While the mechanisms underlying the sustained over-expression of ASNS have not been reported in these studies, transcriptome profiling of two T-ALL patients that have relapsed after L-asparaginase treatment revealed a recurrent promoter swap with KMT2E leading to ASNS over-expression and L-asparaginase resistance.
In the absence of detailed explanations for sustained ASNS over-expression in these studies, transcriptome analysis of two T-ALL patients who relapsed after L-asparaginase treatment revealed a consistent genetic swap involving KMT2E that resulted in increased ASNS expression and L-asparaginase resistance.