A mutation of the IRF6 gene can lead to the autosomal dominant van der Woude syndrome (VWS)  or the related popliteal pterygium syndrome (PPS). Van der Woude syndrome can include cleft lip and palate features along with dental anomalies and lip fistulas.
Mutations in the IRF6 gene are linked to van der Woude syndrome (VWS), which is characterized by cleft lip and palate, dental anomalies, and lip fistulas.  Popliteal pterygium syndrome (PPS) is a related condition that can also be caused by mutations in the same gene.