MFP1 inhibits and MFP2 stimulates the MSP assembly. Changes in pH both controls and activates the MSP polymerization throughout spermatogenesis by a pH gradient within the pseudopod of the spermatozoon: assembly occurs at the leading edge where the pH is high, and disassembly of the filaments occurs at the base where the pH is lowered. Degradation of the MSP filaments results in a traction force at the base of the pseudopod, which in turn pulls the cytoskeleton forward.
MFP1 inhibits and MFP2 stimulates the MSP assembly. Changes in pH both controls and activates the MSP polymerization throughout spermatogenesis by a pH gradient within the pseudopod of the spermatozoon: assembly occurs at the leading edge where the pH is high, and disassembly of the filaments occurs at the base where the pH is lowered. Degradation of the MSP filaments results in a traction force at the base of the pseudopod, which in turn pulls the cytoskeleton forward.