John Paul II accepted Holguín's resignation from episcopal duties in 2003, when Holguín was aged 75. Since his retirement, he dedicated himself to the service of Opus Dei, and to the creation of numerous religious and legal works.
In 2003, Pope John Paul II accepted Holguín's resignation from his position as a bishop due to his age (75 years old). After retiring, he dedicated himself to serving Opus Dei and producing various religious and legal publications.