The activity of Ψ-DOM (and Ψ-2C-T-4) demonstrates that the two methoxy groups on the psychedelic phenethylamines are not strictly limited to the 2,5-positions on the phenyl ring. Indeed, any of the 2Cx or DOx series of drugs could alternatively be made as the 2,6-isomer and would still be expected to show similar activity, although slightly less potent.
The effectiveness of Ψ-DOM (and Ψ-2C-T-4) indicates that the two methoxy groups on psychedelic phenethylamines are not restricted to the 2,5-positions within the phenyl ring. Any drug in the 2Cx or DOx series could be synthesized as a 2,6-isomer and would likely retain similar activity, though with potentially diminished potency.