She examined the inhibitory signaling molecule TGF-β, which is found near the blood vessels of a tumor. Although the effects of TGF-β and how it restrains normal skin cell growth had been studied by researchers before Fuchs, she specifically looked at the intermediate steps of tumor progression by creating a TGF-β reporter system. She accomplished this by developing tumor cells that expressed a gene commonly found in skin cancer cells, HRasD12V.
She scrutinized the inhibitory signaling molecule TGF-β, which is located near the blood vessels of a tumor. While researchers had previously studied the effects of TGF-β and its control over normal skin cell growth under Fuchs's guidance, she focused on the intermediate stages of tumor progression by creating a TGF-β reporter system. She accomplished this by cultivating cancer cells that expressed HRasD12V.