7–4), winning the men's singles tennis title at the 2006 French Open.