In Kenedy, SH 72 intersects  US 181 and passes through the city's downtown along Main Street; SH 72's only business route is also in this city. To the east of the city, SH 72 intersects  SH 239 and passes through Runge before entering DeWitt County.
SH 72 in Kennedy crosses US 181 and runs through downtown along Main Street; its only business route is within this city. To the east, SH 72 intersects SH 239 and travels through Runge before entering DeWitt County.